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Q9BVL2 (NUPL1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 114. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Nucleoporin p58/p45
Alternative name(s):
Nucleoporin-like protein 1
Gene names
Name:NUPL1
Synonyms:KIAA0410
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length599 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Component of the nuclear pore complex, a complex required for the trafficking across the nuclear membrane By similarity.

Subunit structure

Component of the p62 complex, a complex at least composed of NUP62, NUP54, and NUPL1. Interacts with NUTF2. Interacts with SRP1-alpha and Importin p97 proteins when they are together, but not with SRP1-alpha protein alone By similarity.

Subcellular location

Nucleusnuclear pore complex By similarity. Nucleus membrane; Peripheral membrane protein; Cytoplasmic side By similarity. Nucleus membrane; Peripheral membrane protein; Nucleoplasmic side By similarity. Note: Biased towards cytoplasmic side. Central region of the nuclear pore complex, within the transporter By similarity.

Domain

Contains FG repeats.

Post-translational modification

O-glycosylated By similarity.

Miscellaneous

In rat, the p62 complex contains two different isoforms of NUPL1. Isoform p45has however not been isolated in human so far.

Sequence similarities

Belongs to the NUPL1 family.

Sequence caution

The sequence BAA23706.2 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
   Biological processmRNA transport
Protein transport
Translocation
Transport
   Cellular componentMembrane
Nuclear pore complex
Nucleus
   Coding sequence diversityAlternative splicing
Polymorphism
   DomainCoiled coil
Repeat
   PTMGlycoprotein
Phosphoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processcarbohydrate metabolic process

Traceable author statement. Source: Reactome

cytokine-mediated signaling pathway

Traceable author statement. Source: Reactome

glucose transport

Traceable author statement. Source: Reactome

hexose transport

Traceable author statement. Source: Reactome

mRNA transport

Inferred from electronic annotation. Source: UniProtKB-KW

mitotic cell cycle

Traceable author statement. Source: Reactome

mitotic nuclear envelope disassembly

Traceable author statement. Source: Reactome

protein transport

Inferred from electronic annotation. Source: UniProtKB-KW

regulation of glucose transport

Traceable author statement. Source: Reactome

small molecule metabolic process

Traceable author statement. Source: Reactome

transmembrane transport

Traceable author statement. Source: Reactome

viral process

Traceable author statement. Source: Reactome

   Cellular_componentnuclear envelope

Traceable author statement. Source: Reactome

nuclear membrane

Inferred from electronic annotation. Source: UniProtKB-SubCell

nuclear pore

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionnucleocytoplasmic transporter activity

Inferred from electronic annotation. Source: Ensembl

protein binding

Inferred from physical interaction PubMed 17500595PubMed 23275563. Source: IntAct

Complete GO annotation...

Binary interactions

With

Entry

#Exp.

IntAct

Notes

HTTP428584EBI-2811583,EBI-466029

Alternative products

This entry describes 3 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q9BVL2-1)

Also known as: p58;

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q9BVL2-2)

The sequence of this isoform differs from the canonical sequence as follows:
     480-485: PQPSLG → LNAFKL
     486-599: Missing.
Isoform 3 (identifier: Q9BVL2-3)

The sequence of this isoform differs from the canonical sequence as follows:
     84-95: Missing.
Note: No experimental confirmation available.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 599599Nucleoporin p58/p45
PRO_0000204892

Regions

Repeat7 – 821
Repeat30 – 3122
Repeat44 – 4523
Repeat63 – 6424
Repeat68 – 6925
Repeat488 – 48926
Repeat492 – 49327
Repeat513 – 51428
Repeat519 – 52029
Repeat529 – 530210
Repeat531 – 532211
Repeat545 – 546212
Repeat568 – 569213
Repeat578 – 579214
Region7 – 57957314 X 2 AA repeats of F-G
Coiled coil256 – 27621 Potential
Coiled coil314 – 38168 Potential

Amino acid modifications

Modified residue3311Phosphothreonine Ref.5

Natural variations

Alternative sequence84 – 9512Missing in isoform 3.
VSP_045658
Alternative sequence480 – 4856PQPSLG → LNAFKL in isoform 2.
VSP_007946
Alternative sequence486 – 599114Missing in isoform 2.
VSP_007947
Natural variant341A → T. Ref.2
Corresponds to variant rs12871898 [ dbSNP | Ensembl ].
VAR_050570
Natural variant1661S → P.
Corresponds to variant rs12871608 [ dbSNP | Ensembl ].
VAR_050571

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 (p58) [UniParc].

