Q9BUV8 (CT024_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Uncharacterized protein C20orf24

Alternative name(s):
Rab5-interacting protein
Short name=RIP5

Gene names

Name:	C20orf24
ORF Names:	PNAS-11

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	137 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

Ontologies

Keywords
Coding sequence diversity	Alternative splicing
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
None. [Check GOA]

Alternative products

This entry describes 4 isoforms produced by alternative splicing. [Align] [Select]

Note: Experimental confirmation may be lacking for some isoforms.

Isoform 1 (identifier: Q9BUV8-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q9BUV8-2)

The sequence of this isoform differs from the canonical sequence as follows:
     118-137: CVADSFTTGHLDHLLHCHPL → IWIIFYTAIHYD

Isoform 3 (identifier: Q9BUV8-3)

The sequence of this isoform differs from the canonical sequence as follows:
     118-127: CVADSFTTGH → I

Isoform 4 (identifier: Q9BUV8-4)

The sequence of this isoform differs from the canonical sequence as follows:
     74-137: FCLINAGVLY...LDHLLHCHPL → KGHCCSGAVCVCDD

Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 137	137	Uncharacterized protein C20orf24		PRO_0000079415
Natural variations
	Alternative sequence	74 – 137	64	FCLIN…HCHPL → KGHCCSGAVCVCDD in isoform 4.		VSP_003795
	Alternative sequence	118 – 137	20	CVADS…HCHPL → IWIIFYTAIHYD in isoform 2.		VSP_003796
	Alternative sequence	118 – 127	10	CVADSFTTGH → I in isoform 3.		VSP_003797
Experimental info
	Sequence conflict	15 – 33	19	LANGA…LRSDA → PWANGASKSPSGVRCCGRR in AAB50849. Ref.6
	Sequence conflict	95 – 100	6	EEYGGT → GRILVAR in AAK07515. Ref.2
	Sequence conflict	100	1	T → Q in AAB50849. Ref.6
	Sequence conflict	110	1	T → P in AAB50849. Ref.6
	Sequence conflict	114 – 137	24	LFMVC…HCHPL → IVHGHLLLLFTSHPYSMMVS DSK in AAB50849. Ref.6
	Sequence conflict	137	1	L → FIT in AAK07515. Ref.2

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified June 1, 2001. Version 1. Checksum: 4DC7A8E5D61B4C57	FASTA	137	15,487
	10 20 30 40 50 60 MSGGRRKEEP PQPQLANGAL KVSVWSKVLR SDAAWEDKDE FLDVIYWFRQ IIAVVLGVIW 70 80 90 100 110 120 GVLPLRGFLG IAGFCLINAG VLYLYFSNYL QIDEEEYGGT WELTKEGFMT SFALFMVCVA 130 DSFTTGHLDH LLHCHPL
	Isoform 2 [UniParc]. Checksum: DA8C4AC79B9AFD22	FASTA	129	14,825
	10 20 30 40 50 60 MSGGRRKEEP PQPQLANGAL KVSVWSKVLR SDAAWEDKDE FLDVIYWFRQ IIAVVLGVIW 70 80 90 100 110 120 GVLPLRGFLG IAGFCLINAG VLYLYFSNYL QIDEEEYGGT WELTKEGFMT SFALFMVIWI IFYTAIHYD
	Isoform 3 [UniParc]. Checksum: BB48F128EAA15C26	FASTA	128	14,581
	10 20 30 40 50 60 MSGGRRKEEP PQPQLANGAL KVSVWSKVLR SDAAWEDKDE FLDVIYWFRQ IIAVVLGVIW 70 80 90 100 110 120 GVLPLRGFLG IAGFCLINAG VLYLYFSNYL QIDEEEYGGT WELTKEGFMT SFALFMVILD HLLHCHPL
	Isoform 4 [UniParc]. Checksum: 77A8B6359FD3660A	FASTA	87	9,530
	10 20 30 40 50 60 MSGGRRKEEP PQPQLANGAL KVSVWSKVLR SDAAWEDKDE FLDVIYWFRQ IIAVVLGVIW 70 80 GVLPLRGFLG IAGKGHCCSG AVCVCDD

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"A novel gene expressed in human adrenal gland." Jiang C., Zhang C., Huang C., Peng Y., Gu Y., Zhang L., Wu T., Li Y., Han Z., Wang Y., Chen Z., Fu G. Submitted (DEC-1998) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2). Tissue: Adrenal gland.
[2]	"Human acute promyelocytic leukemia cell line NB4's apoptosis related genes." Yu W.-Q., Sun B.-Z., Chai Y.-B., Zhu F., Liu X.-S., Li Z., Lu F., Yan W., Yang H., Zhao Z.-L. Submitted (JUN-2000) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3). Tissue: Promyelocytic leukemia.
[3]	"The DNA sequence and comparative analysis of human chromosome 20." Deloukas P., Matthews L.H., Ashurst J.L., Burton J., Gilbert J.G.R., Jones M., Stavrides G., Almeida J.P., Babbage A.K., Bagguley C.L., Bailey J., Barlow K.F., Bates K.N., Beard L.M., Beare D.M., Beasley O.P., Bird C.P., Blakey S.E. , Bridgeman A.M., Brown A.J., Buck D., Burrill W.D., Butler A.P., Carder C., Carter N.P., Chapman J.C., Clamp M., Clark G., Clark L.N., Clark S.Y., Clee C.M., Clegg S., Cobley V.E., Collier R.E., Connor R.E., Corby N.R., Coulson A., Coville G.J., Deadman R., Dhami P.D., Dunn M., Ellington A.G., Frankland J.A., Fraser A., French L., Garner P., Grafham D.V., Griffiths C., Griffiths M.N.D., Gwilliam R., Hall R.E., Hammond S., Harley J.L., Heath P.D., Ho S., Holden J.L., Howden P.J., Huckle E., Hunt A.R., Hunt S.E., Jekosch K., Johnson C.M., Johnson D., Kay M.P., Kimberley A.M., King A., Knights A., Laird G.K., Lawlor S., Lehvaeslaiho M.H., Leversha M.A., Lloyd C., Lloyd D.M., Lovell J.D., Marsh V.L., Martin S.L., McConnachie L.J., McLay K., McMurray A.A., Milne S.A., Mistry D., Moore M.J.F., Mullikin J.C., Nickerson T., Oliver K., Parker A., Patel R., Pearce T.A.V., Peck A.I., Phillimore B.J.C.T., Prathalingam S.R., Plumb R.W., Ramsay H., Rice C.M., Ross M.T., Scott C.E., Sehra H.K., Shownkeen R., Sims S., Skuce C.D., Smith M.L., Soderlund C., Steward C.A., Sulston J.E., Swann R.M., Sycamore N., Taylor R., Tee L., Thomas D.W., Thorpe A., Tracey A., Tromans A.C., Vaudin M., Wall M., Wallis J.M., Whitehead S.L., Whittaker P., Willey D.L., Williams L., Williams S.A., Wilming L., Wray P.W., Hubbard T., Durbin R.M., Bentley D.R., Beck S., Rogers J. Nature 414:865-871(2001) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 4). Tissue: Lung and Skin.
[6]	"The GDP/GTP cycle of Rab5 in the regulation of endocytotic membrane traffic." Vitale G., Alexandrov K., Ullrich O., Horiuchi H., Giner A., Dobson C., Baykova O., Gournier H., Stenmark H., Zerial M. Cold Spring Harb. Symp. Quant. Biol. 60:211-220(1995) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 15-137 (ISOFORM 1).
[7]	"An unappreciated role for RNA surveillance." Hillman R.T., Green R.E., Brenner S.E. Genome Biol. 5:R8.1-R8.16(2004) [PubMed] [Europe PMC] [Abstract] Cited for: SPLICE ISOFORM(S) THAT ARE POTENTIAL NMD TARGET(S).
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF112213 mRNA. Translation: AAF17201.1. AF274936 mRNA. Translation: AAK07515.1. AL050318 Genomic DNA. Translation: CAB75367.1. AL050318 Genomic DNA. Translation: CAI23511.1. CH471077 Genomic DNA. Translation: EAW76122.1. CH471077 Genomic DNA. Translation: EAW76120.1. CH471077 Genomic DNA. Translation: EAW76124.1. BC001871 mRNA. Translation: AAH01871.1. BC004446 mRNA. Translation: AAH04446.1. S83364 mRNA. Translation: AAB50849.1.
IPI	IPI00030898. IPI00216578. IPI00216579. IPI00216581.
RefSeq	NP_001186463.1. NM_001199534.1. NP_061328.1. NM_018840.4. NP_955777.1. NM_199483.2.
UniGene	Hs.584985.
3D structure databases
ProteinModelPortal	Q9BUV8.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q9BUV8. 1 interaction.
STRING	9606.ENSP00000341213.
PTM databases
PhosphoSite	Q9BUV8.
Polymorphism databases
DMDM	24211596.
Proteomic databases
PaxDb	Q9BUV8.
PRIDE	Q9BUV8.
Protocols and materials databases
DNASU	55969.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000344795; ENSP00000340164; ENSG00000101084. ENST00000373852; ENSP00000362958; ENSG00000101084. ENST00000483815; ENSP00000432510; ENSG00000101084. ENST00000492721; ENSP00000435871; ENSG00000101084.
GeneID	55969.
KEGG	hsa:55969.
UCSC	uc002xfo.3. human. uc002xfs.3. human.
Organism-specific databases
CTD	55969.
GeneCards	GC20P035234.
HGNC	HGNC:15870. C20orf24.
neXtProt	NX_Q9BUV8.
PharmGKB	PA25740.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG311375.
HOVERGEN	HBG051153.
OMA	FDSEASW.
OrthoDB	EOG4QVCDC.
Gene expression databases
ArrayExpress	Q9BUV8.
Bgee	Q9BUV8.
CleanEx	HS_C20orf24.
Genevestigator	Q9BUV8.
GermOnline	ENSG00000101084. Homo sapiens.
Family and domain databases
InterPro	IPR010742. Rab5ip. [Graphical view]
PANTHER	PTHR12906. PTHR12906. 1 hit.
ProtoNet	Search...
Other
GenomeRNAi	55969.
NextBio	61397.

Entry information

Entry name

CT024_HUMAN

Accession

Primary (citable) accession number: Q9BUV8
Secondary accession number(s): E1P5U0 , O00605, Q5QPG7, Q9BT03, Q9BZU7, Q9UI05

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 19, 2002
Last sequence update:	June 1, 2001
Last modified:	April 3, 2013
This is version 88 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.