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Protein

Nucleoporin p58/p45

Gene

NUP58

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Component of the nuclear pore complex, a complex required for the trafficking across the nuclear membrane.By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

mRNA transport, Protein transport, Translocation, Transport

Enzyme and pathway databases

BioCyciZFISH:ENSG00000139496-MONOMER.
ReactomeiR-HSA-1169408. ISG15 antiviral mechanism.
R-HSA-159227. Transport of the SLBP independent Mature mRNA.
R-HSA-159230. Transport of the SLBP Dependant Mature mRNA.
R-HSA-159231. Transport of Mature mRNA Derived from an Intronless Transcript.
R-HSA-159236. Transport of Mature mRNA derived from an Intron-Containing Transcript.
R-HSA-165054. Rev-mediated nuclear export of HIV RNA.
R-HSA-168271. Transport of Ribonucleoproteins into the Host Nucleus.
R-HSA-168276. NS1 Mediated Effects on Host Pathways.
R-HSA-168325. Viral Messenger RNA Synthesis.
R-HSA-168333. NEP/NS2 Interacts with the Cellular Export Machinery.
R-HSA-170822. Regulation of Glucokinase by Glucokinase Regulatory Protein.
R-HSA-180746. Nuclear import of Rev protein.
R-HSA-180910. Vpr-mediated nuclear import of PICs.
R-HSA-191859. snRNP Assembly.
R-HSA-3108214. SUMOylation of DNA damage response and repair proteins.
R-HSA-3301854. Nuclear Pore Complex (NPC) Disassembly.
R-HSA-3371453. Regulation of HSF1-mediated heat shock response.
R-HSA-4570464. SUMOylation of RNA binding proteins.
R-HSA-4615885. SUMOylation of DNA replication proteins.
R-HSA-5578749. Transcriptional regulation by small RNAs.
R-HSA-6784531. tRNA processing in the nucleus.

Protein family/group databases

TCDBi1.I.1.1.3. the nuclear pore complex (npc) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Nucleoporin p58/p45Curated
Alternative name(s):
58 kDa nucleoporinImported
Nucleoporin-like protein 1
Gene namesi
Name:NUP58Imported
Synonyms:KIAA0410, NUPL1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 13

Organism-specific databases

HGNCiHGNC:20261. NUP58.

Subcellular locationi

  • Nucleusnuclear pore complex By similarity
  • Nucleus membrane By similarity; Peripheral membrane protein By similarity; Cytoplasmic side By similarity
  • Nucleus membrane By similarity; Peripheral membrane protein By similarity; Nucleoplasmic side By similarity

  • Note: Biased towards cytoplasmic side. Central region of the nuclear pore complex, within the transporter.By similarity

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane, Nuclear pore complex, Nucleus

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000139496.
PharmGKBiPA134981903.

Polymorphism and mutation databases

BioMutaiNUPL1.
DMDMi44888845.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002048921 – 599Nucleoporin p58/p45Add BLAST599

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei331PhosphothreonineCombined sources1

Post-translational modificationi

O-glycosylated.By similarity

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

EPDiQ9BVL2.
MaxQBiQ9BVL2.
PaxDbiQ9BVL2.
PeptideAtlasiQ9BVL2.
PRIDEiQ9BVL2.

PTM databases

iPTMnetiQ9BVL2.
PhosphoSitePlusiQ9BVL2.

Expressioni

Gene expression databases

BgeeiENSG00000139496.
CleanExiHS_NUPL1.
ExpressionAtlasiQ9BVL2. baseline and differential.
GenevisibleiQ9BVL2. HS.

Organism-specific databases

HPAiHPA039360.

Interactioni

Subunit structurei

Component of the p62 complex, a complex at least composed of NUP62, NUP54, and NUP58. Interacts with NUTF2. Interacts with SRP1-alpha and Importin p97 proteins when they are together, but not with SRP1-alpha protein alone (By similarity).By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
ABI3Q9P2A46EBI-2811583,EBI-742038
HTTP428584EBI-2811583,EBI-466029
NUP54Q7Z3B44EBI-2811583,EBI-741048
NUP62P371985EBI-2811583,EBI-347978
TRAF1Q130777EBI-2811583,EBI-359224
UBQLN1Q9UMX0-23EBI-2811583,EBI-10173939

Protein-protein interaction databases

BioGridi115157. 48 interactors.
IntActiQ9BVL2. 33 interactors.
STRINGi9606.ENSP00000371155.

Structurei

Secondary structure

1599
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi345 – 371Combined sources27
Turni372 – 376Combined sources5
Helixi382 – 424Combined sources43

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4JO7X-ray1.75A/C/E/G341-428[»]
4JO9X-ray2.50B341-426[»]
4JQ5X-ray2.20A/B/C/D/E/F/G/H/I/J/K/L341-425[»]
5IJNelectron microscopy21.40G/M/S/Y1-599[»]
5IJOelectron microscopy21.40G/M/S/Y1-599[»]
ProteinModelPortaliQ9BVL2.
SMRiQ9BVL2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati7 – 812
Repeati30 – 3122
Repeati44 – 4532
Repeati63 – 6442
Repeati68 – 6952
Repeati488 – 48962
Repeati492 – 49372
Repeati513 – 51482
Repeati519 – 52092
Repeati529 – 530102
Repeati531 – 532112
Repeati545 – 546122
Repeati568 – 569132
Repeati578 – 579142

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni7 – 57914 X 2 AA repeats of F-GAdd BLAST573

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili256 – 276Sequence analysisAdd BLAST21
Coiled coili314 – 381Sequence analysisAdd BLAST68

Domaini

Contains FG repeats.

Sequence similaritiesi

Belongs to the NUP58 family.Curated

Keywords - Domaini

Coiled coil, Repeat

Phylogenomic databases

eggNOGiENOG410IIR3. Eukaryota.
ENOG410ZJAM. LUCA.
GeneTreeiENSGT00730000111111.
HOGENOMiHOG000273874.
HOVERGENiHBG052703.
InParanoidiQ9BVL2.
KOiK14307.
OMAiYRKTFLG.
OrthoDBiEOG091G0KUR.
PhylomeDBiQ9BVL2.
TreeFamiTF106502.

Family and domain databases

InterProiIPR024882. Nucleoporin_p58/p45.
[Graphical view]
PANTHERiPTHR13437. PTHR13437. 1 hit.

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9BVL2-1) [UniParc]FASTAAdd to basket
Also known as: p58

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSTGFSFGSG TLGSTTVAAG GTSTGGVFSF GTGASSNPSV GLNFGNLGST
60 70 80 90 100
STPATTSAPS SGFGTGLFGS KPATGFTLGG TNTGIATTIT TGLTLGTPAT
110 120 130 140 150
TSAATTGFSL GFNKPAASAT PFALPITSTS ASGLTLSSAL TSTPAASTGF
160 170 180 190 200
TLNNLGGTTA TTTTASTGLS LGGALAGLGG SLFQSTNTGT SGLGQNALGL
210 220 230 240 250
TLGTTAATST AGNEGLGGID FSSSSDKKSD KTGTRPEDSK ALKDENLPPV
260 270 280 290 300
ICQDVENLQK FVKEQKQVQE EISRMSSKAM LKVQEDIKAL KQLLSLAANG
310 320 330 340 350
IQRNTLNIDK LKIETAQELK NAEIALRTQK TPPGLQHEYA APADYFRILV
360 370 380 390 400
QQFEVQLQQY RQQIEELENH LATQANNSHI TPQDLSMAMQ KIYQTFVALA
410 420 430 440 450
AQLQSIHENV KVLKEQYLGY RKMFLGDAVD VFETRRAEAK KWQNTPRVTT
460 470 480 490 500
GPTPFSTMPN AAAVAMAATL TQQQQPATGP QPSLGVSFGT PFGSGIGTGL
510 520 530 540 550
QSSGLGSSNL GGFGTSSGFG CSTTGASTFG FGTTNKPSGS LSAGFGSSST
560 570 580 590
SGFNFSNPGI TASAGLTFGV SNPASAGFGT GGQLLQLKKP PAGNKRGKR
Length:599
Mass (Da):60,897
Last modified:June 1, 2001 - v1
Checksum:i2CC32E2A1B9E5132
GO
Isoform 2 (identifier: Q9BVL2-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     480-485: PQPSLG → LNAFKL
     486-599: Missing.

