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Q9BVT8 (TMUB1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 102. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Transmembrane and ubiquitin-like domain-containing protein 1
Alternative name(s):
Dendritic cell-derived ubiquitin-like protein
Short name=DULP
Hepatocyte odd protein shuttling protein
Ubiquitin-like protein SB144
Gene names
Name:TMUB1
Synonyms:C7orf21, DULP, HOPS
ORF Names:SB144, UNQ763/PRO1555
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length246 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

May contribute to the regulation of translation during cell-cycle progression. May contribute to the regulation of cell proliferation By similarity.

Subunit structure

Interacts with EEF1A1 By similarity.

Subcellular location

Membrane; Multi-pass membrane protein Potential. Cytoplasm. Nucleus. Note: Predominantly nuclear during growth arrest By similarity. Actively exported from the nucleus in dividing cells. Ref.2

Sequence similarities

Contains 1 ubiquitin-like domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 246246Transmembrane and ubiquitin-like domain-containing protein 1
PRO_0000114922

Regions

Transmembrane195 – 21521Helical; Potential
Transmembrane221 – 24121Helical; Potential
Domain103 – 17674Ubiquitin-like
Motif18 – 2710Nuclear export signal Potential

Amino acid modifications

Modified residue711Phosphothreonine Ref.9
Modified residue921Phosphothreonine Ref.9 Ref.10
Modified residue981Phosphoserine Ref.8 Ref.9 Ref.10

Sequences

Sequence LengthMass (Da)Tools
Q9BVT8 [UniParc].

Last modified June 1, 2001. Version 1.
Checksum: E08E25A6B37665B3

FASTA24626,261
        10         20         30         40         50         60 
MTLIEGVGDE VTVLFSVLAC LLVLALAWVS THTAEGGDPL PQPSGTPTPS QPSAAMAATD 

        70         80         90        100        110        120 
SMRGEAPGAE TPSLRHRGQA AQPEPSTGFT ATPPAPDSPQ EPLVLRLKFL NDSEQVARAW 

       130        140        150        160        170        180 
PHDTIGSLKR TQFPGREQQV RLIYQGQLLG DDTQTLGSLH LPPNCVLHCH VSTRVGPPNP 

       190        200        210        220        230        240 
PCPPGSEPGP SGLEIGSLLL PLLLLLLLLL WYCQIQYRPF FPLTATLGLA GFTLLLSLLA 


FAMYRP 

« Hide

References

« Hide 'large scale' references
[1]"HOPS: a novel cAMP-dependent shuttling protein involved in protein synthesis regulation."
Della Fazia M.A., Castelli M., Bartoli D., Pieroni S., Pettirossi V., Piobbico D., Viola-Magni M., Servillo G.
J. Cell Sci. 118:3185-3194(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]"Cloning and characterization of DULP, a novel ubiquitin-like molecule from human dendritic cells."
Liu G.Y., Liu S.X., Li P., Tang L., Han Y.M., An H.Z., Li J.Y., Dai X.K., Li N., Cao X.T., Yu Y.Z.
Cell. Mol. Immunol. 6:27-33(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], SUBCELLULAR LOCATION.
Tissue: Dendritic cell.
[3]"The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment."
Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J., Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P., Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E. expand/collapse author list , Heldens S., Huang A., Kim H.S., Klimowski L., Jin Y., Johnson S., Lee J., Lewis L., Liao D., Mark M.R., Robbie E., Sanchez C., Schoenfeld J., Seshagiri S., Simmons L., Singh J., Smith V., Stinson J., Vagts A., Vandlen R.L., Watanabe C., Wieand D., Woods K., Xie M.-H., Yansura D.G., Yi S., Yu G., Yuan J., Zhang M., Zhang Z., Goddard A.D., Wood W.I., Godowski P.J., Gray A.M.
Genome Res. 13:2265-2270(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[4]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[5]"The DNA sequence of human chromosome 7."
Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H., Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K., Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A., Delehaunty K.D., Miner T.L. expand/collapse author list , Nash W.E., Cordes M., Du H., Sun H., Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A., Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P., Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M., Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S., Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R., Strowmatt C., Latreille P., Miller N., Johnson D., Murray J., Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W., Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A., Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E., Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E., Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A., Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A., Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R., McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H., Wilson R.K.
Nature 424:157-164(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[6]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[7]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Kidney and Placenta.
[8]"Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."
Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R., Greff Z., Keri G., Stemmann O., Mann M.
Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-98, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Cervix carcinoma.
[9]"A quantitative atlas of mitotic phosphorylation."
Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P.
Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-71; THR-92 AND SER-98, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Cervix carcinoma.
[10]"Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-92 AND SER-98, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Cervix carcinoma.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AY603380 mRNA. Translation: AAU00156.1.
AY037155 mRNA. Translation: AAK67645.1.
AY358481 mRNA. Translation: AAQ88845.1.
AK314035 mRNA. Translation: BAG36745.1.
AC010973 Genomic DNA. No translation available.
CH471173 Genomic DNA. Translation: EAW54030.1.
CH471173 Genomic DNA. Translation: EAW54032.1.
BC000936 mRNA. Translation: AAH00936.1.
BC033182 mRNA. Translation: AAH33182.1.
RefSeqNP_001129516.1. NM_001136044.1.
NP_113622.1. NM_031434.3.
UniGeneHs.726215.

3D structure databases

ProteinModelPortalQ9BVT8.
SMRQ9BVT8. Positions 105-186.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid123686. 8 interactions.
STRING9606.ENSP00000297533.

PTM databases

PhosphoSiteQ9BVT8.

Polymorphism databases

DMDM34922062.

Proteomic databases

PaxDbQ9BVT8.
PeptideAtlasQ9BVT8.
PRIDEQ9BVT8.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000297533; ENSP00000297533; ENSG00000164897.
ENST00000392818; ENSP00000376565; ENSG00000164897.
ENST00000462940; ENSP00000417519; ENSG00000164897.
ENST00000476627; ENSP00000419214; ENSG00000164897.
ENST00000482202; ENSP00000418709; ENSG00000164897.
GeneID83590.
KEGGhsa:83590.
UCSCuc003wjb.3. human.

Organism-specific databases

CTD83590.
GeneCardsGC07M150778.
HGNCHGNC:21709. TMUB1.
HPAHPA029429.
MIM614792. gene.
neXtProtNX_Q9BVT8.
PharmGKBPA134863959.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG69268.
HOGENOMHOG000232067.
HOVERGENHBG050920.
InParanoidQ9BVT8.
OMACVLHCHI.
OrthoDBEOG7TF7B5.
PhylomeDBQ9BVT8.
TreeFamTF329265.

Gene expression databases

ArrayExpressQ9BVT8.
BgeeQ9BVT8.
CleanExHS_TMUB1.
GenevestigatorQ9BVT8.

Family and domain databases

InterProIPR000626. Ubiquitin-like.
[Graphical view]
PfamPF00240. ubiquitin. 1 hit.
[Graphical view]
SMARTSM00213. UBQ. 1 hit.
[Graphical view]
PROSITEPS50053. UBIQUITIN_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSTMUB1. human.
GenomeRNAi83590.
NextBio72505.
PMAP-CutDBQ9BVT8.
PROQ9BVT8.
SOURCESearch...

Entry information

Entry nameTMUB1_HUMAN
AccessionPrimary (citable) accession number: Q9BVT8
Secondary accession number(s): D3DX06, Q53AQ2
Entry history
Integrated into UniProtKB/Swiss-Prot: September 19, 2003
Last sequence update: June 1, 2001
Last modified: April 16, 2014
This is version 102 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human chromosome 7

Human chromosome 7: entries, gene names and cross-references to MIM