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Q9BUP3

- HTAI2_HUMAN

UniProt

Q9BUP3 - HTAI2_HUMAN

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Protein

Oxidoreductase HTATIP2

Gene

HTATIP2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Oxidoreductase required for tumor suppression. NAPDH-bound form inhibits nuclear import by competing with nuclear import substrates for binding to a subset of nuclear transport receptors. May act as a redox sensor linked to transcription through regulation of nuclear import. Isoform 1 is a metastasis suppressor with proapoptotic as well as antiangiogenic properties. Isoform 2 has an antiapoptotic effect.4 Publications

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei131 – 1311Substrate1 Publication
Active sitei143 – 1431Proton acceptor1 Publication
Active sitei147 – 14711 Publication

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi19 – 5234NADP1 PublicationAdd
BLAST

GO - Molecular functioni

  1. oxidoreductase activity Source: UniProtKB-KW
  2. transcription coactivator activity Source: ProtInc

GO - Biological processi

  1. angiogenesis Source: UniProtKB-KW
  2. apoptotic process Source: UniProtKB-KW
  3. cell differentiation Source: UniProtKB-KW
  4. negative regulation of apoptotic process Source: UniProtKB
  5. nuclear import Source: UniProtKB
  6. regulation of angiogenesis Source: UniProtKB
  7. regulation of transcription from RNA polymerase II promoter Source: ProtInc
  8. viral process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein, Oxidoreductase

Keywords - Biological processi

Angiogenesis, Apoptosis, Differentiation, Host-virus interaction

Keywords - Ligandi

NADP

Names & Taxonomyi

Protein namesi
Recommended name:
Oxidoreductase HTATIP2 (EC:1.1.1.-)
Alternative name(s):
30 kDa HIV-1 TAT-interacting protein
HIV-1 TAT-interactive protein 2
Gene namesi
Name:HTATIP2Imported
Synonyms:CC3Imported, TIP301 Publication
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 11

Organism-specific databases

HGNCiHGNC:16637. HTATIP2.

Subcellular locationi

Cytoplasm 1 Publication. Nucleus envelope 1 Publication

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB
  2. membrane Source: UniProtKB
  3. nuclear envelope Source: UniProtKB
  4. nucleus Source: ProtInc
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi28 – 314GETG → VETA: Loss of proapoptotic and metastatis-inhibiting effect. 1 Publication
Mutagenesisi106 – 1061R → H: Loss of association with nucleus. 1 Publication

Keywords - Diseasei

Tumor suppressor

Organism-specific databases

PharmGKBiPA29539.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed1 Publication
Chaini2 – 242241Oxidoreductase HTATIP2PRO_0000072544Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylalanine1 Publication

Keywords - PTMi

Acetylation

Proteomic databases

MaxQBiQ9BUP3.
PaxDbiQ9BUP3.
PRIDEiQ9BUP3.

PTM databases

PhosphoSiteiQ9BUP3.

Expressioni

Tissue specificityi

Ubiquitous. Highest level in liver. High levels in lung, skeletal muscle, pancreas and placenta. Moderate levels in heart and kidney. Low levels in brain. Not expressed or low levels in variant small cell lung carcinomas, 33% of hepatocellular carcinomas and neuroblastomas.2 Publications

Gene expression databases

BgeeiQ9BUP3.
CleanExiHS_HTATIP2.
ExpressionAtlasiQ9BUP3. baseline and differential.
GenevestigatoriQ9BUP3.

Organism-specific databases

HPAiHPA006417.
HPA024321.

Interactioni

Subunit structurei

Monomer. Binds nuclear transport receptors XPO4, IPO5/RANBP5, IPO7, IPO9 and KPNB1 as well as GCN1L1/GCN1 and LRPPRC probably through their HEAT repeats. Binds NCOA5/CIA. Isoform 2 binds the proteasome subunit PSMD4/s5a through its N-terminus. Binds the activation domain of HIV-1 Tat.

Protein-protein interaction databases

BioGridi115804. 3 interactions.
MINTiMINT-5003508.
STRINGi9606.ENSP00000392985.

Structurei

Secondary structure

1
242
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi6 – 1611Combined sources
Beta strandi20 – 245Combined sources
Helixi29 – 4113Combined sources
Beta strandi45 – 539Combined sources
Helixi60 – 645Combined sources
Beta strandi66 – 694Combined sources
Helixi72 – 8211Combined sources
Beta strandi86 – 905Combined sources
Helixi96 – 10813Combined sources
Helixi110 – 12112Combined sources
Beta strandi126 – 1305Combined sources
Helixi142 – 15514Combined sources
Beta strandi160 – 1667Combined sources
Beta strandi169 – 1713Combined sources
Helixi175 – 1773Combined sources
Helixi179 – 18810Combined sources
Helixi195 – 1984Combined sources
Beta strandi200 – 2023Combined sources
Helixi203 – 21412Combined sources
Beta strandi220 – 2267Combined sources
Helixi227 – 2337Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2BKAX-ray1.70A1-242[»]
ProteinModelPortaliQ9BUP3.
SMRiQ9BUP3. Positions 5-235.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9BUP3.

Family & Domainsi

Domaini

Unique C-terminus confers high proteasome-dependent instability to isoform 2.1 Publication

Phylogenomic databases

eggNOGiCOG0702.
GeneTreeiENSGT00390000008184.
HOVERGENiHBG052833.
InParanoidiQ9BUP3.
KOiK17290.
OMAiHSVPVVT.
OrthoDBiEOG7GJ6GJ.
PhylomeDBiQ9BUP3.
TreeFamiTF312849.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
InterProiIPR016040. NAD(P)-bd_dom.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsi produced by alternative splicing. Align

Isoform 11 Publication (identifier: Q9BUP3-1) [UniParc]FASTAAdd to Basket

Also known as: CC31 Publication

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAETEALSKL REDFRMQNKS VFILGASGET GRVLLKEILE QGLFSKVTLI
60 70 80 90 100
GRRKLTFDEE AYKNVNQEVV DFEKLDDYAS AFQGHDVGFC CLGTTRGKAG
110 120 130 140 150
AEGFVRVDRD YVLKSAELAK AGGCKHFNLL SSKGADKSSN FLYLQVKGEV
160 170 180 190 200
EAKVEELKFD RYSVFRPGVL LCDRQESRPG EWLVRKFFGS LPDSWASGHS
210 220 230 240
VPVVTVVRAM LNNVVRPRDK QMELLENKAI HDLGKAHGSL KP
Length:242
Mass (Da):27,049
Last modified:January 11, 2011 - v2
Checksum:i6A26E4A095243678
GO
Isoform 21 PublicationCurated (identifier: Q9BUP3-2) [UniParc]FASTAAdd to Basket

Also known as: TC31 Publication

The sequence of this isoform differs from the canonical sequence as follows:
     102-133: EGFVRVDRDYVLKSAELAKAGGCKHFNLLSSK → VRKAYALFPFCWPVISRILFLLTLFLCACCNA
     134-242: Missing.

Note: Mutagenesis of Leu-154 and Leu-157 or Cys-158, Cys-160 and Cys-161 abolishes antiapoptotic effect.

Show »
Length:133
Mass (Da):14,914
Checksum:iD5C06E44FAE16E82
GO
Isoform 3 (identifier: Q9BUP3-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MAGPAALSAAAAAALAAALLLLRREDPGPGAGPSM

Show »
Length:276
Mass (Da):30,131
Checksum:i655FB91EC4F33B34
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti87 – 871V → F in CAG33102. 1 PublicationCurated
Sequence conflicti170 – 1701L → P in BAD96730. 1 PublicationCurated
Sequence conflicti182 – 1821W → R in AAC39694. (PubMed:9482853)Curated
Sequence conflicti187 – 1871F → L in AAB84360. (PubMed:9174052)Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti106 – 1061R → S in a hepatocellular carcinoma sample. 1 Publication
VAR_023713
Natural varianti108 – 1081D → Y in a hepatocellular carcinoma sample. 1 Publication
VAR_023714
Natural varianti116 – 1161A → T in a hepatocellular carcinoma sample. 1 Publication
VAR_023715
Natural varianti134 – 1341G → V in a hepatocellular carcinoma sample; reduces protein stability. 1 Publication
VAR_023716
Natural varianti144 – 1441L → I in a hepatocellular carcinoma sample. 1 Publication
VAR_023717
Natural varianti197 – 1971S → R Highly associated with hepatocellular carcinoma (HCC) progression. 4 Publications
Corresponds to variant rs3824886 [ dbSNP | Ensembl ].
VAR_023718

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 11M → MAGPAALSAAAAAALAAALL LLRREDPGPGAGPSM in isoform 3. 1 PublicationVSP_038339
Alternative sequencei102 – 13332EGFVR…LLSSK → VRKAYALFPFCWPVISRILF LLTLFLCACCNA in isoform 2. 2 PublicationsVSP_051864Add
BLAST
Alternative sequencei134 – 242109Missing in isoform 2. 2 PublicationsVSP_051865Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U69161 mRNA. Translation: AAB84360.1.
AF039103 mRNA. Translation: AAC39694.1.
AF092095 mRNA. Translation: AAC78331.1.
AK292092 mRNA. Translation: BAF84781.1.
CR456821 mRNA. Translation: CAG33102.1.
AK223010 mRNA. Translation: BAD96730.1.
AK222969 mRNA. Translation: BAD96689.1.
AC025972 Genomic DNA. No translation available.
CH471064 Genomic DNA. Translation: EAW68338.1.
CH471064 Genomic DNA. Translation: EAW68339.1.
BC002439 mRNA. Translation: AAH02439.2.
BC015358 mRNA. Translation: AAH15358.1.
CCDSiCCDS44553.1. [Q9BUP3-3]
CCDS53613.1. [Q9BUP3-2]
CCDS7852.1. [Q9BUP3-1]
RefSeqiNP_001091990.1. NM_001098520.1. [Q9BUP3-3]
NP_001091991.1. NM_001098521.1. [Q9BUP3-1]
NP_001091992.1. NM_001098522.1. [Q9BUP3-1]
NP_001091993.1. NM_001098523.1. [Q9BUP3-2]
NP_006401.3. NM_006410.4. [Q9BUP3-1]
UniGeneiHs.90753.

Genome annotation databases

EnsembliENST00000419348; ENSP00000392985; ENSG00000109854. [Q9BUP3-3]
ENST00000421577; ENSP00000397752; ENSG00000109854. [Q9BUP3-1]
ENST00000443524; ENSP00000387876; ENSG00000109854. [Q9BUP3-1]
ENST00000451739; ENSP00000394259; ENSG00000109854. [Q9BUP3-1]
ENST00000530266; ENSP00000436548; ENSG00000109854. [Q9BUP3-2]
ENST00000532081; ENSP00000432107; ENSG00000109854. [Q9BUP3-2]
ENST00000532505; ENSP00000432338; ENSG00000109854. [Q9BUP3-2]
GeneIDi10553.
KEGGihsa:10553.
UCSCiuc001mpx.2. human. [Q9BUP3-3]
uc001mpy.4. human. [Q9BUP3-2]
uc001mpz.2. human. [Q9BUP3-1]

