Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

THUMP domain-containing protein 3

Gene

THUMPD3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Methyltransferase, Transferase

Keywords - Ligandi

RNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
THUMP domain-containing protein 3
Gene namesi
Name:THUMPD3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

HGNCiHGNC:24493. THUMPD3.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134969445.

Polymorphism and mutation databases

BioMutaiTHUMPD3.
DMDMi74733286.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 507507THUMP domain-containing protein 3PRO_0000259769Add
BLAST

Proteomic databases

EPDiQ9BV44.
MaxQBiQ9BV44.
PaxDbiQ9BV44.
PeptideAtlasiQ9BV44.
PRIDEiQ9BV44.

PTM databases

iPTMnetiQ9BV44.
PhosphoSiteiQ9BV44.

Expressioni

Gene expression databases

BgeeiQ9BV44.
CleanExiHS_THUMPD3.
ExpressionAtlasiQ9BV44. baseline and differential.
GenevisibleiQ9BV44. HS.

Organism-specific databases

HPAiHPA036170.
HPA036171.

Interactioni

Protein-protein interaction databases

BioGridi117420. 37 interactions.
IntActiQ9BV44. 1 interaction.
STRINGi9606.ENSP00000339532.

Structurei

3D structure databases

ProteinModelPortaliQ9BV44.
SMRiQ9BV44. Positions 227-482.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini165 – 285121THUMPPROSITE-ProRule annotationAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi140 – 1489Poly-Lys

Sequence similaritiesi

Belongs to the methyltransferase superfamily.Curated
Contains 1 THUMP domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiENOG410IEVP. Eukaryota.
COG0116. LUCA.
GeneTreeiENSGT00530000063557.
HOGENOMiHOG000007488.
HOVERGENiHBG094039.
InParanoidiQ9BV44.
OMAiGHLWRKV.
OrthoDBiEOG725DH9.
PhylomeDBiQ9BV44.
TreeFamiTF313093.

Family and domain databases

Gene3Di3.40.50.150. 1 hit.
InterProiIPR000241. RNA_methylase_dom.
IPR029063. SAM-dependent_MTases.
IPR004114. THUMP_dom.
[Graphical view]
PfamiPF02926. THUMP. 1 hit.
PF01170. UPF0020. 1 hit.
[Graphical view]
SMARTiSM00981. THUMP. 1 hit.
[Graphical view]
SUPFAMiSSF53335. SSF53335. 1 hit.
PROSITEiPS51165. THUMP. 1 hit.
PS01261. UPF0020. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9BV44-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MCDIEEATNQ LLDVNLHENQ KSVQVTESDL GSESELLVTI GATVPTGFEQ
60 70 80 90 100
TAADEVREKL GSSCKISRDR GKIYFVISVE SLAQVHCLRS VDNLFVVVQE
110 120 130 140 150
FQDYQFKQTK EEVLKDFEDL AGKLPWSNPL KVWKINASFK KKKAKRKKIN
160 170 180 190 200
QNSSKEKINN GQEVKIDQRN VKKEFTSHAL DSHILDYYEN PAIKEDVSTL
210 220 230 240 250
IGDDLASCKD ETDESSKEET EPQVLKFRVT CNRAGEKHCF TSNEAARDFG
260 270 280 290 300
GAVQDYFKWK ADMTNFDVEV LLNIHDNEVI VGIALTEESL HRRNITHFGP
310 320 330 340 350
TTLRSTLAYG MLRLCDPLPY DIIVDPMCGT GAIPIEGATE WSDCFHIAGD
360 370 380 390 400
NNPLAVNRAA NNIASLLTKS QIKEGKPSWG LPIDAVQWDI CNLPLRTGSV
410 420 430 440 450
DIIVTDLPFG KRMGSKKRNW NLYPACLREM SRVCTPTTGR AVLLTQDTKC
460 470 480 490 500
FTKALSGMRH VWRKVDTVWV NVGGLRAAVY VLIRTPQAFV HPSEQDGERG

TLWQCKE
Length:507
Mass (Da):57,003
Last modified:June 1, 2001 - v1
Checksum:i0CE5587AEE817C19
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti499 – 4991R → S in BAA91832 (PubMed:14702039).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti459 – 4591R → Q.1 Publication
Corresponds to variant rs1129174 [ dbSNP | Ensembl ].
VAR_028976

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK001680 mRNA. Translation: BAA91832.1.
AK023263 mRNA. Translation: BAB14495.1.
BC001622 mRNA. Translation: AAH01622.1.
BC010421 mRNA. Translation: AAH10421.1.
AL117483 mRNA. Translation: CAB55956.1.
CCDSiCCDS2573.1.
PIRiT17266.
RefSeqiNP_001107564.1. NM_001114092.1.
NP_056268.2. NM_015453.2.
XP_005265078.1. XM_005265021.3.
XP_005265079.1. XM_005265022.3.
XP_005265080.1. XM_005265023.2.
XP_005265081.1. XM_005265024.3.
XP_006713149.1. XM_006713086.2.
XP_011531872.1. XM_011533570.1.
UniGeneiHs.443081.

Genome annotation databases

EnsembliENST00000345094; ENSP00000339532; ENSG00000134077.
ENST00000452837; ENSP00000395893; ENSG00000134077.
ENST00000515662; ENSP00000424064; ENSG00000134077.
GeneIDi25917.
KEGGihsa:25917.
UCSCiuc003brn.5. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK001680 mRNA. Translation: BAA91832.1.
AK023263 mRNA. Translation: BAB14495.1.
BC001622 mRNA. Translation: AAH01622.1.
BC010421 mRNA. Translation: AAH10421.1.
AL117483 mRNA. Translation: CAB55956.1.
CCDSiCCDS2573.1.
PIRiT17266.
RefSeqiNP_001107564.1. NM_001114092.1.
NP_056268.2. NM_015453.2.
XP_005265078.1. XM_005265021.3.
XP_005265079.1. XM_005265022.3.
XP_005265080.1. XM_005265023.2.
XP_005265081.1. XM_005265024.3.
XP_006713149.1. XM_006713086.2.
XP_011531872.1. XM_011533570.1.
UniGeneiHs.443081.

3D structure databases

ProteinModelPortaliQ9BV44.
SMRiQ9BV44. Positions 227-482.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi117420. 37 interactions.
IntActiQ9BV44. 1 interaction.
STRINGi9606.ENSP00000339532.

PTM databases

iPTMnetiQ9BV44.
PhosphoSiteiQ9BV44.

Polymorphism and mutation databases

BioMutaiTHUMPD3.
DMDMi74733286.

Proteomic databases

EPDiQ9BV44.
MaxQBiQ9BV44.
PaxDbiQ9BV44.
PeptideAtlasiQ9BV44.
PRIDEiQ9BV44.

Protocols and materials databases

DNASUi25917.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000345094; ENSP00000339532; ENSG00000134077.
ENST00000452837; ENSP00000395893; ENSG00000134077.
ENST00000515662; ENSP00000424064; ENSG00000134077.
GeneIDi25917.
KEGGihsa:25917.
UCSCiuc003brn.5. human.

Organism-specific databases

CTDi25917.
GeneCardsiTHUMPD3.
HGNCiHGNC:24493. THUMPD3.
HPAiHPA036170.
HPA036171.
neXtProtiNX_Q9BV44.
PharmGKBiPA134969445.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IEVP. Eukaryota.
COG0116. LUCA.
GeneTreeiENSGT00530000063557.
HOGENOMiHOG000007488.
HOVERGENiHBG094039.
InParanoidiQ9BV44.
OMAiGHLWRKV.
OrthoDBiEOG725DH9.
PhylomeDBiQ9BV44.
TreeFamiTF313093.

Miscellaneous databases

GenomeRNAii25917.
PROiQ9BV44.

Gene expression databases

BgeeiQ9BV44.
CleanExiHS_THUMPD3.
ExpressionAtlasiQ9BV44. baseline and differential.
GenevisibleiQ9BV44. HS.

Family and domain databases

Gene3Di3.40.50.150. 1 hit.
InterProiIPR000241. RNA_methylase_dom.
IPR029063. SAM-dependent_MTases.
IPR004114. THUMP_dom.
[Graphical view]
PfamiPF02926. THUMP. 1 hit.
PF01170. UPF0020. 1 hit.
[Graphical view]
SMARTiSM00981. THUMP. 1 hit.
[Graphical view]
SUPFAMiSSF53335. SSF53335. 1 hit.
PROSITEiPS51165. THUMP. 1 hit.
PS01261. UPF0020. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT GLN-459.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Eye and Placenta.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 144-507.
    Tissue: Testis.
  4. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  5. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."
    Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D., Wang L., Ye M., Zou H.
    J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.

Entry informationi

Entry nameiTHUM3_HUMAN
AccessioniPrimary (citable) accession number: Q9BV44
Secondary accession number(s): Q9H8V6, Q9NVC1, Q9UFS3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 28, 2006
Last sequence update: June 1, 2001
Last modified: July 6, 2016
This is version 114 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.