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Protein

Gamma-glutamylaminecyclotransferase

Gene

GGACT

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Contributes to degradation of proteins cross-linked by transglutaminases. Degrades the cross-link between a lysine and a glutamic acid residue from two proteins that have been cross-linked by transglutaminases. Catalyzes the formation of 5-oxoproline from L-gamma-glutamyl-L-epsilon-lysine. Inactive with L-gamma-glutamyl-alpha-amino acid substrates such as L-gamma-glutamyl-L-alpha-cysteine and L-gamma-glutamyl-L-alpha-alanine.1 Publication

Catalytic activityi

(Gamma-L-glutamyl)-L-amino acid = 5-oxoproline + L-amino acid.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei82Proton acceptor1 Publication1

GO - Molecular functioni

  • gamma-glutamylcyclotransferase activity Source: UniProtKB

GO - Biological processi

  • cellular modified amino acid catabolic process Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Acyltransferase, Transferase

Enzyme and pathway databases

BioCyciZFISH:ENSG00000134864-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Gamma-glutamylaminecyclotransferase (EC:2.3.2.4)
Short name:
GGACT
Alternative name(s):
AIG2-like domain-containing protein 1
Gamma-glutamylamine cyclotransferase
Gene namesi
Name:GGACT
Synonyms:A2LD1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 13

Organism-specific databases

HGNCiHGNC:25100. GGACT.

Subcellular locationi

GO - Cellular componenti

  • extracellular exosome Source: UniProtKB
Complete GO annotation...

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi82E → A or Q: Loss of activity. 1 Publication1

Organism-specific databases

DisGeNETi87769.
OpenTargetsiENSG00000134864.
PharmGKBiPA164714645.

Polymorphism and mutation databases

BioMutaiGGACT.
DMDMi74752384.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003202031 – 153Gamma-glutamylaminecyclotransferaseAdd BLAST153

Proteomic databases

EPDiQ9BVM4.
MaxQBiQ9BVM4.
PaxDbiQ9BVM4.
PeptideAtlasiQ9BVM4.
PRIDEiQ9BVM4.

Expressioni

Gene expression databases

BgeeiENSG00000134864.
CleanExiHS_A2LD1.
ExpressionAtlasiQ9BVM4. baseline and differential.
GenevisibleiQ9BVM4. HS.

Organism-specific databases

HPAiHPA065320.

Interactioni

Subunit structurei

Monomer.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
HRASLS5Q96KN8-35EBI-10299852,EBI-10290304

Protein-protein interaction databases

BioGridi124581. 2 interactors.
IntActiQ9BVM4. 3 interactors.
STRINGi9606.ENSP00000365426.

Structurei

Secondary structure

1153
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi2 – 6Combined sources5
Helixi17 – 20Combined sources4
Helixi23 – 25Combined sources3
Beta strandi28 – 38Combined sources11
Beta strandi42 – 45Combined sources4
Turni46 – 49Combined sources4
Beta strandi50 – 55Combined sources6
Beta strandi59 – 61Combined sources3
Beta strandi64 – 70Combined sources7
Helixi72 – 81Combined sources10
Turni82 – 86Combined sources5
Beta strandi89 – 98Combined sources10
Beta strandi113 – 121Combined sources9
Helixi126 – 130Combined sources5

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3JUBX-ray1.20A1-153[»]
3JUCX-ray1.20A1-153[»]
3JUDX-ray0.98A1-153[»]
ProteinModelPortaliQ9BVM4.
SMRiQ9BVM4.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9BVM4.

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni7 – 10Substrate binding4

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG4450. Eukaryota.
ENOG4111N8W. LUCA.
GeneTreeiENSGT00390000010543.
HOGENOMiHOG000261862.
HOVERGENiHBG105481.
InParanoidiQ9BVM4.
KOiK19761.
OMAiGQPNHRV.
OrthoDBiEOG091G0S6A.
PhylomeDBiQ9BVM4.
TreeFamiTF323258.

