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Protein

ER membrane protein complex subunit 6

Gene

EMC6

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Biological processi

  • autophagosome assembly Source: UniProtKB
  • protein folding in endoplasmic reticulum Source: GO_Central

Protein family/group databases

TCDBi3.A.27.1.1 the c-terminal tail-anchored membrane protein biogenesis/ insertion complex-2 (tamp-b2) family

Names & Taxonomyi

Protein namesi
Recommended name:
ER membrane protein complex subunit 6
Alternative name(s):
Transmembrane protein 93
Gene namesi
Name:EMC6
Synonyms:TMEM93
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

EuPathDBiHostDB:ENSG00000127774.6
HGNCiHGNC:28430 EMC6
neXtProtiNX_Q9BV81

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei48 – 68HelicalSequence analysisAdd BLAST21
Transmembranei87 – 107HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi83460
OpenTargetsiENSG00000127774
PharmGKBiPA142670745

Polymorphism and mutation databases

DMDMi74733294

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources
ChainiPRO_00002541562 – 110ER membrane protein complex subunit 6Add BLAST109

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineCombined sources1

Keywords - PTMi

Acetylation

Proteomic databases

EPDiQ9BV81
MaxQBiQ9BV81
PaxDbiQ9BV81
PeptideAtlasiQ9BV81
PRIDEiQ9BV81
TopDownProteomicsiQ9BV81

PTM databases

iPTMnetiQ9BV81
PhosphoSitePlusiQ9BV81

Expressioni

Gene expression databases

BgeeiENSG00000127774
CleanExiHS_TMEM93
GenevisibleiQ9BV81 HS

Organism-specific databases

HPAiHPA062681

Interactioni

Subunit structurei

Component of the ER membrane protein complex (EMC).1 Publication

Protein-protein interaction databases

BioGridi12365612 interactors.
IntActiQ9BV81 4 interactors.
STRINGi9606.ENSP00000248378

Structurei

3D structure databases

ProteinModelPortaliQ9BV81
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the EMC6 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4455 Eukaryota
ENOG4111QZA LUCA
GeneTreeiENSGT00390000003917
HOGENOMiHOG000246672
HOVERGENiHBG094077
InParanoidiQ9BV81
OMAiFIYGMVH
OrthoDBiEOG091G173E
PhylomeDBiQ9BV81
TreeFamiTF332611

Family and domain databases

InterProiView protein in InterPro
IPR008504 Emc6
IPR029008 Rab5IP_fam
PANTHERiPTHR20994 PTHR20994, 1 hit
PfamiView protein in Pfam
PF07019 Rab5ip, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9BV81-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAVVAKREG PPFISEAAVR GNAAVLDYCR TSVSALSGAT AGILGLTGLY
60 70 80 90 100
GFIFYLLASV LLSLLLILKA GRRWNKYFKS RRPLFTGGLI GGLFTYVLFW
110
TFLYGMVHVY
Length:110
Mass (Da):12,017
Last modified:June 1, 2001 - v1
Checksum:i5120B6E4CC12FD48
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC001409 mRNA Translation: AAH01409.1
CCDSiCCDS11033.1
RefSeqiNP_001014764.1, NM_001014764.2
NP_112588.1, NM_031298.3
UniGeneiHs.30011

Genome annotation databases

EnsembliENST00000248378; ENSP00000248378; ENSG00000127774
ENST00000397133; ENSP00000380322; ENSG00000127774
GeneIDi83460
KEGGihsa:83460
UCSCiuc002fwf.3 human

Similar proteinsi

Entry informationi

Entry nameiEMC6_HUMAN
AccessioniPrimary (citable) accession number: Q9BV81
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 31, 2006
Last sequence update: June 1, 2001
Last modified: April 25, 2018
This is version 107 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome