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Q9BV97

- ZN747_HUMAN

UniProt

Q9BV97 - ZN747_HUMAN

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Protein

KRAB domain-containing protein ZNF747

Gene

ZNF747

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  1. nucleic acid binding Source: InterPro

GO - Biological processi

  1. regulation of transcription, DNA-templated Source: InterPro
Complete GO annotation...

Enzyme and pathway databases

ReactomeiREACT_12627. Generic Transcription Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
KRAB domain-containing protein ZNF747
Gene namesi
Name:ZNF747
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 16

Organism-specific databases

HGNCiHGNC:28350. ZNF747.

Subcellular locationi

GO - Cellular componenti

  1. intracellular Source: InterPro
Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA144596521.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 191191KRAB domain-containing protein ZNF747PRO_0000293691Add
BLAST

Proteomic databases

PaxDbiQ9BV97.
PRIDEiQ9BV97.

Expressioni

Gene expression databases

BgeeiQ9BV97.
CleanExiHS_ZNF747.
ExpressionAtlasiQ9BV97. baseline and differential.
GenevestigatoriQ9BV97.

Interactioni

Protein-protein interaction databases

BioGridi122437. 5 interactions.
IntActiQ9BV97. 2 interactions.
MINTiMINT-8201754.
STRINGi9606.ENSP00000252799.

Structurei

3D structure databases

ProteinModelPortaliQ9BV97.
SMRiQ9BV97. Positions 32-79.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini37 – 140104KRABPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 KRAB domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiCOG5048.
GeneTreeiENSGT00560000077257.
HOGENOMiHOG000013151.
InParanoidiQ9BV97.
OMAiCDIGRAL.
OrthoDBiEOG7JT6XW.
PhylomeDBiQ9BV97.
TreeFamiTF341914.

Family and domain databases

InterProiIPR026613. KRAB_dom_C2H2_Znf_fam.
IPR001909. Krueppel-associated_box.
[Graphical view]
PANTHERiPTHR23232. PTHR23232. 1 hit.
PfamiPF01352. KRAB. 1 hit.
[Graphical view]
SMARTiSM00349. KRAB. 1 hit.
[Graphical view]
SUPFAMiSSF109640. SSF109640. 1 hit.
PROSITEiPS50805. KRAB. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q9BV97-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MTDPSLGLTV PMAPPLAPLP PRDPNGAGSE WRKPGAVSFA DVAVYFSREE
60 70 80 90 100
WGCLRPAQRA LYRDVMRETY GHLGALGESP TCLPGPCAST GPAAPLGAAC
110 120 130 140 150
GVGGPGAGQA ASSQRGVCVL LPQESEAASR RSSPGWRRRP NCGIRLPRIR
160 170 180 190
RWRSVRQKRT QQIPETRKRK DKGKGREPWR SPTLWPPGLL G
Length:191
Mass (Da):20,610
Last modified:June 1, 2001 - v1
Checksum:iD5B7F82D15E2BDF6
GO
Isoform 2 (identifier: Q9BV97-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     162-162: Missing.

Show »
Length:190
Mass (Da):20,482
Checksum:i834970AEF8630C47
GO

Sequence cautioni

The sequence BAB70760.1 differs from that shown. Reason: Erroneous termination at position 172. Translated as Lys.

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti27 – 271A → V in BAB70760. (PubMed:14702039)Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei162 – 1621Missing in isoform 2. 2 PublicationsVSP_026557

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK054567 mRNA. Translation: BAB70760.1. Sequence problems.
AK292192 mRNA. Translation: BAF84881.1.
AB209546 mRNA. Translation: BAD92783.1.
AC002310 Genomic DNA. No translation available.
CH471192 Genomic DNA. Translation: EAW52239.1.
BC001361 mRNA. Translation: AAH01361.1.
CCDSiCCDS10682.1. [Q9BV97-1]
RefSeqiNP_076420.1. NM_023931.2. [Q9BV97-1]
UniGeneiHs.592032.

Genome annotation databases

EnsembliENST00000252799; ENSP00000252799; ENSG00000169955. [Q9BV97-1]
ENST00000395094; ENSP00000378528; ENSG00000169955. [Q9BV97-2]
GeneIDi65988.
KEGGihsa:65988.
UCSCiuc002dyn.3. human. [Q9BV97-1]
uc002dyo.1. human. [Q9BV97-2]

Polymorphism databases

DMDMi74733300.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK054567 mRNA. Translation: BAB70760.1 . Sequence problems.
AK292192 mRNA. Translation: BAF84881.1 .
AB209546 mRNA. Translation: BAD92783.1 .
AC002310 Genomic DNA. No translation available.
CH471192 Genomic DNA. Translation: EAW52239.1 .
BC001361 mRNA. Translation: AAH01361.1 .
CCDSi CCDS10682.1. [Q9BV97-1 ]
RefSeqi NP_076420.1. NM_023931.2. [Q9BV97-1 ]
UniGenei Hs.592032.

3D structure databases

ProteinModelPortali Q9BV97.
SMRi Q9BV97. Positions 32-79.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 122437. 5 interactions.
IntActi Q9BV97. 2 interactions.
MINTi MINT-8201754.
STRINGi 9606.ENSP00000252799.

Polymorphism databases

DMDMi 74733300.

Proteomic databases

PaxDbi Q9BV97.
PRIDEi Q9BV97.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000252799 ; ENSP00000252799 ; ENSG00000169955 . [Q9BV97-1 ]
ENST00000395094 ; ENSP00000378528 ; ENSG00000169955 . [Q9BV97-2 ]
GeneIDi 65988.
KEGGi hsa:65988.
UCSCi uc002dyn.3. human. [Q9BV97-1 ]
uc002dyo.1. human. [Q9BV97-2 ]

Organism-specific databases

CTDi 65988.
GeneCardsi GC16M030541.
HGNCi HGNC:28350. ZNF747.
neXtProti NX_Q9BV97.
PharmGKBi PA144596521.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG5048.
GeneTreei ENSGT00560000077257.
HOGENOMi HOG000013151.
InParanoidi Q9BV97.
OMAi CDIGRAL.
OrthoDBi EOG7JT6XW.
PhylomeDBi Q9BV97.
TreeFami TF341914.

Enzyme and pathway databases

Reactomei REACT_12627. Generic Transcription Pathway.

Miscellaneous databases

GenomeRNAii 65988.
NextBioi 67463.
PROi Q9BV97.

Gene expression databases

Bgeei Q9BV97.
CleanExi HS_ZNF747.
ExpressionAtlasi Q9BV97. baseline and differential.
Genevestigatori Q9BV97.

Family and domain databases

InterProi IPR026613. KRAB_dom_C2H2_Znf_fam.
IPR001909. Krueppel-associated_box.
[Graphical view ]
PANTHERi PTHR23232. PTHR23232. 1 hit.
Pfami PF01352. KRAB. 1 hit.
[Graphical view ]
SMARTi SM00349. KRAB. 1 hit.
[Graphical view ]
SUPFAMi SSF109640. SSF109640. 1 hit.
PROSITEi PS50805. KRAB. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
    Tissue: Cervix and Neuroblastoma.
  2. Totoki Y., Toyoda A., Takeda T., Sakaki Y., Tanaka A., Yokoyama S., Ohara O., Nagase T., Kikuno R.F.
    Submitted (MAR-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Brain.
  3. "The sequence and analysis of duplication-rich human chromosome 16."
    Martin J., Han C., Gordon L.A., Terry A., Prabhakar S., She X., Xie G., Hellsten U., Chan Y.M., Altherr M., Couronne O., Aerts A., Bajorek E., Black S., Blumer H., Branscomb E., Brown N.C., Bruno W.J.
    , Buckingham J.M., Callen D.F., Campbell C.S., Campbell M.L., Campbell E.W., Caoile C., Challacombe J.F., Chasteen L.A., Chertkov O., Chi H.C., Christensen M., Clark L.M., Cohn J.D., Denys M., Detter J.C., Dickson M., Dimitrijevic-Bussod M., Escobar J., Fawcett J.J., Flowers D., Fotopulos D., Glavina T., Gomez M., Gonzales E., Goodstein D., Goodwin L.A., Grady D.L., Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Hildebrand C.E., Huang W., Israni S., Jett J., Jewett P.B., Kadner K., Kimball H., Kobayashi A., Krawczyk M.-C., Leyba T., Longmire J.L., Lopez F., Lou Y., Lowry S., Ludeman T., Manohar C.F., Mark G.A., McMurray K.L., Meincke L.J., Morgan J., Moyzis R.K., Mundt M.O., Munk A.C., Nandkeshwar R.D., Pitluck S., Pollard M., Predki P., Parson-Quintana B., Ramirez L., Rash S., Retterer J., Ricke D.O., Robinson D.L., Rodriguez A., Salamov A., Saunders E.H., Scott D., Shough T., Stallings R.L., Stalvey M., Sutherland R.D., Tapia R., Tesmer J.G., Thayer N., Thompson L.S., Tice H., Torney D.C., Tran-Gyamfi M., Tsai M., Ulanovsky L.E., Ustaszewska A., Vo N., White P.S., Williams A.L., Wills P.L., Wu J.-R., Wu K., Yang J., DeJong P., Bruce D., Doggett N.A., Deaven L., Schmutz J., Grimwood J., Richardson P., Rokhsar D.S., Eichler E.E., Gilna P., Lucas S.M., Myers R.M., Rubin E.M., Pennacchio L.A.
    Nature 432:988-994(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Skin.

Entry informationi

Entry nameiZN747_HUMAN
AccessioniPrimary (citable) accession number: Q9BV97
Secondary accession number(s): A8K827
, B7WNU3, Q59FB4, Q96NW0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 10, 2007
Last sequence update: June 1, 2001
Last modified: October 29, 2014
This is version 92 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

Despite its name, it does not contain a canonical C2H2-type zinc-finger.Curated

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3