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Q9BVQ7

- SPA5L_HUMAN

UniProt

Q9BVQ7 - SPA5L_HUMAN

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Protein

Spermatogenesis-associated protein 5-like protein 1

Gene

SPATA5L1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli

Functioni

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi241 – 2488ATP 1Sequence Analysis
Nucleotide bindingi505 – 5128ATP 2Sequence Analysis

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
Complete GO annotation...

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Spermatogenesis-associated protein 5-like protein 1
Gene namesi
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 15

Organism-specific databases

HGNCiHGNC:28762. SPATA5L1.

Subcellular locationi

Cytoplasm Curated

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134923477.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 753753Spermatogenesis-associated protein 5-like protein 1PRO_0000330586Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei1 – 11N-acetylmethionine1 Publication

Keywords - PTMi

Acetylation

Proteomic databases

MaxQBiQ9BVQ7.
PaxDbiQ9BVQ7.
PRIDEiQ9BVQ7.

PTM databases

PhosphoSiteiQ9BVQ7.

Expressioni

Gene expression databases

BgeeiQ9BVQ7.
CleanExiHS_SPATA5L1.
GenevestigatoriQ9BVQ7.

Organism-specific databases

HPAiHPA043679.

Interactioni

Protein-protein interaction databases

BioGridi122496. 9 interactions.
IntActiQ9BVQ7. 1 interaction.
MINTiMINT-4718214.
STRINGi9606.ENSP00000305494.

Structurei

3D structure databases

ProteinModelPortaliQ9BVQ7.
SMRiQ9BVQ7. Positions 103-739.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the AAA ATPase family. AFG2 subfamily.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiCOG0464.
GeneTreeiENSGT00740000115527.
HOGENOMiHOG000223225.
HOVERGENiHBG001226.
InParanoidiQ9BVQ7.
OMAiTWEQIGG.
OrthoDBiEOG76MK7W.
PhylomeDBiQ9BVQ7.
TreeFamiTF325792.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
InterProiIPR003593. AAA+_ATPase.
IPR003959. ATPase_AAA_core.
IPR003960. ATPase_AAA_CS.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF00004. AAA. 2 hits.
[Graphical view]
SMARTiSM00382. AAA. 2 hits.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 2 hits.
PROSITEiPS00674. AAA. 2 hits.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q9BVQ7-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAPDSDPFPE GPLLKLLPLD ARDRGTQRCR LGPAALHALG ARLGSAVKIS
60 70 80 90 100
LPDGGSCLCT AWPRRDGADG FVQLDPLCAS PGAAVGASRS RRSLSLNRLL
110 120 130 140 150
LVPCPPLRRV AVWPVLRERA GAPGARNTAA VLEAAQELLR NRPISLGHVV
160 170 180 190 200
VAPPGAPGLV AALHIVGGTP SPDPAGLVTP RTRVSLGGEP PSEAQPQPEV
210 220 230 240 250
PLGGLSEAAD SLRELLRLPL RYPRALTALG LAVPRGVLLA GPPGVGKTQL
260 270 280 290 300
VRAVAREAGA ELLAVSAPAL QGSRPGETEE NVRRVFQRAR ELASRGPSLL
310 320 330 340 350
FLDEMDALCP QRGSRAPESR VVAQVLTLLD GASGDREVVV VGATNRPDAL
360 370 380 390 400
DPALRRPGRF DREVVIGTPT LKQRKEILQV ITSKMPISSH VDLGLLAEMT
410 420 430 440 450
VGYVGADLTA LCREAAMHAL LHSEKNQDNP VIDEIDFLEA FKNIQPSSFR
460 470 480 490 500
SVIGLMDIKP VDWEEIGGLE DVKLKLKQSI EWPLKFPWEF VRMGLTQPKG
510 520 530 540 550
VLLYGPPGCA KTTLVRALAT SCHCSFVSVS GADLFSPFVG DSEKVLSQIF
560 570 580 590 600
RQARASTPAI LFLDEIDSIL GARSASKTGC DVQERVLSVL LNELDGVGLK
610 620 630 640 650
TIERRGSKSS QQEFQEVFNR SVMIIAATNR PDVLDTALLR PGRLDKIIYI
660 670 680 690 700
PPPDHKGRLS ILKVCTKTMP IGPDVSLENL AAETCFFSGA DLRNLCTEAA
710 720 730 740 750
LLALQENGLD ATTVKQEHFL KSLKTVKPSL SCKDLALYEN LFKKEGFSNV

EGI
Length:753
Mass (Da):80,710
Last modified:March 23, 2010 - v2
Checksum:iE92A4483681017ED
GO
Isoform 2 (identifier: Q9BVQ7-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     613-620: EFQEVFNR → GKYKELKK
     621-753: Missing.

Note: No experimental confirmation available.

Show »
Length:620
Mass (Da):66,111
Checksum:i011455E160505748
GO
Isoform 3 (identifier: Q9BVQ7-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     365-392: VIGTPTLKQRKEILQVITSKMPISSHVD → NGLGGFAHCRWNLGRFWRHLAAPEAFAS
     393-753: Missing.

Note: No experimental confirmation available.

Show »
Length:392
Mass (Da):41,138
Checksum:i3B4DD28E9A2BD720
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti257 – 2571E → G in BAB14017. (PubMed:14702039)Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti119 – 1191R → P.
Corresponds to variant rs1153850 [ dbSNP | Ensembl ].
VAR_048111
Natural varianti252 – 2521R → Q.2 Publications
Corresponds to variant rs7182723 [ dbSNP | Ensembl ].
VAR_059085
Natural varianti592 – 5921N → D.
Corresponds to variant rs16943025 [ dbSNP | Ensembl ].
VAR_048112

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei365 – 39228VIGTP…SSHVD → NGLGGFAHCRWNLGRFWRHL AAPEAFAS in isoform 3. 1 PublicationVSP_033050Add
BLAST
Alternative sequencei393 – 753361Missing in isoform 3. 1 PublicationVSP_033051Add
BLAST
Alternative sequencei613 – 6208EFQEVFNR → GKYKELKK in isoform 2. 1 PublicationVSP_033052
Alternative sequencei621 – 753133Missing in isoform 2. 1 PublicationVSP_033053Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK022348 mRNA. Translation: BAB14017.1.
AK023232 mRNA. Translation: BAB14482.1.
AK291457 mRNA. Translation: BAF84146.1.
AC025580 Genomic DNA. No translation available.
AC090527 Genomic DNA. No translation available.
BC000981 mRNA. Translation: AAH00981.1.
CCDSiCCDS10123.1. [Q9BVQ7-1]
RefSeqiNP_076968.2. NM_024063.2. [Q9BVQ7-1]
UniGeneiHs.369657.

Genome annotation databases

EnsembliENST00000305560; ENSP00000305494; ENSG00000171763. [Q9BVQ7-1]
ENST00000531970; ENSP00000436823; ENSG00000171763. [Q9BVQ7-2]
GeneIDi79029.
KEGGihsa:79029.
UCSCiuc001zve.3. human. [Q9BVQ7-1]

Polymorphism databases

DMDMi292495038.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK022348 mRNA. Translation: BAB14017.1 .
AK023232 mRNA. Translation: BAB14482.1 .
AK291457 mRNA. Translation: BAF84146.1 .
AC025580 Genomic DNA. No translation available.
AC090527 Genomic DNA. No translation available.
BC000981 mRNA. Translation: AAH00981.1 .
CCDSi CCDS10123.1. [Q9BVQ7-1 ]
RefSeqi NP_076968.2. NM_024063.2. [Q9BVQ7-1 ]
UniGenei Hs.369657.

