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Q9BUY5

- ZN426_HUMAN

UniProt

Q9BUY5 - ZN426_HUMAN

Protein

Zinc finger protein 426

Gene

ZNF426

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 114 (01 Oct 2014)
      Sequence version 1 (01 Jun 2001)
      Previous versions | rss
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    Functioni

    May be involved in transcriptional regulation.

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri146 – 17429C2H2-type 1; atypicalPROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri224 – 24623C2H2-type 2PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri280 – 30223C2H2-type 3PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri308 – 33023C2H2-type 4PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri336 – 35823C2H2-type 5PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri364 – 38623C2H2-type 6PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri392 – 41423C2H2-type 7PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri420 – 44223C2H2-type 8PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri448 – 47023C2H2-type 9PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri476 – 49823C2H2-type 10PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri504 – 52623C2H2-type 11PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri532 – 55423C2H2-type 12PROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. DNA binding Source: UniProtKB-KW
    2. metal ion binding Source: UniProtKB-KW

    GO - Biological processi

    1. regulation of transcription, DNA-templated Source: UniProtKB-KW
    2. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Biological processi

    Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding, Metal-binding, Zinc

    Enzyme and pathway databases

    ReactomeiREACT_12627. Generic Transcription Pathway.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Zinc finger protein 426
    Gene namesi
    Name:ZNF426
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 19

    Organism-specific databases

    HGNCiHGNC:20725. ZNF426.

    Subcellular locationi

    Nucleus Curated

    GO - Cellular componenti

    1. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Nucleus

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA134991761.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 554554Zinc finger protein 426PRO_0000047576Add
    BLAST

    Proteomic databases

    PaxDbiQ9BUY5.
    PRIDEiQ9BUY5.

    PTM databases

    PhosphoSiteiQ9BUY5.

    Expressioni

    Gene expression databases

    ArrayExpressiQ9BUY5.
    BgeeiQ9BUY5.
    CleanExiHS_ZNF426.
    GenevestigatoriQ9BUY5.

    Organism-specific databases

    HPAiHPA029342.

    Interactioni

    Protein-protein interaction databases

    BioGridi122536. 11 interactions.
    IntActiQ9BUY5. 9 interactions.
    MINTiMINT-1459571.
    STRINGi9606.ENSP00000253115.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9BUY5.
    SMRiQ9BUY5. Positions 42-82, 148-554.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini42 – 11271KRABPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 12 C2H2-type zinc fingers.PROSITE-ProRule annotation
    Contains 1 KRAB domain.PROSITE-ProRule annotation

    Zinc finger

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri146 – 17429C2H2-type 1; atypicalPROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri224 – 24623C2H2-type 2PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri280 – 30223C2H2-type 3PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri308 – 33023C2H2-type 4PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri336 – 35823C2H2-type 5PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri364 – 38623C2H2-type 6PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri392 – 41423C2H2-type 7PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri420 – 44223C2H2-type 8PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri448 – 47023C2H2-type 9PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri476 – 49823C2H2-type 10PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri504 – 52623C2H2-type 11PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri532 – 55423C2H2-type 12PROSITE-ProRule annotationAdd
    BLAST

    Keywords - Domaini

    Repeat, Zinc-finger

    Phylogenomic databases

    eggNOGiCOG5048.
    HOGENOMiHOG000234617.
    HOVERGENiHBG018163.
    InParanoidiQ9BUY5.
    KOiK09228.
    OMAiAFNYSTH.
    OrthoDBiEOG7KSX7Q.
    PhylomeDBiQ9BUY5.
    TreeFamiTF342172.

    Family and domain databases

    Gene3Di3.30.160.60. 11 hits.
    InterProiIPR001909. Krueppel-associated_box.
    IPR007087. Znf_C2H2.
    IPR015880. Znf_C2H2-like.
    IPR013087. Znf_C2H2/integrase_DNA-bd.
    [Graphical view]
    PfamiPF01352. KRAB. 1 hit.
    PF00096. zf-C2H2. 1 hit.
    [Graphical view]
    SMARTiSM00349. KRAB. 1 hit.
    SM00355. ZnF_C2H2. 12 hits.
    [Graphical view]
    SUPFAMiSSF109640. SSF109640. 1 hit.
    PROSITEiPS50805. KRAB. 1 hit.
    PS00028. ZINC_FINGER_C2H2_1. 11 hits.
    PS50157. ZINC_FINGER_C2H2_2. 12 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9BUY5-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAAADLSHGH YLSGDPVCLH EEKTPAGRIV ADCLTDCYQD SVTFDDVAVD    50
    FTQEEWTLLD STQRSLYSDV MLENYKNLAT VGGQIIKPSL ISWLEQEESR 100
    TVQGGVLQGW EMRLETQWSI LQQDFLRGQT SIGIQLEGKH NGRELCDCEQ 150
    CGEVFSEHSC LKTHVRTQST GNTHDCNQYG KDFLTLCEKT STGEKLSEFN 200
    QSEKIFSLTP NIVYQRTSTQ EKSFECSHCG KSFINESYLQ AHMRTHNGEK 250
    LYEWRNYGPG FIDSTSLSVL IETLNAKKPY KCKECGKGYR YPAYLSIHMR 300
    THTGEKPYEC KECGKAFNYS NSFQIHGRTH TGEKPYVCKE CGKAFTQYSG 350
    LSMHVRSHSG DKPYECKECG KSFLTSSRLI QHIRTHTGEK PFVCVECGKA 400
    FAVSSNLSGH LRTHTEEKAC ECKICGKVFG YPSCLNNHMR THSAQKPYTC 450
    KECGKAFNYS THLKIHMRIH TGEKPYECKQ CGKAFSHSSS FQIHERTHTG 500
    EKPYECKECG KAFTCSSSFR IHEKTHTEEK PYKCQQCGKA YSHPRSLRRH 550
    EQIH 554
    Length:554
    Mass (Da):63,106
    Last modified:June 1, 2001 - v1
    Checksum:i8490888CC9537F9C
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti4 – 41A → V.
    Corresponds to variant rs2042200 [ dbSNP | Ensembl ].
    VAR_024214
    Natural varianti219 – 2191T → A.
    Corresponds to variant rs10420644 [ dbSNP | Ensembl ].
    VAR_052824

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK095759 mRNA. Translation: BAG53124.1.
    CH471106 Genomic DNA. Translation: EAW84039.1.
    BC001791 mRNA. Translation: AAH01791.1.
    CCDSiCCDS12215.1.
    RefSeqiNP_077011.1. NM_024106.1.
    UniGeneiHs.594011.

    Genome annotation databases

    EnsembliENST00000253115; ENSP00000253115; ENSG00000130818.
    ENST00000535489; ENSP00000439017; ENSG00000130818.
    GeneIDi79088.
    KEGGihsa:79088.
    UCSCiuc002mlq.3. human.

    Polymorphism databases

    DMDMi34925651.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK095759 mRNA. Translation: BAG53124.1 .
    CH471106 Genomic DNA. Translation: EAW84039.1 .
    BC001791 mRNA. Translation: AAH01791.1 .
    CCDSi CCDS12215.1.
    RefSeqi NP_077011.1. NM_024106.1.
    UniGenei Hs.594011.

    3D structure databases

    ProteinModelPortali Q9BUY5.
    SMRi Q9BUY5. Positions 42-82, 148-554.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 122536. 11 interactions.
    IntActi Q9BUY5. 9 interactions.
    MINTi MINT-1459571.
    STRINGi 9606.ENSP00000253115.

    PTM databases

    PhosphoSitei Q9BUY5.

    Polymorphism databases

    DMDMi 34925651.

    Proteomic databases

    PaxDbi Q9BUY5.
    PRIDEi Q9BUY5.

    Protocols and materials databases

    DNASUi 79088.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000253115 ; ENSP00000253115 ; ENSG00000130818 .
    ENST00000535489 ; ENSP00000439017 ; ENSG00000130818 .
    GeneIDi 79088.
    KEGGi hsa:79088.
    UCSCi uc002mlq.3. human.

    Organism-specific databases

    CTDi 79088.
    GeneCardsi GC19M009638.
    HGNCi HGNC:20725. ZNF426.
    HPAi HPA029342.
    neXtProti NX_Q9BUY5.
    PharmGKBi PA134991761.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG5048.
    HOGENOMi HOG000234617.
    HOVERGENi HBG018163.
    InParanoidi Q9BUY5.
    KOi K09228.
    OMAi AFNYSTH.
    OrthoDBi EOG7KSX7Q.
    PhylomeDBi Q9BUY5.
    TreeFami TF342172.

    Enzyme and pathway databases

    Reactomei REACT_12627. Generic Transcription Pathway.

    Miscellaneous databases

    GenomeRNAii 79088.
    NextBioi 67913.
    PROi Q9BUY5.

    Gene expression databases

    ArrayExpressi Q9BUY5.
    Bgeei Q9BUY5.
    CleanExi HS_ZNF426.
    Genevestigatori Q9BUY5.

    Family and domain databases

    Gene3Di 3.30.160.60. 11 hits.
    InterProi IPR001909. Krueppel-associated_box.
    IPR007087. Znf_C2H2.
    IPR015880. Znf_C2H2-like.
    IPR013087. Znf_C2H2/integrase_DNA-bd.
    [Graphical view ]
    Pfami PF01352. KRAB. 1 hit.
    PF00096. zf-C2H2. 1 hit.
    [Graphical view ]
    SMARTi SM00349. KRAB. 1 hit.
    SM00355. ZnF_C2H2. 12 hits.
    [Graphical view ]
    SUPFAMi SSF109640. SSF109640. 1 hit.
    PROSITEi PS50805. KRAB. 1 hit.
    PS00028. ZINC_FINGER_C2H2_1. 11 hits.
    PS50157. ZINC_FINGER_C2H2_2. 12 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Brain.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Skin.

    Entry informationi

    Entry nameiZN426_HUMAN
    AccessioniPrimary (citable) accession number: Q9BUY5
    Secondary accession number(s): B3KTL2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 19, 2003
    Last sequence update: June 1, 2001
    Last modified: October 1, 2014
    This is version 114 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 19
      Human chromosome 19: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3