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Q9BVG8

- KIFC3_HUMAN

UniProt

Q9BVG8 - KIFC3_HUMAN

Protein

Kinesin-like protein KIFC3

Gene

KIFC3

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 125 (01 Oct 2014)
      Sequence version 4 (16 Nov 2011)
      Previous versions | rss
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    Functioni

    Minus-end microtubule-dependent motor protein. Involved in apically targeted transport By similarity. Required for zonula adherens maintenance.By similarity1 Publication

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi528 – 5358ATP

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. microtubule motor activity Source: ProtInc

    GO - Biological processi

    1. epithelial cell-cell adhesion Source: UniProtKB
    2. Golgi organization Source: Ensembl
    3. metabolic process Source: GOC
    4. microtubule-based movement Source: InterPro
    5. visual perception Source: ProtInc
    6. zonula adherens maintenance Source: UniProtKB

    Keywords - Molecular functioni

    Motor protein

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    ReactomeiREACT_16907. Association of TriC/CCT with target proteins during biosynthesis.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Kinesin-like protein KIFC3
    Gene namesi
    Name:KIFC3
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 16

    Organism-specific databases

    HGNCiHGNC:6326. KIFC3.

    Subcellular locationi

    Cell junctionadherens junction 1 Publication. Cytoplasmcytoskeletonmicrotubule organizing centercentrosome 1 Publication. Cytoplasmic vesicle membrane By similarity; Peripheral membrane protein By similarity
    Note: Apical cell membrane. On membrane organelles immediately beneath the apical plasma membrane of renal tubular epithelial cells. Localized in the distal tubules and loops of Henle in the kidney, but not in the proximal tubules or the glomeruli, with stronger staining in the apical area of these epithelial cells By similarity. Localizes along zonula adherens only at mature cell-cell contacts.By similarity

    GO - Cellular componenti

    1. centrosome Source: UniProtKB
    2. cytoplasmic vesicle membrane Source: UniProtKB-SubCell
    3. extracellular vesicular exosome Source: UniProt
    4. Golgi apparatus Source: Ensembl
    5. kinesin complex Source: ProtInc
    6. microtubule Source: UniProtKB-KW
    7. zonula adherens Source: UniProtKB

    Keywords - Cellular componenti

    Cell junction, Cytoplasm, Cytoplasmic vesicle, Cytoskeleton, Membrane, Microtubule

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA30112.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 833833Kinesin-like protein KIFC3PRO_0000125431Add
    BLAST

    Proteomic databases

    MaxQBiQ9BVG8.
    PaxDbiQ9BVG8.
    PRIDEiQ9BVG8.

    PTM databases

    PhosphoSiteiQ9BVG8.

    Expressioni

    Gene expression databases

    ArrayExpressiQ9BVG8.
    BgeeiQ9BVG8.
    CleanExiHS_KIFC3.
    GenevestigatoriQ9BVG8.

    Organism-specific databases

    HPAiHPA021240.

    Interactioni

    Protein-protein interaction databases

    BioGridi110002. 10 interactions.
    IntActiQ9BVG8. 11 interactions.
    MINTiMINT-4989557.
    STRINGi9606.ENSP00000368976.

    Structurei

    Secondary structure

    1
    833
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Beta strandi446 – 4527
    Helixi457 – 4593
    Helixi463 – 4653
    Beta strandi469 – 4713
    Beta strandi478 – 4836
    Beta strandi486 – 4916
    Beta strandi493 – 4964
    Helixi502 – 5065
    Turni507 – 5093
    Helixi510 – 5178
    Beta strandi522 – 5298
    Helixi534 – 5385
    Beta strandi542 – 5454
    Helixi547 – 56014
    Beta strandi566 – 57813
    Beta strandi581 – 5844
    Beta strandi614 – 6163
    Helixi619 – 63214
    Helixi644 – 6463
    Beta strandi647 – 65913
    Turni660 – 6623
    Beta strandi665 – 67410
    Helixi689 – 71224
    Helixi720 – 7223
    Helixi724 – 7285
    Helixi730 – 7334
    Beta strandi738 – 7458
    Helixi749 – 7513
    Helixi752 – 76514

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    2H58X-ray1.85A443-770[»]
    ProteinModelPortaliQ9BVG8.
    SMRiQ9BVG8. Positions 445-766.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiQ9BVG8.

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini445 – 768324Kinesin motorPROSITE-ProRule annotationAdd
    BLAST

    Coiled coil

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Coiled coili102 – 362261Sequence AnalysisAdd
    BLAST
    Coiled coili395 – 43238Sequence AnalysisAdd
    BLAST

    Sequence similaritiesi

    Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.PROSITE-ProRule annotation
    Contains 1 kinesin motor domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Coiled coil

    Phylogenomic databases

    eggNOGiCOG5059.
    HOGENOMiHOG000116164.
    HOVERGENiHBG052259.
    InParanoidiQ9BVG8.
    KOiK10406.
    TreeFamiTF105238.

    Family and domain databases

    Gene3Di3.40.850.10. 1 hit.
    InterProiIPR027640. Kinesin-like_fam.
    IPR019821. Kinesin_motor_CS.
    IPR001752. Kinesin_motor_dom.
    IPR027417. P-loop_NTPase.
    [Graphical view]
    PANTHERiPTHR24115. PTHR24115. 1 hit.
    PfamiPF00225. Kinesin. 1 hit.
    [Graphical view]
    PRINTSiPR00380. KINESINHEAVY.
    SMARTiSM00129. KISc. 1 hit.
    [Graphical view]
    SUPFAMiSSF52540. SSF52540. 1 hit.
    PROSITEiPS00411. KINESIN_MOTOR_1. 1 hit.
    PS50067. KINESIN_MOTOR_2. 1 hit.
    [Graphical view]

    Sequences (4)i

    Sequence statusi: Complete.

    This entry describes 4 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q9BVG8-3) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MVPSRRTWNL GATPSLRGLW RVGRAPEPEP GMARPAPAPA SPAARPFPHT    50
    GPGRLRTGRG KDTPVCGDED SSARSAARPA LAQCRALSVD WAGPGSPHGL 100
    YLTLQVEHLK EKLISQAQEV SRLRSELGGT DLEKHRDLLM VENERLRQEM 150
    RRCEAELQEL RTKPAGPCPG CEHSQESAQL RDKLSQLQLE MAESKGMLSE 200
    LNLEVQQKTD RLAEVELRLK DCLAEKAQEE ERLSRRLRDS HETIASLRAQ 250
    SPPVKYVIKT VEVESSKTKQ ALSESQARNQ HLQEQVAMQR QVLKEMEQQL 300
    QSSHQLTARL RAQIAMYESE LERAHGQMLE EMQSLEEDKN RAIEEAFARA 350
    QVEMKAVHEN LAGVRTNLLT LQPALRTLTN DYNGLKRQVR GFPLLLQEAL 400
    RSVKAEIGQA IEEVNSNNQE LLRKYRRELQ LRKKCHNELV RLKGNIRVIA 450
    RVRPVTKEDG EGPEATNAVT FDADDDSIIH LLHKGKPVSF ELDKVFSPQA 500
    SQQDVFQEVQ ALVTSCIDGF NVCIFAYGQT GAGKTYTMEG TAENPGINQR 550
    ALQLLFSEVQ EKASDWEYTI TVSAAEIYNE VLRDLLGKEP QEKLEIRLCP 600
    DGSGQLYVPG LTEFQVQSVD DINKVFEFGH TNRTTEFTNL NEHSSRSHAL 650
    LIVTVRGVDC STGLRTTGKL NLVDLAGSER VGKSGAEGSR LREAQHINKS 700
    LSALGDVIAA LRSRQGHVPF RNSKLTYLLQ DSLSGDSKTL MVVQVSPVEK 750
    NTSETLYSLK FAERVRSVEL GPGLRRAELG SWSSQEHLEW EPACQTPQPS 800
    ARAHSAPSSG TSSRPGSIRR KLQPSGKSRP LPV 833

    Note: No experimental confirmation available.

    Length:833
    Mass (Da):92,775
    Last modified:November 16, 2011 - v4
    Checksum:i50983587270BDC2F
    GO
    Isoform 2 (identifier: Q9BVG8-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         826-833: GKSRPLPV → A

    Show »
    Length:826
    Mass (Da):92,011
    Checksum:iFA9B17728E570AE8
    GO
    Isoform 3 (identifier: Q9BVG8-4) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         626-637: FEFGHTNRTTEF → WRREPLTTATLL
         638-833: Missing.

