Q9BVC6 (TM109_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Transmembrane protein 109

Alternative name(s):
Mitsugumin-23
Short name=Mg23

Gene names

Name:

TMEM109

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	243 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Subcellular location

Nucleus outer membrane; Multi-pass membrane protein By similarity. Endoplasmic reticulum membrane; Multi-pass membrane protein By similarity. Sarcoplasmic reticulum membrane; Multi-pass membrane protein By similarity.

Ontologies

Keywords
Cellular component	Endoplasmic reticulum Membrane Nucleus Sarcoplasmic reticulum
Domain	Signal Transmembrane Transmembrane helix
Technical term	Complete proteome Direct protein sequencing Reference proteome
Gene Ontology (GO)
Biological_process	intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator Inferred from electronic annotation. Source: Compara
Cellular_component	cytoplasm Inferred from direct assay. Source: HPA integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW nuclear membrane Inferred from direct assay. Source: HPA nuclear outer membrane Inferred from electronic annotation. Source: UniProtKB-SubCell sarcoplasmic reticulum membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 33	33	Potential
	Chain	34 – 243	210	Transmembrane protein 109		PRO_0000044618
Regions
	Transmembrane	84 – 104	21	Helical; Potential
	Transmembrane	136 – 156	21	Helical; Potential
	Transmembrane	159 – 179	21	Helical; Potential
	Transmembrane	186 – 205	20	Helical; Potential

Sequences

	Sequence		Length	Mass (Da)
	Q9BVC6 [UniParc]. Last modified June 1, 2001. Version 1. Checksum: E405591236B94BB3	FASTA	243	26,210
	10 20 30 40 50 60 MAASSISSPW GKHVFKAILM VLVALILLHS ALAQSRRDFA PPGQQKREAP VDVLTQIGRS 70 80 90 100 110 120 VRGTLDAWIG PETMHLVSES SSQVLWAISS AISVAFFALS GIAAQLLNAL GLAGDYLAQG 130 140 150 160 170 180 LKLSPGQVQT FLLWGAGALV VYWLLSLLLG LVLALLGRIL WGLKLVIFLA GFVALMRSVP 190 200 210 220 230 240 DPSTRALLLL ALLILYALLS RLTGSRASGA QLEAKVRGLE RQVEELRWRQ RRAAKGARSV EEE

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Placenta.
[2]	Bienvenut W.V., Claeys D. Submitted (NOV-2005) to UniProtKB Cited for: PROTEIN SEQUENCE OF 48-59 AND 207-215, MASS SPECTROMETRY. Tissue: Platelet.
[3]	"Initial characterization of the human central proteome." Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J. BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BC001309 mRNA. Translation: AAH01309.1.
IPI	IPI00031697.
RefSeq	NP_076997.1. NM_024092.2.
UniGene	Hs.13662.
3D structure databases
ProteinModelPortal	Q9BVC6.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q9BVC6. 6 interactions.
STRING	9606.ENSP00000227525.
PTM databases
PhosphoSite	Q9BVC6.
Polymorphism databases
DMDM	74733312.
Proteomic databases
PaxDb	Q9BVC6.
PeptideAtlas	Q9BVC6.
PRIDE	Q9BVC6.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000227525; ENSP00000227525; ENSG00000110108. ENST00000536171; ENSP00000443990; ENSG00000110108.
GeneID	79073.
KEGG	hsa:79073.
UCSC	uc001nqg.3. human.
Organism-specific databases
CTD	79073.
GeneCards	GC11P060681.
HGNC	HGNC:28771. TMEM109.
HPA	HPA011785.
neXtProt	NX_Q9BVC6.
PharmGKB	PA142670760.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG46846.
HOGENOM	HOG000126892.
HOVERGEN	HBG083664.
InParanoid	Q9BVC6.
OMA	MWAISSA.
PhylomeDB	Q9BVC6.
Gene expression databases
ArrayExpress	Q9BVC6.
Bgee	Q9BVC6.
CleanEx	HS_TMEM109.
Genevestigator	Q9BVC6.
GermOnline	ENSG00000110108. Homo sapiens.
Family and domain databases
ProtoNet	Search...
Other
GenomeRNAi	79073.
NextBio	67865.

Entry information

Entry name

TM109_HUMAN

Accession

Primary (citable) accession number: Q9BVC6

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 20, 2005
Last sequence update:	June 1, 2001
Last modified:	April 3, 2013
This is version 77 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.