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Protein

Kinesin-like protein KIFC3

Gene

KIFC3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Minus-end microtubule-dependent motor protein. Involved in apically targeted transport (By similarity). Required for zonula adherens maintenance.By similarity1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi528 – 535ATP8

GO - Molecular functioni

GO - Biological processi

  • epithelial cell-cell adhesion Source: UniProtKB
  • Golgi organization Source: Ensembl
  • microtubule-based movement Source: GO_Central
  • visual perception Source: ProtInc
  • zonula adherens maintenance Source: UniProtKB

Keywordsi

Molecular functionMotor protein
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-HSA-390471. Association of TriC/CCT with target proteins during biosynthesis.

Names & Taxonomyi

Protein namesi
Recommended name:
Kinesin-like protein KIFC3
Gene namesi
Name:KIFC3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 16

Organism-specific databases

HGNCiHGNC:6326. KIFC3.

Subcellular locationi

GO - Cellular componenti

  • centrosome Source: UniProtKB
  • cytoplasmic vesicle membrane Source: UniProtKB-SubCell
  • extracellular exosome Source: UniProtKB
  • Golgi apparatus Source: Ensembl
  • kinesin complex Source: GO_Central
  • microtubule Source: UniProtKB-KW
  • zonula adherens Source: UniProtKB

Keywords - Cellular componenti

Cell junction, Cytoplasm, Cytoplasmic vesicle, Cytoskeleton, Membrane, Microtubule

Pathology & Biotechi

Organism-specific databases

DisGeNETi3801.
OpenTargetsiENSG00000140859.
PharmGKBiPA30112.

Chemistry databases

ChEMBLiCHEMBL1075119.

Polymorphism and mutation databases

BioMutaiKIFC3.
DMDMi357529584.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001254311 – 833Kinesin-like protein KIFC3Add BLAST833

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei813PhosphoserineCombined sources1
Modified residuei817PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ9BVG8.
PeptideAtlasiQ9BVG8.
PRIDEiQ9BVG8.

PTM databases

iPTMnetiQ9BVG8.
PhosphoSitePlusiQ9BVG8.

Expressioni

Gene expression databases

BgeeiENSG00000140859.
CleanExiHS_KIFC3.
ExpressionAtlasiQ9BVG8. baseline and differential.
GenevisibleiQ9BVG8. HS.