Last modified June 1, 2001. Version 1.
Checksum: 2CC32E2A1B9E5132

FASTA59960,897
        10         20         30         40         50         60 
MSTGFSFGSG TLGSTTVAAG GTSTGGVFSF GTGASSNPSV GLNFGNLGST STPATTSAPS 

        70         80         90        100        110        120 
SGFGTGLFGS KPATGFTLGG TNTGIATTIT TGLTLGTPAT TSAATTGFSL GFNKPAASAT 

       130        140        150        160        170        180 
PFALPITSTS ASGLTLSSAL TSTPAASTGF TLNNLGGTTA TTTTASTGLS LGGALAGLGG 

       190        200        210        220        230        240 
SLFQSTNTGT SGLGQNALGL TLGTTAATST AGNEGLGGID FSSSSDKKSD KTGTRPEDSK 

       250        260        270        280        290        300 
ALKDENLPPV ICQDVENLQK FVKEQKQVQE EISRMSSKAM LKVQEDIKAL KQLLSLAANG 

       310        320        330        340        350        360 
IQRNTLNIDK LKIETAQELK NAEIALRTQK TPPGLQHEYA APADYFRILV QQFEVQLQQY 

       370        380        390        400        410        420 
RQQIEELENH LATQANNSHI TPQDLSMAMQ KIYQTFVALA AQLQSIHENV KVLKEQYLGY 

       430        440        450        460        470        480 
RKMFLGDAVD VFETRRAEAK KWQNTPRVTT GPTPFSTMPN AAAVAMAATL TQQQQPATGP 

       490        500        510        520        530        540 
QPSLGVSFGT PFGSGIGTGL QSSGLGSSNL GGFGTSSGFG CSTTGASTFG FGTTNKPSGS 

       550        560        570        580        590 
LSAGFGSSST SGFNFSNPGI TASAGLTFGV SNPASAGFGT GGQLLQLKKP PAGNKRGKR 

« Hide

Isoform 2 [UniParc].

Checksum: FC22003B927D904F
Show »

FASTA48550,210
Isoform 3 [UniParc].

Checksum: 741B3A6CA2FAE06A
Show »

FASTA58759,754

References

[1]"Prediction of the coding sequences of unidentified human genes. VIII. 78 new cDNA clones from brain which code for large proteins in vitro."
Ishikawa K., Nagase T., Nakajima D., Seki N., Ohira M., Miyajima N., Tanaka A., Kotani H., Nomura N., Ohara O.
DNA Res. 4:307-313(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
Tissue: Brain.
[2]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3), VARIANT THR-34.
Tissue: Testis.
[3]"The DNA sequence and analysis of human chromosome 13."
Dunham A., Matthews L.H., Burton J., Ashurst J.L., Howe K.L., Ashcroft K.J., Beare D.M., Burford D.C., Hunt S.E., Griffiths-Jones S., Jones M.C., Keenan S.J., Oliver K., Scott C.E., Ainscough R., Almeida J.P., Ambrose K.D., Andrews D.T. expand/collapse author list , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Bannerjee R., Barlow K.F., Bates K., Beasley H., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burrill W., Carder C., Carter N.P., Chapman J.C., Clamp M.E., Clark S.Y., Clarke G., Clee C.M., Clegg S.C., Cobley V., Collins J.E., Corby N., Coville G.J., Deloukas P., Dhami P., Dunham I., Dunn M., Earthrowl M.E., Ellington A.G., Faulkner L., Frankish A.G., Frankland J., French L., Garner P., Garnett J., Gilbert J.G.R., Gilson C.J., Ghori J., Grafham D.V., Gribble S.M., Griffiths C., Hall R.E., Hammond S., Harley J.L., Hart E.A., Heath P.D., Howden P.J., Huckle E.J., Hunt P.J., Hunt A.R., Johnson C., Johnson D., Kay M., Kimberley A.M., King A., Laird G.K., Langford C.J., Lawlor S., Leongamornlert D.A., Lloyd D.M., Lloyd C., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., McLaren S.J., McMurray A., Milne S., Moore M.J.F., Nickerson T., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K.M., Rice C.M., Searle S., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Steward C.A., Sycamore N., Tester J., Thomas D.W., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Wilming L., Wray P.W., Wright M.W., Young L., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Beck S., Bentley D.R., Rogers J., Ross M.T.
Nature 428:522-528(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
Tissue: Placenta.
[5]"Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-331, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Cervix carcinoma.
[6]"Initial characterization of the human central proteome."
Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J.
BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AB007870 mRNA. Translation: BAA23706.2. Different initiation.
AK302946 mRNA. Translation: BAG64103.1.
AL138958, AL590787, AL646102 Genomic DNA. Translation: CAH71290.1.
AL590787, AL138958, AL646102 Genomic DNA. Translation: CAI39898.1.
AL590787 Genomic DNA. Translation: CAI39901.1.
AL646102, AL138958, AL590787 Genomic DNA. Translation: CAH72184.1.
BC001104 mRNA. Translation: AAH01104.1.
CCDSCCDS31949.1. [Q9BVL2-3]
CCDS9314.1. [Q9BVL2-1]
RefSeqNP_001008564.1. NM_001008564.1. [Q9BVL2-3]
NP_054808.1. NM_014089.3. [Q9BVL2-1]
UniGeneHs.507537.
Hs.718943.
Hs.732064.

3D structure databases

ProteinModelPortalQ9BVL2.
SMRQ9BVL2. Positions 341-426.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid115157. 9 interactions.
IntActQ9BVL2. 6 interactions.
STRING9606.ENSP00000371155.

PTM databases

PhosphoSiteQ9BVL2.

Polymorphism databases

DMDM44888845.

Proteomic databases

MaxQBQ9BVL2.
PaxDbQ9BVL2.
PRIDEQ9BVL2.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000381718; ENSP00000371137; ENSG00000139496. [Q9BVL2-3]
ENST00000381736; ENSP00000371155; ENSG00000139496. [Q9BVL2-1]
ENST00000463407; ENSP00000418555; ENSG00000139496. [Q9BVL2-2]
GeneID9818.
KEGGhsa:9818.
UCSCuc001uqg.1. human. [Q9BVL2-2]
uc001uqi.3. human. [Q9BVL2-1]

Organism-specific databases

CTD9818.
GeneCardsGC13P025875.
HGNCHGNC:20261. NUPL1.
HPAHPA039360.
MIM607615. gene.
neXtProtNX_Q9BVL2.
PharmGKBPA134981903.
HUGESearch...
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG148149.
HOGENOMHOG000273874.
HOVERGENHBG052703.
InParanoidQ9BVL2.
KOK14307.
OMAYRKTFLG.
OrthoDBEOG7H1JN7.
PhylomeDBQ9BVL2.
TreeFamTF106502.

Enzyme and pathway databases

ReactomeREACT_111217. Metabolism.
REACT_115566. Cell Cycle.
REACT_116125. Disease.
REACT_15518. Transmembrane transport of small molecules.
REACT_21300. Mitotic M-M/G1 phases.
REACT_6900. Immune System.

Gene expression databases

ArrayExpressQ9BVL2.
BgeeQ9BVL2.
CleanExHS_NUPL1.
GenevestigatorQ9BVL2.

Family and domain databases

InterProIPR024882. Nucleoporin_p58/p45.
[Graphical view]
PANTHERPTHR13437. PTHR13437. 1 hit.
ProtoNetSearch...

Other

ChiTaRSNUPL1. human.
GeneWikiNUPL1.
GenomeRNAi9818.
NextBio35476494.
PROQ9BVL2.
SOURCESearch...

Entry information

Entry nameNUPL1_HUMAN
AccessionPrimary (citable) accession number: Q9BVL2
Secondary accession number(s): A6NI12 expand/collapse secondary AC list , B4DZJ1, O43160, Q5JRG2, Q5JRG5
Entry history
Integrated into UniProtKB/Swiss-Prot: October 10, 2003
Last sequence update: June 1, 2001
Last modified: July 9, 2014
This is version 114 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 13

Human chromosome 13: entries, gene names and cross-references to MIM