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Protein

Nucleolar complex protein 4 homolog

Gene

NOC4L

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  • RNA binding Source: UniProtKB

GO - Biological processi

Enzyme and pathway databases

ReactomeiR-HSA-6790901. rRNA modification in the nucleus and cytosol.
R-HSA-6791226. Major pathway of rRNA processing in the nucleolus and cytosol.

Names & Taxonomyi

Protein namesi
Recommended name:
Nucleolar complex protein 4 homolog
Short name:
NOC4 protein homolog
Alternative name(s):
NOC4-like protein
Nucleolar complex-associated protein 4-like protein
Gene namesi
Name:NOC4L
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 12

Organism-specific databases

EuPathDBiHostDB:ENSG00000184967.6.
HGNCiHGNC:28461. NOC4L.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei297 – 317HelicalSequence analysisAdd BLAST21
Transmembranei347 – 367HelicalSequence analysisAdd BLAST21
Transmembranei375 – 395HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Membrane, Nucleus

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000184967.
PharmGKBiPA142671262.

Polymorphism and mutation databases

BioMutaiNOC4L.
DMDMi73621312.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001734841 – 516Nucleolar complex protein 4 homologAdd BLAST516

Proteomic databases

EPDiQ9BVI4.
MaxQBiQ9BVI4.
PaxDbiQ9BVI4.
PeptideAtlasiQ9BVI4.
PRIDEiQ9BVI4.

2D gel databases

SWISS-2DPAGEiQ9BVI4.

PTM databases

iPTMnetiQ9BVI4.
PhosphoSitePlusiQ9BVI4.
SwissPalmiQ9BVI4.

Expressioni

Gene expression databases

BgeeiENSG00000184967.
CleanExiHS_NOC4L.
ExpressionAtlasiQ9BVI4. baseline and differential.
GenevisibleiQ9BVI4. HS.

Organism-specific databases

HPAiHPA053424.

Interactioni

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi122508. 58 interactors.
DIPiDIP-32938N.
IntActiQ9BVI4. 29 interactors.
MINTiMINT-1432575.
STRINGi9606.ENSP00000328854.

Structurei

3D structure databases

ProteinModelPortaliQ9BVI4.
SMRiQ9BVI4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the CBF/MAK21 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG2154. Eukaryota.
ENOG410YJPG. LUCA.
GeneTreeiENSGT00390000016776.
HOGENOMiHOG000158314.
HOVERGENiHBG060855.
InParanoidiQ9BVI4.
KOiK14771.
OMAiMQKQNIT.
OrthoDBiEOG091G07EE.
PhylomeDBiQ9BVI4.
TreeFamiTF105812.

Family and domain databases

Gene3Di1.25.10.10. 1 hit.
InterProiView protein in InterPro
IPR011989. ARM-like.
IPR016024. ARM-type_fold.
IPR005612. CCAAT-binding_factor.
IPR027193. Noc4.
PANTHERiPTHR12455:SF1. PTHR12455:SF1. 1 hit.
PfamiView protein in Pfam
PF03914. CBF. 1 hit.
SUPFAMiSSF48371. SSF48371. 4 hits.

Sequencei

Sequence statusi: Complete.

Q9BVI4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEREPGAAGV RRALGRRLEA VLASRSEANA VFDILAVLQS EDQEEIQEAV
60 70 80 90 100
RTCSRLFGAL LERGELFVGQ LPSEEMVMTG SQGATRKYKV WMRHRYHSCC
110 120 130 140 150
NRLGELLGHP SFQVKELALS ALLKFVQLEG AHPLEKSKWE GNYLFPRELF
160 170 180 190 200
KLVVGGLLSP EEDQSLLLSQ FREYLDYDDT RYHTMQAAVD AVARVTGQHP
210 220 230 240 250
EVPPAFWNNA FTLLSAVSLP RREPTVSSFY VKRAELWDTW KVAHLKEHRR
260 270 280 290 300
VFQAMWLSFL KHKLPLSLYK KVLLIVHDAI LPQLAQPTLM IDFLTRACDL
310 320 330 340 350
GGALSLLALN GLFILIHKHN LEYPDFYRKL YGLLDPSVFH VKYRARFFHL
360 370 380 390 400
ADLFLSSSHL PAYLVAAFAK RLARLALTAP PEALLMVLPF ICNLLRRHPA
410 420 430 440 450
CRVLVHRPHG PELDADPYDP GEEDPAQSRA LESSLWELQA LQRHYHPEVS
460 470 480 490 500
KAASVINQAL SMPEVSIAPL LELTAYEIFE RDLKKKGPEP VPLEFIPAQG
510
LLGRPGELCA QHFTLS
Length:516
Mass (Da):58,468
Last modified:June 1, 2001 - v1
Checksum:i656D835CB4207DF8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC001191 mRNA. Translation: AAH01191.1.
BC007893 mRNA. Translation: AAH07893.2.
BC071958 mRNA. Translation: AAH71958.1.
CCDSiCCDS9277.1.
RefSeqiNP_076983.1. NM_024078.2.
UniGeneiHs.558536.

Genome annotation databases

EnsembliENST00000330579; ENSP00000328854; ENSG00000184967.
GeneIDi79050.
KEGGihsa:79050.
UCSCiuc001ujz.1. human.

Similar proteinsi

Entry informationi

Entry nameiNOC4L_HUMAN
AccessioniPrimary (citable) accession number: Q9BVI4
Secondary accession number(s): Q8N2S5, Q96I14
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 16, 2005
Last sequence update: June 1, 2001
Last modified: September 27, 2017
This is version 134 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families