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Q9BVN2

- RUSC1_HUMAN

UniProt

Q9BVN2 - RUSC1_HUMAN

Protein

RUN and SH3 domain-containing protein 1

Gene

RUSC1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 114 (01 Oct 2014)
      Sequence version 3 (23 Oct 2007)
      Previous versions | rss
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    Functioni

    Putative signaling adapter which may play a role in neuronal differentiation. May be involved in regulation of NGF-dependent neurite outgrowth. Proposed to play a role in neuronal vesicular trafficking, specifically involving pre-synaptic membrane proteins. Seems to be involved in signaling pathways that are regulated by the prolonged activation of MAPK. Can regulate the polyubiquitination of IKBKG and thus may be involved in regulation of the NF-kappa-B pathway.1 Publication

    GO - Molecular functioni

    1. actin binding Source: UniProtKB
    2. protein binding Source: IntAct
    3. SH3/SH2 adaptor activity Source: ProtInc

    GO - Biological processi

    1. positive regulation of signal transduction Source: GOC
    2. protein polyubiquitination Source: UniProtKB

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    RUN and SH3 domain-containing protein 1
    Alternative name(s):
    New molecule containing SH3 at the carboxy-terminus
    Short name:
    Nesca
    Gene namesi
    Name:RUSC1
    Synonyms:NESCA
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 1

    Organism-specific databases

    HGNCiHGNC:17153. RUSC1.

    Subcellular locationi

    Cytoplasm. Nucleus. Cytoplasmcytoskeleton By similarity. Cytoplasmic vesicle By similarity. Early endosome By similarity. Cell junctionsynapsepostsynaptic cell membranepostsynaptic density By similarity. Golgi apparatus By similarity
    Note: Translocated to the nuclear envelope upon stimulation with NGF. Associated with membranes and microtubules By similarity.By similarity

    GO - Cellular componenti

    1. cell junction Source: UniProtKB-KW
    2. cytoplasm Source: HPA
    3. cytoplasmic membrane-bounded vesicle Source: UniProtKB-SubCell
    4. cytoplasmic vesicle Source: UniProtKB
    5. early endosome Source: UniProtKB
    6. Golgi apparatus Source: UniProtKB
    7. microtubule Source: UniProtKB-KW
    8. microtubule cytoskeleton Source: UniProtKB
    9. nucleus Source: UniProtKB-SubCell
    10. postsynaptic density Source: UniProtKB-SubCell
    11. postsynaptic membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Cell junction, Cell membrane, Cytoplasm, Cytoplasmic vesicle, Cytoskeleton, Endosome, Golgi apparatus, Membrane, Microtubule, Nucleus, Postsynaptic cell membrane, Synapse

    Pathology & Biotechi

    Mutagenesis

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Mutagenesisi531 – 5311L → A: Abrogates nuclear redistribution. 1 Publication

    Organism-specific databases

    PharmGKBiPA134947113.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 902902RUN and SH3 domain-containing protein 1PRO_0000097532Add
    BLAST

    Post-translational modificationi

    Phosphorylated on serine residues following nuclear translocation.
    Polyubiquitinated; polyubiquitination involves TRAF6.1 Publication

    Keywords - PTMi

    Phosphoprotein, Ubl conjugation

    Proteomic databases

    MaxQBiQ9BVN2.
    PaxDbiQ9BVN2.
    PRIDEiQ9BVN2.

    PTM databases

    PhosphoSiteiQ9BVN2.

    Expressioni

    Tissue specificityi

    Predominantly expressed in brain.

    Gene expression databases

    ArrayExpressiQ9BVN2.
    BgeeiQ9BVN2.
    CleanExiHS_RUSC1.
    GenevestigatoriQ9BVN2.

    Organism-specific databases

    HPAiHPA028510.
    HPA029922.
    HPA029923.

    Interactioni

    Subunit structurei

    Interacts with IKBKG and TRAF6. Interacts with F-actin, acetylated actin, TUBB3, STX1A, KIF5B and KLC1 By similarity.By similarity

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    IKBKGQ9Y6K94EBI-6257338,EBI-81279
    TRAF6Q9Y4K32EBI-6257338,EBI-359276

    Protein-protein interaction databases

    BioGridi117155. 4 interactions.
    IntActiQ9BVN2. 9 interactions.
    STRINGi9606.ENSP00000292253.

    Structurei

    Secondary structure

    1
    902
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Helixi484 – 50219
    Helixi508 – 5158
    Turni517 – 5193
    Helixi521 – 5299
    Helixi531 – 54010
    Beta strandi545 – 5495
    Turni550 – 5523
    Beta strandi553 – 5564
    Helixi559 – 5668
    Helixi574 – 58512
    Helixi592 – 60615
    Helixi609 – 6179
    Helixi620 – 6267
    Helixi632 – 6354
    Turni639 – 6424
    Helixi643 – 6519
    Helixi652 – 6565

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    4GIWX-ray2.00A/B477-666[»]
    ProteinModelPortaliQ9BVN2.
    SMRiQ9BVN2. Positions 483-666, 848-901.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini522 – 666145RUNPROSITE-ProRule annotationAdd
    BLAST
    Domaini844 – 90259SH3PROSITE-ProRule annotationAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni470 – 605136Interaction with TRAF6Add
    BLAST
    Regioni606 – 67267Interaction with IKBKGAdd
    BLAST

    Domaini

    The RUN domain is necessary for NGF induced nuclear redistribution.

    Sequence similaritiesi

    Contains 1 RUN domain.PROSITE-ProRule annotation
    Contains 1 SH3 domain.PROSITE-ProRule annotation

    Keywords - Domaini

    SH3 domain

    Phylogenomic databases

    eggNOGiNOG47427.
    HOGENOMiHOG000010280.
    HOVERGENiHBG058522.
    InParanoidiQ9BVN2.
    OMAiWKTNTGI.
    OrthoDBiEOG757CWF.
    PhylomeDBiQ9BVN2.
    TreeFamiTF332235.

    Family and domain databases

    InterProiIPR004012. Run.
    IPR001452. SH3_domain.
    [Graphical view]
    PfamiPF02759. RUN. 1 hit.
    PF14604. SH3_9. 1 hit.
    [Graphical view]
    SMARTiSM00593. RUN. 1 hit.
    SM00326. SH3. 1 hit.
    [Graphical view]
    SUPFAMiSSF50044. SSF50044. 1 hit.
    PROSITEiPS50826. RUN. 1 hit.
    PS50002. SH3. 1 hit.
    [Graphical view]

    Sequences (4)i

    Sequence statusi: Complete.

    This entry describes 4 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q9BVN2-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MLSPQRALLC NLNHIHLQHV SLGLHLSRRP ELQEGPLSTP PPPGDTGGKE    50
    SRGPCSGTLV DANSNSPAVP CRCCQEHGPG LENRQDPSQE EEGAASPSDP 100
    GCSSSLSSCS DLSPDESPVS VYLRDLPGDE DAHPQPSIIP LEQGSPLASA 150
    GPGTCSPDSF CCSPDSCSGA SSSPDPGLDS NCNALTTCQD VPSPGLEEED 200
    ERAEQDLPTS ELLEADDGKI DAGKTEPSWK INPIWKIDTE KTKAEWKTTE 250
    NNNTGWKNNG NVNSSWKSEP EKFDSGWKTN TRITDSGSKT DAGKIDGGWR 300
    SDVSEEPVPH RTITSFHELA QKRKRGPGLP LVPQAKKDRS DWLIVFSPDT 350
    ELPPSGSPGG SSAPPREVTT FKELRSRSRA PAPPVPPRDP PVGWALVPPR 400
    PPPPPVPPRR KKNRPGLQPI AEGQSEEGRA VSPAAGEEAP AAKEPGAQAG 450
    LEVRSSWSFA GVPGAQRLWM AEAQSGTGQL QEQKKGLLIA VSVSVDKIIS 500
    HFGAARNLVQ KAQLGDSRLS PDVGHLVLTT LCPALHALVA DGLKPFRKDL 550
    ITGQRRSSPW SVVEASVKPG SSTRSLGTLY SQVSRLAPLS SSRSRFHAFI 600
    LGLLNTKQLE LWFSSLQEDA GLLSLLYLPT GFFSLARGGC PSLSTELLLL 650
    LQPLSVLTFH LDLLFEHHHH LPLGPPQAPA PPGPPPALQQ TMQAMLHFGG 700
    RLAQSLRGTS KEAASDPSDS PNLPTPGSWW EQLTQASRVY ASGGTEGFPL 750
    SRWAPGRHGT AAEEGAQERP LPTDEMAPGR GLWLGRLFGV PGGPAENENG 800
    ALKSRRPSSW LPPTVSVLAL VKRGAPPEMP SPQELEASAP RMVQTHRAVR 850
    ALCDHTAARP DQLSFRRGEV LRVITTVDED WLRCGRDGME GLVPVGYTSL 900
    VL 902
    Length:902
    Mass (Da):96,444
    Last modified:October 23, 2007 - v3
    Checksum:i41DB65236E766A82
    GO
    Isoform 2 (identifier: Q9BVN2-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-469: Missing.

    Show »
    Length:433
    Mass (Da):46,592
    Checksum:i6A1D519CA4291A94
    GO
    Isoform 3 (identifier: Q9BVN2-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-452: MLSPQRALLC...KEPGAQAGLE → MPPTCSPGLR...ALQALAGQAG

    Show »
    Length:492
    Mass (Da):52,751
    Checksum:i8F398A6E086099DF
    GO
    Isoform 4 (identifier: Q9BVN2-4) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         621-726: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:796
    Mass (Da):85,216
    Checksum:iD5772D1B94B5ABC2
    GO

    Sequence cautioni

    The sequence AAH52277.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.
    The sequence BAG54191.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti36 – 361P → S in BC025680. (PubMed:15489334)Curated
    Sequence conflicti539 – 5391V → L in BAA77507. (PubMed:10760598)Curated
    Sequence conflicti770 – 7701P → T in BAA77507. (PubMed:10760598)Curated
    Sequence conflicti788 – 7881F → L in CAB45702. (PubMed:17974005)Curated
    Sequence conflicti793 – 7953GPA → APP in BAA77507. (PubMed:10760598)Curated
    Sequence conflicti852 – 8521L → F in CAB45702. (PubMed:17974005)Curated
    Sequence conflicti865 – 8651F → Y in CAB45702. (PubMed:17974005)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti362 – 3621S → F.
    Corresponds to variant rs12061020 [ dbSNP | Ensembl ].
    VAR_036803
    Natural varianti493 – 4931V → A.
    Corresponds to variant rs35826120 [ dbSNP | Ensembl ].
    VAR_051329

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 469469Missing in isoform 2. 5 PublicationsVSP_010855Add
    BLAST
    Alternative sequencei1 – 452452MLSPQ…QAGLE → MPPTCSPGLRRQDWAPGRCA GLHLPPRAPSSPALQALAGQ AG in isoform 3. 1 PublicationVSP_054052Add
    BLAST
    Alternative sequencei621 – 726106Missing in isoform 4. 1 PublicationVSP_054053Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB026894 mRNA. Translation: BAA77507.2.
    AL080083 mRNA. Translation: CAB45702.1.
    AK314559 mRNA. Translation: BAG37144.1.
    AK074982 mRNA. Translation: BAG52045.1.
    AK055451 mRNA. No translation available.
    AK125378 mRNA. Translation: BAG54191.1. Different initiation.
    BX640612 mRNA. Translation: CAE45718.1.
    AL139410 Genomic DNA. No translation available.
    CH471121 Genomic DNA. Translation: EAW53069.1.
    CH471121 Genomic DNA. Translation: EAW53071.1.
    CH471121 Genomic DNA. Translation: EAW53072.1.
    BC001045 mRNA. Translation: AAH01045.1.
    BC025680 mRNA. No translation available.
    BC052277 mRNA. Translation: AAH52277.1. Different initiation.
    CCDSiCCDS1112.1. [Q9BVN2-2]
    CCDS41410.1. [Q9BVN2-1]
    CCDS41411.1. [Q9BVN2-4]
    CCDS41412.1. [Q9BVN2-3]
    PIRiT12473.
    RefSeqiNP_001098673.1. NM_001105203.1. [Q9BVN2-1]
    NP_001098674.1. NM_001105204.1. [Q9BVN2-4]
    NP_001098675.1. NM_001105205.1. [Q9BVN2-3]
    NP_001265156.1. NM_001278227.1.
    NP_001265157.1. NM_001278228.1.
    NP_001265158.1. NM_001278229.1.
    NP_001265159.1. NM_001278230.1. [Q9BVN2-2]
    NP_055143.2. NM_014328.4. [Q9BVN2-2]
    XP_006711320.1. XM_006711257.1. [Q9BVN2-2]
    XP_006711321.1. XM_006711258.1. [Q9BVN2-2]
    UniGeneiHs.226499.

    Genome annotation databases

    EnsembliENST00000292254; ENSP00000292254; ENSG00000160753. [Q9BVN2-2]
    ENST00000368347; ENSP00000357331; ENSG00000160753. [Q9BVN2-3]
    ENST00000368349; ENSP00000357333; ENSG00000160753. [Q9BVN2-2]
    ENST00000368352; ENSP00000357336; ENSG00000160753. [Q9BVN2-1]
    ENST00000368354; ENSP00000357338; ENSG00000160753. [Q9BVN2-4]
    GeneIDi23623.
    KEGGihsa:23623.
    UCSCiuc001fkj.2. human. [Q9BVN2-1]
    uc001fkp.3. human. [Q9BVN2-2]

    Polymorphism databases

    DMDMi160380712.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB026894 mRNA. Translation: BAA77507.2 .
    AL080083 mRNA. Translation: CAB45702.1 .
    AK314559 mRNA. Translation: BAG37144.1 .
    AK074982 mRNA. Translation: BAG52045.1 .
    AK055451 mRNA. No translation available.
    AK125378 mRNA. Translation: BAG54191.1 . Different initiation.
    BX640612 mRNA. Translation: CAE45718.1 .
    AL139410 Genomic DNA. No translation available.
    CH471121 Genomic DNA. Translation: EAW53069.1 .
    CH471121 Genomic DNA. Translation: EAW53071.1 .
    CH471121 Genomic DNA. Translation: EAW53072.1 .
    BC001045 mRNA. Translation: AAH01045.1 .
    BC025680 mRNA. No translation available.
    BC052277 mRNA. Translation: AAH52277.1 . Different initiation.
    CCDSi CCDS1112.1. [Q9BVN2-2 ]
    CCDS41410.1. [Q9BVN2-1 ]
    CCDS41411.1. [Q9BVN2-4 ]
    CCDS41412.1. [Q9BVN2-3 ]
    PIRi T12473.
    RefSeqi NP_001098673.1. NM_001105203.1. [Q9BVN2-1 ]
    NP_001098674.1. NM_001105204.1. [Q9BVN2-4 ]
    NP_001098675.1. NM_001105205.1. [Q9BVN2-3 ]
    NP_001265156.1. NM_001278227.1.
    NP_001265157.1. NM_001278228.1.
    NP_001265158.1. NM_001278229.1.
    NP_001265159.1. NM_001278230.1. [Q9BVN2-2 ]
    NP_055143.2. NM_014328.4. [Q9BVN2-2 ]
    XP_006711320.1. XM_006711257.1. [Q9BVN2-2 ]
    XP_006711321.1. XM_006711258.1. [Q9BVN2-2 ]
    UniGenei Hs.226499.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    4GIW X-ray 2.00 A/B 477-666 [» ]
    ProteinModelPortali Q9BVN2.
    SMRi Q9BVN2. Positions 483-666, 848-901.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 117155. 4 interactions.
    IntActi Q9BVN2. 9 interactions.
    STRINGi 9606.ENSP00000292253.

    PTM databases

    PhosphoSitei Q9BVN2.

    Polymorphism databases

    DMDMi 160380712.

    Proteomic databases

    MaxQBi Q9BVN2.
    PaxDbi Q9BVN2.
    PRIDEi Q9BVN2.

    Protocols and materials databases

    DNASUi 23623.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000292254 ; ENSP00000292254 ; ENSG00000160753 . [Q9BVN2-2 ]
    ENST00000368347 ; ENSP00000357331 ; ENSG00000160753 . [Q9BVN2-3 ]
    ENST00000368349 ; ENSP00000357333 ; ENSG00000160753 . [Q9BVN2-2 ]
    ENST00000368352 ; ENSP00000357336 ; ENSG00000160753 . [Q9BVN2-1 ]
    ENST00000368354 ; ENSP00000357338 ; ENSG00000160753 . [Q9BVN2-4 ]
    GeneIDi 23623.
    KEGGi hsa:23623.
    UCSCi uc001fkj.2. human. [Q9BVN2-1 ]
    uc001fkp.3. human. [Q9BVN2-2 ]

    Organism-specific databases

    CTDi 23623.
    GeneCardsi GC01P155290.
    H-InvDB HIX0116321.
    HGNCi HGNC:17153. RUSC1.
    HPAi HPA028510.
    HPA029922.
    HPA029923.
    neXtProti NX_Q9BVN2.
    PharmGKBi PA134947113.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG47427.
    HOGENOMi HOG000010280.
    HOVERGENi HBG058522.
    InParanoidi Q9BVN2.
    OMAi WKTNTGI.
    OrthoDBi EOG757CWF.
    PhylomeDBi Q9BVN2.
    TreeFami TF332235.

    Miscellaneous databases

    GenomeRNAii 23623.
    NextBioi 46368.
    PROi Q9BVN2.

    Gene expression databases

    ArrayExpressi Q9BVN2.
    Bgeei Q9BVN2.
    CleanExi HS_RUSC1.
    Genevestigatori Q9BVN2.

    Family and domain databases

    InterProi IPR004012. Run.
    IPR001452. SH3_domain.
    [Graphical view ]
    Pfami PF02759. RUN. 1 hit.
    PF14604. SH3_9. 1 hit.
    [Graphical view ]
    SMARTi SM00593. RUN. 1 hit.
    SM00326. SH3. 1 hit.
    [Graphical view ]
    SUPFAMi SSF50044. SSF50044. 1 hit.
    PROSITEi PS50826. RUN. 1 hit.
    PS50002. SH3. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Molecular cloning and characterization of a novel human gene (NESCA) which encodes a putative adapter protein containing SH3."
      Matsuda S., Miyazaki K., Ichigotani Y., Kurata H., Takenouchi Y., Yamamoto T., Nimura Y., Irimura T., Nakatsugawa S., Hamaguchi M.
      Biochim. Biophys. Acta 1491:321-326(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
    2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 4).
    3. "Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries."
      Otsuki T., Ota T., Nishikawa T., Hayashi K., Suzuki Y., Yamamoto J., Wakamatsu A., Kimura K., Sakamoto K., Hatano N., Kawai Y., Ishii S., Saito K., Kojima S., Sugiyama T., Ono T., Okano K., Yoshikawa Y.
      , Aotsuka S., Sasaki N., Hattori A., Okumura K., Nagai K., Sugano S., Isogai T.
      DNA Res. 12:117-126(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
      Tissue: Brain and Endometrium.
    5. "The DNA sequence and biological annotation of human chromosome 1."
      Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
      , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
      Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 2 AND 3).
      Tissue: Lung and Placenta.
    8. "Nesca, a novel adapter, translocates to the nuclear envelope and regulates neurotrophin-induced neurite outgrowth."
      MacDonald J.I.S., Kubu C.J., Meakin S.O.
      J. Cell Biol. 164:851-862(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: CHARACTERIZATION, MUTAGENESIS OF LEU-531.
    9. Cited for: FUNCTION, INTERACTION WITH IKBKG AND TRAF6, UBIQUITINATION.

    Entry informationi

    Entry nameiRUSC1_HUMAN
    AccessioniPrimary (citable) accession number: Q9BVN2
    Secondary accession number(s): B3KWM9
    , Q5T9U9, Q5T9V0, Q5T9V1, Q5T9V2, Q9UPY4, Q9Y4T5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 19, 2004
    Last sequence update: October 23, 2007
    Last modified: October 1, 2014
    This is version 114 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. Human chromosome 1
      Human chromosome 1: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3