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Protein

Nucleoporin p58/p45

Gene

NUPL1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Component of the nuclear pore complex, a complex required for the trafficking across the nuclear membrane.By similarity

GO - Molecular functioni

  1. nucleocytoplasmic transporter activity Source: Ensembl

GO - Biological processi

  1. carbohydrate metabolic process Source: Reactome
  2. cytokine-mediated signaling pathway Source: Reactome
  3. gene expression Source: Reactome
  4. glucose transport Source: Reactome
  5. hexose transport Source: Reactome
  6. mitotic cell cycle Source: Reactome
  7. mitotic nuclear envelope disassembly Source: Reactome
  8. mRNA transport Source: UniProtKB-KW
  9. pathogenesis Source: Reactome
  10. protein transport Source: UniProtKB-KW
  11. regulation of glucose transport Source: Reactome
  12. small molecule metabolic process Source: Reactome
  13. transmembrane transport Source: Reactome
  14. viral life cycle Source: Reactome
  15. viral process Source: Reactome
  16. viral transcription Source: Reactome
Complete GO annotation...

Keywords - Biological processi

mRNA transport, Protein transport, Translocation, Transport

Enzyme and pathway databases

ReactomeiREACT_115831. ISG15 antiviral mechanism.
REACT_163931. Nuclear Pore Complex (NPC) Disassembly.
REACT_268530. Transcriptional regulation by small RNAs.
REACT_6190. Rev-mediated nuclear export of HIV RNA.
REACT_6354. Viral Messenger RNA Synthesis.
REACT_6804. Regulation of Glucokinase by Glucokinase Regulatory Protein.
REACT_7991. Vpr-mediated nuclear import of PICs.
REACT_9395. Nuclear import of Rev protein.

Names & Taxonomyi

Protein namesi
Recommended name:
Nucleoporin p58/p45
Alternative name(s):
Nucleoporin-like protein 1
Gene namesi
Name:NUPL1
Synonyms:KIAA0410
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 13

Organism-specific databases

HGNCiHGNC:20261. NUPL1.

Subcellular locationi

  1. Nucleusnuclear pore complex By similarity
  2. Nucleus membrane By similarity; Peripheral membrane protein By similarity; Cytoplasmic side By similarity
  3. Nucleus membrane By similarity; Peripheral membrane protein By similarity; Nucleoplasmic side By similarity

  4. Note: Biased towards cytoplasmic side. Central region of the nuclear pore complex, within the transporter (By similarity).By similarity

GO - Cellular componenti

  1. nuclear envelope Source: Reactome
  2. nuclear membrane Source: UniProtKB-SubCell
  3. nuclear pore Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Nuclear pore complex, Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134981903.

Polymorphism and mutation databases

BioMutaiNUPL1.
DMDMi44888845.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 599599Nucleoporin p58/p45PRO_0000204892Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei331 – 3311Phosphothreonine2 Publications

Post-translational modificationi

O-glycosylated.By similarity

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

MaxQBiQ9BVL2.
PaxDbiQ9BVL2.
PRIDEiQ9BVL2.

PTM databases

PhosphoSiteiQ9BVL2.

Expressioni

Gene expression databases

BgeeiQ9BVL2.
CleanExiHS_NUPL1.
ExpressionAtlasiQ9BVL2. baseline and differential.
GenevestigatoriQ9BVL2.

Organism-specific databases

HPAiHPA039360.

Interactioni

Subunit structurei

Component of the p62 complex, a complex at least composed of NUP62, NUP54, and NUPL1. Interacts with NUTF2. Interacts with SRP1-alpha and Importin p97 proteins when they are together, but not with SRP1-alpha protein alone (By similarity).By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
ABI3Q9P2A44EBI-2811583,EBI-742038
HTTP428584EBI-2811583,EBI-466029
NUP54Q7Z3B43EBI-2811583,EBI-741048
NUP62P371984EBI-2811583,EBI-347978
TRAF1Q130773EBI-2811583,EBI-359224
UBQLN1Q9UMX0-23EBI-2811583,EBI-10173939

Protein-protein interaction databases

BioGridi115157. 28 interactions.
IntActiQ9BVL2. 9 interactions.
STRINGi9606.ENSP00000371155.

