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Protein

U11/U12 small nuclear ribonucleoprotein 25 kDa protein

Gene

SNRNP25

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

GO - Biological processi

  • mRNA splicing, via spliceosome Source: Reactome
  • RNA splicing Source: HGNC
Complete GO annotation...

Keywords - Biological processi

mRNA processing, mRNA splicing

Enzyme and pathway databases

ReactomeiR-HSA-72165. mRNA Splicing - Minor Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
U11/U12 small nuclear ribonucleoprotein 25 kDa protein
Short name:
U11/U12 snRNP 25 kDa protein
Short name:
U11/U12-25K
Alternative name(s):
Minus-99 protein
Gene namesi
Name:SNRNP25
Synonyms:C16orf33
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 16

Organism-specific databases

HGNCiHGNC:14161. SNRNP25.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: HPA
  • intercellular bridge Source: HPA
  • nucleoplasm Source: HPA
  • nucleus Source: MGI
  • U12-type spliceosomal complex Source: HGNC
Complete GO annotation...

Keywords - Cellular componenti

Nucleus, Spliceosome

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA164726099.

Polymorphism and mutation databases

BioMutaiSNRNP25.
DMDMi68052377.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 132132U11/U12 small nuclear ribonucleoprotein 25 kDa proteinPRO_0000114924Add
BLAST

Proteomic databases

PaxDbiQ9BV90.
PRIDEiQ9BV90.

PTM databases

iPTMnetiQ9BV90.

Expressioni

Gene expression databases

BgeeiQ9BV90.
CleanExiHS_SNRNP25.
ExpressionAtlasiQ9BV90. baseline and differential.
GenevisibleiQ9BV90. HS.

Organism-specific databases

HPAiHPA041183.
HPA044248.

Interactioni

Subunit structurei

Component of the U11/U12 snRNPs that are part of the U12-type spliceosome.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
C11orf57Q6ZUT13EBI-9675976,EBI-3920396
CPSF7Q8N6843EBI-9675976,EBI-746909
EFHC2Q5JST63EBI-9675976,EBI-2349927
KRT31Q153233EBI-9675976,EBI-948001
LHX4Q969G23EBI-9675976,EBI-2865388
LNX1Q8TBB13EBI-9675976,EBI-739832
RELQ048643EBI-9675976,EBI-307352
TRAF2Q129333EBI-9675976,EBI-355744

Protein-protein interaction databases

BioGridi122752. 14 interactions.
IntActiQ9BV90. 9 interactions.
STRINGi9606.ENSP00000372482.

Structurei

3D structure databases

ProteinModelPortaliQ9BV90.
SMRiQ9BV90. Positions 40-132.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini41 – 13292Ubiquitin-likePROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 ubiquitin-like domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiENOG410IW7F. Eukaryota.
ENOG4111HGM. LUCA.
GeneTreeiENSGT00390000002628.
HOGENOMiHOG000232002.
HOVERGENiHBG054397.
InParanoidiQ9BV90.
KOiK13153.
OMAiANECEND.
PhylomeDBiQ9BV90.
TreeFamiTF329506.

Family and domain databases

InterProiIPR029071. Ubiquitin-rel_dom.
IPR000626. Ubiquitin_dom.
[Graphical view]
SUPFAMiSSF54236. SSF54236. 1 hit.
PROSITEiPS50053. UBIQUITIN_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9BV90-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDVFQEGLAM VVQDPLLCDL PIQVTLEEVN SQIALEYGQA MTVRVCKMDG
60 70 80 90 100
EVMPVVVVQS ATVLDLKKAI QRYVQLKQER EGGIQHISWS YVWRTYHLTS
110 120 130
AGEKLTEDRK KLRDYGIRNR DEVSFIKKLR QK
Length:132
Mass (Da):15,270
Last modified:June 1, 2001 - v1
Checksum:iFC1C3FC39611226A
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti106 – 1061T → A in BAB15505 (PubMed:14702039).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK026593 mRNA. Translation: BAB15505.1.
DQ431198 Genomic DNA. Translation: ABD95904.1.
AE006462 Genomic DNA. Translation: AAK61211.1.
BC001381 mRNA. Translation: AAH01381.1.
BC009179 mRNA. Translation: AAH09179.1.
BK005201 mRNA. Translation: DAA05499.1.
CCDSiCCDS10396.1.
RefSeqiNP_078847.1. NM_024571.3.
UniGeneiHs.15277.

Genome annotation databases

EnsembliENST00000383018; ENSP00000372482; ENSG00000161981.
GeneIDi79622.
KEGGihsa:79622.
UCSCiuc059ofp.1. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK026593 mRNA. Translation: BAB15505.1.
DQ431198 Genomic DNA. Translation: ABD95904.1.
AE006462 Genomic DNA. Translation: AAK61211.1.
BC001381 mRNA. Translation: AAH01381.1.
BC009179 mRNA. Translation: AAH09179.1.
BK005201 mRNA. Translation: DAA05499.1.
CCDSiCCDS10396.1.
RefSeqiNP_078847.1. NM_024571.3.
UniGeneiHs.15277.

3D structure databases

ProteinModelPortaliQ9BV90.
SMRiQ9BV90. Positions 40-132.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi122752. 14 interactions.
IntActiQ9BV90. 9 interactions.
STRINGi9606.ENSP00000372482.

PTM databases

iPTMnetiQ9BV90.

Polymorphism and mutation databases

BioMutaiSNRNP25.
DMDMi68052377.

Proteomic databases

PaxDbiQ9BV90.
PRIDEiQ9BV90.

Protocols and materials databases

DNASUi79622.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000383018; ENSP00000372482; ENSG00000161981.
GeneIDi79622.
KEGGihsa:79622.
UCSCiuc059ofp.1. human.

Organism-specific databases

CTDi79622.
GeneCardsiSNRNP25.
HGNCiHGNC:14161. SNRNP25.
HPAiHPA041183.
HPA044248.
neXtProtiNX_Q9BV90.
PharmGKBiPA164726099.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IW7F. Eukaryota.
ENOG4111HGM. LUCA.
GeneTreeiENSGT00390000002628.
HOGENOMiHOG000232002.
HOVERGENiHBG054397.
InParanoidiQ9BV90.
KOiK13153.
OMAiANECEND.
PhylomeDBiQ9BV90.
TreeFamiTF329506.

Enzyme and pathway databases

ReactomeiR-HSA-72165. mRNA Splicing - Minor Pathway.

Miscellaneous databases

ChiTaRSiSNRNP25. human.
GenomeRNAii79622.
PROiQ9BV90.

Gene expression databases

BgeeiQ9BV90.
CleanExiHS_SNRNP25.
ExpressionAtlasiQ9BV90. baseline and differential.
GenevisibleiQ9BV90. HS.

Family and domain databases

InterProiIPR029071. Ubiquitin-rel_dom.
IPR000626. Ubiquitin_dom.
[Graphical view]
SUPFAMiSSF54236. SSF54236. 1 hit.
PROSITEiPS50053. UBIQUITIN_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  2. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  3. "The sequence and analysis of duplication-rich human chromosome 16."
    Martin J., Han C., Gordon L.A., Terry A., Prabhakar S., She X., Xie G., Hellsten U., Chan Y.M., Altherr M., Couronne O., Aerts A., Bajorek E., Black S., Blumer H., Branscomb E., Brown N.C., Bruno W.J.
    , Buckingham J.M., Callen D.F., Campbell C.S., Campbell M.L., Campbell E.W., Caoile C., Challacombe J.F., Chasteen L.A., Chertkov O., Chi H.C., Christensen M., Clark L.M., Cohn J.D., Denys M., Detter J.C., Dickson M., Dimitrijevic-Bussod M., Escobar J., Fawcett J.J., Flowers D., Fotopulos D., Glavina T., Gomez M., Gonzales E., Goodstein D., Goodwin L.A., Grady D.L., Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Hildebrand C.E., Huang W., Israni S., Jett J., Jewett P.B., Kadner K., Kimball H., Kobayashi A., Krawczyk M.-C., Leyba T., Longmire J.L., Lopez F., Lou Y., Lowry S., Ludeman T., Manohar C.F., Mark G.A., McMurray K.L., Meincke L.J., Morgan J., Moyzis R.K., Mundt M.O., Munk A.C., Nandkeshwar R.D., Pitluck S., Pollard M., Predki P., Parson-Quintana B., Ramirez L., Rash S., Retterer J., Ricke D.O., Robinson D.L., Rodriguez A., Salamov A., Saunders E.H., Scott D., Shough T., Stallings R.L., Stalvey M., Sutherland R.D., Tapia R., Tesmer J.G., Thayer N., Thompson L.S., Tice H., Torney D.C., Tran-Gyamfi M., Tsai M., Ulanovsky L.E., Ustaszewska A., Vo N., White P.S., Williams A.L., Wills P.L., Wu J.-R., Wu K., Yang J., DeJong P., Bruce D., Doggett N.A., Deaven L., Schmutz J., Grimwood J., Richardson P., Rokhsar D.S., Eichler E.E., Gilna P., Lucas S.M., Myers R.M., Rubin E.M., Pennacchio L.A.
    Nature 432:988-994(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Colon and Lung.
  5. "The human 18S U11/U12 snRNP contains a set of novel proteins not found in the U2-dependent spliceosome."
    Will C.L., Schneider C., Hossbach M., Urlaub H., Rauhut R., Elbashir S., Tuschl T., Luehrmann R.
    RNA 10:929-941(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION IN A COMPLEX WITH THE U11/U12 SPLICEOSOME, SUBCELLULAR LOCATION, IDENTIFICATION BY MASS SPECTROMETRY.

Entry informationi

Entry nameiSNR25_HUMAN
AccessioniPrimary (citable) accession number: Q9BV90
Secondary accession number(s): Q1W6H3, Q6IEF8, Q9H5W4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 21, 2005
Last sequence update: June 1, 2001
Last modified: June 8, 2016
This is version 114 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

It is uncertain whether Met-1 or Met-10 is the initiator.Curated

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.