Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

Q9BVG8 (KIFC3_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 120. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (6) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Kinesin-like protein KIFC3
Gene names
Name:KIFC3
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length833 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Minus-end microtubule-dependent motor protein. Involved in apically targeted transport By similarity. Required for zonula adherens maintenance. Ref.7

Subcellular location

Cell junctionadherens junction. Cytoplasmcytoskeletonmicrotubule organizing centercentrosome. Cytoplasmic vesicle membrane; Peripheral membrane protein By similarity. Note: Apical cell membrane. On membrane organelles immediately beneath the apical plasma membrane of renal tubular epithelial cells. Localized in the distal tubules and loops of Henle in the kidney, but not in the proximal tubules or the glomeruli, with stronger staining in the apical area of these epithelial cells By similarity. Localizes along zonula adherens only at mature cell-cell contacts. Ref.7

Sequence similarities

Belongs to the kinesin-like protein family.

Contains 1 kinesin-motor domain.

Sequence caution

The sequence AAH34234.1 differs from that shown. Reason: Intron retention.

The sequence AAH41132.1 differs from that shown. Reason: Intron retention.

The sequence AAH47051.1 differs from that shown. Reason: Intron retention.

The sequence BAD92527.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
   Cellular componentCell junction
Cytoplasm
Cytoplasmic vesicle
Cytoskeleton
Membrane
Microtubule
   Coding sequence diversityAlternative splicing
Polymorphism
   DomainCoiled coil
   LigandATP-binding
Nucleotide-binding
   Molecular functionMotor protein
   Technical term3D-structure
Complete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processGolgi organization

Inferred from electronic annotation. Source: Ensembl

epithelial cell-cell adhesion

Inferred from mutant phenotype Ref.7. Source: UniProtKB

metabolic process

Traceable author statement Ref.6. Source: GOC

microtubule-based movement

Inferred from electronic annotation. Source: InterPro

visual perception

Traceable author statement Ref.6. Source: ProtInc

zonula adherens maintenance

Inferred from mutant phenotype Ref.7. Source: UniProtKB

   Cellular_componentGolgi apparatus

Inferred from electronic annotation. Source: Ensembl

centrosome

Inferred from direct assay Ref.7. Source: UniProtKB

cytoplasmic vesicle membrane

Inferred from electronic annotation. Source: UniProtKB-SubCell

extracellular vesicular exosome

Inferred from direct assay PubMed 19056867. Source: UniProt

kinesin complex

Traceable author statement Ref.6. Source: ProtInc

microtubule

Inferred from electronic annotation. Source: UniProtKB-KW

zonula adherens

Inferred from direct assay Ref.7. Source: UniProtKB

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-KW

microtubule motor activity

Traceable author statement Ref.6. Source: ProtInc

Complete GO annotation...

Alternative products

This entry describes 4 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q9BVG8-3)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Note: No experimental confirmation available.
Isoform 2 (identifier: Q9BVG8-2)

The sequence of this isoform differs from the canonical sequence as follows:
     826-833: GKSRPLPV → A
Isoform 3 (identifier: Q9BVG8-4)

The sequence of this isoform differs from the canonical sequence as follows:
     626-637: FEFGHTNRTTEF → WRREPLTTATLL
     638-833: Missing.
Note: No experimental confirmation available. May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.
Isoform 4 (identifier: Q9BVG8-5)

The sequence of this isoform differs from the canonical sequence as follows:
     1-139: Missing.
     826-833: GKSRPLPV → A
Note: No experimental confirmation available.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 833833Kinesin-like protein KIFC3
PRO_0000125431

Regions

Domain442 – 699258Kinesin-motor
Nucleotide binding528 – 5358ATP
Coiled coil102 – 362261 Potential
Coiled coil395 – 43238 Potential

Natural variations

Alternative sequence1 – 139139Missing in isoform 4.
VSP_043724
Alternative sequence626 – 63712FEFGH…RTTEF → WRREPLTTATLL in isoform 3.
VSP_022361
Alternative sequence638 – 833196Missing in isoform 3.
VSP_022362
Alternative sequence826 – 8338GKSRPLPV → A in isoform 2 and isoform 4.
VSP_021018
Natural variant3911G → V. Ref.5
Corresponds to variant rs17854089 [ dbSNP | Ensembl ].
VAR_028114

Experimental info

Sequence conflict1501M → L in AAC24153. Ref.6
Sequence conflict1851S → P in AAH34234. Ref.5
Sequence conflict2811H → S in AAH08014. Ref.5
Sequence conflict7361D → G in AAH34234. Ref.5

Secondary structure

...................................................... 833
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified November 16, 2011. Version 4.
Checksum: 50983587270BDC2F

FASTA83392,775
        10         20         30         40         50         60 
MVPSRRTWNL GATPSLRGLW RVGRAPEPEP GMARPAPAPA SPAARPFPHT GPGRLRTGRG 

        70         80         90        100        110        120 
KDTPVCGDED SSARSAARPA LAQCRALSVD WAGPGSPHGL YLTLQVEHLK EKLISQAQEV 

       130        140        150        160        170        180 
SRLRSELGGT DLEKHRDLLM VENERLRQEM RRCEAELQEL RTKPAGPCPG CEHSQESAQL 

       190        200        210        220        230        240 
RDKLSQLQLE MAESKGMLSE LNLEVQQKTD RLAEVELRLK DCLAEKAQEE ERLSRRLRDS 

       250        260        270        280        290        300 
HETIASLRAQ SPPVKYVIKT VEVESSKTKQ ALSESQARNQ HLQEQVAMQR QVLKEMEQQL 

       310        320        330        340        350        360 
QSSHQLTARL RAQIAMYESE LERAHGQMLE EMQSLEEDKN RAIEEAFARA QVEMKAVHEN 

       370        380        390        400        410        420 
LAGVRTNLLT LQPALRTLTN DYNGLKRQVR GFPLLLQEAL RSVKAEIGQA IEEVNSNNQE 

       430        440        450        460        470        480 
LLRKYRRELQ LRKKCHNELV RLKGNIRVIA RVRPVTKEDG EGPEATNAVT FDADDDSIIH 

       490        500        510        520        530        540 
LLHKGKPVSF ELDKVFSPQA SQQDVFQEVQ ALVTSCIDGF NVCIFAYGQT GAGKTYTMEG 

       550        560        570        580        590        600 
TAENPGINQR ALQLLFSEVQ EKASDWEYTI TVSAAEIYNE VLRDLLGKEP QEKLEIRLCP 

       610        620        630        640        650        660 
DGSGQLYVPG LTEFQVQSVD DINKVFEFGH TNRTTEFTNL NEHSSRSHAL LIVTVRGVDC 

       670        680        690        700        710        720 
STGLRTTGKL NLVDLAGSER VGKSGAEGSR LREAQHINKS LSALGDVIAA LRSRQGHVPF 

       730        740        750        760        770        780 
RNSKLTYLLQ DSLSGDSKTL MVVQVSPVEK NTSETLYSLK FAERVRSVEL GPGLRRAELG 

       790        800        810        820        830 
SWSSQEHLEW EPACQTPQPS ARAHSAPSSG TSSRPGSIRR KLQPSGKSRP LPV 

« Hide

Isoform 2 [UniParc].

Checksum: FA9B17728E570AE8
Show »

FASTA82692,011
Isoform 3 [UniParc].

Checksum: 367120F4FC3C3B78
Show »

FASTA63771,607
Isoform 4 [UniParc].

