Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Q9BV87

- CNPD1_HUMAN

UniProt

Q9BV87 - CNPD1_HUMAN

Protein

Protein CNPPD1

Gene

CNPPD1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 97 (01 Oct 2014)
      Sequence version 2 (18 May 2010)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    GO - Biological processi

    1. regulation of cyclin-dependent protein serine/threonine kinase activity Source: InterPro

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Protein CNPPD1
    Alternative name(s):
    Cyclin Pas1/PHO80 domain-containing protein 1
    Gene namesi
    Name:CNPPD1
    Synonyms:C2orf24
    ORF Names:CDABP0125, CGI-57
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 2

    Organism-specific databases

    HGNCiHGNC:25220. CNPPD1.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA134874121.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 410410Protein CNPPD1PRO_0000089352Add
    BLAST

    Proteomic databases

    PaxDbiQ9BV87.
    PRIDEiQ9BV87.

    PTM databases

    PhosphoSiteiQ9BV87.

    Expressioni

    Gene expression databases

    ArrayExpressiQ9BV87.
    BgeeiQ9BV87.
    CleanExiHS_C2orf24.
    GenevestigatoriQ9BV87.

    Organism-specific databases

    HPAiHPA049303.

    Interactioni

    Protein-protein interaction databases

    BioGridi117955. 1 interaction.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9BV87.
    SMRiQ9BV87. Positions 48-232.
    ModBaseiSearch...
    MobiDBiSearch...

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei233 – 25321HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi318 – 38972Pro-richAdd
    BLAST

    Sequence similaritiesi

    Belongs to the CNPPD1 family.Curated

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG322958.
    HOVERGENiHBG054544.
    InParanoidiQ9BV87.
    OMAiRRRGWYT.
    OrthoDBiEOG7T4MKJ.
    PhylomeDBiQ9BV87.
    TreeFamiTF105853.

    Family and domain databases

    InterProiIPR013922. Cyclin_PHO80-like.
    [Graphical view]
    PfamiPF08613. Cyclin. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9BV87-1 [UniParc]FASTAAdd to Basket

    « Hide

    MDLTGLLLDE EGTFSLAGFQ DFTFLPGHQK LSARIRRRLY YGWDWEADCS    50
    LEELSSPVAD IAVELLQKAA PSPIRRLQKK YVAHVSREAC ISPCAMMLAL 100
    VYIERLRHRN PDYLQHVSSS DLFLISMMVA SKYLYDEGEE EEVFNDEWGA 150
    AGGVAVPTLN ALERGFLSAM DWHLYTDPRE IFEVLSWLES CVAEQQGRWR 200
    GWYTYTDLCV LLEQPTWQLA LGSLCQRLVK LSCLLAVAYV SSVALAVASV 250
    AVIHQSLGLS CIPTPGPPDL GLTSRCLLEP CIPSVPQCLP SLANVSSCLE 300
    GSMGLRSLWG SLLASLTPPP LPPPDPPAPP TLLHNCHLCQ KLQRDSPTCH 350
    ACLHPNRTVP TALSSPWYHT YGLAPPWPWS PVLLSLPQPQ QCSLFSVMEL 400
    ARLKSFVFPG 410
    Length:410
    Mass (Da):45,456
    Last modified:May 18, 2010 - v2
    Checksum:i9C0C75F7BF026C6A
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti38 – 381R → G in AAD34052. (PubMed:10810093)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti262 – 2621I → T.4 Publications
    Corresponds to variant rs1043160 [ dbSNP | Ensembl ].
    VAR_022825
    Natural varianti292 – 2921L → P.4 Publications
    Corresponds to variant rs1127102 [ dbSNP | Ensembl ].
    VAR_024298
    Natural varianti344 – 3441R → T.
    Corresponds to variant rs1043161 [ dbSNP | Ensembl ].
    VAR_056769
    Natural varianti366 – 3661P → L.
    Corresponds to variant rs17655123 [ dbSNP | Ensembl ].
    VAR_024299
    Natural varianti383 – 3831L → P.5 Publications
    Corresponds to variant rs4674361 [ dbSNP | Ensembl ].
    VAR_024300

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF151815 mRNA. Translation: AAD34052.1.
    AY007160 mRNA. Translation: AAG02008.1.
    AF070638 mRNA. Translation: AAC25393.1.
    AK314975 mRNA. Translation: BAG37474.1.
    CR457401 mRNA. Translation: CAG33682.1.
    AC068946 Genomic DNA. No translation available.
    BC001393 mRNA. Translation: AAH01393.1.
    BC012821 mRNA. Translation: AAH12821.1.
    CCDSiCCDS2433.1.
    RefSeqiNP_056495.3. NM_015680.4.
    XP_005246519.1. XM_005246462.1.
    XP_005246520.1. XM_005246463.2.
    XP_006712482.1. XM_006712419.1.
    UniGeneiHs.4973.

