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Protein

Zinc finger protein 426

Gene

ZNF426

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri146 – 17429C2H2-type 1; atypicalPROSITE-ProRule annotationAdd
BLAST
Zinc fingeri224 – 24623C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri280 – 30223C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri308 – 33023C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri336 – 35823C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri364 – 38623C2H2-type 6PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri392 – 41423C2H2-type 7PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri420 – 44223C2H2-type 8PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri448 – 47023C2H2-type 9PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri476 – 49823C2H2-type 10PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri504 – 52623C2H2-type 11PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri532 – 55423C2H2-type 12PROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Enzyme and pathway databases

ReactomeiREACT_12627. Generic Transcription Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 426
Gene namesi
Name:ZNF426
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 19

Organism-specific databases

HGNCiHGNC:20725. ZNF426.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134991761.

Polymorphism and mutation databases

BioMutaiZNF426.
DMDMi34925651.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 554554Zinc finger protein 426PRO_0000047576Add
BLAST

Proteomic databases

MaxQBiQ9BUY5.
PaxDbiQ9BUY5.
PRIDEiQ9BUY5.

PTM databases

PhosphoSiteiQ9BUY5.

Expressioni

Gene expression databases

BgeeiQ9BUY5.
CleanExiHS_ZNF426.
ExpressionAtlasiQ9BUY5. baseline and differential.
GenevisibleiQ9BUY5. HS.

Organism-specific databases

HPAiHPA029342.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
CIB3Q96Q773EBI-743265,EBI-10292696
GLRX3O760033EBI-743265,EBI-374781
LZTS2Q9BRK43EBI-743265,EBI-741037
MPPE1Q53F393EBI-743265,EBI-10242229
MTUS2Q5JR593EBI-743265,EBI-742948
TSGA10Q9BZW73EBI-743265,EBI-744794
USP25Q9UHP33EBI-743265,EBI-2513462

Protein-protein interaction databases

BioGridi122536. 18 interactions.
IntActiQ9BUY5. 16 interactions.
MINTiMINT-1459571.
STRINGi9606.ENSP00000253115.

Structurei

3D structure databases

ProteinModelPortaliQ9BUY5.
SMRiQ9BUY5. Positions 42-82, 148-554.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini42 – 11271KRABPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 12 C2H2-type zinc fingers.PROSITE-ProRule annotation
Contains 1 KRAB domain.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri146 – 17429C2H2-type 1; atypicalPROSITE-ProRule annotationAdd
BLAST
Zinc fingeri224 – 24623C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri280 – 30223C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri308 – 33023C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri336 – 35823C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri364 – 38623C2H2-type 6PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri392 – 41423C2H2-type 7PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri420 – 44223C2H2-type 8PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri448 – 47023C2H2-type 9PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri476 – 49823C2H2-type 10PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri504 – 52623C2H2-type 11PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri532 – 55423C2H2-type 12PROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiCOG5048.
GeneTreeiENSGT00530000063830.
HOGENOMiHOG000234617.
HOVERGENiHBG018163.
InParanoidiQ9BUY5.
KOiK09228.
OMAiAFNYSTH.
OrthoDBiEOG7KSX7Q.
PhylomeDBiQ9BUY5.
TreeFamiTF342172.

Family and domain databases

Gene3Di3.30.160.60. 11 hits.
InterProiIPR001909. Krueppel-associated_box.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF01352. KRAB. 1 hit.
PF00096. zf-C2H2. 1 hit.
[Graphical view]
SMARTiSM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 12 hits.
[Graphical view]
SUPFAMiSSF109640. SSF109640. 1 hit.
PROSITEiPS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 11 hits.
PS50157. ZINC_FINGER_C2H2_2. 12 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9BUY5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAADLSHGH YLSGDPVCLH EEKTPAGRIV ADCLTDCYQD SVTFDDVAVD
60 70 80 90 100
FTQEEWTLLD STQRSLYSDV MLENYKNLAT VGGQIIKPSL ISWLEQEESR
110 120 130 140 150
TVQGGVLQGW EMRLETQWSI LQQDFLRGQT SIGIQLEGKH NGRELCDCEQ
160 170 180 190 200
CGEVFSEHSC LKTHVRTQST GNTHDCNQYG KDFLTLCEKT STGEKLSEFN
210 220 230 240 250
QSEKIFSLTP NIVYQRTSTQ EKSFECSHCG KSFINESYLQ AHMRTHNGEK
260 270 280 290 300
LYEWRNYGPG FIDSTSLSVL IETLNAKKPY KCKECGKGYR YPAYLSIHMR
310 320 330 340 350
THTGEKPYEC KECGKAFNYS NSFQIHGRTH TGEKPYVCKE CGKAFTQYSG
360 370 380 390 400
LSMHVRSHSG DKPYECKECG KSFLTSSRLI QHIRTHTGEK PFVCVECGKA
410 420 430 440 450
FAVSSNLSGH LRTHTEEKAC ECKICGKVFG YPSCLNNHMR THSAQKPYTC
460 470 480 490 500
KECGKAFNYS THLKIHMRIH TGEKPYECKQ CGKAFSHSSS FQIHERTHTG
510 520 530 540 550
EKPYECKECG KAFTCSSSFR IHEKTHTEEK PYKCQQCGKA YSHPRSLRRH

EQIH
Length:554
Mass (Da):63,106
Last modified:June 1, 2001 - v1
Checksum:i8490888CC9537F9C
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti4 – 41A → V.
Corresponds to variant rs2042200 [ dbSNP | Ensembl ].
VAR_024214
Natural varianti219 – 2191T → A.
Corresponds to variant rs10420644 [ dbSNP | Ensembl ].
VAR_052824

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK095759 mRNA. Translation: BAG53124.1.
CH471106 Genomic DNA. Translation: EAW84039.1.
BC001791 mRNA. Translation: AAH01791.1.
CCDSiCCDS12215.1.
RefSeqiNP_001287812.1. NM_001300883.1.
NP_077011.1. NM_024106.1.
UniGeneiHs.594011.

Genome annotation databases

EnsembliENST00000253115; ENSP00000253115; ENSG00000130818.
ENST00000535489; ENSP00000439017; ENSG00000130818.
GeneIDi79088.
KEGGihsa:79088.
UCSCiuc002mlq.3. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK095759 mRNA. Translation: BAG53124.1.
CH471106 Genomic DNA. Translation: EAW84039.1.
BC001791 mRNA. Translation: AAH01791.1.
CCDSiCCDS12215.1.
RefSeqiNP_001287812.1. NM_001300883.1.
NP_077011.1. NM_024106.1.
UniGeneiHs.594011.

3D structure databases

ProteinModelPortaliQ9BUY5.
SMRiQ9BUY5. Positions 42-82, 148-554.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi122536. 18 interactions.
IntActiQ9BUY5. 16 interactions.
MINTiMINT-1459571.
STRINGi9606.ENSP00000253115.

PTM databases

PhosphoSiteiQ9BUY5.

Polymorphism and mutation databases

BioMutaiZNF426.
DMDMi34925651.

Proteomic databases

MaxQBiQ9BUY5.
PaxDbiQ9BUY5.
PRIDEiQ9BUY5.

Protocols and materials databases

DNASUi79088.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000253115; ENSP00000253115; ENSG00000130818.
ENST00000535489; ENSP00000439017; ENSG00000130818.
GeneIDi79088.
KEGGihsa:79088.
UCSCiuc002mlq.3. human.

Organism-specific databases

CTDi79088.
GeneCardsiGC19M009638.
HGNCiHGNC:20725. ZNF426.
HPAiHPA029342.
neXtProtiNX_Q9BUY5.
PharmGKBiPA134991761.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiCOG5048.
GeneTreeiENSGT00530000063830.
HOGENOMiHOG000234617.
HOVERGENiHBG018163.
InParanoidiQ9BUY5.
KOiK09228.
OMAiAFNYSTH.
OrthoDBiEOG7KSX7Q.
PhylomeDBiQ9BUY5.
TreeFamiTF342172.

Enzyme and pathway databases

ReactomeiREACT_12627. Generic Transcription Pathway.

Miscellaneous databases

GenomeRNAii79088.
NextBioi67913.
PROiQ9BUY5.

Gene expression databases

BgeeiQ9BUY5.
CleanExiHS_ZNF426.
ExpressionAtlasiQ9BUY5. baseline and differential.
GenevisibleiQ9BUY5. HS.

Family and domain databases

Gene3Di3.30.160.60. 11 hits.
InterProiIPR001909. Krueppel-associated_box.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF01352. KRAB. 1 hit.
PF00096. zf-C2H2. 1 hit.
[Graphical view]
SMARTiSM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 12 hits.
[Graphical view]
SUPFAMiSSF109640. SSF109640. 1 hit.
PROSITEiPS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 11 hits.
PS50157. ZINC_FINGER_C2H2_2. 12 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Skin.

Entry informationi

Entry nameiZN426_HUMAN
AccessioniPrimary (citable) accession number: Q9BUY5
Secondary accession number(s): B3KTL2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 19, 2003
Last sequence update: June 1, 2001
Last modified: June 24, 2015
This is version 120 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.