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Protein

Nucleolar complex protein 4 homolog

Gene

NOC4L

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  • poly(A) RNA binding Source: UniProtKB

GO - Biological processi

Complete GO annotation...

Enzyme and pathway databases

ReactomeiR-HSA-6790901. rRNA modification in the nucleus.
R-HSA-6791226. Major pathway of rRNA processing in the nucleolus.

Names & Taxonomyi

Protein namesi
Recommended name:
Nucleolar complex protein 4 homolog
Short name:
NOC4 protein homolog
Alternative name(s):
NOC4-like protein
Nucleolar complex-associated protein 4-like protein
Gene namesi
Name:NOC4L
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 12

Organism-specific databases

HGNCiHGNC:28461. NOC4L.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei297 – 31721HelicalSequence analysisAdd
BLAST
Transmembranei347 – 36721HelicalSequence analysisAdd
BLAST
Transmembranei375 – 39521HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane, Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA142671262.

Polymorphism and mutation databases

BioMutaiNOC4L.
DMDMi73621312.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 516516Nucleolar complex protein 4 homologPRO_0000173484Add
BLAST

Proteomic databases

EPDiQ9BVI4.
MaxQBiQ9BVI4.
PaxDbiQ9BVI4.
PeptideAtlasiQ9BVI4.
PRIDEiQ9BVI4.

2D gel databases

SWISS-2DPAGEQ9BVI4.

PTM databases

iPTMnetiQ9BVI4.
PhosphoSiteiQ9BVI4.
SwissPalmiQ9BVI4.

Expressioni

Gene expression databases

BgeeiENSG00000184967.
CleanExiHS_NOC4L.
ExpressionAtlasiQ9BVI4. baseline and differential.
GenevisibleiQ9BVI4. HS.

Organism-specific databases

HPAiHPA046362.
HPA053424.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
BHLHE40O145033EBI-395927,EBI-711810
DNAJA3Q96EY1-23EBI-395927,EBI-3952284
IKZF1Q134223EBI-395927,EBI-745305
KRT15P190124EBI-395927,EBI-739566
USHBP1Q8N6Y02EBI-395927,EBI-739895

Protein-protein interaction databases

BioGridi122508. 50 interactions.
DIPiDIP-32938N.
IntActiQ9BVI4. 20 interactions.
MINTiMINT-1432575.
STRINGi9606.ENSP00000328854.

Structurei

3D structure databases

ProteinModelPortaliQ9BVI4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the CBF/MAK21 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG2154. Eukaryota.
ENOG410YJPG. LUCA.
GeneTreeiENSGT00390000016776.
HOGENOMiHOG000158314.
HOVERGENiHBG060855.
InParanoidiQ9BVI4.
KOiK14771.
OMAiRRHPSCR.
OrthoDBiEOG091G07EE.
PhylomeDBiQ9BVI4.
TreeFamiTF105812.

Family and domain databases

InterProiIPR016024. ARM-type_fold.
IPR005612. CCAAT-binding_factor.
IPR027193. Noc4.
[Graphical view]
PANTHERiPTHR12455:SF0. PTHR12455:SF0. 1 hit.
PfamiPF03914. CBF. 1 hit.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 4 hits.

Sequencei

Sequence statusi: Complete.

Q9BVI4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEREPGAAGV RRALGRRLEA VLASRSEANA VFDILAVLQS EDQEEIQEAV
60 70 80 90 100
RTCSRLFGAL LERGELFVGQ LPSEEMVMTG SQGATRKYKV WMRHRYHSCC
110 120 130 140 150
NRLGELLGHP SFQVKELALS ALLKFVQLEG AHPLEKSKWE GNYLFPRELF
160 170 180 190 200
KLVVGGLLSP EEDQSLLLSQ FREYLDYDDT RYHTMQAAVD AVARVTGQHP
210 220 230 240 250
EVPPAFWNNA FTLLSAVSLP RREPTVSSFY VKRAELWDTW KVAHLKEHRR
260 270 280 290 300
VFQAMWLSFL KHKLPLSLYK KVLLIVHDAI LPQLAQPTLM IDFLTRACDL
310 320 330 340 350
GGALSLLALN GLFILIHKHN LEYPDFYRKL YGLLDPSVFH VKYRARFFHL
360 370 380 390 400
ADLFLSSSHL PAYLVAAFAK RLARLALTAP PEALLMVLPF ICNLLRRHPA
410 420 430 440 450
CRVLVHRPHG PELDADPYDP GEEDPAQSRA LESSLWELQA LQRHYHPEVS
460 470 480 490 500
KAASVINQAL SMPEVSIAPL LELTAYEIFE RDLKKKGPEP VPLEFIPAQG
510
LLGRPGELCA QHFTLS
Length:516
Mass (Da):58,468
Last modified:June 1, 2001 - v1
Checksum:i656D835CB4207DF8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC001191 mRNA. Translation: AAH01191.1.
BC007893 mRNA. Translation: AAH07893.2.
BC071958 mRNA. Translation: AAH71958.1.
CCDSiCCDS9277.1.
RefSeqiNP_076983.1. NM_024078.2.
UniGeneiHs.558536.

Genome annotation databases

EnsembliENST00000330579; ENSP00000328854; ENSG00000184967.
GeneIDi79050.
KEGGihsa:79050.
UCSCiuc001ujz.1. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC001191 mRNA. Translation: AAH01191.1.
BC007893 mRNA. Translation: AAH07893.2.
BC071958 mRNA. Translation: AAH71958.1.
CCDSiCCDS9277.1.
RefSeqiNP_076983.1. NM_024078.2.
UniGeneiHs.558536.

3D structure databases

ProteinModelPortaliQ9BVI4.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi122508. 50 interactions.
DIPiDIP-32938N.
IntActiQ9BVI4. 20 interactions.
MINTiMINT-1432575.
STRINGi9606.ENSP00000328854.

PTM databases

iPTMnetiQ9BVI4.
PhosphoSiteiQ9BVI4.
SwissPalmiQ9BVI4.

Polymorphism and mutation databases

BioMutaiNOC4L.
DMDMi73621312.

2D gel databases

SWISS-2DPAGEQ9BVI4.

Proteomic databases

EPDiQ9BVI4.
MaxQBiQ9BVI4.
PaxDbiQ9BVI4.
PeptideAtlasiQ9BVI4.
PRIDEiQ9BVI4.

Protocols and materials databases

DNASUi79050.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000330579; ENSP00000328854; ENSG00000184967.
GeneIDi79050.
KEGGihsa:79050.
UCSCiuc001ujz.1. human.

Organism-specific databases

CTDi79050.
GeneCardsiNOC4L.
HGNCiHGNC:28461. NOC4L.
HPAiHPA046362.
HPA053424.
MIMi612819. gene.
neXtProtiNX_Q9BVI4.
PharmGKBiPA142671262.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2154. Eukaryota.
ENOG410YJPG. LUCA.
GeneTreeiENSGT00390000016776.
HOGENOMiHOG000158314.
HOVERGENiHBG060855.
InParanoidiQ9BVI4.
KOiK14771.
OMAiRRHPSCR.
OrthoDBiEOG091G07EE.
PhylomeDBiQ9BVI4.
TreeFamiTF105812.

Enzyme and pathway databases

ReactomeiR-HSA-6790901. rRNA modification in the nucleus.
R-HSA-6791226. Major pathway of rRNA processing in the nucleolus.

Miscellaneous databases

ChiTaRSiNOC4L. human.
GenomeRNAii79050.
PROiQ9BVI4.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000184967.
CleanExiHS_NOC4L.
ExpressionAtlasiQ9BVI4. baseline and differential.
GenevisibleiQ9BVI4. HS.

Family and domain databases

InterProiIPR016024. ARM-type_fold.
IPR005612. CCAAT-binding_factor.
IPR027193. Noc4.
[Graphical view]
PANTHERiPTHR12455:SF0. PTHR12455:SF0. 1 hit.
PfamiPF03914. CBF. 1 hit.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 4 hits.
ProtoNetiSearch...

Entry informationi

Entry nameiNOC4L_HUMAN
AccessioniPrimary (citable) accession number: Q9BVI4
Secondary accession number(s): Q8N2S5, Q96I14
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 16, 2005
Last sequence update: June 1, 2001
Last modified: September 7, 2016
This is version 124 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.