    Note: No experimental confirmation available. May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.

    Show »
    Length:637
    Mass (Da):71,607
    Checksum:i367120F4FC3C3B78
    GO
    Isoform 4 (identifier: Q9BVG8-5) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-139: Missing.
         826-833: GKSRPLPV → A

    Note: No experimental confirmation available.

    Show »
    Length:687
    Mass (Da):77,089
    Checksum:iEA21C203FC8B29A8
    GO

    Sequence cautioni

    The sequence AAH34234.1 differs from that shown. Reason: Intron retention.
    The sequence AAH41132.1 differs from that shown. Reason: Intron retention.
    The sequence AAH47051.1 differs from that shown. Reason: Intron retention.
    The sequence BAD92527.1 differs from that shown. Reason: Erroneous initiation.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti150 – 1501M → L in AAC24153. (PubMed:9782090)Curated
    Sequence conflicti185 – 1851S → P in AAH34234. (PubMed:15489334)Curated
    Sequence conflicti281 – 2811H → S in AAH08014. (PubMed:15489334)Curated
    Sequence conflicti736 – 7361D → G in AAH34234. (PubMed:15489334)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti391 – 3911G → V.1 Publication
    Corresponds to variant rs17854089 [ dbSNP | Ensembl ].
    VAR_028114

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 139139Missing in isoform 4. 1 PublicationVSP_043724Add
    BLAST
    Alternative sequencei626 – 63712FEFGH…RTTEF → WRREPLTTATLL in isoform 3. 1 PublicationVSP_022361Add
    BLAST
    Alternative sequencei638 – 833196Missing in isoform 3. 1 PublicationVSP_022362Add
    BLAST
    Alternative sequencei826 – 8338GKSRPLPV → A in isoform 2 and isoform 4. 4 PublicationsVSP_021018

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK291737 mRNA. Translation: BAF84426.1.
    AB209290 mRNA. Translation: BAD92527.1. Different initiation.
    AC092118 Genomic DNA. No translation available.
    CH471092 Genomic DNA. Translation: EAW82955.1.
    BC001211 mRNA. Translation: AAH01211.2.
    BC008014 mRNA. Translation: AAH08014.1.
    BC034234 mRNA. Translation: AAH34234.1. Different initiation.
    BC041132 mRNA. Translation: AAH41132.1. Different initiation.
    BC047051 mRNA. Translation: AAH47051.1. Sequence problems.
    AF004426 mRNA. Translation: AAC24153.1.
    CCDSiCCDS10789.2. [Q9BVG8-3]
    CCDS45493.1. [Q9BVG8-2]
    CCDS45494.1. [Q9BVG8-5]
    RefSeqiNP_001123571.1. NM_001130099.1. [Q9BVG8-5]
    NP_001123572.1. NM_001130100.1. [Q9BVG8-2]
    NP_005541.3. NM_005550.3. [Q9BVG8-3]
    UniGeneiHs.23131.

    Genome annotation databases

    EnsembliENST00000379655; ENSP00000368976; ENSG00000140859. [Q9BVG8-3]
    ENST00000421376; ENSP00000396399; ENSG00000140859. [Q9BVG8-5]
    ENST00000445690; ENSP00000401696; ENSG00000140859. [Q9BVG8-2]
    ENST00000465878; ENSP00000454659; ENSG00000140859. [Q9BVG8-5]
    ENST00000562903; ENSP00000456239; ENSG00000140859. [Q9BVG8-5]
    ENST00000564136; ENSP00000458009; ENSG00000140859.
    GeneIDi3801.
    KEGGihsa:3801.
    UCSCiuc002emm.3. human. [Q9BVG8-5]
    uc002emp.3. human. [Q9BVG8-3]
    uc002emq.3. human. [Q9BVG8-2]

