ID   Q9BV39_HUMAN            Unreviewed;       316 AA.
AC   Q9BV39;
DT   01-JUN-2001, integrated into UniProtKB/TrEMBL.
DT   01-JUN-2001, sequence version 1.
DT   24-JAN-2024, entry version 110.
DE   RecName: Full=Multidrug resistance-associated protein 1 {ECO:0000256|ARBA:ARBA00041009};
DE   AltName: Full=ATP-binding cassette sub-family C member 1 {ECO:0000256|ARBA:ARBA00042274};
DE   AltName: Full=Glutathione-S-conjugate-translocating ATPase ABCC1 {ECO:0000256|ARBA:ARBA00041913};
DE   AltName: Full=Leukotriene C(4) transporter {ECO:0000256|ARBA:ARBA00041345};
DE   Flags: Fragment;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|EMBL:AAH01636.1};
RN   [1] {ECO:0000313|EMBL:AAH01636.1}
RP   NUCLEOTIDE SEQUENCE.
RC   TISSUE=Eye {ECO:0000313|EMBL:AAH01636.1};
RA   Strausberg R.;
RL   Submitted (JAN-2001) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=17beta-estradiol 17-O-(beta-D-glucuronate)(in) + ATP + H2O =
CC         17beta-estradiol 17-O-(beta-D-glucuronate)(out) + ADP + H(+) +
CC         phosphate; Xref=Rhea:RHEA:60128, ChEBI:CHEBI:15377,
CC         ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:43474,
CC         ChEBI:CHEBI:82961, ChEBI:CHEBI:456216;
CC         Evidence={ECO:0000256|ARBA:ARBA00000793};
CC       PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:60129;
CC         Evidence={ECO:0000256|ARBA:ARBA00000793};
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=2',3'-cGAMP(in) + ATP + H2O = 2',3'-cGAMP(out) + ADP + H(+) +
CC         phosphate; Xref=Rhea:RHEA:74887, ChEBI:CHEBI:15377,
CC         ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:43474,
CC         ChEBI:CHEBI:143093, ChEBI:CHEBI:456216;
CC         Evidence={ECO:0000256|ARBA:ARBA00036427};
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + H2O + sphing-4-enine 1-phosphate(in) = ADP + H(+) +
CC         phosphate + sphing-4-enine 1-phosphate(out); Xref=Rhea:RHEA:38951,
CC         ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC         ChEBI:CHEBI:43474, ChEBI:CHEBI:60119, ChEBI:CHEBI:456216;
CC         Evidence={ECO:0000256|ARBA:ARBA00001064};
CC       PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:38952;
CC         Evidence={ECO:0000256|ARBA:ARBA00001064};
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + H2O + vincristine(in) = ADP + H(+) + phosphate +
CC         vincristine(out); Xref=Rhea:RHEA:60160, ChEBI:CHEBI:15377,
CC         ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:43474,
CC         ChEBI:CHEBI:143658, ChEBI:CHEBI:456216;
CC         Evidence={ECO:0000256|ARBA:ARBA00036384};
CC       PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:60161;
CC         Evidence={ECO:0000256|ARBA:ARBA00036384};
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + daunorubicin(in) + H2O = ADP + daunorubicin(out) + H(+)
CC         + phosphate; Xref=Rhea:RHEA:33147, ChEBI:CHEBI:15377,
CC         ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:43474,
CC         ChEBI:CHEBI:64677, ChEBI:CHEBI:456216;
CC         Evidence={ECO:0000256|ARBA:ARBA00036199};
CC       PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:33148;
CC         Evidence={ECO:0000256|ARBA:ARBA00036199};
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DR   EMBL; BC001636; AAH01636.1; -; mRNA.
DR   AlphaFoldDB; Q9BV39; -.
DR   PeptideAtlas; Q9BV39; -.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR   CDD; cd03244; ABCC_MRP_domain2; 1.
DR   Gene3D; 1.20.1560.10; ABC transporter type 1, transmembrane domain; 1.
DR   Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR036640; ABC1_TM_sf.
DR   InterPro; IPR003439; ABC_transporter-like_ATP-bd.
DR   InterPro; IPR017871; ABC_transporter-like_CS.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR24223; ATP-BINDING CASSETTE SUB-FAMILY C; 1.
DR   PANTHER; PTHR24223:SF241; MULTIDRUG RESISTANCE-ASSOCIATED PROTEIN 1; 1.
DR   Pfam; PF00005; ABC_tran; 1.
DR   SMART; SM00382; AAA; 1.
DR   SUPFAM; SSF90123; ABC transporter transmembrane region; 1.
DR   SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR   PROSITE; PS00211; ABC_TRANSPORTER_1; 1.
DR   PROSITE; PS50893; ABC_TRANSPORTER_2; 1.
PE   2: Evidence at transcript level;
KW   ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136};
KW   Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989}.
FT   DOMAIN          78..312
FT                   /note="ABC transporter"
FT                   /evidence="ECO:0000259|PROSITE:PS50893"
FT   NON_TER         1
FT                   /evidence="ECO:0000313|EMBL:AAH01636.1"
SQ   SEQUENCE   316 AA;  35334 MW;  BA17D63E77731637 CRC64;
     LFAVISRHSL SAGLVGLSVS YSLQVTTYLN WLVRMSSEME TNIVAVERLK EYSETEKEAP
     WQIQETAPPS SWPQVGRVEF RNYCLRYRED LDFVLRHINV TINGGEKVGI VGRTGAGKSS
     LTLGLFRINE SAEGEIIIDG INIAKIGLHD LRFKITIIPQ DPVLFSGSLR MNLDPFSQYS
     DEEVWTSLEL AHLKDFVSAL PDKLDHECAE GGENLSVGQR QLVCLARALL RKTKILVLDE
     ATAAVDLETD DLIQSTIRTQ FEDCTVLTIA HRLNTIMDYT RVIVLDKGEI QEYGAPSDLL
     QQRGLFYSMA KDAGLV
//