Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

KRAB domain-containing protein ZNF747

Gene

ZNF747

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Enzyme and pathway databases

ReactomeiREACT_12627. Generic Transcription Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
KRAB domain-containing protein ZNF747
Gene namesi
Name:ZNF747
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 16

Organism-specific databases

HGNCiHGNC:28350. ZNF747.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA144596521.

Polymorphism and mutation databases

BioMutaiZNF747.
DMDMi74733300.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 191191KRAB domain-containing protein ZNF747PRO_0000293691Add
BLAST

Proteomic databases

PaxDbiQ9BV97.
PRIDEiQ9BV97.

Expressioni

Gene expression databases

BgeeiQ9BV97.
CleanExiHS_ZNF747.
ExpressionAtlasiQ9BV97. baseline and differential.
GenevisibleiQ9BV97. HS.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
APPBP2Q926243EBI-4395497,EBI-743771
SUFUQ9UMX13EBI-4395497,EBI-740595

Protein-protein interaction databases

BioGridi122437. 6 interactions.
IntActiQ9BV97. 4 interactions.
MINTiMINT-8201754.
STRINGi9606.ENSP00000252799.

Structurei

3D structure databases

ProteinModelPortaliQ9BV97.
SMRiQ9BV97. Positions 32-79.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini37 – 140104KRABPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 KRAB domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiCOG5048.
GeneTreeiENSGT00560000077257.
HOGENOMiHOG000013151.
InParanoidiQ9BV97.
OrthoDBiEOG7JT6XW.
PhylomeDBiQ9BV97.
TreeFamiTF341914.

Family and domain databases

InterProiIPR026613. KRAB_dom_C2H2_Znf_fam.
IPR001909. Krueppel-associated_box.
[Graphical view]
PANTHERiPTHR23232. PTHR23232. 1 hit.
PfamiPF01352. KRAB. 1 hit.
[Graphical view]
SMARTiSM00349. KRAB. 1 hit.
[Graphical view]
SUPFAMiSSF109640. SSF109640. 1 hit.
PROSITEiPS50805. KRAB. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9BV97-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MTDPSLGLTV PMAPPLAPLP PRDPNGAGSE WRKPGAVSFA DVAVYFSREE
60 70 80 90 100
WGCLRPAQRA LYRDVMRETY GHLGALGESP TCLPGPCAST GPAAPLGAAC
110 120 130 140 150
GVGGPGAGQA ASSQRGVCVL LPQESEAASR RSSPGWRRRP NCGIRLPRIR
160 170 180 190
RWRSVRQKRT QQIPETRKRK DKGKGREPWR SPTLWPPGLL G
Length:191
Mass (Da):20,610
Last modified:June 1, 2001 - v1
Checksum:iD5B7F82D15E2BDF6
GO
Isoform 2 (identifier: Q9BV97-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     162-162: Missing.

Show »
Length:190
Mass (Da):20,482
Checksum:i834970AEF8630C47
GO

Sequence cautioni

The sequence BAB70760.1 differs from that shown. Reason: Erroneous termination at position 172. Translated as Lys.Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti27 – 271A → V in BAB70760 (PubMed:14702039).Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei162 – 1621Missing in isoform 2. 2 PublicationsVSP_026557

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK054567 mRNA. Translation: BAB70760.1. Sequence problems.
AK292192 mRNA. Translation: BAF84881.1.
AB209546 mRNA. Translation: BAD92783.1.
AC002310 Genomic DNA. No translation available.
CH471192 Genomic DNA. Translation: EAW52239.1.
BC001361 mRNA. Translation: AAH01361.1.
CCDSiCCDS10682.1. [Q9BV97-1]
RefSeqiNP_076420.1. NM_023931.3. [Q9BV97-1]
UniGeneiHs.592032.
Hs.625026.

Genome annotation databases

EnsembliENST00000252799; ENSP00000252799; ENSG00000169955. [Q9BV97-1]
ENST00000395094; ENSP00000378528; ENSG00000169955. [Q9BV97-2]
GeneIDi65988.
KEGGihsa:65988.
UCSCiuc002dyn.3. human. [Q9BV97-1]
uc002dyo.1. human. [Q9BV97-2]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK054567 mRNA. Translation: BAB70760.1. Sequence problems.
AK292192 mRNA. Translation: BAF84881.1.
AB209546 mRNA. Translation: BAD92783.1.
AC002310 Genomic DNA. No translation available.
CH471192 Genomic DNA. Translation: EAW52239.1.
BC001361 mRNA. Translation: AAH01361.1.
CCDSiCCDS10682.1. [Q9BV97-1]
RefSeqiNP_076420.1. NM_023931.3. [Q9BV97-1]
UniGeneiHs.592032.
Hs.625026.

3D structure databases

ProteinModelPortaliQ9BV97.
SMRiQ9BV97. Positions 32-79.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi122437. 6 interactions.
IntActiQ9BV97. 4 interactions.
MINTiMINT-8201754.
STRINGi9606.ENSP00000252799.

Polymorphism and mutation databases

BioMutaiZNF747.
DMDMi74733300.

Proteomic databases

PaxDbiQ9BV97.
PRIDEiQ9BV97.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000252799; ENSP00000252799; ENSG00000169955. [Q9BV97-1]
ENST00000395094; ENSP00000378528; ENSG00000169955. [Q9BV97-2]
GeneIDi65988.
KEGGihsa:65988.
UCSCiuc002dyn.3. human. [Q9BV97-1]
uc002dyo.1. human. [Q9BV97-2]

Organism-specific databases

CTDi65988.
GeneCardsiGC16M030541.
HGNCiHGNC:28350. ZNF747.
neXtProtiNX_Q9BV97.
PharmGKBiPA144596521.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiCOG5048.
GeneTreeiENSGT00560000077257.
HOGENOMiHOG000013151.
InParanoidiQ9BV97.
OrthoDBiEOG7JT6XW.
PhylomeDBiQ9BV97.
TreeFamiTF341914.

Enzyme and pathway databases

ReactomeiREACT_12627. Generic Transcription Pathway.

Miscellaneous databases

GenomeRNAii65988.
NextBioi67463.
PROiQ9BV97.

Gene expression databases

BgeeiQ9BV97.
CleanExiHS_ZNF747.
ExpressionAtlasiQ9BV97. baseline and differential.
GenevisibleiQ9BV97. HS.

Family and domain databases

InterProiIPR026613. KRAB_dom_C2H2_Znf_fam.
IPR001909. Krueppel-associated_box.
[Graphical view]
PANTHERiPTHR23232. PTHR23232. 1 hit.
PfamiPF01352. KRAB. 1 hit.
[Graphical view]
SMARTiSM00349. KRAB. 1 hit.
[Graphical view]
SUPFAMiSSF109640. SSF109640. 1 hit.
PROSITEiPS50805. KRAB. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
    Tissue: Cervix and Neuroblastoma.
  2. Totoki Y., Toyoda A., Takeda T., Sakaki Y., Tanaka A., Yokoyama S., Ohara O., Nagase T., Kikuno R.F.
    Submitted (MAR-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Brain.
  3. "The sequence and analysis of duplication-rich human chromosome 16."
    Martin J., Han C., Gordon L.A., Terry A., Prabhakar S., She X., Xie G., Hellsten U., Chan Y.M., Altherr M., Couronne O., Aerts A., Bajorek E., Black S., Blumer H., Branscomb E., Brown N.C., Bruno W.J.
    , Buckingham J.M., Callen D.F., Campbell C.S., Campbell M.L., Campbell E.W., Caoile C., Challacombe J.F., Chasteen L.A., Chertkov O., Chi H.C., Christensen M., Clark L.M., Cohn J.D., Denys M., Detter J.C., Dickson M., Dimitrijevic-Bussod M., Escobar J., Fawcett J.J., Flowers D., Fotopulos D., Glavina T., Gomez M., Gonzales E., Goodstein D., Goodwin L.A., Grady D.L., Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Hildebrand C.E., Huang W., Israni S., Jett J., Jewett P.B., Kadner K., Kimball H., Kobayashi A., Krawczyk M.-C., Leyba T., Longmire J.L., Lopez F., Lou Y., Lowry S., Ludeman T., Manohar C.F., Mark G.A., McMurray K.L., Meincke L.J., Morgan J., Moyzis R.K., Mundt M.O., Munk A.C., Nandkeshwar R.D., Pitluck S., Pollard M., Predki P., Parson-Quintana B., Ramirez L., Rash S., Retterer J., Ricke D.O., Robinson D.L., Rodriguez A., Salamov A., Saunders E.H., Scott D., Shough T., Stallings R.L., Stalvey M., Sutherland R.D., Tapia R., Tesmer J.G., Thayer N., Thompson L.S., Tice H., Torney D.C., Tran-Gyamfi M., Tsai M., Ulanovsky L.E., Ustaszewska A., Vo N., White P.S., Williams A.L., Wills P.L., Wu J.-R., Wu K., Yang J., DeJong P., Bruce D., Doggett N.A., Deaven L., Schmutz J., Grimwood J., Richardson P., Rokhsar D.S., Eichler E.E., Gilna P., Lucas S.M., Myers R.M., Rubin E.M., Pennacchio L.A.
    Nature 432:988-994(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Skin.

Entry informationi

Entry nameiZN747_HUMAN
AccessioniPrimary (citable) accession number: Q9BV97
Secondary accession number(s): A8K827
, B7WNU3, Q59FB4, Q96NW0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 10, 2007
Last sequence update: June 1, 2001
Last modified: June 24, 2015
This is version 97 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

Despite its name, it does not contain a canonical C2H2-type zinc-finger.Curated

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.