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Protein

Selenoprotein O

Gene

SELO

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Enzyme and pathway databases

BioCyciZFISH:ENSG00000073169-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Selenoprotein O
Short name:
SelO
Gene namesi
Name:SELO
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Unplaced

Pathology & Biotechi

Organism-specific databases

DisGeNETi83642.
OpenTargetsiENSG00000073169.

Polymorphism and mutation databases

BioMutaiSELO.
DMDMi172045770.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001213991 – 669Selenoprotein OAdd BLAST669

Proteomic databases

EPDiQ9BVL4.
MaxQBiQ9BVL4.
PaxDbiQ9BVL4.
PeptideAtlasiQ9BVL4.
PRIDEiQ9BVL4.

PTM databases

iPTMnetiQ9BVL4.
PhosphoSitePlusiQ9BVL4.
SwissPalmiQ9BVL4.

Expressioni

Gene expression databases

BgeeiENSG00000073169.

Interactioni

Protein-protein interaction databases

BioGridi123706. 14 interactors.
STRINGi9606.ENSP00000370288.

Family & Domainsi

Sequence similaritiesi

Belongs to the UPF0061 (SELO) family.Curated

Phylogenomic databases

eggNOGiKOG2542. Eukaryota.
COG0397. LUCA.
GeneTreeiENSGT00390000005508.
HOGENOMiHOG000008335.
HOVERGENiHBG044520.
InParanoidiQ9BVL4.
OMAiPVPGACF.
PhylomeDBiQ9BVL4.

Family and domain databases

HAMAPiMF_00692. UPF0061. 1 hit.
InterProiIPR003846. UPF0061.
[Graphical view]
PfamiPF02696. UPF0061. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9BVL4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAVYRAALGA SLAAARLLPL GRCSPSPAPR STLSGAAMEP APRWLAGLRF
60 70 80 90 100
DNRALRALPV EAPPPGPEGA PSAPRPVPGA CFTRVQPTPL RQPRLVALSE
110 120 130 140 150
PALALLGLGA PPAREAEAEA ALFFSGNALL PGAEPAAHCY CGHQFGQFAG
160 170 180 190 200
QLGDGAAMYL GEVCTATGER WELQLKGAGP TPFSRQADGR KVLRSSIREF
210 220 230 240 250
LCSEAMFHLG VPTTRAGACV TSESTVVRDV FYDGNPKYEQ CTVVLRVAST
260 270 280 290 300
FIRFGSFEIF KSADEHTGRA GPSVGRNDIR VQLLDYVISS FYPEIQAAHA
310 320 330 340 350
SDSVQRNAAF FREVTRRTAR MVAEWQCVGF CHGVLNTDNM SILGLTIDYG
360 370 380 390 400
PFGFLDRYDP DHVCNASDNT GRYAYSKQPE VCRWNLRKLA EALQPELPLE
410 420 430 440 450
LGEAILAEEF DAEFQRHYLQ KMRRKLGLVQ VELEEDGALV SKLLETMHLT
460 470 480 490 500
GADFTNTFYL LSSFPVELES PGLAEFLARL MEQCASLEEL RLAFRPQMDP
510 520 530 540 550
RQLSMMLMLA QSNPQLFALM GTRAGIAREL ERVEQQSRLE QLSAAELQSR
560 570 580 590 600
NQGHWADWLQ AYRARLDKDL EGAGDAAAWQ AEHVRVMHAN NPKYVLRNYI
610 620 630 640 650
AQNAIEAAER GDFSEVRRVL KLLETPYHCE AGAATDAEAT EADGADGRQR
660
SYSSKPPLWA AELCVTUSS
Length:669
Mass (Da):73,489
Last modified:February 26, 2008 - v3
Checksum:iF2242E25B2E0EE68
GO

Sequence cautioni

The sequence AAH01099 differs from that shown. Reason: Erroneous termination at position 667. Translated as Sec.Curated
The sequence AAH20510 differs from that shown. Reason: Erroneous termination at position 667. Translated as Sec.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti253R → RGWGQVWPVDASGLPSR in AAH20510 (PubMed:15489334).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_0599523V → A.1 PublicationCorresponds to variant rs5771225dbSNPEnsembl.1
Natural variantiVAR_059953167T → N.1 PublicationCorresponds to variant rs2272846dbSNPEnsembl.1
Natural variantiVAR_059954630E → K.Corresponds to variant rs2272852dbSNPEnsembl.1
Natural variantiVAR_059955638E → K.Corresponds to variant rs17013238dbSNPEnsembl.1

Non-standard residue

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-standard residuei667Selenocysteine1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY324823 mRNA. Translation: AAP85540.1.
AL022328 Genomic DNA. No translation available.
BC001099 mRNA. Translation: AAH01099.3. Sequence problems.
BC020510 mRNA. Translation: AAH20510.1. Sequence problems.
BC110866 mRNA. Translation: AAI10867.1.
CCDSiCCDS43034.1.
RefSeqiNP_113642.1. NM_031454.1.
UniGeneiHs.365405.

Genome annotation databases

GeneDBiSmp_196150.1:pep.
GeneIDi83642.
KEGGihsa:83642.

Keywords - Coding sequence diversityi

Polymorphism, Selenocysteine

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY324823 mRNA. Translation: AAP85540.1.
AL022328 Genomic DNA. No translation available.
BC001099 mRNA. Translation: AAH01099.3. Sequence problems.
BC020510 mRNA. Translation: AAH20510.1. Sequence problems.
BC110866 mRNA. Translation: AAI10867.1.
CCDSiCCDS43034.1.
RefSeqiNP_113642.1. NM_031454.1.
UniGeneiHs.365405.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi123706. 14 interactors.
STRINGi9606.ENSP00000370288.

PTM databases

iPTMnetiQ9BVL4.
PhosphoSitePlusiQ9BVL4.
SwissPalmiQ9BVL4.

Polymorphism and mutation databases

BioMutaiSELO.
DMDMi172045770.

Proteomic databases

EPDiQ9BVL4.
MaxQBiQ9BVL4.
PaxDbiQ9BVL4.
PeptideAtlasiQ9BVL4.
PRIDEiQ9BVL4.

Protocols and materials databases

DNASUi83642.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneDBiSmp_196150.1:pep.
GeneIDi83642.
KEGGihsa:83642.

Organism-specific databases

CTDi83642.
DisGeNETi83642.
GeneCardsiSELO.
H-InvDBHIX0027838.
MIMi607917. gene.
neXtProtiNX_Q9BVL4.
OpenTargetsiENSG00000073169.

Phylogenomic databases

eggNOGiKOG2542. Eukaryota.
COG0397. LUCA.
GeneTreeiENSGT00390000005508.
HOGENOMiHOG000008335.
HOVERGENiHBG044520.
InParanoidiQ9BVL4.
OMAiPVPGACF.
PhylomeDBiQ9BVL4.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000073169-MONOMER.

Miscellaneous databases

ChiTaRSiSELO. human.
GenomeRNAii83642.
PROiQ9BVL4.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000073169.

Family and domain databases

HAMAPiMF_00692. UPF0061. 1 hit.
InterProiIPR003846. UPF0061.
[Graphical view]
PfamiPF02696. UPF0061. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSELO_HUMAN
AccessioniPrimary (citable) accession number: Q9BVL4
Secondary accession number(s): Q2TAL2, Q5JZ81, Q8WUI0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 4, 2003
Last sequence update: February 26, 2008
Last modified: November 2, 2016
This is version 118 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 22
    Human chromosome 22: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families
  6. Uncharacterized protein families (UPF)
    List of uncharacterized protein family (UPF) entries

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.