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Q9BVS4

- RIOK2_HUMAN

UniProt

Q9BVS4 - RIOK2_HUMAN

Protein

Serine/threonine-protein kinase RIO2

Gene

RIOK2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
    • BLAST
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    • History
      Entry version 120 (01 Oct 2014)
      Sequence version 2 (03 Apr 2007)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + a protein = ADP + a phosphoprotein.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei123 – 1231ATPBy similarity
    Active sitei228 – 2281Proton acceptorBy similarity

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. protein serine/threonine kinase activity Source: UniProtKB-KW

    Keywords - Molecular functioni

    Kinase, Serine/threonine-protein kinase, Transferase

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Serine/threonine-protein kinase RIO2 (EC:2.7.11.1)
    Alternative name(s):
    RIO kinase 2
    Gene namesi
    Name:RIOK2
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 5

    Organism-specific databases

    HGNCiHGNC:18999. RIOK2.

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA134885533.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 552552Serine/threonine-protein kinase RIO2PRO_0000213527Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei332 – 3321Phosphoserine4 Publications
    Modified residuei335 – 3351Phosphoserine4 Publications
    Modified residuei337 – 3371Phosphoserine5 Publications
    Modified residuei350 – 3501Phosphoserine1 Publication
    Modified residuei362 – 3621Phosphoserine1 Publication
    Modified residuei380 – 3801Phosphoserine2 Publications
    Modified residuei382 – 3821Phosphoserine2 Publications
    Modified residuei385 – 3851Phosphoserine3 Publications
    Modified residuei390 – 3901Phosphoserine4 Publications
    Modified residuei412 – 4121Phosphoserine1 Publication
    Modified residuei417 – 4171Phosphoserine1 Publication
    Modified residuei442 – 4421Phosphoserine3 Publications
    Modified residuei445 – 4451Phosphotyrosine1 Publication

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    MaxQBiQ9BVS4.
    PaxDbiQ9BVS4.
    PRIDEiQ9BVS4.

    PTM databases

    PhosphoSiteiQ9BVS4.

    Expressioni

    Gene expression databases

    ArrayExpressiQ9BVS4.
    BgeeiQ9BVS4.
    CleanExiHS_RIOK2.
    GenevestigatoriQ9BVS4.

    Organism-specific databases

    HPAiHPA005681.

    Interactioni

    Protein-protein interaction databases

    BioGridi120896. 25 interactions.
    IntActiQ9BVS4. 18 interactions.
    STRINGi9606.ENSP00000283109.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9BVS4.
    SMRiQ9BVS4. Positions 3-314.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini271 – 552282Protein kinaseAdd
    BLAST

    Sequence similaritiesi

    Contains 1 protein kinase domain.Curated

    Phylogenomic databases

    eggNOGiCOG0478.
    HOGENOMiHOG000225685.
    HOVERGENiHBG056045.
    InParanoidiQ9BVS4.
    KOiK07179.
    OMAiVAKLRYM.
    OrthoDBiEOG754HP9.
    PhylomeDBiQ9BVS4.
    TreeFamiTF321400.

    Family and domain databases

    Gene3Di1.10.10.10. 1 hit.
    InterProiIPR011009. Kinase-like_dom.
    IPR018934. RIO-like_kinase.
    IPR015285. RIO2_kinase_winged_hlx_N.
    IPR018935. RIO_kinase_CS.
    IPR011991. WHTH_DNA-bd_dom.
    [Graphical view]
    PfamiPF01163. RIO1. 1 hit.
    PF09202. Rio2_N. 1 hit.
    [Graphical view]
    SUPFAMiSSF56112. SSF56112. 1 hit.
    PROSITEiPS01245. RIO1. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q9BVS4-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MGKVNVAKLR YMSRDDFRVL TAVEMGMKNH EIVPGSLIAS IASLKHGGCN    50
    KVLRELVKHK LIAWERTKTV QGYRLTNAGY DYLALKTLSS RQVVESVGNQ 100
    MGVGKESDIY IVANEEGQQF ALKLHRLGRT SFRNLKNKRD YHKHRHNVSW 150
    LYLSRLSAMK EFAYMKALYE RKFPVPKPID YNRHAVVMEL INGYPLCQIH 200
    HVEDPASVYD EAMELIVKLA NHGLIHGDFN EFNLILDESD HITMIDFPQM 250
    VSTSHPNAEW YFDRDVKCIK DFFMKRFSYE SELFPTFKDI RREDTLDVEV 300
    SASGYTKEMQ ADDELLHPLG PDDKNIETKE GSEFSFSDGE VAEKAEVYGS 350
    ENESERNCLE ESEGCYCRSS GDPEQIKEDS LSEESADARS FEMTEFNQAL 400
    EEIKGQVVEN NSVTEFSEEK NRTENYNRQD GQRVQGGVPA GSDEYEDECP 450
    HLIALSSLNR EFRPFRDEEN VGAMNQYRTR TLSITSSGSA VSCSTIPPEL 500
    VKQKVKRQLT KQQKSAVRRR LQKGEANIFT KQRRENMQNI KSSLEAASFW 550
    GE 552
    Length:552
    Mass (Da):63,283
    Last modified:April 3, 2007 - v2
    Checksum:i6EB260E72DDB78D7
    GO
    Isoform 2 (identifier: Q9BVS4-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         467-552: DEENVGAMNQ...SLEAASFWGE → YRLLSIAF

    Note: No experimental confirmation available.

    Show »
    Length:474
    Mass (Da):54,508
    Checksum:i4B396021BE81BE84
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti96 – 961S → C.1 Publication
    Corresponds to variant rs2544773 [ dbSNP | Ensembl ].
    VAR_042347
    Natural varianti144 – 1441H → R.1 Publication
    Corresponds to variant rs35165987 [ dbSNP | Ensembl ].
    VAR_042348
    Natural varianti144 – 1441H → Y.1 Publication
    Corresponds to variant rs17849382 [ dbSNP | Ensembl ].
    VAR_031597
    Natural varianti155 – 1551R → H.1 Publication
    Corresponds to variant rs34916955 [ dbSNP | Ensembl ].
    VAR_042349
    Natural varianti175 – 1751V → I.1 Publication
    Corresponds to variant rs35713904 [ dbSNP | Ensembl ].
    VAR_042350
    Natural varianti216 – 2161I → T in a renal clear cell carcinoma sample; somatic mutation. 1 Publication
    VAR_042351
    Natural varianti244 – 2441M → V.1 Publication
    Corresponds to variant rs33996030 [ dbSNP | Ensembl ].
    VAR_042352
    Natural varianti349 – 3491G → R.2 Publications
    Corresponds to variant rs160632 [ dbSNP | Ensembl ].
    VAR_031598
    Natural varianti397 – 3971N → S.1 Publication
    Corresponds to variant rs12188395 [ dbSNP | Ensembl ].
    VAR_031599
    Natural varianti409 – 4091E → D.1 Publication
    Corresponds to variant rs35829000 [ dbSNP | Ensembl ].
    VAR_042353
    Natural varianti507 – 5071R → H.1 Publication
    Corresponds to variant rs34555783 [ dbSNP | Ensembl ].
    VAR_042354

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei467 – 55286DEENV…SFWGE → YRLLSIAF in isoform 2. 1 PublicationVSP_046388Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK002021 mRNA. Translation: BAA92040.1.
    AK225348 mRNA. No translation available.
    AC008865 Genomic DNA. No translation available.
    AC008883 Genomic DNA. No translation available.
    BC000953 mRNA. Translation: AAH00953.1.
    CCDSiCCDS4089.1. [Q9BVS4-1]
    CCDS54884.1. [Q9BVS4-2]
    RefSeqiNP_001153221.1. NM_001159749.1. [Q9BVS4-2]
    NP_060813.2. NM_018343.2. [Q9BVS4-1]
    UniGeneiHs.27021.

    Genome annotation databases

    EnsembliENST00000283109; ENSP00000283109; ENSG00000058729. [Q9BVS4-1]
    ENST00000508447; ENSP00000420932; ENSG00000058729. [Q9BVS4-2]
    GeneIDi55781.
    KEGGihsa:55781.
    UCSCiuc003kmz.3. human. [Q9BVS4-1]

    Polymorphism databases

    DMDMi143811448.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK002021 mRNA. Translation: BAA92040.1 .
    AK225348 mRNA. No translation available.
    AC008865 Genomic DNA. No translation available.
    AC008883 Genomic DNA. No translation available.
    BC000953 mRNA. Translation: AAH00953.1 .
    CCDSi CCDS4089.1. [Q9BVS4-1 ]
    CCDS54884.1. [Q9BVS4-2 ]
    RefSeqi NP_001153221.1. NM_001159749.1. [Q9BVS4-2 ]
    NP_060813.2. NM_018343.2. [Q9BVS4-1 ]
    UniGenei Hs.27021.

    3D structure databases

    ProteinModelPortali Q9BVS4.
    SMRi Q9BVS4. Positions 3-314.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 120896. 25 interactions.
    IntActi Q9BVS4. 18 interactions.
    STRINGi 9606.ENSP00000283109.

    Chemistry

    BindingDBi Q9BVS4.
    ChEMBLi CHEMBL6000.
    GuidetoPHARMACOLOGYi 2187.

    PTM databases

    PhosphoSitei Q9BVS4.

    Polymorphism databases

    DMDMi 143811448.

    Proteomic databases

    MaxQBi Q9BVS4.
    PaxDbi Q9BVS4.
    PRIDEi Q9BVS4.

    Protocols and materials databases

    DNASUi 55781.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000283109 ; ENSP00000283109 ; ENSG00000058729 . [Q9BVS4-1 ]
    ENST00000508447 ; ENSP00000420932 ; ENSG00000058729 . [Q9BVS4-2 ]
    GeneIDi 55781.
    KEGGi hsa:55781.
    UCSCi uc003kmz.3. human. [Q9BVS4-1 ]

    Organism-specific databases

    CTDi 55781.
    GeneCardsi GC05M096496.
    HGNCi HGNC:18999. RIOK2.
    HPAi HPA005681.
    neXtProti NX_Q9BVS4.
    PharmGKBi PA134885533.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG0478.
    HOGENOMi HOG000225685.
    HOVERGENi HBG056045.
    InParanoidi Q9BVS4.
    KOi K07179.
    OMAi VAKLRYM.
    OrthoDBi EOG754HP9.
    PhylomeDBi Q9BVS4.
    TreeFami TF321400.

    Miscellaneous databases

    GenomeRNAii 55781.
    NextBioi 60867.
    PROi Q9BVS4.

    Gene expression databases

    ArrayExpressi Q9BVS4.
    Bgeei Q9BVS4.
    CleanExi HS_RIOK2.
    Genevestigatori Q9BVS4.

    Family and domain databases

    Gene3Di 1.10.10.10. 1 hit.
    InterProi IPR011009. Kinase-like_dom.
    IPR018934. RIO-like_kinase.
    IPR015285. RIO2_kinase_winged_hlx_N.
    IPR018935. RIO_kinase_CS.
    IPR011991. WHTH_DNA-bd_dom.
    [Graphical view ]
    Pfami PF01163. RIO1. 1 hit.
    PF09202. Rio2_N. 1 hit.
    [Graphical view ]
    SUPFAMi SSF56112. SSF56112. 1 hit.
    PROSITEi PS01245. RIO1. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT ARG-349.
      Tissue: Placenta.
    2. Suzuki Y., Sugano S., Totoki Y., Toyoda A., Takeda T., Sakaki Y., Tanaka A., Yokoyama S.
      Submitted (JUL-2006) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
      Tissue: Hepatoma.
    3. "The DNA sequence and comparative analysis of human chromosome 5."
      Schmutz J., Martin J., Terry A., Couronne O., Grimwood J., Lowry S., Gordon L.A., Scott D., Xie G., Huang W., Hellsten U., Tran-Gyamfi M., She X., Prabhakar S., Aerts A., Altherr M., Bajorek E., Black S.
      , Branscomb E., Caoile C., Challacombe J.F., Chan Y.M., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Glavina T., Gomez M., Gonzales E., Goodstein D., Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Lopez F., Lou Y., Martinez D., Medina C., Morgan J., Nandkeshwar R., Noonan J.P., Pitluck S., Pollard M., Predki P., Priest J., Ramirez L., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wheeler J., Wu K., Yang J., Dickson M., Cheng J.-F., Eichler E.E., Olsen A., Pennacchio L.A., Rokhsar D.S., Richardson P., Lucas S.M., Myers R.M., Rubin E.M.
      Nature 431:268-274(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT TYR-144.
      Tissue: Placenta.
    5. "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."
      Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M.
      Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-390, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    6. "Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."
      Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R., Greff Z., Keri G., Stemmann O., Mann M.
      Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-332; SER-335; SER-337; SER-390; SER-417 AND SER-442, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    7. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-350; SER-380; SER-382; SER-385 AND SER-442, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    8. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
      Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
      Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    9. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-332; SER-335; SER-337; SER-362; SER-385; SER-390; SER-442 AND TYR-445, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    10. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
      Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
      Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-332; SER-335; SER-337; SER-380; SER-382; SER-385 AND SER-390, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Leukemic T-cell.
    11. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
      Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
      Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-332; SER-335; SER-337 AND SER-412, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    12. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    13. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
      Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
      Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-337, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    14. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    15. "Patterns of somatic mutation in human cancer genomes."
      Greenman C., Stephens P., Smith R., Dalgliesh G.L., Hunter C., Bignell G., Davies H., Teague J., Butler A., Stevens C., Edkins S., O'Meara S., Vastrik I., Schmidt E.E., Avis T., Barthorpe S., Bhamra G., Buck G.
      , Choudhury B., Clements J., Cole J., Dicks E., Forbes S., Gray K., Halliday K., Harrison R., Hills K., Hinton J., Jenkinson A., Jones D., Menzies A., Mironenko T., Perry J., Raine K., Richardson D., Shepherd R., Small A., Tofts C., Varian J., Webb T., West S., Widaa S., Yates A., Cahill D.P., Louis D.N., Goldstraw P., Nicholson A.G., Brasseur F., Looijenga L., Weber B.L., Chiew Y.-E., DeFazio A., Greaves M.F., Green A.R., Campbell P., Birney E., Easton D.F., Chenevix-Trench G., Tan M.-H., Khoo S.K., Teh B.T., Yuen S.T., Leung S.Y., Wooster R., Futreal P.A., Stratton M.R.
      Nature 446:153-158(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: VARIANTS [LARGE SCALE ANALYSIS] CYS-96; ARG-144; HIS-155; ILE-175; THR-216; VAL-244; ARG-349; SER-397; ASP-409 AND HIS-507.

    Entry informationi

    Entry nameiRIOK2_HUMAN
    AccessioniPrimary (citable) accession number: Q9BVS4
    Secondary accession number(s): D6RDI3, Q9NUT0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 7, 2004
    Last sequence update: April 3, 2007
    Last modified: October 1, 2014
    This is version 120 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 5
      Human chromosome 5: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. Human and mouse protein kinases
      Human and mouse protein kinases: classification and index
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3