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Q9BUV8 (CT024_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 99. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Uncharacterized protein C20orf24
Alternative name(s):
Rab5-interacting protein
Short name=RIP5
Gene names
Name:C20orf24
ORF Names:PNAS-11
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length137 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

Ontologies

Keywords
   Coding sequence diversityAlternative splicing
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
None. [Check GOA]

Alternative products

This entry describes 5 isoforms produced by alternative splicing. [Align] [Select]

Note: Experimental confirmation may be lacking for some isoforms.
Isoform 1 (identifier: Q9BUV8-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q9BUV8-2)

The sequence of this isoform differs from the canonical sequence as follows:
     118-137: CVADSFTTGHLDHLLHCHPL → IWIIFYTAIHYD
Isoform 3 (identifier: Q9BUV8-3)

The sequence of this isoform differs from the canonical sequence as follows:
     118-127: CVADSFTTGH → I
Isoform 4 (identifier: Q9BUV8-4)

The sequence of this isoform differs from the canonical sequence as follows:
     74-137: FCLINAGVLY...LDHLLHCHPL → KGHCCSGAVCVCDD
Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.
Isoform 5 (identifier: Q9BUV8-5)

The sequence of this isoform differs from the canonical sequence as follows:
     74-137: FCLINAGVLY...LDHLLHCHPL → SFGSSFTLPS...ASVFSARVVT
Note: Gene prediction based on EST data.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 137137Uncharacterized protein C20orf24
PRO_0000079415

Natural variations

Alternative sequence74 – 13764FCLIN…HCHPL → KGHCCSGAVCVCDD in isoform 4.
VSP_003795
Alternative sequence74 – 13764FCLIN…HCHPL → SFGSSFTLPSIMTDGVQLPS APYPVQRTLLITAQELDRWG TPAPWNLEDPCFLDRESVCW ASVFSARVVT in isoform 5.
VSP_047233
Alternative sequence118 – 13720CVADS…HCHPL → IWIIFYTAIHYD in isoform 2.
VSP_003796
Alternative sequence118 – 12710CVADSFTTGH → I in isoform 3.
VSP_003797

Experimental info

Sequence conflict15 – 3319LANGA…LRSDA → PWANGASKSPSGVRCCGRR in AAB50849. Ref.6
Sequence conflict95 – 1006EEYGGT → GRILVAR in AAK07515. Ref.2
Sequence conflict1001T → Q in AAB50849. Ref.6
Sequence conflict1101T → P in AAB50849. Ref.6
Sequence conflict114 – 13724LFMVC…HCHPL → IVHGHLLLLFTSHPYSMMVS DSK in AAB50849. Ref.6
Sequence conflict1371L → FIT in AAK07515. Ref.2

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified June 1, 2001. Version 1.
Checksum: 4DC7A8E5D61B4C57

FASTA13715,487
        10         20         30         40         50         60 
MSGGRRKEEP PQPQLANGAL KVSVWSKVLR SDAAWEDKDE FLDVIYWFRQ IIAVVLGVIW 

        70         80         90        100        110        120 
GVLPLRGFLG IAGFCLINAG VLYLYFSNYL QIDEEEYGGT WELTKEGFMT SFALFMVCVA 

       130 
DSFTTGHLDH LLHCHPL 

« Hide

Isoform 2 [UniParc].

Checksum: DA8C4AC79B9AFD22
Show »

FASTA12914,825
Isoform 3 [UniParc].

Checksum: BB48F128EAA15C26
Show »

FASTA12814,581
Isoform 4 [UniParc].

Checksum: 77A8B6359FD3660A
Show »

FASTA879,530
Isoform 5 [UniParc].

Checksum: 51AE78E40CF4F979
Show »

