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Q9BUV0

- RSRP1_HUMAN

UniProt

Q9BUV0 - RSRP1_HUMAN

Protein

Arginine/serine-rich protein 1

Gene

RSRP1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 84 (01 Oct 2014)
      Sequence version 2 (21 Aug 2007)
      Previous versions | rss
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    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Arginine/serine-rich protein 1
    Gene namesi
    Name:RSRP1
    Synonyms:C1orf63
    ORF Names:HT033, NPD014
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 1

    Organism-specific databases

    HGNCiHGNC:25234. RSRP1.

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA142672513.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 290290Arginine/serine-rich protein 1PRO_0000297617Add
    BLAST

    Proteomic databases

    PaxDbiQ9BUV0.
    PRIDEiQ9BUV0.

    PTM databases

    PhosphoSiteiQ9BUV0.

    Expressioni

    Gene expression databases

    ArrayExpressiQ9BUV0.
    BgeeiQ9BUV0.
    CleanExiHS_C1orf63.
    GenevestigatoriQ9BUV0.

    Organism-specific databases

    HPAiHPA058992.

    Interactioni

    Protein-protein interaction databases

    BioGridi121332. 6 interactions.
    IntActiQ9BUV0. 6 interactions.
    MINTiMINT-1448691.
    STRINGi9606.ENSP00000243189.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9BUV0.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi18 – 169152Arg/Ser-richAdd
    BLAST

    Sequence similaritiesi

    Belongs to the RSRP family.Curated

    Phylogenomic databases

    eggNOGiNOG40356.
    HOGENOMiHOG000111224.
    InParanoidiQ9BUV0.
    OrthoDBiEOG7WDN50.
    PhylomeDBiQ9BUV0.
    TreeFamiTF338669.

    Family and domain databases

    InterProiIPR029656. RSRP1.
    [Graphical view]
    PANTHERiPTHR10548:SF89. PTHR10548:SF89. 1 hit.

    Sequences (3)i

    Sequence statusi: Complete.

    This entry describes 3 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q9BUV0-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MSNYVNDMWP GSPQEKDSPS TSRSGGSSRL SSRSRSRSFS RSSRSHSRVS    50
    SRFSSRSRRS KSRSRSRRRH QRKYRRYSRS YSRSRSRSRS RRYRERRYGF 100
    TRRYYRSPSR YRSRSRSRSR SRGRSYCGRA YAIARGQRYY GFGRTVYPEE 150
    HSRWRDRSRT RSRSRTPFRL SEKDRMELLE IAKTNAAKAL GTTNIDLPAS 200
    LRTVPSAKET SRGIGVSSNG AKPELSEKVT EDGTRNPNEK PTQQRSIAFS 250
    SNNSVAKPIQ KSAKAATEEA SSRSPKIDQK KSPYGLWIPI 290

    Note: No experimental confirmation available.

    Length:290
    Mass (Da):33,613
    Last modified:August 21, 2007 - v2
    Checksum:iE729EA9895672216
    GO
    Isoform 2 (identifier: Q9BUV0-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         225-290: LSEKVTEDGT...KSPYGLWIPI → VSILGLSEQNFQKANCQI

    Show »
    Length:242
    Mass (Da):28,364
    Checksum:iCCB829DCFDE406A4
    GO
    Isoform 3 (identifier: Q9BUV0-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         225-226: LS → KS
         227-290: Missing.

    Note: No experimental confirmation available. May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.

    Show »
    Length:226
    Mass (Da):26,605
    Checksum:iFA6252B925D84FDC
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti147 – 1471Y → H.
    Corresponds to variant rs34619962 [ dbSNP | Ensembl ].
    VAR_034655
    Natural varianti239 – 2391E → G.1 Publication
    Corresponds to variant rs1043879 [ dbSNP | Ensembl ].
    VAR_034656

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei225 – 29066LSEKV…LWIPI → VSILGLSEQNFQKANCQI in isoform 2. 3 PublicationsVSP_027305Add
    BLAST
    Alternative sequencei225 – 2262LS → KS in isoform 3. 1 PublicationVSP_027306
    Alternative sequencei227 – 29064Missing in isoform 3. 1 PublicationVSP_027307Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK027318 mRNA. Translation: BAB55038.1.
    AK292532 mRNA. Translation: BAF85221.1.
    AF247168 mRNA. Translation: AAG44543.1.
    AF267856 mRNA. Translation: AAG44725.1.
    AL031432 Genomic DNA. Translation: CAB37992.1.
    CH471134 Genomic DNA. Translation: EAW95157.1.
    BC001892 mRNA. Translation: AAH01892.1.
    BC041843 mRNA. Translation: AAH41843.1.
    BC065040 mRNA. Translation: AAH65040.1.
    CCDSiCCDS260.1. [Q9BUV0-1]
    RefSeqiNP_064713.3. NM_020317.3. [Q9BUV0-1]
    UniGeneiHs.259412.

    Genome annotation databases

    EnsembliENST00000243189; ENSP00000243189; ENSG00000117616. [Q9BUV0-1]
    ENST00000431849; ENSP00000391510; ENSG00000117616. [Q9BUV0-3]
    ENST00000473314; ENSP00000457582; ENSG00000117616. [Q9BUV0-3]
    GeneIDi57035.
    KEGGihsa:57035.
    UCSCiuc001bjw.3. human. [Q9BUV0-1]

    Polymorphism databases

    DMDMi156630464.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK027318 mRNA. Translation: BAB55038.1 .
    AK292532 mRNA. Translation: BAF85221.1 .
    AF247168 mRNA. Translation: AAG44543.1 .
    AF267856 mRNA. Translation: AAG44725.1 .
    AL031432 Genomic DNA. Translation: CAB37992.1 .
    CH471134 Genomic DNA. Translation: EAW95157.1 .
    BC001892 mRNA. Translation: AAH01892.1 .
    BC041843 mRNA. Translation: AAH41843.1 .
    BC065040 mRNA. Translation: AAH65040.1 .
    CCDSi CCDS260.1. [Q9BUV0-1 ]
    RefSeqi NP_064713.3. NM_020317.3. [Q9BUV0-1 ]
    UniGenei Hs.259412.

    3D structure databases

    ProteinModelPortali Q9BUV0.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 121332. 6 interactions.
    IntActi Q9BUV0. 6 interactions.
    MINTi MINT-1448691.
    STRINGi 9606.ENSP00000243189.

    PTM databases

    PhosphoSitei Q9BUV0.

    Polymorphism databases

    DMDMi 156630464.

    Proteomic databases

    PaxDbi Q9BUV0.
    PRIDEi Q9BUV0.

    Protocols and materials databases

    DNASUi 57035.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000243189 ; ENSP00000243189 ; ENSG00000117616 . [Q9BUV0-1 ]
    ENST00000431849 ; ENSP00000391510 ; ENSG00000117616 . [Q9BUV0-3 ]
    ENST00000473314 ; ENSP00000457582 ; ENSG00000117616 . [Q9BUV0-3 ]
    GeneIDi 57035.
    KEGGi hsa:57035.
    UCSCi uc001bjw.3. human. [Q9BUV0-1 ]

    Organism-specific databases

    CTDi 57035.
    GeneCardsi GC01M025568.
    HGNCi HGNC:25234. RSRP1.
    HPAi HPA058992.
    neXtProti NX_Q9BUV0.
    PharmGKBi PA142672513.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG40356.
    HOGENOMi HOG000111224.
    InParanoidi Q9BUV0.
    OrthoDBi EOG7WDN50.
    PhylomeDBi Q9BUV0.
    TreeFami TF338669.

    Miscellaneous databases

    GenomeRNAii 57035.
    NextBioi 62785.

    Gene expression databases

    ArrayExpressi Q9BUV0.
    Bgeei Q9BUV0.
    CleanExi HS_C1orf63.
    Genevestigatori Q9BUV0.

    Family and domain databases

    InterProi IPR029656. RSRP1.
    [Graphical view ]
    PANTHERi PTHR10548:SF89. PTHR10548:SF89. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
      Tissue: Embryo and Testis.
    2. "A novel gene expressed in the human pituitary gland."
      Song H., Gao G., Peng Y., Ren S., Chen Z., Han Z.
      Submitted (MAR-2000) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
      Tissue: Pituitary.
    3. Xu X., Yang Y., Gao G., Xiao H., Chen Z., Han Z.
      Submitted (JAN-2001) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
      Tissue: Hypothalamus.
    4. "The DNA sequence and biological annotation of human chromosome 1."
      Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
      , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
      Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 3), VARIANT GLY-239.
      Tissue: Lung, Skin and Testis.

    Entry informationi

    Entry nameiRSRP1_HUMAN
    AccessioniPrimary (citable) accession number: Q9BUV0
    Secondary accession number(s): A8K917
    , Q49AA4, Q5TH71, Q9GZP6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: August 21, 2007
    Last sequence update: August 21, 2007
    Last modified: October 1, 2014
    This is version 84 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 1
      Human chromosome 1: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3