Polymorphism databases

DMDMi317373366.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U69161 mRNA. Translation: AAB84360.1 .
AF039103 mRNA. Translation: AAC39694.1 .
AF092095 mRNA. Translation: AAC78331.1 .
AK292092 mRNA. Translation: BAF84781.1 .
CR456821 mRNA. Translation: CAG33102.1 .
AK223010 mRNA. Translation: BAD96730.1 .
AK222969 mRNA. Translation: BAD96689.1 .
AC025972 Genomic DNA. No translation available.
CH471064 Genomic DNA. Translation: EAW68338.1 .
CH471064 Genomic DNA. Translation: EAW68339.1 .
BC002439 mRNA. Translation: AAH02439.2 .
BC015358 mRNA. Translation: AAH15358.1 .
CCDSi CCDS44553.1. [Q9BUP3-3 ]
CCDS53613.1. [Q9BUP3-2 ]
CCDS7852.1. [Q9BUP3-1 ]
RefSeqi NP_001091990.1. NM_001098520.1. [Q9BUP3-3 ]
NP_001091991.1. NM_001098521.1. [Q9BUP3-1 ]
NP_001091992.1. NM_001098522.1. [Q9BUP3-1 ]
NP_001091993.1. NM_001098523.1. [Q9BUP3-2 ]
NP_006401.3. NM_006410.4. [Q9BUP3-1 ]
UniGenei Hs.90753.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
2BKA X-ray 1.70 A 1-242 [» ]
ProteinModelPortali Q9BUP3.
SMRi Q9BUP3. Positions 5-235.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 115804. 3 interactions.
MINTi MINT-5003508.
STRINGi 9606.ENSP00000392985.

PTM databases

PhosphoSitei Q9BUP3.

Polymorphism databases

DMDMi 317373366.

Proteomic databases

MaxQBi Q9BUP3.
PaxDbi Q9BUP3.
PRIDEi Q9BUP3.

Protocols and materials databases

DNASUi 10553.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000419348 ; ENSP00000392985 ; ENSG00000109854 . [Q9BUP3-3 ]
ENST00000421577 ; ENSP00000397752 ; ENSG00000109854 . [Q9BUP3-1 ]
ENST00000443524 ; ENSP00000387876 ; ENSG00000109854 . [Q9BUP3-1 ]
ENST00000451739 ; ENSP00000394259 ; ENSG00000109854 . [Q9BUP3-1 ]
ENST00000530266 ; ENSP00000436548 ; ENSG00000109854 . [Q9BUP3-2 ]
ENST00000532081 ; ENSP00000432107 ; ENSG00000109854 . [Q9BUP3-2 ]
ENST00000532505 ; ENSP00000432338 ; ENSG00000109854 . [Q9BUP3-2 ]
GeneIDi 10553.
KEGGi hsa:10553.
UCSCi uc001mpx.2. human. [Q9BUP3-3 ]
uc001mpy.4. human. [Q9BUP3-2 ]
uc001mpz.2. human. [Q9BUP3-1 ]

Organism-specific databases

CTDi 10553.
GeneCardsi GC11P020385.
HGNCi HGNC:16637. HTATIP2.
HPAi HPA006417.
HPA024321.
MIMi 605628. gene.
neXtProti NX_Q9BUP3.
PharmGKBi PA29539.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG0702.
GeneTreei ENSGT00390000008184.
HOVERGENi HBG052833.
InParanoidi Q9BUP3.
KOi K17290.
OMAi HSVPVVT.
OrthoDBi EOG7GJ6GJ.
PhylomeDBi Q9BUP3.
TreeFami TF312849.

Miscellaneous databases

EvolutionaryTracei Q9BUP3.
GeneWikii HTATIP2.
GenomeRNAii 10553.
NextBioi 40029.
PROi Q9BUP3.
SOURCEi Search...

Gene expression databases

Bgeei Q9BUP3.
CleanExi HS_HTATIP2.
ExpressionAtlasi Q9BUP3. baseline and differential.
Genevestigatori Q9BUP3.

Family and domain databases

Gene3Di 3.40.50.720. 1 hit.
InterProi IPR016040. NAD(P)-bd_dom.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "A link between metastasis and resistance to apoptosis of variant small cell lung carcinoma."
    Shtivelman E.
    Oncogene 14:2167-2173(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION, TISSUE SPECIFICITY, VARIANT ARG-197.
    Tissue: Lung cancer1 Publication.
  2. "A cofactor, TIP30, specifically enhances HIV-1 Tat-activated transcription."
    Xiao H., Tao Y., Greenblatt J., Roeder R.G.
    Proc. Natl. Acad. Sci. U.S.A. 95:2146-2151(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), INTERACTION WITH HIV-1 TAT.
    Tissue: Pancreatic islet.
  3. "Alternatively spliced products CC3 and TC3 have opposing effects on apoptosis."
    Whitman S., Wang X., Shalaby R., Shtivelman E.
    Mol. Cell. Biol. 20:583-593(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), FUNCTION, INTERACTION WITH PSMD4.
    Tissue: PlacentaImported.
  4. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Synovium.
  5. "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
    Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.
    Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
  6. Suzuki Y., Sugano S., Totoki Y., Toyoda A., Takeda T., Sakaki Y., Tanaka A., Yokoyama S.
    Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Small intestineImported.
  7. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  8. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  9. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 3), VARIANT ARG-197.
    Tissue: CervixImported and Skin.
  10. "TIP30 has an intrinsic kinase activity required for up-regulation of a subset of apoptotic genes."
    Xiao H., Palhan V., Yang Y., Roeder R.G.
    EMBO J. 19:956-963(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: MUTAGENESIS OF 28-GLY--GLY-31.
  11. "Metastasis suppressor CC3 inhibits angiogenic properties of tumor cells in vitro."
    NicAmhlaoibh R., Shtivelman E.
    Oncogene 20:270-275(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  12. "TIP30 deficiency increases susceptibility to tumorigenesis."
    Ito M., Jiang C., Krumm K., Zhang X., Pecha J., Zhao J., Guo Y., Roeder R.G., Xiao H.
    Cancer Res. 63:8763-8767(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY, VARIANTS SER-106; TYR-108; THR-116; VAL-134 AND ILE-144, MUTAGENESIS OF ARG-106, CHARACTERIZATION OF VARIANT VAL-134.
  13. "TIP30 interacts with an estrogen receptor alpha-interacting coactivator CIA and regulates c-myc transcription."
    Jiang C., Ito M., Piening V., Bruck K., Roeder R.G., Xiao H.
    J. Biol. Chem. 279:27781-27789(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH NCOA5.
  14. "Inhibition of nuclear import by the proapoptotic protein CC3."
    King F.W., Shtivelman E.
    Mol. Cell. Biol. 24:7091-7101(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBCELLULAR LOCATION, INTERACTION WITH XPO4; IPO5; IPO7; IPO9; KPNB1; GCN1L1 AND LRPPRC.
  15. Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS], CLEAVAGE OF INITIATOR METHIONINE [LARGE SCALE ANALYSIS].
  16. "Crystal structure of CC3 (TIP30): implications for its role as a tumor suppressor."
    El Omari K., Bird L.E., Nichols C.E., Ren J., Stammers D.K.
    J. Biol. Chem. 280:18229-18236(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (1.7 ANGSTROMS).
  17. Cited for: VARIANT [LARGE SCALE ANALYSIS] ARG-197, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  18. "Large-scale quantification of single amino-acid variations by a variation-associated database search strategy."
    Song C., Wang F., Cheng K., Wei X., Bian Y., Wang K., Tan Y., Wang H., Ye M., Zou H.
    J. Proteome Res. 13:241-248(2014) [PubMed] [Europe PMC] [Abstract]
    Cited for: VARIANT ARG-197.

Entry informationi

Entry nameiHTAI2_HUMAN
AccessioniPrimary (citable) accession number: Q9BUP3
Secondary accession number(s): A8K7S7
, D3DQY8, O15383, O60520, O95345, Q53GC1, Q53GG2, Q6IBI3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 25, 2005
Last sequence update: January 11, 2011
Last modified: November 26, 2014
This is version 114 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references

External Data

Dasty 3