    Polymorphism databases

    DMDMi357529584.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK291737 mRNA. Translation: BAF84426.1 .
    AB209290 mRNA. Translation: BAD92527.1 . Different initiation.
    AC092118 Genomic DNA. No translation available.
    CH471092 Genomic DNA. Translation: EAW82955.1 .
    BC001211 mRNA. Translation: AAH01211.2 .
    BC008014 mRNA. Translation: AAH08014.1 .
    BC034234 mRNA. Translation: AAH34234.1 . Different initiation.
    BC041132 mRNA. Translation: AAH41132.1 . Different initiation.
    BC047051 mRNA. Translation: AAH47051.1 . Sequence problems.
    AF004426 mRNA. Translation: AAC24153.1 .
    CCDSi CCDS10789.2. [Q9BVG8-3 ]
    CCDS45493.1. [Q9BVG8-2 ]
    CCDS45494.1. [Q9BVG8-5 ]
    RefSeqi NP_001123571.1. NM_001130099.1. [Q9BVG8-5 ]
    NP_001123572.1. NM_001130100.1. [Q9BVG8-2 ]
    NP_005541.3. NM_005550.3. [Q9BVG8-3 ]
    UniGenei Hs.23131.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    2H58 X-ray 1.85 A 443-770 [» ]
    ProteinModelPortali Q9BVG8.
    SMRi Q9BVG8. Positions 445-766.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 110002. 10 interactions.
    IntActi Q9BVG8. 11 interactions.
    MINTi MINT-4989557.
    STRINGi 9606.ENSP00000368976.

    Chemistry

    ChEMBLi CHEMBL1075119.

    PTM databases

    PhosphoSitei Q9BVG8.

    Polymorphism databases

    DMDMi 357529584.

    Proteomic databases

    MaxQBi Q9BVG8.
    PaxDbi Q9BVG8.
    PRIDEi Q9BVG8.

    Protocols and materials databases

    DNASUi 3801.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000379655 ; ENSP00000368976 ; ENSG00000140859 . [Q9BVG8-3 ]
    ENST00000421376 ; ENSP00000396399 ; ENSG00000140859 . [Q9BVG8-5 ]
    ENST00000445690 ; ENSP00000401696 ; ENSG00000140859 . [Q9BVG8-2 ]
    ENST00000465878 ; ENSP00000454659 ; ENSG00000140859 . [Q9BVG8-5 ]
    ENST00000562903 ; ENSP00000456239 ; ENSG00000140859 . [Q9BVG8-5 ]
    ENST00000564136 ; ENSP00000458009 ; ENSG00000140859 .
    GeneIDi 3801.
    KEGGi hsa:3801.
    UCSCi uc002emm.3. human. [Q9BVG8-5 ]
    uc002emp.3. human. [Q9BVG8-3 ]
    uc002emq.3. human. [Q9BVG8-2 ]

    Organism-specific databases

    CTDi 3801.
    GeneCardsi GC16M057792.
    HGNCi HGNC:6326. KIFC3.
    HPAi HPA021240.
    MIMi 604535. gene.
    neXtProti NX_Q9BVG8.
    PharmGKBi PA30112.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG5059.
    HOGENOMi HOG000116164.
    HOVERGENi HBG052259.
    InParanoidi Q9BVG8.
    KOi K10406.
    TreeFami TF105238.

    Enzyme and pathway databases

    Reactomei REACT_16907. Association of TriC/CCT with target proteins during biosynthesis.

    Miscellaneous databases

    ChiTaRSi KIFC3. human.
    EvolutionaryTracei Q9BVG8.
    GeneWikii KIFC3.
    GenomeRNAii 3801.
    NextBioi 14931.
    PROi Q9BVG8.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q9BVG8.
    Bgeei Q9BVG8.
    CleanExi HS_KIFC3.
    Genevestigatori Q9BVG8.

    Family and domain databases

    Gene3Di 3.40.850.10. 1 hit.
    InterProi IPR027640. Kinesin-like_fam.
    IPR019821. Kinesin_motor_CS.
    IPR001752. Kinesin_motor_dom.
    IPR027417. P-loop_NTPase.
    [Graphical view ]
    PANTHERi PTHR24115. PTHR24115. 1 hit.
    Pfami PF00225. Kinesin. 1 hit.
    [Graphical view ]
    PRINTSi PR00380. KINESINHEAVY.
    SMARTi SM00129. KISc. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52540. SSF52540. 1 hit.
    PROSITEi PS00411. KINESIN_MOTOR_1. 1 hit.
    PS50067. KINESIN_MOTOR_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 4).
      Tissue: Placenta.
    2. Totoki Y., Toyoda A., Takeda T., Sakaki Y., Tanaka A., Yokoyama S., Ohara O., Nagase T., Kikuno R.F.
      Submitted (MAR-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
      Tissue: Brain.
    3. "The sequence and analysis of duplication-rich human chromosome 16."
      Martin J., Han C., Gordon L.A., Terry A., Prabhakar S., She X., Xie G., Hellsten U., Chan Y.M., Altherr M., Couronne O., Aerts A., Bajorek E., Black S., Blumer H., Branscomb E., Brown N.C., Bruno W.J.
      , Buckingham J.M., Callen D.F., Campbell C.S., Campbell M.L., Campbell E.W., Caoile C., Challacombe J.F., Chasteen L.A., Chertkov O., Chi H.C., Christensen M., Clark L.M., Cohn J.D., Denys M., Detter J.C., Dickson M., Dimitrijevic-Bussod M., Escobar J., Fawcett J.J., Flowers D., Fotopulos D., Glavina T., Gomez M., Gonzales E., Goodstein D., Goodwin L.A., Grady D.L., Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Hildebrand C.E., Huang W., Israni S., Jett J., Jewett P.B., Kadner K., Kimball H., Kobayashi A., Krawczyk M.-C., Leyba T., Longmire J.L., Lopez F., Lou Y., Lowry S., Ludeman T., Manohar C.F., Mark G.A., McMurray K.L., Meincke L.J., Morgan J., Moyzis R.K., Mundt M.O., Munk A.C., Nandkeshwar R.D., Pitluck S., Pollard M., Predki P., Parson-Quintana B., Ramirez L., Rash S., Retterer J., Ricke D.O., Robinson D.L., Rodriguez A., Salamov A., Saunders E.H., Scott D., Shough T., Stallings R.L., Stalvey M., Sutherland R.D., Tapia R., Tesmer J.G., Thayer N., Thompson L.S., Tice H., Torney D.C., Tran-Gyamfi M., Tsai M., Ulanovsky L.E., Ustaszewska A., Vo N., White P.S., Williams A.L., Wills P.L., Wu J.-R., Wu K., Yang J., DeJong P., Bruce D., Doggett N.A., Deaven L., Schmutz J., Grimwood J., Richardson P., Rokhsar D.S., Eichler E.E., Gilna P., Lucas S.M., Myers R.M., Rubin E.M., Pennacchio L.A.
      Nature 432:988-994(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 105-833 (ISOFORM 2), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 106-833 (ISOFORM 3), VARIANT VAL-391.
      Tissue: Brain, Muscle and Testis.
    6. "Cloning of a novel C-terminal kinesin (KIFC3) that maps to human chromosome 16q13-q21 and thus is a candidate gene for Bardet-Biedl syndrome."
      Hoang E.H., Whitehead J.L., Dose A.C., Burnside B.
      Genomics 52:219-222(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 86-833 (ISOFORM 2).
      Tissue: Retina.
    7. "Anchorage of microtubule minus ends to adherens junctions regulates epithelial cell-cell contacts."
      Meng W., Mushika Y., Ichii T., Takeichi M.
      Cell 135:948-959(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, SUBCELLULAR LOCATION.
    8. "Crystal structure of the KIFC3 motor domain in complex with ADP."
      Structural genomics consortium (SGC)
      Submitted (JUN-2006) to the PDB data bank
      Cited for: X-RAY CRYSTALLOGRAPHY (1.85 ANGSTROMS) OF 443-770 IN COMPLEX WITH ADP.

    Entry informationi

    Entry nameiKIFC3_HUMAN
    AccessioniPrimary (citable) accession number: Q9BVG8
    Secondary accession number(s): A8K6S2
    , O75299, Q49A29, Q49AQ0, Q59G19, Q8IUT3, Q96HW6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: August 15, 2003
    Last sequence update: November 16, 2011
    Last modified: October 1, 2014
    This is version 125 of the entry and version 4 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. Human chromosome 16
      Human chromosome 16: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    6. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3