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Protein

Arginine/serine-rich protein 1

Gene

RSRP1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Arginine/serine-rich protein 1
Gene namesi
Name:RSRP1
Synonyms:C1orf63
ORF Names:HT033, NPD014
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:25234. RSRP1.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA142672513.

Polymorphism and mutation databases

BioMutaiC1orf63.
DMDMi156630464.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 290290Arginine/serine-rich protein 1PRO_0000297617Add
BLAST

Proteomic databases

MaxQBiQ9BUV0.
PaxDbiQ9BUV0.
PRIDEiQ9BUV0.

PTM databases

PhosphoSiteiQ9BUV0.

Expressioni

Gene expression databases

BgeeiQ9BUV0.
CleanExiHS_C1orf63.
ExpressionAtlasiQ9BUV0. baseline and differential.
GenevestigatoriQ9BUV0.

Organism-specific databases

HPAiHPA058992.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
CLK2P497603EBI-745604,EBI-750020
CLK3P497614EBI-745604,EBI-745579

Protein-protein interaction databases

BioGridi121332. 14 interactions.
IntActiQ9BUV0. 7 interactions.
MINTiMINT-1448691.
STRINGi9606.ENSP00000243189.

Structurei

3D structure databases

ProteinModelPortaliQ9BUV0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi18 – 169152Arg/Ser-richAdd
BLAST

Sequence similaritiesi

Belongs to the RSRP family.Curated

Phylogenomic databases

eggNOGiNOG40356.
GeneTreeiENSGT00730000111390.
HOGENOMiHOG000111224.
InParanoidiQ9BUV0.
OrthoDBiEOG7WDN50.
PhylomeDBiQ9BUV0.
TreeFamiTF338669.

Family and domain databases

InterProiIPR029656. RSRP1.
[Graphical view]
PANTHERiPTHR10548:SF89. PTHR10548:SF89. 1 hit.

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9BUV0-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSNYVNDMWP GSPQEKDSPS TSRSGGSSRL SSRSRSRSFS RSSRSHSRVS
60 70 80 90 100
SRFSSRSRRS KSRSRSRRRH QRKYRRYSRS YSRSRSRSRS RRYRERRYGF
110 120 130 140 150
TRRYYRSPSR YRSRSRSRSR SRGRSYCGRA YAIARGQRYY GFGRTVYPEE
160 170 180 190 200
HSRWRDRSRT RSRSRTPFRL SEKDRMELLE IAKTNAAKAL GTTNIDLPAS
210 220 230 240 250
LRTVPSAKET SRGIGVSSNG AKPELSEKVT EDGTRNPNEK PTQQRSIAFS
260 270 280 290
SNNSVAKPIQ KSAKAATEEA SSRSPKIDQK KSPYGLWIPI

Note: No experimental confirmation available.

Length:290
Mass (Da):33,613
Last modified:August 21, 2007 - v2
Checksum:iE729EA9895672216
GO
Isoform 2 (identifier: Q9BUV0-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     225-290: LSEKVTEDGT...KSPYGLWIPI → VSILGLSEQNFQKANCQI

Show »
Length:242
Mass (Da):28,364
Checksum:iCCB829DCFDE406A4
GO
Isoform 3 (identifier: Q9BUV0-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     225-226: LS → KS
     227-290: Missing.

Note: No experimental confirmation available. May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.

Show »
Length:226
Mass (Da):26,605
Checksum:iFA6252B925D84FDC
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti147 – 1471Y → H.
Corresponds to variant rs34619962 [ dbSNP | Ensembl ].
VAR_034655
Natural varianti239 – 2391E → G.1 Publication
Corresponds to variant rs1043879 [ dbSNP | Ensembl ].
VAR_034656

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei225 – 29066LSEKV…LWIPI → VSILGLSEQNFQKANCQI in isoform 2. 3 PublicationsVSP_027305Add
BLAST
Alternative sequencei225 – 2262LS → KS in isoform 3. 1 PublicationVSP_027306
Alternative sequencei227 – 29064Missing in isoform 3. 1 PublicationVSP_027307Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK027318 mRNA. Translation: BAB55038.1.
AK292532 mRNA. Translation: BAF85221.1.
AF247168 mRNA. Translation: AAG44543.1.
AF267856 mRNA. Translation: AAG44725.1.
AL031432 Genomic DNA. Translation: CAB37992.1.
CH471134 Genomic DNA. Translation: EAW95157.1.
BC001892 mRNA. Translation: AAH01892.1.
BC041843 mRNA. Translation: AAH41843.1.
BC065040 mRNA. Translation: AAH65040.1.
CCDSiCCDS260.1. [Q9BUV0-1]
RefSeqiNP_064713.3. NM_020317.3. [Q9BUV0-1]
UniGeneiHs.259412.

Genome annotation databases

EnsembliENST00000243189; ENSP00000243189; ENSG00000117616. [Q9BUV0-1]
ENST00000431849; ENSP00000391510; ENSG00000117616. [Q9BUV0-2]
ENST00000473314; ENSP00000457582; ENSG00000117616. [Q9BUV0-3]
GeneIDi57035.
KEGGihsa:57035.
UCSCiuc001bjw.3. human. [Q9BUV0-1]

Polymorphism and mutation databases

BioMutaiC1orf63.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK027318 mRNA. Translation: BAB55038.1.
AK292532 mRNA. Translation: BAF85221.1.
AF247168 mRNA. Translation: AAG44543.1.
AF267856 mRNA. Translation: AAG44725.1.
AL031432 Genomic DNA. Translation: CAB37992.1.
CH471134 Genomic DNA. Translation: EAW95157.1.
BC001892 mRNA. Translation: AAH01892.1.
BC041843 mRNA. Translation: AAH41843.1.
BC065040 mRNA. Translation: AAH65040.1.
CCDSiCCDS260.1. [Q9BUV0-1]
RefSeqiNP_064713.3. NM_020317.3. [Q9BUV0-1]
UniGeneiHs.259412.

3D structure databases

ProteinModelPortaliQ9BUV0.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi121332. 14 interactions.
IntActiQ9BUV0. 7 interactions.
MINTiMINT-1448691.
STRINGi9606.ENSP00000243189.

PTM databases

PhosphoSiteiQ9BUV0.

Polymorphism and mutation databases

BioMutaiC1orf63.
DMDMi156630464.

Proteomic databases

MaxQBiQ9BUV0.
PaxDbiQ9BUV0.
PRIDEiQ9BUV0.

Protocols and materials databases

DNASUi57035.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000243189; ENSP00000243189; ENSG00000117616. [Q9BUV0-1]
ENST00000431849; ENSP00000391510; ENSG00000117616. [Q9BUV0-2]
ENST00000473314; ENSP00000457582; ENSG00000117616. [Q9BUV0-3]
GeneIDi57035.
KEGGihsa:57035.
UCSCiuc001bjw.3. human. [Q9BUV0-1]

Organism-specific databases

CTDi57035.
GeneCardsiGC01M025569.
HGNCiHGNC:25234. RSRP1.
HPAiHPA058992.
neXtProtiNX_Q9BUV0.
PharmGKBiPA142672513.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG40356.
GeneTreeiENSGT00730000111390.
HOGENOMiHOG000111224.
InParanoidiQ9BUV0.
OrthoDBiEOG7WDN50.
PhylomeDBiQ9BUV0.
TreeFamiTF338669.

Miscellaneous databases

GenomeRNAii57035.
NextBioi62785.
PROiQ9BUV0.

Gene expression databases

BgeeiQ9BUV0.
CleanExiHS_C1orf63.
ExpressionAtlasiQ9BUV0. baseline and differential.
GenevestigatoriQ9BUV0.

Family and domain databases

InterProiIPR029656. RSRP1.
[Graphical view]
PANTHERiPTHR10548:SF89. PTHR10548:SF89. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Embryo and Testis.
  2. "A novel gene expressed in the human pituitary gland."
    Song H., Gao G., Peng Y., Ren S., Chen Z., Han Z.
    Submitted (MAR-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Pituitary.
  3. Xu X., Yang Y., Gao G., Xiao H., Chen Z., Han Z.
    Submitted (JAN-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Hypothalamus.
  4. "The DNA sequence and biological annotation of human chromosome 1."
    Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
    , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
    Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 3), VARIANT GLY-239.
    Tissue: Lung, Skin and Testis.

Entry informationi

Entry nameiRSRP1_HUMAN
AccessioniPrimary (citable) accession number: Q9BUV0
Secondary accession number(s): A8K917
, Q49AA4, Q5TH71, Q9GZP6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 21, 2007
Last sequence update: August 21, 2007
Last modified: April 29, 2015
This is version 89 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.