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Protein

U3 small nucleolar RNA-associated protein 14 homolog A

Gene

UTP14A

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May be required for ribosome biogenesis.By similarity

Miscellaneous

The human genome also contains the UTP14C gene, an autosomal retrotransposed copy of this X-linked gene. Evolution of autosomal retrogenes from X-linked progenitors compensates for X-chromosome silencing during male meiosis.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processRibosome biogenesis

Enzyme and pathway databases

ReactomeiR-HSA-6790901 rRNA modification in the nucleus and cytosol
R-HSA-6791226 Major pathway of rRNA processing in the nucleolus and cytosol

Names & Taxonomyi

Protein namesi
Recommended name:
U3 small nucleolar RNA-associated protein 14 homolog A
Alternative name(s):
Antigen NY-CO-16
Serologically defined colon cancer antigen 16
Gene namesi
Name:UTP14A
Synonyms:SDCCAG16
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome X

Organism-specific databases

EuPathDBiHostDB:ENSG00000156697.12
HGNCiHGNC:10665 UTP14A
MIMi300508 gene
neXtProtiNX_Q9BVJ6

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000156697
PharmGKBiPA35595

Polymorphism and mutation databases

BioMutaiUTP14A
DMDMi68566226

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000657331 – 771U3 small nucleolar RNA-associated protein 14 homolog AAdd BLAST771

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei29PhosphoserineCombined sources1
Modified residuei31PhosphoserineCombined sources1
Modified residuei52PhosphoserineCombined sources1
Modified residuei77PhosphoserineCombined sources1
Modified residuei81PhosphoserineCombined sources1
Cross-linki122Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei205PhosphothreonineCombined sources1
Modified residuei405PhosphoserineCombined sources1
Modified residuei407PhosphoserineCombined sources1
Modified residuei433CitrullineBy similarity1
Modified residuei437PhosphoserineCombined sources1
Modified residuei445PhosphoserineCombined sources1
Cross-linki449Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei453PhosphoserineCombined sources1
Cross-linki519Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei569PhosphoserineCombined sources1
Modified residuei589CitrullineBy similarity1
Cross-linki733Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources

Post-translational modificationi

Citrullinated by PADI4.By similarity

Keywords - PTMi

Citrullination, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiQ9BVJ6
MaxQBiQ9BVJ6
PaxDbiQ9BVJ6
PeptideAtlasiQ9BVJ6
PRIDEiQ9BVJ6

2D gel databases

SWISS-2DPAGEQ9BVJ6

PTM databases

iPTMnetiQ9BVJ6
PhosphoSitePlusiQ9BVJ6

Expressioni

Tissue specificityi

Ubiquitously expressed.1 Publication

Gene expression databases

BgeeiENSG00000156697
CleanExiHS_UTP14A
ExpressionAtlasiQ9BVJ6 baseline and differential
GenevisibleiQ9BVJ6 HS

Organism-specific databases

HPAiHPA047217
HPA054023

Interactioni

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi116026, 110 interactors
DIPiDIP-32505N
IntActiQ9BVJ6, 52 interactors
MINTiQ9BVJ6
STRINGi9606.ENSP00000377944

Structurei

3D structure databases

ProteinModelPortaliQ9BVJ6
SMRiQ9BVJ6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili40 – 67Sequence analysisAdd BLAST28
Coiled coili216 – 290Sequence analysisAdd BLAST75
Coiled coili317 – 347Sequence analysisAdd BLAST31

Sequence similaritiesi

Belongs to the UTP14 family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG2172 Eukaryota
COG5644 LUCA
GeneTreeiENSGT00390000008142
HOGENOMiHOG000231396
HOVERGENiHBG056550
InParanoidiQ9BVJ6
KOiK14567
OMAiTTLPGWG
OrthoDBiEOG091G0DC1
PhylomeDBiQ9BVJ6
TreeFamiTF314531

Family and domain databases

InterProiView protein in InterPro
IPR006709 SSU_processome_Utp14
PANTHERiPTHR14150 PTHR14150, 1 hit
PfamiView protein in Pfam
PF04615 Utp14, 1 hit

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9BVJ6-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MTANRLAESL LALSQQEELA DLPKDYLLSE SEDEGDNDGE RKHQKLLEAI
60 70 80 90 100
SSLDGKNRRK LAERSEASLK VSEFNVSSEG SGEKLVLADL LEPVKTSSSL
110 120 130 140 150
ATVKKQLSRV KSKKTVELPL NKEEIERIHR EVAFNKTAQV LSKWDPVVLK
160 170 180 190 200
NRQAEQLVFP LEKEEPAIAP IEHVLSGWKA RTPLEQEIFN LLHKNKQPVT
210 220 230 240 250
DPLLTPVEKA SLRAMSLEEA KMRRAELQRA RALQSYYEAK ARREKKIKSK
260 270 280 290 300
KYHKVVKKGK AKKALKEFEQ LRKVNPAAAL EELEKIEKAR MMERMSLKHQ
310 320 330 340 350
NSGKWAKSKA IMAKYDLEAR QAMQEQLSKN KELTQKLQVA SESEEEEGGT
360 370 380 390 400
EDVEELLVPD VVNEVQMNAD GPNPWMLRSC TSDTKEAATQ EDPEQLPELE
410 420 430 440 450
AHGVSESEGE ERPVAEEEIL LREFEERRSL RKRSELSQDA EPAGSQETKD
460 470 480 490 500
SGSQEVLSEL RVLSQKLKEN HQSRKQKASS EGTIPQVQRE EPAPEEEEPL
510 520 530 540 550
LLQRPERVQT LEELEELGKE ECFQNKELPR PVLEGQQSER TPNNRPDAPK
560 570 580 590 600
EKKKKEQMID LQNLLTTQSP SVKSLAVPTI EELEDEEERN HRQMIKEAFA
610 620 630 640 650
GDDVIRDFLK EKREAVEASK PKDVDLTLPG WGEWGGVGLK PSAKKRRRFL
660 670 680 690 700
IKAPEGPPRK DKNLPNVIIN EKRNIHAAAH QVRVLPYPFT HHWQFERTIQ
710 720 730 740 750
TPIGSTWNTQ RAFQKLTTPK VVTKPGHIIN PIKAEDVGYR SSSRSDLSVI
760 770
QRNPKRITTR HKKQLKKCSV D
Length:771
Mass (Da):87,978
Last modified:June 1, 2001 - v1
Checksum:iDF82C264BA6486FE
GO
Isoform 2 (identifier: Q9BVJ6-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-12: MTANRLAESLLA → MKGDFRKKKSEA
     13-180: Missing.

Note: Gene prediction based on EST data. No experimental confirmation available.
Show »
Length:603
Mass (Da):69,264
Checksum:iEA095325D8028787
GO
Isoform 3 (identifier: Q9BVJ6-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     128-179: Missing.

Note: No experimental confirmation available.
Show »
Length:719
Mass (Da):82,005
Checksum:i8555F377424722C1
GO

Sequence cautioni

The sequence CAI42909 differs from that shown. Reason: Erroneous gene model prediction.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_078693120Missing 1 Publication1
Natural variantiVAR_022811487V → A. Corresponds to variant dbSNP:rs2281278Ensembl.1
Natural variantiVAR_069181771D → G1 PublicationCorresponds to variant dbSNP:rs1055032Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0144751 – 12MTANR…ESLLA → MKGDFRKKKSEA in isoform 2. CuratedAdd BLAST12
Alternative sequenceiVSP_01447613 – 180Missing in isoform 2. CuratedAdd BLAST168
Alternative sequenceiVSP_046389128 – 179Missing in isoform 3. 1 PublicationAdd BLAST52

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK291918 mRNA Translation: BAF84607.1
AK298578 mRNA Translation: BAG60770.1
AL034405 Genomic DNA Translation: CAI42908.1
AL034405 Genomic DNA Translation: CAI42909.1 Sequence problems.
CH471107 Genomic DNA Translation: EAX11820.1
BC001149 mRNA Translation: AAH01149.1
BC009649 mRNA Translation: AAH09649.1
BC014987 mRNA Translation: AAH14987.1
CCDSiCCDS14615.1 [Q9BVJ6-1]
CCDS55489.1 [Q9BVJ6-3]
RefSeqiNP_001159693.1, NM_001166221.1 [Q9BVJ6-3]
NP_006640.2, NM_006649.3 [Q9BVJ6-1]
UniGeneiHs.458598

Genome annotation databases

EnsembliENST00000394422; ENSP00000377944; ENSG00000156697 [Q9BVJ6-1]
ENST00000425117; ENSP00000388669; ENSG00000156697 [Q9BVJ6-3]
GeneIDi10813
KEGGihsa:10813
UCSCiuc004euz.4 human [Q9BVJ6-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiUT14A_HUMAN
AccessioniPrimary (citable) accession number: Q9BVJ6
Secondary accession number(s): A8K7A3
, A8MVQ1, B4DQ08, E9PEL7, Q5JYF1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 5, 2005
Last sequence update: June 1, 2001
Last modified: May 23, 2018
This is version 144 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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