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Protein

Protein DPCD

Gene

DPCD

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

May play a role in the formation or function of ciliated cells.1 Publication

GO - Biological processi

Complete GO annotation...

Enzyme and pathway databases

BioCyciZFISH:ENSG00000166171-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein DPCD
Gene namesi
Name:DPCD
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 10

Organism-specific databases

HGNCiHGNC:24542. DPCD.

Subcellular locationi

GO - Cellular componenti

  • nucleus Source: UniProtKB
Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

DisGeNETi25911.
OpenTargetsiENSG00000166171.
PharmGKBiPA165548502.

Polymorphism and mutation databases

BioMutaiDPCD.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003237231 – 203Protein DPCDAdd BLAST203

Proteomic databases

EPDiQ9BVM2.
MaxQBiQ9BVM2.
PaxDbiQ9BVM2.
PeptideAtlasiQ9BVM2.
PRIDEiQ9BVM2.

PTM databases

iPTMnetiQ9BVM2.
PhosphoSitePlusiQ9BVM2.

Expressioni

Tissue specificityi

Highly expressed in the testis. Weakly expressed in pancreas, skeletal muscle and heart. Expression increases during ciliated cell differentiation.1 Publication

Gene expression databases

BgeeiENSG00000166171.
ExpressionAtlasiQ9BVM2. baseline and differential.
GenevisibleiQ9BVM2. HS.

Organism-specific databases

HPAiHPA036603.
HPA036604.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
RUVBL2Q9Y2306EBI-749988,EBI-352939

Protein-protein interaction databases

BioGridi117415. 12 interactors.
IntActiQ9BVM2. 8 interactors.
STRINGi9606.ENSP00000359170.

Structurei

3D structure databases

ProteinModelPortaliQ9BVM2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the DPCD family.Curated

Phylogenomic databases

eggNOGiENOG410IF54. Eukaryota.
ENOG410XRH0. LUCA.
GeneTreeiENSGT00390000014031.
HOGENOMiHOG000258519.
HOVERGENiHBG056207.
InParanoidiQ9BVM2.
KOiK20800.
OMAiKNIEWRI.
OrthoDBiEOG091G0LMQ.
PhylomeDBiQ9BVM2.
TreeFamiTF324098.

Family and domain databases

InterProiIPR026224. DPCD.
[Graphical view]
PANTHERiPTHR31921. PTHR31921. 1 hit.
PRINTSiPR02065. PROTEINDPCD.

Sequencei

Sequence statusi: Complete.

Q9BVM2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAVTGWLESL RTAQKTALLQ DGRRKVHYLF PDGKEMAEEY DEKTSELLVR
60 70 80 90 100
KWRVKSALGA MGQWQLEVGD PAPLGAGNLG PELIKESNAN PIFMRKDTKM
110 120 130 140 150
SFQWRIRNLP YPKDVYSVSV DQKERCIIVR TTNKKYYKKF SIPDLDRHQL
160 170 180 190 200
PLDDALLSFA HANCTLIISY QKPKEVVVAE SELQKELKKV KTAHSNDGDC

KTQ
Length:203
Mass (Da):23,240
Last modified:March 1, 2004 - v2
Checksum:i2FBEDDA99F975760
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti100M → K in CAB53691 (PubMed:17974005).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_03957456S → R.1 Publication1
Natural variantiVAR_039575156L → S.3 PublicationsCorresponds to variant rs7006dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK290154 mRNA. Translation: BAF82843.1.
AL627424 Genomic DNA. Translation: CAI41040.1.
BC001082 mRNA. Translation: AAH01082.2.
BC031695 mRNA. Translation: AAH31695.1.
AY532267 mRNA. Translation: AAS46252.1.
AL110240 mRNA. Translation: CAB53691.2.
CCDSiCCDS7514.1.
PIRiT14771.
RefSeqiNP_056263.1. NM_015448.2.
UniGeneiHs.658128.
Hs.735511.

Genome annotation databases

EnsembliENST00000370151; ENSP00000359170; ENSG00000166171.
GeneIDi25911.
KEGGihsa:25911.
UCSCiuc001ktn.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK290154 mRNA. Translation: BAF82843.1.
AL627424 Genomic DNA. Translation: CAI41040.1.
BC001082 mRNA. Translation: AAH01082.2.
BC031695 mRNA. Translation: AAH31695.1.
AY532267 mRNA. Translation: AAS46252.1.
AL110240 mRNA. Translation: CAB53691.2.
CCDSiCCDS7514.1.
PIRiT14771.
RefSeqiNP_056263.1. NM_015448.2.
UniGeneiHs.658128.
Hs.735511.

3D structure databases

ProteinModelPortaliQ9BVM2.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi117415. 12 interactors.
IntActiQ9BVM2. 8 interactors.
STRINGi9606.ENSP00000359170.

PTM databases

iPTMnetiQ9BVM2.
PhosphoSitePlusiQ9BVM2.

Polymorphism and mutation databases

BioMutaiDPCD.

Proteomic databases

EPDiQ9BVM2.
MaxQBiQ9BVM2.
PaxDbiQ9BVM2.
PeptideAtlasiQ9BVM2.
PRIDEiQ9BVM2.

Protocols and materials databases

DNASUi25911.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000370151; ENSP00000359170; ENSG00000166171.
GeneIDi25911.
KEGGihsa:25911.
UCSCiuc001ktn.4. human.

Organism-specific databases

CTDi25911.
DisGeNETi25911.
GeneCardsiDPCD.
HGNCiHGNC:24542. DPCD.
HPAiHPA036603.
HPA036604.
MIMi616467. gene.
neXtProtiNX_Q9BVM2.
OpenTargetsiENSG00000166171.
PharmGKBiPA165548502.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IF54. Eukaryota.
ENOG410XRH0. LUCA.
GeneTreeiENSGT00390000014031.
HOGENOMiHOG000258519.
HOVERGENiHBG056207.
InParanoidiQ9BVM2.
KOiK20800.
OMAiKNIEWRI.
OrthoDBiEOG091G0LMQ.
PhylomeDBiQ9BVM2.
TreeFamiTF324098.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000166171-MONOMER.

Miscellaneous databases

ChiTaRSiDPCD. human.
GenomeRNAii25911.
PROiQ9BVM2.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000166171.
ExpressionAtlasiQ9BVM2. baseline and differential.
GenevisibleiQ9BVM2. HS.

Family and domain databases

InterProiIPR026224. DPCD.
[Graphical view]
PANTHERiPTHR31921. PTHR31921. 1 hit.
PRINTSiPR02065. PROTEINDPCD.
ProtoNetiSearch...

Entry informationi

Entry nameiDPCD_HUMAN
AccessioniPrimary (citable) accession number: Q9BVM2
Secondary accession number(s): A8K289
, Q6QNL3, Q8N5R1, Q9UFY6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 18, 2008
Last sequence update: March 1, 2004
Last modified: November 30, 2016
This is version 117 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.