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Protein

Selenoprotein O

Gene

SELENOO

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

May be a redox-active mitochondrial selenoprotein which interacts with a redox target protein.1 Publication

Names & Taxonomyi

Protein namesi
Recommended name:
Selenoprotein O1 Publication
Short name:
SelO3 Publications
Gene namesi
Name:SELENOOImported
Synonyms:SELO3 Publications
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 22

Organism-specific databases

HGNCiHGNC:30395. SELENOO.

Subcellular locationi

GO - Cellular componenti

  • mitochondrion Source: UniProtKB

Keywords - Cellular componenti

Mitochondrion

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi664 – 667CVTU → SVTC: Enhances redox complex formation. 1 Publication4
Mutagenesisi664 – 667CVTU → SVTS: Abolishes redox complex formation. 1 Publication4
Mutagenesisi664C → S: No effect on redox complex formation. 1 Publication1
Mutagenesisi667U → C: Slightly enhances redox complex formation. 1 Publication1
Mutagenesisi667U → S: No effect on redox complex formation. 1 Publication1

Organism-specific databases

DisGeNETi83642.
OpenTargetsiENSG00000073169.

Polymorphism and mutation databases

BioMutaiSELO.
DMDMi172045770.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001213991 – 669Selenoprotein OAdd BLAST669

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei635PhosphothreonineCombined sources1
Modified residuei653PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ9BVL4.
MaxQBiQ9BVL4.
PaxDbiQ9BVL4.
PeptideAtlasiQ9BVL4.
PRIDEiQ9BVL4.

PTM databases

iPTMnetiQ9BVL4.
PhosphoSitePlusiQ9BVL4.
SwissPalmiQ9BVL4.

Interactioni

Protein-protein interaction databases

BioGridi123706. 18 interactors.
STRINGi9606.ENSP00000370288.

Family & Domainsi

Sequence similaritiesi

Belongs to the UPF0061 (SELO) family.Curated

Phylogenomic databases

eggNOGiKOG2542. Eukaryota.
COG0397. LUCA.
GeneTreeiENSGT00390000005508.
HOGENOMiHOG000008335.
HOVERGENiHBG044520.
InParanoidiQ9BVL4.
OMAiMYLGEVC.
PhylomeDBiQ9BVL4.

Family and domain databases

HAMAPiMF_00692. UPF0061. 1 hit.
InterProiView protein in InterPro
IPR003846. UPF0061.
PfamiView protein in Pfam
PF02696. UPF0061. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9BVL4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAVYRAALGA SLAAARLLPL GRCSPSPAPR STLSGAAMEP APRWLAGLRF
60 70 80 90 100
DNRALRALPV EAPPPGPEGA PSAPRPVPGA CFTRVQPTPL RQPRLVALSE
110 120 130 140 150
PALALLGLGA PPAREAEAEA ALFFSGNALL PGAEPAAHCY CGHQFGQFAG
160 170 180 190 200
QLGDGAAMYL GEVCTATGER WELQLKGAGP TPFSRQADGR KVLRSSIREF
210 220 230 240 250
LCSEAMFHLG VPTTRAGACV TSESTVVRDV FYDGNPKYEQ CTVVLRVAST
260 270 280 290 300
FIRFGSFEIF KSADEHTGRA GPSVGRNDIR VQLLDYVISS FYPEIQAAHA
310 320 330 340 350
SDSVQRNAAF FREVTRRTAR MVAEWQCVGF CHGVLNTDNM SILGLTIDYG
360 370 380 390 400
PFGFLDRYDP DHVCNASDNT GRYAYSKQPE VCRWNLRKLA EALQPELPLE
410 420 430 440 450
LGEAILAEEF DAEFQRHYLQ KMRRKLGLVQ VELEEDGALV SKLLETMHLT
460 470 480 490 500
GADFTNTFYL LSSFPVELES PGLAEFLARL MEQCASLEEL RLAFRPQMDP
510 520 530 540 550
RQLSMMLMLA QSNPQLFALM GTRAGIAREL ERVEQQSRLE QLSAAELQSR
560 570 580 590 600
NQGHWADWLQ AYRARLDKDL EGAGDAAAWQ AEHVRVMHAN NPKYVLRNYI
610 620 630 640 650
AQNAIEAAER GDFSEVRRVL KLLETPYHCE AGAATDAEAT EADGADGRQR
660
SYSSKPPLWA AELCVTUSS
Length:669
Mass (Da):73,489
Last modified:February 26, 2008 - v3
Checksum:iF2242E25B2E0EE68
GO

Sequence cautioni

The sequence AAH01099 differs from that shown. Reason: Erroneous termination at position 667. Translated as Sec.Curated
The sequence AAH20510 differs from that shown. Reason: Erroneous termination at position 667. Translated as Sec.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti253R → RGWGQVWPVDASGLPSR in AAH20510 (PubMed:15489334).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_0599523V → A1 PublicationCorresponds to variant dbSNP:rs5771225Ensembl.1
Natural variantiVAR_059953167T → N1 PublicationCorresponds to variant dbSNP:rs2272846Ensembl.1
Natural variantiVAR_059954630E → K. Corresponds to variant dbSNP:rs2272852Ensembl.1
Natural variantiVAR_059955638E → K. Corresponds to variant dbSNP:rs17013238Ensembl.1

Non-standard residue

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-standard residuei667Selenocysteine1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY324823 mRNA. Translation: AAP85540.1.
AL022328 Genomic DNA. No translation available.
BC001099 mRNA. Translation: AAH01099.3. Sequence problems.
BC020510 mRNA. Translation: AAH20510.1. Sequence problems.
BC110866 mRNA. Translation: AAI10867.1.
CCDSiCCDS43034.1.
RefSeqiNP_113642.1. NM_031454.1.
UniGeneiHs.365405.

Genome annotation databases

EnsembliENST00000380903; ENSP00000370288; ENSG00000073169.
GeneDBiSmp_196150.1:pep.
GeneIDi83642.
KEGGihsa:83642.

Keywords - Coding sequence diversityi

Polymorphism, Selenocysteine

Similar proteinsi

Entry informationi

Entry nameiSELO_HUMAN
AccessioniPrimary (citable) accession number: Q9BVL4
Secondary accession number(s): Q2TAL2, Q5JZ81, Q8WUI0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 4, 2003
Last sequence update: February 26, 2008
Last modified: August 30, 2017
This is version 123 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 22
    Human chromosome 22: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families
  6. Uncharacterized protein families (UPF)
    List of uncharacterized protein family (UPF) entries