FASTA14315,893

References

« Hide 'large scale' references
[1]"A novel gene expressed in human adrenal gland."
Jiang C., Zhang C., Huang C., Peng Y., Gu Y., Zhang L., Wu T., Li Y., Han Z., Wang Y., Chen Z., Fu G.
Submitted (DEC-1998) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
Tissue: Adrenal gland.
[2]"Human acute promyelocytic leukemia cell line NB4's apoptosis related genes."
Yu W.-Q., Sun B.-Z., Chai Y.-B., Zhu F., Liu X.-S., Li Z., Lu F., Yan W., Yang H., Zhao Z.-L.
Submitted (JUN-2000) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
Tissue: Promyelocytic leukemia.
[3]"The DNA sequence and comparative analysis of human chromosome 20."
Deloukas P., Matthews L.H., Ashurst J.L., Burton J., Gilbert J.G.R., Jones M., Stavrides G., Almeida J.P., Babbage A.K., Bagguley C.L., Bailey J., Barlow K.F., Bates K.N., Beard L.M., Beare D.M., Beasley O.P., Bird C.P., Blakey S.E. expand/collapse author list , Bridgeman A.M., Brown A.J., Buck D., Burrill W.D., Butler A.P., Carder C., Carter N.P., Chapman J.C., Clamp M., Clark G., Clark L.N., Clark S.Y., Clee C.M., Clegg S., Cobley V.E., Collier R.E., Connor R.E., Corby N.R., Coulson A., Coville G.J., Deadman R., Dhami P.D., Dunn M., Ellington A.G., Frankland J.A., Fraser A., French L., Garner P., Grafham D.V., Griffiths C., Griffiths M.N.D., Gwilliam R., Hall R.E., Hammond S., Harley J.L., Heath P.D., Ho S., Holden J.L., Howden P.J., Huckle E., Hunt A.R., Hunt S.E., Jekosch K., Johnson C.M., Johnson D., Kay M.P., Kimberley A.M., King A., Knights A., Laird G.K., Lawlor S., Lehvaeslaiho M.H., Leversha M.A., Lloyd C., Lloyd D.M., Lovell J.D., Marsh V.L., Martin S.L., McConnachie L.J., McLay K., McMurray A.A., Milne S.A., Mistry D., Moore M.J.F., Mullikin J.C., Nickerson T., Oliver K., Parker A., Patel R., Pearce T.A.V., Peck A.I., Phillimore B.J.C.T., Prathalingam S.R., Plumb R.W., Ramsay H., Rice C.M., Ross M.T., Scott C.E., Sehra H.K., Shownkeen R., Sims S., Skuce C.D., Smith M.L., Soderlund C., Steward C.A., Sulston J.E., Swann R.M., Sycamore N., Taylor R., Tee L., Thomas D.W., Thorpe A., Tracey A., Tromans A.C., Vaudin M., Wall M., Wallis J.M., Whitehead S.L., Whittaker P., Willey D.L., Williams L., Williams S.A., Wilming L., Wray P.W., Hubbard T., Durbin R.M., Bentley D.R., Beck S., Rogers J.
Nature 414:865-871(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 4).
Tissue: Lung and Skin.
[6]"The GDP/GTP cycle of Rab5 in the regulation of endocytotic membrane traffic."
Vitale G., Alexandrov K., Ullrich O., Horiuchi H., Giner A., Dobson C., Baykova O., Gournier H., Stenmark H., Zerial M.
Cold Spring Harb. Symp. Quant. Biol. 60:211-220(1995) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 15-137 (ISOFORM 1).
[7]"An unappreciated role for RNA surveillance."
Hillman R.T., Green R.E., Brenner S.E.
Genome Biol. 5:R8.1-R8.16(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: SPLICE ISOFORM(S) THAT ARE POTENTIAL NMD TARGET(S).
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF112213 mRNA. Translation: AAF17201.1.
AF274936 mRNA. Translation: AAK07515.1.
AL050318 Genomic DNA. Translation: CAB75367.1.
AL050318 Genomic DNA. Translation: CAI23511.1.
CH471077 Genomic DNA. Translation: EAW76122.1.
CH471077 Genomic DNA. Translation: EAW76120.1.
CH471077 Genomic DNA. Translation: EAW76123.1.
CH471077 Genomic DNA. Translation: EAW76124.1.
BC001871 mRNA. Translation: AAH01871.1.
BC004446 mRNA. Translation: AAH04446.1.
S83364 mRNA. Translation: AAB50849.1.
CCDSCCDS13279.1. [Q9BUV8-5]
CCDS13280.1. [Q9BUV8-2]
CCDS56190.1. [Q9BUV8-1]
RefSeqNP_001186463.1. NM_001199534.1. [Q9BUV8-1]
NP_061328.1. NM_018840.4. [Q9BUV8-2]
NP_955777.1. NM_199483.2. [Q9BUV8-5]
UniGeneHs.584985.

3D structure databases

ProteinModelPortalQ9BUV8.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid121015. 24 interactions.
IntActQ9BUV8. 1 interaction.
STRING9606.ENSP00000341213.

PTM databases

PhosphoSiteQ9BUV8.

Polymorphism databases

DMDM24211596.

Proteomic databases

MaxQBQ9BUV8.
PaxDbQ9BUV8.
PRIDEQ9BUV8.

Protocols and materials databases

DNASU55969.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000342422; ENSP00000341213; ENSG00000101084. [Q9BUV8-5]
ENST00000344795; ENSP00000340164; ENSG00000101084. [Q9BUV8-2]
ENST00000373852; ENSP00000362958; ENSG00000101084. [Q9BUV8-1]
ENST00000483815; ENSP00000432510; ENSG00000101084. [Q9BUV8-4]
ENST00000492721; ENSP00000435871; ENSG00000101084. [Q9BUV8-4]
GeneID55969.
KEGGhsa:55969.
UCSCuc002xfq.3. human. [Q9BUV8-2]
uc002xfs.3. human. [Q9BUV8-1]

Organism-specific databases

CTD55969.
GeneCardsGC20P035234.
HGNCHGNC:15870. C20orf24.
HPAHPA057387.
neXtProtNX_Q9BUV8.
PharmGKBPA25740.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG311375.
HOVERGENHBG051153.
OMADHLLHCH.
OrthoDBEOG7W6WNG.
PhylomeDBQ9BUV8.

Gene expression databases

BgeeQ9BUV8.
CleanExHS_C20orf24.
GenevestigatorQ9BUV8.

Family and domain databases

InterProIPR010742. Rab5ip.
IPR029008. Rab5IP_fam.
[Graphical view]
PANTHERPTHR12906. PTHR12906. 1 hit.
PfamPF07019. Rab5ip. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GenomeRNAi55969.
NextBio61397.

Entry information

Entry nameCT024_HUMAN
AccessionPrimary (citable) accession number: Q9BUV8
Secondary accession number(s): E1P5U0 expand/collapse secondary AC list , O00605, Q5QPG6, Q5QPG7, Q9BT03, Q9BZU7, Q9UI05
Entry history
Integrated into UniProtKB/Swiss-Prot: October 19, 2002
Last sequence update: June 1, 2001
Last modified: July 9, 2014
This is version 99 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

Human chromosome 20

Human chromosome 20: entries, gene names and cross-references to MIM