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Q9BVR0 (HRC23_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 64. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (4) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Putative HERC2-like protein 3
Gene names
Name:HERC2P3
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length1158 AA.
Sequence statusComplete.
Protein existenceUncertain

General annotation (Comments)

Sequence similarities

Contains 1 MIB/HERC2 domain.

Caution

Could be the product of a pseudogene.

Ontologies

Keywords
   Coding sequence diversityPolymorphism
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Molecular_functionmetal ion binding

Inferred from electronic annotation. Source: InterPro

ubiquitin-protein transferase activity

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 11581158Putative HERC2-like protein 3
PRO_0000349290

Regions

Domain587 – 66074MIB/HERC2
Compositional bias837 – 8404Poly-Arg

Natural variations

Natural variant7591L → P.
Corresponds to variant rs17134681 [ dbSNP | Ensembl ].
VAR_046344
Natural variant11191R → I.
Corresponds to variant rs4931826 [ dbSNP | Ensembl ].
VAR_046345

Experimental info

Sequence conflict2781I → V in BC070076. Ref.2

Sequences

Sequence LengthMass (Da)Tools
Q9BVR0 [UniParc].

Last modified September 2, 2008. Version 2.
Checksum: A1F748BFC0E70C27

FASTA1,158128,943
        10         20         30         40         50         60 
MHAFCVGQYL EPDQEGVTIP DLGSLSSPLI DTERNLGLLL GLHASYLAMS TPLSPVEIEC 

        70         80         90        100        110        120 
AKWLQSSIFS GGLQTSQIHY SYNEEKDEDH CSSPGGTPAS KSRLCSHRRA LGDHSQAFLQ 

       130        140        150        160        170        180 
AIADNNIQDH NVKDFLCQIE RYCRQCHLTT PIMFPPEHPV EEVGRLLLCC LLKHEDLGHV 

       190        200        210        220        230        240 
ALSLVHAGAL GIEQVKHRTL PKSVVDVCRV VYQAKCSLIK THQEQGRSYK EVCAPVIERL 

       250        260        270        280        290        300 
RFLFNELRPA VCNDLSIMSK FKLLSSLPHW RRIAQKIIRE PRKKRVPKKP ESTDDEEKIG 

       310        320        330        340        350        360 
NEESDLEEAC ILPHSPINVD KRPIAIKSPK DKWQPLLSTV TGVHKYKWLK QNVQGLYPQS 

       370        380        390        400        410        420 
PLLSTIAEFA LKEEPVDVEK RKCLLKQLER AEVRLEGIDT ILKLYLVSKN FLLPSVPYAM 

       430        440        450        460        470        480 
FCGWQRLIPE GIDIGEPLTD CLKDVDLIPP FNRMLLEVTF GKLYAWAVQN IRNVLVDASA 

       490        500        510        520        530        540 
KFKELGIQPV PLQTITNENP SGPSLGTIPQ AHFLLVMLSM LTLQHSANNL DLLLNSGTLA 

       550        560        570        580        590        600 
LAQTALRLIG PSCDSVEEDM NASAQGASAT VLEETRKETA PVQLPVSGPE LAAMMKIGTR 

       610        620        630        640        650        660 
VMRGVDWKWG DQDRPPPGLG RVIGELGEDG WIRVQWDTGS TNSYRMGKEG NYDLKLAELP 

       670        680        690        700        710        720 
APAQPSAEDS DTEDDSEAEQ TERNIHPTAM MFTSTINLLQ TLCLSAGVHA EIMQSEATKT 

       730        740        750        760        770        780 
LCGLLQMLVY REQHRSWCTL GFVQSIALTL QVCGTLSSLQ WITLLMKVVE GHAPFTATSL 

       790        800        810        820        830        840 
QRQILAVHLL QAVLPSWDKT ERARDMKCLM EKLFDFLGSL LTMCSSDVPL LRESTLRRRR 

       850        860        870        880        890        900 
VCPQASLTAT HSSTLAEEVV ALLHTLHSLT QWNGLINKYI NSQLRSITHS FAGRPSKGAQ 

       910        920        930        940        950        960 
LEDYFPDSEN PEVGGLMAVL AVVGGIDGRL CLGGQVVHDD FGEVTMTRIT LKGKITVQFS 

       970        980        990       1000       1010       1020 
DMRTCHVCPL NQLKPLPAVA FNVNNLPFTE PMLSVWAQLV NLAGSKLEKH KIKKSTKQAF 

      1030       1040       1050       1060       1070       1080 
AGQVDLDLLR CQQLKLYILK AGRALFSHQD KLRQILSQPA VQETGTVHTD DGAVVSPDLG 

      1090       1100       1110       1120       1130       1140 
DMSPEGPQPP MILLQQLLAS ATQPSPVKAI FDKQELEERM SRCCFWRRRT TKLEQILLFI 

      1150 
RRMNSVCEKE NTNATASN 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AC026495 Genomic DNA. No translation available.
BC000975 mRNA. No translation available.
BC070076 mRNA. No translation available.
UniGeneHs.608918.

3D structure databases

ProteinModelPortalQ9BVR0.
SMRQ9BVR0. Positions 595-657.
ModBaseSearch...
MobiDBSearch...

PTM databases

PhosphoSiteQ9BVR0.

Proteomic databases

MaxQBQ9BVR0.
PRIDEQ9BVR0.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

UCSCuc001ytg.3. human.

Organism-specific databases

GeneCardsGC15M020589.
HGNCHGNC:4871. HERC2P3.
HPACAB017188.
neXtProtNX_Q9BVR0.
GenAtlasSearch...

Phylogenomic databases

HOVERGENHBG105898.
InParanoidQ9BVR0.

Gene expression databases

GenevestigatorQ9BVR0.

Family and domain databases

InterProIPR010606. Mib_Herc2.
[Graphical view]
PfamPF06701. MIB_HERC2. 1 hit.
[Graphical view]
PROSITEPS51416. MIB_HERC2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameHRC23_HUMAN
AccessionPrimary (citable) accession number: Q9BVR0
Entry history
Integrated into UniProtKB/Swiss-Prot: September 2, 2008
Last sequence update: September 2, 2008
Last modified: May 14, 2014
This is version 64 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 15

Human chromosome 15: entries, gene names and cross-references to MIM