Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Q9BVA0

- KTNB1_HUMAN

UniProt

Q9BVA0 - KTNB1_HUMAN

Protein

Katanin p80 WD40 repeat-containing subunit B1

Gene

KATNB1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 117 (01 Oct 2014)
      Sequence version 1 (01 Jun 2001)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Participates in a complex which severs microtubules in an ATP-dependent manner. May act to target the enzymatic subunit of this complex to sites of action such as the centrosome. Microtubule severing may promote rapid reorganization of cellular microtubule arrays and the release of microtubules from the centrosome following nucleation. Microtubule release from the mitotic spindle poles may allow depolymerization of the microtubule end proximal to the spindle pole, leading to poleward microtubule flux and poleward motion of chromosome. Microtubule release within the cell body of neurons may be required for their transport into neuronal processes by microtubule-dependent motor proteins. This transport is required for axonal growth.UniRule annotation

    GO - Molecular functioni

    1. microtubule binding Source: UniProtKB
    2. protein heterodimerization activity Source: UniProtKB

    GO - Biological processi

    1. ATP catabolic process Source: GOC
    2. microtubule severing Source: UniProtKB-HAMAP
    3. mitotic chromosome movement towards spindle pole Source: UniProtKB-HAMAP
    4. negative regulation of microtubule depolymerization Source: UniProtKB
    5. positive regulation of cell death Source: Ensembl
    6. positive regulation of microtubule depolymerization Source: UniProtKB
    7. positive regulation of neuron projection development Source: Ensembl
    8. protein targeting Source: UniProtKB

    Keywords - Biological processi

    Cell cycle, Cell division, Mitosis

    Enzyme and pathway databases

    SignaLinkiQ9BVA0.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Katanin p80 WD40 repeat-containing subunit B1UniRule annotation
    Short name:
    Katanin p80 subunit B1UniRule annotation
    Alternative name(s):
    p80 kataninUniRule annotation
    Gene namesi
    Name:KATNB1UniRule annotation
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 16

    Organism-specific databases

    HGNCiHGNC:6217. KATNB1.

    Subcellular locationi

    Cytoplasm. Cytoplasmcytoskeletonmicrotubule organizing centercentrosome. Cytoplasmcytoskeletonspindle pole. Cytoplasmcytoskeleton
    Note: Predominantly cytoplasmic. Localized to the interphase centrosome and mitotic spindle poles.

    GO - Cellular componenti

    1. axon Source: Ensembl
    2. centrosome Source: UniProtKB-HAMAP
    3. cytoplasm Source: UniProtKB
    4. growth cone Source: Ensembl
    5. katanin complex Source: UniProtKB
    6. membrane Source: UniProtKB
    7. microtubule Source: UniProtKB-KW
    8. midbody Source: Ensembl
    9. neuronal cell body Source: Ensembl
    10. nucleus Source: UniProt
    11. spindle pole Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm, Cytoskeleton, Microtubule

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA30018.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 655655Katanin p80 WD40 repeat-containing subunit B1PRO_0000051049Add
    BLAST

    Proteomic databases

    MaxQBiQ9BVA0.
    PaxDbiQ9BVA0.
    PRIDEiQ9BVA0.

    PTM databases

    PhosphoSiteiQ9BVA0.

    Expressioni

    Gene expression databases

    ArrayExpressiQ9BVA0.
    BgeeiQ9BVA0.
    CleanExiHS_KATNB1.
    GenevestigatoriQ9BVA0.

    Organism-specific databases

    HPAiHPA041165.
    HPA041839.

    Interactioni

    Subunit structurei

    Interacts with PAFAH1B1 By similarity. Interacts with KATNA1. This interaction enhances the microtubule binding and severing activity of KATNA1 and also targets this activity to the centrosome. Interacts with dynein, microtubules and NDEL1.By similarity2 Publications

    Protein-protein interaction databases

    BioGridi115588. 15 interactions.
    MINTiMINT-4989412.
    STRINGi9606.ENSP00000268509.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9BVA0.
    SMRiQ9BVA0. Positions 8-324.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Repeati18 – 5841WD 1Add
    BLAST
    Repeati61 – 10040WD 2Add
    BLAST
    Repeati103 – 14240WD 3Add
    BLAST
    Repeati145 – 18440WD 4Add
    BLAST
    Repeati187 – 22640WD 5Add
    BLAST
    Repeati229 – 26941WD 6Add
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni1 – 300300Interaction with centrosomesAdd
    BLAST
    Regioni1 – 284284Interaction with dyneinBy similarityAdd
    BLAST
    Regioni285 – 434150Interaction with PAFAH1B1By similarityAdd
    BLAST
    Regioni433 – 655223Interaction with KATNA1 and NDEL1By similarityAdd
    BLAST

    Sequence similaritiesi

    Belongs to the WD repeat KATNB1 family.UniRule annotation
    Contains 6 WD repeats.UniRule annotation

    Keywords - Domaini

    Repeat, WD repeat

    Phylogenomic databases

    eggNOGiCOG2319.
    HOGENOMiHOG000008039.
    HOVERGENiHBG052294.
    InParanoidiQ9BVA0.
    OMAiACSKPQR.
    PhylomeDBiQ9BVA0.
    TreeFamiTF332359.

    Family and domain databases

    Gene3Di2.130.10.10. 1 hit.
    HAMAPiMF_03022. Katanin_p80_B1.
    InterProiIPR020472. G-protein_beta_WD-40_rep.
    IPR026962. Katanin_bsu1.
    IPR028021. Katanin_C-terminal.
    IPR015943. WD40/YVTN_repeat-like_dom.
    IPR001680. WD40_repeat.
    IPR019775. WD40_repeat_CS.
    IPR017986. WD40_repeat_dom.
    [Graphical view]
    PfamiPF13925. Katanin_con80. 1 hit.
    PF00400. WD40. 6 hits.
    [Graphical view]
    PRINTSiPR00320. GPROTEINBRPT.
    SMARTiSM00320. WD40. 6 hits.
    [Graphical view]
    SUPFAMiSSF50978. SSF50978. 1 hit.
    PROSITEiPS00678. WD_REPEATS_1. 3 hits.
    PS50082. WD_REPEATS_2. 5 hits.
    PS50294. WD_REPEATS_REGION. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9BVA0-1 [UniParc]FASTAAdd to Basket

    « Hide

    MATPVVTKTA WKLQEIVAHA SNVSSLVLGK ASGRLLATGG DDCRVNLWSI    50
    NKPNCIMSLT GHTSPVESVR LNTPEELIVA GSQSGSIRVW DLEAAKILRT 100
    LMGHKANICS LDFHPYGEFV ASGSQDTNIK LWDIRRKGCV FRYRGHSQAV 150
    RCLRFSPDGK WLASAADDHT VKLWDLTAGK MMSEFPGHTG PVNVVEFHPN 200
    EYLLASGSSD RTIRFWDLEK FQVVSCIEGE PGPVRSVLFN PDGCCLYSGC 250
    QDSLRVYGWE PERCFDVVLV NWGKVADLAI CNDQLIGVAF SQSNVSSYVV 300
    DLTRVTRTGT VARDPVQDHR PLAQPLPNPS APLRRIYERP STTCSKPQRV 350
    KQNSESERRS PSSEDDRDER ESRAEIQNAE DYNEIFQPKN SISRTPPRRS 400
    EPFPAPPEDD AATAKEAAKP SPAMDVQFPV PNLEVLPRPP VVASTPAPKA 450
    EPAIIPATRN EPIGLKASDF LPAVKIPQQA ELVDEDAMSQ IRKGHDTMCV 500
    VLTSRHKNLD TVRAVWTMGD IKTSVDSAVA INDLSVVVDL LNIVNQKASL 550
    WKLDLCTTVL PQIEKLLQSK YESYVQTGCT SLKLILQRFL PLITDMLAAP 600
    PSVGVDISRE ERLHKCRLCY KQLKSISGLV KSKSGLSGRH GSTFRELHLL 650
    MASLD 655
    Length:655
    Mass (Da):72,334
    Last modified:June 1, 2001 - v1
    Checksum:i411903E306B6EC16
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti104 – 1041H → L in AAC09328. (PubMed:9568719)Curated
    Sequence conflicti211 – 2111R → G in AAC09328. (PubMed:9568719)Curated
    Sequence conflicti226 – 2261C → R in AAC09328. (PubMed:9568719)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti181 – 1811M → V.
    Corresponds to variant rs60158050 [ dbSNP | Ensembl ].
    VAR_062099

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF052432 mRNA. Translation: AAC09328.1.
    BT007022 mRNA. Translation: AAP35668.1.
    CR456762 mRNA. Translation: CAG33043.1.
    AC092118 Genomic DNA. No translation available.
    CH471092 Genomic DNA. Translation: EAW82951.1.
    BC001353 mRNA. Translation: AAH01353.1.
    CCDSiCCDS10788.1.
    RefSeqiNP_005877.2. NM_005886.2.
    UniGeneiHs.275675.
    Hs.732486.

    Genome annotation databases

    EnsembliENST00000379661; ENSP00000368982; ENSG00000140854.
    GeneIDi10300.
    KEGGihsa:10300.
    UCSCiuc002eml.1. human.

    Polymorphism databases

    DMDMi60390213.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF052432 mRNA. Translation: AAC09328.1 .
    BT007022 mRNA. Translation: AAP35668.1 .
    CR456762 mRNA. Translation: CAG33043.1 .
    AC092118 Genomic DNA. No translation available.
    CH471092 Genomic DNA. Translation: EAW82951.1 .
    BC001353 mRNA. Translation: AAH01353.1 .
    CCDSi CCDS10788.1.
    RefSeqi NP_005877.2. NM_005886.2.
    UniGenei Hs.275675.
    Hs.732486.

    3D structure databases

    ProteinModelPortali Q9BVA0.
    SMRi Q9BVA0. Positions 8-324.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 115588. 15 interactions.
    MINTi MINT-4989412.
    STRINGi 9606.ENSP00000268509.

    PTM databases

    PhosphoSitei Q9BVA0.

    Polymorphism databases

    DMDMi 60390213.

    Proteomic databases

    MaxQBi Q9BVA0.
    PaxDbi Q9BVA0.
    PRIDEi Q9BVA0.

    Protocols and materials databases

    DNASUi 10300.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000379661 ; ENSP00000368982 ; ENSG00000140854 .
    GeneIDi 10300.
    KEGGi hsa:10300.
    UCSCi uc002eml.1. human.

    Organism-specific databases

    CTDi 10300.
    GeneCardsi GC16P057770.
    HGNCi HGNC:6217. KATNB1.
    HPAi HPA041165.
    HPA041839.
    MIMi 602703. gene.
    neXtProti NX_Q9BVA0.
    PharmGKBi PA30018.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG2319.
    HOGENOMi HOG000008039.
    HOVERGENi HBG052294.
    InParanoidi Q9BVA0.
    OMAi ACSKPQR.
    PhylomeDBi Q9BVA0.
    TreeFami TF332359.

    Enzyme and pathway databases

    SignaLinki Q9BVA0.

    Miscellaneous databases

    GeneWikii KATNB1.
    GenomeRNAii 10300.
    NextBioi 39044.
    PROi Q9BVA0.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q9BVA0.
    Bgeei Q9BVA0.
    CleanExi HS_KATNB1.
    Genevestigatori Q9BVA0.

