Q9BV44 (THUM3_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
THUMP domain-containing protein 3

Gene names

Name:

THUMPD3

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	507 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Sequence similarities

Belongs to the methyltransferase superfamily. Contains 1 THUMP domain.

Ontologies

Keywords
Coding sequence diversity	Polymorphism
Ligand	RNA-binding
Molecular function	Methyltransferase Transferase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Molecular function	RNA binding Inferred from electronic annotation. Source: UniProtKB-KW methyltransferase activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 507	507	THUMP domain-containing protein 3		PRO_0000259769
Regions
	Domain	165 – 285	121	THUMP
	Compositional bias	140 – 148	9	Poly-Lys
Natural variations
	Natural variant	459	1	R → Q. Ref.1 Corresponds to variant rs1129174 [ dbSNP | Ensembl ].		VAR_028976
Experimental info
	Sequence conflict	499	1	R → S in BAA91832. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	Q9BV44 [UniParc]. Last modified June 1, 2001. Version 1. Checksum: 0CE5587AEE817C19	FASTA	507	57,003
	10 20 30 40 50 60 MCDIEEATNQ LLDVNLHENQ KSVQVTESDL GSESELLVTI GATVPTGFEQ TAADEVREKL 70 80 90 100 110 120 GSSCKISRDR GKIYFVISVE SLAQVHCLRS VDNLFVVVQE FQDYQFKQTK EEVLKDFEDL 130 140 150 160 170 180 AGKLPWSNPL KVWKINASFK KKKAKRKKIN QNSSKEKINN GQEVKIDQRN VKKEFTSHAL 190 200 210 220 230 240 DSHILDYYEN PAIKEDVSTL IGDDLASCKD ETDESSKEET EPQVLKFRVT CNRAGEKHCF 250 260 270 280 290 300 TSNEAARDFG GAVQDYFKWK ADMTNFDVEV LLNIHDNEVI VGIALTEESL HRRNITHFGP 310 320 330 340 350 360 TTLRSTLAYG MLRLCDPLPY DIIVDPMCGT GAIPIEGATE WSDCFHIAGD NNPLAVNRAA 370 380 390 400 410 420 NNIASLLTKS QIKEGKPSWG LPIDAVQWDI CNLPLRTGSV DIIVTDLPFG KRMGSKKRNW 430 440 450 460 470 480 NLYPACLREM SRVCTPTTGR AVLLTQDTKC FTKALSGMRH VWRKVDTVWV NVGGLRAAVY 490 500 VLIRTPQAFV HPSEQDGERG TLWQCKE

References

[1]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed: 14702039] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT GLN-459.
[2]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Eye and Placenta.
[3]	"The full-ORF clone resource of the German cDNA consortium." Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I. BMC Genomics 8:399-399(2007) [PubMed: 17974005] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 144-507. Tissue: Testis.
[4]	"Initial characterization of the human central proteome." Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J. BMC Syst. Biol. 5:17-17(2011) [PubMed: 21269460] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Cross-references

Sequence databases
EMBL GenBank DDBJ	AK001680 mRNA. Translation: BAA91832.1. AK023263 mRNA. Translation: BAB14495.1. BC001622 mRNA. Translation: AAH01622.1. BC010421 mRNA. Translation: AAH10421.1. AL117483 mRNA. Translation: CAB55956.1.
IPI	IPI00306127.
PIR	T17266.
RefSeq	NP_001107564.1. NM_001114092.1. NP_056268.2. NM_015453.2.
UniGene	Hs.443081.
3D structure databases
ProteinModelPortal	Q9BV44.
SMR	Q9BV44. Positions 298-444.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q9BV44. 1 interaction.
PTM databases
PhosphoSite	Q9BV44.
Polymorphism databases
DMDM	74733286.
Proteomic databases
PeptideAtlas	Q9BV44.
PRIDE	Q9BV44.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000345094; ENSP00000339532; ENSG00000134077. ENST00000404270; ENSP00000384270; ENSG00000134077. ENST00000452837; ENSP00000395893; ENSG00000134077.
GeneID	25917.
KEGG	hsa:25917.
UCSC	uc003brn.2. human.
Organism-specific databases
CTD	25917.
GeneCards	GC03P009406.
H-InvDB	HIX0003026.
HGNC	HGNC:24493. THUMPD3.
HPA	HPA036170.
neXtProt	NX_Q9BV44.
PharmGKB	PA134969445.
GenAtlas	Search...
Phylogenomic databases
eggNOG	prNOG17125.
GeneTree	ENSGT00530000063557.
HOGENOM	HBG385044.
HOVERGEN	HBG094039.
InParanoid	Q9BV44.
OMA	EHLQVTI.
OrthoDB	EOG44MXS7.
PhylomeDB	Q9BV44.
Gene expression databases
ArrayExpress	Q9BV44.
Bgee	Q9BV44.
CleanEx	HS_THUMPD3.
Genevestigator	Q9BV44.
GermOnline	ENSG00000134077. Homo sapiens.
Family and domain databases
InterPro	IPR000241. RNA_methylase. IPR004114. THUMP. [Graphical view]
Pfam	PF02926. THUMP. 1 hit. PF01170. UPF0020. 1 hit. [Graphical view]
SMART	SM00981. THUMP. 1 hit. [Graphical view]
PROSITE	PS51165. THUMP. 1 hit. PS01261. UPF0020. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	47433.

Entry information

Entry name

THUM3_HUMAN

Accession

Primary (citable) accession number: Q9BV44
Secondary accession number(s): Q9H8V6, Q9NVC1, Q9UFS3

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 28, 2006
Last sequence update:	June 1, 2001
Last modified:	January 25, 2012
This is version 75 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.