Q9BVR0 (HRC23_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Putative HERC2-like protein 3

Gene names

Name:

HERC2P3

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	1158 AA.
Sequence status	Complete.
Protein existence	Uncertain

General annotation (Comments)

Sequence similarities	Contains 1 MIB/HERC2 domain.
Caution	Could be the product of a pseudogene.

Ontologies

Keywords
Coding sequence diversity	Polymorphism
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Molecular_function	metal ion binding Inferred from electronic annotation. Source: InterPro ubiquitin-protein ligase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 1158	1158	Putative HERC2-like protein 3		PRO_0000349290
Regions
	Domain	587 – 660	74	MIB/HERC2
	Compositional bias	837 – 840	4	Poly-Arg
Natural variations
	Natural variant	759	1	L → P. Corresponds to variant rs17134681 [ dbSNP | Ensembl ].		VAR_046344
	Natural variant	1119	1	R → I. Corresponds to variant rs4931826 [ dbSNP | Ensembl ].		VAR_046345
Experimental info
	Sequence conflict	278	1	I → V in BC070076. Ref.2

Sequences

	Sequence		Length	Mass (Da)
	Q9BVR0 [UniParc]. Last modified September 2, 2008. Version 2. Checksum: A1F748BFC0E70C27	FASTA	1,158	128,943
	10 20 30 40 50 60 MHAFCVGQYL EPDQEGVTIP DLGSLSSPLI DTERNLGLLL GLHASYLAMS TPLSPVEIEC 70 80 90 100 110 120 AKWLQSSIFS GGLQTSQIHY SYNEEKDEDH CSSPGGTPAS KSRLCSHRRA LGDHSQAFLQ 130 140 150 160 170 180 AIADNNIQDH NVKDFLCQIE RYCRQCHLTT PIMFPPEHPV EEVGRLLLCC LLKHEDLGHV 190 200 210 220 230 240 ALSLVHAGAL GIEQVKHRTL PKSVVDVCRV VYQAKCSLIK THQEQGRSYK EVCAPVIERL 250 260 270 280 290 300 RFLFNELRPA VCNDLSIMSK FKLLSSLPHW RRIAQKIIRE PRKKRVPKKP ESTDDEEKIG 310 320 330 340 350 360 NEESDLEEAC ILPHSPINVD KRPIAIKSPK DKWQPLLSTV TGVHKYKWLK QNVQGLYPQS 370 380 390 400 410 420 PLLSTIAEFA LKEEPVDVEK RKCLLKQLER AEVRLEGIDT ILKLYLVSKN FLLPSVPYAM 430 440 450 460 470 480 FCGWQRLIPE GIDIGEPLTD CLKDVDLIPP FNRMLLEVTF GKLYAWAVQN IRNVLVDASA 490 500 510 520 530 540 KFKELGIQPV PLQTITNENP SGPSLGTIPQ AHFLLVMLSM LTLQHSANNL DLLLNSGTLA 550 560 570 580 590 600 LAQTALRLIG PSCDSVEEDM NASAQGASAT VLEETRKETA PVQLPVSGPE LAAMMKIGTR 610 620 630 640 650 660 VMRGVDWKWG DQDRPPPGLG RVIGELGEDG WIRVQWDTGS TNSYRMGKEG NYDLKLAELP 670 680 690 700 710 720 APAQPSAEDS DTEDDSEAEQ TERNIHPTAM MFTSTINLLQ TLCLSAGVHA EIMQSEATKT 730 740 750 760 770 780 LCGLLQMLVY REQHRSWCTL GFVQSIALTL QVCGTLSSLQ WITLLMKVVE GHAPFTATSL 790 800 810 820 830 840 QRQILAVHLL QAVLPSWDKT ERARDMKCLM EKLFDFLGSL LTMCSSDVPL LRESTLRRRR 850 860 870 880 890 900 VCPQASLTAT HSSTLAEEVV ALLHTLHSLT QWNGLINKYI NSQLRSITHS FAGRPSKGAQ 910 920 930 940 950 960 LEDYFPDSEN PEVGGLMAVL AVVGGIDGRL CLGGQVVHDD FGEVTMTRIT LKGKITVQFS 970 980 990 1000 1010 1020 DMRTCHVCPL NQLKPLPAVA FNVNNLPFTE PMLSVWAQLV NLAGSKLEKH KIKKSTKQAF 1030 1040 1050 1060 1070 1080 AGQVDLDLLR CQQLKLYILK AGRALFSHQD KLRQILSQPA VQETGTVHTD DGAVVSPDLG 1090 1100 1110 1120 1130 1140 DMSPEGPQPP MILLQQLLAS ATQPSPVKAI FDKQELEERM SRCCFWRRRT TKLEQILLFI 1150 RRMNSVCEKE NTNATASN

References

[1]

"Analysis of the DNA sequence and duplication history of human chromosome 15." Zody M.C., Garber M., Sharpe T., Young S.K., Rowen L., O'Neill K., Whittaker C.A., Kamal M., Chang J.L., Cuomo C.A., Dewar K., FitzGerald M.G., Kodira C.D., Madan A., Qin S., Yang X., Abbasi N., Abouelleil A. , Arachchi H.M., Baradarani L., Birditt B., Bloom S., Bloom T., Borowsky M.L., Burke J., Butler J., Cook A., DeArellano K., DeCaprio D., Dorris L. III, Dors M., Eichler E.E., Engels R., Fahey J., Fleetwood P., Friedman C., Gearin G., Hall J.L., Hensley G., Johnson E., Jones C., Kamat A., Kaur A., Locke D.P., Madan A., Munson G., Jaffe D.B., Lui A., Macdonald P., Mauceli E., Naylor J.W., Nesbitt R., Nicol R., O'Leary S.B., Ratcliffe A., Rounsley S., She X., Sneddon K.M.B., Stewart S., Sougnez C., Stone S.M., Topham K., Vincent D., Wang S., Zimmer A.R., Birren B.W., Hood L., Lander E.S., Nusbaum C. Nature 440:671-675(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

[2]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Placenta and Testis.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AC026495 Genomic DNA. No translation available. BC000975 mRNA. No translation available. BC070076 mRNA. No translation available.
IPI	IPI00398607.
UniGene	Hs.608918.
3D structure databases
ProteinModelPortal	Q9BVR0.
ModBase	Search...
PTM databases
PhosphoSite	Q9BVR0.
Polymorphism databases
DMDM	205785731.
Proteomic databases
PRIDE	Q9BVR0.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
UCSC	uc001ytg.3. human.
Organism-specific databases
GeneCards	GC15M020589.
HGNC	HGNC:4871. HERC2P3.
HPA	CAB017188.
neXtProt	NX_Q9BVR0.
GenAtlas	Search...
Phylogenomic databases
HOVERGEN	HBG105898.
InParanoid	Q9BVR0.
Gene expression databases
Genevestigator	Q9BVR0.
Family and domain databases
InterPro	IPR010606. Mib_Herc2. [Graphical view]
Pfam	PF06701. MIB_HERC2. 1 hit. [Graphical view]
PROSITE	PS51416. MIB_HERC2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

HRC23_HUMAN

Accession

Primary (citable) accession number: Q9BVR0

Entry history

Integrated into UniProtKB/Swiss-Prot:	September 2, 2008
Last sequence update:	September 2, 2008
Last modified:	May 1, 2013
This is version 60 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.