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Protein

Gamma-glutamylaminecyclotransferase

Gene

GGACT

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Contributes to degradation of proteins cross-linked by transglutaminases by degrading the cross-link between a lysine and a glutamic acid residue. Catalyzes the formation of 5-oxo-L-proline from L-gamma-glutamyl-L-epsilon-lysine. Inactive with L-gamma-glutamyl-alpha-amino acid substrates such as L-gamma-glutamyl-L-alpha-cysteine and L-gamma-glutamyl-L-alpha-alanine.1 Publication

Catalytic activityi

Epsilon-(gamma-L-glutamyl)-L-lysine = L-lysine + 5-oxo-L-proline.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei82Proton acceptor1 Publication1

GO - Molecular functioni

  • gamma-glutamylaminecyclotransferase activity Source: UniProtKB

GO - Biological processi

  • cellular modified amino acid catabolic process Source: UniProtKB

Keywordsi

Molecular functionLyase

Names & Taxonomyi

Protein namesi
Recommended name:
Gamma-glutamylaminecyclotransferase (EC:4.3.2.81 Publication)
Short name:
GGACT
Alternative name(s):
AIG2-like domain-containing protein 1
Gamma-glutamylamine cyclotransferase
Gene namesi
Name:GGACT
Synonyms:A2LD1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 13

Organism-specific databases

EuPathDBiHostDB:ENSG00000134864.10
HGNCiHGNC:25100 GGACT
MIMi613378 gene
neXtProtiNX_Q9BVM4

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi82E → A or Q: Loss of activity. 1 Publication1

Organism-specific databases

OpenTargetsiENSG00000134864
PharmGKBiPA164714645

Chemistry databases

DrugBankiDB01942 Formic Acid

Polymorphism and mutation databases

BioMutaiGGACT
DMDMi74752384

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003202031 – 153Gamma-glutamylaminecyclotransferaseAdd BLAST153

Proteomic databases

EPDiQ9BVM4
MaxQBiQ9BVM4
PaxDbiQ9BVM4
PeptideAtlasiQ9BVM4
PRIDEiQ9BVM4

Expressioni

Gene expression databases

BgeeiENSG00000134864
CleanExiHS_A2LD1
ExpressionAtlasiQ9BVM4 baseline and differential
GenevisibleiQ9BVM4 HS

Organism-specific databases

HPAiHPA065320

Interactioni

Subunit structurei

Monomer.1 Publication

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi124581, 2 interactors
IntActiQ9BVM4, 3 interactors
STRINGi9606.ENSP00000365426

Structurei

Secondary structure

1153
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi2 – 6Combined sources5
Helixi17 – 20Combined sources4
Helixi23 – 25Combined sources3
Beta strandi28 – 38Combined sources11
Beta strandi42 – 45Combined sources4
Turni46 – 49Combined sources4
Beta strandi50 – 55Combined sources6
Beta strandi59 – 61Combined sources3
Beta strandi64 – 70Combined sources7
Helixi72 – 81Combined sources10
Turni82 – 86Combined sources5
Beta strandi89 – 98Combined sources10
Beta strandi113 – 121Combined sources9
Helixi126 – 130Combined sources5

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3JUBX-ray1.20A1-153[»]
3JUCX-ray1.20A1-153[»]
3JUDX-ray0.98A1-153[»]
ProteinModelPortaliQ9BVM4
SMRiQ9BVM4
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9BVM4

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni7 – 10Substrate binding4

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG4450 Eukaryota
ENOG4111N8W LUCA
GeneTreeiENSGT00390000010543
HOGENOMiHOG000261862
HOVERGENiHBG105481
InParanoidiQ9BVM4
KOiK19761
OMAiRYNPREN
OrthoDBiEOG091G0S6A
PhylomeDBiQ9BVM4
TreeFamiTF323258

Family and domain databases

CDDicd06661 GGCT_like, 1 hit
InterProiView protein in InterPro
IPR009288 AIG2-like
IPR013024 GGCT-like
IPR036568 GGCT-like_sf
PfamiView protein in Pfam
PF06094 GGACT, 1 hit
SUPFAMiSSF110857 SSF110857, 1 hit

Sequencei

Sequence statusi: Complete.

Q9BVM4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MALVFVYGTL KRGQPNHRVL RDGAHGSAAF RARGRTLEPY PLVIAGEHNI
60 70 80 90 100
PWLLHLPGSG RLVEGEVYAV DERMLRFLDD FESCPALYQR TVLRVQLLED
110 120 130 140 150
RAPGAEEPPA PTAVQCFVYS RATFPPEWAQ LPHHDSYDSE GPHGLRYNPR

ENR
Length:153
Mass (Da):17,329
Last modified:March 1, 2004 - v2
Checksum:i1A01F350F761D208
GO

Sequence cautioni

The sequence AAH04360 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK095850 mRNA Translation: BAG53143.1
AL136526 Genomic DNA No translation available.
CH471085 Genomic DNA Translation: EAX09037.1
BC001077 mRNA Translation: AAH01077.2
BC004360 mRNA Translation: AAH04360.1 Different initiation.
CCDSiCCDS45066.1
RefSeqiNP_001182016.1, NM_001195087.1
NP_149101.1, NM_033110.2
XP_005254140.1, XM_005254083.2
XP_011519431.1, XM_011521129.2
XP_016876293.1, XM_017020804.1
UniGeneiHs.350868

Genome annotation databases

EnsembliENST00000376250; ENSP00000365426; ENSG00000134864
ENST00000455100; ENSP00000410449; ENSG00000134864
GeneIDi87769
KEGGihsa:87769
UCSCiuc001voq.2 human

Similar proteinsi

Entry informationi

Entry nameiGGACT_HUMAN
AccessioniPrimary (citable) accession number: Q9BVM4
Secondary accession number(s): B3KTN1, Q9BT41
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: March 1, 2004
Last modified: May 23, 2018
This is version 122 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 13
    Human chromosome 13: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families
  5. Uncharacterized protein families (UPF)
    List of uncharacterized protein family (UPF) entries

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