UniProtKB - Q9BVK6 (TMED9_HUMAN)
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Protein
Transmembrane emp24 domain-containing protein 9
Gene
TMED9
Organism
Homo sapiens (Human)
Status
Functioni
Appears to be involved in vesicular protein trafficking, mainly in the early secretory pathway. In COPI vesicle-mediated retrograde transport involved in the coatomer recruitment to membranes of the early secretory pathway. Increases coatomer-dependent activity of ARFGAP2. Thought to play a crucial role in the specific retention of p24 complexes in cis-Golgi membranes; specifically contributes to the coupled localization of TMED2 and TMED10 in the cis-Golgi network. May be involved in organization of intracellular membranes, such as of the ER-Golgi intermediate compartment and the Golgi apparatus. Involved in ER localization of PTPN2 isoform PTPB.5 Publications
GO - Molecular functioni
- syntaxin binding Source: UniProtKB
GO - Biological processi
- COPI coating of Golgi vesicle Source: UniProtKB
- ER to Golgi vesicle-mediated transport Source: Reactome
- Golgi organization Source: UniProtKB
- positive regulation of organelle organization Source: UniProtKB
- protein transport Source: UniProtKB-KW
- retrograde vesicle-mediated transport, Golgi to ER Source: Reactome
Keywordsi
Biological process | Protein transport, Transport |
Enzyme and pathway databases
Reactomei | R-HSA-6807878. COPI-mediated anterograde transport. R-HSA-6811434. COPI-dependent Golgi-to-ER retrograde traffic. |
Names & Taxonomyi
Protein namesi | Recommended name: Transmembrane emp24 domain-containing protein 9Alternative name(s): GMP25 Glycoprotein 25L2 p24 family protein alpha-2 Short name: p24alpha2 p25 |
Gene namesi | Name:TMED9 Synonyms:GP25L2 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000184840.11. |
HGNCi | HGNC:24878. TMED9. |
neXtProti | NX_Q9BVK6. |
Subcellular locationi
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 38 – 202 | LumenalSequence analysisAdd BLAST | 165 | |
Transmembranei | 203 – 222 | HelicalSequence analysisAdd BLAST | 20 | |
Topological domaini | 223 – 235 | CytoplasmicSequence analysisAdd BLAST | 13 |
Keywords - Cellular componenti
Endoplasmic reticulum, Golgi apparatus, MembranePathology & Biotechi
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 232 – 233 | KK → SS: Localization to plasma membrane and endocytosis. 1 Publication | 2 |
Organism-specific databases
DisGeNETi | 54732. |
OpenTargetsi | ENSG00000184840. |
PharmGKBi | PA134881976. |
Polymorphism and mutation databases
BioMutai | TMED9. |
DMDMi | 239938724. |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 37 | By similarityAdd BLAST | 37 | |
ChainiPRO_0000010396 | 38 – 235 | Transmembrane emp24 domain-containing protein 9Add BLAST | 198 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 125 | N-linked (GlcNAc...) asparagine2 Publications | 1 | |
Modified residuei | 160 | N6-acetyllysineBy similarity | 1 |
Post-translational modificationi
N-linked glycosylated containing high mannose.3 Publications
Keywords - PTMi
Acetylation, GlycoproteinProteomic databases
EPDi | Q9BVK6. |
MaxQBi | Q9BVK6. |
PaxDbi | Q9BVK6. |
PeptideAtlasi | Q9BVK6. |
PRIDEi | Q9BVK6. |
TopDownProteomicsi | Q9BVK6. |
PTM databases
iPTMneti | Q9BVK6. |
PhosphoSitePlusi | Q9BVK6. |
SwissPalmi | Q9BVK6. |
Expressioni
Gene expression databases
Bgeei | ENSG00000184840. |
CleanExi | HS_TMED9. |
ExpressionAtlasi | Q9BVK6. baseline and differential. |
Genevisiblei | Q9BVK6. HS. |
Organism-specific databases
HPAi | HPA014650. |
Interactioni
Subunit structurei
Monomer and homodimer in endoplasmic reticulum. Predominantly monomeric and to lesser extent homodimeric in endoplasmic reticulum-Golgi intermediate compartment and cis-Golgi network. Probably oligomerizes with other members of the EMP24/GP25L family such as TMED2, TMED7 and TMED10. Interacts with TMED5. Interacts (via C-terminus) with COPG1; the interaction involves dimeric TMED9. Interacts with PTPN2 and SPAST. Interacts with STX17; the interaction is direct.7 Publications
Binary interactionsi
With | Entry | #Exp. | IntAct | Notes |
---|---|---|---|---|
PTPN2 | P17706-1 | 5 | EBI-1056827,EBI-4409481 |
GO - Molecular functioni
- syntaxin binding Source: UniProtKB
Protein-protein interaction databases
BioGridi | 120115. 60 interactors. |
ELMi | Q9BVK6. |
IntActi | Q9BVK6. 28 interactors. |
MINTi | Q9BVK6. |
STRINGi | 9606.ENSP00000330945. |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 47 – 145 | GOLDPROSITE-ProRule annotationAdd BLAST | 99 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 121 – 160 | Required for interaction with STX171 PublicationAdd BLAST | 40 |
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 154 – 184 | Sequence analysisAdd BLAST | 31 |
Motif
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Motifi | 228 – 235 | COPI vesicle coat-bindingSequence analysis | 8 | |
Motifi | 228 – 229 | COPII vesicle coat-bindingSequence analysis | 2 |
Sequence similaritiesi
Belongs to the EMP24/GP25L family.Curated
Keywords - Domaini
Coiled coil, Signal, Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG1690. Eukaryota. ENOG410XPUW. LUCA. |
GeneTreei | ENSGT00430000030848. |
HOGENOMi | HOG000160228. |
HOVERGENi | HBG105357. |
InParanoidi | Q9BVK6. |
KOi | K20346. |
OMAi | VLWWSIV. |
OrthoDBi | EOG091G0JDW. |
PhylomeDBi | Q9BVK6. |
TreeFami | TF314123. |
Family and domain databases
InterProi | View protein in InterPro IPR009038. GOLD_dom. IPR015720. TMP21-related. |
PANTHERi | PTHR22811. PTHR22811. 1 hit. |
Pfami | View protein in Pfam PF01105. EMP24_GP25L. 1 hit. |
SMARTi | View protein in SMART SM01190. EMP24_GP25L. 1 hit. |
PROSITEi | View protein in PROSITE PS50866. GOLD. 1 hit. |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
Q9BVK6-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MAVELGVLLV RPRPGTGLGR VMRTLLLVLW LATRGSALYF HIGETEKKCF
60 70 80 90 100
IEEIPDETMV IGNYRTQLYD KQREEYQPAT PGLGMFVEVK DPEDKVILAR
110 120 130 140 150
QYGSEGRFTF TSHTPGEHQI CLHSNSTKFS LFAGGMLRVH LDIQVGEHAN
160 170 180 190 200
DYAEIAAKDK LSELQLRVRQ LVEQVEQIQK EQNYQRWREE RFRQTSESTN
210 220 230
QRVLWWSILQ TLILVAIGVW QMRHLKSFFE AKKLV
Sequence cautioni
The sequence AAL35268 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence CAA62380 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 83 | L → F in CAA62380 (PubMed:15489334).Curated | 1 | |
Sequence conflicti | 86 | F → C in CAA62380 (PubMed:15489334).Curated | 1 | |
Sequence conflicti | 101 | Q → E in CAA62380 (PubMed:15489334).Curated | 1 | |
Sequence conflicti | 102 | Y → C in AAL35268 (Ref. 3) Curated | 1 | |
Sequence conflicti | 156 | A → P in CAA62380 (PubMed:15489334).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_061178 | 16 | T → S. Corresponds to variant dbSNP:rs57960711Ensembl. | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC139795 Genomic DNA. No translation available. BC001123 mRNA. Translation: AAH01123.2. X90872 mRNA. Translation: CAA62380.1. Different initiation. AF441399 mRNA. Translation: AAL35268.1. Different initiation. |
CCDSi | CCDS4428.1. |
RefSeqi | NP_059980.2. NM_017510.5. |
UniGenei | Hs.279929. |
Genome annotation databases
Ensembli | ENST00000332598; ENSP00000330945; ENSG00000184840. |
GeneIDi | 54732. |
KEGGi | hsa:54732. |
UCSCi | uc003mhx.4. human. |
Keywords - Coding sequence diversityi
PolymorphismSimilar proteinsi
Entry informationi
Entry namei | TMED9_HUMAN | |
Accessioni | Q9BVK6Primary (citable) accession number: Q9BVK6 Secondary accession number(s): Q14437, Q8WZ61 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 10, 2003 |
Last sequence update: | June 16, 2009 | |
Last modified: | March 28, 2018 | |
This is version 142 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |