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Protein

Uncharacterized protein C20orf24

Gene

C20orf24

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Uncharacterized protein C20orf24
Alternative name(s):
Rab5-interacting protein
Short name:
RIP5
Gene namesi
ORF Names:PNAS-11
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 20

Organism-specific databases

HGNCiHGNC:15870. C20orf24.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA25740.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 137137Uncharacterized protein C20orf24PRO_0000079415Add
BLAST

Proteomic databases

MaxQBiQ9BUV8.
PaxDbiQ9BUV8.
PRIDEiQ9BUV8.

PTM databases

PhosphoSiteiQ9BUV8.

Expressioni

Gene expression databases

BgeeiQ9BUV8.
CleanExiHS_C20orf24.
ExpressionAtlasiQ9BUV8. baseline and differential.
GenevestigatoriQ9BUV8.

Organism-specific databases

HPAiHPA057387.

Interactioni

Protein-protein interaction databases

BioGridi121015. 25 interactions.
IntActiQ9BUV8. 1 interaction.
STRINGi9606.ENSP00000341213.

Structurei

3D structure databases

ProteinModelPortaliQ9BUV8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

eggNOGiNOG311375.
GeneTreeiENSGT00390000004786.
HOVERGENiHBG051153.
InParanoidiQ9BUV8.
OMAiDHLLHCH.
OrthoDBiEOG7W6WNG.
PhylomeDBiQ9BUV8.

Family and domain databases

InterProiIPR010742. Rab5ip.
IPR029008. Rab5IP_fam.
[Graphical view]
PANTHERiPTHR12906. PTHR12906. 1 hit.
PfamiPF07019. Rab5ip. 1 hit.
[Graphical view]

Sequences (5)i

Sequence statusi: Complete.

This entry describes 5 isoformsi produced by alternative splicing. Align

Note: Experimental confirmation may be lacking for some isoforms.

Isoform 1 (identifier: Q9BUV8-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSGGRRKEEP PQPQLANGAL KVSVWSKVLR SDAAWEDKDE FLDVIYWFRQ
60 70 80 90 100
IIAVVLGVIW GVLPLRGFLG IAGFCLINAG VLYLYFSNYL QIDEEEYGGT
110 120 130
WELTKEGFMT SFALFMVCVA DSFTTGHLDH LLHCHPL
Length:137
Mass (Da):15,487
Last modified:June 1, 2001 - v1
Checksum:i4DC7A8E5D61B4C57
GO
Isoform 2 (identifier: Q9BUV8-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     118-137: CVADSFTTGHLDHLLHCHPL → IWIIFYTAIHYD

Show »
Length:129
Mass (Da):14,825
Checksum:iDA8C4AC79B9AFD22
GO
Isoform 3 (identifier: Q9BUV8-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     118-127: CVADSFTTGH → I

Show »
Length:128
Mass (Da):14,581
Checksum:iBB48F128EAA15C26
GO
Isoform 4 (identifier: Q9BUV8-4) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     74-137: FCLINAGVLY...LDHLLHCHPL → KGHCCSGAVCVCDD

Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.

Show »
Length:87
Mass (Da):9,530
Checksum:i77A8B6359FD3660A
GO
Isoform 5 (identifier: Q9BUV8-5) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     74-137: FCLINAGVLY...LDHLLHCHPL → SFGSSFTLPS...ASVFSARVVT

Note: Gene prediction based on EST data.

Show »
Length:143
Mass (Da):15,893
Checksum:i51AE78E40CF4F979
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti15 – 3319LANGA…LRSDA → PWANGASKSPSGVRCCGRR in AAB50849. (PubMed:8824393)CuratedAdd
BLAST
Sequence conflicti95 – 1006EEYGGT → GRILVAR in AAK07515. 1 PublicationCurated
Sequence conflicti100 – 1001T → Q in AAB50849. (PubMed:8824393)Curated
Sequence conflicti110 – 1101T → P in AAB50849. (PubMed:8824393)Curated
Sequence conflicti114 – 13724LFMVC…HCHPL → IVHGHLLLLFTSHPYSMMVS DSK in AAB50849. (PubMed:8824393)CuratedAdd
BLAST
Sequence conflicti137 – 1371L → FIT in AAK07515. 1 PublicationCurated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei74 – 13764FCLIN…HCHPL → KGHCCSGAVCVCDD in isoform 4. 1 PublicationVSP_003795Add
BLAST
Alternative sequencei74 – 13764FCLIN…HCHPL → SFGSSFTLPSIMTDGVQLPS APYPVQRTLLITAQELDRWG TPAPWNLEDPCFLDRESVCW ASVFSARVVT in isoform 5. CuratedVSP_047233Add
BLAST
Alternative sequencei118 – 13720CVADS…HCHPL → IWIIFYTAIHYD in isoform 2. 1 PublicationVSP_003796Add
BLAST
Alternative sequencei118 – 12710CVADSFTTGH → I in isoform 3. 1 PublicationVSP_003797

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF112213 mRNA. Translation: AAF17201.1.
AF274936 mRNA. Translation: AAK07515.1.
AL050318 Genomic DNA. Translation: CAB75367.1.
AL050318 Genomic DNA. Translation: CAI23511.1.
CH471077 Genomic DNA. Translation: EAW76122.1.
CH471077 Genomic DNA. Translation: EAW76120.1.
CH471077 Genomic DNA. Translation: EAW76123.1.
CH471077 Genomic DNA. Translation: EAW76124.1.
BC001871 mRNA. Translation: AAH01871.1.
BC004446 mRNA. Translation: AAH04446.1.
S83364 mRNA. Translation: AAB50849.1.
CCDSiCCDS13279.1. [Q9BUV8-5]
CCDS13280.1. [Q9BUV8-2]
CCDS56190.1. [Q9BUV8-1]
RefSeqiNP_001186463.1. NM_001199534.1. [Q9BUV8-1]
NP_061328.1. NM_018840.4. [Q9BUV8-2]
NP_955777.1. NM_199483.2. [Q9BUV8-5]
UniGeneiHs.584985.

Genome annotation databases

EnsembliENST00000342422; ENSP00000341213; ENSG00000101084. [Q9BUV8-5]
ENST00000344795; ENSP00000340164; ENSG00000101084. [Q9BUV8-2]
ENST00000373852; ENSP00000362958; ENSG00000101084. [Q9BUV8-1]
ENST00000483815; ENSP00000432510; ENSG00000101084. [Q9BUV8-4]
ENST00000492721; ENSP00000435871; ENSG00000101084. [Q9BUV8-4]
GeneIDi55969.
KEGGihsa:55969.
UCSCiuc002xfq.3. human. [Q9BUV8-2]
uc002xfr.3. human.
uc002xfs.3. human. [Q9BUV8-1]

Polymorphism databases

DMDMi24211596.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF112213 mRNA. Translation: AAF17201.1.
AF274936 mRNA. Translation: AAK07515.1.
AL050318 Genomic DNA. Translation: CAB75367.1.
AL050318 Genomic DNA. Translation: CAI23511.1.
CH471077 Genomic DNA. Translation: EAW76122.1.
CH471077 Genomic DNA. Translation: EAW76120.1.
CH471077 Genomic DNA. Translation: EAW76123.1.
CH471077 Genomic DNA. Translation: EAW76124.1.
BC001871 mRNA. Translation: AAH01871.1.
BC004446 mRNA. Translation: AAH04446.1.
S83364 mRNA. Translation: AAB50849.1.
CCDSiCCDS13279.1. [Q9BUV8-5]
CCDS13280.1. [Q9BUV8-2]
CCDS56190.1. [Q9BUV8-1]
RefSeqiNP_001186463.1. NM_001199534.1. [Q9BUV8-1]
NP_061328.1. NM_018840.4. [Q9BUV8-2]
NP_955777.1. NM_199483.2. [Q9BUV8-5]
UniGeneiHs.584985.

3D structure databases

ProteinModelPortaliQ9BUV8.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi121015. 25 interactions.
IntActiQ9BUV8. 1 interaction.
STRINGi9606.ENSP00000341213.

PTM databases

PhosphoSiteiQ9BUV8.

Polymorphism databases

DMDMi24211596.

Proteomic databases

MaxQBiQ9BUV8.
PaxDbiQ9BUV8.
PRIDEiQ9BUV8.

Protocols and materials databases

DNASUi55969.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000342422; ENSP00000341213; ENSG00000101084. [Q9BUV8-5]
ENST00000344795; ENSP00000340164; ENSG00000101084. [Q9BUV8-2]
ENST00000373852; ENSP00000362958; ENSG00000101084. [Q9BUV8-1]
ENST00000483815; ENSP00000432510; ENSG00000101084. [Q9BUV8-4]
ENST00000492721; ENSP00000435871; ENSG00000101084. [Q9BUV8-4]
GeneIDi55969.
KEGGihsa:55969.
UCSCiuc002xfq.3. human. [Q9BUV8-2]
uc002xfr.3. human.
uc002xfs.3. human. [Q9BUV8-1]

Organism-specific databases

CTDi55969.
GeneCardsiGC20P035234.
HGNCiHGNC:15870. C20orf24.
HPAiHPA057387.
neXtProtiNX_Q9BUV8.
PharmGKBiPA25740.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG311375.
GeneTreeiENSGT00390000004786.
HOVERGENiHBG051153.
InParanoidiQ9BUV8.
OMAiDHLLHCH.
OrthoDBiEOG7W6WNG.
PhylomeDBiQ9BUV8.

Miscellaneous databases

GenomeRNAii55969.
NextBioi61397.

Gene expression databases

BgeeiQ9BUV8.
CleanExiHS_C20orf24.
ExpressionAtlasiQ9BUV8. baseline and differential.
GenevestigatoriQ9BUV8.

Family and domain databases

InterProiIPR010742. Rab5ip.
IPR029008. Rab5IP_fam.
[Graphical view]
PANTHERiPTHR12906. PTHR12906. 1 hit.
PfamiPF07019. Rab5ip. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "A novel gene expressed in human adrenal gland."
    Jiang C., Zhang C., Huang C., Peng Y., Gu Y., Zhang L., Wu T., Li Y., Han Z., Wang Y., Chen Z., Fu G.
    Submitted (DEC-1998) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
    Tissue: Adrenal gland.
  2. "Human acute promyelocytic leukemia cell line NB4's apoptosis related genes."
    Yu W.-Q., Sun B.-Z., Chai Y.-B., Zhu F., Liu X.-S., Li Z., Lu F., Yan W., Yang H., Zhao Z.-L.
    Submitted (JUN-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
    Tissue: Promyelocytic leukemia.
  3. "The DNA sequence and comparative analysis of human chromosome 20."
    Deloukas P., Matthews L.H., Ashurst J.L., Burton J., Gilbert J.G.R., Jones M., Stavrides G., Almeida J.P., Babbage A.K., Bagguley C.L., Bailey J., Barlow K.F., Bates K.N., Beard L.M., Beare D.M., Beasley O.P., Bird C.P., Blakey S.E.
    , Bridgeman A.M., Brown A.J., Buck D., Burrill W.D., Butler A.P., Carder C., Carter N.P., Chapman J.C., Clamp M., Clark G., Clark L.N., Clark S.Y., Clee C.M., Clegg S., Cobley V.E., Collier R.E., Connor R.E., Corby N.R., Coulson A., Coville G.J., Deadman R., Dhami P.D., Dunn M., Ellington A.G., Frankland J.A., Fraser A., French L., Garner P., Grafham D.V., Griffiths C., Griffiths M.N.D., Gwilliam R., Hall R.E., Hammond S., Harley J.L., Heath P.D., Ho S., Holden J.L., Howden P.J., Huckle E., Hunt A.R., Hunt S.E., Jekosch K., Johnson C.M., Johnson D., Kay M.P., Kimberley A.M., King A., Knights A., Laird G.K., Lawlor S., Lehvaeslaiho M.H., Leversha M.A., Lloyd C., Lloyd D.M., Lovell J.D., Marsh V.L., Martin S.L., McConnachie L.J., McLay K., McMurray A.A., Milne S.A., Mistry D., Moore M.J.F., Mullikin J.C., Nickerson T., Oliver K., Parker A., Patel R., Pearce T.A.V., Peck A.I., Phillimore B.J.C.T., Prathalingam S.R., Plumb R.W., Ramsay H., Rice C.M., Ross M.T., Scott C.E., Sehra H.K., Shownkeen R., Sims S., Skuce C.D., Smith M.L., Soderlund C., Steward C.A., Sulston J.E., Swann R.M., Sycamore N., Taylor R., Tee L., Thomas D.W., Thorpe A., Tracey A., Tromans A.C., Vaudin M., Wall M., Wallis J.M., Whitehead S.L., Whittaker P., Willey D.L., Williams L., Williams S.A., Wilming L., Wray P.W., Hubbard T., Durbin R.M., Bentley D.R., Beck S., Rogers J.
    Nature 414:865-871(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 4).
    Tissue: Lung and Skin.
  6. "The GDP/GTP cycle of Rab5 in the regulation of endocytotic membrane traffic."
    Vitale G., Alexandrov K., Ullrich O., Horiuchi H., Giner A., Dobson C., Baykova O., Gournier H., Stenmark H., Zerial M.
    Cold Spring Harb. Symp. Quant. Biol. 60:211-220(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 15-137 (ISOFORM 1).
  7. Cited for: SPLICE ISOFORM(S) THAT ARE POTENTIAL NMD TARGET(S).

Entry informationi

Entry nameiCT024_HUMAN
AccessioniPrimary (citable) accession number: Q9BUV8
Secondary accession number(s): E1P5U0
, O00605, Q5QPG6, Q5QPG7, Q9BT03, Q9BZU7, Q9UI05
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 19, 2002
Last sequence update: June 1, 2001
Last modified: January 7, 2015
This is version 103 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 20
    Human chromosome 20: entries, gene names and cross-references to MIM

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.