Structurei

Secondary structure

1
599
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi345 – 37127Combined sources
Turni372 – 3765Combined sources
Helixi382 – 42443Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4JO7X-ray1.75A/C/E/G341-428[»]
4JO9X-ray2.50B341-426[»]
4JQ5X-ray2.20A/B/C/D/E/F/G/H/I/J/K/L341-425[»]
SMRiQ9BVL2. Positions 343-427.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati7 – 821
Repeati30 – 3122
Repeati44 – 4523
Repeati63 – 6424
Repeati68 – 6925
Repeati488 – 48926
Repeati492 – 49327
Repeati513 – 51428
Repeati519 – 52029
Repeati529 – 530210
Repeati531 – 532211
Repeati545 – 546212
Repeati568 – 569213
Repeati578 – 579214

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni7 – 57957314 X 2 AA repeats of F-GAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili256 – 27621Sequence AnalysisAdd
BLAST
Coiled coili314 – 38168Sequence AnalysisAdd
BLAST

Domaini

Contains FG repeats.

Sequence similaritiesi

Belongs to the NUPL1 family.Curated

Keywords - Domaini

Coiled coil, Repeat

Phylogenomic databases

eggNOGiNOG148149.
GeneTreeiENSGT00730000111111.
HOGENOMiHOG000273874.
HOVERGENiHBG052703.
InParanoidiQ9BVL2.
KOiK14307.
OMAiICQDVDN.
OrthoDBiEOG7H1JN7.
PhylomeDBiQ9BVL2.
TreeFamiTF106502.

Family and domain databases

InterProiIPR024882. Nucleoporin_p58/p45.
[Graphical view]
PANTHERiPTHR13437. PTHR13437. 1 hit.

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9BVL2-1) [UniParc]FASTAAdd to basket

Also known as: p58

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSTGFSFGSG TLGSTTVAAG GTSTGGVFSF GTGASSNPSV GLNFGNLGST
60 70 80 90 100
STPATTSAPS SGFGTGLFGS KPATGFTLGG TNTGIATTIT TGLTLGTPAT
110 120 130 140 150
TSAATTGFSL GFNKPAASAT PFALPITSTS ASGLTLSSAL TSTPAASTGF
160 170 180 190 200
TLNNLGGTTA TTTTASTGLS LGGALAGLGG SLFQSTNTGT SGLGQNALGL
210 220 230 240 250
TLGTTAATST AGNEGLGGID FSSSSDKKSD KTGTRPEDSK ALKDENLPPV
260 270 280 290 300
ICQDVENLQK FVKEQKQVQE EISRMSSKAM LKVQEDIKAL KQLLSLAANG
310 320 330 340 350
IQRNTLNIDK LKIETAQELK NAEIALRTQK TPPGLQHEYA APADYFRILV
360 370 380 390 400
QQFEVQLQQY RQQIEELENH LATQANNSHI TPQDLSMAMQ KIYQTFVALA
410 420 430 440 450
AQLQSIHENV KVLKEQYLGY RKMFLGDAVD VFETRRAEAK KWQNTPRVTT
460 470 480 490 500
GPTPFSTMPN AAAVAMAATL TQQQQPATGP QPSLGVSFGT PFGSGIGTGL
510 520 530 540 550
QSSGLGSSNL GGFGTSSGFG CSTTGASTFG FGTTNKPSGS LSAGFGSSST
560 570 580 590
SGFNFSNPGI TASAGLTFGV SNPASAGFGT GGQLLQLKKP PAGNKRGKR
Length:599
Mass (Da):60,897
Last modified:June 1, 2001 - v1
Checksum:i2CC32E2A1B9E5132
GO
Isoform 2 (identifier: Q9BVL2-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     480-485: PQPSLG → LNAFKL
     486-599: Missing.

Show »
Length:485
Mass (Da):50,210
Checksum:iFC22003B927D904F
GO
Isoform 3 (identifier: Q9BVL2-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     84-95: Missing.

Note: No experimental confirmation available.

