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Protein

Monoacylglycerol lipase ABHD6

Gene

ABHD6

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Lipase that preferentially hydrolysis medium-chain saturated monoacylglycerols including 2-arachidonoylglycerol (PubMed:22969151). Through 2-arachidonoylglycerol degradation may regulate endocannabinoid signaling pathways. May also have a lysophosphatidyl lipase activity with a preference for lysophosphatidylglycerol among other lysophospholipids (By similarity).By similarity1 Publication

Catalytic activityi

Hydrolyzes glycerol monoesters of long-chain fatty acids.1 Publication

Kineticsi

  1. KM=159 µM for 2-arachidonoyglycerol1 Publication
  1. Vmax=45 nmol/min/mg enzyme toward 2-arachidonoyglycerol1 Publication

pH dependencei

Optimum pH is 7.2-9 with 2-arachidonoyglycerol as substrate.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei148NucleophileBy similarity1 Publication1
Active sitei278Charge relay systemBy similarity1
Active sitei306Charge relay systemBy similarity1

GO - Molecular functioni

  • acylglycerol lipase activity Source: UniProtKB
  • phospholipase activity Source: GO_Central

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Enzyme and pathway databases

BioCyciZFISH:HS08913-MONOMER.
ReactomeiR-HSA-426048. Arachidonate production from DAG.

Protein family/group databases

ESTHERihuman-ABHD6. ABHD6-Lip.
MEROPSiS33.977.

Chemistry databases

SwissLipidsiSLP:000001042.

Names & Taxonomyi

Protein namesi
Recommended name:
Monoacylglycerol lipase ABHD6Curated (EC:3.1.1.231 Publication)
Alternative name(s):
2-arachidonoylglycerol hydrolaseBy similarity
Abhydrolase domain-containing protein 6Imported
Gene namesi
Name:ABHD6Imported
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

HGNCiHGNC:21398. ABHD6.

Subcellular locationi

  • Membrane By similarity; Single-pass type II membrane protein Sequence analysis
  • Mitochondrion By similarity

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 8ExtracellularSequence analysis8
Transmembranei9 – 29Helical; Signal-anchor for type II membrane proteinSequence analysisAdd BLAST21
Topological domaini30 – 337CytoplasmicSequence analysisAdd BLAST308

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi148S → A: Loss of 2-arachidonoyglycerol hydrolase activity. 1 Publication1

Organism-specific databases

DisGeNETi57406.
OpenTargetsiENSG00000163686.
PharmGKBiPA134916787.

Chemistry databases

ChEMBLiCHEMBL2189127.

Polymorphism and mutation databases

BioMutaiABHD6.
DMDMi74733280.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002815751 – 337Monoacylglycerol lipase ABHD6Add BLAST337

Proteomic databases

EPDiQ9BV23.
MaxQBiQ9BV23.
PaxDbiQ9BV23.
PeptideAtlasiQ9BV23.
PRIDEiQ9BV23.

PTM databases

iPTMnetiQ9BV23.
PhosphoSitePlusiQ9BV23.

Expressioni

Gene expression databases

BgeeiENSG00000163686.
CleanExiHS_ABHD6.
ExpressionAtlasiQ9BV23. baseline and differential.
GenevisibleiQ9BV23. HS.

Organism-specific databases

HPAiHPA017283.

Interactioni

Protein-protein interaction databases

BioGridi121508. 7 interactors.
IntActiQ9BV23. 3 interactors.
STRINGi9606.ENSP00000295962.

Chemistry databases

BindingDBiQ9BV23.

Structurei

3D structure databases

ProteinModelPortaliQ9BV23.
SMRiQ9BV23.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini72 – 313AB hydrolase-1Sequence analysisAdd BLAST242

Sequence similaritiesi

Belongs to the AB hydrolase superfamily.Curated

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IPFK. Eukaryota.
ENOG410XZ30. LUCA.
GeneTreeiENSGT00510000047225.
HOGENOMiHOG000008016.
HOVERGENiHBG059524.
InParanoidiQ9BV23.
KOiK13700.
OMAiDMWLSIV.
OrthoDBiEOG091G0AHA.
PhylomeDBiQ9BV23.
TreeFamiTF331946.

