ID RSRP1_HUMAN Reviewed; 290 AA. AC Q9BUV0; A8K917; Q49AA4; Q5TH71; Q9GZP6; DT 21-AUG-2007, integrated into UniProtKB/Swiss-Prot. DT 21-AUG-2007, sequence version 2. DT 27-MAR-2024, entry version 141. DE RecName: Full=Arginine/serine-rich protein 1; GN Name=RSRP1 {ECO:0000312|HGNC:HGNC:25234}; Synonyms=C1orf63; GN ORFNames=HT033, NPD014; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; OC Homo. OX NCBI_TaxID=9606; RN [1] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2). RC TISSUE=Embryo, and Testis; RX PubMed=14702039; DOI=10.1038/ng1285; RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S., RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., RA Isogai T., Sugano S.; RT "Complete sequencing and characterization of 21,243 full-length human RT cDNAs."; RL Nat. Genet. 36:40-45(2004). RN [2] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2). RC TISSUE=Pituitary; RA Song H., Gao G., Peng Y., Ren S., Chen Z., Han Z.; RT "A novel gene expressed in the human pituitary gland."; RL Submitted (MAR-2000) to the EMBL/GenBank/DDBJ databases. RN [3] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2). RC TISSUE=Hypothalamus; RA Xu X., Yang Y., Gao G., Xiao H., Chen Z., Han Z.; RL Submitted (JAN-2001) to the EMBL/GenBank/DDBJ databases. RN [4] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=16710414; DOI=10.1038/nature04727; RA Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., RA Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., RA Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K., RA Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., RA Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., RA Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., RA Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., RA Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., RA Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., RA Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., RA Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., RA Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., RA Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., RA Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., RA Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., RA Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., RA Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., RA Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., RA Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., RA McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., RA Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., RA Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., RA Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., RA Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., RA Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., RA White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., RA Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., RA Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., RA Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.; RT "The DNA sequence and biological annotation of human chromosome 1."; RL Nature 441:315-321(2006). RN [5] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., RA Hunkapiller M.W., Myers E.W., Venter J.C.; RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases. RN [6] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 3), AND VARIANT RP GLY-239. RC TISSUE=Lung, Skin, and Testis; RX PubMed=15489334; DOI=10.1101/gr.2596504; RG The MGC Project Team; RT "The status, quality, and expansion of the NIH full-length cDNA project: RT the Mammalian Gene Collection (MGC)."; RL Genome Res. 14:2121-2127(2004). RN [7] RP FUNCTION, TISSUE SPECIFICITY, SUBCELLULAR LOCATION, MUTAGENESIS OF RP 107-SER--SER-109; SER-107 AND SER-109, AND PHOSPHORYLATION AT SER-107 AND RP SER-109. RX PubMed=34042961; DOI=10.1093/neuonc/noab126; RA Li Y., Wang X., Qi S., Gao L., Huang G., Ren Z., Li K., Peng Y., Yi G., RA Guo J., Yang R., Wang H., Zhang X., Liu Y.; RT "Spliceosome-regulated RSRP1-dependent NF-kappaB activation promotes the RT glioblastoma mesenchymal phenotype."; RL Neuro-oncol. 23:1693-1708(2021). CC -!- FUNCTION: Probably acts as a spliceosomal factor that contributes to CC spliceosome assembly and regulates the isoform switching of proteins CC such as PARP6. {ECO:0000269|PubMed:34042961}. CC -!- INTERACTION: CC Q9BUV0; Q9UK58: CCNL1; NbExp=3; IntAct=EBI-745604, EBI-2836773; CC Q9BUV0; P49760: CLK2; NbExp=13; IntAct=EBI-745604, EBI-750020; CC Q9BUV0; P49761: CLK3; NbExp=11; IntAct=EBI-745604, EBI-745579; CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:34042961}. CC -!- ALTERNATIVE PRODUCTS: CC Event=Alternative splicing; Named isoforms=3; CC Name=1; CC IsoId=Q9BUV0-1; Sequence=Displayed; CC Name=2; CC IsoId=Q9BUV0-2; Sequence=VSP_027305; CC Name=3; CC IsoId=Q9BUV0-3; Sequence=VSP_027306, VSP_027307; CC -!- TISSUE SPECIFICITY: Expressed in brain (at protein level). CC {ECO:0000269|PubMed:34042961}. CC -!- PTM: Phosphorylated. Phosphorylation at Ser-107 and Ser-109 mediates CC the interaction with spliceosome proteins. CC {ECO:0000269|PubMed:34042961}. CC -!- MISCELLANEOUS: [Isoform 3]: May be produced at very low levels due to a CC premature stop codon in the mRNA, leading to nonsense-mediated mRNA CC decay. {ECO:0000305}. CC -!- SIMILARITY: Belongs to the RSRP family. {ECO:0000305}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AK027318; BAB55038.1; -; mRNA. DR EMBL; AK292532; BAF85221.1; -; mRNA. DR EMBL; AF247168; AAG44543.1; -; mRNA. DR EMBL; AF267856; AAG44725.1; -; mRNA. DR EMBL; AL031432; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; CH471134; EAW95157.1; -; Genomic_DNA. DR EMBL; BC001892; AAH01892.1; -; mRNA. DR EMBL; BC041843; AAH41843.1; -; mRNA. DR EMBL; BC065040; AAH65040.1; -; mRNA. DR CCDS; CCDS260.1; -. [Q9BUV0-1] DR RefSeq; NP_001308701.1; NM_001321772.1. [Q9BUV0-1] DR RefSeq; NP_064713.3; NM_020317.4. [Q9BUV0-1] DR RefSeq; XP_011540099.1; XM_011541797.1. DR AlphaFoldDB; Q9BUV0; -. DR SMR; Q9BUV0; -. DR BioGRID; 121332; 27. DR IntAct; Q9BUV0; 22. DR MINT; Q9BUV0; -. DR STRING; 9606.ENSP00000243189; -. DR GlyGen; Q9BUV0; 1 site, 1 O-linked glycan (1 site). DR iPTMnet; Q9BUV0; -. DR PhosphoSitePlus; Q9BUV0; -. DR BioMuta; RSRP1; -. DR DMDM; 156630464; -. DR MassIVE; Q9BUV0; -. DR MaxQB; Q9BUV0; -. DR PaxDb; 9606-ENSP00000243189; -. DR PeptideAtlas; Q9BUV0; -. DR ProteomicsDB; 79133; -. [Q9BUV0-1] DR ProteomicsDB; 79134; -. [Q9BUV0-2] DR ProteomicsDB; 79135; -. [Q9BUV0-3] DR Antibodypedia; 30373; 86 antibodies from 15 providers. DR DNASU; 57035; -. DR Ensembl; ENST00000243189.12; ENSP00000243189.7; ENSG00000117616.18. [Q9BUV0-1] DR Ensembl; ENST00000431849.3; ENSP00000391510.3; ENSG00000117616.18. [Q9BUV0-2] DR Ensembl; ENST00000473314.6; ENSP00000457582.1; ENSG00000117616.18. [Q9BUV0-3] DR GeneID; 57035; -. DR KEGG; hsa:57035; -. DR MANE-Select; ENST00000243189.12; ENSP00000243189.7; NM_020317.5; NP_064713.3. DR UCSC; uc001bjw.4; human. [Q9BUV0-1] DR AGR; HGNC:25234; -. DR CTD; 57035; -. DR DisGeNET; 57035; -. DR GeneCards; RSRP1; -. DR HGNC; HGNC:25234; RSRP1. DR HPA; ENSG00000117616; Low tissue specificity. DR MIM; 620030; gene. DR neXtProt; NX_Q9BUV0; -. DR OpenTargets; ENSG00000117616; -. DR PharmGKB; PA142672513; -. DR VEuPathDB; HostDB:ENSG00000117616; -. DR eggNOG; ENOG502S6J6; Eukaryota. DR GeneTree; ENSGT00730000111390; -. DR HOGENOM; CLU_058639_0_0_1; -. DR InParanoid; Q9BUV0; -. DR OMA; YPRCHRR; -. DR OrthoDB; 5362733at2759; -. DR PhylomeDB; Q9BUV0; -. DR TreeFam; TF338669; -. DR PathwayCommons; Q9BUV0; -. DR SignaLink; Q9BUV0; -. DR BioGRID-ORCS; 57035; 15 hits in 1152 CRISPR screens. DR ChiTaRS; RSRP1; human. DR GenomeRNAi; 57035; -. DR Pharos; Q9BUV0; Tdark. DR PRO; PR:Q9BUV0; -. DR Proteomes; UP000005640; Chromosome 1. DR RNAct; Q9BUV0; Protein. DR Bgee; ENSG00000117616; Expressed in germinal epithelium of ovary and 208 other cell types or tissues. DR ExpressionAtlas; Q9BUV0; baseline and differential. DR GO; GO:0005634; C:nucleus; IDA:UniProtKB. DR GO; GO:0000245; P:spliceosomal complex assembly; IDA:UniProtKB. DR InterPro; IPR029656; RSRP1. DR PANTHER; PTHR47622; ARGININE/SERINE-RICH PROTEIN 1; 1. DR PANTHER; PTHR47622:SF1; ARGININE_SERINE-RICH PROTEIN 1; 1. DR Pfam; PF17069; RSRP; 1. DR Genevisible; Q9BUV0; HS. PE 1: Evidence at protein level; KW Alternative splicing; Methylation; Nucleus; Phosphoprotein; KW Reference proteome. FT CHAIN 1..290 FT /note="Arginine/serine-rich protein 1" FT /id="PRO_0000297617" FT REGION 1..125 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT REGION 150..169 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT REGION 204..290 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 1..50 FT /note="Polar residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 51..99 FT /note="Basic residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 107..123 FT /note="Basic residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 236..269 FT /note="Polar residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT MOD_RES 12 FT /note="Phosphoserine" FT /evidence="ECO:0000250|UniProtKB:Q3UC65" FT MOD_RES 107 FT /note="Phosphoserine" FT /evidence="ECO:0000305|PubMed:34042961" FT MOD_RES 109 FT /note="Phosphoserine" FT /evidence="ECO:0000305|PubMed:34042961" FT MOD_RES 135 FT /note="Omega-N-methylarginine" FT /evidence="ECO:0000250|UniProtKB:Q3UC65" FT MOD_RES 274 FT /note="Phosphoserine" FT /evidence="ECO:0000250|UniProtKB:Q5U2S0" FT VAR_SEQ 225..290 FT /note="LSEKVTEDGTRNPNEKPTQQRSIAFSSNNSVAKPIQKSAKAATEEASSRSPK FT IDQKKSPYGLWIPI -> VSILGLSEQNFQKANCQI (in isoform 2)" FT /evidence="ECO:0000303|PubMed:14702039, ECO:0000303|Ref.2, FT ECO:0000303|Ref.3" FT /id="VSP_027305" FT VAR_SEQ 225..226 FT /note="LS -> KS (in isoform 3)" FT /evidence="ECO:0000303|PubMed:15489334" FT /id="VSP_027306" FT VAR_SEQ 227..290 FT /note="Missing (in isoform 3)" FT /evidence="ECO:0000303|PubMed:15489334" FT /id="VSP_027307" FT VARIANT 147 FT /note="Y -> H (in dbSNP:rs34619962)" FT /id="VAR_034655" FT VARIANT 239 FT /note="E -> G (in dbSNP:rs1043879)" FT /evidence="ECO:0000269|PubMed:15489334" FT /id="VAR_034656" FT MUTAGEN 107..109 FT /note="SPS->APA: Reduces interaction with spliceosome FT factors." FT /evidence="ECO:0000269|PubMed:34042961" FT MUTAGEN 107 FT /note="S->A: No effect on interaction with spliceosome FT factors." FT /evidence="ECO:0000269|PubMed:34042961" FT MUTAGEN 109 FT /note="S->A: No effect on interaction with spliceosome FT factors." FT /evidence="ECO:0000269|PubMed:34042961" SQ SEQUENCE 290 AA; 33613 MW; E729EA9895672216 CRC64; MSNYVNDMWP GSPQEKDSPS TSRSGGSSRL SSRSRSRSFS RSSRSHSRVS SRFSSRSRRS KSRSRSRRRH QRKYRRYSRS YSRSRSRSRS RRYRERRYGF TRRYYRSPSR YRSRSRSRSR SRGRSYCGRA YAIARGQRYY GFGRTVYPEE HSRWRDRSRT RSRSRTPFRL SEKDRMELLE IAKTNAAKAL GTTNIDLPAS LRTVPSAKET SRGIGVSSNG AKPELSEKVT EDGTRNPNEK PTQQRSIAFS SNNSVAKPIQ KSAKAATEEA SSRSPKIDQK KSPYGLWIPI //