Q9BVL2 (NUPL1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Nucleoporin p58/p45

Alternative name(s):
Nucleoporin-like protein 1

Gene names

Name:	NUPL1
Synonyms:	KIAA0410

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	599 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Component of the nuclear pore complex, a complex required for the trafficking across the nuclear membrane By similarity.
Subunit structure	Component of the p62 complex, a complex at least composed of NUP62, NUP54, and NUPL1. Interacts with NUTF2. Interacts with SRP1-alpha and Importin p97 proteins when they are together, but not with SRP1-alpha protein alone By similarity.
Subcellular location	Nucleus › nuclear pore complex By similarity. Nucleus membrane; Peripheral membrane protein; Cytoplasmic side By similarity. Nucleus membrane; Peripheral membrane protein; Nucleoplasmic side By similarity. Note: Biased towards cytoplasmic side. Central region of the nuclear pore complex, within the transporter By similarity.
Domain	Contains FG repeats.
Post-translational modification	O-glycosylated By similarity.
Miscellaneous	In rat, the p62 complex contains two different isoforms of NUPL1. Isoform p45 has however not been isolated in human so far.
Sequence similarities	Belongs to the NUPL1 family.
Sequence caution	The sequence BAA23706.2 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
Biological process	Protein transport Translocation Transport mRNA transport
Cellular component	Membrane Nuclear pore complex Nucleus
Coding sequence diversity	Alternative splicing Polymorphism
Domain	Coiled coil Repeat
PTM	Glycoprotein Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	carbohydrate metabolic process Traceable author statement. Source: Reactome cytokine-mediated signaling pathway Traceable author statement. Source: Reactome glucose transport Traceable author statement. Source: Reactome mRNA transport Inferred from electronic annotation. Source: UniProtKB-KW protein transport Inferred from electronic annotation. Source: UniProtKB-KW regulation of glucose transport Traceable author statement. Source: Reactome small molecule metabolic process Traceable author statement. Source: Reactome transmembrane transport Traceable author statement. Source: Reactome viral reproduction Traceable author statement. Source: Reactome
Cellular_component	nuclear envelope Traceable author statement. Source: Reactome nuclear membrane Inferred from electronic annotation. Source: UniProtKB-SubCell nuclear pore Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	nucleocytoplasmic transporter activity Inferred from electronic annotation. Source: Compara
Complete GO annotation...

Alternative products

This entry describes 3 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q9BVL2-1)

Also known as: p58;

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q9BVL2-2)

The sequence of this isoform differs from the canonical sequence as follows:
     480-485: PQPSLG → LNAFKL
     486-599: Missing.

Isoform 3 (identifier: Q9BVL2-3)

The sequence of this isoform differs from the canonical sequence as follows:
     84-95: Missing.

Note: No experimental confirmation available.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 599	599	Nucleoporin p58/p45		PRO_0000204892
Regions
	Repeat	7 – 8	2	1
	Repeat	30 – 31	2	2
	Repeat	44 – 45	2	3
	Repeat	63 – 64	2	4
	Repeat	68 – 69	2	5
	Repeat	488 – 489	2	6
	Repeat	492 – 493	2	7
	Repeat	513 – 514	2	8
	Repeat	519 – 520	2	9
	Repeat	529 – 530	2	10
	Repeat	531 – 532	2	11
	Repeat	545 – 546	2	12
	Repeat	568 – 569	2	13
	Repeat	578 – 579	2	14
	Region	7 – 579	573	14 X 2 AA repeats of F-G
	Coiled coil	256 – 276	21	Potential
	Coiled coil	314 – 381	68	Potential
Amino acid modifications
	Modified residue	331	1	Phosphothreonine Ref.5
Natural variations
	Alternative sequence	84 – 95	12	Missing in isoform 3.		VSP_045658
	Alternative sequence	480 – 485	6	PQPSLG → LNAFKL in isoform 2.		VSP_007946
	Alternative sequence	486 – 599	114	Missing in isoform 2.		VSP_007947
	Natural variant	34	1	A → T. Ref.2 Corresponds to variant rs12871898 [ dbSNP | Ensembl ].		VAR_050570
	Natural variant	166	1	S → P. Corresponds to variant rs12871608 [ dbSNP | Ensembl ].		VAR_050571

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 (p58) [UniParc]. Last modified June 1, 2001. Version 1. Checksum: 2CC32E2A1B9E5132	FASTA	599	60,897
	10 20 30 40 50 60 MSTGFSFGSG TLGSTTVAAG GTSTGGVFSF GTGASSNPSV GLNFGNLGST STPATTSAPS 70 80 90 100 110 120 SGFGTGLFGS KPATGFTLGG TNTGIATTIT TGLTLGTPAT TSAATTGFSL GFNKPAASAT 130 140 150 160 170 180 PFALPITSTS ASGLTLSSAL TSTPAASTGF TLNNLGGTTA TTTTASTGLS LGGALAGLGG 190 200 210 220 230 240 SLFQSTNTGT SGLGQNALGL TLGTTAATST AGNEGLGGID FSSSSDKKSD KTGTRPEDSK 250 260 270 280 290 300 ALKDENLPPV ICQDVENLQK FVKEQKQVQE EISRMSSKAM LKVQEDIKAL KQLLSLAANG 310 320 330 340 350 360 IQRNTLNIDK LKIETAQELK NAEIALRTQK TPPGLQHEYA APADYFRILV QQFEVQLQQY 370 380 390 400 410 420 RQQIEELENH LATQANNSHI TPQDLSMAMQ KIYQTFVALA AQLQSIHENV KVLKEQYLGY 430 440 450 460 470 480 RKMFLGDAVD VFETRRAEAK KWQNTPRVTT GPTPFSTMPN AAAVAMAATL TQQQQPATGP 490 500 510 520 530 540 QPSLGVSFGT PFGSGIGTGL QSSGLGSSNL GGFGTSSGFG CSTTGASTFG FGTTNKPSGS 550 560 570 580 590 LSAGFGSSST SGFNFSNPGI TASAGLTFGV SNPASAGFGT GGQLLQLKKP PAGNKRGKR
	Isoform 2 [UniParc]. Checksum: FC22003B927D904F	FASTA	485	50,210
	10 20 30 40 50 60 MSTGFSFGSG TLGSTTVAAG GTSTGGVFSF GTGASSNPSV GLNFGNLGST STPATTSAPS 70 80 90 100 110 120 SGFGTGLFGS KPATGFTLGG TNTGIATTIT TGLTLGTPAT TSAATTGFSL GFNKPAASAT 130 140 150 160 170 180 PFALPITSTS ASGLTLSSAL TSTPAASTGF TLNNLGGTTA TTTTASTGLS LGGALAGLGG 190 200 210 220 230 240 SLFQSTNTGT SGLGQNALGL TLGTTAATST AGNEGLGGID FSSSSDKKSD KTGTRPEDSK 250 260 270 280 290 300 ALKDENLPPV ICQDVENLQK FVKEQKQVQE EISRMSSKAM LKVQEDIKAL KQLLSLAANG 310 320 330 340 350 360 IQRNTLNIDK LKIETAQELK NAEIALRTQK TPPGLQHEYA APADYFRILV QQFEVQLQQY 370 380 390 400 410 420 RQQIEELENH LATQANNSHI TPQDLSMAMQ KIYQTFVALA AQLQSIHENV KVLKEQYLGY 430 440 450 460 470 480 RKMFLGDAVD VFETRRAEAK KWQNTPRVTT GPTPFSTMPN AAAVAMAATL TQQQQPATGL NAFKL
	Isoform 3 [UniParc]. Checksum: 741B3A6CA2FAE06A	FASTA	587	59,754
	10 20 30 40 50 60 MSTGFSFGSG TLGSTTVAAG GTSTGGVFSF GTGASSNPSV GLNFGNLGST STPATTSAPS 70 80 90 100 110 120 SGFGTGLFGS KPATGFTLGG TNTGTPATTS AATTGFSLGF NKPAASATPF ALPITSTSAS 130 140 150 160 170 180 GLTLSSALTS TPAASTGFTL NNLGGTTATT TTASTGLSLG GALAGLGGSL FQSTNTGTSG 190 200 210 220 230 240 LGQNALGLTL GTTAATSTAG NEGLGGIDFS SSSDKKSDKT GTRPEDSKAL KDENLPPVIC 250 260 270 280 290 300 QDVENLQKFV KEQKQVQEEI SRMSSKAMLK VQEDIKALKQ LLSLAANGIQ RNTLNIDKLK 310 320 330 340 350 360 IETAQELKNA EIALRTQKTP PGLQHEYAAP ADYFRILVQQ FEVQLQQYRQ QIEELENHLA 370 380 390 400 410 420 TQANNSHITP QDLSMAMQKI YQTFVALAAQ LQSIHENVKV LKEQYLGYRK MFLGDAVDVF 430 440 450 460 470 480 ETRRAEAKKW QNTPRVTTGP TPFSTMPNAA AVAMAATLTQ QQQPATGPQP SLGVSFGTPF 490 500 510 520 530 540 GSGIGTGLQS SGLGSSNLGG FGTSSGFGCS TTGASTFGFG TTNKPSGSLS AGFGSSSTSG 550 560 570 580 FNFSNPGITA SAGLTFGVSN PASAGFGTGG QLLQLKKPPA GNKRGKR

