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Protein

Sister chromatid cohesion protein DCC1

Gene

DSCC1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Loads PCNA onto primed templates regulating velocity, spacing and restart activity of replication forks. May couple DNA replication to sister chromatid cohesion through regulation of the acetylation of the cohesin subunit SMC3.2 Publications

GO - Molecular functioni

GO - Biological processi

  • DNA replication Source: UniProtKB-KW
  • maintenance of mitotic sister chromatid cohesion Source: UniProtKB
  • post-translational protein acetylation Source: UniProtKB
  • regulation of DNA replication Source: UniProtKB
Complete GO annotation...

Keywords - Biological processi

Cell cycle, DNA replication

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Sister chromatid cohesion protein DCC1
Alternative name(s):
Defective in sister chromatid cohesion protein 1 homolog
Gene namesi
Name:DSCC1
Synonyms:DCC1
ORF Names:UNQ9337/PRO34008
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 8

Organism-specific databases

HGNCiHGNC:24453. DSCC1.

Subcellular locationi

GO - Cellular componenti

  • chromatin Source: UniProtKB
  • chromosome, centromeric region Source: UniProtKB
  • Ctf18 RFC-like complex Source: GO_Central
  • nucleoplasm Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA162384079.

Polymorphism and mutation databases

BioMutaiDSCC1.
DMDMi167012058.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 393393Sister chromatid cohesion protein DCC1PRO_0000318064Add
BLAST

Proteomic databases

MaxQBiQ9BVC3.
PaxDbiQ9BVC3.
PRIDEiQ9BVC3.

PTM databases

PhosphoSiteiQ9BVC3.

Expressioni

Gene expression databases

BgeeiQ9BVC3.
CleanExiHS_DSCC1.
GenevisibleiQ9BVC3. HS.

Organism-specific databases

HPAiHPA023780.
HPA024401.

Interactioni

Subunit structurei

Component of the CTF18-RFC complex which consists of CTF8, CTF18, DSCC1 and the RFC complex. Interacts with CTF8 and CTF18.1 Publication

Protein-protein interaction databases

BioGridi122526. 13 interactions.
STRINGi9606.ENSP00000322180.

Structurei

3D structure databases

ProteinModelPortaliQ9BVC3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the DCC1 family.Curated

Phylogenomic databases

eggNOGiNOG250437.
GeneTreeiENSGT00390000017400.
HOGENOMiHOG000008115.
HOVERGENiHBG105358.
InParanoidiQ9BVC3.
KOiK11271.
OMAiGMTTRLD.
OrthoDBiEOG7M6D7D.
PhylomeDBiQ9BVC3.
TreeFamiTF106104.

Family and domain databases

InterProiIPR019128. Sister_chromatid_cohesion_Dcc1.
[Graphical view]
PfamiPF09724. DUF2036. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9BVC3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKRTRDEVDA TLQIAKLNAA ELLPAVHCLG FGPGASGAAA GDFCLLELEP
60 70 80 90 100
TLCQQLEDGH SLVIRGDKDE QAVLCSKDKT YDLKIADTSN MLLFIPGCKT
110 120 130 140 150
PDQLKKEDSH CNIIHTEIFG FSNNYWELRR RRPKLKKLKK LLMENPYEGP
160 170 180 190 200
DSQKEKDSNS SKYTTEDLLD QIQASEEEIM TQLQVLNACK IGGYWRILEF
210 220 230 240 250
DYEMKLLNHV TQLVDSESWS FGKVPLNTCL QELGPLEPEE MIEHCLKCYG
260 270 280 290 300
KKYVDEGEVY FELDADKICR AAARMLLQNA VKFNLAEFQE VWQQSVPEGM
310 320 330 340 350
VTSLDQLKGL ALVDRHSRPE IIFLLKVDDL PEDNQERFNS LFSLREKWTE
360 370 380 390
EDIAPYIQDL CGEKQTIGAL LTKYSHSSMQ NGVKVYNSRR PIS
Length:393
Mass (Da):44,825
Last modified:February 5, 2008 - v2
Checksum:iAAF6C66B7151FA65
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti376 – 3761H → R.2 Publications
Corresponds to variant rs1055130 [ dbSNP | Ensembl ].
VAR_038682

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY358866 mRNA. Translation: AAQ89225.1.
AK054585 mRNA. Translation: BAB70767.1.
BC001316 mRNA. Translation: AAH01316.1.
BC001531 mRNA. Translation: AAH01531.1.
CCDSiCCDS6330.1.
RefSeqiNP_076999.2. NM_024094.2.
UniGeneiHs.315167.

Genome annotation databases

EnsembliENST00000313655; ENSP00000322180; ENSG00000136982.
GeneIDi79075.
KEGGihsa:79075.
UCSCiuc003yov.3. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY358866 mRNA. Translation: AAQ89225.1.
AK054585 mRNA. Translation: BAB70767.1.
BC001316 mRNA. Translation: AAH01316.1.
BC001531 mRNA. Translation: AAH01531.1.
CCDSiCCDS6330.1.
RefSeqiNP_076999.2. NM_024094.2.
UniGeneiHs.315167.

3D structure databases

ProteinModelPortaliQ9BVC3.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi122526. 13 interactions.
STRINGi9606.ENSP00000322180.

PTM databases

PhosphoSiteiQ9BVC3.

Polymorphism and mutation databases

BioMutaiDSCC1.
DMDMi167012058.

Proteomic databases

MaxQBiQ9BVC3.
PaxDbiQ9BVC3.
PRIDEiQ9BVC3.

Protocols and materials databases

DNASUi79075.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000313655; ENSP00000322180; ENSG00000136982.
GeneIDi79075.
KEGGihsa:79075.
UCSCiuc003yov.3. human.

Organism-specific databases

CTDi79075.
GeneCardsiGC08M120846.
HGNCiHGNC:24453. DSCC1.
HPAiHPA023780.
HPA024401.
MIMi613203. gene.
neXtProtiNX_Q9BVC3.
PharmGKBiPA162384079.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG250437.
GeneTreeiENSGT00390000017400.
HOGENOMiHOG000008115.
HOVERGENiHBG105358.
InParanoidiQ9BVC3.
KOiK11271.
OMAiGMTTRLD.
OrthoDBiEOG7M6D7D.
PhylomeDBiQ9BVC3.
TreeFamiTF106104.

Miscellaneous databases

ChiTaRSiDSCC1. human.
GeneWikiiDCC1.
GenomeRNAii79075.
NextBioi67873.
PROiQ9BVC3.
SOURCEiSearch...

Gene expression databases

BgeeiQ9BVC3.
CleanExiHS_DSCC1.
GenevisibleiQ9BVC3. HS.

Family and domain databases

InterProiIPR019128. Sister_chromatid_cohesion_Dcc1.
[Graphical view]
PfamiPF09724. DUF2036. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT ARG-376.
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT ARG-376.
    Tissue: Brain and Placenta.
  4. "Cloning and characterization of hCTF18, hCTF8, and hDCC1. Human homologs of a Saccharomyces cerevisiae complex involved in sister chromatid cohesion establishment."
    Merkle C.J., Karnitz L.M., Henry-Sanchez J.T., Chen J.
    J. Biol. Chem. 278:30051-30056(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INTERACTION WITH CTF8 AND CTF18.
  5. "Cohesin acetylation speeds the replication fork."
    Terret M.E., Sherwood R., Rahman S., Qin J., Jallepalli P.V.
    Nature 462:231-234(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION IN DNA REPLICATION AND SISTER CHROMATID COHESION.
  6. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiDCC1_HUMAN
AccessioniPrimary (citable) accession number: Q9BVC3
Secondary accession number(s): Q969N5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: February 5, 2008
Last modified: July 22, 2015
This is version 99 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 8
    Human chromosome 8: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.