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Q9BVN2 (RUSC1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 109. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
RUN and SH3 domain-containing protein 1
Alternative name(s):
New molecule containing SH3 at the carboxy-terminus
Short name=Nesca
Gene names
Name:RUSC1
Synonyms:NESCA
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length902 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Putative signaling adapter which may play a role in neuronal differentiation. May be involved in regulation of NGF-dependent neurite outgrowth. Proposed to play a role in neuronal vesicular trafficking, specifically involving pre-synaptic membrane proteins. Seems to be involved in signaling pathways that are regulated by the prolonged activation of MAPK. Can regulate the polyubiquitination of IKBKG and thus may be involved in regulation of the NF-kappa-B pathway. Ref.9

Subunit structure

Interacts with IKBKG and TRAF6. Interacts with F-actin, acetylated actin, TUBB3, STX1A, KIF5B and KLC1 By similarity. Ref.9

Subcellular location

Cytoplasm. Nucleus. Cytoplasmcytoskeleton By similarity. Cytoplasmic vesicle By similarity. Early endosome By similarity. Cell junctionsynapsepostsynaptic cell membranepostsynaptic density By similarity. Golgi apparatus By similarity. Note: Translocated to the nuclear envelope upon stimulation with NGF. Associated with membranes and microtubules By similarity.

Tissue specificity

Predominantly expressed in brain.

Domain

The RUN domain is necessary for NGF induced nuclear redistribution.

Post-translational modification

Phosphorylated on serine residues following nuclear translocation.

Polyubiquitinated; polyubiquitination involves TRAF6.

Sequence similarities

Contains 1 RUN domain.

Contains 1 SH3 domain.

Sequence caution

The sequence AAH52277.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

The sequence BAG54191.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

Ontologies

Keywords
   Cellular componentCell junction
Cell membrane
Cytoplasm
Cytoplasmic vesicle
Cytoskeleton
Endosome
Golgi apparatus
Membrane
Microtubule
Nucleus
Postsynaptic cell membrane
Synapse
   Coding sequence diversityAlternative splicing
Polymorphism
   DomainSH3 domain
   PTMPhosphoprotein
Ubl conjugation
   Technical term3D-structure
Complete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processpositive regulation of signal transduction

Traceable author statement Ref.1. Source: GOC

protein polyubiquitination

Inferred from direct assay Ref.9. Source: UniProtKB

   Cellular_componentGolgi apparatus

Inferred from sequence or structural similarity. Source: UniProtKB

cell junction

Inferred from electronic annotation. Source: UniProtKB-KW

cytoplasm

Inferred from direct assay. Source: HPA

cytoplasmic membrane-bounded vesicle

Inferred from electronic annotation. Source: UniProtKB-SubCell

cytoplasmic vesicle

Inferred from sequence or structural similarity. Source: UniProtKB

early endosome

Inferred from sequence or structural similarity. Source: UniProtKB

microtubule

Inferred from electronic annotation. Source: UniProtKB-KW

microtubule cytoskeleton

Inferred from sequence or structural similarity. Source: UniProtKB

nucleus

Inferred from electronic annotation. Source: UniProtKB-SubCell

postsynaptic density

Inferred from electronic annotation. Source: UniProtKB-SubCell

postsynaptic membrane

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular_functionSH3/SH2 adaptor activity

Traceable author statement Ref.1. Source: ProtInc

actin binding

Inferred from sequence or structural similarity. Source: UniProtKB

Complete GO annotation...

Binary interactions

With

Entry

#Exp.

IntAct

Notes

IKBKGQ9Y6K94EBI-6257338,EBI-81279
TRAF6Q9Y4K32EBI-6257338,EBI-359276

Alternative products

This entry describes 4 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q9BVN2-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q9BVN2-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-469: Missing.
Isoform 3 (identifier: Q9BVN2-3)

The sequence of this isoform differs from the canonical sequence as follows:
     1-452: MLSPQRALLC...KEPGAQAGLE → MPPTCSPGLR...ALQALAGQAG
Isoform 4 (identifier: Q9BVN2-4)

The sequence of this isoform differs from the canonical sequence as follows:
     621-726: Missing.
Note: No experimental confirmation available.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 902902RUN and SH3 domain-containing protein 1
PRO_0000097532

Regions

Domain522 – 666145RUN
Domain844 – 90259SH3
Region470 – 605136Interaction with TRAF6
Region606 – 67267Interaction with IKBKG

Natural variations

Alternative sequence1 – 469469Missing in isoform 2.
VSP_010855
Alternative sequence1 – 452452MLSPQ…QAGLE → MPPTCSPGLRRQDWAPGRCA GLHLPPRAPSSPALQALAGQ AG in isoform 3.
VSP_054052
Alternative sequence621 – 726106Missing in isoform 4.
VSP_054053
Natural variant3621S → F.
Corresponds to variant rs12061020 [ dbSNP | Ensembl ].
VAR_036803
Natural variant4931V → A.
Corresponds to variant rs35826120 [ dbSNP | Ensembl ].
VAR_051329

Experimental info

Mutagenesis5311L → A: Abrogates nuclear redistribution. Ref.8
Sequence conflict361P → S in BC025680. Ref.7
Sequence conflict5391V → L in BAA77507. Ref.1
Sequence conflict7701P → T in BAA77507. Ref.1
Sequence conflict7881F → L in CAB45702. Ref.4
Sequence conflict793 – 7953GPA → APP in BAA77507. Ref.1
Sequence conflict8521L → F in CAB45702. Ref.4
Sequence conflict8651F → Y in CAB45702. Ref.4

Secondary structure

............................... 902
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified October 23, 2007. Version 3.
Checksum: 41DB65236E766A82

FASTA90296,444
        10         20         30         40         50         60 
MLSPQRALLC NLNHIHLQHV SLGLHLSRRP ELQEGPLSTP PPPGDTGGKE SRGPCSGTLV 

        70         80         90        100        110        120 
DANSNSPAVP CRCCQEHGPG LENRQDPSQE EEGAASPSDP GCSSSLSSCS DLSPDESPVS 

       130        140        150        160        170        180 
VYLRDLPGDE DAHPQPSIIP LEQGSPLASA GPGTCSPDSF CCSPDSCSGA SSSPDPGLDS 

       190        200        210        220        230        240 
NCNALTTCQD VPSPGLEEED ERAEQDLPTS ELLEADDGKI DAGKTEPSWK INPIWKIDTE 

       250        260        270        280        290        300 
KTKAEWKTTE NNNTGWKNNG NVNSSWKSEP EKFDSGWKTN TRITDSGSKT DAGKIDGGWR 

       310        320        330        340        350        360 
SDVSEEPVPH RTITSFHELA QKRKRGPGLP LVPQAKKDRS DWLIVFSPDT ELPPSGSPGG 

       370        380        390        400        410        420 
SSAPPREVTT FKELRSRSRA PAPPVPPRDP PVGWALVPPR PPPPPVPPRR KKNRPGLQPI 

       430        440        450        460        470        480 
AEGQSEEGRA VSPAAGEEAP AAKEPGAQAG LEVRSSWSFA GVPGAQRLWM AEAQSGTGQL 

       490        500        510        520        530        540 
QEQKKGLLIA VSVSVDKIIS HFGAARNLVQ KAQLGDSRLS PDVGHLVLTT LCPALHALVA 

       550        560        570        580        590        600 
DGLKPFRKDL ITGQRRSSPW SVVEASVKPG SSTRSLGTLY SQVSRLAPLS SSRSRFHAFI 

       610        620        630        640        650        660 
LGLLNTKQLE LWFSSLQEDA GLLSLLYLPT GFFSLARGGC PSLSTELLLL LQPLSVLTFH 

       670        680        690        700        710        720 
LDLLFEHHHH LPLGPPQAPA PPGPPPALQQ TMQAMLHFGG RLAQSLRGTS KEAASDPSDS 

       730        740        750        760        770        780 
PNLPTPGSWW EQLTQASRVY ASGGTEGFPL SRWAPGRHGT AAEEGAQERP LPTDEMAPGR 

       790        800        810        820        830        840 
GLWLGRLFGV PGGPAENENG ALKSRRPSSW LPPTVSVLAL VKRGAPPEMP SPQELEASAP 

       850        860        870        880        890        900 
RMVQTHRAVR ALCDHTAARP DQLSFRRGEV LRVITTVDED WLRCGRDGME GLVPVGYTSL 


VL 

« Hide

Isoform 2 [UniParc].

Checksum: 6A1D519CA4291A94
Show »

FASTA43346,592
Isoform 3 [UniParc].

Checksum: 8F398A6E086099DF
Show »

FASTA49252,751
Isoform 4 [UniParc].

Checksum: D5772D1B94B5ABC2
Show »

FASTA79685,216

References

« Hide 'large scale' references
[1]"Molecular cloning and characterization of a novel human gene (NESCA) which encodes a putative adapter protein containing SH3."
Matsuda S., Miyazaki K., Ichigotani Y., Kurata H., Takenouchi Y., Yamamoto T., Nimura Y., Irimura T., Nakatsugawa S., Hamaguchi M.
Biochim. Biophys. Acta 1491:321-326(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
[2]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 4).
[3]"Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries."
Otsuki T., Ota T., Nishikawa T., Hayashi K., Suzuki Y., Yamamoto J., Wakamatsu A., Kimura K., Sakamoto K., Hatano N., Kawai Y., Ishii S., Saito K., Kojima S., Sugiyama T., Ono T., Okano K., Yoshikawa Y. expand/collapse author list , Aotsuka S., Sasaki N., Hattori A., Okumura K., Nagai K., Sugano S., Isogai T.
DNA Res. 12:117-126(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
[4]"The full-ORF clone resource of the German cDNA consortium."
Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I.
BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
Tissue: Brain and Endometrium.
[5]"The DNA sequence and biological annotation of human chromosome 1."
Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K. expand/collapse author list , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[6]Mural R.J., Istrail S., Sutton G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[7]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 2 AND 3).
Tissue: Lung and Placenta.
[8]"Nesca, a novel adapter, translocates to the nuclear envelope and regulates neurotrophin-induced neurite outgrowth."
MacDonald J.I.S., Kubu C.J., Meakin S.O.
J. Cell Biol. 164:851-862(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: CHARACTERIZATION, MUTAGENESIS OF LEU-531.
[9]"NESCA: a new NEMO/IKKgamma and TRAF6 interacting protein."
Napolitano G., Mirra S., Monfregola J., Lavorgna A., Leonardi A., Ursini M.V.
J. Cell. Physiol. 220:410-417(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION, INTERACTION WITH IKBKG AND TRAF6, UBIQUITINATION.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AB026894 mRNA. Translation: BAA77507.2.
AL080083 mRNA. Translation: CAB45702.1.
AK314559 mRNA. Translation: BAG37144.1.
AK074982 mRNA. Translation: BAG52045.1.
AK055451 mRNA. No translation available.
AK125378 mRNA. Translation: BAG54191.1. Different initiation.
BX640612 mRNA. Translation: CAE45718.1.
AL139410 Genomic DNA. No translation available.
CH471121 Genomic DNA. Translation: EAW53069.1.
CH471121 Genomic DNA. Translation: EAW53071.1.
CH471121 Genomic DNA. Translation: EAW53072.1.
BC001045 mRNA. Translation: AAH01045.1.
BC025680 mRNA. No translation available.
BC052277 mRNA. Translation: AAH52277.1. Different initiation.
PIRT12473.
RefSeqNP_001098673.1. NM_001105203.1.
NP_001098675.1. NM_001105205.1.
NP_001265156.1. NM_001278227.1.
NP_001265157.1. NM_001278228.1.
NP_001265158.1. NM_001278229.1.
NP_001265159.1. NM_001278230.1.
NP_055143.2. NM_014328.4.
UniGeneHs.226499.

3D structure databases

PDBe
RCSB PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
4GIWX-ray2.00A/B477-666[»]
ProteinModelPortalQ9BVN2.
SMRQ9BVN2. Positions 483-666, 847-901.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid117155. 4 interactions.
IntActQ9BVN2. 9 interactions.
STRING9606.ENSP00000292253.

PTM databases

PhosphoSiteQ9BVN2.

Polymorphism databases

DMDM160380712.

Proteomic databases

PaxDbQ9BVN2.
PRIDEQ9BVN2.

Protocols and materials databases

DNASU23623.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000292254; ENSP00000292254; ENSG00000160753. [Q9BVN2-2]
ENST00000368347; ENSP00000357331; ENSG00000160753.
ENST00000368349; ENSP00000357333; ENSG00000160753. [Q9BVN2-2]
ENST00000368352; ENSP00000357336; ENSG00000160753. [Q9BVN2-1]
GeneID23623.
KEGGhsa:23623.
UCSCuc001fkj.2. human. [Q9BVN2-1]
uc001fkp.3. human. [Q9BVN2-2]

Organism-specific databases

CTD23623.
GeneCardsGC01P155290.
H-InvDBHIX0116321.
HGNCHGNC:17153. RUSC1.
HPAHPA028510.
HPA029922.
HPA029923.
neXtProtNX_Q9BVN2.
PharmGKBPA134947113.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG47427.
HOGENOMHOG000010280.
HOVERGENHBG058522.
InParanoidQ9BVN2.
OMAWKTNTGI.
OrthoDBEOG757CWF.
PhylomeDBQ9BVN2.
TreeFamTF332235.

Gene expression databases

ArrayExpressQ9BVN2.
BgeeQ9BVN2.
CleanExHS_RUSC1.
GenevestigatorQ9BVN2.

Family and domain databases

InterProIPR004012. Run.
IPR001452. SH3_domain.
[Graphical view]
PfamPF02759. RUN. 1 hit.
[Graphical view]
SMARTSM00593. RUN. 1 hit.
SM00326. SH3. 1 hit.
[Graphical view]
SUPFAMSSF50044. SSF50044. 1 hit.
PROSITEPS50826. RUN. 1 hit.
PS50002. SH3. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GenomeRNAi23623.
NextBio46368.
PROQ9BVN2.

Entry information

Entry nameRUSC1_HUMAN
AccessionPrimary (citable) accession number: Q9BVN2
Secondary accession number(s): B3KWM9 expand/collapse secondary AC list , Q5T9U9, Q5T9V0, Q5T9V1, Q5T9V2, Q9UPY4, Q9Y4T5
Entry history
Integrated into UniProtKB/Swiss-Prot: July 19, 2004
Last sequence update: October 23, 2007
Last modified: April 16, 2014
This is version 109 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 1

Human chromosome 1: entries, gene names and cross-references to MIM