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Protein

KRAB domain-containing protein ZNF747

Gene

ZNF747

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Caution

Despite its name, it does not contain a canonical C2H2-type zinc-finger.Curated

GO - Molecular functioni

Enzyme and pathway databases

ReactomeiR-HSA-212436 Generic Transcription Pathway

Names & Taxonomyi

Protein namesi
Recommended name:
KRAB domain-containing protein ZNF747
Gene namesi
Name:ZNF747
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 16

Organism-specific databases

EuPathDBiHostDB:ENSG00000169955.7
HGNCiHGNC:28350 ZNF747
neXtProtiNX_Q9BV97

Subcellular locationi

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000169955
PharmGKBiPA144596521

Polymorphism and mutation databases

BioMutaiZNF747
DMDMi74733300

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002936911 – 191KRAB domain-containing protein ZNF747Add BLAST191

Proteomic databases

PaxDbiQ9BV97
PRIDEiQ9BV97

Expressioni

Gene expression databases

BgeeiENSG00000169955
CleanExiHS_ZNF747
ExpressionAtlasiQ9BV97 baseline and differential
GenevisibleiQ9BV97 HS

Organism-specific databases

HPAiHPA069173

Interactioni

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi122437, 16 interactors
IntActiQ9BV97, 4 interactors
MINTiQ9BV97
STRINGi9606.ENSP00000252799

Structurei

3D structure databases

ProteinModelPortaliQ9BV97
SMRiQ9BV97
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini37 – 140KRABPROSITE-ProRule annotationAdd BLAST104

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00560000077257
HOGENOMiHOG000013151
InParanoidiQ9BV97
OMAiWRRRPNC
PhylomeDBiQ9BV97
TreeFamiTF341914

Family and domain databases

CDDicd07765 KRAB_A-box, 1 hit
InterProiView protein in InterPro
IPR001909 KRAB
IPR036051 KRAB_dom_sf
PfamiView protein in Pfam
PF01352 KRAB, 1 hit
SMARTiView protein in SMART
SM00349 KRAB, 1 hit
SUPFAMiSSF109640 SSF109640, 1 hit
PROSITEiView protein in PROSITE
PS50805 KRAB, 1 hit

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9BV97-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MTDPSLGLTV PMAPPLAPLP PRDPNGAGSE WRKPGAVSFA DVAVYFSREE
60 70 80 90 100
WGCLRPAQRA LYRDVMRETY GHLGALGESP TCLPGPCAST GPAAPLGAAC
110 120 130 140 150
GVGGPGAGQA ASSQRGVCVL LPQESEAASR RSSPGWRRRP NCGIRLPRIR
160 170 180 190
RWRSVRQKRT QQIPETRKRK DKGKGREPWR SPTLWPPGLL G
Length:191
Mass (Da):20,610
Last modified:June 1, 2001 - v1
Checksum:iD5B7F82D15E2BDF6
GO
Isoform 2 (identifier: Q9BV97-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     162-162: Missing.

Show »
Length:190
Mass (Da):20,482
Checksum:i834970AEF8630C47
GO

Sequence cautioni

The sequence BAB70760 differs from that shown. Reason: Erroneous termination at position 172. Translated as Lys.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti27A → V in BAB70760 (PubMed:14702039).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_026557162Missing in isoform 2. 2 Publications1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK054567 mRNA Translation: BAB70760.1 Sequence problems.
AK292192 mRNA Translation: BAF84881.1
AB209546 mRNA Translation: BAD92783.1
AC002310 Genomic DNA No translation available.
CH471192 Genomic DNA Translation: EAW52239.1
BC001361 mRNA Translation: AAH01361.1
CCDSiCCDS10682.1 [Q9BV97-1]
CCDS76855.1 [Q9BV97-2]
RefSeqiNP_001291947.1, NM_001305018.1
NP_001291948.1, NM_001305019.1
NP_001291949.1, NM_001305020.1 [Q9BV97-2]
NP_076420.1, NM_023931.3 [Q9BV97-1]
UniGeneiHs.592032
Hs.625026

Genome annotation databases

EnsembliENST00000252799; ENSP00000252799; ENSG00000169955 [Q9BV97-1]
ENST00000395094; ENSP00000378528; ENSG00000169955 [Q9BV97-2]
GeneIDi65988
KEGGihsa:65988
UCSCiuc002dyn.4 human [Q9BV97-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiZN747_HUMAN
AccessioniPrimary (citable) accession number: Q9BV97
Secondary accession number(s): A8K827
, B7WNU3, Q59FB4, Q96NW0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 10, 2007
Last sequence update: June 1, 2001
Last modified: May 23, 2018
This is version 114 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM

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