References

[1]	"Prediction of the coding sequences of unidentified human genes. VIII. 78 new cDNA clones from brain which code for large proteins in vitro." Ishikawa K., Nagase T., Nakajima D., Seki N., Ohira M., Miyajima N., Tanaka A., Kotani H., Nomura N., Ohara O. DNA Res. 4:307-313(1997) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2). Tissue: Brain.
[2]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3), VARIANT THR-34. Tissue: Testis.
[3]	"The DNA sequence and analysis of human chromosome 13." Dunham A., Matthews L.H., Burton J., Ashurst J.L., Howe K.L., Ashcroft K.J., Beare D.M., Burford D.C., Hunt S.E., Griffiths-Jones S., Jones M.C., Keenan S.J., Oliver K., Scott C.E., Ainscough R., Almeida J.P., Ambrose K.D., Andrews D.T. , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Bannerjee R., Barlow K.F., Bates K., Beasley H., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burrill W., Carder C., Carter N.P., Chapman J.C., Clamp M.E., Clark S.Y., Clarke G., Clee C.M., Clegg S.C., Cobley V., Collins J.E., Corby N., Coville G.J., Deloukas P., Dhami P., Dunham I., Dunn M., Earthrowl M.E., Ellington A.G., Faulkner L., Frankish A.G., Frankland J., French L., Garner P., Garnett J., Gilbert J.G.R., Gilson C.J., Ghori J., Grafham D.V., Gribble S.M., Griffiths C., Hall R.E., Hammond S., Harley J.L., Hart E.A., Heath P.D., Howden P.J., Huckle E.J., Hunt P.J., Hunt A.R., Johnson C., Johnson D., Kay M., Kimberley A.M., King A., Laird G.K., Langford C.J., Lawlor S., Leongamornlert D.A., Lloyd D.M., Lloyd C., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., McLaren S.J., McMurray A., Milne S., Moore M.J.F., Nickerson T., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K.M., Rice C.M., Searle S., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Steward C.A., Sycamore N., Tester J., Thomas D.W., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Wilming L., Wray P.W., Wright M.W., Young L., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Beck S., Bentley D.R., Rogers J., Ross M.T. Nature 428:522-528(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). Tissue: Placenta.
[5]	"Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis." Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M. Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-331, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
[6]	"Initial characterization of the human central proteome." Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J. BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Cross-references

Sequence databases
EMBL GenBank DDBJ	AB007870 mRNA. Translation: BAA23706.2. Different initiation. AK302946 mRNA. Translation: BAG64103.1. AL138958, AL590787, AL646102 Genomic DNA. Translation: CAH71290.1. AL590787, AL138958, AL646102 Genomic DNA. Translation: CAI39898.1. AL590787 Genomic DNA. Translation: CAI39901.1. AL646102, AL138958, AL590787 Genomic DNA. Translation: CAH72184.1. BC001104 mRNA. Translation: AAH01104.1.
IPI	IPI00107122. IPI00550771. IPI00938163.
RefSeq	NP_001008564.1. NM_001008564.1. NP_054808.1. NM_014089.3.
UniGene	Hs.718943. Hs.732064. Hs.741412.
3D structure databases
ProteinModelPortal	Q9BVL2.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q9BVL2. 3 interactions.
STRING	9606.ENSP00000371155.
PTM databases
PhosphoSite	Q9BVL2.
Polymorphism databases
DMDM	44888845.
Proteomic databases
PaxDb	Q9BVL2.
PRIDE	Q9BVL2.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000381718; ENSP00000371137; ENSG00000139496. ENST00000381736; ENSP00000371155; ENSG00000139496. ENST00000463407; ENSP00000418555; ENSG00000139496.
GeneID	9818.
KEGG	hsa:9818.
UCSC	uc001uqg.1. human. uc001uqi.3. human.
Organism-specific databases
CTD	9818.
GeneCards	GC13P025875.
HGNC	HGNC:20261. NUPL1.
HPA	HPA039360.
MIM	607615. gene.
neXtProt	NX_Q9BVL2.
PharmGKB	PA134981903.
HUGE	Search...
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG148149.
HOGENOM	HOG000273874.
HOVERGEN	HBG052703.
InParanoid	Q9BVL2.
KO	K14307.
OMA	HENVKML.
OrthoDB	EOG4FXR8K.
PhylomeDB	Q9BVL2.
Enzyme and pathway databases
Reactome	REACT_111217. Metabolism. REACT_116125. Disease. REACT_15518. Transmembrane transport of small molecules. REACT_6900. Immune System.
Gene expression databases
ArrayExpress	Q9BVL2.
Bgee	Q9BVL2.
CleanEx	HS_NUPL1.
Genevestigator	Q9BVL2.
GermOnline	ENSG00000139496. Homo sapiens.
Family and domain databases
InterPro	IPR024882. Nucleoporin_p58/p45. [Graphical view]
PANTHER	PTHR13437. PTHR13437. 1 hit.
ProtoNet	Search...
Other
ChiTaRS	NUPL1. human.
GenomeRNAi	9818.
NextBio	35476494.
SOURCE	Search...

Entry information

Entry name

NUPL1_HUMAN

Accession

Primary (citable) accession number: Q9BVL2
Secondary accession number(s): A6NI12 , B4DZJ1, O43160, Q5JRG2, Q5JRG5

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 10, 2003
Last sequence update:	June 1, 2001
Last modified:	May 1, 2013
This is version 102 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.