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Protein

U11/U12 small nuclear ribonucleoprotein 25 kDa protein

Gene

SNRNP25

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

GO - Biological processi

  • mRNA splicing, via spliceosome Source: Reactome
  • RNA splicing Source: HGNC

Keywordsi

Biological processmRNA processing, mRNA splicing

Enzyme and pathway databases

ReactomeiR-HSA-72165. mRNA Splicing - Minor Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
U11/U12 small nuclear ribonucleoprotein 25 kDa protein
Short name:
U11/U12 snRNP 25 kDa protein
Short name:
U11/U12-25K
Alternative name(s):
Minus-99 protein
Gene namesi
Name:SNRNP25
Synonyms:C16orf33
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 16

Organism-specific databases

EuPathDBiHostDB:ENSG00000161981.10.
HGNCiHGNC:14161. SNRNP25.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus, Spliceosome

Pathology & Biotechi

Organism-specific databases

DisGeNETi79622.
OpenTargetsiENSG00000161981.
PharmGKBiPA164726099.

Polymorphism and mutation databases

BioMutaiSNRNP25.
DMDMi68052377.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001149241 – 132U11/U12 small nuclear ribonucleoprotein 25 kDa proteinAdd BLAST132

Proteomic databases

EPDiQ9BV90.
PaxDbiQ9BV90.
PeptideAtlasiQ9BV90.
PRIDEiQ9BV90.

PTM databases

iPTMnetiQ9BV90.
PhosphoSitePlusiQ9BV90.

Expressioni

Gene expression databases

BgeeiENSG00000161981.
CleanExiHS_SNRNP25.
ExpressionAtlasiQ9BV90. baseline and differential.
GenevisibleiQ9BV90. HS.

Organism-specific databases

HPAiHPA041183.
HPA044248.

Interactioni

Subunit structurei

Component of the U11/U12 snRNPs that are part of the U12-type spliceosome.1 Publication

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi122752. 14 interactors.
CORUMiQ9BV90.
IntActiQ9BV90. 17 interactors.
STRINGi9606.ENSP00000372482.

Structurei

3D structure databases

ProteinModelPortaliQ9BV90.
SMRiQ9BV90.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini41 – 132Ubiquitin-likePROSITE-ProRule annotationAdd BLAST92

Phylogenomic databases

eggNOGiENOG410IW7F. Eukaryota.
ENOG4111HGM. LUCA.
GeneTreeiENSGT00390000002628.
HOGENOMiHOG000232002.
HOVERGENiHBG054397.
InParanoidiQ9BV90.
KOiK13153.
OMAiSWRYVWR.
OrthoDBiEOG091G0WEO.
PhylomeDBiQ9BV90.
TreeFamiTF329506.

Family and domain databases

InterProiView protein in InterPro
IPR029071. Ubiquitin-like_domsf.
IPR000626. Ubiquitin_dom.
SUPFAMiSSF54236. SSF54236. 1 hit.
PROSITEiView protein in PROSITE
PS50053. UBIQUITIN_2. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9BV90-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDVFQEGLAM VVQDPLLCDL PIQVTLEEVN SQIALEYGQA MTVRVCKMDG
60 70 80 90 100
EVMPVVVVQS ATVLDLKKAI QRYVQLKQER EGGIQHISWS YVWRTYHLTS
110 120 130
AGEKLTEDRK KLRDYGIRNR DEVSFIKKLR QK
Length:132
Mass (Da):15,270
Last modified:June 1, 2001 - v1
Checksum:iFC1C3FC39611226A
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti106T → A in BAB15505 (PubMed:14702039).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK026593 mRNA. Translation: BAB15505.1.
DQ431198 Genomic DNA. Translation: ABD95904.1.
AE006462 Genomic DNA. Translation: AAK61211.1.
BC001381 mRNA. Translation: AAH01381.1.
BC009179 mRNA. Translation: AAH09179.1.
BK005201 mRNA. Translation: DAA05499.1.
CCDSiCCDS10396.1.
RefSeqiNP_078847.1. NM_024571.3.
UniGeneiHs.15277.

Genome annotation databases

EnsembliENST00000383018; ENSP00000372482; ENSG00000161981.
GeneIDi79622.
KEGGihsa:79622.
UCSCiuc059ofp.1. human.

Similar proteinsi

Entry informationi

Entry nameiSNR25_HUMAN
AccessioniPrimary (citable) accession number: Q9BV90
Secondary accession number(s): Q1W6H3, Q6IEF8, Q9H5W4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 21, 2005
Last sequence update: June 1, 2001
Last modified: November 22, 2017
This is version 124 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

It is uncertain whether Met-1 or Met-10 is the initiator.Curated

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM