Q9BVG9 (PTSS2_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Phosphatidylserine synthase 2
Short name=PSS-2
Short name=PtdSer synthase 2
EC=2.7.8.-

Alternative name(s):
Serine-exchange enzyme II

Gene names

Name:	PTDSS2
Synonyms:	PSS2

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	487 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Catalyzes a base-exchange reaction in which the polar head group of phosphatidylethanolamine is replaced by L-serine.
Enzyme regulation	Inhibited by excess phosphatidylserine, but not by phosphatidylcholine or phosphatidylethanolamine By similarity.
Pathway	Phospholipid metabolism; phosphatidylserine biosynthesis.
Subcellular location	Membrane; Multi-pass membrane protein.
Sequence similarities	Belongs to the phosphatidyl serine synthase family.

Ontologies

Keywords
Biological process	Phospholipid biosynthesis
Cellular component	Membrane
Domain	Transmembrane Transmembrane helix
Molecular function	Transferase
PTM	Glycoprotein Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 487	487	Phosphatidylserine synthase 2		PRO_0000056832
Regions
	Topological domain	1 – 62	62	Cytoplasmic Potential
	Transmembrane	63 – 83	21	Helical; Potential
	Topological domain	84 – 96	13	Extracellular Potential
	Transmembrane	97 – 117	21	Helical; Potential
	Topological domain	118 – 126	9	Cytoplasmic Potential
	Transmembrane	127 – 147	21	Helical; Potential
	Topological domain	148 – 241	94	Extracellular Potential
	Transmembrane	242 – 262	21	Helical; Potential
	Topological domain	263 – 313	51	Cytoplasmic Potential
	Transmembrane	314 – 334	21	Helical; Potential
	Topological domain	335	1	Extracellular Potential
	Transmembrane	336 – 356	21	Helical; Potential
	Topological domain	357 – 376	20	Cytoplasmic Potential
	Transmembrane	377 – 397	21	Helical; Potential
	Topological domain	398 – 403	6	Extracellular Potential
	Transmembrane	404 – 424	21	Helical; Potential
	Topological domain	425 – 487	63	Cytoplasmic Potential
Amino acid modifications
	Modified residue	16	1	Phosphoserine Ref.3 Ref.4 Ref.5 Ref.6 Ref.7 Ref.9
	Modified residue	485	1	Phosphothreonine Ref.6
	Glycosylation	181	1	N-linked (GlcNAc...) Ref.8
	Glycosylation	237	1	N-linked (GlcNAc...) Potential

Sequences

	Sequence		Length	Mass (Da)
	Q9BVG9 [UniParc]. Last modified June 1, 2001. Version 1. Checksum: E02508F894841A4F	FASTA	487	56,253
	10 20 30 40 50 60 MRRGERRDAG GPRPESPVPA GRASLEEPPD GPSAGQATGP GEGRRSTESE VYDDGTNTFF 70 80 90 100 110 120 WRAHTLTVLF ILTCTLGYVT LLEETPQDTA YNTKRGIVAS ILVFLCFGVT QAKDGPFSRP 130 140 150 160 170 180 HPAYWRFWLC VSVVYELFLI FILFQTVQDG RQFLKYVDPK LGVPLPERDY GGNCLIYDPD 190 200 210 220 230 240 NETDPFHNIW DKLDGFVPAH FLGWYLKTLM IRDWWMCMII SVMFEFLEYS LEHQLPNFSE 250 260 270 280 290 300 CWWDHWIMDV LVCNGLGIYC GMKTLEWLSL KTYKWQGLWN IPTYKGKMKR IAFQFTPYSW 310 320 330 340 350 360 VRFEWKPASS LRRWLAVCGI ILVFLLAELN TFYLKFVLWM PPEHYLVLLR LVFFVNVGGV 370 380 390 400 410 420 AMREIYDFMD DPKPHKKLGP QAWLVAAITA TELLIVVKYD PHTLTLSLPF YISQCWTLGS 430 440 450 460 470 480 VLALTWTVWR FFLRDITLRY KETRWQKWQN KDDQGSTVGN GDQHPLGLDE DLLGPGVAEG EGAPTPN

