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Q9BVT8

- TMUB1_HUMAN

UniProt

Q9BVT8 - TMUB1_HUMAN

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Protein

Transmembrane and ubiquitin-like domain-containing protein 1

Gene

TMUB1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli

Functioni

May contribute to the regulation of translation during cell-cycle progression. May contribute to the regulation of cell proliferation (By similarity).By similarity

Names & Taxonomyi

Protein namesi
Recommended name:
Transmembrane and ubiquitin-like domain-containing protein 1
Alternative name(s):
Dendritic cell-derived ubiquitin-like protein
Short name:
DULP
Hepatocyte odd protein shuttling protein
Ubiquitin-like protein SB144
Gene namesi
Name:TMUB1
Synonyms:C7orf21, DULP, HOPS
ORF Names:SB144, UNQ763/PRO1555
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 7

Organism-specific databases

HGNCiHGNC:21709. TMUB1.

Subcellular locationi

Membrane Curated; Multi-pass membrane protein Curated. Cytoplasm 1 Publication. Nucleus 1 Publication
Note: Predominantly nuclear during growth arrest (By similarity). Actively exported from the nucleus in dividing cells.By similarity

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei195 – 21521HelicalSequence AnalysisAdd
BLAST
Transmembranei221 – 24121HelicalSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. cytoplasm Source: HPA
  2. integral component of membrane Source: UniProtKB-KW
  3. nucleus Source: HPA
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Membrane, Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134863959.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 246246Transmembrane and ubiquitin-like domain-containing protein 1PRO_0000114922Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei71 – 711Phosphothreonine1 Publication
Modified residuei92 – 921Phosphothreonine2 Publications
Modified residuei98 – 981Phosphoserine3 Publications

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ9BVT8.
PaxDbiQ9BVT8.
PeptideAtlasiQ9BVT8.
PRIDEiQ9BVT8.

PTM databases

PhosphoSiteiQ9BVT8.

Miscellaneous databases

PMAP-CutDBQ9BVT8.

Expressioni

Gene expression databases

BgeeiQ9BVT8.
CleanExiHS_TMUB1.
ExpressionAtlasiQ9BVT8. baseline.
GenevestigatoriQ9BVT8.

Organism-specific databases

HPAiHPA029429.

Interactioni

Subunit structurei

Interacts with EEF1A1.By similarity

Protein-protein interaction databases

BioGridi123686. 18 interactions.
STRINGi9606.ENSP00000297533.

Structurei

3D structure databases

ProteinModelPortaliQ9BVT8.
SMRiQ9BVT8. Positions 105-186.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini103 – 17674Ubiquitin-likePROSITE-ProRule annotationAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi18 – 2710Nuclear export signalSequence Analysis

Sequence similaritiesi

Contains 1 ubiquitin-like domain.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG69268.
GeneTreeiENSGT00390000014069.
HOGENOMiHOG000232067.
HOVERGENiHBG050920.
InParanoidiQ9BVT8.
OMAiCVLHCHI.
OrthoDBiEOG7TF7B5.
PhylomeDBiQ9BVT8.
TreeFamiTF329265.

Family and domain databases

InterProiIPR000626. Ubiquitin-like.
IPR029071. Ubiquitin-rel_dom.
[Graphical view]
PfamiPF00240. ubiquitin. 1 hit.
[Graphical view]
SMARTiSM00213. UBQ. 1 hit.
[Graphical view]
SUPFAMiSSF54236. SSF54236. 1 hit.
PROSITEiPS50053. UBIQUITIN_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9BVT8-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MTLIEGVGDE VTVLFSVLAC LLVLALAWVS THTAEGGDPL PQPSGTPTPS
60 70 80 90 100
QPSAAMAATD SMRGEAPGAE TPSLRHRGQA AQPEPSTGFT ATPPAPDSPQ
110 120 130 140 150
EPLVLRLKFL NDSEQVARAW PHDTIGSLKR TQFPGREQQV RLIYQGQLLG
160 170 180 190 200
DDTQTLGSLH LPPNCVLHCH VSTRVGPPNP PCPPGSEPGP SGLEIGSLLL
210 220 230 240
PLLLLLLLLL WYCQIQYRPF FPLTATLGLA GFTLLLSLLA FAMYRP
Length:246
Mass (Da):26,261
Last modified:June 1, 2001 - v1
Checksum:iE08E25A6B37665B3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY603380 mRNA. Translation: AAU00156.1.
AY037155 mRNA. Translation: AAK67645.1.
AY358481 mRNA. Translation: AAQ88845.1.
AK314035 mRNA. Translation: BAG36745.1.
AC010973 Genomic DNA. No translation available.
CH471173 Genomic DNA. Translation: EAW54030.1.
CH471173 Genomic DNA. Translation: EAW54032.1.
BC000936 mRNA. Translation: AAH00936.1.
BC033182 mRNA. Translation: AAH33182.1.
CCDSiCCDS5920.1.
RefSeqiNP_001129516.1. NM_001136044.1.
NP_113622.1. NM_031434.3.
UniGeneiHs.726215.

Genome annotation databases

EnsembliENST00000297533; ENSP00000297533; ENSG00000164897.
ENST00000392818; ENSP00000376565; ENSG00000164897.
ENST00000462940; ENSP00000417519; ENSG00000164897.
ENST00000476627; ENSP00000419214; ENSG00000164897.
ENST00000482202; ENSP00000418709; ENSG00000164897.
GeneIDi83590.
KEGGihsa:83590.
UCSCiuc003wjb.3. human.

Polymorphism databases

DMDMi34922062.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY603380 mRNA. Translation: AAU00156.1 .
AY037155 mRNA. Translation: AAK67645.1 .
AY358481 mRNA. Translation: AAQ88845.1 .
AK314035 mRNA. Translation: BAG36745.1 .
AC010973 Genomic DNA. No translation available.
CH471173 Genomic DNA. Translation: EAW54030.1 .
CH471173 Genomic DNA. Translation: EAW54032.1 .
BC000936 mRNA. Translation: AAH00936.1 .
BC033182 mRNA. Translation: AAH33182.1 .
CCDSi CCDS5920.1.
RefSeqi NP_001129516.1. NM_001136044.1.
NP_113622.1. NM_031434.3.
UniGenei Hs.726215.

3D structure databases

ProteinModelPortali Q9BVT8.
SMRi Q9BVT8. Positions 105-186.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 123686. 18 interactions.
STRINGi 9606.ENSP00000297533.

PTM databases

PhosphoSitei Q9BVT8.

Polymorphism databases

DMDMi 34922062.

Proteomic databases

MaxQBi Q9BVT8.
PaxDbi Q9BVT8.
PeptideAtlasi Q9BVT8.
PRIDEi Q9BVT8.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000297533 ; ENSP00000297533 ; ENSG00000164897 .
ENST00000392818 ; ENSP00000376565 ; ENSG00000164897 .
ENST00000462940 ; ENSP00000417519 ; ENSG00000164897 .
ENST00000476627 ; ENSP00000419214 ; ENSG00000164897 .
ENST00000482202 ; ENSP00000418709 ; ENSG00000164897 .
GeneIDi 83590.
KEGGi hsa:83590.
UCSCi uc003wjb.3. human.

Organism-specific databases

CTDi 83590.
GeneCardsi GC07M150778.
HGNCi HGNC:21709. TMUB1.
HPAi HPA029429.
MIMi 614792. gene.
neXtProti NX_Q9BVT8.
PharmGKBi PA134863959.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG69268.
GeneTreei ENSGT00390000014069.
HOGENOMi HOG000232067.
HOVERGENi HBG050920.
InParanoidi Q9BVT8.
OMAi CVLHCHI.
OrthoDBi EOG7TF7B5.
PhylomeDBi Q9BVT8.
TreeFami TF329265.

Miscellaneous databases

ChiTaRSi TMUB1. human.
GenomeRNAii 83590.
NextBioi 72505.
PMAP-CutDB Q9BVT8.
PROi Q9BVT8.
SOURCEi Search...

Gene expression databases

Bgeei Q9BVT8.
CleanExi HS_TMUB1.
ExpressionAtlasi Q9BVT8. baseline.
Genevestigatori Q9BVT8.

Family and domain databases

InterProi IPR000626. Ubiquitin-like.
IPR029071. Ubiquitin-rel_dom.
[Graphical view ]
Pfami PF00240. ubiquitin. 1 hit.
[Graphical view ]
SMARTi SM00213. UBQ. 1 hit.
[Graphical view ]
SUPFAMi SSF54236. SSF54236. 1 hit.
PROSITEi PS50053. UBIQUITIN_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "HOPS: a novel cAMP-dependent shuttling protein involved in protein synthesis regulation."
    Della Fazia M.A., Castelli M., Bartoli D., Pieroni S., Pettirossi V., Piobbico D., Viola-Magni M., Servillo G.
    J. Cell Sci. 118:3185-3194(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Cloning and characterization of DULP, a novel ubiquitin-like molecule from human dendritic cells."
    Liu G.Y., Liu S.X., Li P., Tang L., Han Y.M., An H.Z., Li J.Y., Dai X.K., Li N., Cao X.T., Yu Y.Z.
    Cell. Mol. Immunol. 6:27-33(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], SUBCELLULAR LOCATION.
    Tissue: Dendritic cell.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  4. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  5. "The DNA sequence of human chromosome 7."
    Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H., Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K., Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A., Delehaunty K.D., Miner T.L.
    , Nash W.E., Cordes M., Du H., Sun H., Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A., Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P., Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M., Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S., Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R., Strowmatt C., Latreille P., Miller N., Johnson D., Murray J., Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W., Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A., Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E., Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E., Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A., Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A., Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R., McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H., Wilson R.K.
    Nature 424:157-164(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Kidney and Placenta.
  8. "Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."
    Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R., Greff Z., Keri G., Stemmann O., Mann M.
    Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-98, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  9. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-71; THR-92 AND SER-98, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  10. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
    Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
    Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-92 AND SER-98, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.

Entry informationi

Entry nameiTMUB1_HUMAN
AccessioniPrimary (citable) accession number: Q9BVT8
Secondary accession number(s): D3DX06, Q53AQ2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 19, 2003
Last sequence update: June 1, 2001
Last modified: October 29, 2014
This is version 107 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3