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Q9BVQ7 (SPA5L_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 109. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (4) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Spermatogenesis-associated protein 5-like protein 1
Gene names
Name:SPATA5L1
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length753 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Subcellular location

Cytoplasm Potential.

Sequence similarities

Belongs to the AAA ATPase family. AFG2 subfamily.

Ontologies

Keywords
   Cellular componentCytoplasm
   Coding sequence diversityAlternative splicing
Polymorphism
   DomainRepeat
   LigandATP-binding
Nucleotide-binding
   PTMAcetylation
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-KW

nucleoside-triphosphatase activity

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Alternative products

This entry describes 3 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q9BVQ7-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q9BVQ7-2)

The sequence of this isoform differs from the canonical sequence as follows:
     613-620: EFQEVFNR → GKYKELKK
     621-753: Missing.
Note: No experimental confirmation available.
Isoform 3 (identifier: Q9BVQ7-3)

The sequence of this isoform differs from the canonical sequence as follows:
     365-392: VIGTPTLKQRKEILQVITSKMPISSHVD → NGLGGFAHCRWNLGRFWRHLAAPEAFAS
     393-753: Missing.
Note: No experimental confirmation available.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 753753Spermatogenesis-associated protein 5-like protein 1
PRO_0000330586

Regions

Nucleotide binding241 – 2488ATP 1 Potential
Nucleotide binding505 – 5128ATP 2 Potential

Amino acid modifications

Modified residue11N-acetylmethionine Ref.5

Natural variations

Alternative sequence365 – 39228VIGTP…SSHVD → NGLGGFAHCRWNLGRFWRHL AAPEAFAS in isoform 3.
VSP_033050
Alternative sequence393 – 753361Missing in isoform 3.
VSP_033051
Alternative sequence613 – 6208EFQEVFNR → GKYKELKK in isoform 2.
VSP_033052
Alternative sequence621 – 753133Missing in isoform 2.
VSP_033053
Natural variant1191R → P.
Corresponds to variant rs1153850 [ dbSNP | Ensembl ].
VAR_048111
Natural variant2521R → Q. Ref.1 Ref.3
Corresponds to variant rs7182723 [ dbSNP | Ensembl ].
VAR_059085
Natural variant5921N → D.
Corresponds to variant rs16943025 [ dbSNP | Ensembl ].
VAR_048112

Experimental info

Sequence conflict2571E → G in BAB14017. Ref.1

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified March 23, 2010. Version 2.
Checksum: E92A4483681017ED

FASTA75380,710
        10         20         30         40         50         60 
MAPDSDPFPE GPLLKLLPLD ARDRGTQRCR LGPAALHALG ARLGSAVKIS LPDGGSCLCT 

        70         80         90        100        110        120 
AWPRRDGADG FVQLDPLCAS PGAAVGASRS RRSLSLNRLL LVPCPPLRRV AVWPVLRERA 

       130        140        150        160        170        180 
GAPGARNTAA VLEAAQELLR NRPISLGHVV VAPPGAPGLV AALHIVGGTP SPDPAGLVTP 

       190        200        210        220        230        240 
RTRVSLGGEP PSEAQPQPEV PLGGLSEAAD SLRELLRLPL RYPRALTALG LAVPRGVLLA 

       250        260        270        280        290        300 
GPPGVGKTQL VRAVAREAGA ELLAVSAPAL QGSRPGETEE NVRRVFQRAR ELASRGPSLL 

       310        320        330        340        350        360 
FLDEMDALCP QRGSRAPESR VVAQVLTLLD GASGDREVVV VGATNRPDAL DPALRRPGRF 

       370        380        390        400        410        420 
DREVVIGTPT LKQRKEILQV ITSKMPISSH VDLGLLAEMT VGYVGADLTA LCREAAMHAL 

       430        440        450        460        470        480 
LHSEKNQDNP VIDEIDFLEA FKNIQPSSFR SVIGLMDIKP VDWEEIGGLE DVKLKLKQSI 

       490        500        510        520        530        540 
EWPLKFPWEF VRMGLTQPKG VLLYGPPGCA KTTLVRALAT SCHCSFVSVS GADLFSPFVG 

       550        560        570        580        590        600 
DSEKVLSQIF RQARASTPAI LFLDEIDSIL GARSASKTGC DVQERVLSVL LNELDGVGLK 

       610        620        630        640        650        660 
TIERRGSKSS QQEFQEVFNR SVMIIAATNR PDVLDTALLR PGRLDKIIYI PPPDHKGRLS 

       670        680        690        700        710        720 
ILKVCTKTMP IGPDVSLENL AAETCFFSGA DLRNLCTEAA LLALQENGLD ATTVKQEHFL 

       730        740        750 
KSLKTVKPSL SCKDLALYEN LFKKEGFSNV EGI 

« Hide

Isoform 2 [UniParc].

Checksum: 011455E160505748
Show »

FASTA62066,111
Isoform 3 [UniParc].

