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Q9BV20

- MTNA_HUMAN

UniProt

Q9BV20 - MTNA_HUMAN

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Protein

Methylthioribose-1-phosphate isomerase

Gene

MRI1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Catalyzes the interconversion of methylthioribose-1-phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P). Independently from catalytic activity, promotes cell invasion in response to constitutive RhoA activation by promoting FAK tyrosine phosphorylation and stress fiber turnover.1 PublicationUniRule annotation

Catalytic activityi

S-methyl-5-thio-alpha-D-ribose 1-phosphate = S-methyl-5-thio-D-ribulose 1-phosphate.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei168 – 1681Transition state stabilizer
Active sitei248 – 2481Proton donor1 PublicationUniRule annotation

GO - Molecular functioni

  1. identical protein binding Source: IntAct
  2. S-methyl-5-thioribose-1-phosphate isomerase activity Source: RefGenome

GO - Biological processi

  1. cellular nitrogen compound metabolic process Source: Reactome
  2. L-methionine biosynthetic process from methylthioadenosine Source: RefGenome
  3. L-methionine biosynthetic process from S-adenosylmethionine Source: UniProtKB-HAMAP
  4. polyamine metabolic process Source: Reactome
  5. small molecule metabolic process Source: Reactome
  6. sulfur amino acid metabolic process Source: Reactome
Complete GO annotation...

Keywords - Molecular functioni

Isomerase

Keywords - Biological processi

Amino-acid biosynthesis, Methionine biosynthesis

Enzyme and pathway databases

ReactomeiREACT_75881. Methionine salvage pathway.
UniPathwayiUPA00904; UER00874.

Names & Taxonomyi

Protein namesi
Recommended name:
Methylthioribose-1-phosphate isomeraseUniRule annotation (EC:5.3.1.23UniRule annotation)
Short name:
M1PiUniRule annotation
Short name:
MTR-1-P isomeraseUniRule annotation
Alternative name(s):
Mediator of RhoA-dependent invasion
S-methyl-5-thioribose-1-phosphate isomeraseUniRule annotation
Translation initiation factor eIF-2B subunit alpha/beta/delta-like proteinUniRule annotation
Gene namesi
Name:MRI1UniRule annotation
Synonyms:MRDI
ORF Names:UNQ6390/PRO21135
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 19

Organism-specific databases

HGNCiHGNC:28469. MRI1.

Subcellular locationi

Nucleus 1 PublicationUniRule annotation. Cytoplasm 1 PublicationUniRule annotation. Cell projection 1 Publication
Note: Primarily nuclear, but cytoplasmic in cancer cells, with enrichment at leading edge of the plasma membrane in late stage tumor cells.

GO - Cellular componenti

  1. cell projection Source: UniProtKB-KW
  2. cytoplasm Source: HPA
  3. cytosol Source: Reactome
  4. nucleolus Source: HPA
Complete GO annotation...

Keywords - Cellular componenti

Cell projection, Cytoplasm, Nucleus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi168 – 1681C → S: Abolishes enzymatic activity. 1 Publication
Mutagenesisi248 – 2481D → A: Abolishes enzymatic activity. 1 Publication

Organism-specific databases

PharmGKBiPA164723110.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 369369Methylthioribose-1-phosphate isomerasePRO_0000317325Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei1 – 11N-acetylmethionine1 Publication

Keywords - PTMi

Acetylation

Proteomic databases

MaxQBiQ9BV20.
PaxDbiQ9BV20.
PeptideAtlasiQ9BV20.
PRIDEiQ9BV20.

PTM databases

PhosphoSiteiQ9BV20.

Expressioni

Inductioni

By RhoA activation in cancer cells (at protein level).1 Publication

Gene expression databases

BgeeiQ9BV20.
ExpressionAtlasiQ9BV20. baseline and differential.
GenevestigatoriQ9BV20.

Organism-specific databases

HPAiCAB045988.
HPA042744.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
itself3EBI-747381,EBI-747381

Protein-protein interaction databases

BioGridi123973. 7 interactions.
IntActiQ9BV20. 1 interaction.
MINTiMINT-1197605.
STRINGi9606.ENSP00000040663.

Structurei

Secondary structure

1
369
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi5 – 95
Beta strandi12 – 165
Helixi18 – 203
Turni21 – 233
Beta strandi27 – 304
Helixi33 – 419
Helixi48 – 6316
Turni64 – 663
Beta strandi70 – 723
Helixi73 – 8715
Helixi95 – 11218
Helixi118 – 15538
Beta strandi162 – 1665
Turni172 – 1743
Beta strandi175 – 1784
Helixi181 – 19010
Beta strandi194 – 2007
Turni203 – 2064
Helixi207 – 2104
Helixi212 – 2187
Beta strandi223 – 2264
Helixi228 – 2303
Helixi231 – 2377
Beta strandi242 – 2454
Beta strandi248 – 2514
Beta strandi256 – 2594
Helixi262 – 27110
Beta strandi276 – 2794
Helixi282 – 2843
Helixi292 – 2943
Helixi303 – 3064
Beta strandi323 – 3286
Helixi330 – 3323
Beta strandi335 – 3395
Beta strandi342 – 3443
Helixi346 – 3483
Helixi349 – 3535

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4LDQX-ray2.50A/B1-369[»]
4LDRX-ray2.29A/B1-369[»]
ProteinModelPortaliQ9BV20.
SMRiQ9BV20. Positions 2-357.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the eIF-2B alpha/beta/delta subunits family. MtnA subfamily.UniRule annotation

Phylogenomic databases

eggNOGiCOG0182.
GeneTreeiENSGT00390000013732.
HOGENOMiHOG000224730.
InParanoidiQ9BV20.
KOiK08963.
OMAiAPGINCW.
OrthoDBiEOG7SBNP2.
PhylomeDBiQ9BV20.
TreeFamiTF300852.

Family and domain databases

Gene3Di1.20.120.420. 1 hit.
HAMAPiMF_01678. Salvage_MtnA.
InterProiIPR000649. IF-2B-related.
IPR005251. IF-M1Pi.
IPR011559. Initiation_fac_2B_a/b/d.
IPR027363. M1Pi_N.
[Graphical view]
PfamiPF01008. IF-2B. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00524. eIF-2B_rel. 1 hit.
TIGR00512. salvage_mtnA. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q9BV20-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MTLEAIRYSR GSLQILDQLL LPKQSRYEAV GSVHQAWEAI RAMKVRGAPA
60 70 80 90 100
IALVGCLSLA VELQAGAGGP GLAALVAFVR DKLSFLVTAR PTAVNMARAA
110 120 130 140 150
RDLADVAARE AEREGATEEA VRERVICCTE DMLEKDLRDN RSIGDLGARH
160 170 180 190 200
LLERVAPSGG KVTVLTHCNT GALATAGYGT ALGVIRSLHS LGRLEHAFCT
210 220 230 240 250
ETRPYNQGAR LTAFELVYEQ IPATLITDSM VAAAMAHRGV SAVVVGADRV
260 270 280 290 300
VANGDTANKV GTYQLAIVAK HHGIPFYVAA PSSSCDLRLE TGKEIIIEER
310 320 330 340 350
PGQELTDVNG VRIAAPGIGV WNPAFDVTPH DLITGGIITE LGVFAPEELR
360
TALTTTISSR DGTLDGPQM
Length:369
Mass (Da):39,150
Last modified:June 1, 2001 - v1
Checksum:iA6A1B5EC76632F4F
GO
Isoform 2 (identifier: Q9BV20-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     125-200: VICCTEDMLE...LGRLEHAFCT → RETELCEHWEEHTRQRELPLRGPLGGTVL

Show »
Length:322
Mass (Da):34,529
Checksum:iB9C6A0C26615AA76
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti235 – 2351M → V.
Corresponds to variant rs35098252 [ dbSNP | Ensembl ].
VAR_059253
Natural varianti319 – 3191G → A.
Corresponds to variant rs10402855 [ dbSNP | Ensembl ].
VAR_059254

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei125 – 20076VICCT…HAFCT → RETELCEHWEEHTRQRELPL RGPLGGTVL in isoform 2. 1 PublicationVSP_030935Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY358176 mRNA. Translation: AAQ88543.1.
AL834276 mRNA. Translation: CAD38951.1.
CH471106 Genomic DNA. Translation: EAW84370.1.
CH471106 Genomic DNA. Translation: EAW84371.1.
BC001703 mRNA. Translation: AAH01703.1.
CCDSiCCDS12297.1. [Q9BV20-2]
CCDS32923.1. [Q9BV20-1]
RefSeqiNP_001026897.1. NM_001031727.2. [Q9BV20-1]
NP_115661.1. NM_032285.2. [Q9BV20-2]
UniGeneiHs.439370.

