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Q9BUQ8

- DDX23_HUMAN

UniProt

Q9BUQ8 - DDX23_HUMAN

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Protein

Probable ATP-dependent RNA helicase DDX23

Gene

DDX23

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Involved in pre-mRNA splicing and its phosphorylated form (by SRPK2) is required for spliceosomal B complex formation.1 Publication

Catalytic activityi

ATP + H2O = ADP + phosphate.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi435 – 4428ATPPROSITE-ProRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. ATP-dependent RNA helicase activity Source: ProtInc
  3. poly(A) RNA binding Source: UniProtKB

GO - Biological processi

  1. ATP catabolic process Source: GOC
  2. cis assembly of pre-catalytic spliceosome Source: HGNC
  3. gene expression Source: Reactome
  4. mRNA splicing, via spliceosome Source: UniProtKB
  5. RNA splicing Source: Reactome
  6. RNA splicing, via transesterification reactions Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Helicase, Hydrolase

Keywords - Biological processi

mRNA processing, mRNA splicing

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiREACT_1753. mRNA Splicing - Minor Pathway.
REACT_467. mRNA Splicing - Major Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable ATP-dependent RNA helicase DDX23 (EC:3.6.4.13)
Alternative name(s):
100 kDa U5 snRNP-specific protein
DEAD box protein 23
PRP28 homolog
U5-100kD
Gene namesi
Name:DDX23
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 12

Organism-specific databases

HGNCiHGNC:17347. DDX23.

Subcellular locationi

Nucleus 2 Publications

GO - Cellular componenti

  1. catalytic step 2 spliceosome Source: UniProtKB
  2. extracellular vesicular exosome Source: UniProt
  3. mitochondrion Source: HPA
  4. nucleoplasm Source: Reactome
  5. nucleus Source: HPA
  6. plasma membrane Source: HPA
  7. U5 snRNP Source: HGNC
Complete GO annotation...

Keywords - Cellular componenti

Nucleus, Spliceosome

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134934941.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 820820Probable ATP-dependent RNA helicase DDX23PRO_0000055128Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei14 – 141Phosphoserine2 Publications
Modified residuei16 – 161Phosphoserine1 Publication
Modified residuei107 – 1071Phosphoserine1 Publication
Modified residuei109 – 1091Phosphoserine1 Publication

Post-translational modificationi

In vitro phosphorylated by CLK1 and U1 snRNP-associated protein kinase. Phosphorylated by SRPK2 and this phosphorylation is required for its association with the tri-snRNP (U4/U6-U5 tri-small nuclear ribonucleoproteins) and subsequent spliceosomal B complex formation.4 Publications

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ9BUQ8.
PaxDbiQ9BUQ8.
PRIDEiQ9BUQ8.

PTM databases

PhosphoSiteiQ9BUQ8.

Expressioni

Gene expression databases

BgeeiQ9BUQ8.
CleanExiHS_DDX23.
ExpressionAtlasiQ9BUQ8. baseline and differential.
GenevestigatoriQ9BUQ8.

Organism-specific databases

HPAiHPA038680.

Interactioni

Subunit structurei

The phosphorylated form (by SRPK2) is a component of the U4/U6-U5 tri-snRNP complex composed of the U4, U6 and U5 snRNAs and at least PRPF3, PRPF4, PRPF6, PRPF8, PRPF31, SNRNP200, TXNL4A, WDR57, SNRNP40, DDX23, CD2BP2, PPIH, NHP2L1, EFTUD2, SART1 and USP39. Identified in the spliceosome C complex. Interacts with ERBB4.4 Publications

Protein-protein interaction databases

BioGridi114811. 54 interactions.
DIPiDIP-34974N.
IntActiQ9BUQ8. 10 interactions.
MINTiMINT-1572793.
STRINGi9606.ENSP00000310723.

Structurei

Secondary structure

1
820
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi357 – 3593Combined sources
Helixi362 – 3643Combined sources
Helixi367 – 37711Combined sources
Beta strandi379 – 3857Combined sources
Turni393 – 3953Combined sources
Helixi400 – 40910Combined sources
Helixi416 – 42510Combined sources
Turni426 – 4283Combined sources
Beta strandi431 – 4344Combined sources
Helixi441 – 45515Combined sources
Helixi458 – 4614Combined sources
Beta strandi470 – 4745Combined sources
Helixi478 – 49215Combined sources
Helixi493 – 4953Combined sources
Beta strandi499 – 5024Combined sources
Beta strandi504 – 5063Combined sources
Helixi508 – 5169Combined sources
Beta strandi520 – 5245Combined sources
Helixi526 – 5349Combined sources
Beta strandi545 – 5506Combined sources
Helixi551 – 5566Combined sources
Helixi560 – 5678Combined sources
Helixi572 – 5743Combined sources
Helixi580 – 5834Combined sources
Helixi585 – 5939Combined sources
Helixi595 – 5973Combined sources
Beta strandi601 – 6077Combined sources
Helixi611 – 62010Combined sources
Beta strandi625 – 6295Combined sources
Helixi635 – 6384Combined sources
Beta strandi639 – 6457Combined sources
Helixi648 – 6503Combined sources
Helixi651 – 66010Combined sources
Beta strandi667 – 6704Combined sources
Helixi674 – 68613Combined sources
Beta strandi691 – 6933Combined sources
Helixi704 – 7129Combined sources
Beta strandi717 – 7204Combined sources
Beta strandi734 – 7407Combined sources
Helixi745 – 7528Combined sources
Helixi753 – 7553Combined sources
Beta strandi757 – 7604Combined sources
Beta strandi763 – 7686Combined sources
Helixi770 – 7756Combined sources
Helixi776 – 7849Combined sources
Helixi793 – 7964Combined sources
Helixi799 – 8013Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4NHOX-ray2.00A338-820[»]
ProteinModelPortaliQ9BUQ8.
SMRiQ9BUQ8. Positions 352-806.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini422 – 627206Helicase ATP-bindingPROSITE-ProRule annotationAdd
BLAST
Domaini651 – 799149Helicase C-terminalPROSITE-ProRule annotationAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi391 – 41929Q motifAdd
BLAST
Motifi549 – 5524DEAD box

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi20 – 122103Arg-richAdd
BLAST
Compositional biasi128 – 240113Glu-richAdd
BLAST

Sequence similaritiesi

Contains 1 helicase ATP-binding domain.PROSITE-ProRule annotation
Contains 1 helicase C-terminal domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiCOG0513.
GeneTreeiENSGT00770000120586.
HOGENOMiHOG000268796.
HOVERGENiHBG102054.
InParanoidiQ9BUQ8.
KOiK12858.
OMAiPIRNWKE.
OrthoDBiEOG7XH6P9.
PhylomeDBiQ9BUQ8.
TreeFamiTF300527.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
InterProiIPR011545. DEAD/DEAH_box_helicase_dom.
IPR014001. Helicase_ATP-bd.
IPR001650. Helicase_C.
IPR027417. P-loop_NTPase.
IPR000629. RNA-helicase_DEAD-box_CS.
IPR014014. RNA_helicase_DEAD_Q_motif.
[Graphical view]
PfamiPF00270. DEAD. 1 hit.
PF00271. Helicase_C. 1 hit.
[Graphical view]
SMARTiSM00487. DEXDc. 1 hit.
SM00490. HELICc. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 2 hits.
PROSITEiPS00039. DEAD_ATP_HELICASE. 1 hit.
PS51192. HELICASE_ATP_BIND_1. 1 hit.
PS51194. HELICASE_CTER. 1 hit.
PS51195. Q_MOTIF. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q9BUQ8-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAGELADKKD RDASPSKEER KRSRTPDRER DRDRDRKSSP SKDRKRHRSR
60 70 80 90 100
DRRRGGSRSR SRSRSKSAER ERRHKERERD KERDRNKKDR DRDKDGHRRD
110 120 130 140 150
KDRKRSSLSP GRGKDFKSRK DRDSKKDEED EHGDKKPKAQ PLSLEELLAK
160 170 180 190 200
KKAEEEAEAK PKFLSKAERE AEALKRRQQE VEERQRMLEE ERKKRKQFQD
210 220 230 240 250
LGRKMLEDPQ ERERRERRER MERETNGNED EEGRQKIREE KDKSKELHAI
260 270 280 290 300
KERYLGGIKK RRRTRHLNDR KFVFEWDASE DTSIDYNPLY KERHQVQLLG
310 320 330 340 350
RGFIAGIDLK QQKREQSRFY GDLMEKRRTL EEKEQEEARL RKLRKKEAKQ
360 370 380 390 400
RWDDRHWSQK KLDEMTDRDW RIFREDYSIT TKGGKIPNPI RSWKDSSLPP
410 420 430 440 450
HILEVIDKCG YKEPTPIQRQ AIPIGLQNRD IIGVAETGSG KTAAFLIPLL
460 470 480 490 500
VWITTLPKID RIEESDQGPY AIILAPTREL AQQIEEETIK FGKPLGIRTV
510 520 530 540 550
AVIGGISRED QGFRLRMGCE IVIATPGRLI DVLENRYLVL SRCTYVVLDE
560 570 580 590 600
ADRMIDMGFE PDVQKILEHM PVSNQKPDTD EAEDPEKMLA NFESGKHKYR
610 620 630 640 650
QTVMFTATMP PAVERLARSY LRRPAVVYIG SAGKPHERVE QKVFLMSESE
660 670 680 690 700
KRKKLLAILE QGFDPPIIIF VNQKKGCDVL AKSLEKMGYN ACTLHGGKGQ
710 720 730 740 750
EQREFALSNL KAGAKDILVA TDVAGRGIDI QDVSMVVNYD MAKNIEDYIH
760 770 780 790 800
RIGRTGRAGK SGVAITFLTK EDSAVFYELK QAILESPVSS CPPELANHPD
810 820
AQHKPGTILT KKRREETIFA
Length:820
Mass (Da):95,583
Last modified:October 23, 2007 - v3
Checksum:i01DD5BCF8BFBA2DB
GO
Isoform 2 (identifier: Q9BUQ8-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     107-108: SL → RH
     109-820: Missing.

Note: No experimental confirmation available.

Show »
Length:108
Mass (Da):13,401
Checksum:iE188544D668BD767
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti137 – 1371P → L in AAB87902. (PubMed:9409622)Curated
Sequence conflicti281 – 2811D → E in AAB87902. (PubMed:9409622)Curated
Sequence conflicti309 – 3091L → F in AAB87902. (PubMed:9409622)Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei107 – 1082SL → RH in isoform 2. 1 PublicationVSP_056575
Alternative sequencei109 – 820712Missing in isoform 2. 1 PublicationVSP_056576Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF026402 mRNA. Translation: AAB87902.1.
AK294877 mRNA. Translation: BAG57976.1.
AK312379 mRNA. Translation: BAG35297.1.
AC117498 Genomic DNA. No translation available.
CH471111 Genomic DNA. Translation: EAW58011.1.
BC002366 mRNA. Translation: AAH02366.1.
CCDSiCCDS8770.1. [Q9BUQ8-1]
RefSeqiNP_004809.2. NM_004818.2. [Q9BUQ8-1]
UniGeneiHs.130098.

Genome annotation databases

EnsembliENST00000308025; ENSP00000310723; ENSG00000174243. [Q9BUQ8-1]
ENST00000547135; ENSP00000446770; ENSG00000174243. [Q9BUQ8-2]
GeneIDi9416.
KEGGihsa:9416.
UCSCiuc001rsm.3. human. [Q9BUQ8-1]

Polymorphism databases

DMDMi160385708.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF026402 mRNA. Translation: AAB87902.1 .
AK294877 mRNA. Translation: BAG57976.1 .
AK312379 mRNA. Translation: BAG35297.1 .
AC117498 Genomic DNA. No translation available.
CH471111 Genomic DNA. Translation: EAW58011.1 .
BC002366 mRNA. Translation: AAH02366.1 .
CCDSi CCDS8770.1. [Q9BUQ8-1 ]
RefSeqi NP_004809.2. NM_004818.2. [Q9BUQ8-1 ]
UniGenei Hs.130098.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
4NHO X-ray 2.00 A 338-820 [» ]
ProteinModelPortali Q9BUQ8.
SMRi Q9BUQ8. Positions 352-806.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 114811. 54 interactions.
DIPi DIP-34974N.
IntActi Q9BUQ8. 10 interactions.
MINTi MINT-1572793.
STRINGi 9606.ENSP00000310723.

PTM databases

PhosphoSitei Q9BUQ8.

Polymorphism databases

DMDMi 160385708.

Proteomic databases

MaxQBi Q9BUQ8.
PaxDbi Q9BUQ8.
PRIDEi Q9BUQ8.

Protocols and materials databases

DNASUi 9416.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000308025 ; ENSP00000310723 ; ENSG00000174243 . [Q9BUQ8-1 ]
ENST00000547135 ; ENSP00000446770 ; ENSG00000174243 . [Q9BUQ8-2 ]
GeneIDi 9416.
KEGGi hsa:9416.
UCSCi uc001rsm.3. human. [Q9BUQ8-1 ]

Organism-specific databases

CTDi 9416.
GeneCardsi GC12M049223.
HGNCi HGNC:17347. DDX23.
HPAi HPA038680.
MIMi 612172. gene.
neXtProti NX_Q9BUQ8.
PharmGKBi PA134934941.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG0513.
GeneTreei ENSGT00770000120586.
HOGENOMi HOG000268796.
HOVERGENi HBG102054.
InParanoidi Q9BUQ8.
KOi K12858.
OMAi PIRNWKE.
OrthoDBi EOG7XH6P9.
PhylomeDBi Q9BUQ8.
TreeFami TF300527.

Enzyme and pathway databases

Reactomei REACT_1753. mRNA Splicing - Minor Pathway.
REACT_467. mRNA Splicing - Major Pathway.

Miscellaneous databases

ChiTaRSi DDX23. human.
GeneWikii DDX23.
GenomeRNAii 9416.
NextBioi 35278.
PROi Q9BUQ8.
SOURCEi Search...

Gene expression databases

Bgeei Q9BUQ8.
CleanExi HS_DDX23.
ExpressionAtlasi Q9BUQ8. baseline and differential.
Genevestigatori Q9BUQ8.

Family and domain databases

Gene3Di 3.40.50.300. 2 hits.
InterProi IPR011545. DEAD/DEAH_box_helicase_dom.
IPR014001. Helicase_ATP-bd.
IPR001650. Helicase_C.
IPR027417. P-loop_NTPase.
IPR000629. RNA-helicase_DEAD-box_CS.
IPR014014. RNA_helicase_DEAD_Q_motif.
[Graphical view ]
Pfami PF00270. DEAD. 1 hit.
PF00271. Helicase_C. 1 hit.
[Graphical view ]
SMARTi SM00487. DEXDc. 1 hit.
SM00490. HELICc. 1 hit.
[Graphical view ]
SUPFAMi SSF52540. SSF52540. 2 hits.
PROSITEi PS00039. DEAD_ATP_HELICASE. 1 hit.
PS51192. HELICASE_ATP_BIND_1. 1 hit.
PS51194. HELICASE_CTER. 1 hit.
PS51195. Q_MOTIF. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The human U5 snRNP-specific 100-kD protein is an RS domain-containing, putative RNA helicase with significant homology to the yeast splicing factor Prp28p."
    Teigelkamp S., Mundt C., Achsel T., Will C.L., Luehrmann R.
    RNA 3:1313-1326(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), PROTEIN SEQUENCE OF 272-290; 409-419 AND 433-441, SUBCELLULAR LOCATION, PHOSPHORYLATION, IDENTIFICATION IN U5 AND U5/4/6 SNRNP COMPLEXES.
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
    Tissue: Amygdala and Brain.
  3. "The finished DNA sequence of human chromosome 12."
    Scherer S.E., Muzny D.M., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J., Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R.
    , Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Montgomery K.T., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Lovering R.C., Wheeler D.A., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clerc-Blankenburg K.P., Davis C., Delgado O., Dinh H.H., Draper H., Gonzalez-Garay M.L., Havlak P., Jackson L.R., Jacob L.S., Kelly S.H., Li L., Li Z., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Pasternak S., Perez L.M., Plopper F.J.H., Santibanez J., Shen H., Tabor P.E., Verduzco D., Waldron L., Wang Q., Williams G.A., Zhang J., Zhou J., Allen C.C., Amin A.G., Anyalebechi V., Bailey M., Barbaria J.A., Bimage K.E., Bryant N.P., Burch P.E., Burkett C.E., Burrell K.L., Calderon E., Cardenas V., Carter K., Casias K., Cavazos I., Cavazos S.R., Ceasar H., Chacko J., Chan S.N., Chavez D., Christopoulos C., Chu J., Cockrell R., Cox C.D., Dang M., Dathorne S.R., David R., Davis C.M., Davy-Carroll L., Deshazo D.R., Donlin J.E., D'Souza L., Eaves K.A., Egan A., Emery-Cohen A.J., Escotto M., Flagg N., Forbes L.D., Gabisi A.M., Garza M., Hamilton C., Henderson N., Hernandez O., Hines S., Hogues M.E., Huang M., Idlebird D.G., Johnson R., Jolivet A., Jones S., Kagan R., King L.M., Leal B., Lebow H., Lee S., LeVan J.M., Lewis L.C., London P., Lorensuhewa L.M., Loulseged H., Lovett D.A., Lucier A., Lucier R.L., Ma J., Madu R.C., Mapua P., Martindale A.D., Martinez E., Massey E., Mawhiney S., Meador M.G., Mendez S., Mercado C., Mercado I.C., Merritt C.E., Miner Z.L., Minja E., Mitchell T., Mohabbat F., Mohabbat K., Montgomery B., Moore N., Morris S., Munidasa M., Ngo R.N., Nguyen N.B., Nickerson E., Nwaokelemeh O.O., Nwokenkwo S., Obregon M., Oguh M., Oragunye N., Oviedo R.J., Parish B.J., Parker D.N., Parrish J., Parks K.L., Paul H.A., Payton B.A., Perez A., Perrin W., Pickens A., Primus E.L., Pu L.-L., Puazo M., Quiles M.M., Quiroz J.B., Rabata D., Reeves K., Ruiz S.J., Shao H., Sisson I., Sonaike T., Sorelle R.P., Sutton A.E., Svatek A.F., Svetz L.A., Tamerisa K.S., Taylor T.R., Teague B., Thomas N., Thorn R.D., Trejos Z.Y., Trevino B.K., Ukegbu O.N., Urban J.B., Vasquez L.I., Vera V.A., Villasana D.M., Wang L., Ward-Moore S., Warren J.T., Wei X., White F., Williamson A.L., Wleczyk R., Wooden H.S., Wooden S.H., Yen J., Yoon L., Yoon V., Zorrilla S.E., Nelson D., Kucherlapati R., Weinstock G., Gibbs R.A.
    Nature 440:346-351(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Lung.
  6. "Purification and characterization of native spliceosomes suitable for three-dimensional structural analysis."
    Jurica M.S., Licklider L.J., Gygi S.P., Grigorieff N., Moore M.J.
    RNA 8:426-439(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY, IDENTIFICATION IN THE SPLICEOSOMAL C COMPLEX.
  7. "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."
    Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M.
    Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  8. "The network of protein-protein interactions within the human U4/U6.U5 tri-snRNP."
    Liu S., Rauhut R., Vornlocher H.-P., Luehrmann R.
    RNA 12:1418-1430(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBUNIT.
  9. "Phosphorylation of human PRP28 by SRPK2 is required for integration of the U4/U6-U5 tri-snRNP into the spliceosome."
    Mathew R., Hartmuth K., Moehlmann S., Urlaub H., Ficner R., Luehrmann R.
    Nat. Struct. Mol. Biol. 15:435-443(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, PHOSPHORYLATION BY SRPK2.
  10. "Interactions of ErbB4 and Kap1 connect the growth factor and DNA damage response pathways."
    Gilmore-Hebert M., Ramabhadran R., Stern D.F.
    Mol. Cancer Res. 8:1388-1398(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY, INTERACTION WITH ERBB4, SUBCELLULAR LOCATION.
  11. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
    Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
    Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-14 AND SER-16, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  12. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  13. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
    Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
    Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-14; SER-107 AND SER-109, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  14. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiDDX23_HUMAN
AccessioniPrimary (citable) accession number: Q9BUQ8
Secondary accession number(s): B2R600, B4DH15, O43188
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 7, 2005
Last sequence update: October 23, 2007
Last modified: November 26, 2014
This is version 129 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3