Organism-specific databases

HPAiHPA021240.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
ABI2Q9NYB93EBI-2125614,EBI-743598
AESQ081173EBI-2125614,EBI-717810
ATF2P153363EBI-2125614,EBI-1170906
BCL6P411823EBI-2125614,EBI-765407
C1orf109Q9NX044EBI-2125614,EBI-8643161
CARD9Q9H257-24EBI-14069005,EBI-11530605
CBX8Q9HC523EBI-2125614,EBI-712912
CCDC102BQ68D863EBI-2125614,EBI-10171570
CCDC136Q96JN2-23EBI-2125614,EBI-10171416
CCDC146Q8IYE04EBI-14069005,EBI-10749669
CCDC28AQ7Z6N93EBI-2125614,EBI-10258115
CCDC28AQ8IWP93EBI-2125614,EBI-355471
CCHCR1Q8TD31-34EBI-14069005,EBI-10175300
CDK18Q070023EBI-2125614,EBI-746238
CDR2Q018503EBI-2125614,EBI-1181367
CEP170P1Q96L144EBI-2125614,EBI-743488
CEP55Q53EZ43EBI-2125614,EBI-747776
CEP57L1Q8IYX8-23EBI-2125614,EBI-10181988
CLIP4Q8N3C73EBI-2125614,EBI-5655540
CREB5Q02930-33EBI-2125614,EBI-10192698
CYTH4Q8WWE83EBI-2125614,EBI-10277443
DCTN2Q135614EBI-14069005,EBI-715074
DCXO436023EBI-2125614,EBI-8646694
DEUP1Q05D603EBI-2125614,EBI-748597
DTNBP1Q96EV83EBI-2125614,EBI-465804
ESRRGP625083EBI-2125614,EBI-2834260
EXOC5O004716EBI-14069005,EBI-949824
FAM124AQ86V423EBI-2125614,EBI-744506
FAM208BQ5VWN64EBI-14069005,EBI-745958
FANCLQ9NW383EBI-2125614,EBI-2339898
FCHSD2O948683EBI-2125614,EBI-1215612
FLJ13057Q53SE73EBI-2125614,EBI-10172181
GOLGA2Q083793EBI-2125614,EBI-618309
GORASP2Q9H8Y83EBI-2125614,EBI-739467
HAUS1Q96CS23EBI-2125614,EBI-2514791
HSBP1O755065EBI-2125614,EBI-748664
ICA1LQ8NDH63EBI-2125614,EBI-10269733
IQUBQ8NA544EBI-14069005,EBI-10220600
ITGB3BPQ133523EBI-2125614,EBI-712105
ITGB3BPQ13352-53EBI-2125614,EBI-10175826
KANK2Q63ZY34EBI-14069005,EBI-2556193
KANSL1Q7Z3B33EBI-2125614,EBI-740244
KRT15P190123EBI-2125614,EBI-739566
KRT19P087273EBI-2125614,EBI-742756
KRT31Q153233EBI-2125614,EBI-948001
KRT40Q6A1623EBI-2125614,EBI-10171697
KRT5P136473EBI-2125614,EBI-702187
KRT6AP025385EBI-2125614,EBI-702198
KRT6BP042593EBI-2125614,EBI-740907
KRT6CP486683EBI-2125614,EBI-2564105
LENG1Q96BZ83EBI-2125614,EBI-726510
LIN37Q96GY33EBI-2125614,EBI-748884
LNX1Q8TBB14EBI-14069005,EBI-739832
LZTS2Q9BRK43EBI-2125614,EBI-741037
MCM7P339933EBI-2125614,EBI-355924
MED4Q9NPJ64EBI-14069005,EBI-394607
MFAP1P550813EBI-2125614,EBI-1048159
MID2Q9UJV3-24EBI-14069005,EBI-10172526
MOSP005403EBI-2125614,EBI-1757866
NDC80O147774EBI-14069005,EBI-715849
NDEL1Q9GZM83EBI-2125614,EBI-928842
NECAB2Q7Z6G3-23EBI-2125614,EBI-10172876
NEFLI6L9F63EBI-2125614,EBI-10178578
NUP62P371983EBI-2125614,EBI-347978
PHC2Q8IXK03EBI-2125614,EBI-713786
PPP1R13BQ96KQ44EBI-14069005,EBI-1105153
PRKAA2P546464EBI-2125614,EBI-1383852
PSMB1P206183EBI-2125614,EBI-372273
RAD51DO757713EBI-2125614,EBI-1055693
RSPH14Q9UHP63EBI-2125614,EBI-748350
SCELO951713EBI-2125614,EBI-7543896
SIAH1Q8IUQ43EBI-2125614,EBI-747107
SMARCE1Q969G34EBI-2125614,EBI-455078
SOX5P357113EBI-2125614,EBI-3505701
SPERTQ8NA615EBI-2125614,EBI-741724
SPERTQ8NA61-24EBI-14069005,EBI-11524851
SYCE1Q8N0S23EBI-2125614,EBI-6872807
TCEANCQ8N8B73EBI-2125614,EBI-954696
TNIP1Q150253EBI-2125614,EBI-357849
TPM3Q5VU623EBI-2125614,EBI-10184033
TRAF2Q129333EBI-2125614,EBI-355744
TRIM23P364063EBI-2125614,EBI-740098
TRIM27P143733EBI-2125614,EBI-719493
TRIM41Q8WV443EBI-2125614,EBI-725997
TRIM54Q9BYV23EBI-2125614,EBI-2130429
TSG101Q998163EBI-2125614,EBI-346882
TSGA10IPQ3SY004EBI-14069005,EBI-10241197
TSR2Q969E83EBI-2125614,EBI-746981
USP2O756043EBI-2125614,EBI-743272
ZBTB16Q055164EBI-14069005,EBI-711925
ZBTB8AQ96BR93EBI-2125614,EBI-742740
ZGPATQ8N5A54EBI-2125614,EBI-3439227
ZGPATQ8N5A5-23EBI-2125614,EBI-10183064
ZNF180Q9UJW83EBI-2125614,EBI-10322527
ZNF20P170243EBI-2125614,EBI-717634
ZNF572Q7Z3I76EBI-2125614,EBI-10172590
ZNF655Q8N7203EBI-2125614,EBI-625509

