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Q9BUP3

- HTAI2_HUMAN

UniProt

Q9BUP3 - HTAI2_HUMAN

Protein

Oxidoreductase HTATIP2

Gene

HTATIP2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 112 (01 Oct 2014)
      Sequence version 2 (11 Jan 2011)
      Previous versions | rss
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    Functioni

    Oxidoreductase required for tumor suppression. NAPDH-bound form inhibits nuclear import by competing with nuclear import substrates for binding to a subset of nuclear transport receptors. May act as a redox sensor linked to transcription through regulation of nuclear import. Isoform 1 is a metastasis suppressor with proapoptotic as well as antiangiogenic properties. Isoform 2 has an antiapoptotic effect.4 Publications

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei131 – 1311Substrate1 Publication
    Active sitei143 – 1431Proton acceptor1 Publication
    Active sitei147 – 14711 Publication

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi19 – 5234NADP1 PublicationAdd
    BLAST

    GO - Molecular functioni

    1. oxidoreductase activity Source: UniProtKB-KW
    2. protein binding Source: UniProtKB
    3. transcription coactivator activity Source: ProtInc

    GO - Biological processi

    1. angiogenesis Source: UniProtKB-KW
    2. apoptotic process Source: UniProtKB-KW
    3. cell differentiation Source: UniProtKB-KW
    4. negative regulation of apoptotic process Source: UniProtKB
    5. nuclear import Source: UniProtKB
    6. regulation of angiogenesis Source: UniProtKB
    7. regulation of transcription from RNA polymerase II promoter Source: ProtInc
    8. viral process Source: UniProtKB-KW

    Keywords - Molecular functioni

    Developmental protein, Oxidoreductase

    Keywords - Biological processi

    Angiogenesis, Apoptosis, Differentiation, Host-virus interaction

    Keywords - Ligandi

    NADP

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Oxidoreductase HTATIP2 (EC:1.1.1.-)
    Alternative name(s):
    30 kDa HIV-1 TAT-interacting protein
    HIV-1 TAT-interactive protein 2
    Gene namesi
    Name:HTATIP2Imported
    Synonyms:CC3Imported, TIP301 Publication
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 11

    Organism-specific databases

    HGNCiHGNC:16637. HTATIP2.

    Subcellular locationi

    Cytoplasm 1 Publication. Nucleus envelope 1 Publication

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB
    2. membrane Source: UniProtKB
    3. nuclear envelope Source: UniProtKB
    4. nucleus Source: ProtInc

    Keywords - Cellular componenti

    Cytoplasm, Nucleus

    Pathology & Biotechi

    Mutagenesis

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Mutagenesisi28 – 314GETG → VETA: Loss of proapoptotic and metastatis-inhibiting effect. 1 Publication
    Mutagenesisi106 – 1061R → H: Loss of association with nucleus. 2 Publications

    Keywords - Diseasei

    Tumor suppressor

    Organism-specific databases

    PharmGKBiPA29539.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11Removed1 Publication
    Chaini2 – 242241Oxidoreductase HTATIP2PRO_0000072544Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei2 – 21N-acetylalanine1 Publication

    Keywords - PTMi

    Acetylation

    Proteomic databases

    MaxQBiQ9BUP3.
    PaxDbiQ9BUP3.
    PRIDEiQ9BUP3.

    PTM databases

    PhosphoSiteiQ9BUP3.

    Expressioni

    Tissue specificityi

    Ubiquitous. Highest level in liver. High levels in lung, skeletal muscle, pancreas and placenta. Moderate levels in heart and kidney. Low levels in brain. Not expressed or low levels in variant small cell lung carcinomas, 33% of hepatocellular carcinomas and neuroblastomas.2 Publications

    Gene expression databases

    ArrayExpressiQ9BUP3.
    BgeeiQ9BUP3.
    CleanExiHS_HTATIP2.
    GenevestigatoriQ9BUP3.

    Organism-specific databases

    HPAiHPA006417.
    HPA024321.

    Interactioni

    Subunit structurei

    Monomer. Binds nuclear transport receptors XPO4, IPO5/RANBP5, IPO7, IPO9 and KPNB1 as well as GCN1L1/GCN1 and LRPPRC probably through their HEAT repeats. Binds NCOA5/CIA. Isoform 2 binds the proteasome subunit PSMD4/s5a through its N-terminus. Binds the activation domain of HIV-1 Tat.

    Protein-protein interaction databases

    BioGridi115804. 3 interactions.
    MINTiMINT-5003508.
    STRINGi9606.ENSP00000392985.

    Structurei

    Secondary structure

    1
    242
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Helixi6 – 1611
    Beta strandi20 – 245
    Helixi29 – 4113
    Beta strandi45 – 539
    Helixi60 – 645
    Beta strandi66 – 694
    Helixi72 – 8211
    Beta strandi86 – 905
    Helixi96 – 10813
    Helixi110 – 12112
    Beta strandi126 – 1305
    Helixi142 – 15514
    Beta strandi160 – 1667
    Beta strandi169 – 1713
    Helixi175 – 1773
    Helixi179 – 18810
    Helixi195 – 1984
    Beta strandi200 – 2023
    Helixi203 – 21412
    Beta strandi220 – 2267
    Helixi227 – 2337

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    2BKAX-ray1.70A1-242[»]
    ProteinModelPortaliQ9BUP3.
    SMRiQ9BUP3. Positions 5-235.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiQ9BUP3.

    Family & Domainsi

    Domaini

    Unique C-terminus confers high proteasome-dependent instability to isoform 2.1 Publication

    Phylogenomic databases

    eggNOGiCOG0702.
    HOVERGENiHBG052833.
    InParanoidiQ9BUP3.
    KOiK17290.
    OMAiHSVPVVT.
    OrthoDBiEOG7GJ6GJ.
    PhylomeDBiQ9BUP3.
    TreeFamiTF312849.

    Family and domain databases

    Gene3Di3.40.50.720. 1 hit.
    InterProiIPR016040. NAD(P)-bd_dom.
    [Graphical view]

    Sequences (3)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 3 isoformsi produced by alternative splicing. Align

    Isoform 11 Publication (identifier: Q9BUP3-1) [UniParc]FASTAAdd to Basket

    Also known as: CC31 Publication

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MAETEALSKL REDFRMQNKS VFILGASGET GRVLLKEILE QGLFSKVTLI    50
    GRRKLTFDEE AYKNVNQEVV DFEKLDDYAS AFQGHDVGFC CLGTTRGKAG 100
    AEGFVRVDRD YVLKSAELAK AGGCKHFNLL SSKGADKSSN FLYLQVKGEV 150
    EAKVEELKFD RYSVFRPGVL LCDRQESRPG EWLVRKFFGS LPDSWASGHS 200
    VPVVTVVRAM LNNVVRPRDK QMELLENKAI HDLGKAHGSL KP 242
    Length:242
    Mass (Da):27,049
    Last modified:January 11, 2011 - v2
    Checksum:i6A26E4A095243678
    GO
    Isoform 21 PublicationCurated (identifier: Q9BUP3-2) [UniParc]FASTAAdd to Basket

    Also known as: TC31 Publication

    The sequence of this isoform differs from the canonical sequence as follows:
         102-133: EGFVRVDRDYVLKSAELAKAGGCKHFNLLSSK → VRKAYALFPFCWPVISRILFLLTLFLCACCNA
         134-242: Missing.

    Note: Mutagenesis of Leu-154 and Leu-157 or Cys-158, Cys-160 and Cys-161 abolishes antiapoptotic effect.

    Show »
    Length:133
    Mass (Da):14,914
    Checksum:iD5C06E44FAE16E82
    GO
    Isoform 3 (identifier: Q9BUP3-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-1: M → MAGPAALSAAAAAALAAALLLLRREDPGPGAGPSM

    Show »
    Length:276
    Mass (Da):30,131
    Checksum:i655FB91EC4F33B34
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti87 – 871V → F in CAG33102. 1 PublicationCurated
    Sequence conflicti170 – 1701L → P in BAD96730. 1 PublicationCurated
    Sequence conflicti182 – 1821W → R in AAC39694. (PubMed:9482853)Curated
    Sequence conflicti187 – 1871F → L in AAB84360. (PubMed:9174052)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti106 – 1061R → S in a hepatocellular carcinoma sample. 1 Publication
    VAR_023713
    Natural varianti108 – 1081D → Y in a hepatocellular carcinoma sample. 1 Publication
    VAR_023714
    Natural varianti116 – 1161A → T in a hepatocellular carcinoma sample. 1 Publication
    VAR_023715
    Natural varianti134 – 1341G → V in a hepatocellular carcinoma sample; reduces protein stability. 1 Publication
    VAR_023716
    Natural varianti144 – 1441L → I in a hepatocellular carcinoma sample. 1 Publication
    VAR_023717
    Natural varianti197 – 1971S → R Highly associated with hepatocellular carcinoma (HCC) progression. 4 Publications
    Corresponds to variant rs3824886 [ dbSNP | Ensembl ].
    VAR_023718

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 11M → MAGPAALSAAAAAALAAALL LLRREDPGPGAGPSM in isoform 3. 1 PublicationVSP_038339
    Alternative sequencei102 – 13332EGFVR…LLSSK → VRKAYALFPFCWPVISRILF LLTLFLCACCNA in isoform 2. 2 PublicationsVSP_051864Add
    BLAST
    Alternative sequencei134 – 242109Missing in isoform 2. 2 PublicationsVSP_051865Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U69161 mRNA. Translation: AAB84360.1.
    AF039103 mRNA. Translation: AAC39694.1.
    AF092095 mRNA. Translation: AAC78331.1.
    AK292092 mRNA. Translation: BAF84781.1.
    CR456821 mRNA. Translation: CAG33102.1.
    AK223010 mRNA. Translation: BAD96730.1.
    AK222969 mRNA. Translation: BAD96689.1.
    AC025972 Genomic DNA. No translation available.
    CH471064 Genomic DNA. Translation: EAW68338.1.
    CH471064 Genomic DNA. Translation: EAW68339.1.
    BC002439 mRNA. Translation: AAH02439.2.
    BC015358 mRNA. Translation: AAH15358.1.
    CCDSiCCDS44553.1. [Q9BUP3-3]
    CCDS53613.1. [Q9BUP3-2]
    CCDS7852.1. [Q9BUP3-1]
    RefSeqiNP_001091990.1. NM_001098520.1. [Q9BUP3-3]
    NP_001091991.1. NM_001098521.1. [Q9BUP3-1]
    NP_001091992.1. NM_001098522.1. [Q9BUP3-1]
    NP_001091993.1. NM_001098523.1. [Q9BUP3-2]
    NP_006401.3. NM_006410.4. [Q9BUP3-1]
    UniGeneiHs.90753.

    Genome annotation databases

    EnsembliENST00000419348; ENSP00000392985; ENSG00000109854. [Q9BUP3-3]
    ENST00000421577; ENSP00000397752; ENSG00000109854. [Q9BUP3-1]
    ENST00000443524; ENSP00000387876; ENSG00000109854. [Q9BUP3-1]
    ENST00000451739; ENSP00000394259; ENSG00000109854. [Q9BUP3-1]
    ENST00000530266; ENSP00000436548; ENSG00000109854. [Q9BUP3-2]
    ENST00000532081; ENSP00000432107; ENSG00000109854. [Q9BUP3-2]
    ENST00000532505; ENSP00000432338; ENSG00000109854. [Q9BUP3-2]
    GeneIDi10553.
    KEGGihsa:10553.
    UCSCiuc001mpx.2. human. [Q9BUP3-3]
    uc001mpy.4. human. [Q9BUP3-2]
    uc001mpz.2. human. [Q9BUP3-1]

    Polymorphism databases

    DMDMi317373366.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Web resourcesi

    Atlas of Genetics and Cytogenetics in Oncology and Haematology

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U69161 mRNA. Translation: AAB84360.1 .
    AF039103 mRNA. Translation: AAC39694.1 .
    AF092095 mRNA. Translation: AAC78331.1 .
    AK292092 mRNA. Translation: BAF84781.1 .
    CR456821 mRNA. Translation: CAG33102.1 .
    AK223010 mRNA. Translation: BAD96730.1 .
    AK222969 mRNA. Translation: BAD96689.1 .
    AC025972 Genomic DNA. No translation available.
    CH471064 Genomic DNA. Translation: EAW68338.1 .
    CH471064 Genomic DNA. Translation: EAW68339.1 .
    BC002439 mRNA. Translation: AAH02439.2 .
    BC015358 mRNA. Translation: AAH15358.1 .
    CCDSi CCDS44553.1. [Q9BUP3-3 ]
    CCDS53613.1. [Q9BUP3-2 ]
    CCDS7852.1. [Q9BUP3-1 ]
    RefSeqi NP_001091990.1. NM_001098520.1. [Q9BUP3-3 ]
    NP_001091991.1. NM_001098521.1. [Q9BUP3-1 ]
    NP_001091992.1. NM_001098522.1. [Q9BUP3-1 ]
    NP_001091993.1. NM_001098523.1. [Q9BUP3-2 ]
    NP_006401.3. NM_006410.4. [Q9BUP3-1 ]
    UniGenei Hs.90753.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    2BKA X-ray 1.70 A 1-242 [» ]
    ProteinModelPortali Q9BUP3.
    SMRi Q9BUP3. Positions 5-235.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 115804. 3 interactions.
    MINTi MINT-5003508.
    STRINGi 9606.ENSP00000392985.

    PTM databases

    PhosphoSitei Q9BUP3.

    Polymorphism databases

    DMDMi 317373366.

    Proteomic databases

    MaxQBi Q9BUP3.
    PaxDbi Q9BUP3.
    PRIDEi Q9BUP3.

    Protocols and materials databases

    DNASUi 10553.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000419348 ; ENSP00000392985 ; ENSG00000109854 . [Q9BUP3-3 ]
    ENST00000421577 ; ENSP00000397752 ; ENSG00000109854 . [Q9BUP3-1 ]
    ENST00000443524 ; ENSP00000387876 ; ENSG00000109854 . [Q9BUP3-1 ]
    ENST00000451739 ; ENSP00000394259 ; ENSG00000109854 . [Q9BUP3-1 ]
    ENST00000530266 ; ENSP00000436548 ; ENSG00000109854 . [Q9BUP3-2 ]
    ENST00000532081 ; ENSP00000432107 ; ENSG00000109854 . [Q9BUP3-2 ]
    ENST00000532505 ; ENSP00000432338 ; ENSG00000109854 . [Q9BUP3-2 ]
    GeneIDi 10553.
    KEGGi hsa:10553.
    UCSCi uc001mpx.2. human. [Q9BUP3-3 ]
    uc001mpy.4. human. [Q9BUP3-2 ]
    uc001mpz.2. human. [Q9BUP3-1 ]

    Organism-specific databases

    CTDi 10553.
    GeneCardsi GC11P020341.
    HGNCi HGNC:16637. HTATIP2.
    HPAi HPA006417.
    HPA024321.
    MIMi 605628. gene.
    neXtProti NX_Q9BUP3.
    PharmGKBi PA29539.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG0702.
    HOVERGENi HBG052833.
    InParanoidi Q9BUP3.
    KOi K17290.
    OMAi HSVPVVT.
    OrthoDBi EOG7GJ6GJ.
    PhylomeDBi Q9BUP3.
    TreeFami TF312849.

    Miscellaneous databases

    EvolutionaryTracei Q9BUP3.
    GeneWikii HTATIP2.
    GenomeRNAii 10553.
    NextBioi 40029.
    PROi Q9BUP3.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q9BUP3.
    Bgeei Q9BUP3.
    CleanExi HS_HTATIP2.
    Genevestigatori Q9BUP3.

    Family and domain databases

    Gene3Di 3.40.50.720. 1 hit.
    InterProi IPR016040. NAD(P)-bd_dom.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "A link between metastasis and resistance to apoptosis of variant small cell lung carcinoma."
      Shtivelman E.
      Oncogene 14:2167-2173(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION, TISSUE SPECIFICITY, VARIANT ARG-197.
      Tissue: Lung cancer1 Publication.
    2. "A cofactor, TIP30, specifically enhances HIV-1 Tat-activated transcription."
      Xiao H., Tao Y., Greenblatt J., Roeder R.G.
      Proc. Natl. Acad. Sci. U.S.A. 95:2146-2151(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), INTERACTION WITH HIV-1 TAT.
      Tissue: Pancreatic islet.
    3. "Alternatively spliced products CC3 and TC3 have opposing effects on apoptosis."
      Whitman S., Wang X., Shalaby R., Shtivelman E.
      Mol. Cell. Biol. 20:583-593(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), FUNCTION, INTERACTION WITH PSMD4.
      Tissue: PlacentaImported.
    4. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Synovium.
    5. "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
      Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.
      Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    6. Suzuki Y., Sugano S., Totoki Y., Toyoda A., Takeda T., Sakaki Y., Tanaka A., Yokoyama S.
      Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Small intestineImported.
    7. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    8. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    9. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 3), VARIANT ARG-197.
      Tissue: CervixImported and Skin.
    10. "TIP30 has an intrinsic kinase activity required for up-regulation of a subset of apoptotic genes."
      Xiao H., Palhan V., Yang Y., Roeder R.G.
      EMBO J. 19:956-963(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: MUTAGENESIS OF 28-GLY--GLY-31.
    11. "Metastasis suppressor CC3 inhibits angiogenic properties of tumor cells in vitro."
      NicAmhlaoibh R., Shtivelman E.
      Oncogene 20:270-275(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.
    12. "TIP30 deficiency increases susceptibility to tumorigenesis."
      Ito M., Jiang C., Krumm K., Zhang X., Pecha J., Zhao J., Guo Y., Roeder R.G., Xiao H.
      Cancer Res. 63:8763-8767(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: TISSUE SPECIFICITY, VARIANTS SER-106; TYR-108; THR-116; VAL-134 AND ILE-144, MUTAGENESIS OF ARG-106, CHARACTERIZATION OF VARIANT VAL-134.
    13. "TIP30 interacts with an estrogen receptor alpha-interacting coactivator CIA and regulates c-myc transcription."
      Jiang C., Ito M., Piening V., Bruck K., Roeder R.G., Xiao H.
      J. Biol. Chem. 279:27781-27789(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH NCOA5.
    14. "Inhibition of nuclear import by the proapoptotic protein CC3."
      King F.W., Shtivelman E.
      Mol. Cell. Biol. 24:7091-7101(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, SUBCELLULAR LOCATION, INTERACTION WITH XPO4; IPO5; IPO7; IPO9; KPNB1; GCN1L1 AND LRPPRC.
    15. Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS], CLEAVAGE OF INITIATOR METHIONINE [LARGE SCALE ANALYSIS].
    16. "Crystal structure of CC3 (TIP30): implications for its role as a tumor suppressor."
      El Omari K., Bird L.E., Nichols C.E., Ren J., Stammers D.K.
      J. Biol. Chem. 280:18229-18236(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (1.7 ANGSTROMS).
    17. Cited for: VARIANT [LARGE SCALE ANALYSIS] ARG-197, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    18. "Large-scale quantification of single amino-acid variations by a variation-associated database search strategy."
      Song C., Wang F., Cheng K., Wei X., Bian Y., Wang K., Tan Y., Wang H., Ye M., Zou H.
      J. Proteome Res. 13:241-248(2014) [PubMed] [Europe PMC] [Abstract]
      Cited for: VARIANT ARG-197.

    Entry informationi

    Entry nameiHTAI2_HUMAN
    AccessioniPrimary (citable) accession number: Q9BUP3
    Secondary accession number(s): A8K7S7
    , D3DQY8, O15383, O60520, O95345, Q53GC1, Q53GG2, Q6IBI3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 25, 2005
    Last sequence update: January 11, 2011
    Last modified: October 1, 2014
    This is version 112 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. Human chromosome 11
      Human chromosome 11: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references

    External Data

    Dasty 3