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Q9BVQ7

- SPA5L_HUMAN

UniProt

Q9BVQ7 - SPA5L_HUMAN

Protein

Spermatogenesis-associated protein 5-like protein 1

Gene

SPATA5L1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 110 (01 Oct 2014)
      Sequence version 2 (23 Mar 2010)
      Previous versions | rss
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    Functioni

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi241 – 2488ATP 1Sequence Analysis
    Nucleotide bindingi505 – 5128ATP 2Sequence Analysis

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. nucleoside-triphosphatase activity Source: InterPro

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Spermatogenesis-associated protein 5-like protein 1
    Gene namesi
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 15

    Organism-specific databases

    HGNCiHGNC:28762. SPATA5L1.

    Subcellular locationi

    Cytoplasm Curated

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA134923477.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 753753Spermatogenesis-associated protein 5-like protein 1PRO_0000330586Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei1 – 11N-acetylmethionine1 Publication

    Keywords - PTMi

    Acetylation

    Proteomic databases

    MaxQBiQ9BVQ7.
    PaxDbiQ9BVQ7.
    PRIDEiQ9BVQ7.

    PTM databases

    PhosphoSiteiQ9BVQ7.

    Expressioni

    Gene expression databases

    BgeeiQ9BVQ7.
    CleanExiHS_SPATA5L1.
    GenevestigatoriQ9BVQ7.

    Organism-specific databases

    HPAiHPA043679.

    Interactioni

    Protein-protein interaction databases

    BioGridi122496. 3 interactions.
    IntActiQ9BVQ7. 1 interaction.
    MINTiMINT-4718214.
    STRINGi9606.ENSP00000305494.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9BVQ7.
    SMRiQ9BVQ7. Positions 103-739.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the AAA ATPase family. AFG2 subfamily.Curated

    Keywords - Domaini

    Repeat

    Phylogenomic databases

    eggNOGiCOG0464.
    HOGENOMiHOG000223225.
    HOVERGENiHBG001226.
    InParanoidiQ9BVQ7.
    OMAiTWEQIGG.
    OrthoDBiEOG76MK7W.
    PhylomeDBiQ9BVQ7.
    TreeFamiTF325792.

    Family and domain databases

    Gene3Di3.40.50.300. 2 hits.
    InterProiIPR003593. AAA+_ATPase.
    IPR003959. ATPase_AAA_core.
    IPR003960. ATPase_AAA_CS.
    IPR027417. P-loop_NTPase.
    [Graphical view]
    PfamiPF00004. AAA. 2 hits.
    [Graphical view]
    SMARTiSM00382. AAA. 2 hits.
    [Graphical view]
    SUPFAMiSSF52540. SSF52540. 2 hits.
    PROSITEiPS00674. AAA. 2 hits.
    [Graphical view]

    Sequences (3)i

    Sequence statusi: Complete.

    This entry describes 3 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q9BVQ7-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MAPDSDPFPE GPLLKLLPLD ARDRGTQRCR LGPAALHALG ARLGSAVKIS    50
    LPDGGSCLCT AWPRRDGADG FVQLDPLCAS PGAAVGASRS RRSLSLNRLL 100
    LVPCPPLRRV AVWPVLRERA GAPGARNTAA VLEAAQELLR NRPISLGHVV 150
    VAPPGAPGLV AALHIVGGTP SPDPAGLVTP RTRVSLGGEP PSEAQPQPEV 200
    PLGGLSEAAD SLRELLRLPL RYPRALTALG LAVPRGVLLA GPPGVGKTQL 250
    VRAVAREAGA ELLAVSAPAL QGSRPGETEE NVRRVFQRAR ELASRGPSLL 300
    FLDEMDALCP QRGSRAPESR VVAQVLTLLD GASGDREVVV VGATNRPDAL 350
    DPALRRPGRF DREVVIGTPT LKQRKEILQV ITSKMPISSH VDLGLLAEMT 400
    VGYVGADLTA LCREAAMHAL LHSEKNQDNP VIDEIDFLEA FKNIQPSSFR 450
    SVIGLMDIKP VDWEEIGGLE DVKLKLKQSI EWPLKFPWEF VRMGLTQPKG 500
    VLLYGPPGCA KTTLVRALAT SCHCSFVSVS GADLFSPFVG DSEKVLSQIF 550
    RQARASTPAI LFLDEIDSIL GARSASKTGC DVQERVLSVL LNELDGVGLK 600
    TIERRGSKSS QQEFQEVFNR SVMIIAATNR PDVLDTALLR PGRLDKIIYI 650
    PPPDHKGRLS ILKVCTKTMP IGPDVSLENL AAETCFFSGA DLRNLCTEAA 700
    LLALQENGLD ATTVKQEHFL KSLKTVKPSL SCKDLALYEN LFKKEGFSNV 750
    EGI 753
    Length:753
    Mass (Da):80,710
    Last modified:March 23, 2010 - v2
    Checksum:iE92A4483681017ED
    GO
    Isoform 2 (identifier: Q9BVQ7-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         613-620: EFQEVFNR → GKYKELKK
         621-753: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:620
    Mass (Da):66,111
    Checksum:i011455E160505748
    GO
    Isoform 3 (identifier: Q9BVQ7-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         365-392: VIGTPTLKQRKEILQVITSKMPISSHVD → NGLGGFAHCRWNLGRFWRHLAAPEAFAS
         393-753: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:392
    Mass (Da):41,138
    Checksum:i3B4DD28E9A2BD720
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti257 – 2571E → G in BAB14017. (PubMed:14702039)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti119 – 1191R → P.
    Corresponds to variant rs1153850 [ dbSNP | Ensembl ].
    VAR_048111
    Natural varianti252 – 2521R → Q.2 Publications
    Corresponds to variant rs7182723 [ dbSNP | Ensembl ].
    VAR_059085
    Natural varianti592 – 5921N → D.
    Corresponds to variant rs16943025 [ dbSNP | Ensembl ].
    VAR_048112

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei365 – 39228VIGTP…SSHVD → NGLGGFAHCRWNLGRFWRHL AAPEAFAS in isoform 3. 1 PublicationVSP_033050Add
    BLAST
    Alternative sequencei393 – 753361Missing in isoform 3. 1 PublicationVSP_033051Add
    BLAST
    Alternative sequencei613 – 6208EFQEVFNR → GKYKELKK in isoform 2. 1 PublicationVSP_033052
    Alternative sequencei621 – 753133Missing in isoform 2. 1 PublicationVSP_033053Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK022348 mRNA. Translation: BAB14017.1.
    AK023232 mRNA. Translation: BAB14482.1.
    AK291457 mRNA. Translation: BAF84146.1.
    AC025580 Genomic DNA. No translation available.
    AC090527 Genomic DNA. No translation available.
    BC000981 mRNA. Translation: AAH00981.1.
    CCDSiCCDS10123.1. [Q9BVQ7-1]
    RefSeqiNP_076968.2. NM_024063.2. [Q9BVQ7-1]
    UniGeneiHs.369657.

    Genome annotation databases

    EnsembliENST00000305560; ENSP00000305494; ENSG00000171763. [Q9BVQ7-1]
    ENST00000531970; ENSP00000436823; ENSG00000171763. [Q9BVQ7-2]
    GeneIDi79029.
    KEGGihsa:79029.
    UCSCiuc001zve.3. human. [Q9BVQ7-1]

    Polymorphism databases

    DMDMi292495038.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK022348 mRNA. Translation: BAB14017.1 .
    AK023232 mRNA. Translation: BAB14482.1 .
    AK291457 mRNA. Translation: BAF84146.1 .
    AC025580 Genomic DNA. No translation available.
    AC090527 Genomic DNA. No translation available.
    BC000981 mRNA. Translation: AAH00981.1 .
    CCDSi CCDS10123.1. [Q9BVQ7-1 ]
    RefSeqi NP_076968.2. NM_024063.2. [Q9BVQ7-1 ]
    UniGenei Hs.369657.

    3D structure databases

    ProteinModelPortali Q9BVQ7.
    SMRi Q9BVQ7. Positions 103-739.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 122496. 3 interactions.
    IntActi Q9BVQ7. 1 interaction.
    MINTi MINT-4718214.
    STRINGi 9606.ENSP00000305494.

    PTM databases

    PhosphoSitei Q9BVQ7.

    Polymorphism databases

    DMDMi 292495038.

    Proteomic databases

    MaxQBi Q9BVQ7.
    PaxDbi Q9BVQ7.
    PRIDEi Q9BVQ7.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000305560 ; ENSP00000305494 ; ENSG00000171763 . [Q9BVQ7-1 ]
    ENST00000531970 ; ENSP00000436823 ; ENSG00000171763 . [Q9BVQ7-2 ]
    GeneIDi 79029.
    KEGGi hsa:79029.
    UCSCi uc001zve.3. human. [Q9BVQ7-1 ]

    Organism-specific databases

    CTDi 79029.
    GeneCardsi GC15P045694.
    H-InvDB HIX0012209.
    HGNCi HGNC:28762. SPATA5L1.
    HPAi HPA043679.
    neXtProti NX_Q9BVQ7.
    PharmGKBi PA134923477.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG0464.
    HOGENOMi HOG000223225.
    HOVERGENi HBG001226.
    InParanoidi Q9BVQ7.
    OMAi TWEQIGG.
    OrthoDBi EOG76MK7W.
    PhylomeDBi Q9BVQ7.
    TreeFami TF325792.

    Miscellaneous databases

    GenomeRNAii 79029.
    NextBioi 67739.
    PROi Q9BVQ7.

    Gene expression databases

    Bgeei Q9BVQ7.
    CleanExi HS_SPATA5L1.
    Genevestigatori Q9BVQ7.

    Family and domain databases

    Gene3Di 3.40.50.300. 2 hits.
    InterProi IPR003593. AAA+_ATPase.
    IPR003959. ATPase_AAA_core.
    IPR003960. ATPase_AAA_CS.
    IPR027417. P-loop_NTPase.
    [Graphical view ]
    Pfami PF00004. AAA. 2 hits.
    [Graphical view ]
    SMARTi SM00382. AAA. 2 hits.
    [Graphical view ]
    SUPFAMi SSF52540. SSF52540. 2 hits.
    PROSITEi PS00674. AAA. 2 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 3), VARIANT GLN-252.
      Tissue: Mammary gland.
    2. "Analysis of the DNA sequence and duplication history of human chromosome 15."
      Zody M.C., Garber M., Sharpe T., Young S.K., Rowen L., O'Neill K., Whittaker C.A., Kamal M., Chang J.L., Cuomo C.A., Dewar K., FitzGerald M.G., Kodira C.D., Madan A., Qin S., Yang X., Abbasi N., Abouelleil A.
      , Arachchi H.M., Baradarani L., Birditt B., Bloom S., Bloom T., Borowsky M.L., Burke J., Butler J., Cook A., DeArellano K., DeCaprio D., Dorris L. III, Dors M., Eichler E.E., Engels R., Fahey J., Fleetwood P., Friedman C., Gearin G., Hall J.L., Hensley G., Johnson E., Jones C., Kamat A., Kaur A., Locke D.P., Madan A., Munson G., Jaffe D.B., Lui A., Macdonald P., Mauceli E., Naylor J.W., Nesbitt R., Nicol R., O'Leary S.B., Ratcliffe A., Rounsley S., She X., Sneddon K.M.B., Stewart S., Sougnez C., Stone S.M., Topham K., Vincent D., Wang S., Zimmer A.R., Birren B.W., Hood L., Lander E.S., Nusbaum C.
      Nature 440:671-675(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT GLN-252.
      Tissue: Cervix.
    4. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    5. Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT MET-1, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiSPA5L_HUMAN
    AccessioniPrimary (citable) accession number: Q9BVQ7
    Secondary accession number(s): C9JHR5, Q9H8W7, Q9HA41
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 29, 2008
    Last sequence update: March 23, 2010
    Last modified: October 1, 2014
    This is version 110 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 15
      Human chromosome 15: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3