ID ZN747_HUMAN Reviewed; 330 AA. AC Q9BV97; A8K827; B7WNU3; B7Z5R0; Q59FB4; Q96NW0; DT 10-JUL-2007, integrated into UniProtKB/Swiss-Prot. DT 23-FEB-2022, sequence version 2. DT 27-MAR-2024, entry version 149. DE RecName: Full=Zinc finger protein 747 {ECO:0000312|HGNC:HGNC:28350}; GN Name=ZNF747 {ECO:0000312|HGNC:HGNC:28350}; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; OC Homo. OX NCBI_TaxID=9606; RN [1] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 2 AND 3). RC TISSUE=Cervix, and Neuroblastoma; RX PubMed=14702039; DOI=10.1038/ng1285; RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S., RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., RA Isogai T., Sugano S.; RT "Complete sequencing and characterization of 21,243 full-length human RT cDNAs."; RL Nat. Genet. 36:40-45(2004). RN [2] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2). RC TISSUE=Brain; RA Totoki Y., Toyoda A., Takeda T., Sakaki Y., Tanaka A., Yokoyama S., RA Ohara O., Nagase T., Kikuno R.F.; RL Submitted (MAR-2005) to the EMBL/GenBank/DDBJ databases. RN [3] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=15616553; DOI=10.1038/nature03187; RA Martin J., Han C., Gordon L.A., Terry A., Prabhakar S., She X., Xie G., RA Hellsten U., Chan Y.M., Altherr M., Couronne O., Aerts A., Bajorek E., RA Black S., Blumer H., Branscomb E., Brown N.C., Bruno W.J., Buckingham J.M., RA Callen D.F., Campbell C.S., Campbell M.L., Campbell E.W., Caoile C., RA Challacombe J.F., Chasteen L.A., Chertkov O., Chi H.C., Christensen M., RA Clark L.M., Cohn J.D., Denys M., Detter J.C., Dickson M., RA Dimitrijevic-Bussod M., Escobar J., Fawcett J.J., Flowers D., Fotopulos D., RA Glavina T., Gomez M., Gonzales E., Goodstein D., Goodwin L.A., Grady D.L., RA Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Hildebrand C.E., RA Huang W., Israni S., Jett J., Jewett P.B., Kadner K., Kimball H., RA Kobayashi A., Krawczyk M.-C., Leyba T., Longmire J.L., Lopez F., Lou Y., RA Lowry S., Ludeman T., Manohar C.F., Mark G.A., McMurray K.L., Meincke L.J., RA Morgan J., Moyzis R.K., Mundt M.O., Munk A.C., Nandkeshwar R.D., RA Pitluck S., Pollard M., Predki P., Parson-Quintana B., Ramirez L., Rash S., RA Retterer J., Ricke D.O., Robinson D.L., Rodriguez A., Salamov A., RA Saunders E.H., Scott D., Shough T., Stallings R.L., Stalvey M., RA Sutherland R.D., Tapia R., Tesmer J.G., Thayer N., Thompson L.S., Tice H., RA Torney D.C., Tran-Gyamfi M., Tsai M., Ulanovsky L.E., Ustaszewska A., RA Vo N., White P.S., Williams A.L., Wills P.L., Wu J.-R., Wu K., Yang J., RA DeJong P., Bruce D., Doggett N.A., Deaven L., Schmutz J., Grimwood J., RA Richardson P., Rokhsar D.S., Eichler E.E., Gilna P., Lucas S.M., RA Myers R.M., Rubin E.M., Pennacchio L.A.; RT "The sequence and analysis of duplication-rich human chromosome 16."; RL Nature 432:988-994(2004). RN [4] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., RA Hunkapiller M.W., Myers E.W., Venter J.C.; RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases. RN [5] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). RC TISSUE=Skin; RX PubMed=15489334; DOI=10.1101/gr.2596504; RG The MGC Project Team; RT "The status, quality, and expansion of the NIH full-length cDNA project: RT the Mammalian Gene Collection (MGC)."; RL Genome Res. 14:2121-2127(2004). CC -!- INTERACTION: CC Q9BV97; Q92624: APPBP2; NbExp=3; IntAct=EBI-4395497, EBI-743771; CC Q9BV97; Q0VD86: INCA1; NbExp=3; IntAct=EBI-4395497, EBI-6509505; CC Q9BV97; Q9UMX1: SUFU; NbExp=6; IntAct=EBI-4395497, EBI-740595; CC -!- ALTERNATIVE PRODUCTS: CC Event=Alternative splicing; Named isoforms=3; CC Name=3; CC IsoId=Q9BV97-3; Sequence=Displayed; CC Name=1; CC IsoId=Q9BV97-1; Sequence=VSP_061285; CC Name=2; CC IsoId=Q9BV97-2; Sequence=VSP_061286; CC -!- SEQUENCE CAUTION: CC Sequence=BAB70760.1; Type=Erroneous termination; Note=Truncated C-terminus.; Evidence={ECO:0000305}; CC Sequence=BAD92783.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305}; CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AK054567; BAB70760.1; ALT_SEQ; mRNA. DR EMBL; AK292192; BAF84881.1; -; mRNA. DR EMBL; AK299308; BAH12996.1; -; mRNA. DR EMBL; AB209546; BAD92783.1; ALT_INIT; mRNA. DR EMBL; AC002310; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; CH471192; EAW52239.1; -; Genomic_DNA. DR EMBL; BC001361; AAH01361.1; -; mRNA. DR CCDS; CCDS10682.1; -. [Q9BV97-1] DR CCDS; CCDS76855.1; -. [Q9BV97-2] DR CCDS; CCDS76856.1; -. [Q9BV97-3] DR RefSeq; NP_001291947.1; NM_001305018.1. DR RefSeq; NP_001291948.1; NM_001305019.1. [Q9BV97-3] DR RefSeq; NP_001291949.1; NM_001305020.1. [Q9BV97-2] DR RefSeq; NP_076420.1; NM_023931.3. [Q9BV97-1] DR AlphaFoldDB; Q9BV97; -. DR SMR; Q9BV97; -. DR BioGRID; 122437; 43. DR IntAct; Q9BV97; 14. DR MINT; Q9BV97; -. DR STRING; 9606.ENSP00000457274; -. DR PhosphoSitePlus; Q9BV97; -. DR BioMuta; ZNF747; -. DR DMDM; 74733300; -. DR MassIVE; Q9BV97; -. DR PaxDb; 9606-ENSP00000455659; -. DR PeptideAtlas; Q9BV97; -. DR ProteomicsDB; 6711; -. DR ProteomicsDB; 79186; -. [Q9BV97-1] DR ProteomicsDB; 79187; -. [Q9BV97-2] DR Antibodypedia; 27341; 92 antibodies from 16 providers. DR DNASU; 65988; -. DR Ensembl; ENST00000252799.3; ENSP00000252799.3; ENSG00000169955.8. [Q9BV97-1] DR Ensembl; ENST00000395094.3; ENSP00000378528.3; ENSG00000169955.8. [Q9BV97-2] DR Ensembl; ENST00000568028.1; ENSP00000457274.1; ENSG00000169955.8. [Q9BV97-3] DR GeneID; 65988; -. DR KEGG; hsa:65988; -. DR UCSC; uc002dyn.4; human. [Q9BV97-3] DR UCSC; uc059tfh.1; human. DR AGR; HGNC:28350; -. DR CTD; 65988; -. DR GeneCards; ZNF747; -. DR HGNC; HGNC:28350; ZNF747. DR HPA; ENSG00000169955; Low tissue specificity. DR neXtProt; NX_Q9BV97; -. DR OpenTargets; ENSG00000169955; -. DR PharmGKB; PA144596521; -. DR VEuPathDB; HostDB:ENSG00000169955; -. DR VEuPathDB; HostDB:ENSG00000261459; -. DR eggNOG; KOG1721; Eukaryota. DR GeneTree; ENSGT00940000160032; -. DR HOGENOM; CLU_002678_13_2_1; -. DR InParanoid; Q9BV97; -. DR OMA; NRAGPEC; -. DR OrthoDB; 5253855at2759; -. DR PhylomeDB; Q9BV97; -. DR TreeFam; TF337922; -. DR TreeFam; TF341914; -. DR PathwayCommons; Q9BV97; -. DR Reactome; R-HSA-212436; Generic Transcription Pathway. DR SignaLink; Q9BV97; -. DR BioGRID-ORCS; 65988; 18 hits in 1161 CRISPR screens. DR GenomeRNAi; 65988; -. DR Pharos; Q9BV97; Tdark. DR PRO; PR:Q9BV97; -. DR Proteomes; UP000005640; Chromosome 16. DR RNAct; Q9BV97; Protein. DR Bgee; ENSG00000169955; Expressed in olfactory bulb and 172 other cell types or tissues. DR ExpressionAtlas; Q9BV97; baseline and differential. DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW. DR GO; GO:0006355; P:regulation of DNA-templated transcription; IEA:InterPro. DR CDD; cd07765; KRAB_A-box; 1. DR Gene3D; 6.10.140.140; -; 1. DR Gene3D; 3.30.160.60; Classic Zinc Finger; 4. DR InterPro; IPR001909; KRAB. DR InterPro; IPR036051; KRAB_dom_sf. DR InterPro; IPR036236; Znf_C2H2_sf. DR InterPro; IPR013087; Znf_C2H2_type. DR PANTHER; PTHR23232; KRAB DOMAIN C2H2 ZINC FINGER; 1. DR PANTHER; PTHR23232:SF143; ZINC FINGER PROTEIN 747; 1. DR Pfam; PF01352; KRAB; 1. DR Pfam; PF00096; zf-C2H2; 2. DR SMART; SM00349; KRAB; 1. DR SMART; SM00355; ZnF_C2H2; 4. DR SUPFAM; SSF57667; beta-beta-alpha zinc fingers; 2. DR SUPFAM; SSF109640; KRAB domain (Kruppel-associated box); 1. DR PROSITE; PS50805; KRAB; 1. DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 4. DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 4. DR Genevisible; Q9BV97; HS. PE 1: Evidence at protein level; KW Alternative splicing; Metal-binding; Reference proteome; Repeat; Zinc; KW Zinc-finger. FT CHAIN 1..330 FT /note="Zinc finger protein 747" FT /id="PRO_0000293691" FT DOMAIN 37..108 FT /note="KRAB" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00119" FT ZN_FING 181..203 FT /note="C2H2-type 1" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042" FT ZN_FING 209..231 FT /note="C2H2-type 2" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042" FT ZN_FING 237..259 FT /note="C2H2-type 3" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042" FT ZN_FING 265..287 FT /note="C2H2-type 4" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042" FT REGION 1..32 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT REGION 99..150 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 108..130 FT /note="Basic and acidic residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT VAR_SEQ 78..329 FT /note="VGGSKPALISWVEEKAELWDPAAQDPEVAKCPTEADPDSRNKEEERQREGTG FT ALEKPDPVAAGSPGLKAPQAPFAGLEQLSKARRRSRPRFFAHPPVPRADQRHGCYVCGK FT SFAWRSTLVEHIYSHRGEKPFHCADCGKGFGHASSLSKHRAIHRGERPHRCPECGRAFM FT RRTALTSHLRVHTGEKPYRCPQCGRCFGLKTGMAKHQWVHRPGGEGRRGRRPGGLSVTL FT TPVRGDLDPPVGFQLYPEIFQEC -> ESPTCLPGPCASTGPAAPLGAACGVGGPGAGQ FT AASSQRGVCVLLPQESEAASRRSSPGWRRRPNCGIRLPRIRRWRSVRQKRTQQIPETRK FT RKDKGKGREPWRSPTLWPPGLL (in isoform 1)" FT /id="VSP_061285" FT VAR_SEQ 78..329 FT /note="VGGSKPALISWVEEKAELWDPAAQDPEVAKCPTEADPDSRNKEEERQREGTG FT ALEKPDPVAAGSPGLKAPQAPFAGLEQLSKARRRSRPRFFAHPPVPRADQRHGCYVCGK FT SFAWRSTLVEHIYSHRGEKPFHCADCGKGFGHASSLSKHRAIHRGERPHRCPECGRAFM FT RRTALTSHLRVHTGEKPYRCPQCGRCFGLKTGMAKHQWVHRPGGEGRRGRRPGGLSVTL FT TPVRGDLDPPVGFQLYPEIFQEC -> ESPTCLPGPCASTGPAAPLGAACGVGGPGAGQ FT AASSQRGVCVLLPQESEAASRRSSPGWRRRPNCGIRLPRIRRWRSVRQKRTQIPETRKR FT KDKGKGREPWRSPTLWPPGLL (in isoform 2)" FT /id="VSP_061286" FT CONFLICT 27 FT /note="A -> V (in Ref. 1; BAB70760)" FT /evidence="ECO:0000305" SQ SEQUENCE 330 AA; 36399 MW; AD9C9CF3844E08AD CRC64; MTDPSLGLTV PMAPPLAPLP PRDPNGAGSE WRKPGAVSFA DVAVYFSREE WGCLRPAQRA LYRDVMRETY GHLGALGVGG SKPALISWVE EKAELWDPAA QDPEVAKCPT EADPDSRNKE EERQREGTGA LEKPDPVAAG SPGLKAPQAP FAGLEQLSKA RRRSRPRFFA HPPVPRADQR HGCYVCGKSF AWRSTLVEHI YSHRGEKPFH CADCGKGFGH ASSLSKHRAI HRGERPHRCP ECGRAFMRRT ALTSHLRVHT GEKPYRCPQC GRCFGLKTGM AKHQWVHRPG GEGRRGRRPG GLSVTLTPVR GDLDPPVGFQ LYPEIFQECG //