Reviewed,
UniProtKB/Swiss-Prot Q9BUL9 (RPP25_HUMAN)
Last modified
November 24, 2009.
Version 55.
History...
Clusters with 100%,
90%,
50% identity |
Documents (2) |
Third-party data |
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Names and origin
| Protein names | Recommended name: Ribonuclease P protein subunit p25 Short name=RNase P protein subunit p25 EC=3.1.26.5 | ||
| Gene names |
| ||
| Organism | Homo sapiens (Human) [Complete proteome] | ||
| Taxonomic identifier | 9606 [NCBI] | ||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Protein attributes
| Sequence length | 199 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is not processed. |
| Protein existence | Evidence at protein level. |
General annotation (Comments)
| Function | Component of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends. Also a component of RNase MRP. This subunit binds to RNA. |
| Catalytic activity | Endonucleolytic cleavage of RNA, removing 5'-extranucleotides from tRNA precursor. |
| Subunit structure | Component of nuclear RNase P and RNase MRP ribonucleoproteins. RNase P consists of a RNA moiety and at least 8 protein subunits; POP1, RPP14, RPP20/POP7, RPP25, RPP29/POP4, RPP30, RPP38 and RPP40. Interacts with the P3 domain of RNase MRP complex. RNase MRP consists of a RNA moiety and at least 9 protein subunits; POP1, RPP14, RPP20/POP7, RPP25, RPP29/POP4, RPP30, RPP38, RPP40, POP5 and RPP21. Ref.4 |
| Subcellular location | |
| Sequence similarities | Belongs to the histone-like Alba family. |
Ontologies
| Keywords | |
|---|---|
| Biological process | tRNA processing |
| Cellular component | Nucleus |
| Ligand | RNA-binding |
| Molecular function | Hydrolase |
| PTM | Phosphoprotein |
| Technical term | Complete proteome |
| Gene Ontology (GO) | |
| Biological process | tRNA processing Inferred from electronic annotation. Source: UniProtKB-KW |
| Cellular component | nucleus Inferred from electronic annotation. Source: UniProtKB-SubCell |
| Molecular function | RNA binding Inferred from electronic annotation. Source: UniProtKB-KW protein binding Ref.4Inferred from physical interaction. Source: IntAct ribonuclease P activityInferred from electronic annotation. Source: EC |
| Complete GO annotation... | |
Binary interactions
With | Entry | #Exp. | IntAct | Notes |
|---|---|---|---|---|
| POP1 | Q99575 | 1 | EBI-366570,EBI-366741 | |
| POP4 | O95707 | 1 | EBI-366570,EBI-366477 | |
| POP5 | Q969H6 | 1 | EBI-366570,EBI-366525 | |
| POP7 | O75817 | 1 | EBI-366570,EBI-366574 | |
| RPP14 | O95059 | 1 | EBI-366570,EBI-366542 |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 199 | 199 | Ribonuclease P protein subunit p25 | PRO_0000237582 | |||||
Amino acid modifications | |||||||||
| Modified residue | 162 | 1 | Phosphoserine Ref.5 | ||||||
| Modified residue | 172 | 1 | Phosphoserine Ref.6 | ||||||
Experimental info | |||||||||
| Sequence conflict | 73 | 1 | A → V in BAA91128. Ref.2 | ||||||
Sequences
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References
| « Hide 'large scale' references | |
| [1] | "Purification and characterization of Rpp25, an RNA-binding protein subunit of human ribonuclease P." Guerrier-Takada C., Eder P.S., Gopalan V., Altman S. RNA 8:290-295(2002) [PubMed: 12003489] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], RNA-BINDING, SUBCELLULAR LOCATION. |
| [2] | "Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. Sugano S.Nat. Genet. 36:40-45(2004) [PubMed: 14702039] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. |
| [3] | "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Brain and Skin. |
| [4] | "Mutual interactions between subunits of the human RNase MRP ribonucleoprotein complex." Welting T.J., van Venrooij W.J., Pruijn G.J. Nucleic Acids Res. 32:2138-2146(2004) [PubMed: 15096576] [Abstract] Cited for: INTERACTION WITH POP7; POP4 AND RMRP. |
| [5] | "Global proteomic profiling of phosphopeptides using electron transfer dissociation tandem mass spectrometry." Molina H., Horn D.M., Tang N., Mathivanan S., Pandey A. Proc. Natl. Acad. Sci. U.S.A. 104:2199-2204(2007) [PubMed: 17287340] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-162, MASS SPECTROMETRY. |
| [6] | "A quantitative atlas of mitotic phosphorylation." Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P. Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed: 18669648] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-172, MASS SPECTROMETRY. |
| [7] | Colinge J., Superti-Furga G., Bennett K.L. Submitted (OCT-2008) to UniProtKB Cited for: IDENTIFICATION [LARGE SCALE ANALYSIS], MASS SPECTROMETRY. |
Cross-references
Sequence databases | |
|---|---|
| AY034074 mRNA. Translation: AAK54443.1. AK000381 mRNA. Translation: BAA91128.1. BC002497 mRNA. Translation: AAH02497.1. BC007270 mRNA. Translation: AAH07270.1. | |
| IPI | IPI00306056. |
| RefSeq | NP_060263.2. |
| UniGene | Hs.8562 |
3D structure databases | |
| ModBase | Search... |
Protein-protein interaction databases | |
| IntAct | Q9BUL9. 5 interactions. |
| STRING | Q9BUL9. |
PTM databases | |
| PhosphoSite | Q9BUL9. |
Proteomic databases | |
| PeptideAtlas | Q9BUL9. |
| PRIDE | Q9BUL9. |
Genome annotation databases | |
| Ensembl | ENST00000322177; ENSP00000317691; ENSG00000178718; Homo sapiens. [Genome view] |
| GeneID | 54913. |
| KEGG | hsa:54913. |
| UCSC | uc002azj.1. human. |
Organism-specific databases | |
| CTD | 54913. |
| GeneCards | GC15M073034. |
| H-InvDB | HIX0012434. |
| HGNC | HGNC:30361. RPP25. |
| PharmGKB | PA134990737. |
| GenAtlas | Search... |
Phylogenomic databases | |
| HOGENOM | Q9BUL9. |
| HOVERGEN | Q9BUL9. |
| OMA | MENFRKV |
| OrthoDB | EOG92FW3N |
Enzyme and pathway databases | |
| BRENDA | 3.1.26.5. 247. |
Gene expression databases | |
| ArrayExpress | Q9BUL9. |
| Bgee | Q9BUL9. |
| CleanEx | HS_RPP25. |
| Genevestigator | Q9BUL9. |
| GermOnline | ENSG00000178718. Homo sapiens. |
Family and domain databases | |
| InterPro | IPR002775. Alba_bd. [Graphical view] |
| Pfam | PF01918. Alba. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Other Resources | |
| NextBio | 57966. |
Entry information
| Entry name | RPP25_HUMAN | ||||||||
| Accession | Primary (citable) accession number: Q9BUL9 Secondary accession number(s): Q9NX88 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HPI (Human Proteome Initiative) | ||||||||
| Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. | ||||||||
Relevant documents
| Human chromosome 15 Human chromosome 15: entries, gene names and cross-references to MIM |
| SIMILARITY comments Index of protein domains and families |

Clusters with


