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Q9BVC6

- TM109_HUMAN

UniProt

Q9BVC6 - TM109_HUMAN

Protein

Transmembrane protein 109

Gene

TMEM109

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 89 (01 Oct 2014)
      Sequence version 1 (01 Jun 2001)
      Previous versions | rss
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    Functioni

    GO - Biological processi

    1. cellular response to gamma radiation Source: MGI
    2. intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator Source: Ensembl
    3. negative regulation of cell death Source: MGI

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Transmembrane protein 109
    Alternative name(s):
    Mitsugumin-23
    Short name:
    Mg23
    Gene namesi
    Name:TMEM109
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 11

    Organism-specific databases

    HGNCiHGNC:28771. TMEM109.

    Subcellular locationi

    GO - Cellular componenti

    1. extracellular vesicular exosome Source: UniProt
    2. integral component of membrane Source: UniProtKB-KW
    3. nuclear outer membrane Source: UniProtKB-SubCell
    4. sarcoplasmic reticulum membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Endoplasmic reticulum, Membrane, Nucleus, Sarcoplasmic reticulum

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA142670760.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 3333Sequence AnalysisAdd
    BLAST
    Chaini34 – 243210Transmembrane protein 109PRO_0000044618Add
    BLAST

    Proteomic databases

    MaxQBiQ9BVC6.
    PaxDbiQ9BVC6.
    PeptideAtlasiQ9BVC6.
    PRIDEiQ9BVC6.

    PTM databases

    PhosphoSiteiQ9BVC6.

    Expressioni

    Gene expression databases

    ArrayExpressiQ9BVC6.
    BgeeiQ9BVC6.
    CleanExiHS_TMEM109.
    GenevestigatoriQ9BVC6.

    Organism-specific databases

    HPAiHPA011785.

    Interactioni

    Protein-protein interaction databases

    BioGridi122524. 3 interactions.
    IntActiQ9BVC6. 6 interactions.
    MINTiMINT-5003515.
    STRINGi9606.ENSP00000227525.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9BVC6.
    ModBaseiSearch...
    MobiDBiSearch...

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei84 – 10421HelicalSequence AnalysisAdd
    BLAST
    Transmembranei136 – 15621HelicalSequence AnalysisAdd
    BLAST
    Transmembranei159 – 17921HelicalSequence AnalysisAdd
    BLAST
    Transmembranei186 – 20520HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Keywords - Domaini

    Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG46846.
    HOGENOMiHOG000126892.
    HOVERGENiHBG083664.
    InParanoidiQ9BVC6.
    OMAiTMHLVSE.
    OrthoDBiEOG79CZ16.
    PhylomeDBiQ9BVC6.
    TreeFamiTF332238.

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q9BVC6-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAASSISSPW GKHVFKAILM VLVALILLHS ALAQSRRDFA PPGQQKREAP    50
    VDVLTQIGRS VRGTLDAWIG PETMHLVSES SSQVLWAISS AISVAFFALS 100
    GIAAQLLNAL GLAGDYLAQG LKLSPGQVQT FLLWGAGALV VYWLLSLLLG 150
    LVLALLGRIL WGLKLVIFLA GFVALMRSVP DPSTRALLLL ALLILYALLS 200
    RLTGSRASGA QLEAKVRGLE RQVEELRWRQ RRAAKGARSV EEE 243
    Length:243
    Mass (Da):26,210
    Last modified:June 1, 2001 - v1
    Checksum:iE405591236B94BB3
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC001309 mRNA. Translation: AAH01309.1.
    CCDSiCCDS7996.1.
    RefSeqiNP_076997.1. NM_024092.2.
    UniGeneiHs.13662.

    Genome annotation databases

    EnsembliENST00000227525; ENSP00000227525; ENSG00000110108.
    ENST00000536171; ENSP00000443990; ENSG00000110108.
    GeneIDi79073.
    KEGGihsa:79073.
    UCSCiuc001nqg.3. human.

    Polymorphism databases

    DMDMi74733312.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC001309 mRNA. Translation: AAH01309.1 .
    CCDSi CCDS7996.1.
    RefSeqi NP_076997.1. NM_024092.2.
    UniGenei Hs.13662.

    3D structure databases

    ProteinModelPortali Q9BVC6.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 122524. 3 interactions.
    IntActi Q9BVC6. 6 interactions.
    MINTi MINT-5003515.
    STRINGi 9606.ENSP00000227525.

    PTM databases

    PhosphoSitei Q9BVC6.

    Polymorphism databases

    DMDMi 74733312.

    Proteomic databases

    MaxQBi Q9BVC6.
    PaxDbi Q9BVC6.
    PeptideAtlasi Q9BVC6.
    PRIDEi Q9BVC6.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000227525 ; ENSP00000227525 ; ENSG00000110108 .
    ENST00000536171 ; ENSP00000443990 ; ENSG00000110108 .
    GeneIDi 79073.
    KEGGi hsa:79073.
    UCSCi uc001nqg.3. human.

    Organism-specific databases

    CTDi 79073.
    GeneCardsi GC11P060681.
    HGNCi HGNC:28771. TMEM109.
    HPAi HPA011785.
    neXtProti NX_Q9BVC6.
    PharmGKBi PA142670760.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG46846.
    HOGENOMi HOG000126892.
    HOVERGENi HBG083664.
    InParanoidi Q9BVC6.
    OMAi TMHLVSE.
    OrthoDBi EOG79CZ16.
    PhylomeDBi Q9BVC6.
    TreeFami TF332238.

    Miscellaneous databases

    GenomeRNAii 79073.
    NextBioi 67865.
    PROi Q9BVC6.

    Gene expression databases

    ArrayExpressi Q9BVC6.
    Bgeei Q9BVC6.
    CleanExi HS_TMEM109.
    Genevestigatori Q9BVC6.

    Family and domain databases

    ProtoNeti Search...

    Publicationsi

    1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Placenta.
    2. Bienvenut W.V., Claeys D.
      Submitted (NOV-2005) to UniProtKB
      Cited for: PROTEIN SEQUENCE OF 48-59 AND 207-215, IDENTIFICATION BY MASS SPECTROMETRY.
      Tissue: Platelet.
    3. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiTM109_HUMAN
    AccessioniPrimary (citable) accession number: Q9BVC6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 20, 2005
    Last sequence update: June 1, 2001
    Last modified: October 1, 2014
    This is version 89 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. Human chromosome 11
      Human chromosome 11: entries, gene names and cross-references to MIM

    External Data

    Dasty 3