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Protein

Uncharacterized protein C1orf50

Gene

C1orf50

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Uncharacterized protein C1orf50
Gene namesi
Name:C1orf50
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:28795. C1orf50.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134861089.

Polymorphism and mutation databases

BioMutaiC1orf50.
DMDMi223590163.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 199199Uncharacterized protein C1orf50PRO_0000251189Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei1 – 11N-acetylmethionine1 Publication

Keywords - PTMi

Acetylation

Proteomic databases

MaxQBiQ9BV19.
PaxDbiQ9BV19.
PRIDEiQ9BV19.

PTM databases

PhosphoSiteiQ9BV19.

Expressioni

Gene expression databases

BgeeiQ9BV19.
CleanExiHS_C1orf50.
ExpressionAtlasiQ9BV19. baseline and differential.
GenevisibleiQ9BV19. HS.

Organism-specific databases

HPAiHPA030236.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
AHCYP235263EBI-2874661,EBI-1053240
APPBP2Q926243EBI-2874661,EBI-743771
EPM2AIP1Q7L7753EBI-2874661,EBI-6255981
WDYHV1Q96HA83EBI-2874661,EBI-741158

Protein-protein interaction databases

BioGridi122528. 6 interactions.
IntActiQ9BV19. 5 interactions.
STRINGi9606.ENSP00000361603.

Structurei

3D structure databases

ProteinModelPortaliQ9BV19.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili71 – 10131Sequence AnalysisAdd
BLAST

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiNOG84695.
GeneTreeiENSGT00390000003084.
HOGENOMiHOG000230218.
HOVERGENiHBG080112.
InParanoidiQ9BV19.
OMAiCNIVKKP.
PhylomeDBiQ9BV19.
TreeFamiTF105992.

Family and domain databases

InterProiIPR019534. DUF2452.
[Graphical view]
PfamiPF10504. DUF2452. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9BV19-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEDAAAPGRT EGVLERQGAP PAAGQGGALV ELTPTPGGLA LVSPYHTHRA
60 70 80 90 100
GDPLDLVALA EQVQKADEFI RANATNKLTV IAEQIQHLQE QARKVLEDAH
110 120 130 140 150
RDANLHHVAC NIVKKPGNIY YLYKRESGQQ YFSIISPKEW GTSCPHDFLG
160 170 180 190
AYKLQHDLSW TPYEDIEKQD AKISMMDTLL SQSVALPPCT EPNFQGLTH
Length:199
Mass (Da):21,877
Last modified:February 10, 2009 - v2
Checksum:i499A0179C042E39D
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti178 – 1781T → M.1 Publication
Corresponds to variant rs11548275 [ dbSNP | Ensembl ].
VAR_054409

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC098484 Genomic DNA. No translation available.
BC001508 mRNA. Translation: AAH01508.1.
BC001711 mRNA. Translation: AAH01711.1.
CCDSiCCDS473.1.
RefSeqiNP_077002.2. NM_024097.3.
UniGeneiHs.148845.

Genome annotation databases

EnsembliENST00000372525; ENSP00000361603; ENSG00000164008.
GeneIDi79078.
KEGGihsa:79078.
UCSCiuc001cia.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC098484 Genomic DNA. No translation available.
BC001508 mRNA. Translation: AAH01508.1.
BC001711 mRNA. Translation: AAH01711.1.
CCDSiCCDS473.1.
RefSeqiNP_077002.2. NM_024097.3.
UniGeneiHs.148845.

3D structure databases

ProteinModelPortaliQ9BV19.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi122528. 6 interactions.
IntActiQ9BV19. 5 interactions.
STRINGi9606.ENSP00000361603.

PTM databases

PhosphoSiteiQ9BV19.

Polymorphism and mutation databases

BioMutaiC1orf50.
DMDMi223590163.

Proteomic databases

MaxQBiQ9BV19.
PaxDbiQ9BV19.
PRIDEiQ9BV19.

Protocols and materials databases

DNASUi79078.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000372525; ENSP00000361603; ENSG00000164008.
GeneIDi79078.
KEGGihsa:79078.
UCSCiuc001cia.4. human.

Organism-specific databases

CTDi79078.
GeneCardsiGC01P043232.
HGNCiHGNC:28795. C1orf50.
HPAiHPA030236.
neXtProtiNX_Q9BV19.
PharmGKBiPA134861089.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG84695.
GeneTreeiENSGT00390000003084.
HOGENOMiHOG000230218.
HOVERGENiHBG080112.
InParanoidiQ9BV19.
OMAiCNIVKKP.
PhylomeDBiQ9BV19.
TreeFamiTF105992.

Miscellaneous databases

ChiTaRSiC1orf50. human.
GenomeRNAii79078.
NextBioi67879.
PROiQ9BV19.

Gene expression databases

BgeeiQ9BV19.
CleanExiHS_C1orf50.
ExpressionAtlasiQ9BV19. baseline and differential.
GenevisibleiQ9BV19. HS.

Family and domain databases

InterProiIPR019534. DUF2452.
[Graphical view]
PfamiPF10504. DUF2452. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The DNA sequence and biological annotation of human chromosome 1."
    Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
    , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
    Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT MET-178.
    Tissue: Lymph.
  3. Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT MET-1, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiCA050_HUMAN
AccessioniPrimary (citable) accession number: Q9BV19
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 3, 2006
Last sequence update: February 10, 2009
Last modified: June 24, 2015
This is version 89 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.