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Q9BUR4

- WAP53_HUMAN

UniProt

Q9BUR4 - WAP53_HUMAN

Protein

Telomerase Cajal body protein 1

Gene

WRAP53

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 118 (01 Oct 2014)
      Sequence version 1 (01 Jun 2001)
      Previous versions | rss
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    Functioni

    Essential component of the telomerase holoenzyme complex, a ribonucleoprotein complex essential for the replication of chromosome termini that elongates telomeres in most eukaryotes. In the telomerase holoenzyme complex, it controls telomerase localization to Cajal body. Required for delivery of TERC to telomeres during S phase and for telomerase activity. Binds small Cajal body RNAs (scaRNAs). The mRNA encoding this protein plays a critical role in the regulation of p53 expression at the post-transcriptional level; it is involved both in maintaining basal p53 mRNA levels and in p53 induction upon DNA damage.2 Publications

    GO - Molecular functioni

    1. protein binding Source: UniProtKB
    2. RNA binding Source: UniProtKB

    GO - Biological processi

    1. positive regulation of telomerase activity Source: UniProtKB
    2. telomere formation via telomerase Source: UniProtKB

    Keywords - Ligandi

    RNA-binding

    Enzyme and pathway databases

    ReactomeiREACT_7974. Telomere Extension By Telomerase.
    SignaLinkiQ9BUR4.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Telomerase Cajal body protein 1
    Alternative name(s):
    WD repeat-containing protein 79
    WD40 repeat-containing protein encoding RNA antisense to p53
    Gene namesi
    Name:WRAP53
    Synonyms:TCAB1, WDR79
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 17

    Organism-specific databases

    HGNCiHGNC:25522. WRAP53.

    Subcellular locationi

    GO - Cellular componenti

    1. Cajal body Source: UniProtKB
    2. cytoplasm Source: HPA
    3. nucleus Source: HPA
    4. telomerase holoenzyme complex Source: UniProtKB

    Keywords - Cellular componenti

    Cytoplasm, Nucleus

    Pathology & Biotechi

    Involvement in diseasei

    Dyskeratosis congenita, autosomal recessive, 3 (DKCB3) [MIM:613988]: A rare multisystem disorder caused by defective telomere maintenance. It is characterized by progressive bone marrow failure, and the clinical triad of reticulated skin hyperpigmentation, nail dystrophy, and mucosal leukoplakia. Common but variable features include premature graying, aplastic anemia, low platelets, osteoporosis, pulmonary fibrosis, and liver fibrosis among others. Early mortality is often associated with bone marrow failure, infections, fatal pulmonary complications, or malignancy.1 Publication
    Note: The disease is caused by mutations affecting the gene represented in this entry.
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti164 – 1641F → L in DKCB3; disrupts telomerase localization to Cajal bodies resulting in misdirection of telomerase RNA to nucleoli. 1 Publication
    VAR_065873
    Natural varianti376 – 3761H → Y in DKCB3; disrupts telomerase localization to Cajal bodies resulting in misdirection of telomerase RNA to nucleoli. 1 Publication
    VAR_065874
    Natural varianti398 – 3981R → W in DKCB3; disrupts telomerase localization to Cajal bodies resulting in misdirection of telomerase RNA to nucleoli. 1 Publication
    VAR_065875
    Natural varianti435 – 4351G → R in DKCB3; disrupts telomerase localization to Cajal bodies resulting in misdirection of telomerase RNA to nucleoli. 1 Publication
    VAR_065876

    Keywords - Diseasei

    Disease mutation, Dyskeratosis congenita

    Organism-specific databases

    MIMi613988. phenotype.
    Orphaneti1775. Dyskeratosis congenita.
    PharmGKBiPA164727568.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 548548Telomerase Cajal body protein 1PRO_0000242696Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei26 – 261Phosphoserine2 Publications
    Modified residuei30 – 301Phosphoserine2 Publications
    Modified residuei54 – 541Phosphoserine3 Publications
    Modified residuei85 – 851Phosphoserine2 Publications
    Modified residuei90 – 901Phosphoserine4 Publications
    Modified residuei112 – 1121Phosphoserine2 Publications
    Modified residuei114 – 1141Phosphoserine2 Publications
    Modified residuei489 – 4891Phosphothreonine2 Publications
    Modified residuei491 – 4911Phosphoserine4 Publications

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    MaxQBiQ9BUR4.
    PaxDbiQ9BUR4.
    PeptideAtlasiQ9BUR4.
    PRIDEiQ9BUR4.

    PTM databases

    PhosphoSiteiQ9BUR4.

    Expressioni

    Tissue specificityi

    Expressed in all tissues and cell lines examined.1 Publication

    Gene expression databases

    ArrayExpressiQ9BUR4.
    BgeeiQ9BUR4.
    CleanExiHS_WDR79.
    GenevestigatoriQ9BUR4.

    Organism-specific databases

    HPAiHPA023026.
    HPA028130.
    HPA029928.

    Interactioni

    Subunit structurei

    Component of the telomerase holoenzyme complex at least composed of TERT, DKC1, WRAP53/TCAB1, NOP10, NHP2, GAR1, TEP1, EST1A, POT1 and a telomerase RNA template component (TERC).1 Publication

    Protein-protein interaction databases

    BioGridi120440. 10 interactions.
    DIPiDIP-56796N.
    IntActiQ9BUR4. 3 interactions.
    STRINGi9606.ENSP00000324203.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9BUR4.
    SMRiQ9BUR4. Positions 137-483.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Repeati167 – 20640WD 1Add
    BLAST
    Repeati222 – 26746WD 2Add
    BLAST
    Repeati272 – 31342WD 3Add
    BLAST
    Repeati323 – 36442WD 4Add
    BLAST
    Repeati365 – 40541WD 5Add
    BLAST
    Repeati411 – 45040WD 6Add
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi8 – 5750Pro-richAdd
    BLAST

    Sequence similaritiesi

    Contains 6 WD repeats.PROSITE-ProRule annotation

    Keywords - Domaini

    Repeat, WD repeat

    Phylogenomic databases

    eggNOGiCOG2319.
    HOGENOMiHOG000030352.
    HOVERGENiHBG098609.
    InParanoidiQ9BUR4.
    OMAiEYAEMVP.
    OrthoDBiEOG7FNC74.
    PhylomeDBiQ9BUR4.
    TreeFamiTF315169.

    Family and domain databases

    Gene3Di2.130.10.10. 2 hits.
    InterProiIPR015943. WD40/YVTN_repeat-like_dom.
    IPR001680. WD40_repeat.
    IPR017986. WD40_repeat_dom.
    [Graphical view]
    PfamiPF00400. WD40. 4 hits.
    [Graphical view]
    SMARTiSM00320. WD40. 5 hits.
    [Graphical view]
    SUPFAMiSSF50978. SSF50978. 1 hit.
    PROSITEiPS50082. WD_REPEATS_2. 2 hits.
    PS50294. WD_REPEATS_REGION. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9BUR4-1 [UniParc]FASTAAdd to Basket

    « Hide

    MKTLETQPLA PDCCPSDQDP APAHPSPHAS PMNKNADSEL MPPPPERGDP    50
    PRLSPDPVAG SAVSQELREG DPVSLSTPLE TEFGSPSELS PRIEEQELSE 100
    NTSLPAEEAN GSLSEEEANG PELGSGKAME DTSGEPAAED EGDTAWNYSF 150
    SQLPRFLSGS WSEFSTQPEN FLKGCKWAPD GSCILTNSAD NILRIYNLPP 200
    ELYHEGEQVE YAEMVPVLRM VEGDTIYDYC WYSLMSSAQP DTSYVASSSR 250
    ENPIHIWDAF TGELRASFRA YNHLDELTAA HSLCFSPDGS QLFCGFNRTV 300
    RVFSTARPGR DCEVRATFAK KQGQSGIISC IAFSPAQPLY ACGSYGRSLG 350
    LYAWDDGSPL ALLGGHQGGI THLCFHPDGN RFFSGARKDA ELLCWDLRQS 400
    GYPLWSLGRE VTTNQRIYFD LDPTGQFLVS GSTSGAVSVW DTDGPGNDGK 450
    PEPVLSFLPQ KDCTNGVSLH PSLPLLATAS GQRVFPEPTE SGDEGEELGL 500
    PLLSTRHVHL ECRLQLWWCG GAPDSSIPDD HQGEKGQGGT EGGVGELI 548
    Length:548
    Mass (Da):59,309
    Last modified:June 1, 2001 - v1
    Checksum:i4687517268A813B5
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti21 – 211A → V in BAA91579. (PubMed:14702039)Curated
    Sequence conflicti497 – 4971E → G in BAG51781. (PubMed:14702039)Curated
    Sequence conflicti526 – 5261S → G in BAG51781. (PubMed:14702039)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti11 – 111P → S.
    Corresponds to variant rs17880282 [ dbSNP | Ensembl ].
    VAR_026865
    Natural varianti68 – 681R → G.2 Publications
    Corresponds to variant rs2287499 [ dbSNP | Ensembl ].
    VAR_026866
    Natural varianti136 – 1361P → R.
    Corresponds to variant rs34067256 [ dbSNP | Ensembl ].
    VAR_057618
    Natural varianti164 – 1641F → L in DKCB3; disrupts telomerase localization to Cajal bodies resulting in misdirection of telomerase RNA to nucleoli. 1 Publication
    VAR_065873
    Natural varianti187 – 1871N → T.
    Corresponds to variant rs35762939 [ dbSNP | Ensembl ].
    VAR_057619
    Natural varianti376 – 3761H → Y in DKCB3; disrupts telomerase localization to Cajal bodies resulting in misdirection of telomerase RNA to nucleoli. 1 Publication
    VAR_065874
    Natural varianti398 – 3981R → W in DKCB3; disrupts telomerase localization to Cajal bodies resulting in misdirection of telomerase RNA to nucleoli. 1 Publication
    VAR_065875
    Natural varianti435 – 4351G → R in DKCB3; disrupts telomerase localization to Cajal bodies resulting in misdirection of telomerase RNA to nucleoli. 1 Publication
    VAR_065876
    Natural varianti494 – 4941E → Q.
    Corresponds to variant rs35123152 [ dbSNP | Ensembl ].
    VAR_057620
    Natural varianti522 – 5221A → G.1 Publication
    Corresponds to variant rs7640 [ dbSNP | Ensembl ].
    VAR_026867

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY766322 mRNA. Translation: AAW92115.1.
    DQ431240 mRNA. Translation: ABD92817.1.
    DQ431241 mRNA. Translation: ABD92818.1.
    AK001247 mRNA. Translation: BAA91579.1.
    AK056669 mRNA. Translation: BAG51781.1.
    CH471108 Genomic DNA. Translation: EAW90136.1.
    CH471108 Genomic DNA. Translation: EAW90138.1.
    CH471108 Genomic DNA. Translation: EAW90139.1.
    BC002336 mRNA. Translation: AAH02336.1.
    CCDSiCCDS11119.1.
    RefSeqiNP_001137462.1. NM_001143990.1.
    NP_001137463.1. NM_001143991.1.
    NP_001137464.1. NM_001143992.1.
    NP_060551.2. NM_018081.2.
    UniGeneiHs.408312.

    Genome annotation databases

    EnsembliENST00000316024; ENSP00000324203; ENSG00000141499.
    ENST00000396463; ENSP00000379727; ENSG00000141499.
    ENST00000431639; ENSP00000397219; ENSG00000141499.
    ENST00000457584; ENSP00000411061; ENSG00000141499.
    GeneIDi55135.
    KEGGihsa:55135.
    UCSCiuc002gip.3. human.

    Polymorphism databases

    DMDMi74761275.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Web resourcesi

    Atlas of Genetics and Cytogenetics in Oncology and Haematology

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY766322 mRNA. Translation: AAW92115.1 .
    DQ431240 mRNA. Translation: ABD92817.1 .
    DQ431241 mRNA. Translation: ABD92818.1 .
    AK001247 mRNA. Translation: BAA91579.1 .
    AK056669 mRNA. Translation: BAG51781.1 .
    CH471108 Genomic DNA. Translation: EAW90136.1 .
    CH471108 Genomic DNA. Translation: EAW90138.1 .
    CH471108 Genomic DNA. Translation: EAW90139.1 .
    BC002336 mRNA. Translation: AAH02336.1 .
    CCDSi CCDS11119.1.
    RefSeqi NP_001137462.1. NM_001143990.1.
    NP_001137463.1. NM_001143991.1.
    NP_001137464.1. NM_001143992.1.
    NP_060551.2. NM_018081.2.
    UniGenei Hs.408312.

    3D structure databases

    ProteinModelPortali Q9BUR4.
    SMRi Q9BUR4. Positions 137-483.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 120440. 10 interactions.
    DIPi DIP-56796N.
    IntActi Q9BUR4. 3 interactions.
    STRINGi 9606.ENSP00000324203.

    PTM databases

    PhosphoSitei Q9BUR4.

    Polymorphism databases

    DMDMi 74761275.

    Proteomic databases

    MaxQBi Q9BUR4.
    PaxDbi Q9BUR4.
    PeptideAtlasi Q9BUR4.
    PRIDEi Q9BUR4.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000316024 ; ENSP00000324203 ; ENSG00000141499 .
    ENST00000396463 ; ENSP00000379727 ; ENSG00000141499 .
    ENST00000431639 ; ENSP00000397219 ; ENSG00000141499 .
    ENST00000457584 ; ENSP00000411061 ; ENSG00000141499 .
    GeneIDi 55135.
    KEGGi hsa:55135.
    UCSCi uc002gip.3. human.

    Organism-specific databases

    CTDi 55135.
    GeneCardsi GC17P007589.
    GeneReviewsi WRAP53.
    HGNCi HGNC:25522. WRAP53.
    HPAi HPA023026.
    HPA028130.
    HPA029928.
    MIMi 612661. gene.
    613988. phenotype.
    neXtProti NX_Q9BUR4.
    Orphaneti 1775. Dyskeratosis congenita.
    PharmGKBi PA164727568.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG2319.
    HOGENOMi HOG000030352.
    HOVERGENi HBG098609.
    InParanoidi Q9BUR4.
    OMAi EYAEMVP.
    OrthoDBi EOG7FNC74.
    PhylomeDBi Q9BUR4.
    TreeFami TF315169.

    Enzyme and pathway databases

    Reactomei REACT_7974. Telomere Extension By Telomerase.
    SignaLinki Q9BUR4.

    Miscellaneous databases

    GenomeRNAii 55135.
    NextBioi 58818.
    PROi Q9BUR4.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q9BUR4.
    Bgeei Q9BUR4.
    CleanExi HS_WDR79.
    Genevestigatori Q9BUR4.

    Family and domain databases

    Gene3Di 2.130.10.10. 2 hits.
    InterProi IPR015943. WD40/YVTN_repeat-like_dom.
    IPR001680. WD40_repeat.
    IPR017986. WD40_repeat_dom.
    [Graphical view ]
    Pfami PF00400. WD40. 4 hits.
    [Graphical view ]
    SMARTi SM00320. WD40. 5 hits.
    [Graphical view ]
    SUPFAMi SSF50978. SSF50978. 1 hit.
    PROSITEi PS50082. WD_REPEATS_2. 2 hits.
    PS50294. WD_REPEATS_REGION. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Endogenous p53 antisense transcript Wrap53 is required for p53 stabilization upon DNA damage."
      Hammarsund M.
      Submitted (MAR-2006) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Brain.
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANT GLY-68.
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Kidney.
    5. "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."
      Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M.
      Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-54, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    6. "A probability-based approach for high-throughput protein phosphorylation analysis and site localization."
      Beausoleil S.A., Villen J., Gerber S.A., Rush J., Gygi S.P.
      Nat. Biotechnol. 24:1285-1292(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-90, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    7. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Embryonic kidney.
    8. "Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis."
      Cantin G.T., Yi W., Lu B., Park S.K., Xu T., Lee J.-D., Yates J.R. III
      J. Proteome Res. 7:1346-1351(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-54, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    9. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-26; SER-30; SER-54; SER-85; SER-90; SER-112; SER-114; THR-489 AND SER-491, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    10. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
      Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
      Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    11. "Wrap53, a natural p53 antisense transcript required for p53 induction upon DNA damage."
      Mahmoudi S., Henriksson S., Corcoran M., Mendez-Vidal C., Wiman K.G., Farnebo M.
      Mol. Cell 33:462-471(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, ALTERNATIVE SPLICING.
    12. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
      Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
      Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-85; SER-90; SER-112; SER-114; THR-489 AND SER-491, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Leukemic T-cell.
    13. "A human telomerase holoenzyme protein required for Cajal body localization and telomere synthesis."
      Venteicher A.S., Abreu E.B., Meng Z., McCann K.E., Terns R.M., Veenstra T.D., Terns M.P., Artandi S.E.
      Science 323:644-648(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, SUBCELLULAR LOCATION, IDENTIFICATION BY MASS SPECTROMETRY, IDENTIFICATION IN THE TELOMERASE HOLOENZYME COMPLEX, RNA-BINDING.
    14. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
      Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
      Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-26; SER-30; SER-90 AND SER-491, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    15. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
      Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
      Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-491, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    16. "Disruption of telomerase trafficking by TCAB1 mutation causes dyskeratosis congenita."
      Zhong F., Savage S.A., Shkreli M., Giri N., Jessop L., Myers T., Chen R., Alter B.P., Artandi S.E.
      Genes Dev. 25:11-16(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: VARIANTS DKCB3 LEU-164; TYR-376; TRP-398 AND ARG-435, VARIANTS GLY-68 AND GLY-522, CHARACTERIZATION OF VARIANTS DKCB3 LEU-164; TYR-376; TRP-398 AND ARG-435.

    Entry informationi

    Entry nameiWAP53_HUMAN
    AccessioniPrimary (citable) accession number: Q9BUR4
    Secondary accession number(s): B3KPR9
    , D3DTQ4, Q08ET9, Q9NW09
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 27, 2006
    Last sequence update: June 1, 2001
    Last modified: October 1, 2014
    This is version 118 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 17
      Human chromosome 17: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3