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Q9BUV0 (RSRP1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 80. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (4) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Arginine/serine-rich protein 1
Gene names
Name:RSRP1
Synonyms:C1orf63
ORF Names:HT033, NPD014
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length290 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Sequence similarities

Belongs to the RSRP family.

Ontologies

Keywords
   Coding sequence diversityAlternative splicing
Polymorphism
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
None. [Check GOA]

Alternative products

This entry describes 3 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q9BUV0-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Note: No experimental confirmation available.
Isoform 2 (identifier: Q9BUV0-2)

The sequence of this isoform differs from the canonical sequence as follows:
     225-290: LSEKVTEDGT...KSPYGLWIPI → VSILGLSEQNFQKANCQI
Isoform 3 (identifier: Q9BUV0-3)

The sequence of this isoform differs from the canonical sequence as follows:
     225-226: LS → KS
     227-290: Missing.
Note: No experimental confirmation available. May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 290290Arginine/serine-rich protein 1
PRO_0000297617

Regions

Compositional bias18 – 169152Arg/Ser-rich

Natural variations

Alternative sequence225 – 29066LSEKV…LWIPI → VSILGLSEQNFQKANCQI in isoform 2.
VSP_027305
Alternative sequence225 – 2262LS → KS in isoform 3.
VSP_027306
Alternative sequence227 – 29064Missing in isoform 3.
VSP_027307
Natural variant1471Y → H.
Corresponds to variant rs34619962 [ dbSNP | Ensembl ].
VAR_034655
Natural variant2391E → G. Ref.6
Corresponds to variant rs1043879 [ dbSNP | Ensembl ].
VAR_034656

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified August 21, 2007. Version 2.
Checksum: E729EA9895672216

FASTA29033,613
        10         20         30         40         50         60 
MSNYVNDMWP GSPQEKDSPS TSRSGGSSRL SSRSRSRSFS RSSRSHSRVS SRFSSRSRRS 

        70         80         90        100        110        120 
KSRSRSRRRH QRKYRRYSRS YSRSRSRSRS RRYRERRYGF TRRYYRSPSR YRSRSRSRSR 

       130        140        150        160        170        180 
SRGRSYCGRA YAIARGQRYY GFGRTVYPEE HSRWRDRSRT RSRSRTPFRL SEKDRMELLE 

       190        200        210        220        230        240 
IAKTNAAKAL GTTNIDLPAS LRTVPSAKET SRGIGVSSNG AKPELSEKVT EDGTRNPNEK 

       250        260        270        280        290 
PTQQRSIAFS SNNSVAKPIQ KSAKAATEEA SSRSPKIDQK KSPYGLWIPI 

« Hide

Isoform 2 [UniParc].

Checksum: CCB829DCFDE406A4
Show »

FASTA24228,364
Isoform 3 [UniParc].

Checksum: FA6252B925D84FDC
Show »

FASTA22626,605

References

[1]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
Tissue: Embryo and Testis.
[2]"A novel gene expressed in the human pituitary gland."
Song H., Gao G., Peng Y., Ren S., Chen Z., Han Z.
Submitted (MAR-2000) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
Tissue: Pituitary.
[3]Xu X., Yang Y., Gao G., Xiao H., Chen Z., Han Z.
Submitted (JAN-2001) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
Tissue: Hypothalamus.
[4]"The DNA sequence and biological annotation of human chromosome 1."
Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K. expand/collapse author list , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[6]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 3), VARIANT GLY-239.
Tissue: Lung, Skin and Testis.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AK027318 mRNA. Translation: BAB55038.1.
AK292532 mRNA. Translation: BAF85221.1.
AF247168 mRNA. Translation: AAG44543.1.
AF267856 mRNA. Translation: AAG44725.1.
AL031432 Genomic DNA. Translation: CAB37992.1.
CH471134 Genomic DNA. Translation: EAW95157.1.
BC001892 mRNA. Translation: AAH01892.1.
BC041843 mRNA. Translation: AAH41843.1.
BC065040 mRNA. Translation: AAH65040.1.
RefSeqNP_064713.3. NM_020317.3.
UniGeneHs.259412.

3D structure databases

ProteinModelPortalQ9BUV0.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid121332. 6 interactions.
IntActQ9BUV0. 6 interactions.
MINTMINT-1448691.
STRING9606.ENSP00000243189.

PTM databases

PhosphoSiteQ9BUV0.

Polymorphism databases

DMDM156630464.

Proteomic databases

PaxDbQ9BUV0.
PRIDEQ9BUV0.

Protocols and materials databases

DNASU57035.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000243189; ENSP00000243189; ENSG00000117616. [Q9BUV0-1]
ENST00000431849; ENSP00000391510; ENSG00000117616. [Q9BUV0-3]
ENST00000473314; ENSP00000457582; ENSG00000117616. [Q9BUV0-3]
GeneID57035.
KEGGhsa:57035.
UCSCuc001bjw.3. human. [Q9BUV0-1]

Organism-specific databases

CTD57035.
GeneCardsGC01M025568.
HGNCHGNC:25234. RSRP1.
HPAHPA058992.
neXtProtNX_Q9BUV0.
PharmGKBPA142672513.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG40356.
HOGENOMHOG000111224.
InParanoidQ9BUV0.
OrthoDBEOG7WDN50.
PhylomeDBQ9BUV0.
TreeFamTF338669.

Gene expression databases

ArrayExpressQ9BUV0.
BgeeQ9BUV0.
CleanExHS_C1orf63.
GenevestigatorQ9BUV0.

Family and domain databases

ProtoNetSearch...

Other

GenomeRNAi57035.
NextBio62785.

Entry information

Entry nameRSRP1_HUMAN
AccessionPrimary (citable) accession number: Q9BUV0
Secondary accession number(s): A8K917 expand/collapse secondary AC list , Q49AA4, Q5TH71, Q9GZP6
Entry history
Integrated into UniProtKB/Swiss-Prot: August 21, 2007
Last sequence update: August 21, 2007
Last modified: April 16, 2014
This is version 80 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 1

Human chromosome 1: entries, gene names and cross-references to MIM