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Q9BVR0

- HRC23_HUMAN

UniProt

Q9BVR0 - HRC23_HUMAN

Protein

Putative HERC2-like protein 3

Gene

HERC2P3

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 2 out of 5- Protein uncertaini
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    • History
      Entry version 66 (01 Oct 2014)
      Sequence version 2 (02 Sep 2008)
      Previous versions | rss
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    Functioni

    GO - Molecular functioni

    1. metal ion binding Source: InterPro
    2. ubiquitin-protein transferase activity Source: InterPro

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Putative HERC2-like protein 3
    Gene namesi
    Name:HERC2P3
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Unplaced

    Organism-specific databases

    HGNCiHGNC:4871. HERC2P3.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 11581158Putative HERC2-like protein 3PRO_0000349290Add
    BLAST

    Proteomic databases

    MaxQBiQ9BVR0.
    PRIDEiQ9BVR0.

    PTM databases

    PhosphoSiteiQ9BVR0.

    Expressioni

    Gene expression databases

    GenevestigatoriQ9BVR0.

    Organism-specific databases

    HPAiCAB017188.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9BVR0.
    SMRiQ9BVR0. Positions 595-657.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini587 – 66074MIB/HERC2PROSITE-ProRule annotationAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi837 – 8404Poly-Arg

    Sequence similaritiesi

    Contains 1 MIB/HERC2 domain.PROSITE-ProRule annotation

    Phylogenomic databases

    HOVERGENiHBG105898.
    InParanoidiQ9BVR0.

    Family and domain databases

    InterProiIPR010606. Mib_Herc2.
    [Graphical view]
    PfamiPF06701. MIB_HERC2. 1 hit.
    [Graphical view]
    PROSITEiPS51416. MIB_HERC2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9BVR0-1 [UniParc]FASTAAdd to Basket

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    MHAFCVGQYL EPDQEGVTIP DLGSLSSPLI DTERNLGLLL GLHASYLAMS     50
    TPLSPVEIEC AKWLQSSIFS GGLQTSQIHY SYNEEKDEDH CSSPGGTPAS 100
    KSRLCSHRRA LGDHSQAFLQ AIADNNIQDH NVKDFLCQIE RYCRQCHLTT 150
    PIMFPPEHPV EEVGRLLLCC LLKHEDLGHV ALSLVHAGAL GIEQVKHRTL 200
    PKSVVDVCRV VYQAKCSLIK THQEQGRSYK EVCAPVIERL RFLFNELRPA 250
    VCNDLSIMSK FKLLSSLPHW RRIAQKIIRE PRKKRVPKKP ESTDDEEKIG 300
    NEESDLEEAC ILPHSPINVD KRPIAIKSPK DKWQPLLSTV TGVHKYKWLK 350
    QNVQGLYPQS PLLSTIAEFA LKEEPVDVEK RKCLLKQLER AEVRLEGIDT 400
    ILKLYLVSKN FLLPSVPYAM FCGWQRLIPE GIDIGEPLTD CLKDVDLIPP 450
    FNRMLLEVTF GKLYAWAVQN IRNVLVDASA KFKELGIQPV PLQTITNENP 500
    SGPSLGTIPQ AHFLLVMLSM LTLQHSANNL DLLLNSGTLA LAQTALRLIG 550
    PSCDSVEEDM NASAQGASAT VLEETRKETA PVQLPVSGPE LAAMMKIGTR 600
    VMRGVDWKWG DQDRPPPGLG RVIGELGEDG WIRVQWDTGS TNSYRMGKEG 650
    NYDLKLAELP APAQPSAEDS DTEDDSEAEQ TERNIHPTAM MFTSTINLLQ 700
    TLCLSAGVHA EIMQSEATKT LCGLLQMLVY REQHRSWCTL GFVQSIALTL 750
    QVCGTLSSLQ WITLLMKVVE GHAPFTATSL QRQILAVHLL QAVLPSWDKT 800
    ERARDMKCLM EKLFDFLGSL LTMCSSDVPL LRESTLRRRR VCPQASLTAT 850
    HSSTLAEEVV ALLHTLHSLT QWNGLINKYI NSQLRSITHS FAGRPSKGAQ 900
    LEDYFPDSEN PEVGGLMAVL AVVGGIDGRL CLGGQVVHDD FGEVTMTRIT 950
    LKGKITVQFS DMRTCHVCPL NQLKPLPAVA FNVNNLPFTE PMLSVWAQLV 1000
    NLAGSKLEKH KIKKSTKQAF AGQVDLDLLR CQQLKLYILK AGRALFSHQD 1050
    KLRQILSQPA VQETGTVHTD DGAVVSPDLG DMSPEGPQPP MILLQQLLAS 1100
    ATQPSPVKAI FDKQELEERM SRCCFWRRRT TKLEQILLFI RRMNSVCEKE 1150
    NTNATASN 1158
    Length:1,158
    Mass (Da):128,943
    Last modified:September 2, 2008 - v2
    Checksum:iA1F748BFC0E70C27
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti278 – 2781I → V in BC070076. (PubMed:15489334)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti759 – 7591L → P.
    Corresponds to variant rs17134681 [ dbSNP | Ensembl ].
    VAR_046344
    Natural varianti1119 – 11191R → I.
    Corresponds to variant rs4931826 [ dbSNP | Ensembl ].
    VAR_046345

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC026495 Genomic DNA. No translation available.
    BC000975 mRNA. No translation available.
    BC070076 mRNA. No translation available.
    UniGeneiHs.608918.

    Genome annotation databases

    UCSCiuc001ytg.3. human.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC026495 Genomic DNA. No translation available.
    BC000975 mRNA. No translation available.
    BC070076 mRNA. No translation available.
    UniGenei Hs.608918.

    3D structure databases

    ProteinModelPortali Q9BVR0.
    SMRi Q9BVR0. Positions 595-657.
    ModBasei Search...
    MobiDBi Search...

    PTM databases

    PhosphoSitei Q9BVR0.

    Proteomic databases

    MaxQBi Q9BVR0.
    PRIDEi Q9BVR0.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    UCSCi uc001ytg.3. human.

    Organism-specific databases

    GeneCardsi GC15M020589.
    HGNCi HGNC:4871. HERC2P3.
    HPAi CAB017188.
    neXtProti NX_Q9BVR0.
    GenAtlasi Search...

    Phylogenomic databases

    HOVERGENi HBG105898.
    InParanoidi Q9BVR0.

    Gene expression databases

    Genevestigatori Q9BVR0.

    Family and domain databases

    InterProi IPR010606. Mib_Herc2.
    [Graphical view ]
    Pfami PF06701. MIB_HERC2. 1 hit.
    [Graphical view ]
    PROSITEi PS51416. MIB_HERC2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Analysis of the DNA sequence and duplication history of human chromosome 15."
      Zody M.C., Garber M., Sharpe T., Young S.K., Rowen L., O'Neill K., Whittaker C.A., Kamal M., Chang J.L., Cuomo C.A., Dewar K., FitzGerald M.G., Kodira C.D., Madan A., Qin S., Yang X., Abbasi N., Abouelleil A.
      , Arachchi H.M., Baradarani L., Birditt B., Bloom S., Bloom T., Borowsky M.L., Burke J., Butler J., Cook A., DeArellano K., DeCaprio D., Dorris L. III, Dors M., Eichler E.E., Engels R., Fahey J., Fleetwood P., Friedman C., Gearin G., Hall J.L., Hensley G., Johnson E., Jones C., Kamat A., Kaur A., Locke D.P., Madan A., Munson G., Jaffe D.B., Lui A., Macdonald P., Mauceli E., Naylor J.W., Nesbitt R., Nicol R., O'Leary S.B., Ratcliffe A., Rounsley S., She X., Sneddon K.M.B., Stewart S., Sougnez C., Stone S.M., Topham K., Vincent D., Wang S., Zimmer A.R., Birren B.W., Hood L., Lander E.S., Nusbaum C.
      Nature 440:671-675(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Placenta and Testis.

    Entry informationi

    Entry nameiHRC23_HUMAN
    AccessioniPrimary (citable) accession number: Q9BVR0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 2, 2008
    Last sequence update: September 2, 2008
    Last modified: October 1, 2014
    This is version 66 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Caution

    Could be the product of a pseudogene.Curated

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 15
      Human chromosome 15: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3