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Q9BVC3 (DCC1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 89. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Sister chromatid cohesion protein DCC1
Alternative name(s):
Defective in sister chromatid cohesion protein 1 homolog
Gene names
Name:DSCC1
Synonyms:DCC1
ORF Names:UNQ9337/PRO34008
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length393 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Loads PCNA onto primed templates regulating velocity, spacing and restart activity of replication forks. May couple DNA replication to sister chromatid cohesion through regulation of the acetylation of the cohesin subunit SMC3. Ref.4 Ref.5

Subunit structure

Component of the CTF18-RFC complex which consists of CTF8, CTF18, DSCC1 and the RFC complex. Interacts with CTF8 and CTF18. Ref.4

Subcellular location

Nucleus By similarity.

Sequence similarities

Belongs to the DCC1 family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 393393Sister chromatid cohesion protein DCC1
PRO_0000318064

Natural variations

Natural variant3761H → R. Ref.1 Ref.3
Corresponds to variant rs1055130 [ dbSNP | Ensembl ].
VAR_038682

Sequences

Sequence LengthMass (Da)Tools
Q9BVC3 [UniParc].

Last modified February 5, 2008. Version 2.
Checksum: AAF6C66B7151FA65

FASTA39344,825
        10         20         30         40         50         60 
MKRTRDEVDA TLQIAKLNAA ELLPAVHCLG FGPGASGAAA GDFCLLELEP TLCQQLEDGH 

        70         80         90        100        110        120 
SLVIRGDKDE QAVLCSKDKT YDLKIADTSN MLLFIPGCKT PDQLKKEDSH CNIIHTEIFG 

       130        140        150        160        170        180 
FSNNYWELRR RRPKLKKLKK LLMENPYEGP DSQKEKDSNS SKYTTEDLLD QIQASEEEIM 

       190        200        210        220        230        240 
TQLQVLNACK IGGYWRILEF DYEMKLLNHV TQLVDSESWS FGKVPLNTCL QELGPLEPEE 

       250        260        270        280        290        300 
MIEHCLKCYG KKYVDEGEVY FELDADKICR AAARMLLQNA VKFNLAEFQE VWQQSVPEGM 

       310        320        330        340        350        360 
VTSLDQLKGL ALVDRHSRPE IIFLLKVDDL PEDNQERFNS LFSLREKWTE EDIAPYIQDL 

       370        380        390 
CGEKQTIGAL LTKYSHSSMQ NGVKVYNSRR PIS 

« Hide

References

« Hide 'large scale' references
[1]"The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment."
Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J., Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P., Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E. expand/collapse author list , Heldens S., Huang A., Kim H.S., Klimowski L., Jin Y., Johnson S., Lee J., Lewis L., Liao D., Mark M.R., Robbie E., Sanchez C., Schoenfeld J., Seshagiri S., Simmons L., Singh J., Smith V., Stinson J., Vagts A., Vandlen R.L., Watanabe C., Wieand D., Woods K., Xie M.-H., Yansura D.G., Yi S., Yu G., Yuan J., Zhang M., Zhang Z., Goddard A.D., Wood W.I., Godowski P.J., Gray A.M.
Genome Res. 13:2265-2270(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT ARG-376.
[2]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT ARG-376.
Tissue: Brain and Placenta.
[4]"Cloning and characterization of hCTF18, hCTF8, and hDCC1. Human homologs of a Saccharomyces cerevisiae complex involved in sister chromatid cohesion establishment."
Merkle C.J., Karnitz L.M., Henry-Sanchez J.T., Chen J.
J. Biol. Chem. 278:30051-30056(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION, INTERACTION WITH CTF8 AND CTF18.
[5]"Cohesin acetylation speeds the replication fork."
Terret M.E., Sherwood R., Rahman S., Qin J., Jallepalli P.V.
Nature 462:231-234(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION IN DNA REPLICATION AND SISTER CHROMATID COHESION.
[6]"Initial characterization of the human central proteome."
Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J.
BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AY358866 mRNA. Translation: AAQ89225.1.
AK054585 mRNA. Translation: BAB70767.1.
BC001316 mRNA. Translation: AAH01316.1.
BC001531 mRNA. Translation: AAH01531.1.
CCDSCCDS6330.1.
RefSeqNP_076999.2. NM_024094.2.
UniGeneHs.315167.

3D structure databases

ProteinModelPortalQ9BVC3.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid122526. 5 interactions.
STRING9606.ENSP00000322180.

PTM databases

PhosphoSiteQ9BVC3.

Polymorphism databases

DMDM167012058.

Proteomic databases

MaxQBQ9BVC3.
PaxDbQ9BVC3.
PRIDEQ9BVC3.

Protocols and materials databases

DNASU79075.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000313655; ENSP00000322180; ENSG00000136982.
GeneID79075.
KEGGhsa:79075.
UCSCuc003yov.3. human.

Organism-specific databases

CTD79075.
GeneCardsGC08M120846.
HGNCHGNC:24453. DSCC1.
HPAHPA023780.
HPA024401.
MIM613203. gene.
neXtProtNX_Q9BVC3.
PharmGKBPA162384079.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG250437.
HOGENOMHOG000008115.
HOVERGENHBG105358.
InParanoidQ9BVC3.
KOK11271.
OMAGMTTRLD.
OrthoDBEOG7M6D7D.
PhylomeDBQ9BVC3.
TreeFamTF106104.

Gene expression databases

BgeeQ9BVC3.
CleanExHS_DSCC1.
GenevestigatorQ9BVC3.

Family and domain databases

InterProIPR019128. Sister_chromatid_cohesion_Dcc1.
[Graphical view]
PfamPF09724. DUF2036. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GeneWikiDCC1.
GenomeRNAi79075.
NextBio67873.
PROQ9BVC3.
SOURCESearch...

Entry information

Entry nameDCC1_HUMAN
AccessionPrimary (citable) accession number: Q9BVC3
Secondary accession number(s): Q969N5
Entry history
Integrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: February 5, 2008
Last modified: July 9, 2014
This is version 89 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 8

Human chromosome 8: entries, gene names and cross-references to MIM