3D structure databases

ProteinModelPortali Q9BVQ7.
SMRi Q9BVQ7. Positions 103-739.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 122496. 9 interactions.
IntActi Q9BVQ7. 1 interaction.
MINTi MINT-4718214.
STRINGi 9606.ENSP00000305494.

PTM databases

PhosphoSitei Q9BVQ7.

Polymorphism databases

DMDMi 292495038.

Proteomic databases

MaxQBi Q9BVQ7.
PaxDbi Q9BVQ7.
PRIDEi Q9BVQ7.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000305560 ; ENSP00000305494 ; ENSG00000171763 . [Q9BVQ7-1 ]
ENST00000531970 ; ENSP00000436823 ; ENSG00000171763 . [Q9BVQ7-2 ]
GeneIDi 79029.
KEGGi hsa:79029.
UCSCi uc001zve.3. human. [Q9BVQ7-1 ]

Organism-specific databases

CTDi 79029.
GeneCardsi GC15P045694.
H-InvDB HIX0012209.
HGNCi HGNC:28762. SPATA5L1.
HPAi HPA043679.
neXtProti NX_Q9BVQ7.
PharmGKBi PA134923477.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG0464.
GeneTreei ENSGT00740000115527.
HOGENOMi HOG000223225.
HOVERGENi HBG001226.
InParanoidi Q9BVQ7.
OMAi TWEQIGG.
OrthoDBi EOG76MK7W.
PhylomeDBi Q9BVQ7.
TreeFami TF325792.

Miscellaneous databases

GenomeRNAii 79029.
NextBioi 67739.
PROi Q9BVQ7.

Gene expression databases

Bgeei Q9BVQ7.
CleanExi HS_SPATA5L1.
Genevestigatori Q9BVQ7.

Family and domain databases

Gene3Di 3.40.50.300. 2 hits.
InterProi IPR003593. AAA+_ATPase.
IPR003959. ATPase_AAA_core.
IPR003960. ATPase_AAA_CS.
IPR027417. P-loop_NTPase.
[Graphical view ]
Pfami PF00004. AAA. 2 hits.
[Graphical view ]
SMARTi SM00382. AAA. 2 hits.
[Graphical view ]
SUPFAMi SSF52540. SSF52540. 2 hits.
PROSITEi PS00674. AAA. 2 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 3), VARIANT GLN-252.
    Tissue: Mammary gland.
  2. "Analysis of the DNA sequence and duplication history of human chromosome 15."
    Zody M.C., Garber M., Sharpe T., Young S.K., Rowen L., O'Neill K., Whittaker C.A., Kamal M., Chang J.L., Cuomo C.A., Dewar K., FitzGerald M.G., Kodira C.D., Madan A., Qin S., Yang X., Abbasi N., Abouelleil A.
    , Arachchi H.M., Baradarani L., Birditt B., Bloom S., Bloom T., Borowsky M.L., Burke J., Butler J., Cook A., DeArellano K., DeCaprio D., Dorris L. III, Dors M., Eichler E.E., Engels R., Fahey J., Fleetwood P., Friedman C., Gearin G., Hall J.L., Hensley G., Johnson E., Jones C., Kamat A., Kaur A., Locke D.P., Madan A., Munson G., Jaffe D.B., Lui A., Macdonald P., Mauceli E., Naylor J.W., Nesbitt R., Nicol R., O'Leary S.B., Ratcliffe A., Rounsley S., She X., Sneddon K.M.B., Stewart S., Sougnez C., Stone S.M., Topham K., Vincent D., Wang S., Zimmer A.R., Birren B.W., Hood L., Lander E.S., Nusbaum C.
    Nature 440:671-675(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT GLN-252.
    Tissue: Cervix.
  4. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  5. Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT MET-1, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiSPA5L_HUMAN
AccessioniPrimary (citable) accession number: Q9BVQ7
Secondary accession number(s): C9JHR5, Q9H8W7, Q9HA41
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 29, 2008
Last sequence update: March 23, 2010
Last modified: October 29, 2014
This is version 111 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 15
    Human chromosome 15: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3