Q9BV23 (ABHD6_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Monoacylglycerol lipase ABHD6
EC=3.1.1.23

Alternative name(s):
2-arachidonoylglycerol hydrolase
Abhydrolase domain-containing protein 6

Gene names

Name:

ABHD6

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	337 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Has 2-arachidonoylglycerol hydrolase activity By similarity. May be a regulator of endocannabinoid signaling pathways By similarity.
Catalytic activity	Hydrolyzes glycerol monoesters of long-chain fatty acids.
Subcellular location	Membrane; Single-pass type II membrane protein By similarity.
Sequence similarities	Belongs to the AB hydrolase superfamily.

Ontologies

Keywords
Cellular component	Membrane
Domain	Signal-anchor Transmembrane Transmembrane helix
Molecular function	Hydrolase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	long term synaptic depression Inferred from electronic annotation. Source: Compara metabolic process Inferred from electronic annotation. Source: GOC negative regulation of cell migration Inferred from electronic annotation. Source: Compara regulation of endocannabinoid signaling pathway Inferred from electronic annotation. Source: Compara
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW mitochondrion Inferred from electronic annotation. Source: Compara
Molecular_function	acylglycerol lipase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 337	337	Monoacylglycerol lipase ABHD6		PRO_0000281575
Regions
	Topological domain	1 – 8	8	Extracellular Potential
	Transmembrane	9 – 29	21	Helical; Signal-anchor for type II membrane protein; Potential
	Topological domain	30 – 337	308	Cytoplasmic Potential
Sites
	Active site	148	1	Charge relay system By similarity
	Active site	278	1	Charge relay system By similarity
	Active site	306	1	Charge relay system By similarity
Experimental info
	Sequence conflict	11	1	I → T in BAD18771. Ref.1
	Sequence conflict	135	1	L → P in BAD18771. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	Q9BV23 [UniParc]. Last modified June 1, 2001. Version 1. Checksum: D87CEE8316F94910	FASTA	337	38,331
	10 20 30 40 50 60 MDLDVVNMFV IAGGTLAIPI LAFVASFLLW PSALIRIYYW YWRRTLGMQV RYVHHEDYQF 70 80 90 100 110 120 CYSFRGRPGH KPSILMLHGF SAHKDMWLSV VKFLPKNLHL VCVDMPGHEG TTRSSLDDLS 130 140 150 160 170 180 IDGQVKRIHQ FVECLKLNKK PFHLVGTSMG GQVAGVYAAY YPSDVSSLCL VCPAGLQYST 190 200 210 220 230 240 DNQFVQRLKE LQGSAAVEKI PLIPSTPEEM SEMLQLCSYV RFKVPQQILQ GLVDVRIPHN 250 260 270 280 290 300 NFYRKLFLEI VSEKSRYSLH QNMDKIKVPT QIIWGKQDQV LDVSGADMLA KSIANCQVEL 310 320 330 LENCGHSVVM ERPRKTAKLI IDFLASVHNT DNNKKLD

References

[1]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Cerebellum, Hepatoma and Lung.
[2]	"The DNA sequence, annotation and analysis of human chromosome 3." Muzny D.M., Scherer S.E., Kaul R., Wang J., Yu J., Sudbrak R., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J. , Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R., Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Wei S., Wheeler D.A., Wright M.W., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clendenning J., Clerc-Blankenburg K.P., Chen R., Chen Z., Davis C., Delgado O., Dinh H.H., Dong W., Draper H., Ernst S., Fu G., Gonzalez-Garay M.L., Garcia D.K., Gillett W., Gu J., Hao B., Haugen E., Havlak P., He X., Hennig S., Hu S., Huang W., Jackson L.R., Jacob L.S., Kelly S.H., Kube M., Levy R., Li Z., Liu B., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Palmeiri A., Pasternak S., Perez L.M., Phelps K.A., Plopper F.J., Qiang B., Raymond C., Rodriguez R., Saenphimmachak C., Santibanez J., Shen H., Shen Y., Subramanian S., Tabor P.E., Verduzco D., Waldron L., Wang J., Wang J., Wang Q., Williams G.A., Wong G.K.-S., Yao Z., Zhang J., Zhang X., Zhao G., Zhou J., Zhou Y., Nelson D., Lehrach H., Reinhardt R., Naylor S.L., Yang H., Olson M., Weinstock G., Gibbs R.A. Nature 440:1194-1198(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Skin.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AK122983 mRNA. Translation: BAG53832.1. AK172797 mRNA. Translation: BAD18771.1. AK313168 mRNA. Translation: BAG35986.1. AC098479 Genomic DNA. No translation available. AC137936 Genomic DNA. No translation available. CH471055 Genomic DNA. Translation: EAW65360.1. BC001698 mRNA. Translation: AAH01698.1.
IPI	IPI00107039.
RefSeq	NP_065727.4. NM_020676.5.
UniGene	Hs.476454.
3D structure databases
ProteinModelPortal	Q9BV23.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q9BV23. 2 interactions.
STRING	9606.ENSP00000295962.
Protein family/group databases
MEROPS	S33.977.
PTM databases
PhosphoSite	Q9BV23.
Polymorphism databases
DMDM	74733280.
Proteomic databases
PaxDb	Q9BV23.
PRIDE	Q9BV23.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000295962; ENSP00000295962; ENSG00000163686. ENST00000478253; ENSP00000420315; ENSG00000163686.
GeneID	57406.
KEGG	hsa:57406.
UCSC	uc003djs.4. human.
Organism-specific databases
CTD	57406.
GeneCards	GC03P058198.
HGNC	HGNC:21398. ABHD6.
HPA	HPA017283.
neXtProt	NX_Q9BV23.
PharmGKB	PA134916787.
GenAtlas	Search...
Phylogenomic databases
eggNOG	COG0596.
HOGENOM	HOG000008016.
HOVERGEN	HBG059524.
InParanoid	Q9BV23.
KO	K13700.
OMA	ADCGGYR.
OrthoDB	EOG4MSCZH.
PhylomeDB	Q9BV23.
Gene expression databases
ArrayExpress	Q9BV23.
Bgee	Q9BV23.
CleanEx	HS_ABHD6.
Genevestigator	Q9BV23.
Family and domain databases
InterPro	IPR000073. AB_hydrolase_1. IPR000639. Epox_hydrolase-like. [Graphical view]
PRINTS	PR00111. ABHYDROLASE. PR00412. EPOXHYDRLASE.
ProtoNet	Search...
Other
ChiTaRS	ABHD6. human.
GenomeRNAi	57406.
NextBio	63520.

Entry information

Entry name

ABHD6_HUMAN

Accession

Primary (citable) accession number: Q9BV23
Secondary accession number(s): B2R7Y9, Q6ZMF7

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 20, 2007
Last sequence update:	June 1, 2001
Last modified:	May 1, 2013
This is version 84 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.