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Q9BV87

- CNPD1_HUMAN

UniProt

Q9BV87 - CNPD1_HUMAN

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Protein
Protein CNPPD1
Gene
CNPPD1, C2orf24, CDABP0125, CGI-57
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

GO - Biological processi

  1. regulation of cyclin-dependent protein serine/threonine kinase activity Source: InterPro
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Protein CNPPD1
Alternative name(s):
Cyclin Pas1/PHO80 domain-containing protein 1
Gene namesi
Name:CNPPD1
Synonyms:C2orf24
ORF Names:CDABP0125, CGI-57
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 2

Organism-specific databases

HGNCiHGNC:25220. CNPPD1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei233 – 25321Helical; Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134874121.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 410410Protein CNPPD1
PRO_0000089352Add
BLAST

Proteomic databases

PaxDbiQ9BV87.
PRIDEiQ9BV87.

PTM databases

PhosphoSiteiQ9BV87.

Expressioni

Gene expression databases

ArrayExpressiQ9BV87.
BgeeiQ9BV87.
CleanExiHS_C2orf24.
GenevestigatoriQ9BV87.

Organism-specific databases

HPAiHPA049303.

Interactioni

Protein-protein interaction databases

BioGridi117955. 1 interaction.

Structurei

3D structure databases

ProteinModelPortaliQ9BV87.
SMRiQ9BV87. Positions 48-232.

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi318 – 38972Pro-rich
Add
BLAST

Sequence similaritiesi

Belongs to the CNPPD1 family.

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG322958.
HOVERGENiHBG054544.
InParanoidiQ9BV87.
OMAiRRRGWYT.
OrthoDBiEOG7T4MKJ.
PhylomeDBiQ9BV87.
TreeFamiTF105853.

Family and domain databases

InterProiIPR013922. Cyclin_PHO80-like.
[Graphical view]
PfamiPF08613. Cyclin. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9BV87-1 [UniParc]FASTAAdd to Basket

« Hide

MDLTGLLLDE EGTFSLAGFQ DFTFLPGHQK LSARIRRRLY YGWDWEADCS    50
LEELSSPVAD IAVELLQKAA PSPIRRLQKK YVAHVSREAC ISPCAMMLAL 100
VYIERLRHRN PDYLQHVSSS DLFLISMMVA SKYLYDEGEE EEVFNDEWGA 150
AGGVAVPTLN ALERGFLSAM DWHLYTDPRE IFEVLSWLES CVAEQQGRWR 200
GWYTYTDLCV LLEQPTWQLA LGSLCQRLVK LSCLLAVAYV SSVALAVASV 250
AVIHQSLGLS CIPTPGPPDL GLTSRCLLEP CIPSVPQCLP SLANVSSCLE 300
GSMGLRSLWG SLLASLTPPP LPPPDPPAPP TLLHNCHLCQ KLQRDSPTCH 350
ACLHPNRTVP TALSSPWYHT YGLAPPWPWS PVLLSLPQPQ QCSLFSVMEL 400
ARLKSFVFPG 410
Length:410
Mass (Da):45,456
Last modified:May 18, 2010 - v2
Checksum:i9C0C75F7BF026C6A
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti262 – 2621I → T.4 Publications
Corresponds to variant rs1043160 [ dbSNP | Ensembl ].
VAR_022825
Natural varianti292 – 2921L → P.4 Publications
Corresponds to variant rs1127102 [ dbSNP | Ensembl ].
VAR_024298
Natural varianti344 – 3441R → T.
Corresponds to variant rs1043161 [ dbSNP | Ensembl ].
VAR_056769
Natural varianti366 – 3661P → L.
Corresponds to variant rs17655123 [ dbSNP | Ensembl ].
VAR_024299
Natural varianti383 – 3831L → P.5 Publications
Corresponds to variant rs4674361 [ dbSNP | Ensembl ].
VAR_024300

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti38 – 381R → G in AAD34052. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF151815 mRNA. Translation: AAD34052.1.
AY007160 mRNA. Translation: AAG02008.1.
AF070638 mRNA. Translation: AAC25393.1.
AK314975 mRNA. Translation: BAG37474.1.
CR457401 mRNA. Translation: CAG33682.1.
AC068946 Genomic DNA. No translation available.
BC001393 mRNA. Translation: AAH01393.1.
BC012821 mRNA. Translation: AAH12821.1.
CCDSiCCDS2433.1.
RefSeqiNP_056495.3. NM_015680.4.
XP_005246519.1. XM_005246462.1.
XP_005246520.1. XM_005246463.2.
XP_006712482.1. XM_006712419.1.
UniGeneiHs.4973.

Genome annotation databases

EnsembliENST00000360507; ENSP00000353698; ENSG00000115649.
ENST00000409789; ENSP00000386277; ENSG00000115649.
GeneIDi27013.
KEGGihsa:27013.
UCSCiuc002vju.4. human.

Polymorphism databases

DMDMi296434422.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF151815 mRNA. Translation: AAD34052.1 .
AY007160 mRNA. Translation: AAG02008.1 .
AF070638 mRNA. Translation: AAC25393.1 .
AK314975 mRNA. Translation: BAG37474.1 .
CR457401 mRNA. Translation: CAG33682.1 .
AC068946 Genomic DNA. No translation available.
BC001393 mRNA. Translation: AAH01393.1 .
BC012821 mRNA. Translation: AAH12821.1 .
CCDSi CCDS2433.1.
RefSeqi NP_056495.3. NM_015680.4.
XP_005246519.1. XM_005246462.1.
XP_005246520.1. XM_005246463.2.
XP_006712482.1. XM_006712419.1.
UniGenei Hs.4973.

3D structure databases

ProteinModelPortali Q9BV87.
SMRi Q9BV87. Positions 48-232.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 117955. 1 interaction.

PTM databases

PhosphoSitei Q9BV87.

Polymorphism databases

DMDMi 296434422.

Proteomic databases

PaxDbi Q9BV87.
PRIDEi Q9BV87.

Protocols and materials databases

DNASUi 27013.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000360507 ; ENSP00000353698 ; ENSG00000115649 .
ENST00000409789 ; ENSP00000386277 ; ENSG00000115649 .
GeneIDi 27013.
KEGGi hsa:27013.
UCSCi uc002vju.4. human.

Organism-specific databases

CTDi 27013.
GeneCardsi GC02M220037.
HGNCi HGNC:25220. CNPPD1.
HPAi HPA049303.
neXtProti NX_Q9BV87.
PharmGKBi PA134874121.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG322958.
HOVERGENi HBG054544.
InParanoidi Q9BV87.
OMAi RRRGWYT.
OrthoDBi EOG7T4MKJ.
PhylomeDBi Q9BV87.
TreeFami TF105853.

Miscellaneous databases

ChiTaRSi CNPPD1. human.
GenomeRNAii 27013.
NextBioi 49528.
PROi Q9BV87.

Gene expression databases

ArrayExpressi Q9BV87.
Bgeei Q9BV87.
CleanExi HS_C2orf24.
Genevestigatori Q9BV87.

Family and domain databases

InterProi IPR013922. Cyclin_PHO80-like.
[Graphical view ]
Pfami PF08613. Cyclin. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics."
    Lai C.-H., Chou C.-Y., Ch'ang L.-Y., Liu C.-S., Lin W.-C.
    Genome Res. 10:703-713(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANTS THR-262; PRO-292 AND PRO-383.
  2. "Pediatric leukemia cDNA sequencing project."
    Zhou J., Yu W., Tang H., Mei G., Tsang Y.T.M., Bouck J., Gibbs R.A., Margolin J.F.
    Submitted (JUL-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT PRO-383.
    Tissue: Leukemia.
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANTS THR-262; PRO-292 AND PRO-383.
    Tissue: Cervix.
  4. "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
    Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.
    Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANTS THR-262; PRO-292 AND PRO-383.
  5. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
    Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H.
    , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
    Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANTS THR-262; PRO-292 AND PRO-383.
    Tissue: Colon and Kidney.

Entry informationi

Entry nameiCNPD1_HUMAN
AccessioniPrimary (citable) accession number: Q9BV87
Secondary accession number(s): B2RC77
, O75548, Q9H4N0, Q9UQN0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 5, 2005
Last sequence update: May 18, 2010
Last modified: July 9, 2014
This is version 96 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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