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Protein

Protein misato homolog 1

Gene

MSTO1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Involved in the regulation of mitochondrial distribution and morphology.1 Publication

GO - Molecular functioni

GO - Biological processi

  • mitochondrion distribution Source: UniProtKB
  • mitochondrion organization Source: UniProtKB
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Protein misato homolog 1
Gene namesi
Name:MSTO1
ORF Names:LST005, SLTP005
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:29678. MSTO1.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: LIFEdb
  • mitochondrial outer membrane Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion outer membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA142671313.

Polymorphism and mutation databases

BioMutaiMSTO1.
DMDMi74752357.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 570570Protein misato homolog 1PRO_0000304626Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei495 – 4951PhosphoserineCombined sources

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ9BUK6.
MaxQBiQ9BUK6.
PaxDbiQ9BUK6.
PeptideAtlasiQ9BUK6.
PRIDEiQ9BUK6.

PTM databases

iPTMnetiQ9BUK6.
PhosphoSiteiQ9BUK6.

Expressioni

Tissue specificityi

Present in all cell lines tested (at protein level). Widely expressed.1 Publication

Gene expression databases

BgeeiENSG00000125459.
CleanExiHS_MSTO1.
ExpressionAtlasiQ9BUK6. baseline and differential.
GenevisibleiQ9BUK6. HS.

Organism-specific databases

HPAiHPA005899.
HPA005914.

Interactioni

Protein-protein interaction databases

BioGridi120457. 19 interactions.
IntActiQ9BUK6. 8 interactions.
MINTiMINT-4717955.
STRINGi9606.ENSP00000245564.

Structurei

3D structure databases

ProteinModelPortaliQ9BUK6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the misato family.Curated

Phylogenomic databases

eggNOGiKOG2530. Eukaryota.
ENOG410XPM0. LUCA.
GeneTreeiENSGT00530000064067.
HOVERGENiHBG108151.
InParanoidiQ9BUK6.
OMAiQTTYTPR.
OrthoDBiEOG091G0FFX.
PhylomeDBiQ9BUK6.
TreeFamiTF323669.

Family and domain databases

Gene3Di3.40.50.1440. 2 hits.
InterProiIPR029209. DML1/Misato_tubulin.
IPR019605. Misato_II_tubulin-like.
IPR003008. Tubulin_FtsZ_GTPase.
[Graphical view]
PfamiPF10644. Misat_Tub_SegII. 1 hit.
PF14881. Tubulin_3. 1 hit.
[Graphical view]
SUPFAMiSSF52490. SSF52490. 2 hits.

Sequences (7)i

Sequence statusi: Complete.

This entry describes 7 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9BUK6-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAGGAREVLT LQLGHFAGFV GAHWWNQQDA ALGRATDSKE PPGELCPDVL
60 70 80 90 100
YRTGRTLHGQ ETYTPRLILM DLKGSLSSLK EEGGLYRDKQ LDAAIAWQGK
110 120 130 140 150
LTTHKEELYP KNPYLQDFLS AEGVLSSDGV WRVKSIPNGK GSSPLPTATT
160 170 180 190 200
PKPLIPTEAS IRVWSDFLRV HLHPRSICMI QKYNHDGEAG RLEAFGQGES
210 220 230 240 250
VLKEPKYQEE LEDRLHFYVE ECDYLQGFQI LCDLHDGFSG VGAKAAELLQ
260 270 280 290 300
DEYSGRGIIT WGLLPGPYHR GEAQRNIYRL LNTAFGLVHL TAHSSLVCPL
310 320 330 340 350
SLGGSLGLRP EPPVSFPYLH YDATLPFHCS AILATALDTV TVPYRLCSSP
360 370 380 390 400
VSMVHLADML SFCGKKVVTA GAIIPFPLAP GQSLPDSLMQ FGGATPWTPL
410 420 430 440 450
SACGEPSGTR CFAQSVVLRG IDRACHTSQL TPGTPPPSAL HACTTGEEIL
460 470 480 490 500
AQYLQQQQPG VMSSSHLLLT PCRVAPPYPH LFSSCSPPGM VLDGSPKGAA
510 520 530 540 550
VESIPVFGAL CSSSSLHQTL EALARDLTKL DLRRWASFMD AGVEHDDVAE
560 570
LLQELQSLAQ CYQGGDSLVD
Length:570
Mass (Da):61,835
Last modified:June 1, 2001 - v1
Checksum:iA139748AF2798619
GO
Isoform 2 (identifier: Q9BUK6-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     499-499: Missing.

Show »
Length:569
Mass (Da):61,764
Checksum:iBEF188A94366DA80
GO
Isoform 3 (identifier: Q9BUK6-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     489-500: Missing.

Note: No experimental confirmation available.
Show »
Length:558
Mass (Da):60,751
Checksum:i7608363DFE62A188
GO
Isoform 4 (identifier: Q9BUK6-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     98-99: QG → EC
     100-570: Missing.

Note: No experimental confirmation available.
Show »
Length:99
Mass (Da):10,886
Checksum:i3EF3D20EA7056658
GO
Isoform 5 (identifier: Q9BUK6-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-178: Missing.
     499-499: Missing.

Show »
Length:391
Mass (Da):42,151
Checksum:i9540473C3F1E7346
GO
Isoform 6 (identifier: Q9BUK6-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-388: Missing.

Show »
Length:182
Mass (Da):19,278
Checksum:i018C425E9BEB648F
GO
Isoform 7 (identifier: Q9BUK6-7) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     105-139: Missing.
     489-499: Missing.

Note: No experimental confirmation available.
Show »
Length:524
Mass (Da):56,903
Checksum:i9741EB34DB6A33B6
GO

Sequence cautioni

The sequence AAM12424 differs from that shown. Reason: Frameshift at position 419. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti389 – 3891M → V in BAA91651 (PubMed:14702039).Curated
Sequence conflicti482 – 4821F → S in AK092950 (PubMed:14702039).Curated
Sequence conflicti563 – 5631Q → P in CAI59784 (PubMed:17974005).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti324 – 3241T → I.
Corresponds to variant rs622288 [ dbSNP | Ensembl ].
VAR_035046

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 388388Missing in isoform 6. 1 PublicationVSP_028049Add
BLAST
Alternative sequencei1 – 178178Missing in isoform 5. 1 PublicationVSP_028050Add
BLAST
Alternative sequencei98 – 992QG → EC in isoform 4. 1 PublicationVSP_028051
Alternative sequencei100 – 570471Missing in isoform 4. 1 PublicationVSP_028052Add
BLAST
Alternative sequencei105 – 13935Missing in isoform 7. 1 PublicationVSP_028053Add
BLAST
Alternative sequencei489 – 50012Missing in isoform 3. 1 PublicationVSP_028054Add
BLAST
Alternative sequencei489 – 49911Missing in isoform 7. 1 PublicationVSP_028055Add
BLAST
Alternative sequencei499 – 4991Missing in isoform 2 and isoform 5. 2 PublicationsVSP_028056

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF111708 mRNA. Translation: AAM12424.1. Frameshift.
AY334564 mRNA. Translation: AAP94730.1.
AK001366 mRNA. Translation: BAA91651.1.
AK092950 mRNA. No translation available.
AK222863 mRNA. Translation: BAD96583.1.
BX537684 mRNA. Translation: CAD97810.1.
CR749791 mRNA. Translation: CAH18652.1.
CR936872 Transcribed RNA. Translation: CAI59784.1.
AL353807 Genomic DNA. Translation: CAI13215.1.
AL353807 Genomic DNA. Translation: CAI13216.1.
BC002535 mRNA. Translation: AAH02535.1.
AF272833 mRNA. Translation: AAF81794.1.
CCDSiCCDS1114.1. [Q9BUK6-1]
RefSeqiNP_001243461.1. NM_001256532.1. [Q9BUK6-2]
NP_001243462.1. NM_001256533.1. [Q9BUK6-3]
NP_060586.2. NM_018116.3. [Q9BUK6-1]
XP_011508010.1. XM_011509708.1. [Q9BUK6-5]
UniGeneiHs.656547.

Genome annotation databases

EnsembliENST00000245564; ENSP00000245564; ENSG00000125459. [Q9BUK6-1]
ENST00000368341; ENSP00000357325; ENSG00000125459. [Q9BUK6-7]
ENST00000490743; ENSP00000476353; ENSG00000125459. [Q9BUK6-4]
GeneIDi55154.
KEGGihsa:55154.
UCSCiuc001fky.5. human. [Q9BUK6-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF111708 mRNA. Translation: AAM12424.1. Frameshift.
AY334564 mRNA. Translation: AAP94730.1.
AK001366 mRNA. Translation: BAA91651.1.
AK092950 mRNA. No translation available.
AK222863 mRNA. Translation: BAD96583.1.
BX537684 mRNA. Translation: CAD97810.1.
CR749791 mRNA. Translation: CAH18652.1.
CR936872 Transcribed RNA. Translation: CAI59784.1.
AL353807 Genomic DNA. Translation: CAI13215.1.
AL353807 Genomic DNA. Translation: CAI13216.1.
BC002535 mRNA. Translation: AAH02535.1.
AF272833 mRNA. Translation: AAF81794.1.
CCDSiCCDS1114.1. [Q9BUK6-1]
RefSeqiNP_001243461.1. NM_001256532.1. [Q9BUK6-2]
NP_001243462.1. NM_001256533.1. [Q9BUK6-3]
NP_060586.2. NM_018116.3. [Q9BUK6-1]
XP_011508010.1. XM_011509708.1. [Q9BUK6-5]
UniGeneiHs.656547.

3D structure databases

ProteinModelPortaliQ9BUK6.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi120457. 19 interactions.
IntActiQ9BUK6. 8 interactions.
MINTiMINT-4717955.
STRINGi9606.ENSP00000245564.

PTM databases

iPTMnetiQ9BUK6.
PhosphoSiteiQ9BUK6.

Polymorphism and mutation databases

BioMutaiMSTO1.
DMDMi74752357.

Proteomic databases

EPDiQ9BUK6.
MaxQBiQ9BUK6.
PaxDbiQ9BUK6.
PeptideAtlasiQ9BUK6.
PRIDEiQ9BUK6.

Protocols and materials databases

DNASUi55154.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000245564; ENSP00000245564; ENSG00000125459. [Q9BUK6-1]
ENST00000368341; ENSP00000357325; ENSG00000125459. [Q9BUK6-7]
ENST00000490743; ENSP00000476353; ENSG00000125459. [Q9BUK6-4]
GeneIDi55154.
KEGGihsa:55154.
UCSCiuc001fky.5. human. [Q9BUK6-1]

Organism-specific databases

CTDi55154.
GeneCardsiMSTO1.
H-InvDBHIX0001133.
HGNCiHGNC:29678. MSTO1.
HPAiHPA005899.
HPA005914.
neXtProtiNX_Q9BUK6.
PharmGKBiPA142671313.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2530. Eukaryota.
ENOG410XPM0. LUCA.
GeneTreeiENSGT00530000064067.
HOVERGENiHBG108151.
InParanoidiQ9BUK6.
OMAiQTTYTPR.
OrthoDBiEOG091G0FFX.
PhylomeDBiQ9BUK6.
TreeFamiTF323669.

Miscellaneous databases

GeneWikiiMSTO1.
GenomeRNAii55154.
PROiQ9BUK6.

Gene expression databases

BgeeiENSG00000125459.
CleanExiHS_MSTO1.
ExpressionAtlasiQ9BUK6. baseline and differential.
GenevisibleiQ9BUK6. HS.

Family and domain databases

Gene3Di3.40.50.1440. 2 hits.
InterProiIPR029209. DML1/Misato_tubulin.
IPR019605. Misato_II_tubulin-like.
IPR003008. Tubulin_FtsZ_GTPase.
[Graphical view]
PfamiPF10644. Misat_Tub_SegII. 1 hit.
PF14881. Tubulin_3. 1 hit.
[Graphical view]
SUPFAMiSSF52490. SSF52490. 2 hits.
ProtoNetiSearch...

Entry informationi

Entry nameiMSTO1_HUMAN
AccessioniPrimary (citable) accession number: Q9BUK6
Secondary accession number(s): Q53GR8
, Q5CZ69, Q5T717, Q68CT6, Q7LBZ8, Q7Z3M7, Q7Z558, Q8TE05, Q9NQX2, Q9NVU4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 11, 2007
Last sequence update: June 1, 2001
Last modified: September 7, 2016
This is version 120 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.