Checksum: EA21C203FC8B29A8
Show »

FASTA68777,089

References

« Hide 'large scale' references
[1]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 4).
Tissue: Placenta.
[2]Totoki Y., Toyoda A., Takeda T., Sakaki Y., Tanaka A., Yokoyama S., Ohara O., Nagase T., Kikuno R.F.
Submitted (MAR-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
Tissue: Brain.
[3]"The sequence and analysis of duplication-rich human chromosome 16."
Martin J., Han C., Gordon L.A., Terry A., Prabhakar S., She X., Xie G., Hellsten U., Chan Y.M., Altherr M., Couronne O., Aerts A., Bajorek E., Black S., Blumer H., Branscomb E., Brown N.C., Bruno W.J. expand/collapse author list , Buckingham J.M., Callen D.F., Campbell C.S., Campbell M.L., Campbell E.W., Caoile C., Challacombe J.F., Chasteen L.A., Chertkov O., Chi H.C., Christensen M., Clark L.M., Cohn J.D., Denys M., Detter J.C., Dickson M., Dimitrijevic-Bussod M., Escobar J., Fawcett J.J., Flowers D., Fotopulos D., Glavina T., Gomez M., Gonzales E., Goodstein D., Goodwin L.A., Grady D.L., Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Hildebrand C.E., Huang W., Israni S., Jett J., Jewett P.B., Kadner K., Kimball H., Kobayashi A., Krawczyk M.-C., Leyba T., Longmire J.L., Lopez F., Lou Y., Lowry S., Ludeman T., Manohar C.F., Mark G.A., McMurray K.L., Meincke L.J., Morgan J., Moyzis R.K., Mundt M.O., Munk A.C., Nandkeshwar R.D., Pitluck S., Pollard M., Predki P., Parson-Quintana B., Ramirez L., Rash S., Retterer J., Ricke D.O., Robinson D.L., Rodriguez A., Salamov A., Saunders E.H., Scott D., Shough T., Stallings R.L., Stalvey M., Sutherland R.D., Tapia R., Tesmer J.G., Thayer N., Thompson L.S., Tice H., Torney D.C., Tran-Gyamfi M., Tsai M., Ulanovsky L.E., Ustaszewska A., Vo N., White P.S., Williams A.L., Wills P.L., Wu J.-R., Wu K., Yang J., DeJong P., Bruce D., Doggett N.A., Deaven L., Schmutz J., Grimwood J., Richardson P., Rokhsar D.S., Eichler E.E., Gilna P., Lucas S.M., Myers R.M., Rubin E.M., Pennacchio L.A.
Nature 432:988-994(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]Mural R.J., Istrail S., Sutton G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 105-833 (ISOFORM 2), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 106-833 (ISOFORM 3), VARIANT VAL-391.
Tissue: Brain, Muscle and Testis.
[6]"Cloning of a novel C-terminal kinesin (KIFC3) that maps to human chromosome 16q13-q21 and thus is a candidate gene for Bardet-Biedl syndrome."
Hoang E.H., Whitehead J.L., Dose A.C., Burnside B.
Genomics 52:219-222(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 86-833 (ISOFORM 2).
Tissue: Retina.
[7]"Anchorage of microtubule minus ends to adherens junctions regulates epithelial cell-cell contacts."
Meng W., Mushika Y., Ichii T., Takeichi M.
Cell 135:948-959(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION, SUBCELLULAR LOCATION.
[8]"Crystal structure of the KIFC3 motor domain in complex with ADP."
Structural genomics consortium (SGC)
Submitted (JUN-2006) to the PDB data bank
Cited for: X-RAY CRYSTALLOGRAPHY (1.85 ANGSTROMS) OF 443-770 IN COMPLEX WITH ADP.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AK291737 mRNA. Translation: BAF84426.1.
AB209290 mRNA. Translation: BAD92527.1. Different initiation.
AC092118 Genomic DNA. No translation available.
CH471092 Genomic DNA. Translation: EAW82955.1.
BC001211 mRNA. Translation: AAH01211.2.
BC008014 mRNA. Translation: AAH08014.1.
BC034234 mRNA. Translation: AAH34234.1. Different initiation.
BC041132 mRNA. Translation: AAH41132.1. Different initiation.
BC047051 mRNA. Translation: AAH47051.1. Sequence problems.
AF004426 mRNA. Translation: AAC24153.1.
RefSeqNP_001123571.1. NM_001130099.1.
NP_001123572.1. NM_001130100.1.
NP_005541.3. NM_005550.3.
UniGeneHs.23131.

