Q9BV47D3DSV8Q9BTW0DUS26_HUMANDual specificity protein phosphatase 263.1.3.163.1.3.48Dual specificity phosphatase SKRP3Low-molecular-mass dual-specificity phosphatase 4DSP-4LDP-4Mitogen-activated protein kinase phosphatase 8MAP kinase phosphatase 8MKP-8Novel amplified gene in thyroid anaplastic cancerDUSP26DUSP24LDP4MKP8NATA1SKRP3Homo sapiensHumanEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomoMKP-8, a novel MAPK phosphatase that inhibits p38 kinase.NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)MUTAGENESIS OF CYS-152FUNCTIONSUBCELLULAR LOCATIONTISSUE SPECIFICITYA novel amplification target, DUSP26, promotes anaplastic thyroid cancer cell growth by inhibiting p38 MAPK activity.NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)MUTAGENESIS OF CYS-152FUNCTIONTISSUE SPECIFICITYCharacterization of a novel low-molecular-mass dual specificity phosphatase-4 (LDP-4) expressed in brain.NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)FUNCTIONSUBCELLULAR LOCATIONTISSUE SPECIFICITYIdentification of a novel dual specificity phosphatase, SKRP3.NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)Complete sequencing and characterization of 21,243 full-length human cDNAs.NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2)Association and regulation of heat shock transcription factor 4b with both extracellular signal-regulated kinase mitogen-activated protein kinase and dual-specificity tyrosine phosphatase DUSP26.FUNCTIONMUTAGENESIS OF CYS-152INTERACTION WITH HSF4TISSUE SPECIFICITYInactivates MAPK1 and MAPK3 which leads to dephosphorylation of heat shock factor protein 4 and a reduction in its DNA-binding activity. Inhibits MAP kinase p38 by dephosphorylating it and inhibits p38-mediated apoptosis in anaplastic thyroid cancer cells. Can also induce activation of MAP kinase p38 and c-Jun N-terminal kinase (JNK).H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphateH2O + O-phospho-L-seryl-[protein] = L-seryl-[protein] + phosphateH2O + O-phospho-L-threonyl-[protein] = L-threonyl-[protein] + phosphateInteracts with HSF4.Q9BV47Q13137false3Q9BV47Q9BWT7false3Q9BV47A6NEM1false3Q9BV47Q4V328false3Q9BV47Q7Z3Y8false3Q9BV47P04637false9CytoplasmNucleusGolgi apparatusQ9BV47-11Q9BV47-22Brain. In the brain it is expressed ubiquitously except in the hippocampus. Expressed in embryonal cancers (retinoblastoma, neuroepithilioma and neuroblastoma) and in anaplatic thyroid cancer.Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.3D-structureAlternative splicingCytoplasmGolgi apparatusHydrolaseNucleusProtein phosphataseReference proteomeCASMCPGNWLWASMTFMARFSRSSSRSPVRTRGTLEEMPTVQHPFLNVFELERLLYTGKTACNHADEVWPGLYLGDQDMANNRRELRRLGITHVLNASHSRWRGTPEAYEGLGIRYLGVEAHDSPAFDMSIHFQTAADFIHRALSQPGGKILVHCAVGVSRSATLVLAYLMLYHHLTLVEAIKKVKDHRGIIPNRGFLRQLLALDRRLRQGLEA
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