Reviewed, UniProtKB/Swiss-Prot Q9BVK8 (TM147_HUMAN)

Names and origin

Protein names

Recommended name:
    Transmembrane protein 147
Alternative name(s):
    Protein NIFIE 14

Gene names

Name:

TMEM147

Organism

Homo sapiens (Human) [Complete proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	224 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

General annotation (Comments)

Subcellular location

Membrane; Multi-pass membrane protein Potential.

Ontologies

Keywords
Cellular component	Membrane
Coding sequence diversity	Polymorphism
Domain	Transmembrane
Technical term	Complete proteome
Gene Ontology (GO)
Cellular component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	protein binding Inferred from physical interaction. Source: IntAct
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
BAT5	O95870	1	EBI-348587,EBI-348517

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 224	224	Transmembrane protein 147		PRO_0000271701
Regions
	Transmembrane	1 – 21	21	Potential
	Transmembrane	38 – 58	21	Potential
	Transmembrane	99 – 119	21	Potential
	Transmembrane	137 – 157	21	Potential
	Transmembrane	167 – 187	21	Potential
	Transmembrane	202 – 222	21	Potential
Natural variations
	Natural variant	132	1	Y → H: dbSNP rs1269215.		VAR_051429
Experimental info
	Sequence conflict	24 – 25	2	SG → TD in CAA77013. Ref.1
	Sequence conflict	144 – 145	2	VH → GP in CAA77013. Ref.1
	Sequence conflict	176	1	S → R in CAA77013. Ref.1
	Sequence conflict	197 – 205	9	ALLARAVVT → VLMAGVVVK in CAA77013. Ref.1
	Sequence conflict	209 – 215	7	ALSTLAL → VIRNLAM in CAA77013. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	Q9BVK8-1 [UniParc]. Last modified June 1, 2001. Version 1. Checksum: 90122F32C34F16AE	FASTA	224	25,261
	10 20 30 40 50 60 MTLFHFGNCF ALAYFPYFIT YKCSGLSEYN AFWKCVQAGV TYLFVQLCKM LFLATFFPTW 70 80 90 100 110 120 EGGIYDFIGE FMKASVDVAD LIGLNLVMSR NAGKGEYKIM VAALGWATAE LIMSRCIPLW 130 140 150 160 170 180 VGARGIEFDW KYIQMSIDSN ISLVHYIVAS AQVWMITRYD LYHTFRPAVL LLMFLSVYKA 190 200 210 220 FVMETFVHLC SLGSWAALLA RAVVTGLLAL STLALYVAVV NVHS

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Cloning of a novel putative seven transmembrane domain protein from human lingual tissue." Daniell S.J., Perry B.N., Connerton I.F. Submitted (AUG-1998) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Tongue epithelium.
[2]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Ovary.

Cross-references

Sequence databases
EMBLGenBankDDBJ	Y18007 mRNA. Translation: CAA77013.1. BC001118 mRNA. Translation: AAH01118.1.
IPI	IPI00013293.
RefSeq	NP_116024.1.
UniGene	Hs.9234
3D structure databases
ModBase	Search...
Protein-protein interaction databases
IntAct	Q9BVK8. 4 interactions.
STRING	Q9BVK8.
Proteomic databases
PRIDE	Q9BVK8.
Genome annotation databases
Ensembl	ENST00000222284; ENSP00000222284; ENSG00000105677; Homo sapiens. [Genome view]
GeneID	10430.
KEGG	hsa:10430.
UCSC	uc002oaj.1. human.
Organism-specific databases
CTD	10430.
GeneCards	GC19P040729.
HGNC	HGNC:30414. TMEM147.
GenAtlas	Search...
Phylogenomic databases
HOGENOM	HBG315506.
HOVERGEN	Q9BVK8.
InParanoid	Q9BVK8.
OMA	GINEYSS.
Gene expression databases
ArrayExpress	Q9BVK8.
Bgee	Q9BVK8.
CleanEx	HS_TMEM147.
Genevestigator	Q9BVK8.
Family and domain databases
InterPro	IPR019164. DUF2053_membrane. [Graphical view]
Pfam	PF09767. DUF2053. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	39532.

Entry information

Entry name

TM147_HUMAN

Accession

Primary (citable) accession number: Q9BVK8
Secondary accession number(s): O75790

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 9, 2007
Last sequence update:	June 1, 2001
Last modified:	December 15, 2009
This is version 45 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.