3D structure databases

PDBe
RCSB PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
2H58X-ray1.85A443-770[»]
ProteinModelPortalQ9BVG8.
SMRQ9BVG8. Positions 360-391, 445-766.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid110002. 10 interactions.
IntActQ9BVG8. 11 interactions.
MINTMINT-4989557.
STRING9606.ENSP00000368976.

Chemistry

ChEMBLCHEMBL1075119.

PTM databases

PhosphoSiteQ9BVG8.

Polymorphism databases

DMDM357529584.

Proteomic databases

PaxDbQ9BVG8.
PRIDEQ9BVG8.

Protocols and materials databases

DNASU3801.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000379655; ENSP00000368976; ENSG00000140859. [Q9BVG8-3]
ENST00000421376; ENSP00000396399; ENSG00000140859. [Q9BVG8-5]
ENST00000445690; ENSP00000401696; ENSG00000140859. [Q9BVG8-2]
ENST00000465878; ENSP00000454659; ENSG00000140859. [Q9BVG8-5]
ENST00000562903; ENSP00000456239; ENSG00000140859. [Q9BVG8-5]
ENST00000564136; ENSP00000458009; ENSG00000140859.
ENST00000593285; ENSP00000469595; ENSG00000269180. [Q9BVG8-3]
ENST00000594074; ENSP00000472587; ENSG00000269180.
ENST00000597902; ENSP00000469179; ENSG00000269180. [Q9BVG8-5]
ENST00000599270; ENSP00000470797; ENSG00000269180. [Q9BVG8-2]
ENST00000600009; ENSP00000472239; ENSG00000269180. [Q9BVG8-5]
ENST00000601710; ENSP00000469004; ENSG00000269180. [Q9BVG8-5]
GeneID3801.
KEGGhsa:3801.
UCSCuc002emm.3. human. [Q9BVG8-5]
uc002emp.3. human. [Q9BVG8-3]
uc002emq.3. human. [Q9BVG8-2]

Organism-specific databases

CTD3801.
GeneCardsGC16M057792.
HGNCHGNC:6326. KIFC3.
HPAHPA021240.
MIM604535. gene.
neXtProtNX_Q9BVG8.
PharmGKBPA30112.
GenAtlasSearch...

Phylogenomic databases

eggNOGCOG5059.
HOGENOMHOG000116164.
HOVERGENHBG052259.
InParanoidQ9BVG8.
KOK10406.
TreeFamTF105238.

Enzyme and pathway databases

ReactomeREACT_17015. Metabolism of proteins.

Gene expression databases

ArrayExpressQ9BVG8.
BgeeQ9BVG8.
CleanExHS_KIFC3.
GenevestigatorQ9BVG8.

Family and domain databases

Gene3D3.40.850.10. 1 hit.
InterProIPR027640. Kinesin-like_fam.
IPR019821. Kinesin_motor_CS.
IPR001752. Kinesin_motor_dom.
IPR027417. P-loop_NTPase.
[Graphical view]
PANTHERPTHR24115. PTHR24115. 1 hit.
PfamPF00225. Kinesin. 1 hit.
[Graphical view]
PRINTSPR00380. KINESINHEAVY.
SMARTSM00129. KISc. 1 hit.
[Graphical view]
SUPFAMSSF52540. SSF52540. 1 hit.
PROSITEPS00411. KINESIN_MOTOR_DOMAIN1. 1 hit.
PS50067. KINESIN_MOTOR_DOMAIN2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSKIFC3. human.
EvolutionaryTraceQ9BVG8.
GeneWikiKIFC3.
GenomeRNAi3801.
NextBio14931.
PROQ9BVG8.
SOURCESearch...

Entry information

Entry nameKIFC3_HUMAN
AccessionPrimary (citable) accession number: Q9BVG8
Secondary accession number(s): A8K6S2 expand/collapse secondary AC list , O75299, Q49A29, Q49AQ0, Q59G19, Q8IUT3, Q96HW6
Entry history
Integrated into UniProtKB/Swiss-Prot: August 15, 2003
Last sequence update: November 16, 2011
Last modified: April 16, 2014
This is version 120 of the entry and version 4 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 16

Human chromosome 16: entries, gene names and cross-references to MIM