Genome annotation databases

EnsembliENST00000040663; ENSP00000040663; ENSG00000037757. [Q9BV20-1]
ENST00000319545; ENSP00000314871; ENSG00000037757. [Q9BV20-2]
GeneIDi84245.
KEGGihsa:84245.
UCSCiuc002mxe.3. human. [Q9BV20-1]
uc002mxf.3. human. [Q9BV20-2]

Polymorphism databases

DMDMi74733279.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY358176 mRNA. Translation: AAQ88543.1 .
AL834276 mRNA. Translation: CAD38951.1 .
CH471106 Genomic DNA. Translation: EAW84370.1 .
CH471106 Genomic DNA. Translation: EAW84371.1 .
BC001703 mRNA. Translation: AAH01703.1 .
CCDSi CCDS12297.1. [Q9BV20-2 ]
CCDS32923.1. [Q9BV20-1 ]
RefSeqi NP_001026897.1. NM_001031727.2. [Q9BV20-1 ]
NP_115661.1. NM_032285.2. [Q9BV20-2 ]
UniGenei Hs.439370.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
4LDQ X-ray 2.50 A/B 1-369 [» ]
4LDR X-ray 2.29 A/B 1-369 [» ]
ProteinModelPortali Q9BV20.
SMRi Q9BV20. Positions 2-357.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 123973. 7 interactions.
IntActi Q9BV20. 1 interaction.
MINTi MINT-1197605.
STRINGi 9606.ENSP00000040663.

PTM databases

PhosphoSitei Q9BV20.

Polymorphism databases

DMDMi 74733279.

Proteomic databases

MaxQBi Q9BV20.
PaxDbi Q9BV20.
PeptideAtlasi Q9BV20.
PRIDEi Q9BV20.

Protocols and materials databases

DNASUi 84245.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000040663 ; ENSP00000040663 ; ENSG00000037757 . [Q9BV20-1 ]
ENST00000319545 ; ENSP00000314871 ; ENSG00000037757 . [Q9BV20-2 ]
GeneIDi 84245.
KEGGi hsa:84245.
UCSCi uc002mxe.3. human. [Q9BV20-1 ]
uc002mxf.3. human. [Q9BV20-2 ]

Organism-specific databases

CTDi 84245.
GeneCardsi GC19P013875.
HGNCi HGNC:28469. MRI1.
HPAi CAB045988.
HPA042744.
MIMi 615105. gene.
neXtProti NX_Q9BV20.
PharmGKBi PA164723110.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG0182.
GeneTreei ENSGT00390000013732.
HOGENOMi HOG000224730.
InParanoidi Q9BV20.
KOi K08963.
OMAi APGINCW.
OrthoDBi EOG7SBNP2.
PhylomeDBi Q9BV20.
TreeFami TF300852.

Enzyme and pathway databases

UniPathwayi UPA00904 ; UER00874 .
Reactomei REACT_75881. Methionine salvage pathway.

Miscellaneous databases

GeneWikii MGC3207.
GenomeRNAii 84245.
NextBioi 73721.
PROi Q9BV20.
SOURCEi Search...

Gene expression databases

Bgeei Q9BV20.
ExpressionAtlasi Q9BV20. baseline and differential.
Genevestigatori Q9BV20.

Family and domain databases

Gene3Di 1.20.120.420. 1 hit.
HAMAPi MF_01678. Salvage_MtnA.
InterProi IPR000649. IF-2B-related.
IPR005251. IF-M1Pi.
IPR011559. Initiation_fac_2B_a/b/d.
IPR027363. M1Pi_N.
[Graphical view ]
Pfami PF01008. IF-2B. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR00524. eIF-2B_rel. 1 hit.
TIGR00512. salvage_mtnA. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Brain.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Brain.
  5. Cited for: IDENTIFICATION BY MASS SPECTROMETRY, FUNCTION, ACTIVE SITE, INDUCTION BY RHOA, SUBCELLULAR LOCATION, MUTAGENESIS OF CYS-168 AND ASP-248.
  6. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  7. Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT MET-1, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiMTNA_HUMAN
AccessioniPrimary (citable) accession number: Q9BV20
Secondary accession number(s): Q8NDC9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: June 1, 2001
Last modified: October 29, 2014
This is version 111 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  6. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  7. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3