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Q9BV44 (THUM3_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 96. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (4) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
THUMP domain-containing protein 3
Gene names
Name:THUMPD3
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length507 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Sequence similarities

Belongs to the methyltransferase superfamily.

Contains 1 THUMP domain.

Ontologies

Keywords
   Coding sequence diversityPolymorphism
   LigandRNA-binding
   Molecular functionMethyltransferase
Transferase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Cellular_componentcytoplasm

Inferred from direct assay. Source: HPA

nucleolus

Inferred from direct assay. Source: HPA

   Molecular_functionRNA binding

Inferred from electronic annotation. Source: UniProtKB-KW

methyltransferase activity

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 507507THUMP domain-containing protein 3
PRO_0000259769

Regions

Domain165 – 285121THUMP
Compositional bias140 – 1489Poly-Lys

Natural variations

Natural variant4591R → Q. Ref.1
Corresponds to variant rs1129174 [ dbSNP | Ensembl ].
VAR_028976

Experimental info

Sequence conflict4991R → S in BAA91832. Ref.1

Sequences

Sequence LengthMass (Da)Tools
Q9BV44 [UniParc].

Last modified June 1, 2001. Version 1.
Checksum: 0CE5587AEE817C19

FASTA50757,003
        10         20         30         40         50         60 
MCDIEEATNQ LLDVNLHENQ KSVQVTESDL GSESELLVTI GATVPTGFEQ TAADEVREKL 

        70         80         90        100        110        120 
GSSCKISRDR GKIYFVISVE SLAQVHCLRS VDNLFVVVQE FQDYQFKQTK EEVLKDFEDL 

       130        140        150        160        170        180 
AGKLPWSNPL KVWKINASFK KKKAKRKKIN QNSSKEKINN GQEVKIDQRN VKKEFTSHAL 

       190        200        210        220        230        240 
DSHILDYYEN PAIKEDVSTL IGDDLASCKD ETDESSKEET EPQVLKFRVT CNRAGEKHCF 

       250        260        270        280        290        300 
TSNEAARDFG GAVQDYFKWK ADMTNFDVEV LLNIHDNEVI VGIALTEESL HRRNITHFGP 

       310        320        330        340        350        360 
TTLRSTLAYG MLRLCDPLPY DIIVDPMCGT GAIPIEGATE WSDCFHIAGD NNPLAVNRAA 

       370        380        390        400        410        420 
NNIASLLTKS QIKEGKPSWG LPIDAVQWDI CNLPLRTGSV DIIVTDLPFG KRMGSKKRNW 

       430        440        450        460        470        480 
NLYPACLREM SRVCTPTTGR AVLLTQDTKC FTKALSGMRH VWRKVDTVWV NVGGLRAAVY 

       490        500 
VLIRTPQAFV HPSEQDGERG TLWQCKE 

« Hide

References

[1]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT GLN-459.
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Eye and Placenta.
[3]"The full-ORF clone resource of the German cDNA consortium."
Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I.
BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 144-507.
Tissue: Testis.
[4]"Initial characterization of the human central proteome."
Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J.
BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AK001680 mRNA. Translation: BAA91832.1.
AK023263 mRNA. Translation: BAB14495.1.
BC001622 mRNA. Translation: AAH01622.1.
BC010421 mRNA. Translation: AAH10421.1.
AL117483 mRNA. Translation: CAB55956.1.
PIRT17266.
RefSeqNP_001107564.1. NM_001114092.1.
NP_056268.2. NM_015453.2.
XP_005265078.1. XM_005265021.2.
XP_005265079.1. XM_005265022.2.
XP_005265080.1. XM_005265023.2.
XP_005265081.1. XM_005265024.2.
UniGeneHs.443081.

3D structure databases

ProteinModelPortalQ9BV44.
SMRQ9BV44. Positions 227-482.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid117420. 13 interactions.
IntActQ9BV44. 1 interaction.
STRING9606.ENSP00000339532.

PTM databases

PhosphoSiteQ9BV44.

Polymorphism databases

DMDM74733286.

Proteomic databases

PaxDbQ9BV44.
PeptideAtlasQ9BV44.
PRIDEQ9BV44.

Protocols and materials databases

DNASU25917.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000345094; ENSP00000339532; ENSG00000134077.
ENST00000452837; ENSP00000395893; ENSG00000134077.
ENST00000515662; ENSP00000424064; ENSG00000134077.
GeneID25917.
KEGGhsa:25917.
UCSCuc003brn.4. human.

Organism-specific databases

CTD25917.
GeneCardsGC03P009410.
HGNCHGNC:24493. THUMPD3.
HPAHPA036170.
HPA036171.
neXtProtNX_Q9BV44.
PharmGKBPA134969445.
GenAtlasSearch...

Phylogenomic databases

eggNOGCOG0116.
HOGENOMHOG000007488.
HOVERGENHBG094039.
InParanoidQ9BV44.
OMARKKNWDL.
OrthoDBEOG725DH9.
PhylomeDBQ9BV44.
TreeFamTF313093.

Gene expression databases

ArrayExpressQ9BV44.
BgeeQ9BV44.
CleanExHS_THUMPD3.
GenevestigatorQ9BV44.

Family and domain databases

InterProIPR000241. RNA_methylase_dom.
IPR004114. THUMP.
[Graphical view]
PfamPF02926. THUMP. 1 hit.
PF01170. UPF0020. 1 hit.
[Graphical view]
SMARTSM00981. THUMP. 1 hit.
[Graphical view]
PROSITEPS51165. THUMP. 1 hit.
PS01261. UPF0020. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GenomeRNAi25917.
NextBio47433.
PROQ9BV44.

Entry information

Entry nameTHUM3_HUMAN
AccessionPrimary (citable) accession number: Q9BV44
Secondary accession number(s): Q9H8V6, Q9NVC1, Q9UFS3
Entry history
Integrated into UniProtKB/Swiss-Prot: November 28, 2006
Last sequence update: June 1, 2001
Last modified: April 16, 2014
This is version 96 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 3

Human chromosome 3: entries, gene names and cross-references to MIM