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Protein

Transmembrane protein 109

Gene

TMEM109

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

GO - Biological processi

  1. cellular response to gamma radiation Source: MGI
  2. intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator Source: Ensembl
  3. negative regulation of cell death Source: MGI
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Transmembrane protein 109
Alternative name(s):
Mitsugumin-23
Short name:
Mg23
Gene namesi
Name:TMEM109
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 11

Organism-specific databases

HGNCiHGNC:28771. TMEM109.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei84 – 10421HelicalSequence AnalysisAdd
BLAST
Transmembranei136 – 15621HelicalSequence AnalysisAdd
BLAST
Transmembranei159 – 17921HelicalSequence AnalysisAdd
BLAST
Transmembranei186 – 20520HelicalSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. extracellular vesicular exosome Source: UniProtKB
  2. integral component of membrane Source: UniProtKB-KW
  3. nuclear outer membrane Source: UniProtKB-SubCell
  4. sarcoplasmic reticulum membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane, Nucleus, Sarcoplasmic reticulum

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA142670760.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 3333Sequence AnalysisAdd
BLAST
Chaini34 – 243210Transmembrane protein 109PRO_0000044618Add
BLAST

Proteomic databases

MaxQBiQ9BVC6.
PaxDbiQ9BVC6.
PeptideAtlasiQ9BVC6.
PRIDEiQ9BVC6.

PTM databases

PhosphoSiteiQ9BVC6.

Expressioni

Gene expression databases

BgeeiQ9BVC6.
CleanExiHS_TMEM109.
GenevestigatoriQ9BVC6.

Organism-specific databases

HPAiHPA011785.

Interactioni

Protein-protein interaction databases

BioGridi122524. 4 interactions.
IntActiQ9BVC6. 6 interactions.
MINTiMINT-5003515.
STRINGi9606.ENSP00000227525.

Structurei

3D structure databases

ProteinModelPortaliQ9BVC6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG46846.
GeneTreeiENSGT00390000015704.
HOGENOMiHOG000126892.
HOVERGENiHBG083664.
InParanoidiQ9BVC6.
OMAiPGQVQTF.
OrthoDBiEOG79CZ16.
PhylomeDBiQ9BVC6.
TreeFamiTF332238.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9BVC6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAASSISSPW GKHVFKAILM VLVALILLHS ALAQSRRDFA PPGQQKREAP
60 70 80 90 100
VDVLTQIGRS VRGTLDAWIG PETMHLVSES SSQVLWAISS AISVAFFALS
110 120 130 140 150
GIAAQLLNAL GLAGDYLAQG LKLSPGQVQT FLLWGAGALV VYWLLSLLLG
160 170 180 190 200
LVLALLGRIL WGLKLVIFLA GFVALMRSVP DPSTRALLLL ALLILYALLS
210 220 230 240
RLTGSRASGA QLEAKVRGLE RQVEELRWRQ RRAAKGARSV EEE
Length:243
Mass (Da):26,210
Last modified:June 1, 2001 - v1
Checksum:iE405591236B94BB3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC001309 mRNA. Translation: AAH01309.1.
CCDSiCCDS7996.1.
RefSeqiNP_076997.1. NM_024092.2.
UniGeneiHs.13662.

Genome annotation databases

EnsembliENST00000227525; ENSP00000227525; ENSG00000110108.
ENST00000536171; ENSP00000443990; ENSG00000110108.
GeneIDi79073.
KEGGihsa:79073.
UCSCiuc001nqg.3. human.

Polymorphism databases

DMDMi74733312.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC001309 mRNA. Translation: AAH01309.1.
CCDSiCCDS7996.1.
RefSeqiNP_076997.1. NM_024092.2.
UniGeneiHs.13662.

3D structure databases

ProteinModelPortaliQ9BVC6.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi122524. 4 interactions.
IntActiQ9BVC6. 6 interactions.
MINTiMINT-5003515.
STRINGi9606.ENSP00000227525.

PTM databases

PhosphoSiteiQ9BVC6.

Polymorphism databases

DMDMi74733312.

Proteomic databases

MaxQBiQ9BVC6.
PaxDbiQ9BVC6.
PeptideAtlasiQ9BVC6.
PRIDEiQ9BVC6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000227525; ENSP00000227525; ENSG00000110108.
ENST00000536171; ENSP00000443990; ENSG00000110108.
GeneIDi79073.
KEGGihsa:79073.
UCSCiuc001nqg.3. human.

Organism-specific databases

CTDi79073.
GeneCardsiGC11P060681.
HGNCiHGNC:28771. TMEM109.
HPAiHPA011785.
neXtProtiNX_Q9BVC6.
PharmGKBiPA142670760.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG46846.
GeneTreeiENSGT00390000015704.
HOGENOMiHOG000126892.
HOVERGENiHBG083664.
InParanoidiQ9BVC6.
OMAiPGQVQTF.
OrthoDBiEOG79CZ16.
PhylomeDBiQ9BVC6.
TreeFamiTF332238.

Miscellaneous databases

ChiTaRSiTMEM109. human.
GenomeRNAii79073.
NextBioi67865.
PROiQ9BVC6.

Gene expression databases

BgeeiQ9BVC6.
CleanExiHS_TMEM109.
GenevestigatoriQ9BVC6.

Family and domain databases

ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Placenta.
  2. Bienvenut W.V., Claeys D.
    Submitted (OCT-2005) to UniProtKB
    Cited for: PROTEIN SEQUENCE OF 48-59 AND 207-215, IDENTIFICATION BY MASS SPECTROMETRY.
    Tissue: Platelet.
  3. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiTM109_HUMAN
AccessioniPrimary (citable) accession number: Q9BVC6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 20, 2005
Last sequence update: June 1, 2001
Last modified: January 7, 2015
This is version 92 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.