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Protein

Uncharacterized protein C15orf57

Gene

C15orf57

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Uncharacterized protein C15orf57
Alternative name(s):
Protein CCDC32
Gene namesi
Name:C15orf57
Synonyms:CCDC32
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 15

Organism-specific databases

HGNCiHGNC:28295. C15orf57.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA162378234.

Polymorphism and mutation databases

BioMutaiC15orf57.
DMDMi74733283.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 185185Uncharacterized protein C15orf57PRO_0000298937Add
BLAST

Proteomic databases

EPDiQ9BV29.
MaxQBiQ9BV29.
PaxDbiQ9BV29.
PRIDEiQ9BV29.

PTM databases

iPTMnetiQ9BV29.
PhosphoSiteiQ9BV29.

Expressioni

Gene expression databases

BgeeiQ9BV29.
CleanExiHS_C15orf57.
ExpressionAtlasiQ9BV29. baseline and differential.
GenevisibleiQ9BV29. HS.

Organism-specific databases

HPAiHPA041688.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
POT1Q9NUX52EBI-2874058,EBI-752420

Protein-protein interaction databases

BioGridi124713. 6 interactions.
IntActiQ9BV29. 4 interactions.
STRINGi9606.ENSP00000452773.

Structurei

3D structure databases

ProteinModelPortaliQ9BV29.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

eggNOGiENOG410IWBU. Eukaryota.
ENOG41124NX. LUCA.
GeneTreeiENSGT00390000014780.
HOGENOMiHOG000111860.
HOVERGENiHBG054261.
InParanoidiQ9BV29.
PhylomeDBiQ9BV29.
TreeFamiTF332102.

Family and domain databases

InterProiIPR028039. CCDC32.
[Graphical view]
PfamiPF14989. CCDC32. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9BV29-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MKMFESADST ATRSGQDLWA EICSCLPNPE QEDGANNAFS DSFVDSCPEG
60 70 80 90 100
EGQREVADFA VQPAVKPWAP LQDSEVYLAS LEKKLRRIKG LNQEVTSKDM
110 120 130 140 150
LRTLAQAKKE CWDRFLQEKL ASEFFVDGLD SDESTLEHFK RWLQPDKVAV
160 170 180
STEEVQYLIP PESQVEKPVA EDEPAAGDKP AAAEQ
Length:185
Mass (Da):20,656
Last modified:March 1, 2004 - v2
Checksum:i3965B8A4FBC06651
GO
Isoform 2 (identifier: Q9BV29-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MRGSGLRFQM

Note: No experimental confirmation available.
Show »
Length:194
Mass (Da):21,689
Checksum:i0EECCDFE2F6031C1
GO
Isoform 3 (identifier: Q9BV29-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     134-134: S → R
     135-185: Missing.

Note: No experimental confirmation available.
Show »
Length:134
Mass (Da):15,070
Checksum:i5E88B930877E0EBE
GO

Sequence cautioni

The sequence CAD89911.1 differs from that shown. Reason: Erroneous initiation. Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti2 – 21K → I.2 Publications
Corresponds to variant rs10152546 [ dbSNP | Ensembl ].
VAR_034743

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 11M → MRGSGLRFQM in isoform 2. 1 PublicationVSP_027485
Alternative sequencei134 – 1341S → R in isoform 3. 1 PublicationVSP_027486
Alternative sequencei135 – 18551Missing in isoform 3. 1 PublicationVSP_027487Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK092214 mRNA. Translation: BAC03831.1.
AK098781 mRNA. Translation: BAC05411.1.
AK293079 mRNA. Translation: BAF85768.1.
AL832032 mRNA. Translation: CAD89911.1. Different initiation.
CH471125 Genomic DNA. Translation: EAW92421.1.
BC001673 mRNA. Translation: AAH01673.2.
CCDSiCCDS10060.1. [Q9BV29-1]
CCDS42022.1. [Q9BV29-2]
CCDS73706.1. [Q9BV29-3]
RefSeqiNP_001074260.1. NM_001080791.2. [Q9BV29-2]
NP_001074261.1. NM_001080792.2. [Q9BV29-1]
NP_001276061.1. NM_001289132.1. [Q9BV29-3]
NP_443081.1. NM_052849.3. [Q9BV29-1]
UniGeneiHs.654661.

Genome annotation databases

EnsembliENST00000358005; ENSP00000350695; ENSG00000128891. [Q9BV29-1]
ENST00000416810; ENSP00000397515; ENSG00000128891. [Q9BV29-1]
ENST00000558750; ENSP00000452773; ENSG00000128891. [Q9BV29-2]
ENST00000558871; ENSP00000452657; ENSG00000128891. [Q9BV29-3]
ENST00000559153; ENSP00000453607; ENSG00000128891. [Q9BV29-1]
ENST00000559291; ENSP00000453226; ENSG00000128891. [Q9BV29-1]
ENST00000561011; ENSP00000454049; ENSG00000128891. [Q9BV29-3]
GeneIDi90416.
KEGGihsa:90416.
UCSCiuc001zma.3. human. [Q9BV29-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK092214 mRNA. Translation: BAC03831.1.
AK098781 mRNA. Translation: BAC05411.1.
AK293079 mRNA. Translation: BAF85768.1.
AL832032 mRNA. Translation: CAD89911.1. Different initiation.
CH471125 Genomic DNA. Translation: EAW92421.1.
BC001673 mRNA. Translation: AAH01673.2.
CCDSiCCDS10060.1. [Q9BV29-1]
CCDS42022.1. [Q9BV29-2]
CCDS73706.1. [Q9BV29-3]
RefSeqiNP_001074260.1. NM_001080791.2. [Q9BV29-2]
NP_001074261.1. NM_001080792.2. [Q9BV29-1]
NP_001276061.1. NM_001289132.1. [Q9BV29-3]
NP_443081.1. NM_052849.3. [Q9BV29-1]
UniGeneiHs.654661.

3D structure databases

ProteinModelPortaliQ9BV29.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi124713. 6 interactions.
IntActiQ9BV29. 4 interactions.
STRINGi9606.ENSP00000452773.

PTM databases

iPTMnetiQ9BV29.
PhosphoSiteiQ9BV29.

Polymorphism and mutation databases

BioMutaiC15orf57.
DMDMi74733283.

Proteomic databases

EPDiQ9BV29.
MaxQBiQ9BV29.
PaxDbiQ9BV29.
PRIDEiQ9BV29.

Protocols and materials databases

DNASUi90416.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000358005; ENSP00000350695; ENSG00000128891. [Q9BV29-1]
ENST00000416810; ENSP00000397515; ENSG00000128891. [Q9BV29-1]
ENST00000558750; ENSP00000452773; ENSG00000128891. [Q9BV29-2]
ENST00000558871; ENSP00000452657; ENSG00000128891. [Q9BV29-3]
ENST00000559153; ENSP00000453607; ENSG00000128891. [Q9BV29-1]
ENST00000559291; ENSP00000453226; ENSG00000128891. [Q9BV29-1]
ENST00000561011; ENSP00000454049; ENSG00000128891. [Q9BV29-3]
GeneIDi90416.
KEGGihsa:90416.
UCSCiuc001zma.3. human. [Q9BV29-1]

Organism-specific databases

CTDi90416.
GeneCardsiC15orf57.
HGNCiHGNC:28295. C15orf57.
HPAiHPA041688.
neXtProtiNX_Q9BV29.
PharmGKBiPA162378234.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IWBU. Eukaryota.
ENOG41124NX. LUCA.
GeneTreeiENSGT00390000014780.
HOGENOMiHOG000111860.
HOVERGENiHBG054261.
InParanoidiQ9BV29.
PhylomeDBiQ9BV29.
TreeFamiTF332102.

Miscellaneous databases

ChiTaRSiC15orf57. human.
GenomeRNAii90416.
PROiQ9BV29.

Gene expression databases

BgeeiQ9BV29.
CleanExiHS_C15orf57.
ExpressionAtlasiQ9BV29. baseline and differential.
GenevisibleiQ9BV29. HS.

Family and domain databases

InterProiIPR028039. CCDC32.
[Graphical view]
PfamiPF14989. CCDC32. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 3), VARIANT ILE-2.
    Tissue: Brain and Uterus.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT ILE-2.
    Tissue: Skeletal muscle.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Lung.
  5. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiCO057_HUMAN
AccessioniPrimary (citable) accession number: Q9BV29
Secondary accession number(s): A8KAL4
, Q86TC4, Q8N788, Q8NAR7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 11, 2007
Last sequence update: March 1, 2004
Last modified: June 8, 2016
This is version 97 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 15
    Human chromosome 15: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.