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Protein

Dual specificity protein phosphatase 26

Gene

DUSP26

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Inactivates MAPK1 and MAPK3 which leads to dephosphorylation of heat shock factor protein 4 and a reduction in its DNA-binding activity. Inhibits MAP kinase p38 by dephosphorylating it and inhibits p38-mediated apoptosis in anaplastic thyroid cancer cells. Can also induce activation of MAP kinase p38 and c-Jun N-terminal kinase (JNK).4 Publications

Catalytic activityi

Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.PROSITE-ProRule annotation
[a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei152Phosphocysteine intermediatePROSITE-ProRule annotation1

GO - Molecular functioni

  • p53 binding Source: UniProtKB
  • phosphoprotein phosphatase activity Source: UniProtKB
  • phosphoserine phosphatase activity Source: UniProtKB
  • protein tyrosine/serine/threonine phosphatase activity Source: InterPro
  • protein tyrosine phosphatase activity Source: UniProtKB
  • RNA polymerase II activating transcription factor binding Source: UniProtKB

GO - Biological processi

  • negative regulation of ERK1 and ERK2 cascade Source: UniProtKB
  • negative regulation of protein kinase activity by regulation of protein phosphorylation Source: UniProtKB
  • negative regulation of transcription from RNA polymerase II promoter Source: UniProtKB
  • positive regulation of cell adhesion Source: UniProtKB
  • positive regulation of peptidyl-serine dephosphorylation Source: UniProtKB
  • protein dephosphorylation Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protein phosphatase

Enzyme and pathway databases

BioCyciZFISH:HS05793-MONOMER.
BRENDAi3.1.3.16. 2681.
SIGNORiQ9BV47.

Names & Taxonomyi

Protein namesi
Recommended name:
Dual specificity protein phosphatase 26 (EC:3.1.3.16, EC:3.1.3.48)
Alternative name(s):
Dual specificity phosphatase SKRP3
Low-molecular-mass dual-specificity phosphatase 4
Short name:
DSP-4
Short name:
LDP-4
Mitogen-activated protein kinase phosphatase 8
Short name:
MAP kinase phosphatase 8
Short name:
MKP-8
Novel amplified gene in thyroid anaplastic cancer
Gene namesi
Name:DUSP26
Synonyms:DUSP24, LDP4, MKP8, NATA1, SKRP3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 8

Organism-specific databases

HGNCiHGNC:28161. DUSP26.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: UniProtKB
  • extracellular exosome Source: UniProtKB
  • Golgi apparatus Source: UniProtKB
  • mitochondrion Source: Ensembl
  • nucleus Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Golgi apparatus, Nucleus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi152C → A or S: Loss of activity. 3 Publications1

Organism-specific databases

DisGeNETi78986.
OpenTargetsiENSG00000133878.
PharmGKBiPA142671921.

Chemistry databases

ChEMBLiCHEMBL2295562.

Polymorphism and mutation databases

BioMutaiDUSP26.
DMDMi74752374.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002922191 – 211Dual specificity protein phosphatase 26Add BLAST211

Proteomic databases

PaxDbiQ9BV47.
PeptideAtlasiQ9BV47.
PRIDEiQ9BV47.

PTM databases

DEPODiQ9BV47.
iPTMnetiQ9BV47.
PhosphoSitePlusiQ9BV47.

Expressioni

Tissue specificityi

Brain. In the brain it is expressed ubiquitously except in the hippocampus. Expressed in embryonal cancers (retinoblastoma, neuroepithilioma and neuroblastoma) and in anaplatic thyroid cancer.4 Publications

Gene expression databases

BgeeiENSG00000133878.
CleanExiHS_DUSP26.
ExpressionAtlasiQ9BV47. baseline and differential.
GenevisibleiQ9BV47. HS.

Organism-specific databases

HPAiHPA018221.

Interactioni

Subunit structurei

Interacts with HSF4.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
CALCOCO2Q131373EBI-2924519,EBI-739580
TP53P046379EBI-2924519,EBI-366083

GO - Molecular functioni

  • p53 binding Source: UniProtKB
  • RNA polymerase II activating transcription factor binding Source: UniProtKB

Protein-protein interaction databases

BioGridi122457. 2 interactors.
IntActiQ9BV47. 6 interactors.
STRINGi9606.ENSP00000256261.

Structurei

Secondary structure

1211
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi45 – 54Combined sources10
Beta strandi62 – 66Combined sources5
Beta strandi69 – 72Combined sources4
Helixi74 – 77Combined sources4
Helixi80 – 86Combined sources7
Beta strandi90 – 93Combined sources4
Turni98 – 100Combined sources3
Helixi106 – 109Combined sources4
Beta strandi112 – 115Combined sources4
Helixi127 – 142Combined sources16
Beta strandi148 – 151Combined sources4
Beta strandi153 – 156Combined sources4
Helixi157 – 170Combined sources14
Helixi175 – 184Combined sources10
Helixi192 – 207Combined sources16

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2E0TX-ray1.67A61-211[»]
4B04X-ray2.20A/B/C/D61-211[»]
4HRFX-ray1.68A/B/C/D61-211[»]
5GTJX-ray2.00A/B/C/D39-211[»]
ProteinModelPortaliQ9BV47.
SMRiQ9BV47.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9BV47.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini61 – 206Tyrosine-protein phosphataseAdd BLAST146

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG1716. Eukaryota.
COG2453. LUCA.
GeneTreeiENSGT00760000118853.
HOGENOMiHOG000233767.
HOVERGENiHBG001524.
InParanoidiQ9BV47.
KOiK14165.
OMAiYLMIRQN.
OrthoDBiEOG091G0249.
PhylomeDBiQ9BV47.
TreeFamiTF105128.

Family and domain databases

CDDicd00127. DSPc. 1 hit.
Gene3Di3.90.190.10. 1 hit.
InterProiIPR020417. Atypical_DUSP.
IPR020405. Atypical_DUSP_famA.
IPR000340. Dual-sp_phosphatase_cat-dom.
IPR024950. DUSP.
IPR029021. Prot-tyrosine_phosphatase-like.
IPR016130. Tyr_Pase_AS.
IPR000387. TYR_PHOSPHATASE_dom.
IPR020422. TYR_PHOSPHATASE_DUAL_dom.
[Graphical view]
PANTHERiPTHR10159. PTHR10159. 1 hit.
PfamiPF00782. DSPc. 1 hit.
[Graphical view]
PRINTSiPR01908. ADSPHPHTASE.
PR01909. ADSPHPHTASEA.
SMARTiSM00195. DSPc. 1 hit.
[Graphical view]
SUPFAMiSSF52799. SSF52799. 1 hit.
PROSITEiPS00383. TYR_PHOSPHATASE_1. 1 hit.
PS50056. TYR_PHOSPHATASE_2. 1 hit.
PS50054. TYR_PHOSPHATASE_DUAL. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9BV47-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MCPGNWLWAS MTFMARFSRS SSRSPVRTRG TLEEMPTVQH PFLNVFELER
60 70 80 90 100
LLYTGKTACN HADEVWPGLY LGDQDMANNR RELRRLGITH VLNASHSRWR
110 120 130 140 150
GTPEAYEGLG IRYLGVEAHD SPAFDMSIHF QTAADFIHRA LSQPGGKILV
160 170 180 190 200
HCAVGVSRSA TLVLAYLMLY HHLTLVEAIK KVKDHRGIIP NRGFLRQLLA
210
LDRRLRQGLE A
Length:211
Mass (Da):23,946
Last modified:June 1, 2001 - v1
Checksum:i60E944304905086D
GO
Isoform 2 (identifier: Q9BV47-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-125: Missing.

Show »
Length:86
Mass (Da):9,652
Checksum:i4DD29AFD5989528B
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0264061 – 125Missing in isoform 2. 1 PublicationAdd BLAST125

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY902194 mRNA. Translation: AAX07132.1.
AB158288 mRNA. Translation: BAD82942.1.
AB237597 mRNA. Translation: BAE46506.1.
AB103376 mRNA. Translation: BAD91015.1.
AK055704 mRNA. Translation: BAB70991.1.
CH471080 Genomic DNA. Translation: EAW63392.1.
CH471080 Genomic DNA. Translation: EAW63393.1.
CH471080 Genomic DNA. Translation: EAW63394.1.
BC001613 mRNA. Translation: AAH01613.1.
BC003115 mRNA. Translation: AAH03115.1.
BC067804 mRNA. Translation: AAH67804.1.
CCDSiCCDS6092.1. [Q9BV47-1]
RefSeqiNP_001292044.1. NM_001305115.1. [Q9BV47-1]
NP_001292045.1. NM_001305116.1. [Q9BV47-1]
NP_076930.1. NM_024025.2. [Q9BV47-1]
UniGeneiHs.8719.

Genome annotation databases

EnsembliENST00000256261; ENSP00000256261; ENSG00000133878. [Q9BV47-1]
ENST00000523956; ENSP00000429176; ENSG00000133878. [Q9BV47-1]
GeneIDi78986.
KEGGihsa:78986.
UCSCiuc003xjp.4. human. [Q9BV47-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY902194 mRNA. Translation: AAX07132.1.
AB158288 mRNA. Translation: BAD82942.1.
AB237597 mRNA. Translation: BAE46506.1.
AB103376 mRNA. Translation: BAD91015.1.
AK055704 mRNA. Translation: BAB70991.1.
CH471080 Genomic DNA. Translation: EAW63392.1.
CH471080 Genomic DNA. Translation: EAW63393.1.
CH471080 Genomic DNA. Translation: EAW63394.1.
BC001613 mRNA. Translation: AAH01613.1.
BC003115 mRNA. Translation: AAH03115.1.
BC067804 mRNA. Translation: AAH67804.1.
CCDSiCCDS6092.1. [Q9BV47-1]
RefSeqiNP_001292044.1. NM_001305115.1. [Q9BV47-1]
NP_001292045.1. NM_001305116.1. [Q9BV47-1]
NP_076930.1. NM_024025.2. [Q9BV47-1]
UniGeneiHs.8719.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2E0TX-ray1.67A61-211[»]
4B04X-ray2.20A/B/C/D61-211[»]
4HRFX-ray1.68A/B/C/D61-211[»]
5GTJX-ray2.00A/B/C/D39-211[»]
ProteinModelPortaliQ9BV47.
SMRiQ9BV47.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi122457. 2 interactors.
IntActiQ9BV47. 6 interactors.
STRINGi9606.ENSP00000256261.

Chemistry databases

ChEMBLiCHEMBL2295562.

PTM databases

DEPODiQ9BV47.
iPTMnetiQ9BV47.
PhosphoSitePlusiQ9BV47.

Polymorphism and mutation databases

BioMutaiDUSP26.
DMDMi74752374.

Proteomic databases

PaxDbiQ9BV47.
PeptideAtlasiQ9BV47.
PRIDEiQ9BV47.

Protocols and materials databases

DNASUi78986.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000256261; ENSP00000256261; ENSG00000133878. [Q9BV47-1]
ENST00000523956; ENSP00000429176; ENSG00000133878. [Q9BV47-1]
GeneIDi78986.
KEGGihsa:78986.
UCSCiuc003xjp.4. human. [Q9BV47-1]

Organism-specific databases

CTDi78986.
DisGeNETi78986.
GeneCardsiDUSP26.
HGNCiHGNC:28161. DUSP26.
HPAiHPA018221.
neXtProtiNX_Q9BV47.
OpenTargetsiENSG00000133878.
PharmGKBiPA142671921.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1716. Eukaryota.
COG2453. LUCA.
GeneTreeiENSGT00760000118853.
HOGENOMiHOG000233767.
HOVERGENiHBG001524.
InParanoidiQ9BV47.
KOiK14165.
OMAiYLMIRQN.
OrthoDBiEOG091G0249.
PhylomeDBiQ9BV47.
TreeFamiTF105128.

Enzyme and pathway databases

BioCyciZFISH:HS05793-MONOMER.
BRENDAi3.1.3.16. 2681.
SIGNORiQ9BV47.

Miscellaneous databases

EvolutionaryTraceiQ9BV47.
GenomeRNAii78986.
PROiQ9BV47.

Gene expression databases

BgeeiENSG00000133878.
CleanExiHS_DUSP26.
ExpressionAtlasiQ9BV47. baseline and differential.
GenevisibleiQ9BV47. HS.

Family and domain databases

CDDicd00127. DSPc. 1 hit.
Gene3Di3.90.190.10. 1 hit.
InterProiIPR020417. Atypical_DUSP.
IPR020405. Atypical_DUSP_famA.
IPR000340. Dual-sp_phosphatase_cat-dom.
IPR024950. DUSP.
IPR029021. Prot-tyrosine_phosphatase-like.
IPR016130. Tyr_Pase_AS.
IPR000387. TYR_PHOSPHATASE_dom.
IPR020422. TYR_PHOSPHATASE_DUAL_dom.
[Graphical view]
PANTHERiPTHR10159. PTHR10159. 1 hit.
PfamiPF00782. DSPc. 1 hit.
[Graphical view]
PRINTSiPR01908. ADSPHPHTASE.
PR01909. ADSPHPHTASEA.
SMARTiSM00195. DSPc. 1 hit.
[Graphical view]
SUPFAMiSSF52799. SSF52799. 1 hit.
PROSITEiPS00383. TYR_PHOSPHATASE_1. 1 hit.
PS50056. TYR_PHOSPHATASE_2. 1 hit.
PS50054. TYR_PHOSPHATASE_DUAL. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiDUS26_HUMAN
AccessioniPrimary (citable) accession number: Q9BV47
Secondary accession number(s): D3DSV8, Q9BTW0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 26, 2007
Last sequence update: June 1, 2001
Last modified: November 30, 2016
This is version 131 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 8
    Human chromosome 8: entries, gene names and cross-references to MIM
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.