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Protein

KRAB domain-containing protein ZNF747

Gene

ZNF747

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Enzyme and pathway databases

BioCyciZFISH:ENSG00000169955-MONOMER.
ReactomeiR-HSA-212436. Generic Transcription Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
KRAB domain-containing protein ZNF747
Gene namesi
Name:ZNF747
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 16

Organism-specific databases

HGNCiHGNC:28350. ZNF747.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000169955.
PharmGKBiPA144596521.

Polymorphism and mutation databases

BioMutaiZNF747.
DMDMi74733300.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002936911 – 191KRAB domain-containing protein ZNF747Add BLAST191

Proteomic databases

PaxDbiQ9BV97.
PRIDEiQ9BV97.

Expressioni

Gene expression databases

BgeeiENSG00000169955.
CleanExiHS_ZNF747.
ExpressionAtlasiQ9BV97. baseline and differential.
GenevisibleiQ9BV97. HS.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
APPBP2Q926243EBI-4395497,EBI-743771
SUFUQ9UMX13EBI-4395497,EBI-740595

Protein-protein interaction databases

BioGridi122437. 15 interactors.
IntActiQ9BV97. 4 interactors.
MINTiMINT-8201754.
STRINGi9606.ENSP00000252799.

Structurei

3D structure databases

ProteinModelPortaliQ9BV97.
SMRiQ9BV97.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini37 – 140KRABPROSITE-ProRule annotationAdd BLAST104

Sequence similaritiesi

Contains 1 KRAB domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00560000077257.
HOGENOMiHOG000013151.
InParanoidiQ9BV97.
OMAiWRRRPNC.
PhylomeDBiQ9BV97.
TreeFamiTF341914.

Family and domain databases

CDDicd07765. KRAB_A-box. 1 hit.
InterProiIPR001909. KRAB.
IPR026613. KRAB_dom_C2H2_Znf_fam.
[Graphical view]
PANTHERiPTHR23232. PTHR23232. 1 hit.
PfamiPF01352. KRAB. 1 hit.
[Graphical view]
SMARTiSM00349. KRAB. 1 hit.
[Graphical view]
SUPFAMiSSF109640. SSF109640. 1 hit.
PROSITEiPS50805. KRAB. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9BV97-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MTDPSLGLTV PMAPPLAPLP PRDPNGAGSE WRKPGAVSFA DVAVYFSREE
60 70 80 90 100
WGCLRPAQRA LYRDVMRETY GHLGALGESP TCLPGPCAST GPAAPLGAAC
110 120 130 140 150
GVGGPGAGQA ASSQRGVCVL LPQESEAASR RSSPGWRRRP NCGIRLPRIR
160 170 180 190
RWRSVRQKRT QQIPETRKRK DKGKGREPWR SPTLWPPGLL G
Length:191
Mass (Da):20,610
Last modified:June 1, 2001 - v1
Checksum:iD5B7F82D15E2BDF6
GO
Isoform 2 (identifier: Q9BV97-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     162-162: Missing.

Show »
Length:190
Mass (Da):20,482
Checksum:i834970AEF8630C47
GO

Sequence cautioni

The sequence BAB70760 differs from that shown. Reason: Erroneous termination at position 172. Translated as Lys.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti27A → V in BAB70760 (PubMed:14702039).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_026557162Missing in isoform 2. 2 Publications1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK054567 mRNA. Translation: BAB70760.1. Sequence problems.
AK292192 mRNA. Translation: BAF84881.1.
AB209546 mRNA. Translation: BAD92783.1.
AC002310 Genomic DNA. No translation available.
CH471192 Genomic DNA. Translation: EAW52239.1.
BC001361 mRNA. Translation: AAH01361.1.
CCDSiCCDS10682.1. [Q9BV97-1]
CCDS76855.1. [Q9BV97-2]
RefSeqiNP_001291947.1. NM_001305018.1.
NP_001291948.1. NM_001305019.1.
NP_001291949.1. NM_001305020.1. [Q9BV97-2]
NP_076420.1. NM_023931.3. [Q9BV97-1]
UniGeneiHs.592032.
Hs.625026.

Genome annotation databases

EnsembliENST00000252799; ENSP00000252799; ENSG00000169955. [Q9BV97-1]
ENST00000395094; ENSP00000378528; ENSG00000169955. [Q9BV97-2]
GeneIDi65988.
KEGGihsa:65988.
UCSCiuc002dyn.4. human. [Q9BV97-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK054567 mRNA. Translation: BAB70760.1. Sequence problems.
AK292192 mRNA. Translation: BAF84881.1.
AB209546 mRNA. Translation: BAD92783.1.
AC002310 Genomic DNA. No translation available.
CH471192 Genomic DNA. Translation: EAW52239.1.
BC001361 mRNA. Translation: AAH01361.1.
CCDSiCCDS10682.1. [Q9BV97-1]
CCDS76855.1. [Q9BV97-2]
RefSeqiNP_001291947.1. NM_001305018.1.
NP_001291948.1. NM_001305019.1.
NP_001291949.1. NM_001305020.1. [Q9BV97-2]
NP_076420.1. NM_023931.3. [Q9BV97-1]
UniGeneiHs.592032.
Hs.625026.

3D structure databases

ProteinModelPortaliQ9BV97.
SMRiQ9BV97.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi122437. 15 interactors.
IntActiQ9BV97. 4 interactors.
MINTiMINT-8201754.
STRINGi9606.ENSP00000252799.

Polymorphism and mutation databases

BioMutaiZNF747.
DMDMi74733300.

Proteomic databases

PaxDbiQ9BV97.
PRIDEiQ9BV97.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000252799; ENSP00000252799; ENSG00000169955. [Q9BV97-1]
ENST00000395094; ENSP00000378528; ENSG00000169955. [Q9BV97-2]
GeneIDi65988.
KEGGihsa:65988.
UCSCiuc002dyn.4. human. [Q9BV97-1]

Organism-specific databases

CTDi65988.
GeneCardsiZNF747.
HGNCiHGNC:28350. ZNF747.
neXtProtiNX_Q9BV97.
OpenTargetsiENSG00000169955.
PharmGKBiPA144596521.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00560000077257.
HOGENOMiHOG000013151.
InParanoidiQ9BV97.
OMAiWRRRPNC.
PhylomeDBiQ9BV97.
TreeFamiTF341914.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000169955-MONOMER.
ReactomeiR-HSA-212436. Generic Transcription Pathway.

Miscellaneous databases

GenomeRNAii65988.
PROiQ9BV97.

Gene expression databases

BgeeiENSG00000169955.
CleanExiHS_ZNF747.
ExpressionAtlasiQ9BV97. baseline and differential.
GenevisibleiQ9BV97. HS.

Family and domain databases

CDDicd07765. KRAB_A-box. 1 hit.
InterProiIPR001909. KRAB.
IPR026613. KRAB_dom_C2H2_Znf_fam.
[Graphical view]
PANTHERiPTHR23232. PTHR23232. 1 hit.
PfamiPF01352. KRAB. 1 hit.
[Graphical view]
SMARTiSM00349. KRAB. 1 hit.
[Graphical view]
SUPFAMiSSF109640. SSF109640. 1 hit.
PROSITEiPS50805. KRAB. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiZN747_HUMAN
AccessioniPrimary (citable) accession number: Q9BV97
Secondary accession number(s): A8K827
, B7WNU3, Q59FB4, Q96NW0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 10, 2007
Last sequence update: June 1, 2001
Last modified: November 2, 2016
This is version 108 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

Despite its name, it does not contain a canonical C2H2-type zinc-finger.Curated

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.