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Q9BVC6

- TM109_HUMAN

UniProt

Q9BVC6 - TM109_HUMAN

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Protein

Transmembrane protein 109

Gene
TMEM109
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

GO - Biological processi

  1. cellular response to gamma radiation Source: MGI
  2. intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator Source: Ensembl
  3. negative regulation of cell death Source: MGI
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Transmembrane protein 109
Alternative name(s):
Mitsugumin-23
Short name:
Mg23
Gene namesi
Name:TMEM109
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 11

Organism-specific databases

HGNCiHGNC:28771. TMEM109.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei84 – 10421Helical; Reviewed predictionAdd
BLAST
Transmembranei136 – 15621Helical; Reviewed predictionAdd
BLAST
Transmembranei159 – 17921Helical; Reviewed predictionAdd
BLAST
Transmembranei186 – 20520Helical; Reviewed predictionAdd
BLAST

GO - Cellular componenti

  1. extracellular vesicular exosome Source: UniProt
  2. integral component of membrane Source: UniProtKB-KW
  3. nuclear outer membrane Source: UniProtKB-SubCell
  4. sarcoplasmic reticulum membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane, Nucleus, Sarcoplasmic reticulum

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA142670760.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 3333 Reviewed predictionAdd
BLAST
Chaini34 – 243210Transmembrane protein 109PRO_0000044618Add
BLAST

Proteomic databases

MaxQBiQ9BVC6.
PaxDbiQ9BVC6.
PeptideAtlasiQ9BVC6.
PRIDEiQ9BVC6.

PTM databases

PhosphoSiteiQ9BVC6.

Expressioni

Gene expression databases

ArrayExpressiQ9BVC6.
BgeeiQ9BVC6.
CleanExiHS_TMEM109.
GenevestigatoriQ9BVC6.

Organism-specific databases

HPAiHPA011785.

Interactioni

Protein-protein interaction databases

BioGridi122524. 3 interactions.
IntActiQ9BVC6. 6 interactions.
MINTiMINT-5003515.
STRINGi9606.ENSP00000227525.

Structurei

3D structure databases

ProteinModelPortaliQ9BVC6.

Family & Domainsi

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG46846.
HOGENOMiHOG000126892.
HOVERGENiHBG083664.
InParanoidiQ9BVC6.
OMAiTMHLVSE.
OrthoDBiEOG79CZ16.
PhylomeDBiQ9BVC6.
TreeFamiTF332238.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9BVC6-1 [UniParc]FASTAAdd to Basket

« Hide

MAASSISSPW GKHVFKAILM VLVALILLHS ALAQSRRDFA PPGQQKREAP    50
VDVLTQIGRS VRGTLDAWIG PETMHLVSES SSQVLWAISS AISVAFFALS 100
GIAAQLLNAL GLAGDYLAQG LKLSPGQVQT FLLWGAGALV VYWLLSLLLG 150
LVLALLGRIL WGLKLVIFLA GFVALMRSVP DPSTRALLLL ALLILYALLS 200
RLTGSRASGA QLEAKVRGLE RQVEELRWRQ RRAAKGARSV EEE 243
Length:243
Mass (Da):26,210
Last modified:June 1, 2001 - v1
Checksum:iE405591236B94BB3
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC001309 mRNA. Translation: AAH01309.1.
CCDSiCCDS7996.1.
RefSeqiNP_076997.1. NM_024092.2.
UniGeneiHs.13662.

Genome annotation databases

EnsembliENST00000227525; ENSP00000227525; ENSG00000110108.
ENST00000536171; ENSP00000443990; ENSG00000110108.
GeneIDi79073.
KEGGihsa:79073.
UCSCiuc001nqg.3. human.

Polymorphism databases

DMDMi74733312.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC001309 mRNA. Translation: AAH01309.1 .
CCDSi CCDS7996.1.
RefSeqi NP_076997.1. NM_024092.2.
UniGenei Hs.13662.

3D structure databases

ProteinModelPortali Q9BVC6.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 122524. 3 interactions.
IntActi Q9BVC6. 6 interactions.
MINTi MINT-5003515.
STRINGi 9606.ENSP00000227525.

PTM databases

PhosphoSitei Q9BVC6.

Polymorphism databases

DMDMi 74733312.

Proteomic databases

MaxQBi Q9BVC6.
PaxDbi Q9BVC6.
PeptideAtlasi Q9BVC6.
PRIDEi Q9BVC6.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000227525 ; ENSP00000227525 ; ENSG00000110108 .
ENST00000536171 ; ENSP00000443990 ; ENSG00000110108 .
GeneIDi 79073.
KEGGi hsa:79073.
UCSCi uc001nqg.3. human.

Organism-specific databases

CTDi 79073.
GeneCardsi GC11P060681.
HGNCi HGNC:28771. TMEM109.
HPAi HPA011785.
neXtProti NX_Q9BVC6.
PharmGKBi PA142670760.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG46846.
HOGENOMi HOG000126892.
HOVERGENi HBG083664.
InParanoidi Q9BVC6.
OMAi TMHLVSE.
OrthoDBi EOG79CZ16.
PhylomeDBi Q9BVC6.
TreeFami TF332238.

Miscellaneous databases

GenomeRNAii 79073.
NextBioi 67865.
PROi Q9BVC6.

Gene expression databases

ArrayExpressi Q9BVC6.
Bgeei Q9BVC6.
CleanExi HS_TMEM109.
Genevestigatori Q9BVC6.

Family and domain databases

ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Placenta.
  2. Bienvenut W.V., Claeys D.
    Submitted (NOV-2005) to UniProtKB
    Cited for: PROTEIN SEQUENCE OF 48-59 AND 207-215, IDENTIFICATION BY MASS SPECTROMETRY.
    Tissue: Platelet.
  3. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiTM109_HUMAN
AccessioniPrimary (citable) accession number: Q9BVC6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 20, 2005
Last sequence update: June 1, 2001
Last modified: July 9, 2014
This is version 88 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM

External Data

Dasty 3

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