Q9BV87 (CNPD1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Protein CNPPD1

Alternative name(s):
Cyclin Pas1/PHO80 domain-containing protein 1

Gene names

Name:	CNPPD1
ORF Names:	C2orf24, CDABP0125, CGI-57

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	410 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Subcellular location	Membrane; Single-pass membrane protein Potential.
Sequence similarities	Belongs to the CNPPD1 family.

Ontologies

Keywords
Cellular component	Membrane
Coding sequence diversity	Polymorphism
Domain	Transmembrane Transmembrane helix
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	regulation of cyclin-dependent protein serine/threonine kinase activity Inferred from electronic annotation. Source: InterPro
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 410	410	Protein CNPPD1		PRO_0000089352
Regions
	Transmembrane	233 – 253	21	Helical; Potential
	Compositional bias	318 – 389	72	Pro-rich
Natural variations
	Natural variant	262	1	I → T. Ref.1 Ref.3 Ref.4 Ref.6 Corresponds to variant rs1043160 [ dbSNP | Ensembl ].		VAR_022825
	Natural variant	292	1	L → P. Ref.1 Ref.3 Ref.4 Ref.6 Corresponds to variant rs1127102 [ dbSNP | Ensembl ].		VAR_024298
	Natural variant	344	1	R → T. Corresponds to variant rs1043161 [ dbSNP | Ensembl ].		VAR_056769
	Natural variant	366	1	P → L. Corresponds to variant rs17655123 [ dbSNP | Ensembl ].		VAR_024299
	Natural variant	383	1	L → P. Ref.1 Ref.2 Ref.3 Ref.4 Ref.6 Corresponds to variant rs4674361 [ dbSNP | Ensembl ].		VAR_024300
Experimental info
	Sequence conflict	38	1	R → G in AAD34052. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	Q9BV87 [UniParc]. Last modified May 18, 2010. Version 2. Checksum: 9C0C75F7BF026C6A	FASTA	410	45,456
	10 20 30 40 50 60 MDLTGLLLDE EGTFSLAGFQ DFTFLPGHQK LSARIRRRLY YGWDWEADCS LEELSSPVAD 70 80 90 100 110 120 IAVELLQKAA PSPIRRLQKK YVAHVSREAC ISPCAMMLAL VYIERLRHRN PDYLQHVSSS 130 140 150 160 170 180 DLFLISMMVA SKYLYDEGEE EEVFNDEWGA AGGVAVPTLN ALERGFLSAM DWHLYTDPRE 190 200 210 220 230 240 IFEVLSWLES CVAEQQGRWR GWYTYTDLCV LLEQPTWQLA LGSLCQRLVK LSCLLAVAYV 250 260 270 280 290 300 SSVALAVASV AVIHQSLGLS CIPTPGPPDL GLTSRCLLEP CIPSVPQCLP SLANVSSCLE 310 320 330 340 350 360 GSMGLRSLWG SLLASLTPPP LPPPDPPAPP TLLHNCHLCQ KLQRDSPTCH ACLHPNRTVP 370 380 390 400 410 TALSSPWYHT YGLAPPWPWS PVLLSLPQPQ QCSLFSVMEL ARLKSFVFPG

References

[1]	"Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics." Lai C.-H., Chou C.-Y., Ch'ang L.-Y., Liu C.-S., Lin W.-C. Genome Res. 10:703-713(2000) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANTS THR-262; PRO-292 AND PRO-383.
[2]	"Pediatric leukemia cDNA sequencing project." Zhou J., Yu W., Tang H., Mei G., Tsang Y.T.M., Bouck J., Gibbs R.A., Margolin J.F. Submitted (JUL-2000) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT PRO-383. Tissue: Leukemia.
[3]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANTS THR-262; PRO-292 AND PRO-383. Tissue: Cervix.
[4]	"Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)." Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B. Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANTS THR-262; PRO-292 AND PRO-383.
[5]	"Generation and annotation of the DNA sequences of human chromosomes 2 and 4." Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H. , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K. Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[6]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANTS THR-262; PRO-292 AND PRO-383. Tissue: Colon and Kidney.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF151815 mRNA. Translation: AAD34052.1. AY007160 mRNA. Translation: AAG02008.1. AF070638 mRNA. Translation: AAC25393.1. AK314975 mRNA. Translation: BAG37474.1. CR457401 mRNA. Translation: CAG33682.1. AC068946 Genomic DNA. No translation available. BC001393 mRNA. Translation: AAH01393.1. BC012821 mRNA. Translation: AAH12821.1.
IPI	IPI00107065.
RefSeq	NP_056495.3. NM_015680.4.
UniGene	Hs.4973.
3D structure databases
ProteinModelPortal	Q9BV87.
SMR	Q9BV87. Positions 47-183.
ModBase	Search...
PTM databases
PhosphoSite	Q9BV87.
Polymorphism databases
DMDM	296434422.
Proteomic databases
PaxDb	Q9BV87.
PRIDE	Q9BV87.
Protocols and materials databases
DNASU	27013.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000360507; ENSP00000353698; ENSG00000115649. ENST00000409789; ENSP00000386277; ENSG00000115649.
GeneID	27013.
KEGG	hsa:27013.
UCSC	uc002vju.4. human.
Organism-specific databases
CTD	27013.
GeneCards	GC02M220037.
HGNC	HGNC:25220. CNPPD1.
neXtProt	NX_Q9BV87.
PharmGKB	PA134874121.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG322958.
HOVERGEN	HBG054544.
InParanoid	Q9BV87.
OMA	YTYTDLC.
OrthoDB	EOG4JHCGF.
PhylomeDB	Q9BV87.
Gene expression databases
ArrayExpress	Q9BV87.
Bgee	Q9BV87.
CleanEx	HS_C2orf24.
Genevestigator	Q9BV87.
GermOnline	ENSG00000115649. Homo sapiens.
Family and domain databases
InterPro	IPR013922. Cyclin_PHO80-like. [Graphical view]
Pfam	PF08613. Cyclin. 1 hit. [Graphical view]
ProtoNet	Search...
Other
ChiTaRS	CNPPD1. human.
GenomeRNAi	27013.
NextBio	49528.

Entry information

Entry name

CNPD1_HUMAN

Accession

Primary (citable) accession number: Q9BV87
Secondary accession number(s): B2RC77 , O75548, Q9H4N0, Q9UQN0

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 5, 2005
Last sequence update:	May 18, 2010
Last modified:	May 1, 2013
This is version 87 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.