Q9BVQ7 (SPA5L_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Spermatogenesis-associated protein 5-like protein 1

Gene names

Name:

SPATA5L1

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	753 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Subcellular location	Cytoplasm Potential.
Sequence similarities	Belongs to the AAA ATPase family. AFG2 subfamily.

Ontologies

Keywords
Cellular component	Cytoplasm
Coding sequence diversity	Alternative splicing Polymorphism
Domain	Repeat
Ligand	ATP-binding Nucleotide-binding
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular_component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW nucleoside-triphosphatase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Alternative products

This entry describes 3 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q9BVQ7-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q9BVQ7-2)

The sequence of this isoform differs from the canonical sequence as follows:
     613-620: EFQEVFNR → GKYKELKK
     621-753: Missing.

Note: No experimental confirmation available.

Isoform 3 (identifier: Q9BVQ7-3)

The sequence of this isoform differs from the canonical sequence as follows:
     365-392: VIGTPTLKQRKEILQVITSKMPISSHVD → NGLGGFAHCRWNLGRFWRHLAAPEAFAS
     393-753: Missing.

Note: No experimental confirmation available.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 753	753	Spermatogenesis-associated protein 5-like protein 1		PRO_0000330586
Regions
	Nucleotide binding	241 – 248	8	ATP 1 Potential
	Nucleotide binding	505 – 512	8	ATP 2 Potential
Natural variations
	Alternative sequence	365 – 392	28	VIGTP…SSHVD → NGLGGFAHCRWNLGRFWRHL AAPEAFAS in isoform 3.		VSP_033050
	Alternative sequence	393 – 753	361	Missing in isoform 3.		VSP_033051
	Alternative sequence	613 – 620	8	EFQEVFNR → GKYKELKK in isoform 2.		VSP_033052
	Alternative sequence	621 – 753	133	Missing in isoform 2.		VSP_033053
	Natural variant	119	1	R → P. Corresponds to variant rs1153850 [ dbSNP | Ensembl ].		VAR_048111
	Natural variant	252	1	R → Q. Ref.1 Ref.3 Corresponds to variant rs7182723 [ dbSNP | Ensembl ].		VAR_059085
	Natural variant	592	1	N → D. Corresponds to variant rs16943025 [ dbSNP | Ensembl ].		VAR_048112
Experimental info
	Sequence conflict	257	1	E → G in BAB14017. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified March 23, 2010. Version 2. Checksum: E92A4483681017ED	FASTA	753	80,710
	10 20 30 40 50 60 MAPDSDPFPE GPLLKLLPLD ARDRGTQRCR LGPAALHALG ARLGSAVKIS LPDGGSCLCT 70 80 90 100 110 120 AWPRRDGADG FVQLDPLCAS PGAAVGASRS RRSLSLNRLL LVPCPPLRRV AVWPVLRERA 130 140 150 160 170 180 GAPGARNTAA VLEAAQELLR NRPISLGHVV VAPPGAPGLV AALHIVGGTP SPDPAGLVTP 190 200 210 220 230 240 RTRVSLGGEP PSEAQPQPEV PLGGLSEAAD SLRELLRLPL RYPRALTALG LAVPRGVLLA 250 260 270 280 290 300 GPPGVGKTQL VRAVAREAGA ELLAVSAPAL QGSRPGETEE NVRRVFQRAR ELASRGPSLL 310 320 330 340 350 360 FLDEMDALCP QRGSRAPESR VVAQVLTLLD GASGDREVVV VGATNRPDAL DPALRRPGRF 370 380 390 400 410 420 DREVVIGTPT LKQRKEILQV ITSKMPISSH VDLGLLAEMT VGYVGADLTA LCREAAMHAL 430 440 450 460 470 480 LHSEKNQDNP VIDEIDFLEA FKNIQPSSFR SVIGLMDIKP VDWEEIGGLE DVKLKLKQSI 490 500 510 520 530 540 EWPLKFPWEF VRMGLTQPKG VLLYGPPGCA KTTLVRALAT SCHCSFVSVS GADLFSPFVG 550 560 570 580 590 600 DSEKVLSQIF RQARASTPAI LFLDEIDSIL GARSASKTGC DVQERVLSVL LNELDGVGLK 610 620 630 640 650 660 TIERRGSKSS QQEFQEVFNR SVMIIAATNR PDVLDTALLR PGRLDKIIYI PPPDHKGRLS 670 680 690 700 710 720 ILKVCTKTMP IGPDVSLENL AAETCFFSGA DLRNLCTEAA LLALQENGLD ATTVKQEHFL 730 740 750 KSLKTVKPSL SCKDLALYEN LFKKEGFSNV EGI
	Isoform 2 [UniParc]. Checksum: 011455E160505748	FASTA	620	66,111
	10 20 30 40 50 60 MAPDSDPFPE GPLLKLLPLD ARDRGTQRCR LGPAALHALG ARLGSAVKIS LPDGGSCLCT 70 80 90 100 110 120 AWPRRDGADG FVQLDPLCAS PGAAVGASRS RRSLSLNRLL LVPCPPLRRV AVWPVLRERA 130 140 150 160 170 180 GAPGARNTAA VLEAAQELLR NRPISLGHVV VAPPGAPGLV AALHIVGGTP SPDPAGLVTP 190 200 210 220 230 240 RTRVSLGGEP PSEAQPQPEV PLGGLSEAAD SLRELLRLPL RYPRALTALG LAVPRGVLLA 250 260 270 280 290 300 GPPGVGKTQL VRAVAREAGA ELLAVSAPAL QGSRPGETEE NVRRVFQRAR ELASRGPSLL 310 320 330 340 350 360 FLDEMDALCP QRGSRAPESR VVAQVLTLLD GASGDREVVV VGATNRPDAL DPALRRPGRF 370 380 390 400 410 420 DREVVIGTPT LKQRKEILQV ITSKMPISSH VDLGLLAEMT VGYVGADLTA LCREAAMHAL 430 440 450 460 470 480 LHSEKNQDNP VIDEIDFLEA FKNIQPSSFR SVIGLMDIKP VDWEEIGGLE DVKLKLKQSI 490 500 510 520 530 540 EWPLKFPWEF VRMGLTQPKG VLLYGPPGCA KTTLVRALAT SCHCSFVSVS GADLFSPFVG 550 560 570 580 590 600 DSEKVLSQIF RQARASTPAI LFLDEIDSIL GARSASKTGC DVQERVLSVL LNELDGVGLK 610 620 TIERRGSKSS QQGKYKELKK
	Isoform 3 [UniParc]. Checksum: 3B4DD28E9A2BD720	FASTA	392	41,138
	10 20 30 40 50 60 MAPDSDPFPE GPLLKLLPLD ARDRGTQRCR LGPAALHALG ARLGSAVKIS LPDGGSCLCT 70 80 90 100 110 120 AWPRRDGADG FVQLDPLCAS PGAAVGASRS RRSLSLNRLL LVPCPPLRRV AVWPVLRERA 130 140 150 160 170 180 GAPGARNTAA VLEAAQELLR NRPISLGHVV VAPPGAPGLV AALHIVGGTP SPDPAGLVTP 190 200 210 220 230 240 RTRVSLGGEP PSEAQPQPEV PLGGLSEAAD SLRELLRLPL RYPRALTALG LAVPRGVLLA 250 260 270 280 290 300 GPPGVGKTQL VRAVAREAGA ELLAVSAPAL QGSRPGETEE NVRRVFQRAR ELASRGPSLL 310 320 330 340 350 360 FLDEMDALCP QRGSRAPESR VVAQVLTLLD GASGDREVVV VGATNRPDAL DPALRRPGRF 370 380 390 DREVNGLGGF AHCRWNLGRF WRHLAAPEAF AS

References

[1]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 3), VARIANT GLN-252. Tissue: Mammary gland.
[2]	"Analysis of the DNA sequence and duplication history of human chromosome 15." Zody M.C., Garber M., Sharpe T., Young S.K., Rowen L., O'Neill K., Whittaker C.A., Kamal M., Chang J.L., Cuomo C.A., Dewar K., FitzGerald M.G., Kodira C.D., Madan A., Qin S., Yang X., Abbasi N., Abouelleil A. , Arachchi H.M., Baradarani L., Birditt B., Bloom S., Bloom T., Borowsky M.L., Burke J., Butler J., Cook A., DeArellano K., DeCaprio D., Dorris L. III, Dors M., Eichler E.E., Engels R., Fahey J., Fleetwood P., Friedman C., Gearin G., Hall J.L., Hensley G., Johnson E., Jones C., Kamat A., Kaur A., Locke D.P., Madan A., Munson G., Jaffe D.B., Lui A., Macdonald P., Mauceli E., Naylor J.W., Nesbitt R., Nicol R., O'Leary S.B., Ratcliffe A., Rounsley S., She X., Sneddon K.M.B., Stewart S., Sougnez C., Stone S.M., Topham K., Vincent D., Wang S., Zimmer A.R., Birren B.W., Hood L., Lander E.S., Nusbaum C. Nature 440:671-675(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT GLN-252. Tissue: Cervix.
[4]	"Initial characterization of the human central proteome." Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J. BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AK022348 mRNA. Translation: BAB14017.1. AK023232 mRNA. Translation: BAB14482.1. AK291457 mRNA. Translation: BAF84146.1. AC025580 Genomic DNA. No translation available. AC090527 Genomic DNA. No translation available. BC000981 mRNA. Translation: AAH00981.1.
IPI	IPI00031608. IPI00386906. IPI00890778.
RefSeq	NP_076968.2. NM_024063.2.
UniGene	Hs.369657.
3D structure databases
HSSP	HSSP built from PDB template 1YPW based on UniProtKB Q01853.
ProteinModelPortal	Q9BVQ7.
SMR	Q9BVQ7. Positions 103-739.
ModBase	Search...
PTM databases
PhosphoSite	Q9BVQ7.
Polymorphism databases
DMDM	292495038.
Proteomic databases
PaxDb	Q9BVQ7.
PRIDE	Q9BVQ7.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000305560; ENSP00000305494; ENSG00000171763. ENST00000531970; ENSP00000436823; ENSG00000171763. ENST00000559860; ENSP00000453406; ENSG00000171763.
GeneID	79029.
KEGG	hsa:79029.
UCSC	uc001zve.3. human.
Organism-specific databases
CTD	79029.
GeneCards	GC15P045694.
H-InvDB	HIX0012209.
HGNC	HGNC:28762. SPATA5L1.
HPA	HPA043679.
neXtProt	NX_Q9BVQ7.
PharmGKB	PA134923477.
GenAtlas	Search...
Phylogenomic databases
eggNOG	COG0464.
HOGENOM	HOG000223225.
HOVERGEN	HBG001226.
InParanoid	Q9BVQ7.
OMA	TWEQIGG.
OrthoDB	EOG42RD70.
PhylomeDB	Q9BVQ7.
Gene expression databases
Bgee	Q9BVQ7.
CleanEx	HS_SPATA5L1.
Genevestigator	Q9BVQ7.
Family and domain databases
InterPro	IPR003593. AAA+_ATPase. IPR003959. ATPase_AAA_core. IPR003960. ATPase_AAA_CS. [Graphical view]
Pfam	PF00004. AAA. 2 hits. [Graphical view]
SMART	SM00382. AAA. 2 hits. [Graphical view]
PROSITE	PS00674. AAA. 2 hits. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	79029.
NextBio	67739.

Entry information

Entry name

SPA5L_HUMAN

Accession

Primary (citable) accession number: Q9BVQ7
Secondary accession number(s): C9JHR5, Q9H8W7, Q9HA41

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 29, 2008
Last sequence update:	March 23, 2010
Last modified:	May 1, 2013
This is version 97 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.