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Q9BVC3

- DCC1_HUMAN

UniProt

Q9BVC3 - DCC1_HUMAN

Protein

Sister chromatid cohesion protein DCC1

Gene

DSCC1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 90 (01 Oct 2014)
      Sequence version 2 (05 Feb 2008)
      Previous versions | rss
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    Functioni

    Loads PCNA onto primed templates regulating velocity, spacing and restart activity of replication forks. May couple DNA replication to sister chromatid cohesion through regulation of the acetylation of the cohesin subunit SMC3.2 Publications

    GO - Molecular functioni

    1. DNA binding Source: UniProtKB-KW
    2. protein binding Source: UniProtKB

    GO - Biological processi

    1. DNA replication Source: UniProtKB-KW
    2. maintenance of mitotic sister chromatid cohesion Source: UniProtKB
    3. post-translational protein acetylation Source: UniProtKB
    4. regulation of DNA replication Source: UniProtKB

    Keywords - Biological processi

    Cell cycle, DNA replication

    Keywords - Ligandi

    DNA-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Sister chromatid cohesion protein DCC1
    Alternative name(s):
    Defective in sister chromatid cohesion protein 1 homolog
    Gene namesi
    Name:DSCC1
    Synonyms:DCC1
    ORF Names:UNQ9337/PRO34008
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 8

    Organism-specific databases

    HGNCiHGNC:24453. DSCC1.

    Subcellular locationi

    Nucleus By similarity

    GO - Cellular componenti

    1. chromatin Source: UniProtKB
    2. chromosome, centromeric region Source: UniProtKB
    3. nucleoplasm Source: UniProtKB

    Keywords - Cellular componenti

    Nucleus

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA162384079.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 393393Sister chromatid cohesion protein DCC1PRO_0000318064Add
    BLAST

    Proteomic databases

    MaxQBiQ9BVC3.
    PaxDbiQ9BVC3.
    PRIDEiQ9BVC3.

    PTM databases

    PhosphoSiteiQ9BVC3.

    Expressioni

    Gene expression databases

    BgeeiQ9BVC3.
    CleanExiHS_DSCC1.
    GenevestigatoriQ9BVC3.

    Organism-specific databases

    HPAiHPA023780.
    HPA024401.

    Interactioni

    Subunit structurei

    Component of the CTF18-RFC complex which consists of CTF8, CTF18, DSCC1 and the RFC complex. Interacts with CTF8 and CTF18.1 Publication

    Protein-protein interaction databases

    BioGridi122526. 5 interactions.
    STRINGi9606.ENSP00000322180.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9BVC3.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the DCC1 family.Curated

    Phylogenomic databases

    eggNOGiNOG250437.
    HOGENOMiHOG000008115.
    HOVERGENiHBG105358.
    InParanoidiQ9BVC3.
    KOiK11271.
    OMAiGMTTRLD.
    OrthoDBiEOG7M6D7D.
    PhylomeDBiQ9BVC3.
    TreeFamiTF106104.

    Family and domain databases

    InterProiIPR019128. Sister_chromatid_cohesion_Dcc1.
    [Graphical view]
    PfamiPF09724. DUF2036. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9BVC3-1 [UniParc]FASTAAdd to Basket

    « Hide

    MKRTRDEVDA TLQIAKLNAA ELLPAVHCLG FGPGASGAAA GDFCLLELEP    50
    TLCQQLEDGH SLVIRGDKDE QAVLCSKDKT YDLKIADTSN MLLFIPGCKT 100
    PDQLKKEDSH CNIIHTEIFG FSNNYWELRR RRPKLKKLKK LLMENPYEGP 150
    DSQKEKDSNS SKYTTEDLLD QIQASEEEIM TQLQVLNACK IGGYWRILEF 200
    DYEMKLLNHV TQLVDSESWS FGKVPLNTCL QELGPLEPEE MIEHCLKCYG 250
    KKYVDEGEVY FELDADKICR AAARMLLQNA VKFNLAEFQE VWQQSVPEGM 300
    VTSLDQLKGL ALVDRHSRPE IIFLLKVDDL PEDNQERFNS LFSLREKWTE 350
    EDIAPYIQDL CGEKQTIGAL LTKYSHSSMQ NGVKVYNSRR PIS 393
    Length:393
    Mass (Da):44,825
    Last modified:February 5, 2008 - v2
    Checksum:iAAF6C66B7151FA65
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti376 – 3761H → R.2 Publications
    Corresponds to variant rs1055130 [ dbSNP | Ensembl ].
    VAR_038682

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY358866 mRNA. Translation: AAQ89225.1.
    AK054585 mRNA. Translation: BAB70767.1.
    BC001316 mRNA. Translation: AAH01316.1.
    BC001531 mRNA. Translation: AAH01531.1.
    CCDSiCCDS6330.1.
    RefSeqiNP_076999.2. NM_024094.2.
    UniGeneiHs.315167.

    Genome annotation databases

    EnsembliENST00000313655; ENSP00000322180; ENSG00000136982.
    GeneIDi79075.
    KEGGihsa:79075.
    UCSCiuc003yov.3. human.

    Polymorphism databases

    DMDMi167012058.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY358866 mRNA. Translation: AAQ89225.1 .
    AK054585 mRNA. Translation: BAB70767.1 .
    BC001316 mRNA. Translation: AAH01316.1 .
    BC001531 mRNA. Translation: AAH01531.1 .
    CCDSi CCDS6330.1.
    RefSeqi NP_076999.2. NM_024094.2.
    UniGenei Hs.315167.

    3D structure databases

    ProteinModelPortali Q9BVC3.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 122526. 5 interactions.
    STRINGi 9606.ENSP00000322180.

    PTM databases

    PhosphoSitei Q9BVC3.

    Polymorphism databases

    DMDMi 167012058.

    Proteomic databases

    MaxQBi Q9BVC3.
    PaxDbi Q9BVC3.
    PRIDEi Q9BVC3.

    Protocols and materials databases

    DNASUi 79075.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000313655 ; ENSP00000322180 ; ENSG00000136982 .
    GeneIDi 79075.
    KEGGi hsa:79075.
    UCSCi uc003yov.3. human.

    Organism-specific databases

    CTDi 79075.
    GeneCardsi GC08M120846.
    HGNCi HGNC:24453. DSCC1.
    HPAi HPA023780.
    HPA024401.
    MIMi 613203. gene.
    neXtProti NX_Q9BVC3.
    PharmGKBi PA162384079.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG250437.
    HOGENOMi HOG000008115.
    HOVERGENi HBG105358.
    InParanoidi Q9BVC3.
    KOi K11271.
    OMAi GMTTRLD.
    OrthoDBi EOG7M6D7D.
    PhylomeDBi Q9BVC3.
    TreeFami TF106104.

    Miscellaneous databases

    GeneWikii DCC1.
    GenomeRNAii 79075.
    NextBioi 67873.
    PROi Q9BVC3.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q9BVC3.
    CleanExi HS_DSCC1.
    Genevestigatori Q9BVC3.

    Family and domain databases

    InterProi IPR019128. Sister_chromatid_cohesion_Dcc1.
    [Graphical view ]
    Pfami PF09724. DUF2036. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT ARG-376.
    2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT ARG-376.
      Tissue: Brain and Placenta.
    4. "Cloning and characterization of hCTF18, hCTF8, and hDCC1. Human homologs of a Saccharomyces cerevisiae complex involved in sister chromatid cohesion establishment."
      Merkle C.J., Karnitz L.M., Henry-Sanchez J.T., Chen J.
      J. Biol. Chem. 278:30051-30056(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, INTERACTION WITH CTF8 AND CTF18.
    5. "Cohesin acetylation speeds the replication fork."
      Terret M.E., Sherwood R., Rahman S., Qin J., Jallepalli P.V.
      Nature 462:231-234(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION IN DNA REPLICATION AND SISTER CHROMATID COHESION.
    6. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiDCC1_HUMAN
    AccessioniPrimary (citable) accession number: Q9BVC3
    Secondary accession number(s): Q969N5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 5, 2008
    Last sequence update: February 5, 2008
    Last modified: October 1, 2014
    This is version 90 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 8
      Human chromosome 8: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3