Show »
Length:587
Mass (Da):59,754
Checksum:i741B3A6CA2FAE06A
GO

Sequence cautioni

The sequence BAA23706.2 differs from that shown. Reason: Erroneous initiation. Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti34 – 341A → T.1 Publication
Corresponds to variant rs12871898 [ dbSNP | Ensembl ].
VAR_050570
Natural varianti166 – 1661S → P.
Corresponds to variant rs12871608 [ dbSNP | Ensembl ].
VAR_050571

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei84 – 9512Missing in isoform 3. 1 PublicationVSP_045658Add
BLAST
Alternative sequencei480 – 4856PQPSLG → LNAFKL in isoform 2. 1 PublicationVSP_007946
Alternative sequencei486 – 599114Missing in isoform 2. 1 PublicationVSP_007947Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB007870 mRNA. Translation: BAA23706.2. Different initiation.
AK302946 mRNA. Translation: BAG64103.1.
AL138958, AL590787, AL646102 Genomic DNA. Translation: CAH71290.1.
AL590787, AL138958, AL646102 Genomic DNA. Translation: CAI39898.1.
AL590787 Genomic DNA. Translation: CAI39901.1.
AL646102, AL138958, AL590787 Genomic DNA. Translation: CAH72184.1.
BC001104 mRNA. Translation: AAH01104.1.
CCDSiCCDS31949.1. [Q9BVL2-3]
CCDS9314.1. [Q9BVL2-1]
RefSeqiNP_001008564.1. NM_001008564.1. [Q9BVL2-3]
NP_054808.1. NM_014089.3. [Q9BVL2-1]
UniGeneiHs.507537.
Hs.718943.
Hs.732064.

Genome annotation databases

EnsembliENST00000381718; ENSP00000371137; ENSG00000139496. [Q9BVL2-3]
ENST00000381736; ENSP00000371155; ENSG00000139496. [Q9BVL2-1]
ENST00000463407; ENSP00000418555; ENSG00000139496. [Q9BVL2-2]
GeneIDi9818.
KEGGihsa:9818.
UCSCiuc001uqg.1. human. [Q9BVL2-2]
uc001uqi.3. human. [Q9BVL2-1]

Polymorphism and mutation databases

BioMutaiNUPL1.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB007870 mRNA. Translation: BAA23706.2. Different initiation.
AK302946 mRNA. Translation: BAG64103.1.
AL138958, AL590787, AL646102 Genomic DNA. Translation: CAH71290.1.
AL590787, AL138958, AL646102 Genomic DNA. Translation: CAI39898.1.
AL590787 Genomic DNA. Translation: CAI39901.1.
AL646102, AL138958, AL590787 Genomic DNA. Translation: CAH72184.1.
BC001104 mRNA. Translation: AAH01104.1.
CCDSiCCDS31949.1. [Q9BVL2-3]
CCDS9314.1. [Q9BVL2-1]
RefSeqiNP_001008564.1. NM_001008564.1. [Q9BVL2-3]
NP_054808.1. NM_014089.3. [Q9BVL2-1]
UniGeneiHs.507537.
Hs.718943.
Hs.732064.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4JO7X-ray1.75A/C/E/G341-428[»]
4JO9X-ray2.50B341-426[»]
4JQ5X-ray2.20A/B/C/D/E/F/G/H/I/J/K/L341-425[»]
SMRiQ9BVL2. Positions 343-427.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi115157. 28 interactions.
IntActiQ9BVL2. 9 interactions.
STRINGi9606.ENSP00000371155.

PTM databases

PhosphoSiteiQ9BVL2.

Polymorphism and mutation databases

BioMutaiNUPL1.
DMDMi44888845.

Proteomic databases

MaxQBiQ9BVL2.
PaxDbiQ9BVL2.
PRIDEiQ9BVL2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000381718; ENSP00000371137; ENSG00000139496. [Q9BVL2-3]
ENST00000381736; ENSP00000371155; ENSG00000139496. [Q9BVL2-1]
ENST00000463407; ENSP00000418555; ENSG00000139496. [Q9BVL2-2]
GeneIDi9818.
KEGGihsa:9818.
UCSCiuc001uqg.1. human. [Q9BVL2-2]
uc001uqi.3. human. [Q9BVL2-1]

Organism-specific databases

CTDi9818.
GeneCardsiGC13P025875.
HGNCiHGNC:20261. NUPL1.
HPAiHPA039360.
MIMi607615. gene.
neXtProtiNX_Q9BVL2.
PharmGKBiPA134981903.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG148149.
GeneTreeiENSGT00730000111111.
HOGENOMiHOG000273874.
HOVERGENiHBG052703.
InParanoidiQ9BVL2.
KOiK14307.
OMAiICQDVDN.
OrthoDBiEOG7H1JN7.
PhylomeDBiQ9BVL2.
TreeFamiTF106502.

Enzyme and pathway databases

ReactomeiREACT_115831. ISG15 antiviral mechanism.
REACT_163931. Nuclear Pore Complex (NPC) Disassembly.
REACT_268530. Transcriptional regulation by small RNAs.
REACT_6190. Rev-mediated nuclear export of HIV RNA.
REACT_6354. Viral Messenger RNA Synthesis.
REACT_6804. Regulation of Glucokinase by Glucokinase Regulatory Protein.
REACT_7991. Vpr-mediated nuclear import of PICs.
REACT_9395. Nuclear import of Rev protein.

Miscellaneous databases

ChiTaRSiNUPL1. human.
GeneWikiiNUPL1.
GenomeRNAii9818.
NextBioi35476494.
PROiQ9BVL2.
SOURCEiSearch...

Gene expression databases

BgeeiQ9BVL2.
CleanExiHS_NUPL1.
ExpressionAtlasiQ9BVL2. baseline and differential.
GenevestigatoriQ9BVL2.

Family and domain databases

InterProiIPR024882. Nucleoporin_p58/p45.
[Graphical view]
PANTHERiPTHR13437. PTHR13437. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "Prediction of the coding sequences of unidentified human genes. VIII. 78 new cDNA clones from brain which code for large proteins in vitro."
    Ishikawa K., Nagase T., Nakajima D., Seki N., Ohira M., Miyajima N., Tanaka A., Kotani H., Nomura N., Ohara O.
    DNA Res. 4:307-313(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Brain.
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3), VARIANT THR-34.
    Tissue: Testis.
  3. "The DNA sequence and analysis of human chromosome 13."
    Dunham A., Matthews L.H., Burton J., Ashurst J.L., Howe K.L., Ashcroft K.J., Beare D.M., Burford D.C., Hunt S.E., Griffiths-Jones S., Jones M.C., Keenan S.J., Oliver K., Scott C.E., Ainscough R., Almeida J.P., Ambrose K.D., Andrews D.T.
    , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Bannerjee R., Barlow K.F., Bates K., Beasley H., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burrill W., Carder C., Carter N.P., Chapman J.C., Clamp M.E., Clark S.Y., Clarke G., Clee C.M., Clegg S.C., Cobley V., Collins J.E., Corby N., Coville G.J., Deloukas P., Dhami P., Dunham I., Dunn M., Earthrowl M.E., Ellington A.G., Faulkner L., Frankish A.G., Frankland J., French L., Garner P., Garnett J., Gilbert J.G.R., Gilson C.J., Ghori J., Grafham D.V., Gribble S.M., Griffiths C., Hall R.E., Hammond S., Harley J.L., Hart E.A., Heath P.D., Howden P.J., Huckle E.J., Hunt P.J., Hunt A.R., Johnson C., Johnson D., Kay M., Kimberley A.M., King A., Laird G.K., Langford C.J., Lawlor S., Leongamornlert D.A., Lloyd D.M., Lloyd C., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., McLaren S.J., McMurray A., Milne S., Moore M.J.F., Nickerson T., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K.M., Rice C.M., Searle S., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Steward C.A., Sycamore N., Tester J., Thomas D.W., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Wilming L., Wray P.W., Wright M.W., Young L., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Beck S., Bentley D.R., Rogers J., Ross M.T.
    Nature 428:522-528(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Placenta.
  5. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
    Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
    Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-331, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  6. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  7. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."
    Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D., Wang L., Ye M., Zou H.
    J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-331, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.

Entry informationi

Entry nameiNUPL1_HUMAN
AccessioniPrimary (citable) accession number: Q9BVL2
Secondary accession number(s): A6NI12
, B4DZJ1, O43160, Q5JRG2, Q5JRG5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 10, 2003
Last sequence update: June 1, 2001
Last modified: April 29, 2015
This is version 123 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Miscellaneous

In rat, the p62 complex contains two different isoforms of NUPL1. Isoform p45 has however not been isolated in human so far.

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 13
    Human chromosome 13: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.