    Family and domain databases

    Gene3Di 2.130.10.10. 1 hit.
    HAMAPi MF_03022. Katanin_p80_B1.
    InterProi IPR020472. G-protein_beta_WD-40_rep.
    IPR026962. Katanin_bsu1.
    IPR028021. Katanin_C-terminal.
    IPR015943. WD40/YVTN_repeat-like_dom.
    IPR001680. WD40_repeat.
    IPR019775. WD40_repeat_CS.
    IPR017986. WD40_repeat_dom.
    [Graphical view ]
    Pfami PF13925. Katanin_con80. 1 hit.
    PF00400. WD40. 6 hits.
    [Graphical view ]
    PRINTSi PR00320. GPROTEINBRPT.
    SMARTi SM00320. WD40. 6 hits.
    [Graphical view ]
    SUPFAMi SSF50978. SSF50978. 1 hit.
    PROSITEi PS00678. WD_REPEATS_1. 3 hits.
    PS50082. WD_REPEATS_2. 5 hits.
    PS50294. WD_REPEATS_REGION. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Katanin, a microtubule-severing protein, is a novel AAA ATPase that targets to the centrosome using a WD40-containing subunit."
      Hartman J.J., Mahr J., McNally K., Okawa K., Iwamatsu A., Thomas S., Cheesman S., Heuser J., Vale R.D., McNally F.J.
      Cell 93:277-287(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], SUBCELLULAR LOCATION.
    2. "Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
      Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A.
      Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    3. "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
      Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.
      Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    4. "The sequence and analysis of duplication-rich human chromosome 16."
      Martin J., Han C., Gordon L.A., Terry A., Prabhakar S., She X., Xie G., Hellsten U., Chan Y.M., Altherr M., Couronne O., Aerts A., Bajorek E., Black S., Blumer H., Branscomb E., Brown N.C., Bruno W.J.
      , Buckingham J.M., Callen D.F., Campbell C.S., Campbell M.L., Campbell E.W., Caoile C., Challacombe J.F., Chasteen L.A., Chertkov O., Chi H.C., Christensen M., Clark L.M., Cohn J.D., Denys M., Detter J.C., Dickson M., Dimitrijevic-Bussod M., Escobar J., Fawcett J.J., Flowers D., Fotopulos D., Glavina T., Gomez M., Gonzales E., Goodstein D., Goodwin L.A., Grady D.L., Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Hildebrand C.E., Huang W., Israni S., Jett J., Jewett P.B., Kadner K., Kimball H., Kobayashi A., Krawczyk M.-C., Leyba T., Longmire J.L., Lopez F., Lou Y., Lowry S., Ludeman T., Manohar C.F., Mark G.A., McMurray K.L., Meincke L.J., Morgan J., Moyzis R.K., Mundt M.O., Munk A.C., Nandkeshwar R.D., Pitluck S., Pollard M., Predki P., Parson-Quintana B., Ramirez L., Rash S., Retterer J., Ricke D.O., Robinson D.L., Rodriguez A., Salamov A., Saunders E.H., Scott D., Shough T., Stallings R.L., Stalvey M., Sutherland R.D., Tapia R., Tesmer J.G., Thayer N., Thompson L.S., Tice H., Torney D.C., Tran-Gyamfi M., Tsai M., Ulanovsky L.E., Ustaszewska A., Vo N., White P.S., Williams A.L., Wills P.L., Wu J.-R., Wu K., Yang J., DeJong P., Bruce D., Doggett N.A., Deaven L., Schmutz J., Grimwood J., Richardson P., Rokhsar D.S., Eichler E.E., Gilna P., Lucas S.M., Myers R.M., Rubin E.M., Pennacchio L.A.
      Nature 432:988-994(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Muscle.
    7. "Katanin is responsible for the M-phase microtubule-severing activity in Xenopus eggs."
      McNally F.J., Thomas S.
      Mol. Biol. Cell 9:1847-1861(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: SUBCELLULAR LOCATION.
    8. "Two domains of p80 katanin regulate microtubule severing and spindle pole targeting by p60 katanin."
      McNally K.P., Bazirgan O.A., McNally F.J.
      J. Cell Sci. 113:1623-1633(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, INTERACTION WITH KATNA1.
    9. "Recruitment of katanin p60 by phosphorylated NDEL1, an LIS1 interacting protein, is essential for mitotic cell division and neuronal migration."
      Toyo-Oka K., Sasaki S., Yano Y., Mori D., Kobayashi T., Toyoshima Y.Y., Tokuoka S.M., Ishii S., Shimizu T., Muramatsu M., Hiraiwa N., Yoshiki A., Wynshaw-Boris A., Hirotsune S.
      Hum. Mol. Genet. 14:3113-3128(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH NDEL1, SUBCELLULAR LOCATION.
    10. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiKTNB1_HUMAN
    AccessioniPrimary (citable) accession number: Q9BVA0
    Secondary accession number(s): A6NCG6, O60620
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 1, 2005
    Last sequence update: June 1, 2001
    Last modified: October 1, 2014
    This is version 117 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 16
      Human chromosome 16: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3