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Q9BV23

- ABHD6_HUMAN

UniProt

Q9BV23 - ABHD6_HUMAN

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Protein

Monoacylglycerol lipase ABHD6

Gene
ABHD6
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Has 2-arachidonoylglycerol hydrolase activity By similarity. May be a regulator of endocannabinoid signaling pathways By similarity.

Catalytic activityi

Hydrolyzes glycerol monoesters of long-chain fatty acids.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei148 – 1481Charge relay system By similarity
Active sitei278 – 2781Charge relay system By similarity
Active sitei306 – 3061Charge relay system By similarity

GO - Molecular functioni

  1. acylglycerol lipase activity Source: UniProtKB-EC

GO - Biological processi

  1. long term synaptic depression Source: Ensembl
  2. negative regulation of cell migration Source: Ensembl
  3. regulation of endocannabinoid signaling pathway Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Protein family/group databases

MEROPSiS33.977.

Names & Taxonomyi

Protein namesi
Recommended name:
Monoacylglycerol lipase ABHD6 (EC:3.1.1.23)
Alternative name(s):
2-arachidonoylglycerol hydrolase
Abhydrolase domain-containing protein 6
Gene namesi
Name:ABHD6
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 3

Organism-specific databases

HGNCiHGNC:21398. ABHD6.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 88Extracellular Reviewed prediction
Transmembranei9 – 2921Helical; Signal-anchor for type II membrane protein; Reviewed predictionAdd
BLAST
Topological domaini30 – 337308Cytoplasmic Reviewed predictionAdd
BLAST

GO - Cellular componenti

  1. alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid selective glutamate receptor complex Source: Ensembl
  2. extracellular vesicular exosome Source: UniProt
  3. mitochondrion Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134916787.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 337337Monoacylglycerol lipase ABHD6PRO_0000281575Add
BLAST

Proteomic databases

MaxQBiQ9BV23.
PaxDbiQ9BV23.
PRIDEiQ9BV23.

PTM databases

PhosphoSiteiQ9BV23.

Expressioni

Gene expression databases

ArrayExpressiQ9BV23.
BgeeiQ9BV23.
CleanExiHS_ABHD6.
GenevestigatoriQ9BV23.

Organism-specific databases

HPAiHPA017283.

Interactioni

Protein-protein interaction databases

BioGridi121508. 3 interactions.
IntActiQ9BV23. 2 interactions.
STRINGi9606.ENSP00000295962.

Structurei

3D structure databases

ProteinModelPortaliQ9BV23.
SMRiQ9BV23. Positions 43-327.

Family & Domainsi

Sequence similaritiesi

Belongs to the AB hydrolase superfamily.

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG0596.
HOGENOMiHOG000008016.
HOVERGENiHBG059524.
InParanoidiQ9BV23.
KOiK13700.
OMAiNSFYRKL.
OrthoDBiEOG786H3D.
PhylomeDBiQ9BV23.
TreeFamiTF331946.

Family and domain databases

Gene3Di3.40.50.1820. 1 hit.
InterProiIPR029058. AB_hydrolase.
IPR000073. AB_hydrolase_1.
IPR000639. Epox_hydrolase-like.
[Graphical view]
PRINTSiPR00111. ABHYDROLASE.
PR00412. EPOXHYDRLASE.
SUPFAMiSSF53474. SSF53474. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9BV23-1 [UniParc]FASTAAdd to Basket

« Hide

MDLDVVNMFV IAGGTLAIPI LAFVASFLLW PSALIRIYYW YWRRTLGMQV    50
RYVHHEDYQF CYSFRGRPGH KPSILMLHGF SAHKDMWLSV VKFLPKNLHL 100
VCVDMPGHEG TTRSSLDDLS IDGQVKRIHQ FVECLKLNKK PFHLVGTSMG 150
GQVAGVYAAY YPSDVSSLCL VCPAGLQYST DNQFVQRLKE LQGSAAVEKI 200
PLIPSTPEEM SEMLQLCSYV RFKVPQQILQ GLVDVRIPHN NFYRKLFLEI 250
VSEKSRYSLH QNMDKIKVPT QIIWGKQDQV LDVSGADMLA KSIANCQVEL 300
LENCGHSVVM ERPRKTAKLI IDFLASVHNT DNNKKLD 337
Length:337
Mass (Da):38,331
Last modified:June 1, 2001 - v1
Checksum:iD87CEE8316F94910
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti11 – 111I → T in BAD18771. 1 Publication
Sequence conflicti135 – 1351L → P in BAD18771. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK122983 mRNA. Translation: BAG53832.1.
AK172797 mRNA. Translation: BAD18771.1.
AK313168 mRNA. Translation: BAG35986.1.
AC098479 Genomic DNA. No translation available.
AC137936 Genomic DNA. No translation available.
CH471055 Genomic DNA. Translation: EAW65360.1.
BC001698 mRNA. Translation: AAH01698.1.
CCDSiCCDS2887.1.
RefSeqiNP_065727.4. NM_020676.5.
XP_005265393.1. XM_005265336.2.
UniGeneiHs.476454.

Genome annotation databases

EnsembliENST00000295962; ENSP00000295962; ENSG00000163686.
ENST00000478253; ENSP00000420315; ENSG00000163686.
GeneIDi57406.
KEGGihsa:57406.
UCSCiuc003djs.4. human.

Polymorphism databases

DMDMi74733280.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK122983 mRNA. Translation: BAG53832.1 .
AK172797 mRNA. Translation: BAD18771.1 .
AK313168 mRNA. Translation: BAG35986.1 .
AC098479 Genomic DNA. No translation available.
AC137936 Genomic DNA. No translation available.
CH471055 Genomic DNA. Translation: EAW65360.1 .
BC001698 mRNA. Translation: AAH01698.1 .
CCDSi CCDS2887.1.
RefSeqi NP_065727.4. NM_020676.5.
XP_005265393.1. XM_005265336.2.
UniGenei Hs.476454.

3D structure databases

ProteinModelPortali Q9BV23.
SMRi Q9BV23. Positions 43-327.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 121508. 3 interactions.
IntActi Q9BV23. 2 interactions.
STRINGi 9606.ENSP00000295962.

Chemistry

ChEMBLi CHEMBL2189127.

Protein family/group databases

MEROPSi S33.977.

PTM databases

PhosphoSitei Q9BV23.

Polymorphism databases

DMDMi 74733280.

Proteomic databases

MaxQBi Q9BV23.
PaxDbi Q9BV23.
PRIDEi Q9BV23.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000295962 ; ENSP00000295962 ; ENSG00000163686 .
ENST00000478253 ; ENSP00000420315 ; ENSG00000163686 .
GeneIDi 57406.
KEGGi hsa:57406.
UCSCi uc003djs.4. human.

Organism-specific databases

CTDi 57406.
GeneCardsi GC03P058198.
HGNCi HGNC:21398. ABHD6.
HPAi HPA017283.
neXtProti NX_Q9BV23.
PharmGKBi PA134916787.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG0596.
HOGENOMi HOG000008016.
HOVERGENi HBG059524.
InParanoidi Q9BV23.
KOi K13700.
OMAi NSFYRKL.
OrthoDBi EOG786H3D.
PhylomeDBi Q9BV23.
TreeFami TF331946.

Miscellaneous databases

ChiTaRSi ABHD6. human.
GenomeRNAii 57406.
NextBioi 63520.
PROi Q9BV23.

Gene expression databases

ArrayExpressi Q9BV23.
Bgeei Q9BV23.
CleanExi HS_ABHD6.
Genevestigatori Q9BV23.

Family and domain databases

Gene3Di 3.40.50.1820. 1 hit.
InterProi IPR029058. AB_hydrolase.
IPR000073. AB_hydrolase_1.
IPR000639. Epox_hydrolase-like.
[Graphical view ]
PRINTSi PR00111. ABHYDROLASE.
PR00412. EPOXHYDRLASE.
SUPFAMi SSF53474. SSF53474. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Cerebellum, Hepatoma and Lung.
  2. "The DNA sequence, annotation and analysis of human chromosome 3."
    Muzny D.M., Scherer S.E., Kaul R., Wang J., Yu J., Sudbrak R., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J.
    , Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R., Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Wei S., Wheeler D.A., Wright M.W., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clendenning J., Clerc-Blankenburg K.P., Chen R., Chen Z., Davis C., Delgado O., Dinh H.H., Dong W., Draper H., Ernst S., Fu G., Gonzalez-Garay M.L., Garcia D.K., Gillett W., Gu J., Hao B., Haugen E., Havlak P., He X., Hennig S., Hu S., Huang W., Jackson L.R., Jacob L.S., Kelly S.H., Kube M., Levy R., Li Z., Liu B., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Palmeiri A., Pasternak S., Perez L.M., Phelps K.A., Plopper F.J., Qiang B., Raymond C., Rodriguez R., Saenphimmachak C., Santibanez J., Shen H., Shen Y., Subramanian S., Tabor P.E., Verduzco D., Waldron L., Wang J., Wang J., Wang Q., Williams G.A., Wong G.K.-S., Yao Z., Zhang J., Zhang X., Zhao G., Zhou J., Zhou Y., Nelson D., Lehrach H., Reinhardt R., Naylor S.L., Yang H., Olson M., Weinstock G., Gibbs R.A.
    Nature 440:1194-1198(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Skin.

Entry informationi

Entry nameiABHD6_HUMAN
AccessioniPrimary (citable) accession number: Q9BV23
Secondary accession number(s): B2R7Y9, Q6ZMF7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 20, 2007
Last sequence update: June 1, 2001
Last modified: September 3, 2014
This is version 96 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi