Reviewed,
UniProtKB/Swiss-Prot Q9BUV8 (CT024_HUMAN)
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July 7, 2009.
Version 56.
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Names and origin · Protein attributes · Ontologies · Binary interactions · Alternative products · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents
Names and origin
| Protein names | Recommended name: Uncharacterized protein C20orf24 Alternative name(s): Rab5-interacting protein RIP5 | ||||
| Gene names |
| ||||
| Organism | Homo sapiens (Human) [Complete proteome] | ||||
| Taxonomic identifier | 9606 [NCBI] | ||||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Protein attributes
| Sequence length | 137 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is not processed. |
| Protein existence | Evidence at protein level. |
Ontologies
| Keywords | |
|---|---|
| Coding sequence diversity | Alternative splicing |
| Technical term | Complete proteome |
| Gene Ontology (GO) | |
| Molecular function | protein binding Inferred from physical interaction. Source: IntAct |
| Complete GO annotation... | |
Binary interactions
With | Entry | #Exp. | IntAct | Notes |
|---|---|---|---|---|
| ABCD3 | P28288 | 1 | EBI-1050079,EBI-80992 | |
| AIFM1 | O95831 | 1 | EBI-1050079,EBI-356440 | |
| ATAD3A | Q9NVI7 | 1 | EBI-1050079,EBI-352007 | |
| CLPX | O76031 | 1 | EBI-1050079,EBI-1052667 | |
| DYNC1H1 | Q14204 | 1 | EBI-1050079,EBI-356015 | |
| FANCI | Q9NVI1 | 1 | EBI-1050079,EBI-1013291 | |
| FAR1 | Q8WVX9 | 1 | EBI-1050079,EBI-1045879 | |
| GCN1L1 | Q92616 | 1 | EBI-1050079,EBI-356221 | |
| IPO11 | Q9UI26 | 1 | EBI-1050079,EBI-748752 | |
| PSMD3 | O43242 | 1 | EBI-1050079,EBI-357622 | |
| PTPLAD1 | Q9P035 | 1 | EBI-1050079,EBI-359013 | |
| RFXANK | O14593 | 1 | EBI-1050079,EBI-1057665 | |
| SLC25A12 | O75746 | 1 | EBI-1050079,EBI-1047585 | |
| SPTLC1 | O15269 | 1 | EBI-1050079,EBI-1044323 | |
| SSR3 | Q9UNL2 | 1 | EBI-1050079,EBI-1043938 | |
| SSR4 | P51571 | 1 | EBI-1050079,EBI-1054539 | |
| SURF4 | O15260 | 1 | EBI-1050079,EBI-1044848 | |
| TNPO3 | Q9Y5L0 | 1 | EBI-1050079,EBI-1042571 | |
| XPO7 | Q9UIA9 | 1 | EBI-1050079,EBI-286668 |
Alternative products
| This entry describes 4 isoforms produced by alternative splicing. [Align] [Select] Note: Experimental confirmation may be lacking for some isoforms. | ||||||
| Isoform 1 (identifier: Q9BUV8-1) This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. | ||||||
| Isoform 2 (identifier: Q9BUV8-2) The sequence of this isoform differs from the canonical sequence as follows: 118-137: CVADSFTTGHLDHLLHCHPL → IWIIFYTAIHYD | ||||||
| Isoform 3 (identifier: Q9BUV8-3) The sequence of this isoform differs from the canonical sequence as follows: 118-127: CVADSFTTGH → I | ||||||
| Isoform 4 (identifier: Q9BUV8-4) The sequence of this isoform differs from the canonical sequence as follows: 74-137: FCLINAGVLY...LDHLLHCHPL → KGHCCSGAVCVCDD | ||||||
| Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 137 | 137 | Uncharacterized protein C20orf24 | PRO_0000079415 | |||||
Natural variations | |||||||||
| Alternative sequence | 74 – 137 | 64 | FCLIN…HCHPL → KGHCCSGAVCVCDD in isoform 4. | VSP_003795 | |||||
| Alternative sequence | 118 – 137 | 20 | CVADS…HCHPL → IWIIFYTAIHYD in isoform 2. | VSP_003796 | |||||
| Alternative sequence | 118 – 127 | 10 | CVADSFTTGH → I in isoform 3. | VSP_003797 | |||||
Experimental info | |||||||||
| Sequence conflict | 15 – 33 | 19 | LANGA…LRSDA → PWANGASKSPSGVRCCGRR Ref.5 | ||||||
| Sequence conflict | 95 – 100 | 6 | EEYGGT → GRILVAR in AAK07515. Ref.2 | ||||||
| Sequence conflict | 100 | 1 | T → Q in AAB50849. Ref.5 | ||||||
| Sequence conflict | 110 | 1 | T → P in AAB50849. Ref.5 | ||||||
| Sequence conflict | 114 – 137 | 24 | LFMVC…HCHPL → IVHGHLLLFTSHPYSMMVSD SK Ref.5 | ||||||
| Sequence conflict | 137 | 1 | L → FIT in AAK07515. Ref.2 | ||||||
Sequences
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References
| « Hide 'large scale' references | |
| [1] | "A novel gene expressed in human adrenal gland." Jiang C., Zhang C., Huang C., Peng Y., Gu Y., Zhang L., Wu T., Li Y., Han Z., Wang Y., Chen Z., Fu G. Submitted (DEC-1998) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE (ISOFORM 2). Tissue: Adrenal gland. |
| [2] | "Human acute promyelocytic leukemia cell line NB4's apoptosis related genes." Yu W.-Q., Sun B.-Z., Chai Y.-B., Zhu F., Liu X.-S., Li Z., Lu F., Yan W., Yang H., Zhao Z.-L. Submitted (JUN-2000) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3). Tissue: Promyelocytic leukemia. |
| [3] | "The DNA sequence and comparative analysis of human chromosome 20." Deloukas P., Matthews L.H., Ashurst J.L., Burton J., Gilbert J.G.R., Jones M., Stavrides G., Almeida J.P., Babbage A.K., Bagguley C.L., Bailey J., Barlow K.F., Bates K.N., Beard L.M., Beare D.M., Beasley O.P., Bird C.P., Blakey S.E. Rogers J.Nature 414:865-871(2001) [PubMed: 11780052] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. |
| [4] | "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 4). Tissue: Lung and Skin. |
| [5] | "The GDP/GTP cycle of Rab5 in the regulation of endocytotic membrane traffic." Vitale G., Alexandrov K., Ullrich O., Horiuchi H., Giner A., Dobson C., Baykova O., Gournier H., Stenmark H., Zerial M. Cold Spring Harb. Symp. Quant. Biol. 60:211-220(1995) [PubMed: 8824393] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 15-137 (ISOFORM 1). |
| [6] | "An unappreciated role for RNA surveillance." Hillman R.T., Green R.E., Brenner S.E. Genome Biol. 5:RESEARCH008.1-RESEARCH008.16(2004) [PubMed: 14759258] [Abstract] Cited for: SPLICE ISOFORM(S) THAT ARE POTENTIAL NMD TARGET(S). |
Cross-references
Sequence databases | |
|---|---|
| AF112213 mRNA. Translation: AAF17201.1. AF274936 mRNA. Translation: AAK07515.1. AL050318 Genomic DNA. Translation: CAB75367.1. BC001871 mRNA. Translation: AAH01871.1. BC004446 mRNA. Translation: AAH04446.1. S83364 mRNA. Translation: AAB50849.1. | |
| IPI | IPI00030898. IPI00216578. IPI00216579. IPI00216581. |
| RefSeq | NP_061328.1. NP_955777.1. |
| UniGene | Hs.584985 |
3D structure databases | |
| ModBase | Search... |
Protein-protein interaction databases | |
| IntAct | Q9BUV8. 49 interactions. |
Genome annotation databases | |
| Ensembl | ENSG00000101084. Homo sapiens. [Contig view] |
| GeneID | 55969. |
| KEGG | hsa:55969. |
| UCSC | uc002xfp.1. human. uc002xfq.1. human. uc002xfs.1. human. |
Organism-specific databases | |
| GeneCards | GC20P034667. |
| HGNC | HGNC:15870. C20orf24. |
| PharmGKB | PA25740. |
| GenAtlas | Search... |
Phylogenomic databases | |
| HOVERGEN | Q9BUV8. |
Gene expression databases | |
| ArrayExpress | Q9BUV8. |
| Bgee | Q9BUV8. |
| CleanEx | HS_C20orf24. |
| GermOnline | ENSG00000101084. Homo sapiens. |
Family and domain databases | |
| InterPro | IPR010742. Rab5ip. [Graphical view] |
| PANTHER | PTHR12906. Rab5ip. 1 hit. |
| Pfam | PF07019. Rab5ip. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Other Resources | |
| NextBio | 61397. |
Entry information
| Entry name | CT024_HUMAN | ||||||||
| Accession | Primary (citable) accession number: Q9BUV8 Secondary accession number(s): O00605 Q9UI05 | ||||||||
| Entry history |
| ||||||||
| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HPI (Human Proteome Initiative) | ||||||||
Relevant documents
| Human chromosome 20 Human chromosome 20: entries, gene names and cross-references to MIM |

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