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Q9BVA0

- KTNB1_HUMAN

UniProt

Q9BVA0 - KTNB1_HUMAN

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Protein
Katanin p80 WD40 repeat-containing subunit B1
Gene
KATNB1
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Participates in a complex which severs microtubules in an ATP-dependent manner. May act to target the enzymatic subunit of this complex to sites of action such as the centrosome. Microtubule severing may promote rapid reorganization of cellular microtubule arrays and the release of microtubules from the centrosome following nucleation. Microtubule release from the mitotic spindle poles may allow depolymerization of the microtubule end proximal to the spindle pole, leading to poleward microtubule flux and poleward motion of chromosome. Microtubule release within the cell body of neurons may be required for their transport into neuronal processes by microtubule-dependent motor proteins. This transport is required for axonal growth By similarity.1 Publication

GO - Molecular functioni

  1. microtubule binding Source: UniProtKB
  2. protein heterodimerization activity Source: UniProtKB
Complete GO annotation...

GO - Biological processi

  1. ATP catabolic process Source: GOC
  2. microtubule severing Source: UniProtKB-HAMAP
  3. mitotic chromosome movement towards spindle pole Source: UniProtKB-HAMAP
  4. negative regulation of microtubule depolymerization Source: UniProtKB
  5. positive regulation of cell death Source: Ensembl
  6. positive regulation of microtubule depolymerization Source: UniProtKB
  7. positive regulation of neuron projection development Source: Ensembl
  8. protein targeting Source: UniProtKB
Complete GO annotation...

Keywords - Biological processi

Cell cycle, Cell division, Mitosis

Enzyme and pathway databases

SignaLinkiQ9BVA0.

Names & Taxonomyi

Protein namesi
Recommended name:
Katanin p80 WD40 repeat-containing subunit B1
Short name:
Katanin p80 subunit B1
Alternative name(s):
p80 katanin
Gene namesi
Name:KATNB1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 16

Organism-specific databases

HGNCiHGNC:6217. KATNB1.

Subcellular locationi

Cytoplasm. Cytoplasmcytoskeletonmicrotubule organizing centercentrosome. Cytoplasmcytoskeletonspindle pole. Cytoplasmcytoskeleton
Note: Predominantly cytoplasmic. Localized to the interphase centrosome and mitotic spindle poles.3 Publications

GO - Cellular componenti

  1. axon Source: Ensembl
  2. centrosome Source: UniProtKB-HAMAP
  3. cytoplasm Source: UniProtKB
  4. growth cone Source: Ensembl
  5. katanin complex Source: UniProtKB
  6. microtubule Source: UniProtKB-KW
  7. midbody Source: Ensembl
  8. neuronal cell body Source: Ensembl
  9. nucleus Source: UniProt
  10. spindle pole Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Microtubule

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA30018.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 655655Katanin p80 WD40 repeat-containing subunit B1UniRule annotation
PRO_0000051049Add
BLAST

Proteomic databases

MaxQBiQ9BVA0.
PaxDbiQ9BVA0.
PRIDEiQ9BVA0.

PTM databases

PhosphoSiteiQ9BVA0.

Expressioni

Gene expression databases

ArrayExpressiQ9BVA0.
BgeeiQ9BVA0.
CleanExiHS_KATNB1.
GenevestigatoriQ9BVA0.

Organism-specific databases

HPAiHPA041165.
HPA041839.

Interactioni

Subunit structurei

Interacts with PAFAH1B1 By similarity. Interacts with KATNA1. This interaction enhances the microtubule binding and severing activity of KATNA1 and also targets this activity to the centrosome. Interacts with dynein, microtubules and NDEL1.2 Publications

Protein-protein interaction databases

BioGridi115588. 15 interactions.
MINTiMINT-4989412.
STRINGi9606.ENSP00000268509.

Structurei

3D structure databases

ProteinModelPortaliQ9BVA0.
SMRiQ9BVA0. Positions 8-324.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati18 – 5841WD 1UniRule annotation
Add
BLAST
Repeati61 – 10040WD 2UniRule annotation
Add
BLAST
Repeati103 – 14240WD 3UniRule annotation
Add
BLAST
Repeati145 – 18440WD 4UniRule annotation
Add
BLAST
Repeati187 – 22640WD 5UniRule annotation
Add
BLAST
Repeati229 – 26941WD 6UniRule annotation
Add
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1 – 300300Interaction with centrosomesUniRule annotation
Add
BLAST
Regioni1 – 284284Interaction with dynein By similarity
Add
BLAST
Regioni285 – 434150Interaction with PAFAH1B1 By similarity
Add
BLAST
Regioni433 – 655223Interaction with KATNA1 and NDEL1 By similarity
Add
BLAST

Sequence similaritiesi

Belongs to the WD repeat KATNB1 family.
Contains 6 WD repeats.

Keywords - Domaini

Repeat, WD repeat

Phylogenomic databases

eggNOGiCOG2319.
HOGENOMiHOG000008039.
HOVERGENiHBG052294.
InParanoidiQ9BVA0.
OMAiACSKPQR.
PhylomeDBiQ9BVA0.
TreeFamiTF332359.

Family and domain databases

Gene3Di2.130.10.10. 1 hit.
HAMAPiMF_03022. Katanin_p80_B1.
InterProiIPR020472. G-protein_beta_WD-40_rep.
IPR026962. Katanin_bsu1.
IPR028021. Katanin_C-terminal.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR019775. WD40_repeat_CS.
IPR017986. WD40_repeat_dom.
[Graphical view]
PfamiPF13925. Katanin_con80. 1 hit.
PF00400. WD40. 6 hits.
[Graphical view]
PRINTSiPR00320. GPROTEINBRPT.
SMARTiSM00320. WD40. 6 hits.
[Graphical view]
SUPFAMiSSF50978. SSF50978. 1 hit.
PROSITEiPS00678. WD_REPEATS_1. 3 hits.
PS50082. WD_REPEATS_2. 5 hits.
PS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9BVA0-1 [UniParc]FASTAAdd to Basket

« Hide

MATPVVTKTA WKLQEIVAHA SNVSSLVLGK ASGRLLATGG DDCRVNLWSI    50
NKPNCIMSLT GHTSPVESVR LNTPEELIVA GSQSGSIRVW DLEAAKILRT 100
LMGHKANICS LDFHPYGEFV ASGSQDTNIK LWDIRRKGCV FRYRGHSQAV 150
RCLRFSPDGK WLASAADDHT VKLWDLTAGK MMSEFPGHTG PVNVVEFHPN 200
EYLLASGSSD RTIRFWDLEK FQVVSCIEGE PGPVRSVLFN PDGCCLYSGC 250
QDSLRVYGWE PERCFDVVLV NWGKVADLAI CNDQLIGVAF SQSNVSSYVV 300
DLTRVTRTGT VARDPVQDHR PLAQPLPNPS APLRRIYERP STTCSKPQRV 350
KQNSESERRS PSSEDDRDER ESRAEIQNAE DYNEIFQPKN SISRTPPRRS 400
EPFPAPPEDD AATAKEAAKP SPAMDVQFPV PNLEVLPRPP VVASTPAPKA 450
EPAIIPATRN EPIGLKASDF LPAVKIPQQA ELVDEDAMSQ IRKGHDTMCV 500
VLTSRHKNLD TVRAVWTMGD IKTSVDSAVA INDLSVVVDL LNIVNQKASL 550
WKLDLCTTVL PQIEKLLQSK YESYVQTGCT SLKLILQRFL PLITDMLAAP 600
PSVGVDISRE ERLHKCRLCY KQLKSISGLV KSKSGLSGRH GSTFRELHLL 650
MASLD 655
Length:655
Mass (Da):72,334
Last modified:June 1, 2001 - v1
Checksum:i411903E306B6EC16
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti181 – 1811M → V.
Corresponds to variant rs60158050 [ dbSNP | Ensembl ].
VAR_062099

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti104 – 1041H → L in AAC09328. 1 Publication
Sequence conflicti211 – 2111R → G in AAC09328. 1 Publication
Sequence conflicti226 – 2261C → R in AAC09328. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF052432 mRNA. Translation: AAC09328.1.
BT007022 mRNA. Translation: AAP35668.1.
CR456762 mRNA. Translation: CAG33043.1.
AC092118 Genomic DNA. No translation available.
CH471092 Genomic DNA. Translation: EAW82951.1.
BC001353 mRNA. Translation: AAH01353.1.
CCDSiCCDS10788.1.
RefSeqiNP_005877.2. NM_005886.2.
UniGeneiHs.275675.
Hs.732486.

Genome annotation databases

EnsembliENST00000379661; ENSP00000368982; ENSG00000140854.
ENST00000594746; ENSP00000470131; ENSG00000268329.
GeneIDi10300.
KEGGihsa:10300.
UCSCiuc002eml.1. human.

Polymorphism databases

DMDMi60390213.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF052432 mRNA. Translation: AAC09328.1 .
BT007022 mRNA. Translation: AAP35668.1 .
CR456762 mRNA. Translation: CAG33043.1 .
AC092118 Genomic DNA. No translation available.
CH471092 Genomic DNA. Translation: EAW82951.1 .
BC001353 mRNA. Translation: AAH01353.1 .
CCDSi CCDS10788.1.
RefSeqi NP_005877.2. NM_005886.2.
UniGenei Hs.275675.
Hs.732486.

3D structure databases

ProteinModelPortali Q9BVA0.
SMRi Q9BVA0. Positions 8-324.
ModBasei Search...

Protein-protein interaction databases

BioGridi 115588. 15 interactions.
MINTi MINT-4989412.
STRINGi 9606.ENSP00000268509.

PTM databases

PhosphoSitei Q9BVA0.

Polymorphism databases

DMDMi 60390213.

Proteomic databases

MaxQBi Q9BVA0.
PaxDbi Q9BVA0.
PRIDEi Q9BVA0.

Protocols and materials databases

DNASUi 10300.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000379661 ; ENSP00000368982 ; ENSG00000140854 .
ENST00000594746 ; ENSP00000470131 ; ENSG00000268329 .
GeneIDi 10300.
KEGGi hsa:10300.
UCSCi uc002eml.1. human.

Organism-specific databases

CTDi 10300.
GeneCardsi GC16P057770.
HGNCi HGNC:6217. KATNB1.
HPAi HPA041165.
HPA041839.
MIMi 602703. gene.
neXtProti NX_Q9BVA0.
PharmGKBi PA30018.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG2319.
HOGENOMi HOG000008039.
HOVERGENi HBG052294.
InParanoidi Q9BVA0.
OMAi ACSKPQR.
PhylomeDBi Q9BVA0.
TreeFami TF332359.

Enzyme and pathway databases

SignaLinki Q9BVA0.

Miscellaneous databases

GeneWikii KATNB1.
GenomeRNAii 10300.
NextBioi 39044.
PROi Q9BVA0.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q9BVA0.
Bgeei Q9BVA0.
CleanExi HS_KATNB1.
Genevestigatori Q9BVA0.

