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Q9BVR0

- HRC23_HUMAN

UniProt

Q9BVR0 - HRC23_HUMAN

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Protein

Putative HERC2-like protein 3

Gene

HERC2P3

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 2 out of 5- Protein uncertaini

Functioni

GO - Molecular functioni

  1. metal ion binding Source: InterPro
  2. ubiquitin-protein transferase activity Source: InterPro
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Putative HERC2-like protein 3
Gene namesi
Name:HERC2P3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Unplaced

Organism-specific databases

HGNCiHGNC:4871. HERC2P3.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 11581158Putative HERC2-like protein 3PRO_0000349290Add
BLAST

Proteomic databases

MaxQBiQ9BVR0.
PRIDEiQ9BVR0.

PTM databases

PhosphoSiteiQ9BVR0.

Expressioni

Gene expression databases

GenevestigatoriQ9BVR0.

Organism-specific databases

HPAiCAB017188.

Structurei

3D structure databases

ProteinModelPortaliQ9BVR0.
SMRiQ9BVR0. Positions 595-657.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini587 – 66074MIB/HERC2PROSITE-ProRule annotationAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi837 – 8404Poly-Arg

Sequence similaritiesi

Contains 1 MIB/HERC2 domain.PROSITE-ProRule annotation

Phylogenomic databases

HOVERGENiHBG105898.
InParanoidiQ9BVR0.

Family and domain databases

InterProiIPR010606. Mib_Herc2.
[Graphical view]
PfamiPF06701. MIB_HERC2. 1 hit.
[Graphical view]
PROSITEiPS51416. MIB_HERC2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9BVR0-1 [UniParc]FASTAAdd to Basket

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        10         20         30         40         50
MHAFCVGQYL EPDQEGVTIP DLGSLSSPLI DTERNLGLLL GLHASYLAMS
60 70 80 90 100
TPLSPVEIEC AKWLQSSIFS GGLQTSQIHY SYNEEKDEDH CSSPGGTPAS
110 120 130 140 150
KSRLCSHRRA LGDHSQAFLQ AIADNNIQDH NVKDFLCQIE RYCRQCHLTT
160 170 180 190 200
PIMFPPEHPV EEVGRLLLCC LLKHEDLGHV ALSLVHAGAL GIEQVKHRTL
210 220 230 240 250
PKSVVDVCRV VYQAKCSLIK THQEQGRSYK EVCAPVIERL RFLFNELRPA
260 270 280 290 300
VCNDLSIMSK FKLLSSLPHW RRIAQKIIRE PRKKRVPKKP ESTDDEEKIG
310 320 330 340 350
NEESDLEEAC ILPHSPINVD KRPIAIKSPK DKWQPLLSTV TGVHKYKWLK
360 370 380 390 400
QNVQGLYPQS PLLSTIAEFA LKEEPVDVEK RKCLLKQLER AEVRLEGIDT
410 420 430 440 450
ILKLYLVSKN FLLPSVPYAM FCGWQRLIPE GIDIGEPLTD CLKDVDLIPP
460 470 480 490 500
FNRMLLEVTF GKLYAWAVQN IRNVLVDASA KFKELGIQPV PLQTITNENP
510 520 530 540 550
SGPSLGTIPQ AHFLLVMLSM LTLQHSANNL DLLLNSGTLA LAQTALRLIG
560 570 580 590 600
PSCDSVEEDM NASAQGASAT VLEETRKETA PVQLPVSGPE LAAMMKIGTR
610 620 630 640 650
VMRGVDWKWG DQDRPPPGLG RVIGELGEDG WIRVQWDTGS TNSYRMGKEG
660 670 680 690 700
NYDLKLAELP APAQPSAEDS DTEDDSEAEQ TERNIHPTAM MFTSTINLLQ
710 720 730 740 750
TLCLSAGVHA EIMQSEATKT LCGLLQMLVY REQHRSWCTL GFVQSIALTL
760 770 780 790 800
QVCGTLSSLQ WITLLMKVVE GHAPFTATSL QRQILAVHLL QAVLPSWDKT
810 820 830 840 850
ERARDMKCLM EKLFDFLGSL LTMCSSDVPL LRESTLRRRR VCPQASLTAT
860 870 880 890 900
HSSTLAEEVV ALLHTLHSLT QWNGLINKYI NSQLRSITHS FAGRPSKGAQ
910 920 930 940 950
LEDYFPDSEN PEVGGLMAVL AVVGGIDGRL CLGGQVVHDD FGEVTMTRIT
960 970 980 990 1000
LKGKITVQFS DMRTCHVCPL NQLKPLPAVA FNVNNLPFTE PMLSVWAQLV
1010 1020 1030 1040 1050
NLAGSKLEKH KIKKSTKQAF AGQVDLDLLR CQQLKLYILK AGRALFSHQD
1060 1070 1080 1090 1100
KLRQILSQPA VQETGTVHTD DGAVVSPDLG DMSPEGPQPP MILLQQLLAS
1110 1120 1130 1140 1150
ATQPSPVKAI FDKQELEERM SRCCFWRRRT TKLEQILLFI RRMNSVCEKE

NTNATASN
Length:1,158
Mass (Da):128,943
Last modified:September 2, 2008 - v2
Checksum:iA1F748BFC0E70C27
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti278 – 2781I → V in BC070076. (PubMed:15489334)Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti759 – 7591L → P.
Corresponds to variant rs17134681 [ dbSNP | Ensembl ].
VAR_046344
Natural varianti1119 – 11191R → I.
Corresponds to variant rs4931826 [ dbSNP | Ensembl ].
VAR_046345

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AC026495 Genomic DNA. No translation available.
BC000975 mRNA. No translation available.
BC070076 mRNA. No translation available.
UniGeneiHs.608918.

Genome annotation databases

UCSCiuc001ytg.3. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AC026495 Genomic DNA. No translation available.
BC000975 mRNA. No translation available.
BC070076 mRNA. No translation available.
UniGenei Hs.608918.

3D structure databases

ProteinModelPortali Q9BVR0.
SMRi Q9BVR0. Positions 595-657.
ModBasei Search...
MobiDBi Search...

PTM databases

PhosphoSitei Q9BVR0.

Proteomic databases

MaxQBi Q9BVR0.
PRIDEi Q9BVR0.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

UCSCi uc001ytg.3. human.

Organism-specific databases

GeneCardsi GC15M020589.
HGNCi HGNC:4871. HERC2P3.
HPAi CAB017188.
neXtProti NX_Q9BVR0.
GenAtlasi Search...

Phylogenomic databases

HOVERGENi HBG105898.
InParanoidi Q9BVR0.

Gene expression databases

Genevestigatori Q9BVR0.

Family and domain databases

InterProi IPR010606. Mib_Herc2.
[Graphical view ]
Pfami PF06701. MIB_HERC2. 1 hit.
[Graphical view ]
PROSITEi PS51416. MIB_HERC2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Analysis of the DNA sequence and duplication history of human chromosome 15."
    Zody M.C., Garber M., Sharpe T., Young S.K., Rowen L., O'Neill K., Whittaker C.A., Kamal M., Chang J.L., Cuomo C.A., Dewar K., FitzGerald M.G., Kodira C.D., Madan A., Qin S., Yang X., Abbasi N., Abouelleil A.
    , Arachchi H.M., Baradarani L., Birditt B., Bloom S., Bloom T., Borowsky M.L., Burke J., Butler J., Cook A., DeArellano K., DeCaprio D., Dorris L. III, Dors M., Eichler E.E., Engels R., Fahey J., Fleetwood P., Friedman C., Gearin G., Hall J.L., Hensley G., Johnson E., Jones C., Kamat A., Kaur A., Locke D.P., Madan A., Munson G., Jaffe D.B., Lui A., Macdonald P., Mauceli E., Naylor J.W., Nesbitt R., Nicol R., O'Leary S.B., Ratcliffe A., Rounsley S., She X., Sneddon K.M.B., Stewart S., Sougnez C., Stone S.M., Topham K., Vincent D., Wang S., Zimmer A.R., Birren B.W., Hood L., Lander E.S., Nusbaum C.
    Nature 440:671-675(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Placenta and Testis.

Entry informationi

Entry nameiHRC23_HUMAN
AccessioniPrimary (citable) accession number: Q9BVR0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 2, 2008
Last sequence update: September 2, 2008
Last modified: October 1, 2014
This is version 66 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

Could be the product of a pseudogene.Curated

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 15
    Human chromosome 15: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3