Q9BUX1 (CHAC1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Cation transport regulator-like protein 1

Gene names

Name:

CHAC1

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	264 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Pro-apoptotic component of the unfolded protein response pathway. May mediate the pro-apoptotic effects of the ATF4-ATF3-DDIT3/CHOP cascade. Ref.4
Subcellular location	Cytoplasm › cytosol Ref.4.
Induction	Induced by chemical activators of the unfolded protein response (UPR) such as tunicamycin, DTT and thapsigargin. Ref.4
Sequence similarities	Belongs to the chaC family.
Caution	It is uncertain whether Met-1 or Met-43 is the initiator. Met-1 is not conserved in orthologs.
Sequence caution	The sequence AAH01683.1 differs from that shown. Reason: Erroneous initiation. The sequence AAH01847.1 differs from that shown. Reason: Erroneous initiation. The sequence AAH19625.1 differs from that shown. Reason: Erroneous initiation. The sequence AAW23972.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
Biological process	Apoptosis Unfolded protein response
Cellular component	Cytoplasm
Coding sequence diversity	Alternative splicing
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	apoptosis in response to endoplasmic reticulum stress Inferred from mutant phenotype Ref.4. Source: UniProtKB response to unfolded protein Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytosol Inferred from direct assay Ref.4. Source: UniProtKB
Molecular function	protein binding Inferred from physical interaction. Source: IntAct
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
RHOXF2	Q9BQY4	2	EBI-751127,EBI-372094

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q9BUX1-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q9BUX1-2)

The sequence of this isoform differs from the canonical sequence as follows:
     146-190: Missing.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 264	264	Cation transport regulator-like protein 1		PRO_0000239010
Natural variations
	Alternative sequence	146 – 190	45	Missing in isoform 2.		VSP_038960
Experimental info
	Sequence conflict	10 – 12	3	SGA → ARG in AAH01683. Ref.2
	Sequence conflict	59	1	P → H in AAW23972. Ref.3

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified April 20, 2010. Version 2. Checksum: 746047C1AD03D375	FASTA	264	28,747
	10 20 30 40 50 60 MGGAQLELPS GARPGVCVRR SFRAHAGDQP RRPPGPIPVP GTMKQESAAP NTPPTSQSPT 70 80 90 100 110 120 PSAQFPRNDG DPQALWIFGY GSLVWRPDFA YSDSRVGFVR GYSRRFWQGD TFHRGSDKMP 130 140 150 160 170 180 GRVVTLLEDH EGCTWGVAYQ VQGEQVSKAL KYLNVREAVL GGYDTKEVTF YPQDAPDQPL 190 200 210 220 230 240 KALAYVATPQ NPGYLGPAPE EAIATQILAC RGFSGHNLEY LLRLADFMQL CGPQAQDEHL 250 260 AAIVDAVGTM LPCFCPTEQA LALV
	Isoform 2 [UniParc]. Checksum: A7EC06A98FB979EA	FASTA	219	23,795
	10 20 30 40 50 60 MGGAQLELPS GARPGVCVRR SFRAHAGDQP RRPPGPIPVP GTMKQESAAP NTPPTSQSPT 70 80 90 100 110 120 PSAQFPRNDG DPQALWIFGY GSLVWRPDFA YSDSRVGFVR GYSRRFWQGD TFHRGSDKMP 130 140 150 160 170 180 GRVVTLLEDH EGCTWGVAYQ VQGEQNPGYL GPAPEEAIAT QILACRGFSG HNLEYLLRLA 190 200 210 DFMQLCGPQA QDEHLAAIVD AVGTMLPCFC PTEQALALV

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Analysis of the DNA sequence and duplication history of human chromosome 15." Zody M.C., Garber M., Sharpe T., Young S.K., Rowen L., O'Neill K., Whittaker C.A., Kamal M., Chang J.L., Cuomo C.A., Dewar K., FitzGerald M.G., Kodira C.D., Madan A., Qin S., Yang X., Abbasi N., Abouelleil A. , Arachchi H.M., Baradarani L., Birditt B., Bloom S., Bloom T., Borowsky M.L., Burke J., Butler J., Cook A., DeArellano K., DeCaprio D., Dorris L. III, Dors M., Eichler E.E., Engels R., Fahey J., Fleetwood P., Friedman C., Gearin G., Hall J.L., Hensley G., Johnson E., Jones C., Kamat A., Kaur A., Locke D.P., Madan A., Munson G., Jaffe D.B., Lui A., Macdonald P., Mauceli E., Naylor J.W., Nesbitt R., Nicol R., O'Leary S.B., Ratcliffe A., Rounsley S., She X., Sneddon K.M.B., Stewart S., Sougnez C., Stone S.M., Topham K., Vincent D., Wang S., Zimmer A.R., Birren B.W., Hood L., Lander E.S., Nusbaum C. Nature 440:671-675(2006) [PubMed: 16572171] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[2]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 9-264 (ISOFORM 1). Tissue: Liver and Muscle.
[3]	"Cloning and analyzing of a new chaC like cDNA from human kidney." Zheng J.M., Liu Z.H., Li L.S. Submitted (JUL-2004) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 41-264 (ISOFORM 2).
[4]	"CHAC1/MGC4504 is a novel proapoptotic component of the unfolded protein response, downstream of the ATF4-ATF3-CHOP cascade." Mungrue I.N., Pagnon J., Kohannim O., Gargalovic P.S., Lusis A.J. J. Immunol. 182:466-476(2009) [PubMed: 19109178] [Abstract] Cited for: FUNCTION, INDUCTION, SUBCELLULAR LOCATION.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AC020661 Genomic DNA. No translation available. BC001683 mRNA. Translation: AAH01683.1. Different initiation. BC001847 mRNA. Translation: AAH01847.1. Different initiation. BC019625 mRNA. Translation: AAH19625.1. Different initiation. AY702027 mRNA. Translation: AAW23972.1. Different initiation.
IPI	IPI00012214. IPI00784879.
RefSeq	NP_001136248.1. NM_001142776.1. NP_077016.2. NM_024111.3.
UniGene	Hs.155569.
3D structure databases
ProteinModelPortal	Q9BUX1.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q9BUX1. 1 interaction.
MINT	MINT-1451921.
STRING	Q9BUX1.
Polymorphism databases
DMDM	294862423.
Proteomic databases
PRIDE	Q9BUX1.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000249798; ENSP00000249798; ENSG00000128965. ENST00000397434; ENSP00000380577; ENSG00000128965. ENST00000444189; ENSP00000395466; ENSG00000128965. ENST00000446533; ENSP00000398105; ENSG00000128965.
GeneID	79094.
KEGG	hsa:79094.
UCSC	uc001znh.1. human.
Organism-specific databases
CTD	79094.
GeneCards	GC15P041245.
HGNC	HGNC:28680. CHAC1.
neXtProt	NX_Q9BUX1.
PharmGKB	PA142672119.
GenAtlas	Search...
Phylogenomic databases
eggNOG	prNOG05966.
GeneTree	ENSGT00390000003855.
HOGENOM	HBG522249.
HOVERGEN	HBG056733.
InParanoid	Q9BUX1.
OMA	GDPQALW.
OrthoDB	EOG40CHJ2.
PhylomeDB	Q9BUX1.
Gene expression databases
ArrayExpress	Q9BUX1.
Bgee	Q9BUX1.
CleanEx	HS_CHAC1.
Genevestigator	Q9BUX1.
GermOnline	ENSG00000128965. Homo sapiens.
Family and domain databases
InterPro	IPR013024. Butirosin_synth_BtrG-like. IPR006840. ChaC. [Graphical view]
Gene3D	G3DSA:3.10.490.10. Butirosin_synth_BtrG-like. 1 hit.
KO	K07232.
PANTHER	PTHR12192. ChaC. 1 hit.
Pfam	PF04752. ChaC. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	67939.

Entry information

Entry name

CHAC1_HUMAN

Accession

Primary (citable) accession number: Q9BUX1
Secondary accession number(s): Q0VIA0

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 30, 2006
Last sequence update:	April 20, 2010
Last modified:	January 25, 2012
This is version 71 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.