Q9BV38 (WDR18_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
WD repeat-containing protein 18

Gene names

Name:

WDR18

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	432 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	May play a role during development By similarity.
Sequence similarities	Belongs to the WD repeat WDR18 family. Contains 6 WD repeats.
Sequence caution	The sequence AAC12679.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.

Ontologies

Keywords
Coding sequence diversity	Polymorphism
Domain	Repeat WD repeat
Molecular function	Developmental protein
PTM	Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	multicellular organismal development Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 432	432	WD repeat-containing protein 18		PRO_0000051365
Regions
	Repeat	36 – 75	40	WD 1
	Repeat	78 – 116	39	WD 2
	Repeat	119 – 158	40	WD 3
	Repeat	170 – 211	42	WD 4
	Repeat	213 – 257	45	WD 5
	Repeat	267 – 306	40	WD 6
Amino acid modifications
	Modified residue	61	1	Phosphotyrosine Ref.3
Natural variations
	Natural variant	172	1	A → T. Ref.2 Corresponds to variant rs2158367 [ dbSNP | Ensembl ].		VAR_031577
	Natural variant	213	1	L → F. Corresponds to variant rs35068100 [ dbSNP | Ensembl ].		VAR_031578
	Natural variant	264	1	V → I. Corresponds to variant rs11538683 [ dbSNP | Ensembl ].		VAR_031579
Experimental info
	Sequence conflict	198 – 199	2	Missing in AAC12679. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	Q9BV38 [UniParc]. Last modified April 3, 2007. Version 2. Checksum: 0E00FA0DF124F82C	FASTA	432	47,405
	10 20 30 40 50 60 MAAPMEVAVC TDSAAPMWSC IVWELHSGAN LLTYRGGQAG PRGLALLNGE YLLAAQLGKN 70 80 90 100 110 120 YISAWELQRK DQLQQKIMCP GPVTCLTASP NGLYVLAGVA ESIHLWEVST GNLLVILSRH 130 140 150 160 170 180 YQDVSCLQFT GDSSHFISGG KDCLVLVWSL CSVLQADPSR IPAPRHVWSH HALPITDLHC 190 200 210 220 230 240 GFGGPLARVA TSSLDQTVKL WEVSSGELLL SVLFDVSIMA VTMDLAEHHM FCGGSEGSIF 250 260 270 280 290 300 QVDLFTWPGQ RERSFHPEQD AGKVFKGHRN QVTCLSVSTD GSVLLSGSHD ETVRLWDVQS 310 320 330 340 350 360 KQCIRTVALK GPVTNAAILL APVSMLSSDF RPSLPLPHFN KHLLGAEHGD EPRHGGLTLR 370 380 390 400 410 420 LGLHQQGSEP SYLDRTEQLQ AVLCSTMEKS VLGGQDQLRV RVTELEDEVR NLRKINRDLF 430 DFSTRFITRP AK

References

[1]	"The DNA sequence and biology of human chromosome 19." Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V. , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M. Nature 428:529-535(2004) [PubMed: 15057824] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[2]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT THR-172. Tissue: Brain and Lung.
[3]	"Global survey of phosphotyrosine signaling identifies oncogenic kinases in lung cancer." Rikova K., Guo A., Zeng Q., Possemato A., Yu J., Haack H., Nardone J., Lee K., Reeves C., Li Y., Hu Y., Tan Z., Stokes M., Sullivan L., Mitchell J., Wetzel R., Macneill J., Ren J.M. , Yuan J., Bakalarski C.E., Villen J., Kornhauser J.M., Smith B., Li D., Zhou X., Gygi S.P., Gu T.-L., Polakiewicz R.D., Rush J., Comb M.J. Cell 131:1190-1203(2007) [PubMed: 18083107] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-61, MASS SPECTROMETRY. Tissue: Lung carcinoma.
[4]	"Initial characterization of the human central proteome." Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J. BMC Syst. Biol. 5:17-17(2011) [PubMed: 21269460] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AC004528 Genomic DNA. Translation: AAC12679.1. Different initiation. BC000040 mRNA. Translation: AAH00040.2. BC001648 mRNA. Translation: AAH01648.1.
IPI	IPI00032533.
RefSeq	NP_077005.2. NM_024100.3.
UniGene	Hs.325321.
3D structure databases
ProteinModelPortal	Q9BV38.
SMR	Q9BV38. Positions 13-407.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q9BV38. 5 interactions.
MINT	MINT-1388285.
STRING	Q9BV38.
PTM databases
PhosphoSite	Q9BV38.
Polymorphism databases
DMDM	143811475.
Proteomic databases
PeptideAtlas	Q9BV38.
PRIDE	Q9BV38.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000251289; ENSP00000251289; ENSG00000065268.
GeneID	57418.
KEGG	hsa:57418.
NMPDR	fig|9606.3.peg.15250.
UCSC	uc002lqm.1. human.
Organism-specific databases
CTD	57418.
GeneCards	GC19P000935.
H-InvDB	HIX0014566.
HGNC	HGNC:17956. WDR18.
neXtProt	NX_Q9BV38.
PharmGKB	PA38269.
GenAtlas	Search...
Phylogenomic databases
eggNOG	prNOG16435.
GeneTree	ENSGT00390000000289.
HOGENOM	HBG717431.
HOVERGEN	HBG059735.
InParanoid	Q9BV38.
OMA	FCGGSDG.
OrthoDB	EOG4PZJ6K.
PhylomeDB	Q9BV38.
Gene expression databases
ArrayExpress	Q9BV38.
Bgee	Q9BV38.
CleanEx	HS_WDR18.
Genevestigator	Q9BV38.
GermOnline	ENSG00000065268. Homo sapiens.
Family and domain databases
InterPro	IPR020472. G-protein_beta_WD-40_rep. IPR015943. WD40/YVTN_repeat-like_dom. IPR001680. WD40_repeat. IPR011046. WD40_repeat-like_dom. IPR019775. WD40_repeat_CS. IPR017986. WD40_repeat_dom. [Graphical view]
Gene3D	G3DSA:2.130.10.10. WD40/YVTN_repeat-like. 1 hit.
Pfam	PF00400. WD40. 3 hits. [Graphical view]
PRINTS	PR00320. GPROTEINBRPT.
SMART	SM00320. WD40. 4 hits. [Graphical view]
SUPFAM	SSF50978. WD40_like. 1 hit.
PROSITE	PS00678. WD_REPEATS_1. 2 hits. PS50082. WD_REPEATS_2. 3 hits. PS50294. WD_REPEATS_REGION. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	63562.

Entry information

Entry name

WDR18_HUMAN

Accession

Primary (citable) accession number: Q9BV38
Secondary accession number(s): O60390, Q9BWR2

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 27, 2002
Last sequence update:	April 3, 2007
Last modified:	January 25, 2012
This is version 92 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.