References

[1]	"The full-ORF clone resource of the German cDNA consortium." Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I. BMC Genomics 8:399-399(2007) [PubMed: 17974005] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Brain.
[2]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Brain.
[3]	"Global, in vivo, and site-specific phosphorylation dynamics in signaling networks." Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M. Cell 127:635-648(2006) [PubMed: 17081983] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-16, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
[4]	"Evaluation of the low-specificity protease elastase for large-scale phosphoproteome analysis." Wang B., Malik R., Nigg E.A., Korner R. Anal. Chem. 80:9526-9533(2008) [PubMed: 19007248] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-16, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
[5]	"Phosphoproteome of resting human platelets." Zahedi R.P., Lewandrowski U., Wiesner J., Wortelkamp S., Moebius J., Schuetz C., Walter U., Gambaryan S., Sickmann A. J. Proteome Res. 7:526-534(2008) [PubMed: 18088087] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-16, MASS SPECTROMETRY. Tissue: Platelet.
[6]	"Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle." Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R., Greff Z., Keri G., Stemmann O., Mann M. Mol. Cell 31:438-448(2008) [PubMed: 18691976] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-16 AND THR-485, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
[7]	"A quantitative atlas of mitotic phosphorylation." Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P. Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed: 18669648] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-16, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
[8]	"Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry." Chen R., Jiang X., Sun D., Han G., Wang F., Ye M., Wang L., Zou H. J. Proteome Res. 8:651-661(2009) [PubMed: 19159218] [Abstract] Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-181, MASS SPECTROMETRY. Tissue: Liver.
[9]	"Large-scale proteomics analysis of the human kinome." Oppermann F.S., Gnad F., Olsen J.V., Hornberger R., Greff Z., Keri G., Mann M., Daub H. Mol. Cell. Proteomics 8:1751-1764(2009) [PubMed: 19369195] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-16, MASS SPECTROMETRY.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AL834357 mRNA. Translation: CAD39022.1. BC001210 mRNA. Translation: AAH01210.1.
IPI	IPI00006538.
RefSeq	NP_110410.1. NM_030783.1.
UniGene	Hs.12851.
3D structure databases
ProteinModelPortal	Q9BVG9.
ModBase	Search...
Protein-protein interaction databases
STRING	Q9BVG9.
PTM databases
PhosphoSite	Q9BVG9.
Polymorphism databases
DMDM	49036457.
Proteomic databases
PRIDE	Q9BVG9.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000308020; ENSP00000308258; ENSG00000174915.
GeneID	81490.
KEGG	hsa:81490.
UCSC	uc001lpj.1. human.
Organism-specific databases
CTD	81490.
GeneCards	GC11P000440.
H-InvDB	HIX0009336. HIX0026263.
HGNC	HGNC:15463. PTDSS2.
HPA	HPA038928.
MIM	612793. gene.
neXtProt	NX_Q9BVG9.
PharmGKB	PA33940.
GenAtlas	Search...
Phylogenomic databases
eggNOG	prNOG07165.
GeneTree	ENSGT00530000063576.
HOGENOM	HBG557778.
HOVERGEN	HBG053766.
InParanoid	Q9BVG9.
OMA	QTVQDGR.
OrthoDB	EOG42RD78.
PhylomeDB	Q9BVG9.
Enzyme and pathway databases
BioCyc	MetaCyc:MONOMER-14900.
Gene expression databases
ArrayExpress	Q9BVG9.
Bgee	Q9BVG9.
CleanEx	HS_PTDSS2.
Genevestigator	Q9BVG9.
GermOnline	ENSG00000174915. Homo sapiens.
Family and domain databases
InterPro	IPR004277. PSS. [Graphical view]
KO	K08730.
PANTHER	PTHR12615. PSS. 1 hit.
Pfam	PF03034. PSS. 1 hit. [Graphical view]
ProtoNet	Search...
Other
DrugBank	DB00144. Phosphatidylserine.
NextBio	71722.
SOURCE	Search...

Entry information

Entry name

PTSS2_HUMAN

Accession

Primary (citable) accession number: Q9BVG9

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 21, 2004
Last sequence update:	June 1, 2001
Last modified:	January 25, 2012
This is version 73 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.