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Reviewed, UniProtKB/Swiss-Prot Q9BUV8 (CT024_HUMAN)

Last modified July 7, 2009. Version 56. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · Ontologies · Binary interactions · Alternative products · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein namesRecommended name:
    Uncharacterized protein C20orf24
Alternative name(s):
    Rab5-interacting protein
    RIP5
Gene names
Name: C20orf24
ORF Names: PNAS-11
OrganismHomo sapiens (Human) [Complete proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

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Protein attributes

Sequence length137 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceEvidence at protein level.

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Ontologies

Keywords
   Coding sequence diversityAlternative splicing
   Technical termComplete proteome
Gene Ontology (GO)
   Molecular functionprotein binding

Inferred from physical interaction. Source: IntAct

Complete GO annotation...

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Alternative products

This entry describes 4 isoforms produced by alternative splicing. [Align] [Select]

Note: Experimental confirmation may be lacking for some isoforms.
Isoform 1 (identifier: Q9BUV8-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q9BUV8-2)

The sequence of this isoform differs from the canonical sequence as follows:
     118-137: CVADSFTTGHLDHLLHCHPL → IWIIFYTAIHYD
Isoform 3 (identifier: Q9BUV8-3)

The sequence of this isoform differs from the canonical sequence as follows:
     118-127: CVADSFTTGH → I
Isoform 4 (identifier: Q9BUV8-4)

The sequence of this isoform differs from the canonical sequence as follows:
     74-137: FCLINAGVLY...LDHLLHCHPL → KGHCCSGAVCVCDD
Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.

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Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 137137Uncharacterized protein C20orf24
PRO_0000079415

Natural variations

Alternative sequence74 – 13764FCLIN…HCHPL → KGHCCSGAVCVCDD in isoform 4.
VSP_003795
Alternative sequence118 – 13720CVADS…HCHPL → IWIIFYTAIHYD in isoform 2.
VSP_003796
Alternative sequence118 – 12710CVADSFTTGH → I in isoform 3.
VSP_003797

Experimental info

Sequence conflict15 – 3319LANGA…LRSDA → PWANGASKSPSGVRCCGRR Ref.5
Sequence conflict95 – 1006EEYGGT → GRILVAR in AAK07515. Ref.2
Sequence conflict1001T → Q in AAB50849. Ref.5
Sequence conflict1101T → P in AAB50849. Ref.5
Sequence conflict114 – 13724LFMVC…HCHPL → IVHGHLLLFTSHPYSMMVSD SK Ref.5
Sequence conflict1371L → FIT in AAK07515. Ref.2

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Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified June 1, 2001. Version 1.
Checksum: 4DC7A8E5D61B4C57

FASTA13715,487
        10         20         30         40         50         60 
MSGGRRKEEP PQPQLANGAL KVSVWSKVLR SDAAWEDKDE FLDVIYWFRQ IIAVVLGVIW 

        70         80         90        100        110        120 
GVLPLRGFLG IAGFCLINAG VLYLYFSNYL QIDEEEYGGT WELTKEGFMT SFALFMVCVA 

       130 
DSFTTGHLDH LLHCHPL

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Isoform 2.

Checksum: DA8C4AC79B9AFD22
Show »

FASTA12914,825
Isoform 3.

Checksum: BB48F128EAA15C26
Show »

FASTA12814,581
Isoform 4.

Checksum: 77A8B6359FD3660A
Show »

FASTA879,530

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References

« Hide 'large scale' references
[1]"A novel gene expressed in human adrenal gland."
Jiang C., Zhang C., Huang C., Peng Y., Gu Y., Zhang L., Wu T., Li Y., Han Z., Wang Y., Chen Z., Fu G.
Submitted (DEC-1998) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE (ISOFORM 2).
Tissue: Adrenal gland.
[2]"Human acute promyelocytic leukemia cell line NB4's apoptosis related genes."
Yu W.-Q., Sun B.-Z., Chai Y.-B., Zhu F., Liu X.-S., Li Z., Lu F., Yan W., Yang H., Zhao Z.-L.
Submitted (JUN-2000) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
Tissue: Promyelocytic leukemia.
[3]"The DNA sequence and comparative analysis of human chromosome 20."
Deloukas P., Matthews L.H., Ashurst J.L., Burton J., Gilbert J.G.R., Jones M., Stavrides G., Almeida J.P., Babbage A.K., Bagguley C.L., Bailey J., Barlow K.F., Bates K.N., Beard L.M., Beare D.M., Beasley O.P., Bird C.P., Blakey S.E. expand/collapse author list , Bridgeman A.M., Brown A.J., Buck D., Burrill W.D., Butler A.P., Carder C., Carter N.P., Chapman J.C., Clamp M., Clark G., Clark L.N., Clark S.Y., Clee C.M., Clegg S., Cobley V.E., Collier R.E., Connor R.E., Corby N.R., Coulson A., Coville G.J., Deadman R., Dhami P.D., Dunn M., Ellington A.G., Frankland J.A., Fraser A., French L., Garner P., Grafham D.V., Griffiths C., Griffiths M.N.D., Gwilliam R., Hall R.E., Hammond S., Harley J.L., Heath P.D., Ho S., Holden J.L., Howden P.J., Huckle E., Hunt A.R., Hunt S.E., Jekosch K., Johnson C.M., Johnson D., Kay M.P., Kimberley A.M., King A., Knights A., Laird G.K., Lawlor S., Lehvaeslaiho M.H., Leversha M.A., Lloyd C., Lloyd D.M., Lovell J.D., Marsh V.L., Martin S.L., McConnachie L.J., McLay K., McMurray A.A., Milne S.A., Mistry D., Moore M.J.F., Mullikin J.C., Nickerson T., Oliver K., Parker A., Patel R., Pearce T.A.V., Peck A.I., Phillimore B.J.C.T., Prathalingam S.R., Plumb R.W., Ramsay H., Rice C.M., Ross M.T., Scott C.E., Sehra H.K., Shownkeen R., Sims S., Skuce C.D., Smith M.L., Soderlund C., Steward C.A., Sulston J.E., Swann R.M., Sycamore N., Taylor R., Tee L., Thomas D.W., Thorpe A., Tracey A., Tromans A.C., Vaudin M., Wall M., Wallis J.M., Whitehead S.L., Whittaker P., Willey D.L., Williams L., Williams S.A., Wilming L., Wray P.W., Hubbard T., Durbin R.M., Bentley D.R., Beck S., Rogers J.
Nature 414:865-871(2001) [PubMed: 11780052] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 4).
Tissue: Lung and Skin.
[5]"The GDP/GTP cycle of Rab5 in the regulation of endocytotic membrane traffic."
Vitale G., Alexandrov K., Ullrich O., Horiuchi H., Giner A., Dobson C., Baykova O., Gournier H., Stenmark H., Zerial M.
Cold Spring Harb. Symp. Quant. Biol. 60:211-220(1995) [PubMed: 8824393] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 15-137 (ISOFORM 1).
[6]"An unappreciated role for RNA surveillance."
Hillman R.T., Green R.E., Brenner S.E.
Genome Biol. 5:RESEARCH008.1-RESEARCH008.16(2004) [PubMed: 14759258] [Abstract]
Cited for: SPLICE ISOFORM(S) THAT ARE POTENTIAL NMD TARGET(S).

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Cross-references

Sequence databases

AF112213 mRNA. Translation: AAF17201.1.
AF274936 mRNA. Translation: AAK07515.1.
AL050318 Genomic DNA. Translation: CAB75367.1.
BC001871 mRNA. Translation: AAH01871.1.
BC004446 mRNA. Translation: AAH04446.1.
S83364 mRNA. Translation: AAB50849.1.
IPIIPI00030898.
IPI00216578.
IPI00216579.
IPI00216581.
RefSeqNP_061328.1.
NP_955777.1.
UniGeneHs.584985

3D structure databases

ModBaseSearch...

Protein-protein interaction databases

IntActQ9BUV8. 49 interactions.

Genome annotation databases

EnsemblENSG00000101084. Homo sapiens. [Contig view]
GeneID55969.
KEGGhsa:55969.
UCSCuc002xfp.1. human.
uc002xfq.1. human.
uc002xfs.1. human.

Organism-specific databases

GeneCardsGC20P034667.
HGNCHGNC:15870. C20orf24.
PharmGKBPA25740.
GenAtlasSearch...

Phylogenomic databases

HOVERGENQ9BUV8.

Gene expression databases

ArrayExpressQ9BUV8.
BgeeQ9BUV8.
CleanExHS_C20orf24.
GermOnlineENSG00000101084. Homo sapiens.

Family and domain databases

InterProIPR010742. Rab5ip.
[Graphical view]
PANTHERPTHR12906. Rab5ip. 1 hit.
PfamPF07019. Rab5ip. 1 hit.
[Graphical view]
ProtoNetSearch...

Other Resources

NextBio61397.

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Entry information

Entry nameCT024_HUMAN
AccessionPrimary (citable) accession number: Q9BUV8
Secondary accession number(s): O00605 expand/collapse secondary AC list , Q9BT03, Q9BZU7, Q9UI05
Entry history
Integrated into UniProtKB/Swiss-Prot: October 19, 2002
Last sequence update: June 1, 2001
Last modified: July 7, 2009
This is version 56 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHPI (Human Proteome Initiative)

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Relevant documents

Human chromosome 20

Human chromosome 20: entries, gene names and cross-references to MIM

Names and origin · Protein attributes · Ontologies · Binary interactions · Alternative products · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents