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Protein

ER membrane protein complex subunit 6

Gene

EMC6

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

GO - Biological processi

  • autophagosome assembly Source: UniProtKB
  • protein folding in endoplasmic reticulum Source: GO_Central
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
ER membrane protein complex subunit 6
Alternative name(s):
Transmembrane protein 93
Gene namesi
Name:EMC6
Synonyms:TMEM93
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

HGNCiHGNC:28430. EMC6.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei48 – 6821HelicalSequence analysisAdd
BLAST
Transmembranei87 – 10721HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

  • ER membrane protein complex Source: UniProtKB
  • integral component of endoplasmic reticulum membrane Source: UniProtKB
  • integral component of membrane Source: UniProtKB
  • integral component of omegasome membrane Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA142670745.

Polymorphism and mutation databases

DMDMi74733294.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemovedCombined sources
Chaini2 – 110109ER membrane protein complex subunit 6PRO_0000254156Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylalanineCombined sources

Keywords - PTMi

Acetylation

Proteomic databases

EPDiQ9BV81.
MaxQBiQ9BV81.
PaxDbiQ9BV81.
PeptideAtlasiQ9BV81.
PRIDEiQ9BV81.
TopDownProteomicsiQ9BV81.

PTM databases

iPTMnetiQ9BV81.

Expressioni

Gene expression databases

BgeeiQ9BV81.
CleanExiHS_TMEM93.
GenevisibleiQ9BV81. HS.

Organism-specific databases

HPAiHPA062681.

Interactioni

Subunit structurei

Component of the ER membrane protein complex (EMC).1 Publication

Protein-protein interaction databases

BioGridi123656. 11 interactions.
IntActiQ9BV81. 4 interactions.
STRINGi9606.ENSP00000248378.

Structurei

3D structure databases

ProteinModelPortaliQ9BV81.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the EMC6 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4455. Eukaryota.
ENOG4111QZA. LUCA.
GeneTreeiENSGT00390000003917.
HOGENOMiHOG000246672.
HOVERGENiHBG094077.
InParanoidiQ9BV81.
OMAiGRRWNKC.
OrthoDBiEOG7NGQFK.
PhylomeDBiQ9BV81.
TreeFamiTF332611.

Family and domain databases

InterProiIPR008504. Emc6.
IPR029008. Rab5IP_fam.
[Graphical view]
PANTHERiPTHR20994. PTHR20994. 1 hit.
PfamiPF07019. Rab5ip. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9BV81-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAVVAKREG PPFISEAAVR GNAAVLDYCR TSVSALSGAT AGILGLTGLY
60 70 80 90 100
GFIFYLLASV LLSLLLILKA GRRWNKYFKS RRPLFTGGLI GGLFTYVLFW
110
TFLYGMVHVY
Length:110
Mass (Da):12,017
Last modified:June 1, 2001 - v1
Checksum:i5120B6E4CC12FD48
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC001409 mRNA. Translation: AAH01409.1.
CCDSiCCDS11033.1.
RefSeqiNP_001014764.1. NM_001014764.2.
NP_112588.1. NM_031298.3.
UniGeneiHs.30011.

Genome annotation databases

EnsembliENST00000248378; ENSP00000248378; ENSG00000127774.
ENST00000397133; ENSP00000380322; ENSG00000127774.
GeneIDi83460.
KEGGihsa:83460.
UCSCiuc002fwf.3. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC001409 mRNA. Translation: AAH01409.1.
CCDSiCCDS11033.1.
RefSeqiNP_001014764.1. NM_001014764.2.
NP_112588.1. NM_031298.3.
UniGeneiHs.30011.

3D structure databases

ProteinModelPortaliQ9BV81.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi123656. 11 interactions.
IntActiQ9BV81. 4 interactions.
STRINGi9606.ENSP00000248378.

PTM databases

iPTMnetiQ9BV81.

Polymorphism and mutation databases

DMDMi74733294.

Proteomic databases

EPDiQ9BV81.
MaxQBiQ9BV81.
PaxDbiQ9BV81.
PeptideAtlasiQ9BV81.
PRIDEiQ9BV81.
TopDownProteomicsiQ9BV81.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000248378; ENSP00000248378; ENSG00000127774.
ENST00000397133; ENSP00000380322; ENSG00000127774.
GeneIDi83460.
KEGGihsa:83460.
UCSCiuc002fwf.3. human.

Organism-specific databases

CTDi83460.
GeneCardsiEMC6.
HGNCiHGNC:28430. EMC6.
HPAiHPA062681.
neXtProtiNX_Q9BV81.
PharmGKBiPA142670745.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG4455. Eukaryota.
ENOG4111QZA. LUCA.
GeneTreeiENSGT00390000003917.
HOGENOMiHOG000246672.
HOVERGENiHBG094077.
InParanoidiQ9BV81.
OMAiGRRWNKC.
OrthoDBiEOG7NGQFK.
PhylomeDBiQ9BV81.
TreeFamiTF332611.

Miscellaneous databases

GenomeRNAii83460.
PROiQ9BV81.

Gene expression databases

BgeeiQ9BV81.
CleanExiHS_TMEM93.
GenevisibleiQ9BV81. HS.

Family and domain databases

InterProiIPR008504. Emc6.
IPR029008. Rab5IP_fam.
[Graphical view]
PANTHERiPTHR20994. PTHR20994. 1 hit.
PfamiPF07019. Rab5ip. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Placenta.
  2. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  3. Cited for: IDENTIFICATION IN THE EMC COMPLEX, SUBCELLULAR LOCATION.
  4. Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2, CLEAVAGE OF INITIATOR METHIONINE [LARGE SCALE ANALYSIS], IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiEMC6_HUMAN
AccessioniPrimary (citable) accession number: Q9BV81
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 31, 2006
Last sequence update: June 1, 2001
Last modified: July 6, 2016
This is version 97 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.