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Protein

U3 small nucleolar RNA-associated protein 14 homolog A

Gene

UTP14A

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

May be required for ribosome biogenesis.By similarity

GO - Molecular functioni

  • poly(A) RNA binding Source: UniProtKB

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Ribosome biogenesis

Enzyme and pathway databases

BioCyciZFISH:ENSG00000156697-MONOMER.
ReactomeiR-HSA-6790901. rRNA modification in the nucleus and cytosol.
R-HSA-6791226. Major pathway of rRNA processing in the nucleolus and cytosol.

Names & Taxonomyi

Protein namesi
Recommended name:
U3 small nucleolar RNA-associated protein 14 homolog A
Alternative name(s):
Antigen NY-CO-16
Serologically defined colon cancer antigen 16
Gene namesi
Name:UTP14A
Synonyms:SDCCAG16
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome X

Organism-specific databases

HGNCiHGNC:10665. UTP14A.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000156697.
PharmGKBiPA35595.

Polymorphism and mutation databases

BioMutaiUTP14A.
DMDMi68566226.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000657331 – 771U3 small nucleolar RNA-associated protein 14 homolog AAdd BLAST771

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei29PhosphoserineCombined sources1
Modified residuei31PhosphoserineCombined sources1
Modified residuei52PhosphoserineCombined sources1
Modified residuei77PhosphoserineCombined sources1
Modified residuei81PhosphoserineCombined sources1
Modified residuei205PhosphothreonineCombined sources1
Modified residuei405PhosphoserineCombined sources1
Modified residuei407PhosphoserineCombined sources1
Modified residuei433CitrullineBy similarity1
Modified residuei437PhosphoserineCombined sources1
Modified residuei445PhosphoserineCombined sources1
Modified residuei453PhosphoserineCombined sources1
Modified residuei569PhosphoserineCombined sources1
Modified residuei589CitrullineBy similarity1
Cross-linki733Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources

Post-translational modificationi

Citrullinated by PADI4.By similarity

Keywords - PTMi

Citrullination, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiQ9BVJ6.
MaxQBiQ9BVJ6.
PaxDbiQ9BVJ6.
PeptideAtlasiQ9BVJ6.
PRIDEiQ9BVJ6.

2D gel databases

SWISS-2DPAGEQ9BVJ6.

PTM databases

iPTMnetiQ9BVJ6.
PhosphoSitePlusiQ9BVJ6.

Expressioni

Tissue specificityi

Ubiquitously expressed.1 Publication

Gene expression databases

BgeeiENSG00000156697.
CleanExiHS_UTP14A.
ExpressionAtlasiQ9BVJ6. baseline and differential.
GenevisibleiQ9BVJ6. HS.

Organism-specific databases

HPAiHPA047217.
HPA054023.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
GADD45GO952573EBI-473284,EBI-448202

Protein-protein interaction databases

BioGridi116026. 106 interactors.
DIPiDIP-32505N.
IntActiQ9BVJ6. 50 interactors.
MINTiMINT-1396425.
STRINGi9606.ENSP00000377944.

Structurei

3D structure databases

ProteinModelPortaliQ9BVJ6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili40 – 67Sequence analysisAdd BLAST28
Coiled coili216 – 290Sequence analysisAdd BLAST75
Coiled coili317 – 347Sequence analysisAdd BLAST31

Sequence similaritiesi

Belongs to the UTP14 family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG2172. Eukaryota.
COG5644. LUCA.
GeneTreeiENSGT00390000008142.
HOGENOMiHOG000231396.
HOVERGENiHBG056550.
InParanoidiQ9BVJ6.
KOiK14567.
OMAiRTAWDEE.
OrthoDBiEOG091G0DC1.
PhylomeDBiQ9BVJ6.
TreeFamiTF314531.

Family and domain databases

InterProiIPR006709. SSU_processome_Utp14.
[Graphical view]
PANTHERiPTHR14150. PTHR14150. 1 hit.
PfamiPF04615. Utp14. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9BVJ6-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MTANRLAESL LALSQQEELA DLPKDYLLSE SEDEGDNDGE RKHQKLLEAI
60 70 80 90 100
SSLDGKNRRK LAERSEASLK VSEFNVSSEG SGEKLVLADL LEPVKTSSSL
110 120 130 140 150
ATVKKQLSRV KSKKTVELPL NKEEIERIHR EVAFNKTAQV LSKWDPVVLK
160 170 180 190 200
NRQAEQLVFP LEKEEPAIAP IEHVLSGWKA RTPLEQEIFN LLHKNKQPVT
210 220 230 240 250
DPLLTPVEKA SLRAMSLEEA KMRRAELQRA RALQSYYEAK ARREKKIKSK
260 270 280 290 300
KYHKVVKKGK AKKALKEFEQ LRKVNPAAAL EELEKIEKAR MMERMSLKHQ
310 320 330 340 350
NSGKWAKSKA IMAKYDLEAR QAMQEQLSKN KELTQKLQVA SESEEEEGGT
360 370 380 390 400
EDVEELLVPD VVNEVQMNAD GPNPWMLRSC TSDTKEAATQ EDPEQLPELE
410 420 430 440 450
AHGVSESEGE ERPVAEEEIL LREFEERRSL RKRSELSQDA EPAGSQETKD
460 470 480 490 500
SGSQEVLSEL RVLSQKLKEN HQSRKQKASS EGTIPQVQRE EPAPEEEEPL
510 520 530 540 550
LLQRPERVQT LEELEELGKE ECFQNKELPR PVLEGQQSER TPNNRPDAPK
560 570 580 590 600
EKKKKEQMID LQNLLTTQSP SVKSLAVPTI EELEDEEERN HRQMIKEAFA
610 620 630 640 650
GDDVIRDFLK EKREAVEASK PKDVDLTLPG WGEWGGVGLK PSAKKRRRFL
660 670 680 690 700
IKAPEGPPRK DKNLPNVIIN EKRNIHAAAH QVRVLPYPFT HHWQFERTIQ
710 720 730 740 750
TPIGSTWNTQ RAFQKLTTPK VVTKPGHIIN PIKAEDVGYR SSSRSDLSVI
760 770
QRNPKRITTR HKKQLKKCSV D
Length:771
Mass (Da):87,978
Last modified:June 1, 2001 - v1
Checksum:iDF82C264BA6486FE
GO
Isoform 2 (identifier: Q9BVJ6-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-12: MTANRLAESLLA → MKGDFRKKKSEA
     13-180: Missing.

Note: Gene prediction based on EST data. No experimental confirmation available.
Show »
Length:603
Mass (Da):69,264
Checksum:iEA095325D8028787
GO
Isoform 3 (identifier: Q9BVJ6-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     128-179: Missing.

Note: No experimental confirmation available.
Show »
Length:719
Mass (Da):82,005
Checksum:i8555F377424722C1
GO

Sequence cautioni

The sequence CAI42909 differs from that shown. Reason: Erroneous gene model prediction.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_022811487V → A.Corresponds to variant rs2281278dbSNPEnsembl.1
Natural variantiVAR_069181771D → G.1 PublicationCorresponds to variant rs1055032dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0144751 – 12MTANR…ESLLA → MKGDFRKKKSEA in isoform 2. CuratedAdd BLAST12
Alternative sequenceiVSP_01447613 – 180Missing in isoform 2. CuratedAdd BLAST168
Alternative sequenceiVSP_046389128 – 179Missing in isoform 3. 1 PublicationAdd BLAST52

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK291918 mRNA. Translation: BAF84607.1.
AK298578 mRNA. Translation: BAG60770.1.
AL034405 Genomic DNA. Translation: CAI42908.1.
AL034405 Genomic DNA. Translation: CAI42909.1. Sequence problems.
CH471107 Genomic DNA. Translation: EAX11820.1.
BC001149 mRNA. Translation: AAH01149.1.
BC009649 mRNA. Translation: AAH09649.1.
BC014987 mRNA. Translation: AAH14987.1.
CCDSiCCDS14615.1. [Q9BVJ6-1]
CCDS55489.1. [Q9BVJ6-3]
RefSeqiNP_001159693.1. NM_001166221.1. [Q9BVJ6-3]
NP_006640.2. NM_006649.3. [Q9BVJ6-1]
UniGeneiHs.458598.

Genome annotation databases

EnsembliENST00000394422; ENSP00000377944; ENSG00000156697. [Q9BVJ6-1]
ENST00000425117; ENSP00000388669; ENSG00000156697. [Q9BVJ6-3]
GeneIDi10813.
KEGGihsa:10813.
UCSCiuc004euz.4. human. [Q9BVJ6-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK291918 mRNA. Translation: BAF84607.1.
AK298578 mRNA. Translation: BAG60770.1.
AL034405 Genomic DNA. Translation: CAI42908.1.
AL034405 Genomic DNA. Translation: CAI42909.1. Sequence problems.
CH471107 Genomic DNA. Translation: EAX11820.1.
BC001149 mRNA. Translation: AAH01149.1.
BC009649 mRNA. Translation: AAH09649.1.
BC014987 mRNA. Translation: AAH14987.1.
CCDSiCCDS14615.1. [Q9BVJ6-1]
CCDS55489.1. [Q9BVJ6-3]
RefSeqiNP_001159693.1. NM_001166221.1. [Q9BVJ6-3]
NP_006640.2. NM_006649.3. [Q9BVJ6-1]
UniGeneiHs.458598.

3D structure databases

ProteinModelPortaliQ9BVJ6.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi116026. 106 interactors.
DIPiDIP-32505N.
IntActiQ9BVJ6. 50 interactors.
MINTiMINT-1396425.
STRINGi9606.ENSP00000377944.

PTM databases

iPTMnetiQ9BVJ6.
PhosphoSitePlusiQ9BVJ6.

Polymorphism and mutation databases

BioMutaiUTP14A.
DMDMi68566226.

2D gel databases

SWISS-2DPAGEQ9BVJ6.

Proteomic databases

EPDiQ9BVJ6.
MaxQBiQ9BVJ6.
PaxDbiQ9BVJ6.
PeptideAtlasiQ9BVJ6.
PRIDEiQ9BVJ6.

Protocols and materials databases

DNASUi10813.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000394422; ENSP00000377944; ENSG00000156697. [Q9BVJ6-1]
ENST00000425117; ENSP00000388669; ENSG00000156697. [Q9BVJ6-3]
GeneIDi10813.
KEGGihsa:10813.
UCSCiuc004euz.4. human. [Q9BVJ6-1]

Organism-specific databases

CTDi10813.
GeneCardsiUTP14A.
HGNCiHGNC:10665. UTP14A.
HPAiHPA047217.
HPA054023.
MIMi300508. gene.
neXtProtiNX_Q9BVJ6.
OpenTargetsiENSG00000156697.
PharmGKBiPA35595.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2172. Eukaryota.
COG5644. LUCA.
GeneTreeiENSGT00390000008142.
HOGENOMiHOG000231396.
HOVERGENiHBG056550.
InParanoidiQ9BVJ6.
KOiK14567.
OMAiRTAWDEE.
OrthoDBiEOG091G0DC1.
PhylomeDBiQ9BVJ6.
TreeFamiTF314531.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000156697-MONOMER.
ReactomeiR-HSA-6790901. rRNA modification in the nucleus and cytosol.
R-HSA-6791226. Major pathway of rRNA processing in the nucleolus and cytosol.

Miscellaneous databases

ChiTaRSiUTP14A. human.
GeneWikiiUTP14A.
GenomeRNAii10813.
PROiQ9BVJ6.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000156697.
CleanExiHS_UTP14A.
ExpressionAtlasiQ9BVJ6. baseline and differential.
GenevisibleiQ9BVJ6. HS.

Family and domain databases

InterProiIPR006709. SSU_processome_Utp14.
[Graphical view]
PANTHERiPTHR14150. PTHR14150. 1 hit.
PfamiPF04615. Utp14. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiUT14A_HUMAN
AccessioniPrimary (citable) accession number: Q9BVJ6
Secondary accession number(s): A8K7A3
, A8MVQ1, B4DQ08, E9PEL7, Q5JYF1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 5, 2005
Last sequence update: June 1, 2001
Last modified: November 2, 2016
This is version 135 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Miscellaneous

The human genome also contains the UTP14C gene, an autosomal retrotransposed copy of this X-linked gene. Evolution of autosomal retrogenes from X-linked progenitors compensates for X-chromosome silencing during male meiosis.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.