Show »
Length:485
Mass (Da):50,210
Checksum:iFC22003B927D904F
GO
Isoform 3 (identifier: Q9BVL2-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     84-95: Missing.

Note: No experimental confirmation available.
Show »
Length:587
Mass (Da):59,754
Checksum:i741B3A6CA2FAE06A
GO

Sequence cautioni

The sequence BAA23706 differs from that shown. Reason: Erroneous initiation.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_05057034A → T.1 PublicationCorresponds to variant rs12871898dbSNPEnsembl.1
Natural variantiVAR_050571166S → P.Corresponds to variant rs12871608dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_04565884 – 95Missing in isoform 3. 1 PublicationAdd BLAST12
Alternative sequenceiVSP_007946480 – 485PQPSLG → LNAFKL in isoform 2. 1 Publication6
Alternative sequenceiVSP_007947486 – 599Missing in isoform 2. 1 PublicationAdd BLAST114

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB007870 mRNA. Translation: BAA23706.2. Different initiation.
AK302946 mRNA. Translation: BAG64103.1.
AL138958, AL590787, AL646102 Genomic DNA. Translation: CAH71290.1.
AL590787, AL138958, AL646102 Genomic DNA. Translation: CAI39898.1.
AL590787 Genomic DNA. Translation: CAI39901.1.
AL646102, AL138958, AL590787 Genomic DNA. Translation: CAH72184.1.
BC001104 mRNA. Translation: AAH01104.1.
CCDSiCCDS31949.1. [Q9BVL2-3]
CCDS9314.1. [Q9BVL2-1]
RefSeqiNP_001008564.1. NM_001008564.1. [Q9BVL2-3]
NP_054808.1. NM_014089.3. [Q9BVL2-1]
UniGeneiHs.507537.
Hs.718943.
Hs.732064.

Genome annotation databases

EnsembliENST00000381718; ENSP00000371137; ENSG00000139496. [Q9BVL2-3]
ENST00000381736; ENSP00000371155; ENSG00000139496. [Q9BVL2-1]
ENST00000463407; ENSP00000418555; ENSG00000139496. [Q9BVL2-2]
GeneIDi9818.
KEGGihsa:9818.
UCSCiuc001uqg.2. human. [Q9BVL2-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB007870 mRNA. Translation: BAA23706.2. Different initiation.
AK302946 mRNA. Translation: BAG64103.1.
AL138958, AL590787, AL646102 Genomic DNA. Translation: CAH71290.1.
AL590787, AL138958, AL646102 Genomic DNA. Translation: CAI39898.1.
AL590787 Genomic DNA. Translation: CAI39901.1.
AL646102, AL138958, AL590787 Genomic DNA. Translation: CAH72184.1.
BC001104 mRNA. Translation: AAH01104.1.
CCDSiCCDS31949.1. [Q9BVL2-3]
CCDS9314.1. [Q9BVL2-1]
RefSeqiNP_001008564.1. NM_001008564.1. [Q9BVL2-3]
NP_054808.1. NM_014089.3. [Q9BVL2-1]
UniGeneiHs.507537.
Hs.718943.
Hs.732064.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4JO7X-ray1.75A/C/E/G341-428[»]
4JO9X-ray2.50B341-426[»]
4JQ5X-ray2.20A/B/C/D/E/F/G/H/I/J/K/L341-425[»]
5IJNelectron microscopy21.40G/M/S/Y1-599[»]
5IJOelectron microscopy21.40G/M/S/Y1-599[»]
ProteinModelPortaliQ9BVL2.
SMRiQ9BVL2.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi115157. 48 interactors.
IntActiQ9BVL2. 33 interactors.
STRINGi9606.ENSP00000371155.

Protein family/group databases

TCDBi1.I.1.1.3. the nuclear pore complex (npc) family.

PTM databases

iPTMnetiQ9BVL2.
PhosphoSitePlusiQ9BVL2.

Polymorphism and mutation databases

BioMutaiNUPL1.
DMDMi44888845.

Proteomic databases

EPDiQ9BVL2.
MaxQBiQ9BVL2.
PaxDbiQ9BVL2.
PeptideAtlasiQ9BVL2.
PRIDEiQ9BVL2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000381718; ENSP00000371137; ENSG00000139496. [Q9BVL2-3]
ENST00000381736; ENSP00000371155; ENSG00000139496. [Q9BVL2-1]
ENST00000463407; ENSP00000418555; ENSG00000139496. [Q9BVL2-2]
GeneIDi9818.
KEGGihsa:9818.
UCSCiuc001uqg.2. human. [Q9BVL2-1]

Organism-specific databases

CTDi9818.
GeneCardsiNUPL1.
HGNCiHGNC:20261. NUP58.
HPAiHPA039360.
MIMi607615. gene.
neXtProtiNX_Q9BVL2.
OpenTargetsiENSG00000139496.
PharmGKBiPA134981903.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IIR3. Eukaryota.
ENOG410ZJAM. LUCA.
GeneTreeiENSGT00730000111111.
HOGENOMiHOG000273874.
HOVERGENiHBG052703.
InParanoidiQ9BVL2.
KOiK14307.
OMAiYRKTFLG.
OrthoDBiEOG091G0KUR.
PhylomeDBiQ9BVL2.
TreeFamiTF106502.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000139496-MONOMER.
ReactomeiR-HSA-1169408. ISG15 antiviral mechanism.
R-HSA-159227. Transport of the SLBP independent Mature mRNA.
R-HSA-159230. Transport of the SLBP Dependant Mature mRNA.
R-HSA-159231. Transport of Mature mRNA Derived from an Intronless Transcript.
R-HSA-159236. Transport of Mature mRNA derived from an Intron-Containing Transcript.
R-HSA-165054. Rev-mediated nuclear export of HIV RNA.
R-HSA-168271. Transport of Ribonucleoproteins into the Host Nucleus.
R-HSA-168276. NS1 Mediated Effects on Host Pathways.
R-HSA-168325. Viral Messenger RNA Synthesis.
R-HSA-168333. NEP/NS2 Interacts with the Cellular Export Machinery.
R-HSA-170822. Regulation of Glucokinase by Glucokinase Regulatory Protein.
R-HSA-180746. Nuclear import of Rev protein.
R-HSA-180910. Vpr-mediated nuclear import of PICs.
R-HSA-191859. snRNP Assembly.
R-HSA-3108214. SUMOylation of DNA damage response and repair proteins.
R-HSA-3301854. Nuclear Pore Complex (NPC) Disassembly.
R-HSA-3371453. Regulation of HSF1-mediated heat shock response.
R-HSA-4570464. SUMOylation of RNA binding proteins.
R-HSA-4615885. SUMOylation of DNA replication proteins.
R-HSA-5578749. Transcriptional regulation by small RNAs.
R-HSA-6784531. tRNA processing in the nucleus.

Miscellaneous databases

ChiTaRSiNUPL1. human.
GeneWikiiNUPL1.
GenomeRNAii9818.
PROiQ9BVL2.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000139496.
CleanExiHS_NUPL1.
ExpressionAtlasiQ9BVL2. baseline and differential.
GenevisibleiQ9BVL2. HS.

Family and domain databases

InterProiIPR024882. Nucleoporin_p58/p45.
[Graphical view]
PANTHERiPTHR13437. PTHR13437. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiNUP58_HUMAN
AccessioniPrimary (citable) accession number: Q9BVL2
Secondary accession number(s): A6NI12
, B4DZJ1, O43160, Q5JRG2, Q5JRG5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 10, 2003
Last sequence update: June 1, 2001
Last modified: November 30, 2016
This is version 140 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Miscellaneous

In rat, the p62 complex contains two different isoforms of NUP58. Isoform p45 has however not been isolated in human so far.

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 13
    Human chromosome 13: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.