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Protein

Methyltransferase-like protein 22

Gene

METTL22

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Protein N-lysine methyltransferase. In vitro methylates KIN.1 Publication

GO - Molecular functioni

  • heat shock protein binding Source: UniProtKB
  • protein-lysine N-methyltransferase activity Source: Reactome
  • protein methyltransferase activity Source: UniProtKB

GO - Biological processi

  • protein methylation Source: UniProtKB

Keywordsi

Molecular functionMethyltransferase, Transferase
LigandS-adenosyl-L-methionine

Enzyme and pathway databases

ReactomeiR-HSA-8876725 Protein methylation

Names & Taxonomyi

Protein namesi
Recommended name:
Methyltransferase-like protein 22 (EC:2.1.1.-)
Gene namesi
Name:METTL22
Synonyms:C16orf68
ORF Names:LP8272
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 16

Organism-specific databases

EuPathDBiHostDB:ENSG00000067365.14
HGNCiHGNC:28368 METTL22
MIMi615261 gene
neXtProtiNX_Q9BUU2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000067365
PharmGKBiPA144596479

Polymorphism and mutation databases

BioMutaiMETTL22
DMDMi147639349

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002865911 – 404Methyltransferase-like protein 22Add BLAST404

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei132PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ9BUU2
MaxQBiQ9BUU2
PaxDbiQ9BUU2
PeptideAtlasiQ9BUU2
PRIDEiQ9BUU2

PTM databases

iPTMnetiQ9BUU2
PhosphoSitePlusiQ9BUU2

Expressioni

Gene expression databases

BgeeiENSG00000067365
CleanExiHS_C16orf68
ExpressionAtlasiQ9BUU2 baseline and differential
GenevisibleiQ9BUU2 HS

Organism-specific databases

HPAiHPA040803
HPA059882
HPA074173

Interactioni

Subunit structurei

Interacts with members of the heat shock protein 90 and 70 families; these proteins probably are methylation substrates.1 Publication

GO - Molecular functioni

  • heat shock protein binding Source: UniProtKB

Protein-protein interaction databases

BioGridi122539, 19 interactors
IntActiQ9BUU2, 1 interactor
STRINGi9606.ENSP00000371345

Structurei

3D structure databases

ProteinModelPortaliQ9BUU2
SMRiQ9BUU2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiENOG410ISKA Eukaryota
ENOG410Z8JH LUCA
GeneTreeiENSGT00510000048539
HOGENOMiHOG000059652
HOVERGENiHBG055603
InParanoidiQ9BUU2
OMAiHRHLMVR
OrthoDBiEOG091G0JC7
PhylomeDBiQ9BUU2
TreeFamiTF324844

Family and domain databases

InterProiView protein in InterPro
IPR019410 Methyltransf_16
IPR029063 SAM-dependent_MTases
PfamiView protein in Pfam
PF10294 Methyltransf_16, 1 hit
SUPFAMiSSF53335 SSF53335, 1 hit

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9BUU2-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MVQLAPAAAM DEVTFRSDTV LSDVHLYTPN HRHLMVRLNS VGQPVFLSQF
60 70 80 90 100
KLLWSQDSWT DSGAKGGSHR DVHTKEPPSA ETGSTGSPPG SGHGNEGFSL
110 120 130 140 150
QAGTDTTGQE VAEAQLDEDG DLDVVRRPRA ASDSNPAGPL RDKVHPMILA
160 170 180 190 200
QEEDDVLGEE AQGSPHDIIR IEHTMATPLE DVGKQVWRGA LLLADYILFR
210 220 230 240 250
QDLFRGCTAL ELGAGTGLAS IIAATMARTV YCTDVGADLL SMCQRNIALN
260 270 280 290 300
SHLAATGGGI VRVKELDWLK DDLCTDPKVP FSWSQEEISD LYDHTTILFA
310 320 330 340 350
AEVFYDDDLT DAVFKTLSRL AHRLKNACTA ILSVEKRLNF TLRHLDVTCE
360 370 380 390 400
AYDHFRSCLH ALEQLADGKL RFVVEPVEAS FPQLLVYERL QQLELWKIIA

EPVT
Length:404
Mass (Da):44,486
Last modified:May 15, 2007 - v2
Checksum:i049135469B80D6F9
GO
Isoform 2 (identifier: Q9BUU2-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     172-205: EHTMATPLEDVGKQVWRGALLLADYILFRQDLFR → GVAGRPAPGRLHPVPTGPLPRMYSAGARGRHGAR
     206-404: Missing.

Show »
Length:205
Mass (Da):21,813
Checksum:i549514E9F88AA252
GO
Isoform 3 (identifier: Q9BUU2-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-225: Missing.

Show »
Length:179
Mass (Da):20,389
Checksum:i286526061CCA0EEE
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_03213459W → S. Corresponds to variant dbSNP:rs2270286Ensembl.1
Natural variantiVAR_032135219A → T. Corresponds to variant dbSNP:rs2302607Ensembl.1
Natural variantiVAR_059623366A → T1 PublicationCorresponds to variant dbSNP:rs1731000Ensembl.1
Natural variantiVAR_061617375E → K. Corresponds to variant dbSNP:rs55747257Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0251061 – 225Missing in isoform 3. 1 PublicationAdd BLAST225
Alternative sequenceiVSP_025107172 – 205EHTMA…QDLFR → GVAGRPAPGRLHPVPTGPLP RMYSAGARGRHGAR in isoform 2. 2 PublicationsAdd BLAST34
Alternative sequenceiVSP_025108206 – 404Missing in isoform 2. 2 PublicationsAdd BLAST199

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK022495 mRNA Translation: BAB14058.1
AK315383 mRNA Translation: BAG37776.1
AC007224 Genomic DNA No translation available.
AC138420 Genomic DNA No translation available.
AY203956 mRNA Translation: AAP34479.1
CH471112 Genomic DNA Translation: EAW85210.1
CH471112 Genomic DNA Translation: EAW85211.1
BC001908 mRNA Translation: AAH01908.1
CCDSiCCDS10533.2 [Q9BUU2-1]
RefSeqiNP_077014.3, NM_024109.3
UniGeneiHs.306380
Hs.593666

Genome annotation databases

EnsembliENST00000163678; ENSP00000163678; ENSG00000067365 [Q9BUU2-2]
ENST00000381920; ENSP00000371345; ENSG00000067365 [Q9BUU2-1]
GeneIDi79091
KEGGihsa:79091
UCSCiuc002czb.4 human [Q9BUU2-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiMET22_HUMAN
AccessioniPrimary (citable) accession number: Q9BUU2
Secondary accession number(s): B2RD29
, D3DUF2, Q6XYB4, Q9HA03
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 15, 2007
Last sequence update: May 15, 2007
Last modified: April 25, 2018
This is version 106 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health