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Q9BV20

- MTNA_HUMAN

UniProt

Q9BV20 - MTNA_HUMAN

Protein

Methylthioribose-1-phosphate isomerase

Gene

MRI1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 110 (01 Oct 2014)
      Sequence version 1 (01 Jun 2001)
      Previous versions | rss
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    Functioni

    Catalyzes the interconversion of methylthioribose-1-phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P). Independently from catalytic activity, promotes cell invasion in response to constitutive RhoA activation by promoting FAK tyrosine phosphorylation and stress fiber turnover.1 PublicationUniRule annotation

    Catalytic activityi

    S-methyl-5-thio-alpha-D-ribose 1-phosphate = S-methyl-5-thio-D-ribulose 1-phosphate.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sitei168 – 1681Transition state stabilizer
    Active sitei248 – 2481Proton donor1 PublicationUniRule annotation

    GO - Molecular functioni

    1. identical protein binding Source: IntAct
    2. S-methyl-5-thioribose-1-phosphate isomerase activity Source: RefGenome

    GO - Biological processi

    1. cellular nitrogen compound metabolic process Source: Reactome
    2. L-methionine biosynthetic process from methylthioadenosine Source: RefGenome
    3. L-methionine biosynthetic process from S-adenosylmethionine Source: UniProtKB-HAMAP
    4. polyamine metabolic process Source: Reactome
    5. small molecule metabolic process Source: Reactome
    6. sulfur amino acid metabolic process Source: Reactome

    Keywords - Molecular functioni

    Isomerase

    Keywords - Biological processi

    Amino-acid biosynthesis, Methionine biosynthesis

    Enzyme and pathway databases

    ReactomeiREACT_75881. Methionine salvage pathway.
    UniPathwayiUPA00904; UER00874.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Methylthioribose-1-phosphate isomeraseUniRule annotation (EC:5.3.1.23UniRule annotation)
    Short name:
    M1PiUniRule annotation
    Short name:
    MTR-1-P isomeraseUniRule annotation
    Alternative name(s):
    Mediator of RhoA-dependent invasion
    S-methyl-5-thioribose-1-phosphate isomeraseUniRule annotation
    Translation initiation factor eIF-2B subunit alpha/beta/delta-like proteinUniRule annotation
    Gene namesi
    Name:MRI1UniRule annotation
    Synonyms:MRDI
    ORF Names:UNQ6390/PRO21135
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 19

    Organism-specific databases

    HGNCiHGNC:28469. MRI1.

    Subcellular locationi

    Nucleus 1 PublicationUniRule annotation. Cytoplasm 1 PublicationUniRule annotation. Cell projection 1 Publication
    Note: Primarily nuclear, but cytoplasmic in cancer cells, with enrichment at leading edge of the plasma membrane in late stage tumor cells.

    GO - Cellular componenti

    1. cell projection Source: UniProtKB-SubCell
    2. cytoplasm Source: HPA
    3. cytosol Source: Reactome
    4. nucleolus Source: HPA

    Keywords - Cellular componenti

    Cell projection, Cytoplasm, Nucleus

    Pathology & Biotechi

    Mutagenesis

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Mutagenesisi168 – 1681C → S: Abolishes enzymatic activity. 1 Publication
    Mutagenesisi248 – 2481D → A: Abolishes enzymatic activity. 1 Publication

    Organism-specific databases

    PharmGKBiPA164723110.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 369369Methylthioribose-1-phosphate isomerasePRO_0000317325Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei1 – 11N-acetylmethionine1 Publication

    Keywords - PTMi

    Acetylation

    Proteomic databases

    MaxQBiQ9BV20.
    PaxDbiQ9BV20.
    PeptideAtlasiQ9BV20.
    PRIDEiQ9BV20.

    PTM databases

    PhosphoSiteiQ9BV20.

    Expressioni

    Inductioni

    By RhoA activation in cancer cells (at protein level).1 Publication

    Gene expression databases

    ArrayExpressiQ9BV20.
    BgeeiQ9BV20.
    GenevestigatoriQ9BV20.

    Organism-specific databases

    HPAiCAB045988.
    HPA042744.

    Interactioni

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    itself3EBI-747381,EBI-747381

    Protein-protein interaction databases

    BioGridi123973. 6 interactions.
    IntActiQ9BV20. 1 interaction.
    MINTiMINT-1197605.
    STRINGi9606.ENSP00000040663.

    Structurei

    Secondary structure

    1
    369
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Beta strandi5 – 95
    Beta strandi12 – 165
    Helixi18 – 203
    Turni21 – 233
    Beta strandi27 – 304
    Helixi33 – 419
    Helixi48 – 6316
    Turni64 – 663
    Beta strandi70 – 723
    Helixi73 – 8715
    Helixi95 – 11218
    Helixi118 – 15538
    Beta strandi162 – 1665
    Turni172 – 1743
    Beta strandi175 – 1784
    Helixi181 – 19010
    Beta strandi194 – 2007
    Turni203 – 2064
    Helixi207 – 2104
    Helixi212 – 2187
    Beta strandi223 – 2264
    Helixi228 – 2303
    Helixi231 – 2377
    Beta strandi242 – 2454
    Beta strandi248 – 2514
    Beta strandi256 – 2594
    Helixi262 – 27110
    Beta strandi276 – 2794
    Helixi282 – 2843
    Helixi292 – 2943
    Helixi303 – 3064
    Beta strandi323 – 3286
    Helixi330 – 3323
    Beta strandi335 – 3395
    Beta strandi342 – 3443
    Helixi346 – 3483
    Helixi349 – 3535

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    4LDQX-ray2.50A/B1-369[»]
    4LDRX-ray2.29A/B1-369[»]
    ProteinModelPortaliQ9BV20.
    SMRiQ9BV20. Positions 2-357.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the eIF-2B alpha/beta/delta subunits family. MtnA subfamily.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0182.
    HOGENOMiHOG000224730.
    InParanoidiQ9BV20.
    KOiK08963.
    OMAiAPGINCW.
    OrthoDBiEOG7SBNP2.
    PhylomeDBiQ9BV20.
    TreeFamiTF300852.

    Family and domain databases

    Gene3Di1.20.120.420. 1 hit.
    HAMAPiMF_01678. Salvage_MtnA.
    InterProiIPR000649. IF-2B-related.
    IPR005251. IF-M1Pi.
    IPR011559. Initiation_fac_2B_a/b/d.
    IPR027363. M1Pi_N.
    [Graphical view]
    PfamiPF01008. IF-2B. 1 hit.
    [Graphical view]
    TIGRFAMsiTIGR00524. eIF-2B_rel. 1 hit.
    TIGR00512. salvage_mtnA. 1 hit.

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q9BV20-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MTLEAIRYSR GSLQILDQLL LPKQSRYEAV GSVHQAWEAI RAMKVRGAPA    50
    IALVGCLSLA VELQAGAGGP GLAALVAFVR DKLSFLVTAR PTAVNMARAA 100
    RDLADVAARE AEREGATEEA VRERVICCTE DMLEKDLRDN RSIGDLGARH 150
    LLERVAPSGG KVTVLTHCNT GALATAGYGT ALGVIRSLHS LGRLEHAFCT 200
    ETRPYNQGAR LTAFELVYEQ IPATLITDSM VAAAMAHRGV SAVVVGADRV 250
    VANGDTANKV GTYQLAIVAK HHGIPFYVAA PSSSCDLRLE TGKEIIIEER 300
    PGQELTDVNG VRIAAPGIGV WNPAFDVTPH DLITGGIITE LGVFAPEELR 350
    TALTTTISSR DGTLDGPQM 369
    Length:369
    Mass (Da):39,150
    Last modified:June 1, 2001 - v1
    Checksum:iA6A1B5EC76632F4F
    GO
    Isoform 2 (identifier: Q9BV20-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         125-200: VICCTEDMLE...LGRLEHAFCT → RETELCEHWEEHTRQRELPLRGPLGGTVL

    Show »
    Length:322
    Mass (Da):34,529
    Checksum:iB9C6A0C26615AA76
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti235 – 2351M → V.
    Corresponds to variant rs35098252 [ dbSNP | Ensembl ].
    VAR_059253
    Natural varianti319 – 3191G → A.
    Corresponds to variant rs10402855 [ dbSNP | Ensembl ].
    VAR_059254

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei125 – 20076VICCT…HAFCT → RETELCEHWEEHTRQRELPL RGPLGGTVL in isoform 2. 1 PublicationVSP_030935Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY358176 mRNA. Translation: AAQ88543.1.
    AL834276 mRNA. Translation: CAD38951.1.
    CH471106 Genomic DNA. Translation: EAW84370.1.
    CH471106 Genomic DNA. Translation: EAW84371.1.
    BC001703 mRNA. Translation: AAH01703.1.
    CCDSiCCDS12297.1. [Q9BV20-2]
    CCDS32923.1. [Q9BV20-1]
    RefSeqiNP_001026897.1. NM_001031727.2. [Q9BV20-1]
    NP_115661.1. NM_032285.2. [Q9BV20-2]
    UniGeneiHs.439370.

    Genome annotation databases

    EnsembliENST00000040663; ENSP00000040663; ENSG00000037757. [Q9BV20-1]
    ENST00000319545; ENSP00000314871; ENSG00000037757. [Q9BV20-2]
    GeneIDi84245.
    KEGGihsa:84245.
    UCSCiuc002mxe.3. human. [Q9BV20-1]
    uc002mxf.3. human. [Q9BV20-2]

    Polymorphism databases

    DMDMi74733279.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY358176 mRNA. Translation: AAQ88543.1 .
    AL834276 mRNA. Translation: CAD38951.1 .
    CH471106 Genomic DNA. Translation: EAW84370.1 .
    CH471106 Genomic DNA. Translation: EAW84371.1 .
    BC001703 mRNA. Translation: AAH01703.1 .
    CCDSi CCDS12297.1. [Q9BV20-2 ]
    CCDS32923.1. [Q9BV20-1 ]
    RefSeqi NP_001026897.1. NM_001031727.2. [Q9BV20-1 ]
    NP_115661.1. NM_032285.2. [Q9BV20-2 ]
    UniGenei Hs.439370.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    4LDQ X-ray 2.50 A/B 1-369 [» ]
    4LDR X-ray 2.29 A/B 1-369 [» ]
    ProteinModelPortali Q9BV20.
    SMRi Q9BV20. Positions 2-357.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 123973. 6 interactions.
    IntActi Q9BV20. 1 interaction.
    MINTi MINT-1197605.
    STRINGi 9606.ENSP00000040663.

    PTM databases

    PhosphoSitei Q9BV20.

    Polymorphism databases

    DMDMi 74733279.

    Proteomic databases

    MaxQBi Q9BV20.
    PaxDbi Q9BV20.
    PeptideAtlasi Q9BV20.
    PRIDEi Q9BV20.

    Protocols and materials databases

    DNASUi 84245.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000040663 ; ENSP00000040663 ; ENSG00000037757 . [Q9BV20-1 ]
    ENST00000319545 ; ENSP00000314871 ; ENSG00000037757 . [Q9BV20-2 ]
    GeneIDi 84245.
    KEGGi hsa:84245.
    UCSCi uc002mxe.3. human. [Q9BV20-1 ]
    uc002mxf.3. human. [Q9BV20-2 ]

    Organism-specific databases

    CTDi 84245.
    GeneCardsi GC19P013875.
    HGNCi HGNC:28469. MRI1.
    HPAi CAB045988.
    HPA042744.
    MIMi 615105. gene.
    neXtProti NX_Q9BV20.
    PharmGKBi PA164723110.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG0182.
    HOGENOMi HOG000224730.
    InParanoidi Q9BV20.
    KOi K08963.
    OMAi APGINCW.
    OrthoDBi EOG7SBNP2.
    PhylomeDBi Q9BV20.
    TreeFami TF300852.

    Enzyme and pathway databases

    UniPathwayi UPA00904 ; UER00874 .
    Reactomei REACT_75881. Methionine salvage pathway.

    Miscellaneous databases

    GeneWikii MGC3207.
    GenomeRNAii 84245.
    NextBioi 73721.
    PROi Q9BV20.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q9BV20.
    Bgeei Q9BV20.
    Genevestigatori Q9BV20.

    Family and domain databases

    Gene3Di 1.20.120.420. 1 hit.
    HAMAPi MF_01678. Salvage_MtnA.
    InterProi IPR000649. IF-2B-related.
    IPR005251. IF-M1Pi.
    IPR011559. Initiation_fac_2B_a/b/d.
    IPR027363. M1Pi_N.
    [Graphical view ]
    Pfami PF01008. IF-2B. 1 hit.
    [Graphical view ]
    TIGRFAMsi TIGR00524. eIF-2B_rel. 1 hit.
    TIGR00512. salvage_mtnA. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
      Tissue: Brain.
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Brain.
    5. Cited for: IDENTIFICATION BY MASS SPECTROMETRY, FUNCTION, ACTIVE SITE, INDUCTION BY RHOA, SUBCELLULAR LOCATION, MUTAGENESIS OF CYS-168 AND ASP-248.
    6. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    7. Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT MET-1, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiMTNA_HUMAN
    AccessioniPrimary (citable) accession number: Q9BV20
    Secondary accession number(s): Q8NDC9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 5, 2008
    Last sequence update: June 1, 2001
    Last modified: October 1, 2014
    This is version 110 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. Human chromosome 19
      Human chromosome 19: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    6. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    7. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3