Q9BUX1Q0VIA0CHAC1_HUMANGlutathione-specific gamma-glutamylcyclotransferase 1Gamma-GCG 14.3.2.7Blocks Notch proteinBotchCation transport regulator-like protein 1CHAC1BOTCHHomo sapiensHumanEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomoCloning and analyzing of a new chaC like cDNA from human kidney.NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2)Analysis of the DNA sequence and duplication history of human chromosome 15.NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)CHAC1/MGC4504 is a novel proapoptotic component of the unfolded protein response, downstream of the ATF4-ATF3-CHOP cascade.FUNCTIONINDUCTIONSUBCELLULAR LOCATIONBotch promotes neurogenesis by antagonizing Notch.FUNCTIONChaC2, an enzyme for slow turnover of cytosolic glutathione.FUNCTIONCATALYTIC ACTIVITYBIOPHYSICOCHEMICAL PROPERTIESCatalyzes the cleavage of glutathione into 5-oxo-L-proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides (PubMed:27913623). Glutathione depletion is an important factor for apoptosis initiation and execution. Acts as a pro-apoptotic component of the unfolded protein response pathway by mediating the pro-apoptotic effects of the ATF4-ATF3-DDIT3/CHOP cascade (PubMed:19109178). Negative regulator of Notch signaling pathway involved in embryonic neurogenesis: acts by inhibiting Notch cleavage by furin, maintaining Notch in an immature inactive form, thereby promoting neurogenesis in embryos (PubMed:22445366).glutathione = 5-oxo-L-proline + L-cysteinylglycine2.2 mM for glutathionekcat is 225.2 min(-1) for glutathione.Interacts with NOTCH1 (via extracellular region).Q9BUX1Q9BQY4false2CytoplasmCytosolGolgi apparatusTrans-Golgi networkQ9BUX1-11Q9BUX1-22Induced by chemical activators of the unfolded protein response (UPR) such as tunicamycin, DTT and thapsigargin.Belongs to the gamma-glutamylcyclotransferase family. ChaC subfamily.Alternative splicingApoptosisCytoplasmGolgi apparatusLyaseNeurogenesisNotch signaling pathwayReference proteomeUnfolded protein responsesubstratePHMKQESAAPNTPPTSQSPTPSAQFPRNDGDPQALWIFGYGSLVWRPDFAYSDSRVGFVRGYSRRFWQGDTFHRGSDKMPGRVVTLLEDHEGCTWGVAYQVQGEQVSKALKYLNVREAVLGGYDTKEVTFYPQDAPDQPLKALAYVATPQNPGYLGPAPEEAIATQILACRGFSGHNLEYLLRLADFMQLCGPQAQDEHLAAIVDAVGTMLPCFCPTEQALALV
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