Q9BVG8 (KIFC3_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Kinesin-like protein KIFC3

Gene names

Name:

KIFC3

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	833 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Minus-end microtubule-dependent motor protein. Involved in apically targeted transport By similarity. Required for zonula adherens maintenance. Ref.7
Subcellular location	Cell junction › adherens junction. Cytoplasm › cytoskeleton › centrosome. Cytoplasmic vesicle membrane; Peripheral membrane protein By similarity. Note: Apical cell membrane. On membrane organelles immediately beneath the apical plasma membrane of renal tubular epithelial cells. Localized in the distal tubules and loops of Henle in the kidney, but not in the proximal tubules or the glomeruli, with stronger staining in the apical area of these epithelial cells By similarity. Localizes along zonula adherens only at mature cell-cell contacts. Ref.7
Sequence similarities	Belongs to the kinesin-like protein family. Contains 1 kinesin-motor domain.
Sequence caution	The sequence AAH34234.1 differs from that shown. Reason: Intron retention. The sequence AAH41132.1 differs from that shown. Reason: Intron retention. The sequence AAH47051.1 differs from that shown. Reason: Intron retention. The sequence BAD92527.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
Cellular component	Cell junction Cytoplasm Cytoplasmic vesicle Cytoskeleton Membrane Microtubule
Coding sequence diversity	Alternative splicing Polymorphism
Domain	Coiled coil
Ligand	ATP-binding Nucleotide-binding
Molecular function	Motor protein
Technical term	3D-structure Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	Golgi organization Inferred from electronic annotation. Source: Compara epithelial cell-cell adhesion Inferred from mutant phenotype Ref.7. Source: UniProtKB microtubule-based movement Inferred from electronic annotation. Source: InterPro visual perception Traceable author statement Ref.6. Source: ProtInc zonula adherens maintenance Inferred from mutant phenotype Ref.7. Source: UniProtKB
Cellular_component	Golgi apparatus Inferred from electronic annotation. Source: Compara centrosome Inferred from direct assay Ref.7. Source: UniProtKB cytoplasmic vesicle membrane Inferred from electronic annotation. Source: UniProtKB-SubCell kinesin complex Traceable author statement Ref.6. Source: ProtInc microtubule Inferred from electronic annotation. Source: UniProtKB-KW zonula adherens Inferred from direct assay Ref.7. Source: UniProtKB
Molecular_function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW microtubule motor activity Traceable author statement Ref.6. Source: ProtInc minus-end-directed microtubule motor activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Alternative products

This entry describes 4 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q9BVG8-3)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Note: No experimental confirmation available.

Isoform 2 (identifier: Q9BVG8-2)

The sequence of this isoform differs from the canonical sequence as follows:
     826-833: GKSRPLPV → A

Isoform 3 (identifier: Q9BVG8-4)

The sequence of this isoform differs from the canonical sequence as follows:
     626-637: FEFGHTNRTTEF → WRREPLTTATLL
     638-833: Missing.

Note: No experimental confirmation available. May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.

Isoform 4 (identifier: Q9BVG8-5)

The sequence of this isoform differs from the canonical sequence as follows:
     1-139: Missing.
     826-833: GKSRPLPV → A

Note: No experimental confirmation available.

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 833

833

Kinesin-like protein KIFC3

PRO_0000125431

Regions

Domain

442 – 699

258

Kinesin-motor

Nucleotide binding

528 – 535

8

ATP

Coiled coil

102 – 362

261

Potential

Coiled coil

395 – 432

38

Potential

Natural variations

Alternative sequence

1 – 139

139

Missing in isoform 4.

VSP_043724

Alternative sequence

626 – 637

12

FEFGH…RTTEF → WRREPLTTATLL in isoform 3.

VSP_022361

Alternative sequence

638 – 833

196

Missing in isoform 3.

VSP_022362

Alternative sequence

826 – 833

8

GKSRPLPV → A in isoform 2 and isoform 4.

VSP_021018

Natural variant

391

1

G → V. Ref.5
Corresponds to variant rs17854089 [ dbSNP | Ensembl ].

VAR_028114

Experimental info

Sequence conflict

150

1

M → L in AAC24153. Ref.6

Sequence conflict

185

1

S → P in AAH34234. Ref.5

Sequence conflict

281

1

H → S in AAH08014. Ref.5

Sequence conflict

736

1

D → G in AAH34234. Ref.5

Secondary structure

1

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833

Helix Strand Turn

Details...

Beta strand

446 – 452

7

Helix

457 – 459

3

Helix

463 – 465

3

Beta strand

469 – 471

3

Beta strand

478 – 483

6

Beta strand

486 – 491

6

Beta strand

493 – 496

4

Helix

502 – 506

5

Turn

507 – 509

3

Helix

510 – 517

8

Beta strand

522 – 529

8

Helix

534 – 538

5

Beta strand

542 – 545

4

Helix

547 – 560

14

Beta strand

566 – 578

13

Beta strand

581 – 584

4

Beta strand

614 – 616

3

Helix

619 – 632

14

Helix

644 – 646

3

Beta strand

647 – 659

13

Turn

660 – 662

3

Beta strand

665 – 674

10

Helix

689 – 712

24

Helix

720 – 722

3

Helix

724 – 728

5

Helix

730 – 733

4

Beta strand

738 – 745

8

Helix

749 – 751

3

Helix

752 – 765

14

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified November 16, 2011. Version 4. Checksum: 50983587270BDC2F	FASTA	833	92,775
	10 20 30 40 50 60 MVPSRRTWNL GATPSLRGLW RVGRAPEPEP GMARPAPAPA SPAARPFPHT GPGRLRTGRG 70 80 90 100 110 120 KDTPVCGDED SSARSAARPA LAQCRALSVD WAGPGSPHGL YLTLQVEHLK EKLISQAQEV 130 140 150 160 170 180 SRLRSELGGT DLEKHRDLLM VENERLRQEM RRCEAELQEL RTKPAGPCPG CEHSQESAQL 190 200 210 220 230 240 RDKLSQLQLE MAESKGMLSE LNLEVQQKTD RLAEVELRLK DCLAEKAQEE ERLSRRLRDS 250 260 270 280 290 300 HETIASLRAQ SPPVKYVIKT VEVESSKTKQ ALSESQARNQ HLQEQVAMQR QVLKEMEQQL 310 320 330 340 350 360 QSSHQLTARL RAQIAMYESE LERAHGQMLE EMQSLEEDKN RAIEEAFARA QVEMKAVHEN 370 380 390 400 410 420 LAGVRTNLLT LQPALRTLTN DYNGLKRQVR GFPLLLQEAL RSVKAEIGQA IEEVNSNNQE 430 440 450 460 470 480 LLRKYRRELQ LRKKCHNELV RLKGNIRVIA RVRPVTKEDG EGPEATNAVT FDADDDSIIH 490 500 510 520 530 540 LLHKGKPVSF ELDKVFSPQA SQQDVFQEVQ ALVTSCIDGF NVCIFAYGQT GAGKTYTMEG 550 560 570 580 590 600 TAENPGINQR ALQLLFSEVQ EKASDWEYTI TVSAAEIYNE VLRDLLGKEP QEKLEIRLCP 610 620 630 640 650 660 DGSGQLYVPG LTEFQVQSVD DINKVFEFGH TNRTTEFTNL NEHSSRSHAL LIVTVRGVDC 670 680 690 700 710 720 STGLRTTGKL NLVDLAGSER VGKSGAEGSR LREAQHINKS LSALGDVIAA LRSRQGHVPF 730 740 750 760 770 780 RNSKLTYLLQ DSLSGDSKTL MVVQVSPVEK NTSETLYSLK FAERVRSVEL GPGLRRAELG 790 800 810 820 830 SWSSQEHLEW EPACQTPQPS ARAHSAPSSG TSSRPGSIRR KLQPSGKSRP LPV
	Isoform 2 [UniParc]. Checksum: FA9B17728E570AE8	FASTA	826	92,011
	10 20 30 40 50 60 MVPSRRTWNL GATPSLRGLW RVGRAPEPEP GMARPAPAPA SPAARPFPHT GPGRLRTGRG 70 80 90 100 110 120 KDTPVCGDED SSARSAARPA LAQCRALSVD WAGPGSPHGL YLTLQVEHLK EKLISQAQEV 130 140 150 160 170 180 SRLRSELGGT DLEKHRDLLM VENERLRQEM RRCEAELQEL RTKPAGPCPG CEHSQESAQL 190 200 210 220 230 240 RDKLSQLQLE MAESKGMLSE LNLEVQQKTD RLAEVELRLK DCLAEKAQEE ERLSRRLRDS 250 260 270 280 290 300 HETIASLRAQ SPPVKYVIKT VEVESSKTKQ ALSESQARNQ HLQEQVAMQR QVLKEMEQQL 310 320 330 340 350 360 QSSHQLTARL RAQIAMYESE LERAHGQMLE EMQSLEEDKN RAIEEAFARA QVEMKAVHEN 370 380 390 400 410 420 LAGVRTNLLT LQPALRTLTN DYNGLKRQVR GFPLLLQEAL RSVKAEIGQA IEEVNSNNQE 430 440 450 460 470 480 LLRKYRRELQ LRKKCHNELV RLKGNIRVIA RVRPVTKEDG EGPEATNAVT FDADDDSIIH 490 500 510 520 530 540 LLHKGKPVSF ELDKVFSPQA SQQDVFQEVQ ALVTSCIDGF NVCIFAYGQT GAGKTYTMEG 550 560 570 580 590 600 TAENPGINQR ALQLLFSEVQ EKASDWEYTI TVSAAEIYNE VLRDLLGKEP QEKLEIRLCP 610 620 630 640 650 660 DGSGQLYVPG LTEFQVQSVD DINKVFEFGH TNRTTEFTNL NEHSSRSHAL LIVTVRGVDC 670 680 690 700 710 720 STGLRTTGKL NLVDLAGSER VGKSGAEGSR LREAQHINKS LSALGDVIAA LRSRQGHVPF 730 740 750 760 770 780 RNSKLTYLLQ DSLSGDSKTL MVVQVSPVEK NTSETLYSLK FAERVRSVEL GPGLRRAELG 790 800 810 820 SWSSQEHLEW EPACQTPQPS ARAHSAPSSG TSSRPGSIRR KLQPSA
	Isoform 3 [UniParc]. Checksum: 367120F4FC3C3B78	FASTA	637	71,607
	10 20 30 40 50 60 MVPSRRTWNL GATPSLRGLW RVGRAPEPEP GMARPAPAPA SPAARPFPHT GPGRLRTGRG 70 80 90 100 110 120 KDTPVCGDED SSARSAARPA LAQCRALSVD WAGPGSPHGL YLTLQVEHLK EKLISQAQEV 130 140 150 160 170 180 SRLRSELGGT DLEKHRDLLM VENERLRQEM RRCEAELQEL RTKPAGPCPG CEHSQESAQL 190 200 210 220 230 240 RDKLSQLQLE MAESKGMLSE LNLEVQQKTD RLAEVELRLK DCLAEKAQEE ERLSRRLRDS 250 260 270 280 290 300 HETIASLRAQ SPPVKYVIKT VEVESSKTKQ ALSESQARNQ HLQEQVAMQR QVLKEMEQQL 310 320 330 340 350 360 QSSHQLTARL RAQIAMYESE LERAHGQMLE EMQSLEEDKN RAIEEAFARA QVEMKAVHEN 370 380 390 400 410 420 LAGVRTNLLT LQPALRTLTN DYNGLKRQVR GFPLLLQEAL RSVKAEIGQA IEEVNSNNQE 430 440 450 460 470 480 LLRKYRRELQ LRKKCHNELV RLKGNIRVIA RVRPVTKEDG EGPEATNAVT FDADDDSIIH 490 500 510 520 530 540 LLHKGKPVSF ELDKVFSPQA SQQDVFQEVQ ALVTSCIDGF NVCIFAYGQT GAGKTYTMEG 550 560 570 580 590 600 TAENPGINQR ALQLLFSEVQ EKASDWEYTI TVSAAEIYNE VLRDLLGKEP QEKLEIRLCP 610 620 630 DGSGQLYVPG LTEFQVQSVD DINKVWRREP LTTATLL
	Isoform 4 [UniParc]. Checksum: EA21C203FC8B29A8	FASTA	687	77,089
	10 20 30 40 50 60 MVENERLRQE MRRCEAELQE LRTKPAGPCP GCEHSQESAQ LRDKLSQLQL EMAESKGMLS 70 80 90 100 110 120 ELNLEVQQKT DRLAEVELRL KDCLAEKAQE EERLSRRLRD SHETIASLRA QSPPVKYVIK 130 140 150 160 170 180 TVEVESSKTK QALSESQARN QHLQEQVAMQ RQVLKEMEQQ LQSSHQLTAR LRAQIAMYES 190 200 210 220 230 240 ELERAHGQML EEMQSLEEDK NRAIEEAFAR AQVEMKAVHE NLAGVRTNLL TLQPALRTLT 250 260 270 280 290 300 NDYNGLKRQV RGFPLLLQEA LRSVKAEIGQ AIEEVNSNNQ ELLRKYRREL QLRKKCHNEL 310 320 330 340 350 360 VRLKGNIRVI ARVRPVTKED GEGPEATNAV TFDADDDSII HLLHKGKPVS FELDKVFSPQ 370 380 390 400 410 420 ASQQDVFQEV QALVTSCIDG FNVCIFAYGQ TGAGKTYTME GTAENPGINQ RALQLLFSEV 430 440 450 460 470 480 QEKASDWEYT ITVSAAEIYN EVLRDLLGKE PQEKLEIRLC PDGSGQLYVP GLTEFQVQSV 490 500 510 520 530 540 DDINKVFEFG HTNRTTEFTN LNEHSSRSHA LLIVTVRGVD CSTGLRTTGK LNLVDLAGSE 550 560 570 580 590 600 RVGKSGAEGS RLREAQHINK SLSALGDVIA ALRSRQGHVP FRNSKLTYLL QDSLSGDSKT 610 620 630 640 650 660 LMVVQVSPVE KNTSETLYSL KFAERVRSVE LGPGLRRAEL GSWSSQEHLE WEPACQTPQP 670 680 SARAHSAPSS GTSSRPGSIR RKLQPSA

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 4). Tissue: Placenta.
[2]	Totoki Y., Toyoda A., Takeda T., Sakaki Y., Tanaka A., Yokoyama S., Ohara O., Nagase T., Kikuno R.F. Submitted (MAR-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2). Tissue: Brain.
[3]	"The sequence and analysis of duplication-rich human chromosome 16." Martin J., Han C., Gordon L.A., Terry A., Prabhakar S., She X., Xie G., Hellsten U., Chan Y.M., Altherr M., Couronne O., Aerts A., Bajorek E., Black S., Blumer H., Branscomb E., Brown N.C., Bruno W.J. , Buckingham J.M., Callen D.F., Campbell C.S., Campbell M.L., Campbell E.W., Caoile C., Challacombe J.F., Chasteen L.A., Chertkov O., Chi H.C., Christensen M., Clark L.M., Cohn J.D., Denys M., Detter J.C., Dickson M., Dimitrijevic-Bussod M., Escobar J., Fawcett J.J., Flowers D., Fotopulos D., Glavina T., Gomez M., Gonzales E., Goodstein D., Goodwin L.A., Grady D.L., Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Hildebrand C.E., Huang W., Israni S., Jett J., Jewett P.B., Kadner K., Kimball H., Kobayashi A., Krawczyk M.-C., Leyba T., Longmire J.L., Lopez F., Lou Y., Lowry S., Ludeman T., Manohar C.F., Mark G.A., McMurray K.L., Meincke L.J., Morgan J., Moyzis R.K., Mundt M.O., Munk A.C., Nandkeshwar R.D., Pitluck S., Pollard M., Predki P., Parson-Quintana B., Ramirez L., Rash S., Retterer J., Ricke D.O., Robinson D.L., Rodriguez A., Salamov A., Saunders E.H., Scott D., Shough T., Stallings R.L., Stalvey M., Sutherland R.D., Tapia R., Tesmer J.G., Thayer N., Thompson L.S., Tice H., Torney D.C., Tran-Gyamfi M., Tsai M., Ulanovsky L.E., Ustaszewska A., Vo N., White P.S., Williams A.L., Wills P.L., Wu J.-R., Wu K., Yang J., DeJong P., Bruce D., Doggett N.A., Deaven L., Schmutz J., Grimwood J., Richardson P., Rokhsar D.S., Eichler E.E., Gilna P., Lucas S.M., Myers R.M., Rubin E.M., Pennacchio L.A. Nature 432:988-994(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]	Mural R.J., Istrail S., Sutton G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 105-833 (ISOFORM 2), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 106-833 (ISOFORM 3), VARIANT VAL-391. Tissue: Brain, Muscle and Testis.
[6]	"Cloning of a novel C-terminal kinesin (KIFC3) that maps to human chromosome 16q13-q21 and thus is a candidate gene for Bardet-Biedl syndrome." Hoang E.H., Whitehead J.L., Dose A.C., Burnside B. Genomics 52:219-222(1998) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 86-833 (ISOFORM 2). Tissue: Retina.
[7]	"Anchorage of microtubule minus ends to adherens junctions regulates epithelial cell-cell contacts." Meng W., Mushika Y., Ichii T., Takeichi M. Cell 135:948-959(2008) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION, SUBCELLULAR LOCATION.
[8]	"Crystal structure of the KIFC3 motor domain in complex with ADP." Structural genomics consortium (SGC) Submitted (JUN-2006) to the PDB data bank Cited for: X-RAY CRYSTALLOGRAPHY (1.85 ANGSTROMS) OF 443-770 IN COMPLEX WITH ADP.
+	Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

AK291737 mRNA. Translation: BAF84426.1.
AB209290 mRNA. Translation: BAD92527.1. Different initiation.
AC092118 Genomic DNA. No translation available.
CH471092 Genomic DNA. Translation: EAW82955.1.
BC001211 mRNA. Translation: AAH01211.2.
BC008014 mRNA. Translation: AAH08014.1.
BC034234 mRNA. Translation: AAH34234.1. Different initiation.
BC041132 mRNA. Translation: AAH41132.1. Different initiation.
BC047051 mRNA. Translation: AAH47051.1. Sequence problems.
AF004426 mRNA. Translation: AAC24153.1.

IPI

IPI00151119.
IPI00867631.
IPI00909341.
IPI01015611.

RefSeq

NP_001123571.1. NM_001130099.1.
NP_001123572.1. NM_001130100.1.
NP_005541.3. NM_005550.3.

UniGene

Hs.23131.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
2H58	X-ray	1.85	A	443-770	[»]

ProteinModelPortal

Q9BVG8.

SMR

Q9BVG8. Positions 445-766.

ModBase

Search...

Protein-protein interaction databases

IntAct

Q9BVG8. 8 interactions.

STRING

9606.ENSP00000368976.

PTM databases

PhosphoSite

Q9BVG8.

Polymorphism databases

DMDM

124056471.

Proteomic databases

PaxDb

Q9BVG8.

PRIDE

Q9BVG8.

Protocols and materials databases

DNASU

3801.

StructuralBiologyKnowledgebase

Search...

Genome annotation databases

Ensembl

ENST00000379655; ENSP00000368976; ENSG00000140859.
ENST00000421376; ENSP00000396399; ENSG00000140859.
ENST00000445690; ENSP00000401696; ENSG00000140859.
ENST00000465878; ENSP00000454659; ENSG00000140859.
ENST00000562903; ENSP00000456239; ENSG00000140859.
ENST00000564136; ENSP00000458009; ENSG00000140859.
ENST00000593285; ENSP00000469595; ENSG00000269180.
ENST00000594074; ENSP00000472587; ENSG00000269180.
ENST00000597902; ENSP00000469179; ENSG00000269180.
ENST00000599270; ENSP00000470797; ENSG00000269180.
ENST00000600009; ENSP00000472239; ENSG00000269180.
ENST00000601710; ENSP00000469004; ENSG00000269180.

GeneID

3801.

KEGG

hsa:3801.

UCSC

uc002emm.3. human.
uc002emp.3. human.

Organism-specific databases

CTD

3801.

GeneCards

GC16M057792.

HGNC

HGNC:6326. KIFC3.

HPA

HPA021240.

MIM

604535. gene.

neXtProt

NX_Q9BVG8.

PharmGKB

PA30112.

GenAtlas

Search...

Phylogenomic databases

eggNOG

COG5059.

HOGENOM

HOG000116164.

HOVERGEN

HBG052259.

InParanoid

Q9BVG8.

KO

K10406.

OrthoDB

EOG4HHP28.

Enzyme and pathway databases

Reactome

REACT_17015. Metabolism of proteins.

Gene expression databases

ArrayExpress

Q9BVG8.

Bgee

Q9BVG8.

CleanEx

HS_KIFC3.

Genevestigator

Q9BVG8.

GermOnline

ENSG00000140859. Homo sapiens.

Family and domain databases

Gene3D

3.40.850.10. 1 hit.

InterPro

IPR027325. KIFC3.
IPR019821. Kinesin_motor_CS.
IPR001752. Kinesin_motor_dom.
[Graphical view]

PANTHER

PTHR24115:SF173. PTHR24115:SF173. 1 hit.

Pfam

PF00225. Kinesin. 1 hit.
[Graphical view]

PRINTS

PR00380. KINESINHEAVY.

SMART

SM00129. KISc. 1 hit.
[Graphical view]

PROSITE

PS00411. KINESIN_MOTOR_DOMAIN1. 1 hit.
PS50067. KINESIN_MOTOR_DOMAIN2. 1 hit.
[Graphical view]

ProtoNet

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Other

ChEMBL

CHEMBL1075119.

ChiTaRS

KIFC3. human.

EvolutionaryTrace

Q9BVG8.

GenomeRNAi

3801.

NextBio

14931.

SOURCE

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Entry information

Entry name

KIFC3_HUMAN

Accession

Primary (citable) accession number: Q9BVG8
Secondary accession number(s): A8K6S2 , O75299, Q49A29, Q49AQ0, Q59G19, Q8IUT3, Q96HW6

Entry history

Integrated into UniProtKB/Swiss-Prot:	August 15, 2003
Last sequence update:	November 16, 2011
Last modified:	May 1, 2013
This is version 110 of the entry and version 4 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.