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Q9BVN2

- RUSC1_HUMAN

UniProt

Q9BVN2 - RUSC1_HUMAN

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Protein

RUN and SH3 domain-containing protein 1

Gene

RUSC1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Putative signaling adapter which may play a role in neuronal differentiation. May be involved in regulation of NGF-dependent neurite outgrowth. Proposed to play a role in neuronal vesicular trafficking, specifically involving pre-synaptic membrane proteins. Seems to be involved in signaling pathways that are regulated by the prolonged activation of MAPK. Can regulate the polyubiquitination of IKBKG and thus may be involved in regulation of the NF-kappa-B pathway.1 Publication

GO - Molecular functioni

  1. actin binding Source: UniProtKB
  2. SH3/SH2 adaptor activity Source: ProtInc

GO - Biological processi

  1. positive regulation of signal transduction Source: GOC
  2. protein polyubiquitination Source: UniProtKB
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
RUN and SH3 domain-containing protein 1
Alternative name(s):
New molecule containing SH3 at the carboxy-terminus
Short name:
Nesca
Gene namesi
Name:RUSC1
Synonyms:NESCA
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 1

Organism-specific databases

HGNCiHGNC:17153. RUSC1.

Subcellular locationi

Cytoplasm. Nucleus. Cytoplasmcytoskeleton By similarity. Cytoplasmic vesicle By similarity. Early endosome By similarity. Cell junctionsynapsepostsynaptic cell membranepostsynaptic density By similarity. Golgi apparatus By similarity
Note: Translocated to the nuclear envelope upon stimulation with NGF. Associated with membranes and microtubules (By similarity).By similarity

GO - Cellular componenti

  1. cell junction Source: UniProtKB-KW
  2. cytoplasm Source: HPA
  3. cytoplasmic vesicle Source: UniProtKB
  4. early endosome Source: UniProtKB
  5. Golgi apparatus Source: UniProtKB
  6. microtubule Source: UniProtKB-KW
  7. microtubule cytoskeleton Source: UniProtKB
  8. nucleus Source: UniProtKB-KW
  9. postsynaptic membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cell membrane, Cytoplasm, Cytoplasmic vesicle, Cytoskeleton, Endosome, Golgi apparatus, Membrane, Microtubule, Nucleus, Postsynaptic cell membrane, Synapse

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi531 – 5311L → A: Abrogates nuclear redistribution. 1 Publication

Organism-specific databases

PharmGKBiPA134947113.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 902902RUN and SH3 domain-containing protein 1PRO_0000097532Add
BLAST

Post-translational modificationi

Phosphorylated on serine residues following nuclear translocation.
Polyubiquitinated; polyubiquitination involves TRAF6.1 Publication

Keywords - PTMi

Phosphoprotein, Ubl conjugation

Proteomic databases

MaxQBiQ9BVN2.
PaxDbiQ9BVN2.
PRIDEiQ9BVN2.

PTM databases

PhosphoSiteiQ9BVN2.

Expressioni

Tissue specificityi

Predominantly expressed in brain.

Gene expression databases

BgeeiQ9BVN2.
CleanExiHS_RUSC1.
ExpressionAtlasiQ9BVN2. baseline and differential.
GenevestigatoriQ9BVN2.

Organism-specific databases

HPAiHPA028510.
HPA029922.
HPA029923.

Interactioni

Subunit structurei

Interacts with IKBKG and TRAF6. Interacts with F-actin, acetylated actin, TUBB3, STX1A, KIF5B and KLC1 (By similarity).By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
IKBKGQ9Y6K94EBI-6257338,EBI-81279
TRAF6Q9Y4K32EBI-6257338,EBI-359276

Protein-protein interaction databases

BioGridi117155. 4 interactions.
IntActiQ9BVN2. 9 interactions.
STRINGi9606.ENSP00000292253.

Structurei

Secondary structure

1
902
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi484 – 50219
Helixi508 – 5158
Turni517 – 5193
Helixi521 – 5299
Helixi531 – 54010
Beta strandi545 – 5495
Turni550 – 5523
Beta strandi553 – 5564
Helixi559 – 5668
Helixi574 – 58512
Helixi592 – 60615
Helixi609 – 6179
Helixi620 – 6267
Helixi632 – 6354
Turni639 – 6424
Helixi643 – 6519
Helixi652 – 6565

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4GIWX-ray2.00A/B477-666[»]
ProteinModelPortaliQ9BVN2.
SMRiQ9BVN2. Positions 848-901.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini522 – 666145RUNPROSITE-ProRule annotationAdd
BLAST
Domaini844 – 90259SH3PROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni470 – 605136Interaction with TRAF6Add
BLAST
Regioni606 – 67267Interaction with IKBKGAdd
BLAST

Domaini

The RUN domain is necessary for NGF induced nuclear redistribution.

Sequence similaritiesi

Contains 1 RUN domain.PROSITE-ProRule annotation
Contains 1 SH3 domain.PROSITE-ProRule annotation

Keywords - Domaini

SH3 domain

Phylogenomic databases

eggNOGiNOG47427.
GeneTreeiENSGT00530000063878.
HOGENOMiHOG000010280.
HOVERGENiHBG058522.
InParanoidiQ9BVN2.
OMAiWKTNTGI.
OrthoDBiEOG757CWF.
PhylomeDBiQ9BVN2.
TreeFamiTF332235.

Family and domain databases

InterProiIPR004012. Run.
IPR001452. SH3_domain.
[Graphical view]
PfamiPF02759. RUN. 1 hit.
PF14604. SH3_9. 1 hit.
[Graphical view]
SMARTiSM00593. RUN. 1 hit.
SM00326. SH3. 1 hit.
[Graphical view]
SUPFAMiSSF50044. SSF50044. 1 hit.
PROSITEiPS50826. RUN. 1 hit.
PS50002. SH3. 1 hit.
[Graphical view]

Sequences (4)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q9BVN2-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MLSPQRALLC NLNHIHLQHV SLGLHLSRRP ELQEGPLSTP PPPGDTGGKE
60 70 80 90 100
SRGPCSGTLV DANSNSPAVP CRCCQEHGPG LENRQDPSQE EEGAASPSDP
110 120 130 140 150
GCSSSLSSCS DLSPDESPVS VYLRDLPGDE DAHPQPSIIP LEQGSPLASA
160 170 180 190 200
GPGTCSPDSF CCSPDSCSGA SSSPDPGLDS NCNALTTCQD VPSPGLEEED
210 220 230 240 250
ERAEQDLPTS ELLEADDGKI DAGKTEPSWK INPIWKIDTE KTKAEWKTTE
260 270 280 290 300
NNNTGWKNNG NVNSSWKSEP EKFDSGWKTN TRITDSGSKT DAGKIDGGWR
310 320 330 340 350
SDVSEEPVPH RTITSFHELA QKRKRGPGLP LVPQAKKDRS DWLIVFSPDT
360 370 380 390 400
ELPPSGSPGG SSAPPREVTT FKELRSRSRA PAPPVPPRDP PVGWALVPPR
410 420 430 440 450
PPPPPVPPRR KKNRPGLQPI AEGQSEEGRA VSPAAGEEAP AAKEPGAQAG
460 470 480 490 500
LEVRSSWSFA GVPGAQRLWM AEAQSGTGQL QEQKKGLLIA VSVSVDKIIS
510 520 530 540 550
HFGAARNLVQ KAQLGDSRLS PDVGHLVLTT LCPALHALVA DGLKPFRKDL
560 570 580 590 600
ITGQRRSSPW SVVEASVKPG SSTRSLGTLY SQVSRLAPLS SSRSRFHAFI
610 620 630 640 650
LGLLNTKQLE LWFSSLQEDA GLLSLLYLPT GFFSLARGGC PSLSTELLLL
660 670 680 690 700
LQPLSVLTFH LDLLFEHHHH LPLGPPQAPA PPGPPPALQQ TMQAMLHFGG
710 720 730 740 750
RLAQSLRGTS KEAASDPSDS PNLPTPGSWW EQLTQASRVY ASGGTEGFPL
760 770 780 790 800
SRWAPGRHGT AAEEGAQERP LPTDEMAPGR GLWLGRLFGV PGGPAENENG
810 820 830 840 850
ALKSRRPSSW LPPTVSVLAL VKRGAPPEMP SPQELEASAP RMVQTHRAVR
860 870 880 890 900
ALCDHTAARP DQLSFRRGEV LRVITTVDED WLRCGRDGME GLVPVGYTSL

VL
Length:902
Mass (Da):96,444
Last modified:October 23, 2007 - v3
Checksum:i41DB65236E766A82
GO
Isoform 2 (identifier: Q9BVN2-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-469: Missing.

Show »
Length:433
Mass (Da):46,592
Checksum:i6A1D519CA4291A94
GO
Isoform 3 (identifier: Q9BVN2-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-452: MLSPQRALLC...KEPGAQAGLE → MPPTCSPGLR...ALQALAGQAG

Show »
Length:492
Mass (Da):52,751
Checksum:i8F398A6E086099DF
GO
Isoform 4 (identifier: Q9BVN2-4) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     621-726: Missing.

Note: No experimental confirmation available.

Show »
Length:796
Mass (Da):85,216
Checksum:iD5772D1B94B5ABC2
GO

Sequence cautioni

The sequence AAH52277.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.
The sequence BAG54191.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti36 – 361P → S in BC025680. (PubMed:15489334)Curated
Sequence conflicti539 – 5391V → L in BAA77507. (PubMed:10760598)Curated
Sequence conflicti770 – 7701P → T in BAA77507. (PubMed:10760598)Curated
Sequence conflicti788 – 7881F → L in CAB45702. (PubMed:17974005)Curated
Sequence conflicti793 – 7953GPA → APP in BAA77507. (PubMed:10760598)Curated
Sequence conflicti852 – 8521L → F in CAB45702. (PubMed:17974005)Curated
Sequence conflicti865 – 8651F → Y in CAB45702. (PubMed:17974005)Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti362 – 3621S → F.
Corresponds to variant rs12061020 [ dbSNP | Ensembl ].
VAR_036803
Natural varianti493 – 4931V → A.
Corresponds to variant rs35826120 [ dbSNP | Ensembl ].
VAR_051329

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 469469Missing in isoform 2. 5 PublicationsVSP_010855Add
BLAST
Alternative sequencei1 – 452452MLSPQ…QAGLE → MPPTCSPGLRRQDWAPGRCA GLHLPPRAPSSPALQALAGQ AG in isoform 3. 1 PublicationVSP_054052Add
BLAST
Alternative sequencei621 – 726106Missing in isoform 4. 1 PublicationVSP_054053Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB026894 mRNA. Translation: BAA77507.2.
AL080083 mRNA. Translation: CAB45702.1.
AK314559 mRNA. Translation: BAG37144.1.
AK074982 mRNA. Translation: BAG52045.1.
AK055451 mRNA. No translation available.
AK125378 mRNA. Translation: BAG54191.1. Different initiation.
BX640612 mRNA. Translation: CAE45718.1.
AL139410 Genomic DNA. No translation available.
CH471121 Genomic DNA. Translation: EAW53069.1.
CH471121 Genomic DNA. Translation: EAW53071.1.
CH471121 Genomic DNA. Translation: EAW53072.1.
BC001045 mRNA. Translation: AAH01045.1.
BC025680 mRNA. No translation available.
BC052277 mRNA. Translation: AAH52277.1. Different initiation.
CCDSiCCDS1112.1. [Q9BVN2-2]
CCDS41410.1. [Q9BVN2-1]
CCDS41411.1. [Q9BVN2-4]
CCDS41412.1. [Q9BVN2-3]
PIRiT12473.
RefSeqiNP_001098673.1. NM_001105203.1. [Q9BVN2-1]
NP_001098674.1. NM_001105204.1. [Q9BVN2-4]
NP_001098675.1. NM_001105205.1. [Q9BVN2-3]
NP_001265156.1. NM_001278227.1.
NP_001265157.1. NM_001278228.1.
NP_001265158.1. NM_001278229.1.
NP_001265159.1. NM_001278230.1. [Q9BVN2-2]
NP_055143.2. NM_014328.4. [Q9BVN2-2]
XP_006711320.1. XM_006711257.1. [Q9BVN2-2]
XP_006711321.1. XM_006711258.1. [Q9BVN2-2]
UniGeneiHs.226499.

Genome annotation databases

EnsembliENST00000292254; ENSP00000292254; ENSG00000160753. [Q9BVN2-2]
ENST00000368347; ENSP00000357331; ENSG00000160753. [Q9BVN2-3]
ENST00000368349; ENSP00000357333; ENSG00000160753. [Q9BVN2-2]
ENST00000368352; ENSP00000357336; ENSG00000160753. [Q9BVN2-1]
ENST00000368354; ENSP00000357338; ENSG00000160753. [Q9BVN2-4]
GeneIDi23623.
KEGGihsa:23623.
UCSCiuc001fkj.2. human. [Q9BVN2-1]
uc001fkp.3. human. [Q9BVN2-2]

Polymorphism databases

DMDMi160380712.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB026894 mRNA. Translation: BAA77507.2 .
AL080083 mRNA. Translation: CAB45702.1 .
AK314559 mRNA. Translation: BAG37144.1 .
AK074982 mRNA. Translation: BAG52045.1 .
AK055451 mRNA. No translation available.
AK125378 mRNA. Translation: BAG54191.1 . Different initiation.
BX640612 mRNA. Translation: CAE45718.1 .
AL139410 Genomic DNA. No translation available.
CH471121 Genomic DNA. Translation: EAW53069.1 .
CH471121 Genomic DNA. Translation: EAW53071.1 .
CH471121 Genomic DNA. Translation: EAW53072.1 .
BC001045 mRNA. Translation: AAH01045.1 .
BC025680 mRNA. No translation available.
BC052277 mRNA. Translation: AAH52277.1 . Different initiation.
CCDSi CCDS1112.1. [Q9BVN2-2 ]
CCDS41410.1. [Q9BVN2-1 ]
CCDS41411.1. [Q9BVN2-4 ]
CCDS41412.1. [Q9BVN2-3 ]
PIRi T12473.
RefSeqi NP_001098673.1. NM_001105203.1. [Q9BVN2-1 ]
NP_001098674.1. NM_001105204.1. [Q9BVN2-4 ]
NP_001098675.1. NM_001105205.1. [Q9BVN2-3 ]
NP_001265156.1. NM_001278227.1.
NP_001265157.1. NM_001278228.1.
NP_001265158.1. NM_001278229.1.
NP_001265159.1. NM_001278230.1. [Q9BVN2-2 ]
NP_055143.2. NM_014328.4. [Q9BVN2-2 ]
XP_006711320.1. XM_006711257.1. [Q9BVN2-2 ]
XP_006711321.1. XM_006711258.1. [Q9BVN2-2 ]
UniGenei Hs.226499.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
4GIW X-ray 2.00 A/B 477-666 [» ]
ProteinModelPortali Q9BVN2.
SMRi Q9BVN2. Positions 848-901.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 117155. 4 interactions.
IntActi Q9BVN2. 9 interactions.
STRINGi 9606.ENSP00000292253.

PTM databases

PhosphoSitei Q9BVN2.

Polymorphism databases

DMDMi 160380712.

Proteomic databases

MaxQBi Q9BVN2.
PaxDbi Q9BVN2.
PRIDEi Q9BVN2.

Protocols and materials databases

DNASUi 23623.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000292254 ; ENSP00000292254 ; ENSG00000160753 . [Q9BVN2-2 ]
ENST00000368347 ; ENSP00000357331 ; ENSG00000160753 . [Q9BVN2-3 ]
ENST00000368349 ; ENSP00000357333 ; ENSG00000160753 . [Q9BVN2-2 ]
ENST00000368352 ; ENSP00000357336 ; ENSG00000160753 . [Q9BVN2-1 ]
ENST00000368354 ; ENSP00000357338 ; ENSG00000160753 . [Q9BVN2-4 ]
GeneIDi 23623.
KEGGi hsa:23623.
UCSCi uc001fkj.2. human. [Q9BVN2-1 ]
uc001fkp.3. human. [Q9BVN2-2 ]

Organism-specific databases

CTDi 23623.
GeneCardsi GC01P155290.
H-InvDB HIX0116321.
HGNCi HGNC:17153. RUSC1.
HPAi HPA028510.
HPA029922.
HPA029923.
neXtProti NX_Q9BVN2.
PharmGKBi PA134947113.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG47427.
GeneTreei ENSGT00530000063878.
HOGENOMi HOG000010280.
HOVERGENi HBG058522.
InParanoidi Q9BVN2.
OMAi WKTNTGI.
OrthoDBi EOG757CWF.
PhylomeDBi Q9BVN2.
TreeFami TF332235.

Miscellaneous databases

GenomeRNAii 23623.
NextBioi 46368.
PROi Q9BVN2.

Gene expression databases

Bgeei Q9BVN2.
CleanExi HS_RUSC1.
ExpressionAtlasi Q9BVN2. baseline and differential.
Genevestigatori Q9BVN2.

Family and domain databases

InterProi IPR004012. Run.
IPR001452. SH3_domain.
[Graphical view ]
Pfami PF02759. RUN. 1 hit.
PF14604. SH3_9. 1 hit.
[Graphical view ]
SMARTi SM00593. RUN. 1 hit.
SM00326. SH3. 1 hit.
[Graphical view ]
SUPFAMi SSF50044. SSF50044. 1 hit.
PROSITEi PS50826. RUN. 1 hit.
PS50002. SH3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Molecular cloning and characterization of a novel human gene (NESCA) which encodes a putative adapter protein containing SH3."
    Matsuda S., Miyazaki K., Ichigotani Y., Kurata H., Takenouchi Y., Yamamoto T., Nimura Y., Irimura T., Nakatsugawa S., Hamaguchi M.
    Biochim. Biophys. Acta 1491:321-326(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 4).
  3. "Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries."
    Otsuki T., Ota T., Nishikawa T., Hayashi K., Suzuki Y., Yamamoto J., Wakamatsu A., Kimura K., Sakamoto K., Hatano N., Kawai Y., Ishii S., Saito K., Kojima S., Sugiyama T., Ono T., Okano K., Yoshikawa Y.
    , Aotsuka S., Sasaki N., Hattori A., Okumura K., Nagai K., Sugano S., Isogai T.
    DNA Res. 12:117-126(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Brain and Endometrium.
  5. "The DNA sequence and biological annotation of human chromosome 1."
    Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
    , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
    Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 2 AND 3).
    Tissue: Lung and Placenta.
  8. "Nesca, a novel adapter, translocates to the nuclear envelope and regulates neurotrophin-induced neurite outgrowth."
    MacDonald J.I.S., Kubu C.J., Meakin S.O.
    J. Cell Biol. 164:851-862(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: CHARACTERIZATION, MUTAGENESIS OF LEU-531.
  9. Cited for: FUNCTION, INTERACTION WITH IKBKG AND TRAF6, UBIQUITINATION.

Entry informationi

Entry nameiRUSC1_HUMAN
AccessioniPrimary (citable) accession number: Q9BVN2
Secondary accession number(s): B3KWM9
, Q5T9U9, Q5T9V0, Q5T9V1, Q5T9V2, Q9UPY4, Q9Y4T5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 19, 2004
Last sequence update: October 23, 2007
Last modified: October 29, 2014
This is version 115 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3