Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Transmembrane protein 109

Gene

TMEM109

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

May mediate cellular response to DNA damage by protecting against ultraviolet C-induced cell death (PubMed:23542032). Can form voltage-gated calcium and potassium channels in vitro (By similarity).By similarity1 Publication

GO - Molecular functioni

GO - Biological processi

  • cellular response to gamma radiation Source: MGI
  • intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator Source: Ensembl
  • negative regulation of cell death Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Ion channel, Voltage-gated channel

Keywords - Biological processi

Ion transport, Transport

Enzyme and pathway databases

BioCyciZFISH:ENSG00000110108-MONOMER.

Protein family/group databases

TCDBi1.A.74.1.2. the mitsugumin 23 (mg23) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Transmembrane protein 109
Alternative name(s):
Mitsugumin-23
Short name:
Mg23
Gene namesi
Name:TMEM109
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

HGNCiHGNC:28771. TMEM109.

Subcellular locationi

  • Nucleus outer membrane By similarity; Multi-pass membrane protein By similarity
  • Endoplasmic reticulum membrane By similarity; Multi-pass membrane protein By similarity
  • Sarcoplasmic reticulum membrane By similarity; Multi-pass membrane protein By similarity

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini34 – 83LumenalBy similarityAdd BLAST50
Transmembranei84 – 104HelicalSequence analysisAdd BLAST21
Topological domaini105 – 135CytoplasmicBy similarityAdd BLAST31
Transmembranei136 – 156HelicalSequence analysisAdd BLAST21
Topological domaini157 – 185LumenalBy similarityAdd BLAST29
Transmembranei186 – 205HelicalSequence analysisAdd BLAST20
Topological domaini206 – 243CytoplasmicBy similarityAdd BLAST38

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane, Nucleus, Sarcoplasmic reticulum

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000110108.
PharmGKBiPA142670760.

Polymorphism and mutation databases

BioMutaiTMEM109.
DMDMi74733312.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 33Sequence analysisAdd BLAST33
ChainiPRO_000004461834 – 243Transmembrane protein 109Add BLAST210

Proteomic databases

EPDiQ9BVC6.
MaxQBiQ9BVC6.
PaxDbiQ9BVC6.
PeptideAtlasiQ9BVC6.
PRIDEiQ9BVC6.
TopDownProteomicsiQ9BVC6.

PTM databases

iPTMnetiQ9BVC6.
PhosphoSitePlusiQ9BVC6.
SwissPalmiQ9BVC6.

Expressioni

Gene expression databases

BgeeiENSG00000110108.
CleanExiHS_TMEM109.
GenevisibleiQ9BVC6. HS.

Organism-specific databases

HPAiHPA011785.

Interactioni

Subunit structurei

Homooligomer (By similarity). Interacts with CRYAB (PubMed:23542032).By similarity1 Publication

Protein-protein interaction databases

BioGridi122524. 17 interactors.
IntActiQ9BVC6. 24 interactors.
MINTiMINT-5003515.
STRINGi9606.ENSP00000227525.

Structurei

3D structure databases

ProteinModelPortaliQ9BVC6.
SMRiQ9BVC6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IIBB. Eukaryota.
ENOG410XXDM. LUCA.
GeneTreeiENSGT00390000015704.
HOGENOMiHOG000126892.
HOVERGENiHBG083664.
InParanoidiQ9BVC6.
OMAiPGQVQTF.
OrthoDBiEOG091G0S01.
PhylomeDBiQ9BVC6.
TreeFamiTF332238.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9BVC6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAASSISSPW GKHVFKAILM VLVALILLHS ALAQSRRDFA PPGQQKREAP
60 70 80 90 100
VDVLTQIGRS VRGTLDAWIG PETMHLVSES SSQVLWAISS AISVAFFALS
110 120 130 140 150
GIAAQLLNAL GLAGDYLAQG LKLSPGQVQT FLLWGAGALV VYWLLSLLLG
160 170 180 190 200
LVLALLGRIL WGLKLVIFLA GFVALMRSVP DPSTRALLLL ALLILYALLS
210 220 230 240
RLTGSRASGA QLEAKVRGLE RQVEELRWRQ RRAAKGARSV EEE
Length:243
Mass (Da):26,210
Last modified:June 1, 2001 - v1
Checksum:iE405591236B94BB3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC001309 mRNA. Translation: AAH01309.1.
CCDSiCCDS7996.1.
RefSeqiNP_076997.1. NM_024092.2.
UniGeneiHs.13662.

Genome annotation databases

EnsembliENST00000227525; ENSP00000227525; ENSG00000110108.
ENST00000536171; ENSP00000443990; ENSG00000110108.
GeneIDi79073.
KEGGihsa:79073.
UCSCiuc001nqg.4. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC001309 mRNA. Translation: AAH01309.1.
CCDSiCCDS7996.1.
RefSeqiNP_076997.1. NM_024092.2.
UniGeneiHs.13662.

3D structure databases

ProteinModelPortaliQ9BVC6.
SMRiQ9BVC6.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi122524. 17 interactors.
IntActiQ9BVC6. 24 interactors.
MINTiMINT-5003515.
STRINGi9606.ENSP00000227525.

Protein family/group databases

TCDBi1.A.74.1.2. the mitsugumin 23 (mg23) family.

PTM databases

iPTMnetiQ9BVC6.
PhosphoSitePlusiQ9BVC6.
SwissPalmiQ9BVC6.

Polymorphism and mutation databases

BioMutaiTMEM109.
DMDMi74733312.

Proteomic databases

EPDiQ9BVC6.
MaxQBiQ9BVC6.
PaxDbiQ9BVC6.
PeptideAtlasiQ9BVC6.
PRIDEiQ9BVC6.
TopDownProteomicsiQ9BVC6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000227525; ENSP00000227525; ENSG00000110108.
ENST00000536171; ENSP00000443990; ENSG00000110108.
GeneIDi79073.
KEGGihsa:79073.
UCSCiuc001nqg.4. human.

Organism-specific databases

CTDi79073.
GeneCardsiTMEM109.
HGNCiHGNC:28771. TMEM109.
HPAiHPA011785.
neXtProtiNX_Q9BVC6.
OpenTargetsiENSG00000110108.
PharmGKBiPA142670760.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IIBB. Eukaryota.
ENOG410XXDM. LUCA.
GeneTreeiENSGT00390000015704.
HOGENOMiHOG000126892.
HOVERGENiHBG083664.
InParanoidiQ9BVC6.
OMAiPGQVQTF.
OrthoDBiEOG091G0S01.
PhylomeDBiQ9BVC6.
TreeFamiTF332238.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000110108-MONOMER.

Miscellaneous databases

ChiTaRSiTMEM109. human.
GenomeRNAii79073.
PROiQ9BVC6.

Gene expression databases

BgeeiENSG00000110108.
CleanExiHS_TMEM109.
GenevisibleiQ9BVC6. HS.

Family and domain databases

ProtoNetiSearch...

Entry informationi

Entry nameiTM109_HUMAN
AccessioniPrimary (citable) accession number: Q9BVC6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 20, 2005
Last sequence update: June 1, 2001
Last modified: November 2, 2016
This is version 108 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.