UniProtKB - Q9BUY7 (EFC11_HUMAN)
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Protein
EF-hand calcium-binding domain-containing protein 11
Gene
EFCAB11
Organism
Homo sapiens (Human)
Status
Functioni
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Calcium bindingi | 140 – 151 | 1PROSITE-ProRule annotationAdd BLAST | 12 |
GO - Molecular functioni
- calcium ion binding Source: GO_Central
Keywordsi
Ligand | Calcium, Metal-binding |
Names & Taxonomyi
Protein namesi | Recommended name: EF-hand calcium-binding domain-containing protein 11 |
Gene namesi | Name:EFCAB11 Synonyms:C14orf143 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000140025.15. |
HGNCi | HGNC:20357. EFCAB11. |
neXtProti | NX_Q9BUY7. |
Pathology & Biotechi
Organism-specific databases
DisGeNETi | 90141. |
OpenTargetsi | ENSG00000140025. |
PharmGKBi | PA134875422. |
Polymorphism and mutation databases
BioMutai | EFCAB11. |
DMDMi | 74762709. |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000286580 | 1 – 163 | EF-hand calcium-binding domain-containing protein 11Add BLAST | 163 |
Proteomic databases
MaxQBi | Q9BUY7. |
PaxDbi | Q9BUY7. |
PeptideAtlasi | Q9BUY7. |
PRIDEi | Q9BUY7. |
PTM databases
iPTMneti | Q9BUY7. |
PhosphoSitePlusi | Q9BUY7. |
Expressioni
Gene expression databases
Bgeei | ENSG00000140025. |
CleanExi | HS_C14orf143. |
ExpressionAtlasi | Q9BUY7. baseline and differential. |
Genevisiblei | Q9BUY7. HS. |
Organism-specific databases
HPAi | HPA051209. |
Interactioni
Protein-protein interaction databases
BioGridi | 124670. 10 interactors. |
STRINGi | 9606.ENSP00000326267. |
Structurei
3D structure databases
ProteinModelPortali | Q9BUY7. |
SMRi | Q9BUY7. |
ModBasei | Search... |
MobiDBi | Search... |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 18 – 53 | EF-hand 1PROSITE-ProRule annotationAdd BLAST | 36 | |
Domaini | 91 – 126 | EF-hand 2PROSITE-ProRule annotationAdd BLAST | 36 | |
Domaini | 127 – 162 | EF-hand 3PROSITE-ProRule annotationAdd BLAST | 36 |
Keywords - Domaini
RepeatPhylogenomic databases
eggNOGi | KOG0027. Eukaryota. COG5126. LUCA. |
GeneTreei | ENSGT00390000004917. |
HOGENOMi | HOG000007716. |
HOVERGENi | HBG106107. |
InParanoidi | Q9BUY7. |
OMAi | FKQVAPK. |
OrthoDBi | EOG091G0S7R. |
PhylomeDBi | Q9BUY7. |
TreeFami | TF329255. |
Family and domain databases
CDDi | cd00051. EFh. 1 hit. |
InterProi | View protein in InterPro IPR011992. EF-hand-dom_pair. IPR018247. EF_Hand_1_Ca_BS. IPR002048. EF_hand_dom. |
Pfami | View protein in Pfam PF13499. EF-hand_7. 1 hit. PF13833. EF-hand_8. 1 hit. |
SMARTi | View protein in SMART SM00054. EFh. 3 hits. |
SUPFAMi | SSF47473. SSF47473. 1 hit. |
PROSITEi | View protein in PROSITE PS00018. EF_HAND_1. 1 hit. PS50222. EF_HAND_2. 3 hits. |
s (6)i Sequence
Sequence statusi: Complete.
This entry describes 6 produced by isoformsialternative splicing. AlignAdd to basket
Isoform 1 (identifier: Q9BUY7-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
10 20 30 40 50
MFFSEARARS RTWEASPSEH RKWVEVFKAC DEDHKGYLSR EDFKTAVVML
60 70 80 90 100
FGYKPSKIEV DSVMSSINPN TSGILLEGFL NIVRKKKEAQ RYRNEVRHIF
110 120 130 140 150
TAFDTYYRGF LTLEDFKKAF RQVAPKLPER TVLEVFREVD RDSDGHVSFR
160
DFEYALNYGQ KEA
Isoform 4 (identifier: Q9BUY7-4) [UniParc]FASTAAdd to basket
The sequence of this isoform differs from the canonical sequence as follows:
58-61: IEVD → KWIL
62-163: Missing.
Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. No experimental confirmation available.
Show »Sequence cautioni
The sequence CAD62325 differs from that shown. Reason: Erroneous translation. Wrong choice of CDS.Curated
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_032129 | 15 | A → V. Corresponds to variant dbSNP:rs35435801Ensembl. | 1 | |
Natural variantiVAR_032130 | 31 | D → G. Corresponds to variant dbSNP:rs34486581Ensembl. | 1 | |
Natural variantiVAR_032131 | 45 | T → A. Corresponds to variant dbSNP:rs34911716Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_055729 | 1 – 48 | Missing in isoform 6. CuratedAdd BLAST | 48 | |
Alternative sequenceiVSP_025100 | 1 – 25 | MFFSE…RKWVE → M in isoform 2 and isoform 3. 2 PublicationsAdd BLAST | 25 | |
Alternative sequenceiVSP_041089 | 58 – 61 | IEVD → KWIL in isoform 4. 1 Publication | 4 | |
Alternative sequenceiVSP_041090 | 62 – 163 | Missing in isoform 4. 1 PublicationAdd BLAST | 102 | |
Alternative sequenceiVSP_025101 | 138 – 163 | EVDRD…GQKEA → GIFSA in isoform 3. 1 PublicationAdd BLAST | 26 | |
Alternative sequenceiVSP_054591 | 138 – 162 | EVDRD…YGQKE → GIFS in isoform 5. 1 PublicationAdd BLAST | 25 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BX161414 mRNA. Translation: CAD61889.1. BX247991 mRNA. Translation: CAD62325.1. Sequence problems. AK094740 mRNA. Translation: BAG52922.1. AK298930 mRNA. Translation: BAH12905.1. AL832321 mRNA. Translation: CAD38616.1. AL137128 Genomic DNA. No translation available. AL137230 Genomic DNA. No translation available. AL163011 Genomic DNA. No translation available. CH471061 Genomic DNA. Translation: EAW81411.1. BC001787 mRNA. Translation: AAH01787.1. |
CCDSi | CCDS61522.1. [Q9BUY7-6] CCDS61523.1. [Q9BUY7-2] CCDS61524.1. [Q9BUY7-3] CCDS61525.1. [Q9BUY7-5] CCDS9887.1. [Q9BUY7-1] |
RefSeqi | NP_001271195.1. NM_001284266.1. [Q9BUY7-5] NP_001271196.1. NM_001284267.1. [Q9BUY7-6] NP_001271197.1. NM_001284268.1. [Q9BUY7-3] NP_001271198.1. NM_001284269.1. [Q9BUY7-2] NP_660274.1. NM_145231.3. [Q9BUY7-1] |
UniGenei | Hs.123232. |
Genome annotation databases
Keywords - Coding sequence diversityi
Alternative splicing, PolymorphismSimilar proteinsi
Entry informationi
Entry namei | EFC11_HUMAN | |
Accessioni | Q9BUY7Primary (citable) accession number: Q9BUY7 Secondary accession number(s): B3KT10 Q8NDQ1 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | May 15, 2007 |
Last sequence update: | June 1, 2001 | |
Last modified: | January 31, 2018 | |
This is version 128 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |