Q9BVV6 (TALD3_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Protein TALPID3

Gene names

Name:	KIAA0586
Synonyms:	TALPID3

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	1533 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Required for ciliogenesis and sonic hedgehog/SHH signaling By similarity.
Subcellular location	Cytoplasm › cytoskeleton › centrosome Ref.6 Ref.9.
Sequence similarities	Belongs to the TALPID3 family.
Sequence caution	The sequence BAA25512.2 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.

Ontologies

Keywords
Biological process	Cilium biogenesis/degradation
Cellular component	Cytoplasm Cytoskeleton
Coding sequence diversity	Alternative splicing Polymorphism
Domain	Coiled coil
PTM	Isopeptide bond Ubl conjugation
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	cilium morphogenesis Inferred from sequence or structural similarity. Source: UniProtKB smoothened signaling pathway Inferred from sequence or structural similarity. Source: UniProtKB
Cellular_component	centrosome Inferred from direct assay Ref.9PubMed 21399614. Source: UniProtKB cytoplasm Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Alternative products

This entry describes 4 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q9BVV6-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q9BVV6-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MKGSEVSLEKKKKIKM
     538-613: Missing.

Note: No experimental confirmation available.

Isoform 3 (identifier: Q9BVV6-3)

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MFWCGTCFVTNNMKGSEVSLEKKKKIKM
     122-122: K → NVSLCLTGWSDHSGVITTHCSLYLLRLMRSSHLSLPSSWDYR
     1485-1532: GKAVPLSASQ...EDMESSGADT → LGVHVKKVSC...RQPAQCLCHW

Note: No experimental confirmation available.

Isoform 4 (identifier: Q9BVV6-4)

The sequence of this isoform differs from the canonical sequence as follows:
     1-70: Missing.
     122-122: K → NVSLCLTGWSDHSGVITTHCSLYLLRLMRSSHLSLPSSWDYR

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 1533	1533	Protein TALPID3		PRO_0000050766
Regions
	Region	467 – 554	88	Required for centrosomal localization By similarity
	Coiled coil	182 – 223	42	Potential
	Coiled coil	467 – 501	35	Potential
	Compositional bias	247 – 250	4	Poly-Gln
	Compositional bias	1180 – 1187	8	Poly-Pro
Amino acid modifications
	Cross-link	380		Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) Ref.8
Natural variations
	Alternative sequence	1 – 70	70	Missing in isoform 4.		VSP_046387
	Alternative sequence	1	1	M → MKGSEVSLEKKKKIKM in isoform 2.		VSP_040642
	Alternative sequence	1	1	M → MFWCGTCFVTNNMKGSEVSL EKKKKIKM in isoform 3.		VSP_046005
	Alternative sequence	122	1	K → NVSLCLTGWSDHSGVITTHC SLYLLRLMRSSHLSLPSSWD YR in isoform 3 and isoform 4.		VSP_046006
	Alternative sequence	538 – 613	76	Missing in isoform 2.		VSP_040643
	Alternative sequence	1485 – 1532	48	GKAVP…SGADT → LGVHVKKVSCIGKLGLWRFV IQIISSPRWESSATLRFTDA PCQDVSDAAVSEPRGLLSVS ESQHNAGGHGVFGGRYLLNG KRQPAQCLCHW in isoform 3.		VSP_046007
	Natural variant	828	1	L → P. Ref.1 Ref.2 Ref.3 Ref.5 Ref.7 Corresponds to variant rs1748986 [ dbSNP | Ensembl ].		VAR_069108
Experimental info
	Sequence conflict	1041	1	P → A in BAA25512. Ref.2
	Sequence conflict	1041	1	P → A in BAG64028. Ref.3
	Sequence conflict	1041	1	P → A in EAW80740. Ref.5
	Sequence conflict	1041	1	P → A in AAH66647. Ref.7
Isoform 3:
	Sequence conflict	1568	1	L → P in BAG64028. Ref.3

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified April 5, 2011. Version 4. Checksum: 031F5F28D63FD612	FASTA	1,533	169,307
	10 20 30 40 50 60 MPVKRLREVV SQNHGDHLVL LKDELPCVPP ALSANKRLPV GTGTSLNGTS RGSSDLTSAR 70 80 90 100 110 120 NCYQPLLENP MVSESDFSKD VAVQVLPLDK IEENNKQKAN DIFISQYTMG QKDALRTVLK 130 140 150 160 170 180 QKAQSMPVFK EVKVHLLEDA GIEKDAVTQE TRISPSGIDS ATTVAAATAA AIATAAPLIK 190 200 210 220 230 240 VQSDLEAKVN SVTELLSKLQ ETDKHLQRVT EQQTSIQRKQ EKLHCHDHEK QMNVFMEQHI 250 260 270 280 290 300 RHLEKLQQQQ IDIQTHFISA ALKTSSFQPV SMPSSRAVEK YSVKPEHPNL GSCNPSLYNT 310 320 330 340 350 360 FASKQAPLKE VEDTSFDKQK SPLETPAPRR FAPVPVSRDD ELSKRENLLE EKENMEVSCH 370 380 390 400 410 420 RGNVRLLEQI LNNNDSLTRK SESSNTTSLT RSKIGWTPEK TNRFPSCEEL ETTKVTMQKS 430 440 450 460 470 480 DDVLHDLGQK EKETNSMVQP KESLSMLKLP DLPQNSVKLQ TTNTTRSVLK DAEKILRGVQ 490 500 510 520 530 540 NNKKVLEENL EAIIRAKDGA AMYSLINALS TNREMSEKIR IRKTVDEWIK TISAEIQDEL 550 560 570 580 590 600 SRTDYEQKRF DQKNQRTKKG QNMTKDIRTN TQDKTVNKSV IPRKHSQKQI EEHFRNLPMR 610 620 630 640 650 660 GMPASSLQKE RKEGLLKATT VIQDEDYMLQ VYGKPVYQGH RSTLKKGPYL RFNSPSPKSR 670 680 690 700 710 720 PQRPKVIERV KGTKVKSIRT QTDFYATKPK KMDSKMKHSV PVLPHGDQQY LFSPSREMPT 730 740 750 760 770 780 FSGTLEGHLI PMAILLGQTQ SNSDTMPPAG VIVSKPHPVT VTTSIPPSSR KVETGVKKPN 790 800 810 820 830 840 IAIVEMKSEK KDPPQLTVQV LPSVDIDSIS NSSADVLSPL SSPKEASLPP VQTWIKTPEI 850 860 870 880 890 900 MKVDEEEVKF PGTNFDEIID VIQEEEKCDE IPDSEPILEF NRSVKADSTK YNGPPFPPVA 910 920 930 940 950 960 STFQPTADIL DKVIERKETL ENSLIQWVEQ EIMSRIISGL FPVQQQIAPS ISVSVSETSE 970 980 990 1000 1010 1020 PLTSDIVEGT SSGALQLFVD AGVPVNSNVI KHFVNEALAE TIAVMLGDRE AKKQGPVATG 1030 1040 1050 1060 1070 1080 VSGDASTNET YLPARVCTPL PTPQPTPPCS PSSPAKECVL VKTPDSSPCD SDHDMAFPVK 1090 1100 1110 1120 1130 1140 EICAEKGDDM PAIMLVNTPT VTPTTTPPPA AAVFTPTLSD ISIDKLKVSS PELPKPWGDG 1150 1160 1170 1180 1190 1200 DLPLEEENPN SPQEELHPRA IVMSVAKDEE PESMDFPAQP PPPEPVPFMP FPAGTKAPSP 1210 1220 1230 1240 1250 1260 SQMPGSDSST LESTLSVTVT ETETLDKPIS EGEILFSCGQ KLAPKILEDI GLYLTNLNDS 1270 1280 1290 1300 1310 1320 LSSTLHDAVE MEDDPPSEGQ VIRMSHKKFH ADAILSFAKQ NQESAVSQQA VYHSEDLENS 1330 1340 1350 1360 1370 1380 VGELSEGQRP QLTAAAENIL MGHSLYMQPP VTNTQSLDQQ CDPKPLSRQF DTVSGSIYED 1390 1400 1410 1420 1430 1440 SCASHGPMSL GELELEPNSK LVLPTTLLTA QENDVNLPVA AEDFSQYQLK QNQDVKQVEH 1450 1460 1470 1480 1490 1500 KPSQSYLRVR NKSDIAPSQQ QVSPGDMDRT QIELNPYLTC VFSGGKAVPL SASQMPPAKM 1510 1520 1530 SVMLPSVNLE DCSQSLSLST MQEDMESSGA DTF
	Isoform 2 [UniParc]. Checksum: 63C425B27AC49E13	FASTA	1,472	161,895
	10 20 30 40 50 60 MKGSEVSLEK KKKIKMPVKR LREVVSQNHG DHLVLLKDEL PCVPPALSAN KRLPVGTGTS 70 80 90 100 110 120 LNGTSRGSSD LTSARNCYQP LLENPMVSES DFSKDVAVQV LPLDKIEENN KQKANDIFIS 130 140 150 160 170 180 QYTMGQKDAL RTVLKQKAQS MPVFKEVKVH LLEDAGIEKD AVTQETRISP SGIDSATTVA 190 200 210 220 230 240 AATAAAIATA APLIKVQSDL EAKVNSVTEL LSKLQETDKH LQRVTEQQTS IQRKQEKLHC 250 260 270 280 290 300 HDHEKQMNVF MEQHIRHLEK LQQQQIDIQT HFISAALKTS SFQPVSMPSS RAVEKYSVKP 310 320 330 340 350 360 EHPNLGSCNP SLYNTFASKQ APLKEVEDTS FDKQKSPLET PAPRRFAPVP VSRDDELSKR 370 380 390 400 410 420 ENLLEEKENM EVSCHRGNVR LLEQILNNND SLTRKSESSN TTSLTRSKIG WTPEKTNRFP 430 440 450 460 470 480 SCEELETTKV TMQKSDDVLH DLGQKEKETN SMVQPKESLS MLKLPDLPQN SVKLQTTNTT 490 500 510 520 530 540 RSVLKDAEKI LRGVQNNKKV LEENLEAIIR AKDGAAMYSL INALSTNREM SEKIRIRKTV 550 560 570 580 590 600 DEWIKTISAE IQGLLKATTV IQDEDYMLQV YGKPVYQGHR STLKKGPYLR FNSPSPKSRP 610 620 630 640 650 660 QRPKVIERVK GTKVKSIRTQ TDFYATKPKK MDSKMKHSVP VLPHGDQQYL FSPSREMPTF 670 680 690 700 710 720 SGTLEGHLIP MAILLGQTQS NSDTMPPAGV IVSKPHPVTV TTSIPPSSRK VETGVKKPNI 730 740 750 760 770 780 AIVEMKSEKK DPPQLTVQVL PSVDIDSISN SSADVLSPLS SPKEASLPPV QTWIKTPEIM 790 800 810 820 830 840 KVDEEEVKFP GTNFDEIIDV IQEEEKCDEI PDSEPILEFN RSVKADSTKY NGPPFPPVAS 850 860 870 880 890 900 TFQPTADILD KVIERKETLE NSLIQWVEQE IMSRIISGLF PVQQQIAPSI SVSVSETSEP 910 920 930 940 950 960 LTSDIVEGTS SGALQLFVDA GVPVNSNVIK HFVNEALAET IAVMLGDREA KKQGPVATGV 970 980 990 1000 1010 1020 SGDASTNETY LPARVCTPLP TPQPTPPCSP SSPAKECVLV KTPDSSPCDS DHDMAFPVKE 1030 1040 1050 1060 1070 1080 ICAEKGDDMP AIMLVNTPTV TPTTTPPPAA AVFTPTLSDI SIDKLKVSSP ELPKPWGDGD 1090 1100 1110 1120 1130 1140 LPLEEENPNS PQEELHPRAI VMSVAKDEEP ESMDFPAQPP PPEPVPFMPF PAGTKAPSPS 1150 1160 1170 1180 1190 1200 QMPGSDSSTL ESTLSVTVTE TETLDKPISE GEILFSCGQK LAPKILEDIG LYLTNLNDSL 1210 1220 1230 1240 1250 1260 SSTLHDAVEM EDDPPSEGQV IRMSHKKFHA DAILSFAKQN QESAVSQQAV YHSEDLENSV 1270 1280 1290 1300 1310 1320 GELSEGQRPQ LTAAAENILM GHSLYMQPPV TNTQSLDQQC DPKPLSRQFD TVSGSIYEDS 1330 1340 1350 1360 1370 1380 CASHGPMSLG ELELEPNSKL VLPTTLLTAQ ENDVNLPVAA EDFSQYQLKQ NQDVKQVEHK 1390 1400 1410 1420 1430 1440 PSQSYLRVRN KSDIAPSQQQ VSPGDMDRTQ IELNPYLTCV FSGGKAVPLS ASQMPPAKMS 1450 1460 1470 VMLPSVNLED CSQSLSLSTM QEDMESSGAD TF
	Isoform 3 [UniParc]. Checksum: A1E4498F393D0822	FASTA	1,644	182,002
	10 20 30 40 50 60 MFWCGTCFVT NNMKGSEVSL EKKKKIKMPV KRLREVVSQN HGDHLVLLKD ELPCVPPALS 70 80 90 100 110 120 ANKRLPVGTG TSLNGTSRGS SDLTSARNCY QPLLENPMVS ESDFSKDVAV QVLPLDKIEE 130 140 150 160 170 180 NNKQKANDIF ISQYTMGQKD ALRTVLKQNV SLCLTGWSDH SGVITTHCSL YLLRLMRSSH 190 200 210 220 230 240 LSLPSSWDYR AQSMPVFKEV KVHLLEDAGI EKDAVTQETR ISPSGIDSAT TVAAATAAAI 250 260 270 280 290 300 ATAAPLIKVQ SDLEAKVNSV TELLSKLQET DKHLQRVTEQ QTSIQRKQEK LHCHDHEKQM 310 320 330 340 350 360 NVFMEQHIRH LEKLQQQQID IQTHFISAAL KTSSFQPVSM PSSRAVEKYS VKPEHPNLGS 370 380 390 400 410 420 CNPSLYNTFA SKQAPLKEVE DTSFDKQKSP LETPAPRRFA PVPVSRDDEL SKRENLLEEK 430 440 450 460 470 480 ENMEVSCHRG NVRLLEQILN NNDSLTRKSE SSNTTSLTRS KIGWTPEKTN RFPSCEELET 490 500 510 520 530 540 TKVTMQKSDD VLHDLGQKEK ETNSMVQPKE SLSMLKLPDL PQNSVKLQTT NTTRSVLKDA 550 560 570 580 590 600 EKILRGVQNN KKVLEENLEA IIRAKDGAAM YSLINALSTN REMSEKIRIR KTVDEWIKTI 610 620 630 640 650 660 SAEIQDELSR TDYEQKRFDQ KNQRTKKGQN MTKDIRTNTQ DKTVNKSVIP RKHSQKQIEE 670 680 690 700 710 720 HFRNLPMRGM PASSLQKERK EGLLKATTVI QDEDYMLQVY GKPVYQGHRS TLKKGPYLRF 730 740 750 760 770 780 NSPSPKSRPQ RPKVIERVKG TKVKSIRTQT DFYATKPKKM DSKMKHSVPV LPHGDQQYLF 790 800 810 820 830 840 SPSREMPTFS GTLEGHLIPM AILLGQTQSN SDTMPPAGVI VSKPHPVTVT TSIPPSSRKV 850 860 870 880 890 900 ETGVKKPNIA IVEMKSEKKD PPQLTVQVLP SVDIDSISNS SADVLSPLSS PKEASLPPVQ 910 920 930 940 950 960 TWIKTPEIMK VDEEEVKFPG TNFDEIIDVI QEEEKCDEIP DSEPILEFNR SVKADSTKYN 970 980 990 1000 1010 1020 GPPFPPVAST FQPTADILDK VIERKETLEN SLIQWVEQEI MSRIISGLFP VQQQIAPSIS 1030 1040 1050 1060 1070 1080 VSVSETSEPL TSDIVEGTSS GALQLFVDAG VPVNSNVIKH FVNEALAETI AVMLGDREAK 1090 1100 1110 1120 1130 1140 KQGPVATGVS GDASTNETYL PARVCTPLPT PQPTPPCSPS SPAKECVLVK TPDSSPCDSD 1150 1160 1170 1180 1190 1200 HDMAFPVKEI CAEKGDDMPA IMLVNTPTVT PTTTPPPAAA VFTPTLSDIS IDKLKVSSPE 1210 1220 1230 1240 1250 1260 LPKPWGDGDL PLEEENPNSP QEELHPRAIV MSVAKDEEPE SMDFPAQPPP PEPVPFMPFP 1270 1280 1290 1300 1310 1320 AGTKAPSPSQ MPGSDSSTLE STLSVTVTET ETLDKPISEG EILFSCGQKL APKILEDIGL 1330 1340 1350 1360 1370 1380 YLTNLNDSLS STLHDAVEME DDPPSEGQVI RMSHKKFHAD AILSFAKQNQ ESAVSQQAVY 1390 1400 1410 1420 1430 1440 HSEDLENSVG ELSEGQRPQL TAAAENILMG HSLYMQPPVT NTQSLDQQCD PKPLSRQFDT 1450 1460 1470 1480 1490 1500 VSGSIYEDSC ASHGPMSLGE LELEPNSKLV LPTTLLTAQE NDVNLPVAAE DFSQYQLKQN 1510 1520 1530 1540 1550 1560 QDVKQVEHKP SQSYLRVRNK SDIAPSQQQV SPGDMDRTQI ELNPYLTCVF SGLGVHVKKV 1570 1580 1590 1600 1610 1620 SCIGKLGLWR FVIQIISSPR WESSATLRFT DAPCQDVSDA AVSEPRGLLS VSESQHNAGG 1630 1640 HGVFGGRYLL NGKRQPAQCL CHWF
	Isoform 4 [UniParc]. Checksum: 1AD93094E18A3F5D	FASTA	1,504	166,422
	10 20 30 40 50 60 MVSESDFSKD VAVQVLPLDK IEENNKQKAN DIFISQYTMG QKDALRTVLK QNVSLCLTGW 70 80 90 100 110 120 SDHSGVITTH CSLYLLRLMR SSHLSLPSSW DYRAQSMPVF KEVKVHLLED AGIEKDAVTQ 130 140 150 160 170 180 ETRISPSGID SATTVAAATA AAIATAAPLI KVQSDLEAKV NSVTELLSKL QETDKHLQRV 190 200 210 220 230 240 TEQQTSIQRK QEKLHCHDHE KQMNVFMEQH IRHLEKLQQQ QIDIQTHFIS AALKTSSFQP 250 260 270 280 290 300 VSMPSSRAVE KYSVKPEHPN LGSCNPSLYN TFASKQAPLK EVEDTSFDKQ KSPLETPAPR 310 320 330 340 350 360 RFAPVPVSRD DELSKRENLL EEKENMEVSC HRGNVRLLEQ ILNNNDSLTR KSESSNTTSL 370 380 390 400 410 420 TRSKIGWTPE KTNRFPSCEE LETTKVTMQK SDDVLHDLGQ KEKETNSMVQ PKESLSMLKL 430 440 450 460 470 480 PDLPQNSVKL QTTNTTRSVL KDAEKILRGV QNNKKVLEEN LEAIIRAKDG AAMYSLINAL 490 500 510 520 530 540 STNREMSEKI RIRKTVDEWI KTISAEIQDE LSRTDYEQKR FDQKNQRTKK GQNMTKDIRT 550 560 570 580 590 600 NTQDKTVNKS VIPRKHSQKQ IEEHFRNLPM RGMPASSLQK ERKEGLLKAT TVIQDEDYML 610 620 630 640 650 660 QVYGKPVYQG HRSTLKKGPY LRFNSPSPKS RPQRPKVIER VKGTKVKSIR TQTDFYATKP 670 680 690 700 710 720 KKMDSKMKHS VPVLPHGDQQ YLFSPSREMP TFSGTLEGHL IPMAILLGQT QSNSDTMPPA 730 740 750 760 770 780 GVIVSKPHPV TVTTSIPPSS RKVETGVKKP NIAIVEMKSE KKDPPQLTVQ VLPSVDIDSI 790 800 810 820 830 840 SNSSADVLSP LSSPKEASLP PVQTWIKTPE IMKVDEEEVK FPGTNFDEII DVIQEEEKCD 850 860 870 880 890 900 EIPDSEPILE FNRSVKADST KYNGPPFPPV ASTFQPTADI LDKVIERKET LENSLIQWVE 910 920 930 940 950 960 QEIMSRIISG LFPVQQQIAP SISVSVSETS EPLTSDIVEG TSSGALQLFV DAGVPVNSNV 970 980 990 1000 1010 1020 IKHFVNEALA ETIAVMLGDR EAKKQGPVAT GVSGDASTNE TYLPARVCTP LPTPQPTPPC 1030 1040 1050 1060 1070 1080 SPSSPAKECV LVKTPDSSPC DSDHDMAFPV KEICAEKGDD MPAIMLVNTP TVTPTTTPPP 1090 1100 1110 1120 1130 1140 AAAVFTPTLS DISIDKLKVS SPELPKPWGD GDLPLEEENP NSPQEELHPR AIVMSVAKDE 1150 1160 1170 1180 1190 1200 EPESMDFPAQ PPPPEPVPFM PFPAGTKAPS PSQMPGSDSS TLESTLSVTV TETETLDKPI 1210 1220 1230 1240 1250 1260 SEGEILFSCG QKLAPKILED IGLYLTNLND SLSSTLHDAV EMEDDPPSEG QVIRMSHKKF 1270 1280 1290 1300 1310 1320 HADAILSFAK QNQESAVSQQ AVYHSEDLEN SVGELSEGQR PQLTAAAENI LMGHSLYMQP 1330 1340 1350 1360 1370 1380 PVTNTQSLDQ QCDPKPLSRQ FDTVSGSIYE DSCASHGPMS LGELELEPNS KLVLPTTLLT 1390 1400 1410 1420 1430 1440 AQENDVNLPV AAEDFSQYQL KQNQDVKQVE HKPSQSYLRV RNKSDIAPSQ QQVSPGDMDR 1450 1460 1470 1480 1490 1500 TQIELNPYLT CVFSGGKAVP LSASQMPPAK MSVMLPSVNL EDCSQSLSLS TMQEDMESSG ADTF

References

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[1]	"Cloning an isoform of KIAA0586 gene related to spermatogenesis." Zhen Y., Huo R., Lu L., Xu M., Yin L.L., Xu Z.Y., Li J.M., Zhou Z.M., Sha J.H. Submitted (AUG-2003) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 4), VARIANT PRO-828.
[2]	"Prediction of the coding sequences of unidentified human genes. IX. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro." Nagase T., Ishikawa K., Miyajima N., Tanaka A., Kotani H., Nomura N., Ohara O. DNA Res. 5:31-39(1998) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT PRO-828. Tissue: Brain.
[3]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3), VARIANT PRO-828. Tissue: Testis.
[4]	"The DNA sequence and analysis of human chromosome 14." Heilig R., Eckenberg R., Petit J.-L., Fonknechten N., Da Silva C., Cattolico L., Levy M., Barbe V., De Berardinis V., Ureta-Vidal A., Pelletier E., Vico V., Anthouard V., Rowen L., Madan A., Qin S., Sun H., Du H. , Pepin K., Artiguenave F., Robert C., Cruaud C., Bruels T., Jaillon O., Friedlander L., Samson G., Brottier P., Cure S., Segurens B., Aniere F., Samain S., Crespeau H., Abbasi N., Aiach N., Boscus D., Dickhoff R., Dors M., Dubois I., Friedman C., Gouyvenoux M., James R., Madan A., Mairey-Estrada B., Mangenot S., Martins N., Menard M., Oztas S., Ratcliffe A., Shaffer T., Trask B., Vacherie B., Bellemere C., Belser C., Besnard-Gonnet M., Bartol-Mavel D., Boutard M., Briez-Silla S., Combette S., Dufosse-Laurent V., Ferron C., Lechaplais C., Louesse C., Muselet D., Magdelenat G., Pateau E., Petit E., Sirvain-Trukniewicz P., Trybou A., Vega-Czarny N., Bataille E., Bluet E., Bordelais I., Dubois M., Dumont C., Guerin T., Haffray S., Hammadi R., Muanga J., Pellouin V., Robert D., Wunderle E., Gauguet G., Roy A., Sainte-Marthe L., Verdier J., Verdier-Discala C., Hillier L.W., Fulton L., McPherson J., Matsuda F., Wilson R., Scarpelli C., Gyapay G., Wincker P., Saurin W., Quetier F., Waterston R., Hood L., Weissenbach J. Nature 421:601-607(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANT PRO-828.
[6]	"Proteomic characterization of the human centrosome by protein correlation profiling." Andersen J.S., Wilkinson C.J., Mayor T., Mortensen P., Nigg E.A., Mann M. Nature 426:570-574(2003) [PubMed] [Europe PMC] [Abstract] Cited for: MASS SPECTROMETRY, SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS]. Tissue: Lymphoblast.
[7]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2), VARIANT PRO-828. Tissue: Placenta and Skin.
[8]	"Tryptic digestion of ubiquitin standards reveals an improved strategy for identifying ubiquitinated proteins by mass spectrometry." Denis N.J., Vasilescu J., Lambert J.-P., Smith J.C., Figeys D. Proteomics 7:868-874(2007) [PubMed] [Europe PMC] [Abstract] Cited for: UBIQUITINATION [LARGE SCALE ANALYSIS] AT LYS-380, MASS SPECTROMETRY. Tissue: Mammary cancer.
[9]	"The Talpid3 gene (KIAA0586) encodes a centrosomal protein that is essential for primary cilia formation." Yin Y., Bangs F., Paton I.R., Prescott A., James J., Davey M.G., Whitley P., Genikhovich G., Technau U., Burt D.W., Tickle C. Development 136:655-664(2009) [PubMed] [Europe PMC] [Abstract] Cited for: SUBCELLULAR LOCATION.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AY359881 mRNA. Translation: AAQ63404.1. AB011158 mRNA. Translation: BAA25512.2. Different initiation. AK302836 mRNA. Translation: BAG64028.1. AL135752 Genomic DNA. No translation available. AL139021 Genomic DNA. No translation available. CH471061 Genomic DNA. Translation: EAW80740.1. BC000900 mRNA. Translation: AAH00900.1. BC066647 mRNA. Translation: AAH66647.2.
IPI	IPI00006096. IPI00413612. IPI00941339. IPI01025575.
PIR	T00344.
RefSeq	NP_001231118.1. NM_001244189.1. NP_001231119.1. NM_001244190.1. NP_001231120.1. NM_001244191.1. NP_001231121.1. NM_001244192.1.
UniGene	Hs.232532.
3D structure databases
ProteinModelPortal	Q9BVV6.
ModBase	Search...
Protein-protein interaction databases
STRING	9606.ENSP00000261244.
PTM databases
PhosphoSite	Q9BVV6.
Polymorphism databases
DMDM	20140756.
Proteomic databases
PaxDb	Q9BVV6.
PRIDE	Q9BVV6.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000261244; ENSP00000261244; ENSG00000100578. ENST00000354386; ENSP00000346359; ENSG00000100578. ENST00000423743; ENSP00000399427; ENSG00000100578. ENST00000556134; ENSP00000452351; ENSG00000100578.
GeneID	9786.
KEGG	hsa:9786.
UCSC	uc001xdu.4. human.
Organism-specific databases
CTD	9786.
GeneCards	GC14P058894.
HGNC	HGNC:19960. KIAA0586.
HPA	HPA000846.
MIM	610178. gene.
neXtProt	NX_Q9BVV6.
HUGE	Search...
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG40443.
HOGENOM	HOG000168599.
HOVERGEN	HBG052187.
InParanoid	Q9BVV6.
PhylomeDB	Q9BVV6.
Gene expression databases
ArrayExpress	Q9BVV6.
Bgee	Q9BVV6.
CleanEx	HS_KIAA0586.
Genevestigator	Q9BVV6.
Family and domain databases
ProtoNet	Search...
Other
GenomeRNAi	9786.
NextBio	36850.
SOURCE	Search...

Entry information

Entry name

TALD3_HUMAN

Accession

Primary (citable) accession number: Q9BVV6
Secondary accession number(s): B4DZB6 , E7EWM8, J3KQH9, O60328, Q6NYC6, Q6UV20

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 23, 2002
Last sequence update:	April 5, 2011
Last modified:	May 1, 2013
This is version 81 of the entry and version 4 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.