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Protein

Spermatogenesis-associated protein 5-like protein 1

Gene

SPATA5L1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi241 – 248ATP 1Sequence analysis8
Nucleotide bindingi505 – 512ATP 2Sequence analysis8

GO - Molecular functioni

Complete GO annotation...

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Spermatogenesis-associated protein 5-like protein 1
Gene namesi
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 15

Organism-specific databases

HGNCiHGNC:28762. SPATA5L1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Organism-specific databases

DisGeNETi79029.
OpenTargetsiENSG00000171763.
PharmGKBiPA134923477.

Polymorphism and mutation databases

BioMutaiSPATA5L1.
DMDMi292495038.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003305861 – 753Spermatogenesis-associated protein 5-like protein 1Add BLAST753

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineCombined sources1

Keywords - PTMi

Acetylation

Proteomic databases

EPDiQ9BVQ7.
MaxQBiQ9BVQ7.
PaxDbiQ9BVQ7.
PeptideAtlasiQ9BVQ7.
PRIDEiQ9BVQ7.

PTM databases

iPTMnetiQ9BVQ7.
PhosphoSitePlusiQ9BVQ7.

Expressioni

Gene expression databases

BgeeiENSG00000171763.
CleanExiHS_SPATA5L1.
ExpressionAtlasiQ9BVQ7. baseline and differential.
GenevisibleiQ9BVQ7. HS.

Organism-specific databases

HPAiHPA043679.

Interactioni

Protein-protein interaction databases

BioGridi122496. 28 interactors.
IntActiQ9BVQ7. 12 interactors.
MINTiMINT-4718214.
STRINGi9606.ENSP00000305494.

Structurei

3D structure databases

ProteinModelPortaliQ9BVQ7.
SMRiQ9BVQ7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the AAA ATPase family. AFG2 subfamily.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG0730. Eukaryota.
COG0464. LUCA.
GeneTreeiENSGT00860000133780.
HOGENOMiHOG000223225.
HOVERGENiHBG001226.
InParanoidiQ9BVQ7.
OMAiKSDQHEF.
OrthoDBiEOG091G03VW.
PhylomeDBiQ9BVQ7.
TreeFamiTF325792.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
InterProiIPR003593. AAA+_ATPase.
IPR003959. ATPase_AAA_core.
IPR003960. ATPase_AAA_CS.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF00004. AAA. 2 hits.
[Graphical view]
SMARTiSM00382. AAA. 2 hits.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 2 hits.
PROSITEiPS00674. AAA. 2 hits.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9BVQ7-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAPDSDPFPE GPLLKLLPLD ARDRGTQRCR LGPAALHALG ARLGSAVKIS
60 70 80 90 100
LPDGGSCLCT AWPRRDGADG FVQLDPLCAS PGAAVGASRS RRSLSLNRLL
110 120 130 140 150
LVPCPPLRRV AVWPVLRERA GAPGARNTAA VLEAAQELLR NRPISLGHVV
160 170 180 190 200
VAPPGAPGLV AALHIVGGTP SPDPAGLVTP RTRVSLGGEP PSEAQPQPEV
210 220 230 240 250
PLGGLSEAAD SLRELLRLPL RYPRALTALG LAVPRGVLLA GPPGVGKTQL
260 270 280 290 300
VRAVAREAGA ELLAVSAPAL QGSRPGETEE NVRRVFQRAR ELASRGPSLL
310 320 330 340 350
FLDEMDALCP QRGSRAPESR VVAQVLTLLD GASGDREVVV VGATNRPDAL
360 370 380 390 400
DPALRRPGRF DREVVIGTPT LKQRKEILQV ITSKMPISSH VDLGLLAEMT
410 420 430 440 450
VGYVGADLTA LCREAAMHAL LHSEKNQDNP VIDEIDFLEA FKNIQPSSFR
460 470 480 490 500
SVIGLMDIKP VDWEEIGGLE DVKLKLKQSI EWPLKFPWEF VRMGLTQPKG
510 520 530 540 550
VLLYGPPGCA KTTLVRALAT SCHCSFVSVS GADLFSPFVG DSEKVLSQIF
560 570 580 590 600
RQARASTPAI LFLDEIDSIL GARSASKTGC DVQERVLSVL LNELDGVGLK
610 620 630 640 650
TIERRGSKSS QQEFQEVFNR SVMIIAATNR PDVLDTALLR PGRLDKIIYI
660 670 680 690 700
PPPDHKGRLS ILKVCTKTMP IGPDVSLENL AAETCFFSGA DLRNLCTEAA
710 720 730 740 750
LLALQENGLD ATTVKQEHFL KSLKTVKPSL SCKDLALYEN LFKKEGFSNV

EGI
Length:753
Mass (Da):80,710
Last modified:March 23, 2010 - v2
Checksum:iE92A4483681017ED
GO
Isoform 2 (identifier: Q9BVQ7-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     613-620: EFQEVFNR → GKYKELKK
     621-753: Missing.

Note: No experimental confirmation available.
Show »
Length:620
Mass (Da):66,111
Checksum:i011455E160505748
GO
Isoform 3 (identifier: Q9BVQ7-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     365-392: VIGTPTLKQRKEILQVITSKMPISSHVD → NGLGGFAHCRWNLGRFWRHLAAPEAFAS
     393-753: Missing.

Note: No experimental confirmation available.
Show »
Length:392
Mass (Da):41,138
Checksum:i3B4DD28E9A2BD720
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti257E → G in BAB14017 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_048111119R → P.Corresponds to variant rs1153850dbSNPEnsembl.1
Natural variantiVAR_059085252R → Q.2 PublicationsCorresponds to variant rs7182723dbSNPEnsembl.1
Natural variantiVAR_048112592N → D.Corresponds to variant rs16943025dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_033050365 – 392VIGTP…SSHVD → NGLGGFAHCRWNLGRFWRHL AAPEAFAS in isoform 3. 1 PublicationAdd BLAST28
Alternative sequenceiVSP_033051393 – 753Missing in isoform 3. 1 PublicationAdd BLAST361
Alternative sequenceiVSP_033052613 – 620EFQEVFNR → GKYKELKK in isoform 2. 1 Publication8
Alternative sequenceiVSP_033053621 – 753Missing in isoform 2. 1 PublicationAdd BLAST133

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK022348 mRNA. Translation: BAB14017.1.
AK023232 mRNA. Translation: BAB14482.1.
AK291457 mRNA. Translation: BAF84146.1.
AC025580 Genomic DNA. No translation available.
AC090527 Genomic DNA. No translation available.
BC000981 mRNA. Translation: AAH00981.1.
CCDSiCCDS10123.1. [Q9BVQ7-1]
CCDS81877.1. [Q9BVQ7-2]
RefSeqiNP_001310569.1. NM_001323640.1. [Q9BVQ7-2]
NP_076968.2. NM_024063.2. [Q9BVQ7-1]
UniGeneiHs.369657.

Genome annotation databases

EnsembliENST00000305560; ENSP00000305494; ENSG00000171763. [Q9BVQ7-1]
ENST00000531970; ENSP00000436823; ENSG00000171763. [Q9BVQ7-2]
GeneIDi79029.
KEGGihsa:79029.
UCSCiuc001zve.4. human. [Q9BVQ7-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK022348 mRNA. Translation: BAB14017.1.
AK023232 mRNA. Translation: BAB14482.1.
AK291457 mRNA. Translation: BAF84146.1.
AC025580 Genomic DNA. No translation available.
AC090527 Genomic DNA. No translation available.
BC000981 mRNA. Translation: AAH00981.1.
CCDSiCCDS10123.1. [Q9BVQ7-1]
CCDS81877.1. [Q9BVQ7-2]
RefSeqiNP_001310569.1. NM_001323640.1. [Q9BVQ7-2]
NP_076968.2. NM_024063.2. [Q9BVQ7-1]
UniGeneiHs.369657.

3D structure databases

ProteinModelPortaliQ9BVQ7.
SMRiQ9BVQ7.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi122496. 28 interactors.
IntActiQ9BVQ7. 12 interactors.
MINTiMINT-4718214.
STRINGi9606.ENSP00000305494.

PTM databases

iPTMnetiQ9BVQ7.
PhosphoSitePlusiQ9BVQ7.

Polymorphism and mutation databases

BioMutaiSPATA5L1.
DMDMi292495038.

Proteomic databases

EPDiQ9BVQ7.
MaxQBiQ9BVQ7.
PaxDbiQ9BVQ7.
PeptideAtlasiQ9BVQ7.
PRIDEiQ9BVQ7.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000305560; ENSP00000305494; ENSG00000171763. [Q9BVQ7-1]
ENST00000531970; ENSP00000436823; ENSG00000171763. [Q9BVQ7-2]
GeneIDi79029.
KEGGihsa:79029.
UCSCiuc001zve.4. human. [Q9BVQ7-1]

Organism-specific databases

CTDi79029.
DisGeNETi79029.
GeneCardsiSPATA5L1.
H-InvDBHIX0012209.
HGNCiHGNC:28762. SPATA5L1.
HPAiHPA043679.
neXtProtiNX_Q9BVQ7.
OpenTargetsiENSG00000171763.
PharmGKBiPA134923477.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0730. Eukaryota.
COG0464. LUCA.
GeneTreeiENSGT00860000133780.
HOGENOMiHOG000223225.
HOVERGENiHBG001226.
InParanoidiQ9BVQ7.
OMAiKSDQHEF.
OrthoDBiEOG091G03VW.
PhylomeDBiQ9BVQ7.
TreeFamiTF325792.

Miscellaneous databases

GenomeRNAii79029.
PROiQ9BVQ7.

Gene expression databases

BgeeiENSG00000171763.
CleanExiHS_SPATA5L1.
ExpressionAtlasiQ9BVQ7. baseline and differential.
GenevisibleiQ9BVQ7. HS.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
InterProiIPR003593. AAA+_ATPase.
IPR003959. ATPase_AAA_core.
IPR003960. ATPase_AAA_CS.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF00004. AAA. 2 hits.
[Graphical view]
SMARTiSM00382. AAA. 2 hits.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 2 hits.
PROSITEiPS00674. AAA. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSPA5L_HUMAN
AccessioniPrimary (citable) accession number: Q9BVQ7
Secondary accession number(s): C9JHR5, Q9H8W7, Q9HA41
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 29, 2008
Last sequence update: March 23, 2010
Last modified: November 30, 2016
This is version 131 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 15
    Human chromosome 15: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.