GO - Molecular functioni

Protein-protein interaction databases

BioGridi110002. 122 interactors.
DIPiDIP-52406N.
IntActiQ9BVG8. 218 interactors.
MINTiMINT-4989557.
STRINGi9606.ENSP00000368976.

Structurei

Secondary structure

1833
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi446 – 452Combined sources7
Helixi457 – 459Combined sources3
Helixi463 – 465Combined sources3
Beta strandi469 – 471Combined sources3
Beta strandi478 – 483Combined sources6
Beta strandi486 – 491Combined sources6
Beta strandi493 – 496Combined sources4
Helixi502 – 506Combined sources5
Turni507 – 509Combined sources3
Helixi510 – 517Combined sources8
Beta strandi522 – 529Combined sources8
Helixi534 – 538Combined sources5
Beta strandi542 – 545Combined sources4
Helixi547 – 560Combined sources14
Beta strandi566 – 578Combined sources13
Beta strandi581 – 584Combined sources4
Beta strandi614 – 616Combined sources3
Helixi619 – 632Combined sources14
Helixi644 – 646Combined sources3
Beta strandi647 – 659Combined sources13
Turni660 – 662Combined sources3
Beta strandi665 – 674Combined sources10
Helixi689 – 712Combined sources24
Helixi720 – 722Combined sources3
Helixi724 – 728Combined sources5
Helixi730 – 733Combined sources4
Beta strandi738 – 745Combined sources8
Helixi749 – 751Combined sources3
Helixi752 – 765Combined sources14

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2H58X-ray1.85A443-770[»]
ProteinModelPortaliQ9BVG8.
SMRiQ9BVG8.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9BVG8.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini445 – 768Kinesin motorPROSITE-ProRule annotationAdd BLAST324

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili102 – 362Sequence analysisAdd BLAST261
Coiled coili395 – 432Sequence analysisAdd BLAST38

Sequence similaritiesi

Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG0239. Eukaryota.
COG5059. LUCA.
GeneTreeiENSGT00550000074610.
HOGENOMiHOG000116164.
HOVERGENiHBG052259.
InParanoidiQ9BVG8.
KOiK10406.
OMAiIKYVIKT.
OrthoDBiEOG091G01HX.
TreeFamiTF105238.

Family and domain databases

Gene3Di3.40.850.10. 1 hit.
InterProiView protein in InterPro
IPR027325. KIFC3.
IPR019821. Kinesin_motor_CS.
IPR001752. Kinesin_motor_dom.
IPR027417. P-loop_NTPase.
PANTHERiPTHR24115:SF655. PTHR24115:SF655. 1 hit.
PfamiView protein in Pfam
PF00225. Kinesin. 1 hit.
PRINTSiPR00380. KINESINHEAVY.
SMARTiView protein in SMART
SM00129. KISc. 1 hit.
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiView protein in PROSITE
PS00411. KINESIN_MOTOR_1. 1 hit.
PS50067. KINESIN_MOTOR_2. 1 hit.

Sequences (5)i

Sequence statusi: Complete.

This entry describes 5 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9BVG8-3) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MVPSRRTWNL GATPSLRGLW RVGRAPEPEP GMARPAPAPA SPAARPFPHT
60 70 80 90 100
GPGRLRTGRG KDTPVCGDED SSARSAARPA LAQCRALSVD WAGPGSPHGL
110 120 130 140 150
YLTLQVEHLK EKLISQAQEV SRLRSELGGT DLEKHRDLLM VENERLRQEM
160 170 180 190 200
RRCEAELQEL RTKPAGPCPG CEHSQESAQL RDKLSQLQLE MAESKGMLSE
210 220 230 240 250
LNLEVQQKTD RLAEVELRLK DCLAEKAQEE ERLSRRLRDS HETIASLRAQ
260 270 280 290 300
SPPVKYVIKT VEVESSKTKQ ALSESQARNQ HLQEQVAMQR QVLKEMEQQL
310 320 330 340 350
QSSHQLTARL RAQIAMYESE LERAHGQMLE EMQSLEEDKN RAIEEAFARA
360 370 380 390 400
QVEMKAVHEN LAGVRTNLLT LQPALRTLTN DYNGLKRQVR GFPLLLQEAL
410 420 430 440 450
RSVKAEIGQA IEEVNSNNQE LLRKYRRELQ LRKKCHNELV RLKGNIRVIA
460 470 480 490 500
RVRPVTKEDG EGPEATNAVT FDADDDSIIH LLHKGKPVSF ELDKVFSPQA
510 520 530 540 550
SQQDVFQEVQ ALVTSCIDGF NVCIFAYGQT GAGKTYTMEG TAENPGINQR
560 570 580 590 600
ALQLLFSEVQ EKASDWEYTI TVSAAEIYNE VLRDLLGKEP QEKLEIRLCP
610 620 630 640 650
DGSGQLYVPG LTEFQVQSVD DINKVFEFGH TNRTTEFTNL NEHSSRSHAL
660 670 680 690 700
LIVTVRGVDC STGLRTTGKL NLVDLAGSER VGKSGAEGSR LREAQHINKS
710 720 730 740 750
LSALGDVIAA LRSRQGHVPF RNSKLTYLLQ DSLSGDSKTL MVVQVSPVEK
760 770 780 790 800
NTSETLYSLK FAERVRSVEL GPGLRRAELG SWSSQEHLEW EPACQTPQPS
810 820 830
ARAHSAPSSG TSSRPGSIRR KLQPSGKSRP LPV
Note: No experimental confirmation available.
Length:833
Mass (Da):92,775
Last modified:November 16, 2011 - v4
Checksum:i50983587270BDC2F
GO
Isoform 2 (identifier: Q9BVG8-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     826-833: GKSRPLPV → A

Show »
Length:826
Mass (Da):92,011
Checksum:iFA9B17728E570AE8
GO
Isoform 3 (identifier: Q9BVG8-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     626-637: FEFGHTNRTTEF → WRREPLTTATLL
     638-833: Missing.

Note: No experimental confirmation available. May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.
Show »
Length:637
Mass (Da):71,607
Checksum:i367120F4FC3C3B78
GO
Isoform 4 (identifier: Q9BVG8-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-139: Missing.
     826-833: GKSRPLPV → A

Note: No experimental confirmation available.
Show »
Length:687
Mass (Da):77,089
Checksum:iEA21C203FC8B29A8
GO
Isoform 5 (identifier: Q9BVG8-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MCASACKDTAAWCPEEAAEPQAM
     826-833: GKSRPLPV → A

Note: No experimental confirmation available.
Show »
Length:848
Mass (Da):94,276
Checksum:i23229203DAE90BDF
GO

Sequence cautioni

The sequence AAH34234 differs from that shown. Intron retention.Curated
The sequence AAH41132 differs from that shown. Intron retention.Curated
The sequence AAH47051 differs from that shown. Intron retention.Curated
The sequence BAD92527 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti150M → L in AAC24153 (PubMed:9782090).Curated1
Sequence conflicti185S → P in AAH34234 (PubMed:15489334).Curated1
Sequence conflicti281H → S in AAH08014 (PubMed:15489334).Curated1
Sequence conflicti736D → G in AAH34234 (PubMed:15489334).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_028114391G → V1 PublicationCorresponds to variant dbSNP:rs17854089Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0437241 – 139Missing in isoform 4. 1 PublicationAdd BLAST139
Alternative sequenceiVSP_0572241M → MCASACKDTAAWCPEEAAEP QAM in isoform 5. 1 Publication1
Alternative sequenceiVSP_022361626 – 637FEFGH…RTTEF → WRREPLTTATLL in isoform 3. 1 PublicationAdd BLAST12
Alternative sequenceiVSP_022362638 – 833Missing in isoform 3. 1 PublicationAdd BLAST196
Alternative sequenceiVSP_021018826 – 833GKSRPLPV → A in isoform 2, isoform 4 and isoform 5. 4 Publications8

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK291737 mRNA. Translation: BAF84426.1.
AK296995 mRNA. Translation: BAH12470.1.
AB209290 mRNA. Translation: BAD92527.1. Different initiation.
AC010543 Genomic DNA. No translation available.
AC092118 Genomic DNA. No translation available.
FO082293 Genomic DNA. No translation available.
CH471092 Genomic DNA. Translation: EAW82955.1.
BC001211 mRNA. Translation: AAH01211.2.
BC008014 mRNA. Translation: AAH08014.1.
BC034234 mRNA. Translation: AAH34234.1. Different initiation.
BC041132 mRNA. Translation: AAH41132.1. Different initiation.
BC047051 mRNA. Translation: AAH47051.1. Sequence problems.
AF004426 mRNA. Translation: AAC24153.1.
CCDSiCCDS10789.2. [Q9BVG8-3]
CCDS45493.1. [Q9BVG8-2]
CCDS45494.1. [Q9BVG8-5]
CCDS81989.1. [Q9BVG8-6]
RefSeqiNP_001123571.1. NM_001130099.1. [Q9BVG8-5]
NP_001123572.1. NM_001130100.1. [Q9BVG8-2]
NP_001305639.1. NM_001318710.1. [Q9BVG8-6]
NP_001305640.1. NM_001318711.1.
NP_001305641.1. NM_001318712.1.
NP_001305642.1. NM_001318713.1.
NP_001305643.1. NM_001318714.1. [Q9BVG8-5]
NP_001305644.1. NM_001318715.1. [Q9BVG8-5]
NP_005541.3. NM_005550.3. [Q9BVG8-3]
UniGeneiHs.23131.

Genome annotation databases

EnsembliENST00000379655; ENSP00000368976; ENSG00000140859. [Q9BVG8-3]
ENST00000421376; ENSP00000396399; ENSG00000140859. [Q9BVG8-5]
ENST00000445690; ENSP00000401696; ENSG00000140859. [Q9BVG8-2]
ENST00000465878; ENSP00000454659; ENSG00000140859. [Q9BVG8-5]
ENST00000541240; ENSP00000442008; ENSG00000140859. [Q9BVG8-6]
ENST00000562903; ENSP00000456239; ENSG00000140859. [Q9BVG8-5]
GeneIDi3801.
KEGGihsa:3801.
UCSCiuc002emm.4. human. [Q9BVG8-3]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiKIFC3_HUMAN
AccessioniPrimary (citable) accession number: Q9BVG8
Secondary accession number(s): A8K6S2
, B7Z484, O75299, Q49A29, Q49AQ0, Q59G19, Q8IUT3, Q96HW6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 15, 2003
Last sequence update: November 16, 2011
Last modified: August 30, 2017
This is version 153 of the entry and version 4 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families