ID   HRC23_HUMAN             Reviewed;        1158 AA.
AC   Q9BVR0;
DT   02-SEP-2008, integrated into UniProtKB/Swiss-Prot.
DT   02-SEP-2008, sequence version 2.
DT   27-MAR-2024, entry version 96.
DE   RecName: Full=Putative HERC2-like protein 3;
GN   Name=HERC2P3;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16572171; DOI=10.1038/nature04601;
RA   Zody M.C., Garber M., Sharpe T., Young S.K., Rowen L., O'Neill K.,
RA   Whittaker C.A., Kamal M., Chang J.L., Cuomo C.A., Dewar K.,
RA   FitzGerald M.G., Kodira C.D., Madan A., Qin S., Yang X., Abbasi N.,
RA   Abouelleil A., Arachchi H.M., Baradarani L., Birditt B., Bloom S.,
RA   Bloom T., Borowsky M.L., Burke J., Butler J., Cook A., DeArellano K.,
RA   DeCaprio D., Dorris L. III, Dors M., Eichler E.E., Engels R., Fahey J.,
RA   Fleetwood P., Friedman C., Gearin G., Hall J.L., Hensley G., Johnson E.,
RA   Jones C., Kamat A., Kaur A., Locke D.P., Madan A., Munson G., Jaffe D.B.,
RA   Lui A., Macdonald P., Mauceli E., Naylor J.W., Nesbitt R., Nicol R.,
RA   O'Leary S.B., Ratcliffe A., Rounsley S., She X., Sneddon K.M.B.,
RA   Stewart S., Sougnez C., Stone S.M., Topham K., Vincent D., Wang S.,
RA   Zimmer A.R., Birren B.W., Hood L., Lander E.S., Nusbaum C.;
RT   "Analysis of the DNA sequence and duplication history of human chromosome
RT   15.";
RL   Nature 440:671-675(2006).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Placenta, and Testis;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- CAUTION: Could be the product of a pseudogene. {ECO:0000305}.
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DR   EMBL; AC026495; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; BC000975; -; NOT_ANNOTATED_CDS; mRNA.
DR   EMBL; BC070076; -; NOT_ANNOTATED_CDS; mRNA.
DR   AlphaFoldDB; Q9BVR0; -.
DR   SMR; Q9BVR0; -.
DR   iPTMnet; Q9BVR0; -.
DR   PhosphoSitePlus; Q9BVR0; -.
DR   BioMuta; HGNC:4871; -.
DR   EPD; Q9BVR0; -.
DR   jPOST; Q9BVR0; -.
DR   MassIVE; Q9BVR0; -.
DR   MaxQB; Q9BVR0; -.
DR   PeptideAtlas; Q9BVR0; -.
DR   ProteomicsDB; 79229; -.
DR   AGR; HGNC:4871; -.
DR   GeneCards; HERC2P3; -.
DR   HGNC; HGNC:4871; HERC2P3.
DR   neXtProt; NX_Q9BVR0; -.
DR   InParanoid; Q9BVR0; -.
DR   SignaLink; Q9BVR0; -.
DR   ChiTaRS; HERC2P3; human.
DR   Pharos; Q9BVR0; Tdark.
DR   Proteomes; UP000005640; Unplaced.
DR   RNAct; Q9BVR0; Protein.
DR   GO; GO:0046872; F:metal ion binding; IEA:InterPro.
DR   GO; GO:0061630; F:ubiquitin protein ligase activity; IBA:GO_Central.
DR   GO; GO:0016567; P:protein ubiquitination; IEA:InterPro.
DR   Gene3D; 2.30.30.40; SH3 Domains; 1.
DR   InterPro; IPR010606; Mib_Herc2.
DR   InterPro; IPR037252; Mib_Herc2_sf.
DR   PANTHER; PTHR24202:SF53; E3 UBIQUITIN-PROTEIN LIGASE MIB1-RELATED; 1.
DR   PANTHER; PTHR24202; E3 UBIQUITIN-PROTEIN LIGASE MIB2; 1.
DR   Pfam; PF06701; MIB_HERC2; 1.
DR   SUPFAM; SSF159034; Mib/herc2 domain-like; 1.
DR   PROSITE; PS51416; MIB_HERC2; 1.
PE   5: Uncertain;
KW   Reference proteome.
FT   CHAIN           1..1158
FT                   /note="Putative HERC2-like protein 3"
FT                   /id="PRO_0000349290"
FT   DOMAIN          587..660
FT                   /note="MIB/HERC2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00749"
FT   REGION          281..302
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          662..684
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   VARIANT         759
FT                   /note="L -> P (in dbSNP:rs17134681)"
FT                   /id="VAR_046344"
FT   VARIANT         1119
FT                   /note="R -> I (in dbSNP:rs4931826)"
FT                   /id="VAR_046345"
FT   CONFLICT        278
FT                   /note="I -> V (in Ref. 2; BC070076)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   1158 AA;  128943 MW;  A1F748BFC0E70C27 CRC64;
     MHAFCVGQYL EPDQEGVTIP DLGSLSSPLI DTERNLGLLL GLHASYLAMS TPLSPVEIEC
     AKWLQSSIFS GGLQTSQIHY SYNEEKDEDH CSSPGGTPAS KSRLCSHRRA LGDHSQAFLQ
     AIADNNIQDH NVKDFLCQIE RYCRQCHLTT PIMFPPEHPV EEVGRLLLCC LLKHEDLGHV
     ALSLVHAGAL GIEQVKHRTL PKSVVDVCRV VYQAKCSLIK THQEQGRSYK EVCAPVIERL
     RFLFNELRPA VCNDLSIMSK FKLLSSLPHW RRIAQKIIRE PRKKRVPKKP ESTDDEEKIG
     NEESDLEEAC ILPHSPINVD KRPIAIKSPK DKWQPLLSTV TGVHKYKWLK QNVQGLYPQS
     PLLSTIAEFA LKEEPVDVEK RKCLLKQLER AEVRLEGIDT ILKLYLVSKN FLLPSVPYAM
     FCGWQRLIPE GIDIGEPLTD CLKDVDLIPP FNRMLLEVTF GKLYAWAVQN IRNVLVDASA
     KFKELGIQPV PLQTITNENP SGPSLGTIPQ AHFLLVMLSM LTLQHSANNL DLLLNSGTLA
     LAQTALRLIG PSCDSVEEDM NASAQGASAT VLEETRKETA PVQLPVSGPE LAAMMKIGTR
     VMRGVDWKWG DQDRPPPGLG RVIGELGEDG WIRVQWDTGS TNSYRMGKEG NYDLKLAELP
     APAQPSAEDS DTEDDSEAEQ TERNIHPTAM MFTSTINLLQ TLCLSAGVHA EIMQSEATKT
     LCGLLQMLVY REQHRSWCTL GFVQSIALTL QVCGTLSSLQ WITLLMKVVE GHAPFTATSL
     QRQILAVHLL QAVLPSWDKT ERARDMKCLM EKLFDFLGSL LTMCSSDVPL LRESTLRRRR
     VCPQASLTAT HSSTLAEEVV ALLHTLHSLT QWNGLINKYI NSQLRSITHS FAGRPSKGAQ
     LEDYFPDSEN PEVGGLMAVL AVVGGIDGRL CLGGQVVHDD FGEVTMTRIT LKGKITVQFS
     DMRTCHVCPL NQLKPLPAVA FNVNNLPFTE PMLSVWAQLV NLAGSKLEKH KIKKSTKQAF
     AGQVDLDLLR CQQLKLYILK AGRALFSHQD KLRQILSQPA VQETGTVHTD DGAVVSPDLG
     DMSPEGPQPP MILLQQLLAS ATQPSPVKAI FDKQELEERM SRCCFWRRRT TKLEQILLFI
     RRMNSVCEKE NTNATASN
//