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Q9BV23

- ABHD6_HUMAN

UniProt

Q9BV23 - ABHD6_HUMAN

Protein

Monoacylglycerol lipase ABHD6

Gene

ABHD6

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 97 (01 Oct 2014)
      Sequence version 1 (01 Jun 2001)
      Previous versions | rss
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    Functioni

    Has 2-arachidonoylglycerol hydrolase activity. May be a regulator of endocannabinoid signaling pathways.By similarity

    Catalytic activityi

    Hydrolyzes glycerol monoesters of long-chain fatty acids.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei148 – 1481Charge relay systemBy similarity
    Active sitei278 – 2781Charge relay systemBy similarity
    Active sitei306 – 3061Charge relay systemBy similarity

    GO - Molecular functioni

    1. acylglycerol lipase activity Source: UniProtKB-EC

    GO - Biological processi

    1. long term synaptic depression Source: Ensembl
    2. negative regulation of cell migration Source: Ensembl
    3. regulation of endocannabinoid signaling pathway Source: Ensembl

    Keywords - Molecular functioni

    Hydrolase

    Protein family/group databases

    MEROPSiS33.977.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Monoacylglycerol lipase ABHD6 (EC:3.1.1.23)
    Alternative name(s):
    2-arachidonoylglycerol hydrolase
    Abhydrolase domain-containing protein 6
    Gene namesi
    Name:ABHD6
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 3

    Organism-specific databases

    HGNCiHGNC:21398. ABHD6.

    Subcellular locationi

    Membrane By similarity; Single-pass type II membrane protein By similarity

    GO - Cellular componenti

    1. alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid selective glutamate receptor complex Source: Ensembl
    2. extracellular vesicular exosome Source: UniProt
    3. mitochondrion Source: Ensembl

    Keywords - Cellular componenti

    Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA134916787.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 337337Monoacylglycerol lipase ABHD6PRO_0000281575Add
    BLAST

    Proteomic databases

    MaxQBiQ9BV23.
    PaxDbiQ9BV23.
    PRIDEiQ9BV23.

    PTM databases

    PhosphoSiteiQ9BV23.

    Expressioni

    Gene expression databases

    ArrayExpressiQ9BV23.
    BgeeiQ9BV23.
    CleanExiHS_ABHD6.
    GenevestigatoriQ9BV23.

    Organism-specific databases

    HPAiHPA017283.

    Interactioni

    Protein-protein interaction databases

    BioGridi121508. 3 interactions.
    IntActiQ9BV23. 2 interactions.
    STRINGi9606.ENSP00000295962.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9BV23.
    SMRiQ9BV23. Positions 43-327.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 88ExtracellularSequence Analysis
    Topological domaini30 – 337308CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei9 – 2921Helical; Signal-anchor for type II membrane proteinSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the AB hydrolase superfamily.Curated

    Keywords - Domaini

    Signal-anchor, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG0596.
    HOGENOMiHOG000008016.
    HOVERGENiHBG059524.
    InParanoidiQ9BV23.
    KOiK13700.
    OMAiNSFYRKL.
    OrthoDBiEOG786H3D.
    PhylomeDBiQ9BV23.
    TreeFamiTF331946.

    Family and domain databases

    Gene3Di3.40.50.1820. 1 hit.
    InterProiIPR029058. AB_hydrolase.
    IPR000073. AB_hydrolase_1.
    IPR000639. Epox_hydrolase-like.
    [Graphical view]
    PRINTSiPR00111. ABHYDROLASE.
    PR00412. EPOXHYDRLASE.
    SUPFAMiSSF53474. SSF53474. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q9BV23-1 [UniParc]FASTAAdd to Basket

    « Hide

    MDLDVVNMFV IAGGTLAIPI LAFVASFLLW PSALIRIYYW YWRRTLGMQV    50
    RYVHHEDYQF CYSFRGRPGH KPSILMLHGF SAHKDMWLSV VKFLPKNLHL 100
    VCVDMPGHEG TTRSSLDDLS IDGQVKRIHQ FVECLKLNKK PFHLVGTSMG 150
    GQVAGVYAAY YPSDVSSLCL VCPAGLQYST DNQFVQRLKE LQGSAAVEKI 200
    PLIPSTPEEM SEMLQLCSYV RFKVPQQILQ GLVDVRIPHN NFYRKLFLEI 250
    VSEKSRYSLH QNMDKIKVPT QIIWGKQDQV LDVSGADMLA KSIANCQVEL 300
    LENCGHSVVM ERPRKTAKLI IDFLASVHNT DNNKKLD 337
    Length:337
    Mass (Da):38,331
    Last modified:June 1, 2001 - v1
    Checksum:iD87CEE8316F94910
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti11 – 111I → T in BAD18771. (PubMed:14702039)Curated
    Sequence conflicti135 – 1351L → P in BAD18771. (PubMed:14702039)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK122983 mRNA. Translation: BAG53832.1.
    AK172797 mRNA. Translation: BAD18771.1.
    AK313168 mRNA. Translation: BAG35986.1.
    AC098479 Genomic DNA. No translation available.
    AC137936 Genomic DNA. No translation available.
    CH471055 Genomic DNA. Translation: EAW65360.1.
    BC001698 mRNA. Translation: AAH01698.1.
    CCDSiCCDS2887.1.
    RefSeqiNP_065727.4. NM_020676.5.
    XP_005265393.1. XM_005265336.2.
    UniGeneiHs.476454.

    Genome annotation databases

    EnsembliENST00000295962; ENSP00000295962; ENSG00000163686.
    ENST00000478253; ENSP00000420315; ENSG00000163686.
    GeneIDi57406.
    KEGGihsa:57406.
    UCSCiuc003djs.4. human.

    Polymorphism databases

    DMDMi74733280.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK122983 mRNA. Translation: BAG53832.1 .
    AK172797 mRNA. Translation: BAD18771.1 .
    AK313168 mRNA. Translation: BAG35986.1 .
    AC098479 Genomic DNA. No translation available.
    AC137936 Genomic DNA. No translation available.
    CH471055 Genomic DNA. Translation: EAW65360.1 .
    BC001698 mRNA. Translation: AAH01698.1 .
    CCDSi CCDS2887.1.
    RefSeqi NP_065727.4. NM_020676.5.
    XP_005265393.1. XM_005265336.2.
    UniGenei Hs.476454.

    3D structure databases

    ProteinModelPortali Q9BV23.
    SMRi Q9BV23. Positions 43-327.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 121508. 3 interactions.
    IntActi Q9BV23. 2 interactions.
    STRINGi 9606.ENSP00000295962.

    Chemistry

    ChEMBLi CHEMBL2189127.

    Protein family/group databases

    MEROPSi S33.977.

    PTM databases

    PhosphoSitei Q9BV23.

    Polymorphism databases

    DMDMi 74733280.

    Proteomic databases

    MaxQBi Q9BV23.
    PaxDbi Q9BV23.
    PRIDEi Q9BV23.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000295962 ; ENSP00000295962 ; ENSG00000163686 .
    ENST00000478253 ; ENSP00000420315 ; ENSG00000163686 .
    GeneIDi 57406.
    KEGGi hsa:57406.
    UCSCi uc003djs.4. human.

    Organism-specific databases

    CTDi 57406.
    GeneCardsi GC03P058198.
    HGNCi HGNC:21398. ABHD6.
    HPAi HPA017283.
    neXtProti NX_Q9BV23.
    PharmGKBi PA134916787.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG0596.
    HOGENOMi HOG000008016.
    HOVERGENi HBG059524.
    InParanoidi Q9BV23.
    KOi K13700.
    OMAi NSFYRKL.
    OrthoDBi EOG786H3D.
    PhylomeDBi Q9BV23.
    TreeFami TF331946.

    Miscellaneous databases

    ChiTaRSi ABHD6. human.
    GenomeRNAii 57406.
    NextBioi 63520.
    PROi Q9BV23.

    Gene expression databases

    ArrayExpressi Q9BV23.
    Bgeei Q9BV23.
    CleanExi HS_ABHD6.
    Genevestigatori Q9BV23.

    Family and domain databases

    Gene3Di 3.40.50.1820. 1 hit.
    InterProi IPR029058. AB_hydrolase.
    IPR000073. AB_hydrolase_1.
    IPR000639. Epox_hydrolase-like.
    [Graphical view ]
    PRINTSi PR00111. ABHYDROLASE.
    PR00412. EPOXHYDRLASE.
    SUPFAMi SSF53474. SSF53474. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Cerebellum, Hepatoma and Lung.
    2. "The DNA sequence, annotation and analysis of human chromosome 3."
      Muzny D.M., Scherer S.E., Kaul R., Wang J., Yu J., Sudbrak R., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J.
      , Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R., Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Wei S., Wheeler D.A., Wright M.W., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clendenning J., Clerc-Blankenburg K.P., Chen R., Chen Z., Davis C., Delgado O., Dinh H.H., Dong W., Draper H., Ernst S., Fu G., Gonzalez-Garay M.L., Garcia D.K., Gillett W., Gu J., Hao B., Haugen E., Havlak P., He X., Hennig S., Hu S., Huang W., Jackson L.R., Jacob L.S., Kelly S.H., Kube M., Levy R., Li Z., Liu B., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Palmeiri A., Pasternak S., Perez L.M., Phelps K.A., Plopper F.J., Qiang B., Raymond C., Rodriguez R., Saenphimmachak C., Santibanez J., Shen H., Shen Y., Subramanian S., Tabor P.E., Verduzco D., Waldron L., Wang J., Wang J., Wang Q., Williams G.A., Wong G.K.-S., Yao Z., Zhang J., Zhang X., Zhao G., Zhou J., Zhou Y., Nelson D., Lehrach H., Reinhardt R., Naylor S.L., Yang H., Olson M., Weinstock G., Gibbs R.A.
      Nature 440:1194-1198(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Skin.

    Entry informationi

    Entry nameiABHD6_HUMAN
    AccessioniPrimary (citable) accession number: Q9BV23
    Secondary accession number(s): B2R7Y9, Q6ZMF7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 20, 2007
    Last sequence update: June 1, 2001
    Last modified: October 1, 2014
    This is version 97 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 3
      Human chromosome 3: entries, gene names and cross-references to MIM
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3