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Protein

Spermatogenesis-associated protein 5-like protein 1

Gene

SPATA5L1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi241 – 248ATP 1Sequence analysis8
Nucleotide bindingi505 – 512ATP 2Sequence analysis8

GO - Molecular functioni

Keywordsi

LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Spermatogenesis-associated protein 5-like protein 1
Gene namesi
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 15

Organism-specific databases

EuPathDBiHostDB:ENSG00000171763.17
HGNCiHGNC:28762 SPATA5L1
neXtProtiNX_Q9BVQ7

Subcellular locationi

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Organism-specific databases

DisGeNETi79029
OpenTargetsiENSG00000171763
PharmGKBiPA134923477

Polymorphism and mutation databases

BioMutaiSPATA5L1
DMDMi292495038

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003305861 – 753Spermatogenesis-associated protein 5-like protein 1Add BLAST753

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineCombined sources1

Keywords - PTMi

Acetylation

Proteomic databases

EPDiQ9BVQ7
MaxQBiQ9BVQ7
PaxDbiQ9BVQ7
PeptideAtlasiQ9BVQ7
PRIDEiQ9BVQ7

PTM databases

iPTMnetiQ9BVQ7
PhosphoSitePlusiQ9BVQ7

Expressioni

Gene expression databases

BgeeiENSG00000171763
CleanExiHS_SPATA5L1
ExpressionAtlasiQ9BVQ7 baseline and differential
GenevisibleiQ9BVQ7 HS

Organism-specific databases

HPAiHPA043679

Interactioni

Protein-protein interaction databases

BioGridi122496, 33 interactors
IntActiQ9BVQ7, 15 interactors
MINTiQ9BVQ7
STRINGi9606.ENSP00000305494

Structurei

3D structure databases

ProteinModelPortaliQ9BVQ7
SMRiQ9BVQ7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the AAA ATPase family. AFG2 subfamily.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG0730 Eukaryota
COG0464 LUCA
GeneTreeiENSGT00900000140994
HOGENOMiHOG000223225
HOVERGENiHBG001226
InParanoidiQ9BVQ7
OMAiIKPVDWE
OrthoDBiEOG091G03VW
PhylomeDBiQ9BVQ7
TreeFamiTF325792

Family and domain databases

InterProiView protein in InterPro
IPR003593 AAA+_ATPase
IPR003959 ATPase_AAA_core
IPR003960 ATPase_AAA_CS
IPR027417 P-loop_NTPase
PfamiView protein in Pfam
PF00004 AAA, 2 hits
SMARTiView protein in SMART
SM00382 AAA, 2 hits
SUPFAMiSSF52540 SSF52540, 2 hits
PROSITEiView protein in PROSITE
PS00674 AAA, 2 hits

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9BVQ7-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAPDSDPFPE GPLLKLLPLD ARDRGTQRCR LGPAALHALG ARLGSAVKIS
60 70 80 90 100
LPDGGSCLCT AWPRRDGADG FVQLDPLCAS PGAAVGASRS RRSLSLNRLL
110 120 130 140 150
LVPCPPLRRV AVWPVLRERA GAPGARNTAA VLEAAQELLR NRPISLGHVV
160 170 180 190 200
VAPPGAPGLV AALHIVGGTP SPDPAGLVTP RTRVSLGGEP PSEAQPQPEV
210 220 230 240 250
PLGGLSEAAD SLRELLRLPL RYPRALTALG LAVPRGVLLA GPPGVGKTQL
260 270 280 290 300
VRAVAREAGA ELLAVSAPAL QGSRPGETEE NVRRVFQRAR ELASRGPSLL
310 320 330 340 350
FLDEMDALCP QRGSRAPESR VVAQVLTLLD GASGDREVVV VGATNRPDAL
360 370 380 390 400
DPALRRPGRF DREVVIGTPT LKQRKEILQV ITSKMPISSH VDLGLLAEMT
410 420 430 440 450
VGYVGADLTA LCREAAMHAL LHSEKNQDNP VIDEIDFLEA FKNIQPSSFR
460 470 480 490 500
SVIGLMDIKP VDWEEIGGLE DVKLKLKQSI EWPLKFPWEF VRMGLTQPKG
510 520 530 540 550
VLLYGPPGCA KTTLVRALAT SCHCSFVSVS GADLFSPFVG DSEKVLSQIF
560 570 580 590 600
RQARASTPAI LFLDEIDSIL GARSASKTGC DVQERVLSVL LNELDGVGLK
610 620 630 640 650
TIERRGSKSS QQEFQEVFNR SVMIIAATNR PDVLDTALLR PGRLDKIIYI
660 670 680 690 700
PPPDHKGRLS ILKVCTKTMP IGPDVSLENL AAETCFFSGA DLRNLCTEAA
710 720 730 740 750
LLALQENGLD ATTVKQEHFL KSLKTVKPSL SCKDLALYEN LFKKEGFSNV

EGI
Length:753
Mass (Da):80,710
Last modified:March 23, 2010 - v2
Checksum:iE92A4483681017ED
GO
Isoform 2 (identifier: Q9BVQ7-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     613-620: EFQEVFNR → GKYKELKK
     621-753: Missing.

Note: No experimental confirmation available.
Show »
Length:620
Mass (Da):66,111
Checksum:i011455E160505748
GO
Isoform 3 (identifier: Q9BVQ7-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     365-392: VIGTPTLKQRKEILQVITSKMPISSHVD → NGLGGFAHCRWNLGRFWRHLAAPEAFAS
     393-753: Missing.

Note: No experimental confirmation available.
Show »
Length:392
Mass (Da):41,138
Checksum:i3B4DD28E9A2BD720
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti257E → G in BAB14017 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_048111119R → P. Corresponds to variant dbSNP:rs1153850Ensembl.1
Natural variantiVAR_059085252R → Q2 PublicationsCorresponds to variant dbSNP:rs7182723Ensembl.1
Natural variantiVAR_048112592N → D. Corresponds to variant dbSNP:rs16943025Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_033050365 – 392VIGTP…SSHVD → NGLGGFAHCRWNLGRFWRHL AAPEAFAS in isoform 3. 1 PublicationAdd BLAST28
Alternative sequenceiVSP_033051393 – 753Missing in isoform 3. 1 PublicationAdd BLAST361
Alternative sequenceiVSP_033052613 – 620EFQEVFNR → GKYKELKK in isoform 2. 1 Publication8
Alternative sequenceiVSP_033053621 – 753Missing in isoform 2. 1 PublicationAdd BLAST133

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK022348 mRNA Translation: BAB14017.1
AK023232 mRNA Translation: BAB14482.1
AK291457 mRNA Translation: BAF84146.1
AC025580 Genomic DNA No translation available.
AC090527 Genomic DNA No translation available.
BC000981 mRNA Translation: AAH00981.1
CCDSiCCDS10123.1 [Q9BVQ7-1]
CCDS81877.1 [Q9BVQ7-2]
RefSeqiNP_001310569.1, NM_001323640.1 [Q9BVQ7-2]
NP_076968.2, NM_024063.2 [Q9BVQ7-1]
UniGeneiHs.369657

Genome annotation databases

EnsembliENST00000305560; ENSP00000305494; ENSG00000171763 [Q9BVQ7-1]
ENST00000531970; ENSP00000436823; ENSG00000171763 [Q9BVQ7-2]
ENST00000638607; ENSP00000492775; ENSG00000171763 [Q9BVQ7-2]
GeneIDi79029
KEGGihsa:79029
UCSCiuc001zve.4 human [Q9BVQ7-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiSPA5L_HUMAN
AccessioniPrimary (citable) accession number: Q9BVQ7
Secondary accession number(s): C9JHR5, Q9H8W7, Q9HA41
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 29, 2008
Last sequence update: March 23, 2010
Last modified: May 23, 2018
This is version 141 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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