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Protein

Transmembrane protein 109

Gene

TMEM109

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

May mediate cellular response to DNA damage by protecting against ultraviolet C-induced cell death (PubMed:23542032). Can form voltage-gated calcium and potassium channels in vitro (By similarity).By similarity1 Publication

GO - Molecular functioni

GO - Biological processi

  • cellular response to gamma radiation Source: MGI
  • intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator Source: Ensembl
  • negative regulation of cell death Source: MGI

Keywordsi

Molecular functionIon channel, Voltage-gated channel
Biological processIon transport, Transport

Protein family/group databases

TCDBi1.A.74.1.2. the mitsugumin 23 (mg23) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Transmembrane protein 109
Alternative name(s):
Mitsugumin-23
Short name:
Mg23
Gene namesi
Name:TMEM109
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

EuPathDBiHostDB:ENSG00000110108.9.
HGNCiHGNC:28771. TMEM109.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini34 – 83LumenalBy similarityAdd BLAST50
Transmembranei84 – 104HelicalSequence analysisAdd BLAST21
Topological domaini105 – 135CytoplasmicBy similarityAdd BLAST31
Transmembranei136 – 156HelicalSequence analysisAdd BLAST21
Topological domaini157 – 185LumenalBy similarityAdd BLAST29
Transmembranei186 – 205HelicalSequence analysisAdd BLAST20
Topological domaini206 – 243CytoplasmicBy similarityAdd BLAST38

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane, Nucleus, Sarcoplasmic reticulum

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000110108.
PharmGKBiPA142670760.

Polymorphism and mutation databases

BioMutaiTMEM109.
DMDMi74733312.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 33Sequence analysisAdd BLAST33
ChainiPRO_000004461834 – 243Transmembrane protein 109Add BLAST210

Proteomic databases

EPDiQ9BVC6.
MaxQBiQ9BVC6.
PaxDbiQ9BVC6.
PeptideAtlasiQ9BVC6.
PRIDEiQ9BVC6.
TopDownProteomicsiQ9BVC6.

PTM databases

iPTMnetiQ9BVC6.
PhosphoSitePlusiQ9BVC6.
SwissPalmiQ9BVC6.

Expressioni

Gene expression databases

BgeeiENSG00000110108.
CleanExiHS_TMEM109.
GenevisibleiQ9BVC6. HS.

Organism-specific databases

HPAiHPA011785.

Interactioni

Subunit structurei

Homooligomer (By similarity). Interacts with CRYAB (PubMed:23542032).By similarity1 Publication

Protein-protein interaction databases

BioGridi122524. 18 interactors.
IntActiQ9BVC6. 25 interactors.
MINTiMINT-5003515.

Structurei

3D structure databases

ProteinModelPortaliQ9BVC6.
SMRiQ9BVC6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IIBB. Eukaryota.
ENOG410XXDM. LUCA.
GeneTreeiENSGT00390000015704.
HOGENOMiHOG000126892.
HOVERGENiHBG083664.
InParanoidiQ9BVC6.
OMAiPGQVQTF.
OrthoDBiEOG091G0S01.
PhylomeDBiQ9BVC6.
TreeFamiTF332238.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9BVC6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAASSISSPW GKHVFKAILM VLVALILLHS ALAQSRRDFA PPGQQKREAP
60 70 80 90 100
VDVLTQIGRS VRGTLDAWIG PETMHLVSES SSQVLWAISS AISVAFFALS
110 120 130 140 150
GIAAQLLNAL GLAGDYLAQG LKLSPGQVQT FLLWGAGALV VYWLLSLLLG
160 170 180 190 200
LVLALLGRIL WGLKLVIFLA GFVALMRSVP DPSTRALLLL ALLILYALLS
210 220 230 240
RLTGSRASGA QLEAKVRGLE RQVEELRWRQ RRAAKGARSV EEE
Length:243
Mass (Da):26,210
Last modified:June 1, 2001 - v1
Checksum:iE405591236B94BB3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC001309 mRNA. Translation: AAH01309.1.
CCDSiCCDS7996.1.
RefSeqiNP_076997.1. NM_024092.2.
UniGeneiHs.13662.

Genome annotation databases

EnsembliENST00000227525; ENSP00000227525; ENSG00000110108.
ENST00000536171; ENSP00000443990; ENSG00000110108.
GeneIDi79073.
KEGGihsa:79073.
UCSCiuc001nqg.4. human.

Similar proteinsi

Entry informationi

Entry nameiTM109_HUMAN
AccessioniPrimary (citable) accession number: Q9BVC6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 20, 2005
Last sequence update: June 1, 2001
Last modified: October 25, 2017
This is version 115 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM