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Protein

THUMP domain-containing protein 3

Gene

THUMPD3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionMethyltransferase, RNA-binding, Transferase

Names & Taxonomyi

Protein namesi
Recommended name:
THUMP domain-containing protein 3
Gene namesi
Name:THUMPD3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

EuPathDBiHostDB:ENSG00000134077.15
HGNCiHGNC:24493 THUMPD3
neXtProtiNX_Q9BV44

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000134077
PharmGKBiPA134969445

Polymorphism and mutation databases

BioMutaiTHUMPD3
DMDMi74733286

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002597691 – 507THUMP domain-containing protein 3Add BLAST507

Proteomic databases

EPDiQ9BV44
MaxQBiQ9BV44
PaxDbiQ9BV44
PeptideAtlasiQ9BV44
PRIDEiQ9BV44

PTM databases

iPTMnetiQ9BV44
PhosphoSitePlusiQ9BV44

Expressioni

Gene expression databases

BgeeiENSG00000134077
CleanExiHS_THUMPD3
ExpressionAtlasiQ9BV44 baseline and differential
GenevisibleiQ9BV44 HS

Organism-specific databases

HPAiHPA036170
HPA036171

Interactioni

Protein-protein interaction databases

BioGridi11742040 interactors.
IntActiQ9BV44 1 interactor.
STRINGi9606.ENSP00000339532

Structurei

3D structure databases

ProteinModelPortaliQ9BV44
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini165 – 285THUMPPROSITE-ProRule annotationAdd BLAST121

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi140 – 148Poly-Lys9

Sequence similaritiesi

Belongs to the methyltransferase superfamily.Curated

Phylogenomic databases

eggNOGiENOG410IEVP Eukaryota
COG0116 LUCA
GeneTreeiENSGT00530000063557
HOGENOMiHOG000007488
HOVERGENiHBG094039
InParanoidiQ9BV44
OMAiKKNWDLY
OrthoDBiEOG091G1D46
PhylomeDBiQ9BV44
TreeFamiTF313093

Family and domain databases

InterProiView protein in InterPro
IPR000241 RNA_methylase_dom
IPR029063 SAM-dependent_MTases
IPR004114 THUMP_dom
PfamiView protein in Pfam
PF02926 THUMP, 1 hit
PF01170 UPF0020, 1 hit
SMARTiView protein in SMART
SM00981 THUMP, 1 hit
SUPFAMiSSF53335 SSF53335, 1 hit
PROSITEiView protein in PROSITE
PS51165 THUMP, 1 hit
PS01261 UPF0020, 1 hit

Sequencei

Sequence statusi: Complete.

Q9BV44-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MCDIEEATNQ LLDVNLHENQ KSVQVTESDL GSESELLVTI GATVPTGFEQ
60 70 80 90 100
TAADEVREKL GSSCKISRDR GKIYFVISVE SLAQVHCLRS VDNLFVVVQE
110 120 130 140 150
FQDYQFKQTK EEVLKDFEDL AGKLPWSNPL KVWKINASFK KKKAKRKKIN
160 170 180 190 200
QNSSKEKINN GQEVKIDQRN VKKEFTSHAL DSHILDYYEN PAIKEDVSTL
210 220 230 240 250
IGDDLASCKD ETDESSKEET EPQVLKFRVT CNRAGEKHCF TSNEAARDFG
260 270 280 290 300
GAVQDYFKWK ADMTNFDVEV LLNIHDNEVI VGIALTEESL HRRNITHFGP
310 320 330 340 350
TTLRSTLAYG MLRLCDPLPY DIIVDPMCGT GAIPIEGATE WSDCFHIAGD
360 370 380 390 400
NNPLAVNRAA NNIASLLTKS QIKEGKPSWG LPIDAVQWDI CNLPLRTGSV
410 420 430 440 450
DIIVTDLPFG KRMGSKKRNW NLYPACLREM SRVCTPTTGR AVLLTQDTKC
460 470 480 490 500
FTKALSGMRH VWRKVDTVWV NVGGLRAAVY VLIRTPQAFV HPSEQDGERG

TLWQCKE
Length:507
Mass (Da):57,003
Last modified:June 1, 2001 - v1
Checksum:i0CE5587AEE817C19
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti499R → S in BAA91832 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_028976459R → Q1 PublicationCorresponds to variant dbSNP:rs1129174Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK001680 mRNA Translation: BAA91832.1
AK023263 mRNA Translation: BAB14495.1
BC001622 mRNA Translation: AAH01622.1
BC010421 mRNA Translation: AAH10421.1
AL117483 mRNA Translation: CAB55956.1
CCDSiCCDS2573.1
PIRiT17266
RefSeqiNP_001107564.1, NM_001114092.1
NP_056268.2, NM_015453.2
XP_005265078.1, XM_005265021.4
XP_005265079.1, XM_005265022.4
XP_005265080.1, XM_005265023.3
XP_005265081.1, XM_005265024.4
XP_006713149.1, XM_006713086.3
XP_011531872.1, XM_011533570.2
UniGeneiHs.443081

Genome annotation databases

EnsembliENST00000345094; ENSP00000339532; ENSG00000134077
ENST00000452837; ENSP00000395893; ENSG00000134077
ENST00000515662; ENSP00000424064; ENSG00000134077
GeneIDi25917
KEGGihsa:25917
UCSCiuc003brn.5 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiTHUM3_HUMAN
AccessioniPrimary (citable) accession number: Q9BV44
Secondary accession number(s): Q9H8V6, Q9NVC1, Q9UFS3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 28, 2006
Last sequence update: June 1, 2001
Last modified: February 28, 2018
This is version 125 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome