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Q9BV47

- DUS26_HUMAN

UniProt

Q9BV47 - DUS26_HUMAN

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Protein

Dual specificity protein phosphatase 26

Gene

DUSP26

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Inactivates MAPK1 and MAPK3 which leads to dephosphorylation of heat shock factor protein 4 and a reduction in its DNA-binding activity. Inhibits MAP kinase p38 by dephosphorylating it and inhibits p38-mediated apoptosis in anaplastic thyroid cancer cells. Can also induce activation of MAP kinase p38 and c-Jun N-terminal kinase (JNK).4 Publications

Catalytic activityi

Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.PROSITE-ProRule annotation
[a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei152 – 1521Phosphocysteine intermediatePROSITE-ProRule annotation

GO - Molecular functioni

  1. p53 binding Source: UniProt
  2. phosphoprotein phosphatase activity Source: UniProt
  3. phosphoserine phosphatase activity Source: UniProt
  4. protein tyrosine/serine/threonine phosphatase activity Source: RefGenome
  5. protein tyrosine phosphatase activity Source: UniProt
  6. RNA polymerase II activating transcription factor binding Source: UniProt

GO - Biological processi

  1. negative regulation of ERK1 and ERK2 cascade Source: UniProt
  2. negative regulation of protein kinase activity by regulation of protein phosphorylation Source: UniProt
  3. negative regulation of transcription from RNA polymerase II promoter Source: UniProt
  4. peptidyl-tyrosine dephosphorylation Source: GOC
  5. positive regulation of cell adhesion Source: UniProt
  6. positive regulation of peptidyl-serine dephosphorylation Source: UniProt
  7. protein dephosphorylation Source: UniProt
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protein phosphatase

Names & Taxonomyi

Protein namesi
Recommended name:
Dual specificity protein phosphatase 26 (EC:3.1.3.16, EC:3.1.3.48)
Alternative name(s):
Dual specificity phosphatase SKRP3
Low-molecular-mass dual-specificity phosphatase 4
Short name:
DSP-4
Short name:
LDP-4
Mitogen-activated protein kinase phosphatase 8
Short name:
MAP kinase phosphatase 8
Short name:
MKP-8
Novel amplified gene in thyroid anaplastic cancer
Gene namesi
Name:DUSP26
Synonyms:DUSP24, LDP4, MKP8, NATA1, SKRP3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 8

Organism-specific databases

HGNCiHGNC:28161. DUSP26.

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: UniProt
  2. extracellular vesicular exosome Source: UniProt
  3. Golgi apparatus Source: UniProt
  4. mitochondrion Source: Ensembl
  5. nucleus Source: UniProt
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Golgi apparatus, Nucleus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi152 – 1521C → A or S: Loss of activity. 3 Publications

Organism-specific databases

PharmGKBiPA142671921.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 211211Dual specificity protein phosphatase 26PRO_0000292219Add
BLAST

Proteomic databases

PaxDbiQ9BV47.
PRIDEiQ9BV47.

Expressioni

Tissue specificityi

Brain. In the brain it is expressed ubiquitously except in the hippocampus. Expressed in embryonal cancers (retinoblastoma, neuroepithilioma and neuroblastoma) and in anaplatic thyroid cancer.4 Publications

Gene expression databases

BgeeiQ9BV47.
CleanExiHS_DUSP26.
ExpressionAtlasiQ9BV47. baseline and differential.
GenevestigatoriQ9BV47.

Organism-specific databases

HPAiHPA018221.

Interactioni

Subunit structurei

Interacts with HSF4.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
TP53P046379EBI-2924519,EBI-366083

Protein-protein interaction databases

BioGridi122457. 1 interaction.
IntActiQ9BV47. 1 interaction.
STRINGi9606.ENSP00000256261.

Structurei

Secondary structure

1
211
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi62 – 665
Beta strandi69 – 724
Helixi74 – 774
Helixi80 – 867
Beta strandi90 – 934
Turni98 – 1003
Helixi106 – 1094
Beta strandi112 – 1154
Helixi127 – 14216
Beta strandi148 – 1514
Beta strandi153 – 1564
Helixi157 – 17014
Helixi175 – 18410
Helixi192 – 20716

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2E0TX-ray1.67A61-211[»]
4B04X-ray2.20A/B/C/D61-211[»]
4HRFX-ray1.68A/B/C/D61-211[»]
ProteinModelPortaliQ9BV47.
SMRiQ9BV47. Positions 31-210.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9BV47.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini61 – 206146Tyrosine-protein phosphataseAdd
BLAST

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG2453.
GeneTreeiENSGT00760000118853.
HOGENOMiHOG000233767.
HOVERGENiHBG001524.
InParanoidiQ9BV47.
KOiK14165.
OMAiMAFMSRF.
OrthoDBiEOG7CZK7N.
PhylomeDBiQ9BV47.
TreeFamiTF105128.

Family and domain databases

Gene3Di3.90.190.10. 1 hit.
InterProiIPR020417. Atypical_DUSP.
IPR020405. Atypical_DUSP_famA.
IPR000340. Dual-sp_phosphatase_cat-dom.
IPR020422. Dual-sp_phosphatase_subgr_cat.
IPR024950. DUSP.
IPR029021. Prot-tyrosine_phosphatase-like.
IPR000387. Tyr/Dual-sp_Pase.
IPR016130. Tyr_Pase_AS.
[Graphical view]
PANTHERiPTHR10159. PTHR10159. 1 hit.
PfamiPF00782. DSPc. 1 hit.
[Graphical view]
PRINTSiPR01908. ADSPHPHTASE.
PR01909. ADSPHPHTASEA.
SMARTiSM00195. DSPc. 1 hit.
[Graphical view]
SUPFAMiSSF52799. SSF52799. 1 hit.
PROSITEiPS00383. TYR_PHOSPHATASE_1. 1 hit.
PS50056. TYR_PHOSPHATASE_2. 1 hit.
PS50054. TYR_PHOSPHATASE_DUAL. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q9BV47-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MCPGNWLWAS MTFMARFSRS SSRSPVRTRG TLEEMPTVQH PFLNVFELER
60 70 80 90 100
LLYTGKTACN HADEVWPGLY LGDQDMANNR RELRRLGITH VLNASHSRWR
110 120 130 140 150
GTPEAYEGLG IRYLGVEAHD SPAFDMSIHF QTAADFIHRA LSQPGGKILV
160 170 180 190 200
HCAVGVSRSA TLVLAYLMLY HHLTLVEAIK KVKDHRGIIP NRGFLRQLLA
210
LDRRLRQGLE A
Length:211
Mass (Da):23,946
Last modified:June 1, 2001 - v1
Checksum:i60E944304905086D
GO
Isoform 2 (identifier: Q9BV47-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-125: Missing.

Show »
Length:86
Mass (Da):9,652
Checksum:i4DD29AFD5989528B
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 125125Missing in isoform 2. 1 PublicationVSP_026406Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY902194 mRNA. Translation: AAX07132.1.
AB158288 mRNA. Translation: BAD82942.1.
AB237597 mRNA. Translation: BAE46506.1.
AB103376 mRNA. Translation: BAD91015.1.
AK055704 mRNA. Translation: BAB70991.1.
CH471080 Genomic DNA. Translation: EAW63392.1.
CH471080 Genomic DNA. Translation: EAW63393.1.
CH471080 Genomic DNA. Translation: EAW63394.1.
BC001613 mRNA. Translation: AAH01613.1.
BC003115 mRNA. Translation: AAH03115.1.
BC067804 mRNA. Translation: AAH67804.1.
CCDSiCCDS6092.1. [Q9BV47-1]
RefSeqiNP_076930.1. NM_024025.1. [Q9BV47-1]
XP_005273690.1. XM_005273633.1. [Q9BV47-1]
XP_006716458.1. XM_006716395.1. [Q9BV47-1]
UniGeneiHs.8719.

Genome annotation databases

EnsembliENST00000256261; ENSP00000256261; ENSG00000133878. [Q9BV47-1]
ENST00000523956; ENSP00000429176; ENSG00000133878. [Q9BV47-1]
GeneIDi78986.
KEGGihsa:78986.
UCSCiuc003xjp.3. human. [Q9BV47-1]

Polymorphism databases

DMDMi74752374.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY902194 mRNA. Translation: AAX07132.1 .
AB158288 mRNA. Translation: BAD82942.1 .
AB237597 mRNA. Translation: BAE46506.1 .
AB103376 mRNA. Translation: BAD91015.1 .
AK055704 mRNA. Translation: BAB70991.1 .
CH471080 Genomic DNA. Translation: EAW63392.1 .
CH471080 Genomic DNA. Translation: EAW63393.1 .
CH471080 Genomic DNA. Translation: EAW63394.1 .
BC001613 mRNA. Translation: AAH01613.1 .
BC003115 mRNA. Translation: AAH03115.1 .
BC067804 mRNA. Translation: AAH67804.1 .
CCDSi CCDS6092.1. [Q9BV47-1 ]
RefSeqi NP_076930.1. NM_024025.1. [Q9BV47-1 ]
XP_005273690.1. XM_005273633.1. [Q9BV47-1 ]
XP_006716458.1. XM_006716395.1. [Q9BV47-1 ]
UniGenei Hs.8719.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
2E0T X-ray 1.67 A 61-211 [» ]
4B04 X-ray 2.20 A/B/C/D 61-211 [» ]
4HRF X-ray 1.68 A/B/C/D 61-211 [» ]
ProteinModelPortali Q9BV47.
SMRi Q9BV47. Positions 31-210.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 122457. 1 interaction.
IntActi Q9BV47. 1 interaction.
STRINGi 9606.ENSP00000256261.

Chemistry

ChEMBLi CHEMBL2295562.

Polymorphism databases

DMDMi 74752374.

Proteomic databases

PaxDbi Q9BV47.
PRIDEi Q9BV47.

Protocols and materials databases

DNASUi 78986.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000256261 ; ENSP00000256261 ; ENSG00000133878 . [Q9BV47-1 ]
ENST00000523956 ; ENSP00000429176 ; ENSG00000133878 . [Q9BV47-1 ]
GeneIDi 78986.
KEGGi hsa:78986.
UCSCi uc003xjp.3. human. [Q9BV47-1 ]

Organism-specific databases

CTDi 78986.
GeneCardsi GC08M033448.
HGNCi HGNC:28161. DUSP26.
HPAi HPA018221.
neXtProti NX_Q9BV47.
PharmGKBi PA142671921.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG2453.
GeneTreei ENSGT00760000118853.
HOGENOMi HOG000233767.
HOVERGENi HBG001524.
InParanoidi Q9BV47.
KOi K14165.
OMAi MAFMSRF.
OrthoDBi EOG7CZK7N.
PhylomeDBi Q9BV47.
TreeFami TF105128.

Miscellaneous databases

EvolutionaryTracei Q9BV47.
GenomeRNAii 78986.
NextBioi 67552.
PROi Q9BV47.

Gene expression databases

Bgeei Q9BV47.
CleanExi HS_DUSP26.
ExpressionAtlasi Q9BV47. baseline and differential.
Genevestigatori Q9BV47.

Family and domain databases

Gene3Di 3.90.190.10. 1 hit.
InterProi IPR020417. Atypical_DUSP.
IPR020405. Atypical_DUSP_famA.
IPR000340. Dual-sp_phosphatase_cat-dom.
IPR020422. Dual-sp_phosphatase_subgr_cat.
IPR024950. DUSP.
IPR029021. Prot-tyrosine_phosphatase-like.
IPR000387. Tyr/Dual-sp_Pase.
IPR016130. Tyr_Pase_AS.
[Graphical view ]
PANTHERi PTHR10159. PTHR10159. 1 hit.
Pfami PF00782. DSPc. 1 hit.
[Graphical view ]
PRINTSi PR01908. ADSPHPHTASE.
PR01909. ADSPHPHTASEA.
SMARTi SM00195. DSPc. 1 hit.
[Graphical view ]
SUPFAMi SSF52799. SSF52799. 1 hit.
PROSITEi PS00383. TYR_PHOSPHATASE_1. 1 hit.
PS50056. TYR_PHOSPHATASE_2. 1 hit.
PS50054. TYR_PHOSPHATASE_DUAL. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), MUTAGENESIS OF CYS-152, FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
  2. "A novel amplification target, DUSP26, promotes anaplastic thyroid cancer cell growth by inhibiting p38 MAPK activity."
    Yu W., Imoto I., Inoue J., Onda M., Emi M., Inazawa J.
    Oncogene 26:1178-1187(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), MUTAGENESIS OF CYS-152, FUNCTION, TISSUE SPECIFICITY.
  3. "Characterization of a novel low-molecular-mass dual specificity phosphatase-4 (LDP-4) expressed in brain."
    Takagaki K., Shima H., Tanuma N., Nomura M., Satoh T., Watanabe M., Kikuchi K.
    Mol. Cell. Biochem. 296:177-184(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
  4. "Identification of a novel dual specificity phosphatase, SKRP3."
    Zama T., Aoki R., Murata M., Ikeda Y.
    Submitted (FEB-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
  5. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
  6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
    Tissue: Brain and Lung.
  8. "Association and regulation of heat shock transcription factor 4b with both extracellular signal-regulated kinase mitogen-activated protein kinase and dual-specificity tyrosine phosphatase DUSP26."
    Hu Y., Mivechi N.F.
    Mol. Cell. Biol. 26:3282-3294(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, MUTAGENESIS OF CYS-152, INTERACTION WITH HSF4, TISSUE SPECIFICITY.

Entry informationi

Entry nameiDUS26_HUMAN
AccessioniPrimary (citable) accession number: Q9BV47
Secondary accession number(s): D3DSV8, Q9BTW0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 26, 2007
Last sequence update: June 1, 2001
Last modified: October 29, 2014
This is version 111 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 8
    Human chromosome 8: entries, gene names and cross-references to MIM
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3