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Protein

Phosphatidylserine synthase 2

Gene

PTDSS2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Catalyzes a base-exchange reaction in which the polar head group of phosphatidylethanolamine (PE) or phosphatidylcholine (PC) is replaced by L-serine. PTDSS2 is specific for phosphatatidylethanolamine and does not act on phosphatidylcholine.

Catalytic activityi

L-1-phosphatidylethanolamine + L-serine = L-1-phosphatidylserine + ethanolamine.

Enzyme regulationi

Inhibited in both the MAM and the ER per se by ethanolamine. Requires calcium ions.1 Publication

Kineticsi

  1. KM=120 µM for serine (in the presence of 1 mM PE)1 Publication
  1. Vmax=0.57 mmol/h/mg enzyme1 Publication

pH dependencei

Optimum pH is around 7.5.1 Publication

Pathwayi: phosphatidylserine biosynthesis

This protein is involved in the pathway phosphatidylserine biosynthesis, which is part of Phospholipid metabolism.
View all proteins of this organism that are known to be involved in the pathway phosphatidylserine biosynthesis and in Phospholipid metabolism.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Transferase

Keywords - Biological processi

Lipid biosynthesis, Lipid metabolism, Phospholipid biosynthesis, Phospholipid metabolism

Enzyme and pathway databases

BioCyciMetaCyc:HS10846-MONOMER.
ZFISH:HS10846-MONOMER.
BRENDAi2.7.8.29. 2681.
ReactomeiR-HSA-1483101. Synthesis of PS.
UniPathwayiUPA00948.

Chemistry databases

SwissLipidsiSLP:000001061.

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphatidylserine synthase 2 (EC:2.7.8.29)
Short name:
PSS-2
Short name:
PtdSer synthase 2
Alternative name(s):
Serine-exchange enzyme II
Gene namesi
Name:PTDSS2
Synonyms:PSS2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

HGNCiHGNC:15463. PTDSS2.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 62CytoplasmicSequence analysisAdd BLAST62
Transmembranei63 – 83HelicalSequence analysisAdd BLAST21
Topological domaini84 – 96LumenalSequence analysisAdd BLAST13
Transmembranei97 – 117HelicalSequence analysisAdd BLAST21
Topological domaini118 – 126CytoplasmicSequence analysis9
Transmembranei127 – 147HelicalSequence analysisAdd BLAST21
Topological domaini148 – 313LumenalSequence analysisAdd BLAST166
Transmembranei314 – 334HelicalSequence analysisAdd BLAST21
Topological domaini335CytoplasmicSequence analysis1
Transmembranei336 – 356HelicalSequence analysisAdd BLAST21
Topological domaini357 – 376LumenalSequence analysisAdd BLAST20
Transmembranei377 – 397HelicalSequence analysisAdd BLAST21
Topological domaini398 – 403CytoplasmicSequence analysis6
Transmembranei404 – 424HelicalSequence analysisAdd BLAST21
Topological domaini425 – 487LumenalSequence analysisAdd BLAST63

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000174915.
PharmGKBiPA33940.

Chemistry databases

DrugBankiDB00144. Phosphatidylserine.

Polymorphism and mutation databases

BioMutaiPTDSS2.
DMDMi49036457.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000568321 – 487Phosphatidylserine synthase 2Add BLAST487

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei16PhosphoserineCombined sources1
Modified residuei24PhosphoserineCombined sources1
Glycosylationi181N-linked (GlcNAc...)1 Publication1
Modified residuei485PhosphothreonineCombined sources1

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

EPDiQ9BVG9.
MaxQBiQ9BVG9.
PaxDbiQ9BVG9.
PeptideAtlasiQ9BVG9.
PRIDEiQ9BVG9.

PTM databases

iPTMnetiQ9BVG9.
PhosphoSitePlusiQ9BVG9.
SwissPalmiQ9BVG9.

Expressioni

Gene expression databases

BgeeiENSG00000174915.
CleanExiHS_PTDSS2.
ExpressionAtlasiQ9BVG9. baseline and differential.
GenevisibleiQ9BVG9. HS.

Organism-specific databases

HPAiHPA038928.
HPA038929.

Interactioni

Protein-protein interaction databases

BioGridi123499. 5 interactors.
IntActiQ9BVG9. 5 interactors.
STRINGi9606.ENSP00000308258.

Structurei

3D structure databases

ProteinModelPortaliQ9BVG9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG2735. Eukaryota.
ENOG410XS7H. LUCA.
GeneTreeiENSGT00530000063576.
HOGENOMiHOG000005791.
HOVERGENiHBG053766.
InParanoidiQ9BVG9.
KOiK08730.
OMAiKPHKKLG.
OrthoDBiEOG091G0CSE.
PhylomeDBiQ9BVG9.
TreeFamiTF300012.