Family and domain databases

Gene3Di 2.130.10.10. 1 hit.
HAMAPi MF_03022. Katanin_p80_B1.
InterProi IPR020472. G-protein_beta_WD-40_rep.
IPR026962. Katanin_bsu1.
IPR028021. Katanin_C-terminal.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR019775. WD40_repeat_CS.
IPR017986. WD40_repeat_dom.
[Graphical view ]
Pfami PF13925. Katanin_con80. 1 hit.
PF00400. WD40. 6 hits.
[Graphical view ]
PRINTSi PR00320. GPROTEINBRPT.
SMARTi SM00320. WD40. 6 hits.
[Graphical view ]
SUPFAMi SSF50978. SSF50978. 1 hit.
PROSITEi PS00678. WD_REPEATS_1. 3 hits.
PS50082. WD_REPEATS_2. 5 hits.
PS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Katanin, a microtubule-severing protein, is a novel AAA ATPase that targets to the centrosome using a WD40-containing subunit."
    Hartman J.J., Mahr J., McNally K., Okawa K., Iwamatsu A., Thomas S., Cheesman S., Heuser J., Vale R.D., McNally F.J.
    Cell 93:277-287(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], SUBCELLULAR LOCATION.
  2. "Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
    Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A.
    Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  3. "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
    Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.
    Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  4. "The sequence and analysis of duplication-rich human chromosome 16."
    Martin J., Han C., Gordon L.A., Terry A., Prabhakar S., She X., Xie G., Hellsten U., Chan Y.M., Altherr M., Couronne O., Aerts A., Bajorek E., Black S., Blumer H., Branscomb E., Brown N.C., Bruno W.J.
    , Buckingham J.M., Callen D.F., Campbell C.S., Campbell M.L., Campbell E.W., Caoile C., Challacombe J.F., Chasteen L.A., Chertkov O., Chi H.C., Christensen M., Clark L.M., Cohn J.D., Denys M., Detter J.C., Dickson M., Dimitrijevic-Bussod M., Escobar J., Fawcett J.J., Flowers D., Fotopulos D., Glavina T., Gomez M., Gonzales E., Goodstein D., Goodwin L.A., Grady D.L., Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Hildebrand C.E., Huang W., Israni S., Jett J., Jewett P.B., Kadner K., Kimball H., Kobayashi A., Krawczyk M.-C., Leyba T., Longmire J.L., Lopez F., Lou Y., Lowry S., Ludeman T., Manohar C.F., Mark G.A., McMurray K.L., Meincke L.J., Morgan J., Moyzis R.K., Mundt M.O., Munk A.C., Nandkeshwar R.D., Pitluck S., Pollard M., Predki P., Parson-Quintana B., Ramirez L., Rash S., Retterer J., Ricke D.O., Robinson D.L., Rodriguez A., Salamov A., Saunders E.H., Scott D., Shough T., Stallings R.L., Stalvey M., Sutherland R.D., Tapia R., Tesmer J.G., Thayer N., Thompson L.S., Tice H., Torney D.C., Tran-Gyamfi M., Tsai M., Ulanovsky L.E., Ustaszewska A., Vo N., White P.S., Williams A.L., Wills P.L., Wu J.-R., Wu K., Yang J., DeJong P., Bruce D., Doggett N.A., Deaven L., Schmutz J., Grimwood J., Richardson P., Rokhsar D.S., Eichler E.E., Gilna P., Lucas S.M., Myers R.M., Rubin E.M., Pennacchio L.A.
    Nature 432:988-994(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Muscle.
  7. "Katanin is responsible for the M-phase microtubule-severing activity in Xenopus eggs."
    McNally F.J., Thomas S.
    Mol. Biol. Cell 9:1847-1861(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION.
  8. "Two domains of p80 katanin regulate microtubule severing and spindle pole targeting by p60 katanin."
    McNally K.P., Bazirgan O.A., McNally F.J.
    J. Cell Sci. 113:1623-1633(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INTERACTION WITH KATNA1.
  9. "Recruitment of katanin p60 by phosphorylated NDEL1, an LIS1 interacting protein, is essential for mitotic cell division and neuronal migration."
    Toyo-Oka K., Sasaki S., Yano Y., Mori D., Kobayashi T., Toyoshima Y.Y., Tokuoka S.M., Ishii S., Shimizu T., Muramatsu M., Hiraiwa N., Yoshiki A., Wynshaw-Boris A., Hirotsune S.
    Hum. Mol. Genet. 14:3113-3128(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH NDEL1, SUBCELLULAR LOCATION.
  10. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiKTNB1_HUMAN
AccessioniPrimary (citable) accession number: Q9BVA0
Secondary accession number(s): A6NCG6, O60620
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 1, 2005
Last sequence update: June 1, 2001
Last modified: July 9, 2014
This is version 116 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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