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Q9BVT8

- TMUB1_HUMAN

UniProt

Q9BVT8 - TMUB1_HUMAN

Protein

Transmembrane and ubiquitin-like domain-containing protein 1

Gene

TMUB1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 106 (01 Oct 2014)
      Sequence version 1 (01 Jun 2001)
      Previous versions | rss
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    Functioni

    May contribute to the regulation of translation during cell-cycle progression. May contribute to the regulation of cell proliferation By similarity.By similarity

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Transmembrane and ubiquitin-like domain-containing protein 1
    Alternative name(s):
    Dendritic cell-derived ubiquitin-like protein
    Short name:
    DULP
    Hepatocyte odd protein shuttling protein
    Ubiquitin-like protein SB144
    Gene namesi
    Name:TMUB1
    Synonyms:C7orf21, DULP, HOPS
    ORF Names:SB144, UNQ763/PRO1555
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 7

    Organism-specific databases

    HGNCiHGNC:21709. TMUB1.

    Subcellular locationi

    Membrane Curated; Multi-pass membrane protein Curated. Cytoplasm 1 Publication. Nucleus 1 Publication
    Note: Predominantly nuclear during growth arrest By similarity. Actively exported from the nucleus in dividing cells.By similarity

    GO - Cellular componenti

    1. cytoplasm Source: HPA
    2. integral component of membrane Source: UniProtKB-KW
    3. nucleus Source: HPA

    Keywords - Cellular componenti

    Cytoplasm, Membrane, Nucleus

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA134863959.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 246246Transmembrane and ubiquitin-like domain-containing protein 1PRO_0000114922Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei71 – 711Phosphothreonine1 Publication
    Modified residuei92 – 921Phosphothreonine2 Publications
    Modified residuei98 – 981Phosphoserine3 Publications

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    MaxQBiQ9BVT8.
    PaxDbiQ9BVT8.
    PeptideAtlasiQ9BVT8.
    PRIDEiQ9BVT8.

    PTM databases

    PhosphoSiteiQ9BVT8.

    Miscellaneous databases

    PMAP-CutDBQ9BVT8.

    Expressioni

    Gene expression databases

    ArrayExpressiQ9BVT8.
    BgeeiQ9BVT8.
    CleanExiHS_TMUB1.
    GenevestigatoriQ9BVT8.

    Organism-specific databases

    HPAiHPA029429.

    Interactioni

    Subunit structurei

    Interacts with EEF1A1.By similarity

    Protein-protein interaction databases

    BioGridi123686. 9 interactions.
    STRINGi9606.ENSP00000297533.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9BVT8.
    SMRiQ9BVT8. Positions 105-186.
    ModBaseiSearch...
    MobiDBiSearch...

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei195 – 21521HelicalSequence AnalysisAdd
    BLAST
    Transmembranei221 – 24121HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini103 – 17674Ubiquitin-likePROSITE-ProRule annotationAdd
    BLAST

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi18 – 2710Nuclear export signalSequence Analysis

    Sequence similaritiesi

    Contains 1 ubiquitin-like domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG69268.
    HOGENOMiHOG000232067.
    HOVERGENiHBG050920.
    InParanoidiQ9BVT8.
    OMAiCVLHCHI.
    OrthoDBiEOG7TF7B5.
    PhylomeDBiQ9BVT8.
    TreeFamiTF329265.

    Family and domain databases

    InterProiIPR000626. Ubiquitin-like.
    IPR029071. Ubiquitin-rel_dom.
    [Graphical view]
    PfamiPF00240. ubiquitin. 1 hit.
    [Graphical view]
    SMARTiSM00213. UBQ. 1 hit.
    [Graphical view]
    SUPFAMiSSF54236. SSF54236. 1 hit.
    PROSITEiPS50053. UBIQUITIN_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9BVT8-1 [UniParc]FASTAAdd to Basket

    « Hide

    MTLIEGVGDE VTVLFSVLAC LLVLALAWVS THTAEGGDPL PQPSGTPTPS    50
    QPSAAMAATD SMRGEAPGAE TPSLRHRGQA AQPEPSTGFT ATPPAPDSPQ 100
    EPLVLRLKFL NDSEQVARAW PHDTIGSLKR TQFPGREQQV RLIYQGQLLG 150
    DDTQTLGSLH LPPNCVLHCH VSTRVGPPNP PCPPGSEPGP SGLEIGSLLL 200
    PLLLLLLLLL WYCQIQYRPF FPLTATLGLA GFTLLLSLLA FAMYRP 246
    Length:246
    Mass (Da):26,261
    Last modified:June 1, 2001 - v1
    Checksum:iE08E25A6B37665B3
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY603380 mRNA. Translation: AAU00156.1.
    AY037155 mRNA. Translation: AAK67645.1.
    AY358481 mRNA. Translation: AAQ88845.1.
    AK314035 mRNA. Translation: BAG36745.1.
    AC010973 Genomic DNA. No translation available.
    CH471173 Genomic DNA. Translation: EAW54030.1.
    CH471173 Genomic DNA. Translation: EAW54032.1.
    BC000936 mRNA. Translation: AAH00936.1.
    BC033182 mRNA. Translation: AAH33182.1.
    CCDSiCCDS5920.1.
    RefSeqiNP_001129516.1. NM_001136044.1.
    NP_113622.1. NM_031434.3.
    UniGeneiHs.726215.

    Genome annotation databases

    EnsembliENST00000297533; ENSP00000297533; ENSG00000164897.
    ENST00000392818; ENSP00000376565; ENSG00000164897.
    ENST00000462940; ENSP00000417519; ENSG00000164897.
    ENST00000476627; ENSP00000419214; ENSG00000164897.
    ENST00000482202; ENSP00000418709; ENSG00000164897.
    GeneIDi83590.
    KEGGihsa:83590.
    UCSCiuc003wjb.3. human.

    Polymorphism databases

    DMDMi34922062.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY603380 mRNA. Translation: AAU00156.1 .
    AY037155 mRNA. Translation: AAK67645.1 .
    AY358481 mRNA. Translation: AAQ88845.1 .
    AK314035 mRNA. Translation: BAG36745.1 .
    AC010973 Genomic DNA. No translation available.
    CH471173 Genomic DNA. Translation: EAW54030.1 .
    CH471173 Genomic DNA. Translation: EAW54032.1 .
    BC000936 mRNA. Translation: AAH00936.1 .
    BC033182 mRNA. Translation: AAH33182.1 .
    CCDSi CCDS5920.1.
    RefSeqi NP_001129516.1. NM_001136044.1.
    NP_113622.1. NM_031434.3.
    UniGenei Hs.726215.

    3D structure databases

    ProteinModelPortali Q9BVT8.
    SMRi Q9BVT8. Positions 105-186.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 123686. 9 interactions.
    STRINGi 9606.ENSP00000297533.

    PTM databases

    PhosphoSitei Q9BVT8.

    Polymorphism databases

    DMDMi 34922062.

    Proteomic databases

    MaxQBi Q9BVT8.
    PaxDbi Q9BVT8.
    PeptideAtlasi Q9BVT8.
    PRIDEi Q9BVT8.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000297533 ; ENSP00000297533 ; ENSG00000164897 .
    ENST00000392818 ; ENSP00000376565 ; ENSG00000164897 .
    ENST00000462940 ; ENSP00000417519 ; ENSG00000164897 .
    ENST00000476627 ; ENSP00000419214 ; ENSG00000164897 .
    ENST00000482202 ; ENSP00000418709 ; ENSG00000164897 .
    GeneIDi 83590.
    KEGGi hsa:83590.
    UCSCi uc003wjb.3. human.

    Organism-specific databases

    CTDi 83590.
    GeneCardsi GC07M150778.
    HGNCi HGNC:21709. TMUB1.
    HPAi HPA029429.
    MIMi 614792. gene.
    neXtProti NX_Q9BVT8.
    PharmGKBi PA134863959.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG69268.
    HOGENOMi HOG000232067.
    HOVERGENi HBG050920.
    InParanoidi Q9BVT8.
    OMAi CVLHCHI.
    OrthoDBi EOG7TF7B5.
    PhylomeDBi Q9BVT8.
    TreeFami TF329265.

    Miscellaneous databases

    ChiTaRSi TMUB1. human.
    GenomeRNAii 83590.
    NextBioi 72505.
    PMAP-CutDB Q9BVT8.
    PROi Q9BVT8.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q9BVT8.
    Bgeei Q9BVT8.
    CleanExi HS_TMUB1.
    Genevestigatori Q9BVT8.

    Family and domain databases

    InterProi IPR000626. Ubiquitin-like.
    IPR029071. Ubiquitin-rel_dom.
    [Graphical view ]
    Pfami PF00240. ubiquitin. 1 hit.
    [Graphical view ]
    SMARTi SM00213. UBQ. 1 hit.
    [Graphical view ]
    SUPFAMi SSF54236. SSF54236. 1 hit.
    PROSITEi PS50053. UBIQUITIN_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "HOPS: a novel cAMP-dependent shuttling protein involved in protein synthesis regulation."
      Della Fazia M.A., Castelli M., Bartoli D., Pieroni S., Pettirossi V., Piobbico D., Viola-Magni M., Servillo G.
      J. Cell Sci. 118:3185-3194(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "Cloning and characterization of DULP, a novel ubiquitin-like molecule from human dendritic cells."
      Liu G.Y., Liu S.X., Li P., Tang L., Han Y.M., An H.Z., Li J.Y., Dai X.K., Li N., Cao X.T., Yu Y.Z.
      Cell. Mol. Immunol. 6:27-33(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], SUBCELLULAR LOCATION.
      Tissue: Dendritic cell.
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    4. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    5. "The DNA sequence of human chromosome 7."
      Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H., Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K., Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A., Delehaunty K.D., Miner T.L.
      , Nash W.E., Cordes M., Du H., Sun H., Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A., Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P., Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M., Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S., Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R., Strowmatt C., Latreille P., Miller N., Johnson D., Murray J., Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W., Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A., Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E., Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E., Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A., Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A., Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R., McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H., Wilson R.K.
      Nature 424:157-164(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Kidney and Placenta.
    8. "Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."
      Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R., Greff Z., Keri G., Stemmann O., Mann M.
      Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-98, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    9. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-71; THR-92 AND SER-98, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    10. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
      Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
      Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-92 AND SER-98, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.

    Entry informationi

    Entry nameiTMUB1_HUMAN
    AccessioniPrimary (citable) accession number: Q9BVT8
    Secondary accession number(s): D3DX06, Q53AQ2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 19, 2003
    Last sequence update: June 1, 2001
    Last modified: October 1, 2014
    This is version 106 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 7
      Human chromosome 7: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3