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Q9BV87 (CNPD1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 96. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (4) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Protein CNPPD1
Alternative name(s):
Cyclin Pas1/PHO80 domain-containing protein 1
Gene names
Name:CNPPD1
Synonyms:C2orf24
ORF Names:CDABP0125, CGI-57
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length410 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Subcellular location

Membrane; Single-pass membrane protein Potential.

Sequence similarities

Belongs to the CNPPD1 family.

Ontologies

Keywords
   Cellular componentMembrane
   Coding sequence diversityPolymorphism
   DomainTransmembrane
Transmembrane helix
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processregulation of cyclin-dependent protein serine/threonine kinase activity

Inferred from electronic annotation. Source: InterPro

   Cellular_componentintegral component of membrane

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 410410Protein CNPPD1
PRO_0000089352

Regions

Transmembrane233 – 25321Helical; Potential
Compositional bias318 – 38972Pro-rich

Natural variations

Natural variant2621I → T. Ref.1 Ref.3 Ref.4 Ref.6
Corresponds to variant rs1043160 [ dbSNP | Ensembl ].
VAR_022825
Natural variant2921L → P. Ref.1 Ref.3 Ref.4 Ref.6
Corresponds to variant rs1127102 [ dbSNP | Ensembl ].
VAR_024298
Natural variant3441R → T.
Corresponds to variant rs1043161 [ dbSNP | Ensembl ].
VAR_056769
Natural variant3661P → L.
Corresponds to variant rs17655123 [ dbSNP | Ensembl ].
VAR_024299
Natural variant3831L → P. Ref.1 Ref.2 Ref.3 Ref.4 Ref.6
Corresponds to variant rs4674361 [ dbSNP | Ensembl ].
VAR_024300

Experimental info

Sequence conflict381R → G in AAD34052. Ref.1

Sequences

Sequence LengthMass (Da)Tools
Q9BV87 [UniParc].

Last modified May 18, 2010. Version 2.
Checksum: 9C0C75F7BF026C6A

FASTA41045,456
        10         20         30         40         50         60 
MDLTGLLLDE EGTFSLAGFQ DFTFLPGHQK LSARIRRRLY YGWDWEADCS LEELSSPVAD 

        70         80         90        100        110        120 
IAVELLQKAA PSPIRRLQKK YVAHVSREAC ISPCAMMLAL VYIERLRHRN PDYLQHVSSS 

       130        140        150        160        170        180 
DLFLISMMVA SKYLYDEGEE EEVFNDEWGA AGGVAVPTLN ALERGFLSAM DWHLYTDPRE 

       190        200        210        220        230        240 
IFEVLSWLES CVAEQQGRWR GWYTYTDLCV LLEQPTWQLA LGSLCQRLVK LSCLLAVAYV 

       250        260        270        280        290        300 
SSVALAVASV AVIHQSLGLS CIPTPGPPDL GLTSRCLLEP CIPSVPQCLP SLANVSSCLE 

       310        320        330        340        350        360 
GSMGLRSLWG SLLASLTPPP LPPPDPPAPP TLLHNCHLCQ KLQRDSPTCH ACLHPNRTVP 

       370        380        390        400        410 
TALSSPWYHT YGLAPPWPWS PVLLSLPQPQ QCSLFSVMEL ARLKSFVFPG 

« Hide

References

[1]"Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics."
Lai C.-H., Chou C.-Y., Ch'ang L.-Y., Liu C.-S., Lin W.-C.
Genome Res. 10:703-713(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANTS THR-262; PRO-292 AND PRO-383.
[2]"Pediatric leukemia cDNA sequencing project."
Zhou J., Yu W., Tang H., Mei G., Tsang Y.T.M., Bouck J., Gibbs R.A., Margolin J.F.
Submitted (JUL-2000) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT PRO-383.
Tissue: Leukemia.
[3]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANTS THR-262; PRO-292 AND PRO-383.
Tissue: Cervix.
[4]"Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.
Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANTS THR-262; PRO-292 AND PRO-383.
[5]"Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H. expand/collapse author list , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[6]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANTS THR-262; PRO-292 AND PRO-383.
Tissue: Colon and Kidney.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF151815 mRNA. Translation: AAD34052.1.
AY007160 mRNA. Translation: AAG02008.1.
AF070638 mRNA. Translation: AAC25393.1.
AK314975 mRNA. Translation: BAG37474.1.
CR457401 mRNA. Translation: CAG33682.1.
AC068946 Genomic DNA. No translation available.
BC001393 mRNA. Translation: AAH01393.1.
BC012821 mRNA. Translation: AAH12821.1.
CCDSCCDS2433.1.
RefSeqNP_056495.3. NM_015680.4.
XP_005246519.1. XM_005246462.1.
XP_005246520.1. XM_005246463.2.
XP_006712482.1. XM_006712419.1.
UniGeneHs.4973.

3D structure databases

ProteinModelPortalQ9BV87.
SMRQ9BV87. Positions 48-232.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid117955. 1 interaction.

PTM databases

PhosphoSiteQ9BV87.

Polymorphism databases

DMDM296434422.

Proteomic databases

PaxDbQ9BV87.
PRIDEQ9BV87.

Protocols and materials databases

DNASU27013.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000360507; ENSP00000353698; ENSG00000115649.
ENST00000409789; ENSP00000386277; ENSG00000115649.
GeneID27013.
KEGGhsa:27013.
UCSCuc002vju.4. human.

Organism-specific databases

CTD27013.
GeneCardsGC02M220037.
HGNCHGNC:25220. CNPPD1.
HPAHPA049303.
neXtProtNX_Q9BV87.
PharmGKBPA134874121.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG322958.
HOVERGENHBG054544.
InParanoidQ9BV87.
OMARRRGWYT.
OrthoDBEOG7T4MKJ.
PhylomeDBQ9BV87.
TreeFamTF105853.

Gene expression databases

ArrayExpressQ9BV87.
BgeeQ9BV87.
CleanExHS_C2orf24.
GenevestigatorQ9BV87.

Family and domain databases

InterProIPR013922. Cyclin_PHO80-like.
[Graphical view]
PfamPF08613. Cyclin. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSCNPPD1. human.
GenomeRNAi27013.
NextBio49528.
PROQ9BV87.

Entry information

Entry nameCNPD1_HUMAN
AccessionPrimary (citable) accession number: Q9BV87
Secondary accession number(s): B2RC77 expand/collapse secondary AC list , O75548, Q9H4N0, Q9UQN0
Entry history
Integrated into UniProtKB/Swiss-Prot: July 5, 2005
Last sequence update: May 18, 2010
Last modified: July 9, 2014
This is version 96 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 2

Human chromosome 2: entries, gene names and cross-references to MIM