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Q9BV68

- RN126_HUMAN

UniProt

Q9BV68 - RN126_HUMAN

Protein

E3 ubiquitin-protein ligase RNF126

Gene

RNF126

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 108 (01 Oct 2014)
      Sequence version 1 (01 Jun 2001)
      Previous versions | rss
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    Functioni

    E3 ubiquitin-protein ligase. By ubiquitinating CDKN1A/p21 and targeting it for proteasomal degradation, may promote cell proliferation.1 Publication

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri229 – 27042RING-typePROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. ligase activity Source: UniProtKB-KW
    2. protein binding Source: IntAct
    3. zinc ion binding Source: InterPro

    Keywords - Molecular functioni

    Ligase

    Keywords - Biological processi

    Ubl conjugation pathway

    Keywords - Ligandi

    Metal-binding, Zinc

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    E3 ubiquitin-protein ligase RNF126 (EC:6.3.2.-)
    Alternative name(s):
    RING finger protein 126
    Gene namesi
    Name:RNF126
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 19

    Organism-specific databases

    HGNCiHGNC:21151. RNF126.

    Subcellular locationi

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell
    2. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm, Nucleus

    Pathology & Biotechi

    Mutagenesis

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Mutagenesisi229 – 2291C → A: Loss of E3 ligase activity; when associated with A-232. 1 Publication
    Mutagenesisi232 – 2321C → A: Loss of E3 ligase activity; when associated with A-229. 1 Publication

    Organism-specific databases

    PharmGKBiPA134876469.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11Removed1 Publication
    Chaini2 – 326325E3 ubiquitin-protein ligase RNF126PRO_0000056093Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei2 – 21N-acetylalanine1 Publication
    Modified residuei5 – 51Phosphoserine1 Publication

    Post-translational modificationi

    Auto-ubiquitinated.1 Publication

    Keywords - PTMi

    Acetylation, Phosphoprotein, Ubl conjugation

    Proteomic databases

    MaxQBiQ9BV68.
    PaxDbiQ9BV68.
    PRIDEiQ9BV68.

    PTM databases

    PhosphoSiteiQ9BV68.

    Expressioni

    Tissue specificityi

    Highly expressed in liver and testis.1 Publication

    Gene expression databases

    ArrayExpressiQ9BV68.
    BgeeiQ9BV68.
    CleanExiHS_RNF126.
    GenevestigatoriQ9BV68.

    Organism-specific databases

    HPAiHPA043050.

    Interactioni

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    UBE2D1P516683EBI-357322,EBI-743540
    UBE2D3P610773EBI-357322,EBI-348268
    UBE2D4Q9Y2X83EBI-357322,EBI-745527

    Protein-protein interaction databases

    BioGridi120790. 35 interactions.
    IntActiQ9BV68. 20 interactions.
    MINTiMINT-1032305.
    STRINGi9606.ENSP00000292363.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9BV68.
    SMRiQ9BV68. Positions 219-288.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi289 – 30315Ser-richAdd
    BLAST

    Sequence similaritiesi

    Contains 1 RING-type zinc finger.PROSITE-ProRule annotation

    Zinc finger

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri229 – 27042RING-typePROSITE-ProRule annotationAdd
    BLAST

    Keywords - Domaini

    Zinc-finger

    Phylogenomic databases

    eggNOGiCOG5540.
    HOGENOMiHOG000116417.
    HOVERGENiHBG059832.
    InParanoidiQ9BV68.
    KOiK11982.
    OMAiLEHVDQH.
    OrthoDBiEOG7353XB.
    PhylomeDBiQ9BV68.
    TreeFamiTF317985.

    Family and domain databases

    Gene3Di3.30.40.10. 1 hit.
    InterProiIPR001841. Znf_RING.
    IPR013083. Znf_RING/FYVE/PHD.
    [Graphical view]
    PfamiPF13639. zf-RING_2. 1 hit.
    [Graphical view]
    SMARTiSM00184. RING. 1 hit.
    [Graphical view]
    PROSITEiPS50089. ZF_RING_2. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q9BV68-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MAEASPHPGR YFCHCCSVEI VPRLPDYICP RCESGFIEEL PEETRSTENG    50
    SAPSTAPTDQ SRPPLEHVDQ HLFTLPQGYG QFAFGIFDDS FEIPTFPPGA 100
    QADDGRDPES RRERDHPSRH RYGARQPRAR LTTRRATGRH EGVPTLEGII 150
    QQLVNGIITP ATIPSLGPWG VLHSNPMDYA WGANGLDAII TQLLNQFENT 200
    GPPPADKEKI QALPTVPVTE EHVGSGLECP VCKDDYALGE RVRQLPCNHL 250
    FHDGCIVPWL EQHDSCPVCR KSLTGQNTAT NPPGLTGVSF SSSSSSSSSS 300
    SPSNENATWS PLGRPQPPRP LSNLTL 326
    Length:326
    Mass (Da):35,585
    Last modified:June 1, 2001 - v1
    Checksum:iD422FFB090362F46
    GO
    Isoform 2 (identifier: Q9BV68-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         309-311: WSP → SNS
         312-326: Missing.

    Show »
    Length:311
    Mass (Da):33,861
    Checksum:i0C748E78E6719C3E
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti68 – 681V → M.
    Corresponds to variant rs2285751 [ dbSNP | Ensembl ].
    VAR_057217

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei309 – 3113WSP → SNS in isoform 2. 2 PublicationsVSP_015693
    Alternative sequencei312 – 32615Missing in isoform 2. 2 PublicationsVSP_015694Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK000559 mRNA. Translation: BAA91254.1.
    BC001442 mRNA. Translation: AAH01442.1.
    BC025374 mRNA. Translation: AAH25374.1.
    CCDSiCCDS12039.1. [Q9BV68-2]
    RefSeqiNP_919442.1. NM_194460.2. [Q9BV68-2]
    UniGeneiHs.69554.

    Genome annotation databases

    EnsembliENST00000292363; ENSP00000292363; ENSG00000070423. [Q9BV68-2]
    GeneIDi55658.
    KEGGihsa:55658.
    UCSCiuc010drs.3. human. [Q9BV68-2]

    Polymorphism databases

    DMDMi74762712.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK000559 mRNA. Translation: BAA91254.1 .
    BC001442 mRNA. Translation: AAH01442.1 .
    BC025374 mRNA. Translation: AAH25374.1 .
    CCDSi CCDS12039.1. [Q9BV68-2 ]
    RefSeqi NP_919442.1. NM_194460.2. [Q9BV68-2 ]
    UniGenei Hs.69554.

    3D structure databases

    ProteinModelPortali Q9BV68.
    SMRi Q9BV68. Positions 219-288.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 120790. 35 interactions.
    IntActi Q9BV68. 20 interactions.
    MINTi MINT-1032305.
    STRINGi 9606.ENSP00000292363.

    PTM databases

    PhosphoSitei Q9BV68.

    Polymorphism databases

    DMDMi 74762712.

    Proteomic databases

    MaxQBi Q9BV68.
    PaxDbi Q9BV68.
    PRIDEi Q9BV68.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000292363 ; ENSP00000292363 ; ENSG00000070423 . [Q9BV68-2 ]
    GeneIDi 55658.
    KEGGi hsa:55658.
    UCSCi uc010drs.3. human. [Q9BV68-2 ]

    Organism-specific databases

    CTDi 55658.
    GeneCardsi GC19M000647.
    H-InvDB HIX0014558.
    HGNCi HGNC:21151. RNF126.
    HPAi HPA043050.
    MIMi 615177. gene.
    neXtProti NX_Q9BV68.
    PharmGKBi PA134876469.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG5540.
    HOGENOMi HOG000116417.
    HOVERGENi HBG059832.
    InParanoidi Q9BV68.
    KOi K11982.
    OMAi LEHVDQH.
    OrthoDBi EOG7353XB.
    PhylomeDBi Q9BV68.
    TreeFami TF317985.

    Miscellaneous databases

    ChiTaRSi RNF126. human.
    GenomeRNAii 55658.
    NextBioi 60383.
    PROi Q9BV68.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q9BV68.
    Bgeei Q9BV68.
    CleanExi HS_RNF126.
    Genevestigatori Q9BV68.

    Family and domain databases

    Gene3Di 3.30.40.10. 1 hit.
    InterProi IPR001841. Znf_RING.
    IPR013083. Znf_RING/FYVE/PHD.
    [Graphical view ]
    Pfami PF13639. zf-RING_2. 1 hit.
    [Graphical view ]
    SMARTi SM00184. RING. 1 hit.
    [Graphical view ]
    PROSITEi PS50089. ZF_RING_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
      Tissue: Brain and Placenta.
    3. "Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."
      Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R., Greff Z., Keri G., Stemmann O., Mann M.
      Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    4. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
      Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
      Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2, PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-5, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS], CLEAVAGE OF INITIATOR METHIONINE [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    5. "E3 ubiquitin ligase RNF126 promotes cancer cell proliferation by targeting the tumor suppressor p21 for ubiquitin-mediated degradation."
      Zhi X., Zhao D., Wang Z., Zhou Z., Wang C., Chen W., Liu R., Chen C.
      Cancer Res. 73:385-394(2013) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, AUTOUBIQUITINATION, TISSUE SPECIFICITY, MUTAGENESIS OF CYS-229 AND CYS-232.

    Entry informationi

    Entry nameiRN126_HUMAN
    AccessioniPrimary (citable) accession number: Q9BV68
    Secondary accession number(s): Q9NWX1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 27, 2005
    Last sequence update: June 1, 2001
    Last modified: October 1, 2014
    This is version 108 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 19
      Human chromosome 19: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3