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Q9BUV8

- CT024_HUMAN

UniProt

Q9BUV8 - CT024_HUMAN

Protein

Uncharacterized protein C20orf24

Gene

C20orf24

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli
  1. Names & Taxonomyi

    Protein namesi
    Recommended name:
    Uncharacterized protein C20orf24
    Alternative name(s):
    Rab5-interacting protein
    Short name:
    RIP5
    Gene namesi
    ORF Names:PNAS-11
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 20

    Organism-specific databases

    HGNCiHGNC:15870. C20orf24.

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA25740.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 137137Uncharacterized protein C20orf24PRO_0000079415Add
    BLAST

    Proteomic databases

    MaxQBiQ9BUV8.
    PaxDbiQ9BUV8.
    PRIDEiQ9BUV8.

    PTM databases

    PhosphoSiteiQ9BUV8.

    Expressioni

    Gene expression databases

    BgeeiQ9BUV8.
    CleanExiHS_C20orf24.
    GenevestigatoriQ9BUV8.

    Organism-specific databases

    HPAiHPA057387.

    Interactioni

    Protein-protein interaction databases

    BioGridi121015. 24 interactions.
    IntActiQ9BUV8. 1 interaction.
    STRINGi9606.ENSP00000341213.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9BUV8.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Phylogenomic databases

    eggNOGiNOG311375.
    HOVERGENiHBG051153.
    OMAiDHLLHCH.
    OrthoDBiEOG7W6WNG.
    PhylomeDBiQ9BUV8.

    Family and domain databases

    InterProiIPR010742. Rab5ip.
    IPR029008. Rab5IP_fam.
    [Graphical view]
    PANTHERiPTHR12906. PTHR12906. 1 hit.
    PfamiPF07019. Rab5ip. 1 hit.
    [Graphical view]

    Sequences (5)i

    Sequence statusi: Complete.

    This entry describes 5 isoformsi produced by alternative splicing. Align

    Note: Experimental confirmation may be lacking for some isoforms.

    Isoform 1 (identifier: Q9BUV8-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MSGGRRKEEP PQPQLANGAL KVSVWSKVLR SDAAWEDKDE FLDVIYWFRQ    50
    IIAVVLGVIW GVLPLRGFLG IAGFCLINAG VLYLYFSNYL QIDEEEYGGT 100
    WELTKEGFMT SFALFMVCVA DSFTTGHLDH LLHCHPL 137
    Length:137
    Mass (Da):15,487
    Last modified:June 1, 2001 - v1
    Checksum:i4DC7A8E5D61B4C57
    GO
    Isoform 2 (identifier: Q9BUV8-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         118-137: CVADSFTTGHLDHLLHCHPL → IWIIFYTAIHYD

    Show »
    Length:129
    Mass (Da):14,825
    Checksum:iDA8C4AC79B9AFD22
    GO
    Isoform 3 (identifier: Q9BUV8-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         118-127: CVADSFTTGH → I

    Show »
    Length:128
    Mass (Da):14,581
    Checksum:iBB48F128EAA15C26
    GO
    Isoform 4 (identifier: Q9BUV8-4) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         74-137: FCLINAGVLY...LDHLLHCHPL → KGHCCSGAVCVCDD

    Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.

    Show »
    Length:87
    Mass (Da):9,530
    Checksum:i77A8B6359FD3660A
    GO
    Isoform 5 (identifier: Q9BUV8-5) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         74-137: FCLINAGVLY...LDHLLHCHPL → SFGSSFTLPS...ASVFSARVVT

    Note: Gene prediction based on EST data.

    Show »
    Length:143
    Mass (Da):15,893
    Checksum:i51AE78E40CF4F979
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti15 – 3319LANGA…LRSDA → PWANGASKSPSGVRCCGRR in AAB50849. (PubMed:8824393)CuratedAdd
    BLAST
    Sequence conflicti95 – 1006EEYGGT → GRILVAR in AAK07515. 1 PublicationCurated
    Sequence conflicti100 – 1001T → Q in AAB50849. (PubMed:8824393)Curated
    Sequence conflicti110 – 1101T → P in AAB50849. (PubMed:8824393)Curated
    Sequence conflicti114 – 13724LFMVC…HCHPL → IVHGHLLLLFTSHPYSMMVS DSK in AAB50849. (PubMed:8824393)CuratedAdd
    BLAST
    Sequence conflicti137 – 1371L → FIT in AAK07515. 1 PublicationCurated

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei74 – 13764FCLIN…HCHPL → KGHCCSGAVCVCDD in isoform 4. 1 PublicationVSP_003795Add
    BLAST
    Alternative sequencei74 – 13764FCLIN…HCHPL → SFGSSFTLPSIMTDGVQLPS APYPVQRTLLITAQELDRWG TPAPWNLEDPCFLDRESVCW ASVFSARVVT in isoform 5. CuratedVSP_047233Add
    BLAST
    Alternative sequencei118 – 13720CVADS…HCHPL → IWIIFYTAIHYD in isoform 2. 1 PublicationVSP_003796Add
    BLAST
    Alternative sequencei118 – 12710CVADSFTTGH → I in isoform 3. 1 PublicationVSP_003797

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF112213 mRNA. Translation: AAF17201.1.
    AF274936 mRNA. Translation: AAK07515.1.
    AL050318 Genomic DNA. Translation: CAB75367.1.
    AL050318 Genomic DNA. Translation: CAI23511.1.
    CH471077 Genomic DNA. Translation: EAW76122.1.
    CH471077 Genomic DNA. Translation: EAW76120.1.
    CH471077 Genomic DNA. Translation: EAW76123.1.
    CH471077 Genomic DNA. Translation: EAW76124.1.
    BC001871 mRNA. Translation: AAH01871.1.
    BC004446 mRNA. Translation: AAH04446.1.
    S83364 mRNA. Translation: AAB50849.1.
    CCDSiCCDS13279.1. [Q9BUV8-5]
    CCDS13280.1. [Q9BUV8-2]
    CCDS56190.1. [Q9BUV8-1]
    RefSeqiNP_001186463.1. NM_001199534.1. [Q9BUV8-1]
    NP_061328.1. NM_018840.4. [Q9BUV8-2]
    NP_955777.1. NM_199483.2. [Q9BUV8-5]
    UniGeneiHs.584985.

    Genome annotation databases

    EnsembliENST00000342422; ENSP00000341213; ENSG00000101084. [Q9BUV8-5]
    ENST00000344795; ENSP00000340164; ENSG00000101084. [Q9BUV8-2]
    ENST00000373852; ENSP00000362958; ENSG00000101084. [Q9BUV8-1]
    ENST00000483815; ENSP00000432510; ENSG00000101084. [Q9BUV8-4]
    ENST00000492721; ENSP00000435871; ENSG00000101084. [Q9BUV8-4]
    GeneIDi55969.
    KEGGihsa:55969.
    UCSCiuc002xfq.3. human. [Q9BUV8-2]
    uc002xfr.3. human.
    uc002xfs.3. human. [Q9BUV8-1]

    Polymorphism databases

    DMDMi24211596.

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF112213 mRNA. Translation: AAF17201.1 .
    AF274936 mRNA. Translation: AAK07515.1 .
    AL050318 Genomic DNA. Translation: CAB75367.1 .
    AL050318 Genomic DNA. Translation: CAI23511.1 .
    CH471077 Genomic DNA. Translation: EAW76122.1 .
    CH471077 Genomic DNA. Translation: EAW76120.1 .
    CH471077 Genomic DNA. Translation: EAW76123.1 .
    CH471077 Genomic DNA. Translation: EAW76124.1 .
    BC001871 mRNA. Translation: AAH01871.1 .
    BC004446 mRNA. Translation: AAH04446.1 .
    S83364 mRNA. Translation: AAB50849.1 .
    CCDSi CCDS13279.1. [Q9BUV8-5 ]
    CCDS13280.1. [Q9BUV8-2 ]
    CCDS56190.1. [Q9BUV8-1 ]
    RefSeqi NP_001186463.1. NM_001199534.1. [Q9BUV8-1 ]
    NP_061328.1. NM_018840.4. [Q9BUV8-2 ]
    NP_955777.1. NM_199483.2. [Q9BUV8-5 ]
    UniGenei Hs.584985.

    3D structure databases

    ProteinModelPortali Q9BUV8.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 121015. 24 interactions.
    IntActi Q9BUV8. 1 interaction.
    STRINGi 9606.ENSP00000341213.

    PTM databases

    PhosphoSitei Q9BUV8.

    Polymorphism databases

    DMDMi 24211596.

    Proteomic databases

    MaxQBi Q9BUV8.
    PaxDbi Q9BUV8.
    PRIDEi Q9BUV8.

    Protocols and materials databases

    DNASUi 55969.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000342422 ; ENSP00000341213 ; ENSG00000101084 . [Q9BUV8-5 ]
    ENST00000344795 ; ENSP00000340164 ; ENSG00000101084 . [Q9BUV8-2 ]
    ENST00000373852 ; ENSP00000362958 ; ENSG00000101084 . [Q9BUV8-1 ]
    ENST00000483815 ; ENSP00000432510 ; ENSG00000101084 . [Q9BUV8-4 ]
    ENST00000492721 ; ENSP00000435871 ; ENSG00000101084 . [Q9BUV8-4 ]
    GeneIDi 55969.
    KEGGi hsa:55969.
    UCSCi uc002xfq.3. human. [Q9BUV8-2 ]
    uc002xfr.3. human.
    uc002xfs.3. human. [Q9BUV8-1 ]

    Organism-specific databases

    CTDi 55969.
    GeneCardsi GC20P035234.
    HGNCi HGNC:15870. C20orf24.
    HPAi HPA057387.
    neXtProti NX_Q9BUV8.
    PharmGKBi PA25740.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG311375.
    HOVERGENi HBG051153.
    OMAi DHLLHCH.
    OrthoDBi EOG7W6WNG.
    PhylomeDBi Q9BUV8.

    Miscellaneous databases

    GenomeRNAii 55969.
    NextBioi 61397.

    Gene expression databases

    Bgeei Q9BUV8.
    CleanExi HS_C20orf24.
    Genevestigatori Q9BUV8.

    Family and domain databases

    InterProi IPR010742. Rab5ip.
    IPR029008. Rab5IP_fam.
    [Graphical view ]
    PANTHERi PTHR12906. PTHR12906. 1 hit.
    Pfami PF07019. Rab5ip. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "A novel gene expressed in human adrenal gland."
      Jiang C., Zhang C., Huang C., Peng Y., Gu Y., Zhang L., Wu T., Li Y., Han Z., Wang Y., Chen Z., Fu G.
      Submitted (DEC-1998) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
      Tissue: Adrenal gland.
    2. "Human acute promyelocytic leukemia cell line NB4's apoptosis related genes."
      Yu W.-Q., Sun B.-Z., Chai Y.-B., Zhu F., Liu X.-S., Li Z., Lu F., Yan W., Yang H., Zhao Z.-L.
      Submitted (JUN-2000) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
      Tissue: Promyelocytic leukemia.
    3. "The DNA sequence and comparative analysis of human chromosome 20."
      Deloukas P., Matthews L.H., Ashurst J.L., Burton J., Gilbert J.G.R., Jones M., Stavrides G., Almeida J.P., Babbage A.K., Bagguley C.L., Bailey J., Barlow K.F., Bates K.N., Beard L.M., Beare D.M., Beasley O.P., Bird C.P., Blakey S.E.
      , Bridgeman A.M., Brown A.J., Buck D., Burrill W.D., Butler A.P., Carder C., Carter N.P., Chapman J.C., Clamp M., Clark G., Clark L.N., Clark S.Y., Clee C.M., Clegg S., Cobley V.E., Collier R.E., Connor R.E., Corby N.R., Coulson A., Coville G.J., Deadman R., Dhami P.D., Dunn M., Ellington A.G., Frankland J.A., Fraser A., French L., Garner P., Grafham D.V., Griffiths C., Griffiths M.N.D., Gwilliam R., Hall R.E., Hammond S., Harley J.L., Heath P.D., Ho S., Holden J.L., Howden P.J., Huckle E., Hunt A.R., Hunt S.E., Jekosch K., Johnson C.M., Johnson D., Kay M.P., Kimberley A.M., King A., Knights A., Laird G.K., Lawlor S., Lehvaeslaiho M.H., Leversha M.A., Lloyd C., Lloyd D.M., Lovell J.D., Marsh V.L., Martin S.L., McConnachie L.J., McLay K., McMurray A.A., Milne S.A., Mistry D., Moore M.J.F., Mullikin J.C., Nickerson T., Oliver K., Parker A., Patel R., Pearce T.A.V., Peck A.I., Phillimore B.J.C.T., Prathalingam S.R., Plumb R.W., Ramsay H., Rice C.M., Ross M.T., Scott C.E., Sehra H.K., Shownkeen R., Sims S., Skuce C.D., Smith M.L., Soderlund C., Steward C.A., Sulston J.E., Swann R.M., Sycamore N., Taylor R., Tee L., Thomas D.W., Thorpe A., Tracey A., Tromans A.C., Vaudin M., Wall M., Wallis J.M., Whitehead S.L., Whittaker P., Willey D.L., Williams L., Williams S.A., Wilming L., Wray P.W., Hubbard T., Durbin R.M., Bentley D.R., Beck S., Rogers J.
      Nature 414:865-871(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 4).
      Tissue: Lung and Skin.
    6. "The GDP/GTP cycle of Rab5 in the regulation of endocytotic membrane traffic."
      Vitale G., Alexandrov K., Ullrich O., Horiuchi H., Giner A., Dobson C., Baykova O., Gournier H., Stenmark H., Zerial M.
      Cold Spring Harb. Symp. Quant. Biol. 60:211-220(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 15-137 (ISOFORM 1).
    7. Cited for: SPLICE ISOFORM(S) THAT ARE POTENTIAL NMD TARGET(S).

    Entry informationi

    Entry nameiCT024_HUMAN
    AccessioniPrimary (citable) accession number: Q9BUV8
    Secondary accession number(s): E1P5U0
    , O00605, Q5QPG6, Q5QPG7, Q9BT03, Q9BZU7, Q9UI05
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 19, 2002
    Last sequence update: June 1, 2001
    Last modified: October 1, 2014
    This is version 101 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 20
      Human chromosome 20: entries, gene names and cross-references to MIM

    External Data

    Dasty 3