    Genome annotation databases

    EnsembliENST00000360507; ENSP00000353698; ENSG00000115649.
    ENST00000409789; ENSP00000386277; ENSG00000115649.
    GeneIDi27013.
    KEGGihsa:27013.
    UCSCiuc002vju.4. human.

    Polymorphism databases

    DMDMi296434422.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF151815 mRNA. Translation: AAD34052.1 .
    AY007160 mRNA. Translation: AAG02008.1 .
    AF070638 mRNA. Translation: AAC25393.1 .
    AK314975 mRNA. Translation: BAG37474.1 .
    CR457401 mRNA. Translation: CAG33682.1 .
    AC068946 Genomic DNA. No translation available.
    BC001393 mRNA. Translation: AAH01393.1 .
    BC012821 mRNA. Translation: AAH12821.1 .
    CCDSi CCDS2433.1.
    RefSeqi NP_056495.3. NM_015680.4.
    XP_005246519.1. XM_005246462.1.
    XP_005246520.1. XM_005246463.2.
    XP_006712482.1. XM_006712419.1.
    UniGenei Hs.4973.

    3D structure databases

    ProteinModelPortali Q9BV87.
    SMRi Q9BV87. Positions 48-232.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 117955. 1 interaction.

    PTM databases

    PhosphoSitei Q9BV87.

    Polymorphism databases

    DMDMi 296434422.

    Proteomic databases

    PaxDbi Q9BV87.
    PRIDEi Q9BV87.

    Protocols and materials databases

    DNASUi 27013.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000360507 ; ENSP00000353698 ; ENSG00000115649 .
    ENST00000409789 ; ENSP00000386277 ; ENSG00000115649 .
    GeneIDi 27013.
    KEGGi hsa:27013.
    UCSCi uc002vju.4. human.

    Organism-specific databases

    CTDi 27013.
    GeneCardsi GC02M220037.
    HGNCi HGNC:25220. CNPPD1.
    HPAi HPA049303.
    neXtProti NX_Q9BV87.
    PharmGKBi PA134874121.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG322958.
    HOVERGENi HBG054544.
    InParanoidi Q9BV87.
    OMAi RRRGWYT.
    OrthoDBi EOG7T4MKJ.
    PhylomeDBi Q9BV87.
    TreeFami TF105853.

    Miscellaneous databases

    ChiTaRSi CNPPD1. human.
    GenomeRNAii 27013.
    NextBioi 49528.
    PROi Q9BV87.

    Gene expression databases

    ArrayExpressi Q9BV87.
    Bgeei Q9BV87.
    CleanExi HS_C2orf24.
    Genevestigatori Q9BV87.

    Family and domain databases

    InterProi IPR013922. Cyclin_PHO80-like.
    [Graphical view ]
    Pfami PF08613. Cyclin. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics."
      Lai C.-H., Chou C.-Y., Ch'ang L.-Y., Liu C.-S., Lin W.-C.
      Genome Res. 10:703-713(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANTS THR-262; PRO-292 AND PRO-383.
    2. "Pediatric leukemia cDNA sequencing project."
      Zhou J., Yu W., Tang H., Mei G., Tsang Y.T.M., Bouck J., Gibbs R.A., Margolin J.F.
      Submitted (JUL-2000) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT PRO-383.
      Tissue: Leukemia.
    3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANTS THR-262; PRO-292 AND PRO-383.
      Tissue: Cervix.
    4. "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
      Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.
      Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANTS THR-262; PRO-292 AND PRO-383.
    5. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
      Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H.
      , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
      Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANTS THR-262; PRO-292 AND PRO-383.
      Tissue: Colon and Kidney.

    Entry informationi

    Entry nameiCNPD1_HUMAN
    AccessioniPrimary (citable) accession number: Q9BV87
    Secondary accession number(s): B2RC77
    , O75548, Q9H4N0, Q9UQN0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 5, 2005
    Last sequence update: May 18, 2010
    Last modified: October 1, 2014
    This is version 97 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 2
      Human chromosome 2: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3