Family and domain databases

InterProiIPR004277. PSS.
[Graphical view]
PfamiPF03034. PSS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9BVG9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRRGERRDAG GPRPESPVPA GRASLEEPPD GPSAGQATGP GEGRRSTESE
60 70 80 90 100
VYDDGTNTFF WRAHTLTVLF ILTCTLGYVT LLEETPQDTA YNTKRGIVAS
110 120 130 140 150
ILVFLCFGVT QAKDGPFSRP HPAYWRFWLC VSVVYELFLI FILFQTVQDG
160 170 180 190 200
RQFLKYVDPK LGVPLPERDY GGNCLIYDPD NETDPFHNIW DKLDGFVPAH
210 220 230 240 250
FLGWYLKTLM IRDWWMCMII SVMFEFLEYS LEHQLPNFSE CWWDHWIMDV
260 270 280 290 300
LVCNGLGIYC GMKTLEWLSL KTYKWQGLWN IPTYKGKMKR IAFQFTPYSW
310 320 330 340 350
VRFEWKPASS LRRWLAVCGI ILVFLLAELN TFYLKFVLWM PPEHYLVLLR
360 370 380 390 400
LVFFVNVGGV AMREIYDFMD DPKPHKKLGP QAWLVAAITA TELLIVVKYD
410 420 430 440 450
PHTLTLSLPF YISQCWTLGS VLALTWTVWR FFLRDITLRY KETRWQKWQN
460 470 480
KDDQGSTVGN GDQHPLGLDE DLLGPGVAEG EGAPTPN
Length:487
Mass (Da):56,253
Last modified:June 1, 2001 - v1
Checksum:iE02508F894841A4F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL834357 mRNA. Translation: CAD39022.1.
AC137894 Genomic DNA. No translation available.
AC138230 Genomic DNA. No translation available.
BC001210 mRNA. Translation: AAH01210.1.
CCDSiCCDS7696.1.
RefSeqiNP_110410.1. NM_030783.2.
UniGeneiHs.12851.
Hs.731700.

Genome annotation databases

EnsembliENST00000308020; ENSP00000308258; ENSG00000174915.
GeneIDi81490.
KEGGihsa:81490.
UCSCiuc001lpj.3. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL834357 mRNA. Translation: CAD39022.1.
AC137894 Genomic DNA. No translation available.
AC138230 Genomic DNA. No translation available.
BC001210 mRNA. Translation: AAH01210.1.
CCDSiCCDS7696.1.
RefSeqiNP_110410.1. NM_030783.2.
UniGeneiHs.12851.
Hs.731700.

3D structure databases

ProteinModelPortaliQ9BVG9.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi123499. 5 interactors.
IntActiQ9BVG9. 5 interactors.
STRINGi9606.ENSP00000308258.

Chemistry databases

DrugBankiDB00144. Phosphatidylserine.
SwissLipidsiSLP:000001061.

PTM databases

iPTMnetiQ9BVG9.
PhosphoSitePlusiQ9BVG9.
SwissPalmiQ9BVG9.

Polymorphism and mutation databases

BioMutaiPTDSS2.
DMDMi49036457.

Proteomic databases

EPDiQ9BVG9.
MaxQBiQ9BVG9.
PaxDbiQ9BVG9.
PeptideAtlasiQ9BVG9.
PRIDEiQ9BVG9.

Protocols and materials databases

DNASUi81490.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000308020; ENSP00000308258; ENSG00000174915.
GeneIDi81490.
KEGGihsa:81490.
UCSCiuc001lpj.3. human.

Organism-specific databases

CTDi81490.
GeneCardsiPTDSS2.
H-InvDBHIX0026263.
HGNCiHGNC:15463. PTDSS2.
HPAiHPA038928.
HPA038929.
MIMi612793. gene.
neXtProtiNX_Q9BVG9.
OpenTargetsiENSG00000174915.
PharmGKBiPA33940.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2735. Eukaryota.
ENOG410XS7H. LUCA.
GeneTreeiENSGT00530000063576.
HOGENOMiHOG000005791.
HOVERGENiHBG053766.
InParanoidiQ9BVG9.
KOiK08730.
OMAiKPHKKLG.
OrthoDBiEOG091G0CSE.
PhylomeDBiQ9BVG9.
TreeFamiTF300012.

Enzyme and pathway databases

UniPathwayiUPA00948.
BioCyciMetaCyc:HS10846-MONOMER.
ZFISH:HS10846-MONOMER.
BRENDAi2.7.8.29. 2681.
ReactomeiR-HSA-1483101. Synthesis of PS.

Miscellaneous databases

GenomeRNAii81490.
PROiQ9BVG9.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000174915.
CleanExiHS_PTDSS2.
ExpressionAtlasiQ9BVG9. baseline and differential.
GenevisibleiQ9BVG9. HS.

Family and domain databases

InterProiIPR004277. PSS.
[Graphical view]
PfamiPF03034. PSS. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPTSS2_HUMAN
AccessioniPrimary (citable) accession number: Q9BVG9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 21, 2004
Last sequence update: June 1, 2001
Last modified: November 30, 2016
This is version 118 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.