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Protein

WD repeat-containing protein 18

Gene

WDR18

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

May play a role during development (By similarity). Functions as a component of the Five Friends of Methylated CHTOP (5FMC) complex; the 5FMC complex is recruited to ZNF148 by methylated CHTOP, leading to desumoylation of ZNF148 and subsequent transactivation of ZNF148 target genes.By similarity1 Publication

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Enzyme and pathway databases

ReactomeiR-HSA-6791226. Major pathway of rRNA processing in the nucleolus.
SignaLinkiQ9BV38.

Names & Taxonomyi

Protein namesi
Recommended name:
WD repeat-containing protein 18
Gene namesi
Name:WDR18
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

HGNCiHGNC:17956. WDR18.

Subcellular locationi

  • Nucleusnucleoplasm By similarity
  • Cytoplasm By similarity

  • Note: Mainly found in the nucleoplasm, with low levels detected in the cytoplasmic and chromatin fractions.By similarity

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA38269.

Polymorphism and mutation databases

BioMutaiWDR18.
DMDMi143811475.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 432432WD repeat-containing protein 18PRO_0000051365Add
BLAST

Proteomic databases

EPDiQ9BV38.
MaxQBiQ9BV38.
PaxDbiQ9BV38.
PeptideAtlasiQ9BV38.
PRIDEiQ9BV38.
TopDownProteomicsiQ9BV38.

PTM databases

iPTMnetiQ9BV38.
PhosphoSiteiQ9BV38.

Expressioni

Gene expression databases

BgeeiQ9BV38.
CleanExiHS_WDR18.
ExpressionAtlasiQ9BV38. baseline and differential.
GenevisibleiQ9BV38. HS.

Organism-specific databases

HPAiHPA050193.
HPA050200.

Interactioni

Subunit structurei

Component of the 5FMC complex, at least composed of PELP1, LAS1L, TEX10, WDR18 and SENP3; the complex interacts with methylated CHTOP and ZNF148. Interacts with NOL9.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
PELP1Q8IZL83EBI-727429,EBI-716449
SENP3Q9H4L43EBI-727429,EBI-2880236

Protein-protein interaction databases

BioGridi121517. 49 interactions.
IntActiQ9BV38. 25 interactions.
MINTiMINT-1388285.
STRINGi9606.ENSP00000251289.

Structurei

3D structure databases

ProteinModelPortaliQ9BV38.
SMRiQ9BV38. Positions 7-335.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati36 – 7540WD 1Add
BLAST
Repeati78 – 11639WD 2Add
BLAST
Repeati119 – 15840WD 3Add
BLAST
Repeati170 – 21142WD 4Add
BLAST
Repeati213 – 25745WD 5Add
BLAST
Repeati267 – 30640WD 6Add
BLAST

Sequence similaritiesi

Belongs to the WD repeat WDR18 family.Curated
Contains 6 WD repeats.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, WD repeat

Phylogenomic databases

eggNOGiENOG410INVM. Eukaryota.
ENOG410ZP68. LUCA.
GeneTreeiENSGT00390000000289.
HOGENOMiHOG000046506.
HOVERGENiHBG059735.
InParanoidiQ9BV38.
KOiK14829.
OMAiVDLFTWP.
OrthoDBiEOG72NRQ1.
PhylomeDBiQ9BV38.
TreeFamiTF313046.

Family and domain databases

Gene3Di2.130.10.10. 2 hits.
InterProiIPR020472. G-protein_beta_WD-40_rep.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR019775. WD40_repeat_CS.
IPR017986. WD40_repeat_dom.
IPR026987. Wdr18_C_dom.
[Graphical view]
PfamiPF00400. WD40. 3 hits.
PF14077. WD40_alt. 1 hit.
[Graphical view]
PRINTSiPR00320. GPROTEINBRPT.
SMARTiSM00320. WD40. 4 hits.
[Graphical view]
SUPFAMiSSF50978. SSF50978. 1 hit.
PROSITEiPS00678. WD_REPEATS_1. 2 hits.
PS50082. WD_REPEATS_2. 3 hits.
PS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9BV38-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAPMEVAVC TDSAAPMWSC IVWELHSGAN LLTYRGGQAG PRGLALLNGE
60 70 80 90 100
YLLAAQLGKN YISAWELQRK DQLQQKIMCP GPVTCLTASP NGLYVLAGVA
110 120 130 140 150
ESIHLWEVST GNLLVILSRH YQDVSCLQFT GDSSHFISGG KDCLVLVWSL
160 170 180 190 200
CSVLQADPSR IPAPRHVWSH HALPITDLHC GFGGPLARVA TSSLDQTVKL
210 220 230 240 250
WEVSSGELLL SVLFDVSIMA VTMDLAEHHM FCGGSEGSIF QVDLFTWPGQ
260 270 280 290 300
RERSFHPEQD AGKVFKGHRN QVTCLSVSTD GSVLLSGSHD ETVRLWDVQS
310 320 330 340 350
KQCIRTVALK GPVTNAAILL APVSMLSSDF RPSLPLPHFN KHLLGAEHGD
360 370 380 390 400
EPRHGGLTLR LGLHQQGSEP SYLDRTEQLQ AVLCSTMEKS VLGGQDQLRV
410 420 430
RVTELEDEVR NLRKINRDLF DFSTRFITRP AK
Length:432
Mass (Da):47,405
Last modified:April 3, 2007 - v2
Checksum:i0E00FA0DF124F82C
GO

Sequence cautioni

The sequence AAC12679.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti198 – 1992Missing in AAC12679 (PubMed:15057824).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti172 – 1721A → T.1 Publication
Corresponds to variant rs2158367 [ dbSNP | Ensembl ].
VAR_031577
Natural varianti213 – 2131L → F.
Corresponds to variant rs35068100 [ dbSNP | Ensembl ].
VAR_031578
Natural varianti264 – 2641V → I.
Corresponds to variant rs11538683 [ dbSNP | Ensembl ].
VAR_031579

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC004528 Genomic DNA. Translation: AAC12679.1. Different initiation.
BC000040 mRNA. Translation: AAH00040.2.
BC001648 mRNA. Translation: AAH01648.1.
CCDSiCCDS12051.1.
RefSeqiNP_077005.2. NM_024100.3.
UniGeneiHs.325321.

Genome annotation databases

EnsembliENST00000585809; ENSP00000476117; ENSG00000065268.
GeneIDi57418.
KEGGihsa:57418.
UCSCiuc002lqm.2. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC004528 Genomic DNA. Translation: AAC12679.1. Different initiation.
BC000040 mRNA. Translation: AAH00040.2.
BC001648 mRNA. Translation: AAH01648.1.
CCDSiCCDS12051.1.
RefSeqiNP_077005.2. NM_024100.3.
UniGeneiHs.325321.

3D structure databases

ProteinModelPortaliQ9BV38.
SMRiQ9BV38. Positions 7-335.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi121517. 49 interactions.
IntActiQ9BV38. 25 interactions.
MINTiMINT-1388285.
STRINGi9606.ENSP00000251289.

PTM databases

iPTMnetiQ9BV38.
PhosphoSiteiQ9BV38.

Polymorphism and mutation databases

BioMutaiWDR18.
DMDMi143811475.

Proteomic databases

EPDiQ9BV38.
MaxQBiQ9BV38.
PaxDbiQ9BV38.
PeptideAtlasiQ9BV38.
PRIDEiQ9BV38.
TopDownProteomicsiQ9BV38.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000585809; ENSP00000476117; ENSG00000065268.
GeneIDi57418.
KEGGihsa:57418.
UCSCiuc002lqm.2. human.

Organism-specific databases

CTDi57418.
GeneCardsiWDR18.
HGNCiHGNC:17956. WDR18.
HPAiHPA050193.
HPA050200.
neXtProtiNX_Q9BV38.
PharmGKBiPA38269.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410INVM. Eukaryota.
ENOG410ZP68. LUCA.
GeneTreeiENSGT00390000000289.
HOGENOMiHOG000046506.
HOVERGENiHBG059735.
InParanoidiQ9BV38.
KOiK14829.
OMAiVDLFTWP.
OrthoDBiEOG72NRQ1.
PhylomeDBiQ9BV38.
TreeFamiTF313046.

Enzyme and pathway databases

ReactomeiR-HSA-6791226. Major pathway of rRNA processing in the nucleolus.
SignaLinkiQ9BV38.

Miscellaneous databases

GenomeRNAii57418.
PROiQ9BV38.

Gene expression databases

BgeeiQ9BV38.
CleanExiHS_WDR18.
ExpressionAtlasiQ9BV38. baseline and differential.
GenevisibleiQ9BV38. HS.

Family and domain databases

Gene3Di2.130.10.10. 2 hits.
InterProiIPR020472. G-protein_beta_WD-40_rep.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR019775. WD40_repeat_CS.
IPR017986. WD40_repeat_dom.
IPR026987. Wdr18_C_dom.
[Graphical view]
PfamiPF00400. WD40. 3 hits.
PF14077. WD40_alt. 1 hit.
[Graphical view]
PRINTSiPR00320. GPROTEINBRPT.
SMARTiSM00320. WD40. 4 hits.
[Graphical view]
SUPFAMiSSF50978. SSF50978. 1 hit.
PROSITEiPS00678. WD_REPEATS_1. 2 hits.
PS50082. WD_REPEATS_2. 3 hits.
PS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The DNA sequence and biology of human chromosome 19."
    Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V.
    , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M.
    Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT THR-172.
    Tissue: Brain and Lung.
  3. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  4. "Five friends of methylated chromatin target of protein-arginine-methyltransferase[prmt]-1 (chtop), a complex linking arginine methylation to desumoylation."
    Fanis P., Gillemans N., Aghajanirefah A., Pourfarzad F., Demmers J., Esteghamat F., Vadlamudi R.K., Grosveld F., Philipsen S., van Dijk T.B.
    Mol. Cell. Proteomics 11:1263-1273(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, IDENTIFICATION IN THE 5FMC COMPLEX.

Entry informationi

Entry nameiWDR18_HUMAN
AccessioniPrimary (citable) accession number: Q9BV38
Secondary accession number(s): O60390, Q9BWR2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 27, 2002
Last sequence update: April 3, 2007
Last modified: July 6, 2016
This is version 138 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.