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Protein

Mitochondrial import inner membrane translocase subunit Tim21

Gene

TIMM21

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Participates in the translocation of transit peptide-containing proteins across the mitochondrial inner membrane. Also required for assembly of mitochondrial respiratory chain complex I and complex IV as component of the MITRAC (mitochondrial translation regulation assembly intermediate of cytochrome c oxidase complex) complex. Probably shuttles between the presequence translocase and respiratory-chain assembly intermediates in a process that promotes incorporation of early nuclear-encoded subunits into these complexes.1 Publication

GO - Biological processi

  • mitochondrial respiratory chain complex I assembly Source: UniProtKB
  • mitochondrial respiratory chain complex IV assembly Source: UniProtKB
  • protein import into mitochondrial matrix Source: UniProtKB
Complete GO annotation...

Keywords - Biological processi

Protein transport, Translocation, Transport

Enzyme and pathway databases

BioCyciZFISH:ENSG00000075336-MONOMER.
ReactomeiR-HSA-1268020. Mitochondrial protein import.

Names & Taxonomyi

Protein namesi
Recommended name:
Mitochondrial import inner membrane translocase subunit Tim21
Alternative name(s):
TIM21-like protein, mitochondrial
Gene namesi
Name:TIMM21
Synonyms:C18orf55, TIM21
ORF Names:HSPC154
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 18

Organism-specific databases

HGNCiHGNC:25010. TIMM21.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei108 – 128HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000075336.
PharmGKBiPA134897360.

Polymorphism and mutation databases

BioMutaiTIMM21.
DMDMi73918912.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 18MitochondrionSequence analysisAdd BLAST18
ChainiPRO_000004322819 – 248Mitochondrial import inner membrane translocase subunit Tim21Add BLAST230

Proteomic databases

EPDiQ9BVV7.
MaxQBiQ9BVV7.
PaxDbiQ9BVV7.
PeptideAtlasiQ9BVV7.
PRIDEiQ9BVV7.
TopDownProteomicsiQ9BVV7.

PTM databases

iPTMnetiQ9BVV7.
PhosphoSitePlusiQ9BVV7.

Expressioni

Gene expression databases

BgeeiENSG00000075336.
CleanExiHS_C18orf55.
ExpressionAtlasiQ9BVV7. baseline and differential.
GenevisibleiQ9BVV7. HS.

Organism-specific databases

HPAiHPA010587.
HPA051543.

Interactioni

Subunit structurei

Component of the TIM23 complex. Component of the MITRAC (mitochondrial translation regulation assembly intermediate of cytochrome c oxidase complex) complex, the core components of this complex being COA3/MITRAC12 and COX14 (Probable) (PubMed:23260140). Interacts with COA3 AND MT-CO1/COX1 (PubMed:26321642).1 Publication2 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
MT-CO1P003953EBI-6570759,EBI-2117234
TIMM23O149253EBI-6570759,EBI-1047996

Protein-protein interaction databases

BioGridi118859. 7 interactors.
IntActiQ9BVV7. 13 interactors.
MINTiMINT-3062491.
STRINGi9606.ENSP00000169551.

Structurei

3D structure databases

ProteinModelPortaliQ9BVV7.
SMRiQ9BVV7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the TIM21 family.Curated

Keywords - Domaini

Transit peptide, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4836. Eukaryota.
ENOG4111NW7. LUCA.
GeneTreeiENSGT00390000011552.
HOGENOMiHOG000007816.
HOVERGENiHBG084542.
InParanoidiQ9BVV7.
KOiK17796.
OMAiCRTHPEV.
OrthoDBiEOG091G0M24.
PhylomeDBiQ9BVV7.
TreeFamiTF315067.

Family and domain databases

InterProiIPR013261. Tim21.
[Graphical view]
PANTHERiPTHR13032. PTHR13032. 1 hit.
PfamiPF08294. TIM21. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9BVV7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MICTFLRAVQ YTEKLHRSSA KRLLLPYIVL NKACLKTEPS LRCGLQYQKK
60 70 80 90 100
TLRPRCILGV TQKTIWTQGP SPRKAKEDGS KQVSVHRSQR GGTAVPTSQK
110 120 130 140 150
VKEAGRDFTY LIVVLFGISI TGGLFYTIFK ELFSSSSPSK IYGRALEKCR
160 170 180 190 200
SHPEVIGVFG ESVKGYGEVT RRGRRQHVRF TEYVKDGLKH TCVKFYIEGS
210 220 230 240
EPGKQGTVYA QVKENPGSGE YDFRYIFVEI ESYPRRTIII EDNRSQDD
Length:248
Mass (Da):28,202
Last modified:June 1, 2001 - v1
Checksum:i7BA2694A9DCD9024
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti34C → Y in AAF29118 (PubMed:11042152).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_05230679G → S.Corresponds to variant rs3737512dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF161503 mRNA. Translation: AAF29118.1.
BC000892 mRNA. Translation: AAH00892.1.
CCDSiCCDS12003.1.
RefSeqiNP_054896.2. NM_014177.2.
UniGeneiHs.532835.

Genome annotation databases

EnsembliENST00000169551; ENSP00000169551; ENSG00000075336.
GeneIDi29090.
KEGGihsa:29090.
UCSCiuc010dqr.2. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF161503 mRNA. Translation: AAF29118.1.
BC000892 mRNA. Translation: AAH00892.1.
CCDSiCCDS12003.1.
RefSeqiNP_054896.2. NM_014177.2.
UniGeneiHs.532835.

3D structure databases

ProteinModelPortaliQ9BVV7.
SMRiQ9BVV7.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi118859. 7 interactors.
IntActiQ9BVV7. 13 interactors.
MINTiMINT-3062491.
STRINGi9606.ENSP00000169551.

PTM databases

iPTMnetiQ9BVV7.
PhosphoSitePlusiQ9BVV7.

Polymorphism and mutation databases

BioMutaiTIMM21.
DMDMi73918912.

Proteomic databases

EPDiQ9BVV7.
MaxQBiQ9BVV7.
PaxDbiQ9BVV7.
PeptideAtlasiQ9BVV7.
PRIDEiQ9BVV7.
TopDownProteomicsiQ9BVV7.

Protocols and materials databases

DNASUi29090.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000169551; ENSP00000169551; ENSG00000075336.
GeneIDi29090.
KEGGihsa:29090.
UCSCiuc010dqr.2. human.

Organism-specific databases

CTDi29090.
GeneCardsiTIMM21.
HGNCiHGNC:25010. TIMM21.
HPAiHPA010587.
HPA051543.
MIMi615180. gene.
neXtProtiNX_Q9BVV7.
OpenTargetsiENSG00000075336.
PharmGKBiPA134897360.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG4836. Eukaryota.
ENOG4111NW7. LUCA.
GeneTreeiENSGT00390000011552.
HOGENOMiHOG000007816.
HOVERGENiHBG084542.
InParanoidiQ9BVV7.
KOiK17796.
OMAiCRTHPEV.
OrthoDBiEOG091G0M24.
PhylomeDBiQ9BVV7.
TreeFamiTF315067.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000075336-MONOMER.
ReactomeiR-HSA-1268020. Mitochondrial protein import.

Miscellaneous databases

ChiTaRSiTIMM21. human.
GenomeRNAii29090.
PROiQ9BVV7.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000075336.
CleanExiHS_C18orf55.
ExpressionAtlasiQ9BVV7. baseline and differential.
GenevisibleiQ9BVV7. HS.

Family and domain databases

InterProiIPR013261. Tim21.
[Graphical view]
PANTHERiPTHR13032. PTHR13032. 1 hit.
PfamiPF08294. TIM21. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTIM21_HUMAN
AccessioniPrimary (citable) accession number: Q9BVV7
Secondary accession number(s): Q9P010
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 30, 2005
Last sequence update: June 1, 2001
Last modified: November 30, 2016
This is version 114 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 18
    Human chromosome 18: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.