Family and domain databases

CDDicd06661. GGCT_like. 1 hit.
Gene3Di3.10.490.10. 1 hit.
InterProiIPR009288. AIG2-like.
IPR013024. GGCT-like.
[Graphical view]
PfamiPF06094. GGACT. 1 hit.
[Graphical view]
SUPFAMiSSF110857. SSF110857. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9BVM4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MALVFVYGTL KRGQPNHRVL RDGAHGSAAF RARGRTLEPY PLVIAGEHNI
60 70 80 90 100
PWLLHLPGSG RLVEGEVYAV DERMLRFLDD FESCPALYQR TVLRVQLLED
110 120 130 140 150
RAPGAEEPPA PTAVQCFVYS RATFPPEWAQ LPHHDSYDSE GPHGLRYNPR

ENR
Length:153
Mass (Da):17,329
Last modified:March 1, 2004 - v2
Checksum:i1A01F350F761D208
GO

Sequence cautioni

The sequence AAH04360 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK095850 mRNA. Translation: BAG53143.1.
AL136526 Genomic DNA. Translation: CAI39558.1.
CH471085 Genomic DNA. Translation: EAX09037.1.
BC001077 mRNA. Translation: AAH01077.2.
BC004360 mRNA. Translation: AAH04360.1. Different initiation.
CCDSiCCDS45066.1.
RefSeqiNP_001182016.1. NM_001195087.1.
NP_149101.1. NM_033110.2.
XP_005254140.1. XM_005254083.2.
XP_011519431.1. XM_011521129.2.
XP_016876293.1. XM_017020804.1.
UniGeneiHs.350868.

Genome annotation databases

EnsembliENST00000376250; ENSP00000365426; ENSG00000134864.
ENST00000455100; ENSP00000410449; ENSG00000134864.
GeneIDi87769.
KEGGihsa:87769.
UCSCiuc001voq.2. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK095850 mRNA. Translation: BAG53143.1.
AL136526 Genomic DNA. Translation: CAI39558.1.
CH471085 Genomic DNA. Translation: EAX09037.1.
BC001077 mRNA. Translation: AAH01077.2.
BC004360 mRNA. Translation: AAH04360.1. Different initiation.
CCDSiCCDS45066.1.
RefSeqiNP_001182016.1. NM_001195087.1.
NP_149101.1. NM_033110.2.
XP_005254140.1. XM_005254083.2.
XP_011519431.1. XM_011521129.2.
XP_016876293.1. XM_017020804.1.
UniGeneiHs.350868.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3JUBX-ray1.20A1-153[»]
3JUCX-ray1.20A1-153[»]
3JUDX-ray0.98A1-153[»]
ProteinModelPortaliQ9BVM4.
SMRiQ9BVM4.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi124581. 2 interactors.
IntActiQ9BVM4. 3 interactors.
STRINGi9606.ENSP00000365426.

Polymorphism and mutation databases

BioMutaiGGACT.
DMDMi74752384.

Proteomic databases

EPDiQ9BVM4.
MaxQBiQ9BVM4.
PaxDbiQ9BVM4.
PeptideAtlasiQ9BVM4.
PRIDEiQ9BVM4.

Protocols and materials databases

DNASUi87769.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000376250; ENSP00000365426; ENSG00000134864.
ENST00000455100; ENSP00000410449; ENSG00000134864.
GeneIDi87769.
KEGGihsa:87769.
UCSCiuc001voq.2. human.

Organism-specific databases

CTDi87769.
DisGeNETi87769.
GeneCardsiGGACT.
HGNCiHGNC:25100. GGACT.
HPAiHPA065320.
MIMi613378. gene.
neXtProtiNX_Q9BVM4.
OpenTargetsiENSG00000134864.
PharmGKBiPA164714645.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG4450. Eukaryota.
ENOG4111N8W. LUCA.
GeneTreeiENSGT00390000010543.
HOGENOMiHOG000261862.
HOVERGENiHBG105481.
InParanoidiQ9BVM4.
KOiK19761.
OMAiGQPNHRV.
OrthoDBiEOG091G0S6A.
PhylomeDBiQ9BVM4.
TreeFamiTF323258.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000134864-MONOMER.

Miscellaneous databases

EvolutionaryTraceiQ9BVM4.
GenomeRNAii87769.
PROiQ9BVM4.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000134864.
CleanExiHS_A2LD1.
ExpressionAtlasiQ9BVM4. baseline and differential.
GenevisibleiQ9BVM4. HS.

Family and domain databases

CDDicd06661. GGCT_like. 1 hit.
Gene3Di3.10.490.10. 1 hit.
InterProiIPR009288. AIG2-like.
IPR013024. GGCT-like.
[Graphical view]
PfamiPF06094. GGACT. 1 hit.
[Graphical view]
SUPFAMiSSF110857. SSF110857. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiGGACT_HUMAN
AccessioniPrimary (citable) accession number: Q9BVM4
Secondary accession number(s): B3KTN1, Q9BT41
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: March 1, 2004
Last modified: November 30, 2016
This is version 112 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 13
    Human chromosome 13: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families
  5. Uncharacterized protein families (UPF)
    List of uncharacterized protein family (UPF) entries

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.