Family and domain databases

Gene3Di3.40.50.1820. 1 hit.
InterProiIPR029058. AB_hydrolase.
IPR000073. AB_hydrolase_1.
IPR000639. Epox_hydrolase-like.
[Graphical view]
PfamiPF00561. Abhydrolase_1. 1 hit.
[Graphical view]
PRINTSiPR00111. ABHYDROLASE.
PR00412. EPOXHYDRLASE.
SUPFAMiSSF53474. SSF53474. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9BV23-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDLDVVNMFV IAGGTLAIPI LAFVASFLLW PSALIRIYYW YWRRTLGMQV
60 70 80 90 100
RYVHHEDYQF CYSFRGRPGH KPSILMLHGF SAHKDMWLSV VKFLPKNLHL
110 120 130 140 150
VCVDMPGHEG TTRSSLDDLS IDGQVKRIHQ FVECLKLNKK PFHLVGTSMG
160 170 180 190 200
GQVAGVYAAY YPSDVSSLCL VCPAGLQYST DNQFVQRLKE LQGSAAVEKI
210 220 230 240 250
PLIPSTPEEM SEMLQLCSYV RFKVPQQILQ GLVDVRIPHN NFYRKLFLEI
260 270 280 290 300
VSEKSRYSLH QNMDKIKVPT QIIWGKQDQV LDVSGADMLA KSIANCQVEL
310 320 330
LENCGHSVVM ERPRKTAKLI IDFLASVHNT DNNKKLD
Length:337
Mass (Da):38,331
Last modified:June 1, 2001 - v1
Checksum:iD87CEE8316F94910
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti11I → T in BAD18771 (PubMed:14702039).Curated1
Sequence conflicti135L → P in BAD18771 (PubMed:14702039).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK122983 mRNA. Translation: BAG53832.1.
AK172797 mRNA. Translation: BAD18771.1.
AK313168 mRNA. Translation: BAG35986.1.
AC098479 Genomic DNA. No translation available.
AC137936 Genomic DNA. No translation available.
CH471055 Genomic DNA. Translation: EAW65360.1.
BC001698 mRNA. Translation: AAH01698.1.
CCDSiCCDS2887.1.
RefSeqiNP_001307055.1. NM_001320126.1.
NP_065727.4. NM_020676.6.
UniGeneiHs.476454.

Genome annotation databases

EnsembliENST00000295962; ENSP00000295962; ENSG00000163686.
ENST00000478253; ENSP00000420315; ENSG00000163686.
GeneIDi57406.
KEGGihsa:57406.
UCSCiuc003djs.4. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK122983 mRNA. Translation: BAG53832.1.
AK172797 mRNA. Translation: BAD18771.1.
AK313168 mRNA. Translation: BAG35986.1.
AC098479 Genomic DNA. No translation available.
AC137936 Genomic DNA. No translation available.
CH471055 Genomic DNA. Translation: EAW65360.1.
BC001698 mRNA. Translation: AAH01698.1.
CCDSiCCDS2887.1.
RefSeqiNP_001307055.1. NM_001320126.1.
NP_065727.4. NM_020676.6.
UniGeneiHs.476454.

3D structure databases

ProteinModelPortaliQ9BV23.
SMRiQ9BV23.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi121508. 7 interactors.
IntActiQ9BV23. 3 interactors.
STRINGi9606.ENSP00000295962.

Chemistry databases

BindingDBiQ9BV23.
ChEMBLiCHEMBL2189127.
SwissLipidsiSLP:000001042.

Protein family/group databases

ESTHERihuman-ABHD6. ABHD6-Lip.
MEROPSiS33.977.

PTM databases

iPTMnetiQ9BV23.
PhosphoSitePlusiQ9BV23.

Polymorphism and mutation databases

BioMutaiABHD6.
DMDMi74733280.

Proteomic databases

EPDiQ9BV23.
MaxQBiQ9BV23.
PaxDbiQ9BV23.
PeptideAtlasiQ9BV23.
PRIDEiQ9BV23.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000295962; ENSP00000295962; ENSG00000163686.
ENST00000478253; ENSP00000420315; ENSG00000163686.
GeneIDi57406.
KEGGihsa:57406.
UCSCiuc003djs.4. human.

Organism-specific databases

CTDi57406.
DisGeNETi57406.
GeneCardsiABHD6.
HGNCiHGNC:21398. ABHD6.
HPAiHPA017283.
neXtProtiNX_Q9BV23.
OpenTargetsiENSG00000163686.
PharmGKBiPA134916787.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IPFK. Eukaryota.
ENOG410XZ30. LUCA.
GeneTreeiENSGT00510000047225.
HOGENOMiHOG000008016.
HOVERGENiHBG059524.
InParanoidiQ9BV23.
KOiK13700.
OMAiDMWLSIV.
OrthoDBiEOG091G0AHA.
PhylomeDBiQ9BV23.
TreeFamiTF331946.

Enzyme and pathway databases

BioCyciZFISH:HS08913-MONOMER.
ReactomeiR-HSA-426048. Arachidonate production from DAG.

Miscellaneous databases

ChiTaRSiABHD6. human.
GenomeRNAii57406.
PROiQ9BV23.

Gene expression databases

BgeeiENSG00000163686.
CleanExiHS_ABHD6.
ExpressionAtlasiQ9BV23. baseline and differential.
GenevisibleiQ9BV23. HS.

Family and domain databases

Gene3Di3.40.50.1820. 1 hit.
InterProiIPR029058. AB_hydrolase.
IPR000073. AB_hydrolase_1.
IPR000639. Epox_hydrolase-like.
[Graphical view]
PfamiPF00561. Abhydrolase_1. 1 hit.
[Graphical view]
PRINTSiPR00111. ABHYDROLASE.
PR00412. EPOXHYDRLASE.
SUPFAMiSSF53474. SSF53474. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiABHD6_HUMAN
AccessioniPrimary (citable) accession number: Q9BV23
Secondary accession number(s): B2R7Y9, Q6ZMF7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 20, 2007
Last sequence update: June 1, 2001
Last modified: November 2, 2016
This is version 118 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.