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Protein

Ribonuclease P protein subunit p25

Gene

RPP25

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Component of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends. Also a component of RNase MRP. This subunit binds to RNA.

Catalytic activityi

Endonucleolytic cleavage of RNA, removing 5'-extranucleotides from tRNA precursor.

GO - Molecular functioni

GO - Biological processi

  • rRNA processing Source: Reactome
  • tRNA 5'-leader removal Source: FlyBase

Keywordsi

Molecular functionHydrolase, RNA-binding
Biological processtRNA processing

Enzyme and pathway databases

ReactomeiR-HSA-6784531 tRNA processing in the nucleus
R-HSA-6791226 Major pathway of rRNA processing in the nucleolus and cytosol

Names & Taxonomyi

Protein namesi
Recommended name:
Ribonuclease P protein subunit p25 (EC:3.1.26.5)
Short name:
RNase P protein subunit p25
Gene namesi
Name:RPP25
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 15

Organism-specific databases

EuPathDBiHostDB:ENSG00000178718.6
HGNCiHGNC:30361 RPP25
neXtProtiNX_Q9BUL9

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi54913
OpenTargetsiENSG00000178718
PharmGKBiPA134990737

Polymorphism and mutation databases

BioMutaiRPP25
DMDMi74733233

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002375821 – 199Ribonuclease P protein subunit p25Add BLAST199

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei172PhosphoserineCombined sources1
Modified residuei182PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ9BUL9
MaxQBiQ9BUL9
PaxDbiQ9BUL9
PeptideAtlasiQ9BUL9
PRIDEiQ9BUL9

PTM databases

iPTMnetiQ9BUL9
PhosphoSitePlusiQ9BUL9

Expressioni

Gene expression databases

BgeeiENSG00000178718
CleanExiHS_RPP25
GenevisibleiQ9BUL9 HS

Organism-specific databases

HPAiHPA046900

Interactioni

Subunit structurei

Component of nuclear RNase P and RNase MRP ribonucleoproteins. RNase P consists of an RNA moiety and at least 8 protein subunits; POP1, RPP14, RPP20/POP7, RPP25, RPP29/POP4, RPP30, RPP38 and RPP40. Interacts with the P3 domain of RNase MRP complex. RNase MRP consists of an RNA moiety and at least 9 protein subunits; POP1, RPP14, RPP20/POP7, RPP25, RPP29/POP4, RPP30, RPP38, RPP40, POP5 and RPP21.1 Publication

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi120255, 22 interactors
CORUMiQ9BUL9
IntActiQ9BUL9, 20 interactors
STRINGi9606.ENSP00000317691

Structurei

3D structure databases

ProteinModelPortaliQ9BUL9
SMRiQ9BUL9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the histone-like Alba family.Curated

Phylogenomic databases

eggNOGiKOG2567 Eukaryota
ENOG4111WGZ LUCA
GeneTreeiENSGT00390000002564
HOGENOMiHOG000231665
HOVERGENiHBG056729
InParanoidiQ9BUL9
KOiK14525
OMAiAVHMRVK
OrthoDBiEOG091G0OAF
PhylomeDBiQ9BUL9
TreeFamiTF325688

Family and domain databases

Gene3Di3.30.110.20, 1 hit
InterProiView protein in InterPro
IPR036882 Alba-like_dom_sf
IPR002775 DNA/RNA-bd_Alba-like
PfamiView protein in Pfam
PF01918 Alba, 1 hit
SUPFAMiSSF82704 SSF82704, 1 hit

Sequencei

Sequence statusi: Complete.

Q9BUL9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MENFRKVRSE EAPAGCGAEG GGPGSGPFAD LAPGAVHMRV KEGSKIRNLM
60 70 80 90 100
AFATASMAQP ATRAIVFSGC GRATTKTVTC AEILKRRLAG LHQVTRLRYR
110 120 130 140 150
SVREVWQSLP PGPTQGQTPG EPAASLSVLK NVPGLAILLS KDALDPRQPG
160 170 180 190
YQPPNPHPGP SSPPAAPASK RSLGEPAAGE GSAKRSQPEP GVADEDQTA
Length:199
Mass (Da):20,632
Last modified:June 1, 2001 - v1
Checksum:i9A4494F0297B2A81
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti73A → V in BAA91128 (PubMed:14702039).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY034074 mRNA Translation: AAK54443.1
AK000381 mRNA Translation: BAA91128.1
CH471136 Genomic DNA Translation: EAW99285.1
CH471136 Genomic DNA Translation: EAW99286.1
BC002497 mRNA Translation: AAH02497.1
BC007270 mRNA Translation: AAH07270.1
CCDSiCCDS10274.1
RefSeqiNP_060263.2, NM_017793.2
UniGeneiHs.8562

Genome annotation databases

EnsembliENST00000322177; ENSP00000317691; ENSG00000178718
GeneIDi54913
KEGGihsa:54913
UCSCiuc002azj.2 human

Similar proteinsi

Entry informationi

Entry nameiRPP25_HUMAN
AccessioniPrimary (citable) accession number: Q9BUL9
Secondary accession number(s): D3DW70, Q9NX88
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2006
Last sequence update: June 1, 2001
Last modified: March 28, 2018
This is version 118 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health