Checksum: 3B4DD28E9A2BD720
Show »

FASTA39241,138

References

[1]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 3), VARIANT GLN-252.
Tissue: Mammary gland.
[2]"Analysis of the DNA sequence and duplication history of human chromosome 15."
Zody M.C., Garber M., Sharpe T., Young S.K., Rowen L., O'Neill K., Whittaker C.A., Kamal M., Chang J.L., Cuomo C.A., Dewar K., FitzGerald M.G., Kodira C.D., Madan A., Qin S., Yang X., Abbasi N., Abouelleil A. expand/collapse author list , Arachchi H.M., Baradarani L., Birditt B., Bloom S., Bloom T., Borowsky M.L., Burke J., Butler J., Cook A., DeArellano K., DeCaprio D., Dorris L. III, Dors M., Eichler E.E., Engels R., Fahey J., Fleetwood P., Friedman C., Gearin G., Hall J.L., Hensley G., Johnson E., Jones C., Kamat A., Kaur A., Locke D.P., Madan A., Munson G., Jaffe D.B., Lui A., Macdonald P., Mauceli E., Naylor J.W., Nesbitt R., Nicol R., O'Leary S.B., Ratcliffe A., Rounsley S., She X., Sneddon K.M.B., Stewart S., Sougnez C., Stone S.M., Topham K., Vincent D., Wang S., Zimmer A.R., Birren B.W., Hood L., Lander E.S., Nusbaum C.
Nature 440:671-675(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT GLN-252.
Tissue: Cervix.
[4]"Initial characterization of the human central proteome."
Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J.
BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[5]"N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB."
Van Damme P., Lasa M., Polevoda B., Gazquez C., Elosegui-Artola A., Kim D.S., De Juan-Pardo E., Demeyer K., Hole K., Larrea E., Timmerman E., Prieto J., Arnesen T., Sherman F., Gevaert K., Aldabe R.
Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012) [PubMed] [Europe PMC] [Abstract]
Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT MET-1, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AK022348 mRNA. Translation: BAB14017.1.
AK023232 mRNA. Translation: BAB14482.1.
AK291457 mRNA. Translation: BAF84146.1.
AC025580 Genomic DNA. No translation available.
AC090527 Genomic DNA. No translation available.
BC000981 mRNA. Translation: AAH00981.1.
CCDSCCDS10123.1. [Q9BVQ7-1]
RefSeqNP_076968.2. NM_024063.2. [Q9BVQ7-1]
UniGeneHs.369657.

3D structure databases

ProteinModelPortalQ9BVQ7.
SMRQ9BVQ7. Positions 103-739.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid122496. 3 interactions.
IntActQ9BVQ7. 1 interaction.
MINTMINT-4718214.
STRING9606.ENSP00000305494.

PTM databases

PhosphoSiteQ9BVQ7.

Polymorphism databases

DMDM292495038.

Proteomic databases

MaxQBQ9BVQ7.
PaxDbQ9BVQ7.
PRIDEQ9BVQ7.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000305560; ENSP00000305494; ENSG00000171763. [Q9BVQ7-1]
ENST00000531970; ENSP00000436823; ENSG00000171763. [Q9BVQ7-2]
ENST00000559860; ENSP00000453406; ENSG00000171763. [Q9BVQ7-2]
GeneID79029.
KEGGhsa:79029.
UCSCuc001zve.3. human. [Q9BVQ7-1]

Organism-specific databases

CTD79029.
GeneCardsGC15P045694.
H-InvDBHIX0012209.
HGNCHGNC:28762. SPATA5L1.
HPAHPA043679.
neXtProtNX_Q9BVQ7.
PharmGKBPA134923477.
GenAtlasSearch...

Phylogenomic databases

eggNOGCOG0464.
HOGENOMHOG000223225.
HOVERGENHBG001226.
InParanoidQ9BVQ7.
OMATWEQIGG.
OrthoDBEOG76MK7W.
PhylomeDBQ9BVQ7.
TreeFamTF325792.

Gene expression databases

BgeeQ9BVQ7.
CleanExHS_SPATA5L1.
GenevestigatorQ9BVQ7.

Family and domain databases

Gene3D3.40.50.300. 2 hits.
InterProIPR003593. AAA+_ATPase.
IPR003959. ATPase_AAA_core.
IPR003960. ATPase_AAA_CS.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamPF00004. AAA. 2 hits.
[Graphical view]
SMARTSM00382. AAA. 2 hits.
[Graphical view]
SUPFAMSSF52540. SSF52540. 2 hits.
PROSITEPS00674. AAA. 2 hits.
[Graphical view]
ProtoNetSearch...

Other

GenomeRNAi79029.
NextBio67739.
PROQ9BVQ7.

Entry information

Entry nameSPA5L_HUMAN
AccessionPrimary (citable) accession number: Q9BVQ7
Secondary accession number(s): C9JHR5, Q9H8W7, Q9HA41
Entry history
Integrated into UniProtKB/Swiss-Prot: April 29, 2008
Last sequence update: March 23, 2010
Last modified: July 9, 2014
This is version 109 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 15

Human chromosome 15: entries, gene names and cross-references to MIM