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Protein

Tubulin beta chain

Gene

TUBB3

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

LigandGTP-bindingUniRule annotationSAAS annotation, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Tubulin beta chainUniRule annotation
Gene namesi
Name:TUBB3Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

MicrotubuleUniRule annotationSAAS annotation

PTM / Processingi

Proteomic databases

PaxDbiQ9BV28.
PeptideAtlasiQ9BV28.
PRIDEiQ9BV28.

Interactioni

Subunit structurei

Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.UniRule annotation

Protein-protein interaction databases

MINTiMINT-1382982.

Structurei

3D structure databases

ProteinModelPortaliQ9BV28.
SMRiQ9BV28.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini3 – 200TubulinInterPro annotationAdd BLAST198
Domaini202 – 339Tubulin_CInterPro annotationAdd BLAST138

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili364 – 391Sequence analysisAdd BLAST28

Sequence similaritiesi

Belongs to the tubulin family.UniRule annotationSAAS annotation

Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

eggNOGiKOG1375. Eukaryota.
COG5023. LUCA.
HOGENOMiHOG000169083.
HOVERGENiHBG000089.

Family and domain databases

Gene3Di3.30.1330.20. 1 hit.
3.40.50.1440. 1 hit.
InterProiView protein in InterPro
IPR002453. Beta_tubulin.
IPR008280. Tub_FtsZ_C.
IPR000217. Tubulin.
IPR018316. Tubulin/FtsZ_2-layer-sand-dom.
IPR017975. Tubulin_CS.
IPR003008. Tubulin_FtsZ_GTPase.
PANTHERiPTHR11588. PTHR11588. 1 hit.
PfamiView protein in Pfam
PF00091. Tubulin. 1 hit.
PF03953. Tubulin_C. 1 hit.
PRINTSiPR01163. BETATUBULIN.
PR01161. TUBULIN.
SMARTiView protein in SMART
SM00864. Tubulin. 1 hit.
SM00865. Tubulin_C. 1 hit.
SUPFAMiSSF52490. SSF52490. 1 hit.
SSF55307. SSF55307. 1 hit.
PROSITEiView protein in PROSITE
PS00227. TUBULIN. 1 hit.

Sequencei

Sequence statusi: Fragment.

Q9BV28-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
ERISVYYNEA SSHKYVPRAI LVDLEPGTMD SVRSGAFGHL FRPDNFIFGQ
60 70 80 90 100
SGAGNNWAKG HYTEGAELVD SVLDVVRKEC ENCDCLQGFQ LTHSLGGGTG
110 120 130 140 150
SGMGTLLISK VREEYPDRIM NTFSVVPSPK VSDTVVEPYN ATLSIHQLVE
160 170 180 190 200
NTDETYCIDN EALYDICFRT LKLATPTYGD LNHLVSATMS GVTTSLRFPG
210 220 230 240 250
QLNADLRKLA VNMVPFPRLH FFMPGFAPLT ARGSQQYRAL TVPELTQQMF
260 270 280 290 300
DAKNMMAACD PRHGRYLTVA TVFRGRMSMK EVDEQMLAIQ SKNSSYFVEW
310 320 330 340 350
IPNNVKVAVC DIPPRGLKMS STFIGNSTAI QELFKRISEQ FTAMFRRKAF
360 370 380 390 400
LHWYTGEGMD EMEFTEAESN MNDLVSEYQQ YQDATAEEEG EMYEDDEEES

EAQGPK
Length:406
Mass (Da):45,622
Last modified:March 1, 2004 - v2
Checksum:i8FF1A0A6CD88635E
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei1Imported1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC001678 mRNA. Translation: AAH01678.2.
UniGeneiHs.511743.

Similar proteinsi

Entry informationi

Entry nameiQ9BV28_HUMAN
AccessioniPrimary (citable) accession number: Q9BV28
Entry historyiIntegrated into UniProtKB/TrEMBL: June 1, 2001
Last sequence update: March 1, 2004
Last modified: August 30, 2017
This is version 117 of the entry and version 2 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.